<?xml version="1.0" encoding="UTF-8"?>
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<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSI3</accession>
    <name>B8DSI3_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName evidence="7">Glu-ADT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">gatA</name>
        <name evidence="9" type="ordered locus">BLA_0669</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219118.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0669"/>
    <dbReference type="EnsemblBacteria" id="ACL28962">
        <property type="protein sequence ID" value="ACL28962"/>
        <property type="gene ID" value="BLA_0669"/>
    </dbReference>
    <dbReference type="GeneID" id="66533802"/>
    <dbReference type="KEGG" id="bla:BLA_0669"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.697"/>
    <dbReference type="HOGENOM" id="CLU_009600_0_3_11"/>
    <dbReference type="OMA" id="EVSCPHF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="30"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL28962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="514" mass="54856" checksum="FEE3E2ED7ADECF84" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSL0</accession>
    <name>B8DSL0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative nucleoside hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">iunH</name>
        <name evidence="4" type="ordered locus">BLA_0696</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219085.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0696"/>
    <dbReference type="EnsemblBacteria" id="ACL28989">
        <property type="protein sequence ID" value="ACL28989"/>
        <property type="gene ID" value="BLA_0696"/>
    </dbReference>
    <dbReference type="GeneID" id="66533829"/>
    <dbReference type="KEGG" id="bla:BLA_0696"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.726"/>
    <dbReference type="HOGENOM" id="CLU_036838_3_0_11"/>
    <dbReference type="OMA" id="HFNGGNI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="PTHR12304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="SSF53590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IU_nuc_hydro" evidence="3">
        <location>
            <begin position="4"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="317" mass="34077" checksum="7F747186D53FC5F0" modified="2009-03-03" version="1">MKKLILDLDTGVDDALAISYALGSPEVELIGITGTYGNVLMEQGVRNALAITELLGHPEVPVYKGLPHASTKDSFEVLPISAFIHGENGIGDAVIPDPQRDAETEPAVDFIIDAVKTYGDDLVYVPTGPQTNIAAAFRKAPEIAEQLGKIVLMGGALTVPGNVNAWTEANISQDPDAADYVFRHTKDATMIGLDVTLQTLLTYKETQRWRDLGNAAGTFLADMTDFYIKAYETTAPHLGGCGLHDPLAVGVAVDPTLVTVHPINMKVDVEGPTRGRTIGDEDRLNDPHKTMGAALDVDVPRFLDEFMTRITNVAKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSL7</accession>
    <name>B8DSL7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Possible NADPH-flavin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_0703</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the flavin oxidoreductase frp family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219369.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0703"/>
    <dbReference type="EnsemblBacteria" id="ACL28996">
        <property type="protein sequence ID" value="ACL28996"/>
        <property type="gene ID" value="BLA_0703"/>
    </dbReference>
    <dbReference type="GeneID" id="66533897"/>
    <dbReference type="KEGG" id="bla:BLA_0703"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.733"/>
    <dbReference type="HOGENOM" id="CLU_070764_0_0_11"/>
    <dbReference type="OMA" id="GMCLGYP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016446">
        <property type="entry name" value="Flavin_OxRdtase_Frp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43425">
        <property type="entry name" value="PTHR43425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005426">
        <property type="entry name" value="Frp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="4">
        <location>
            <begin position="14"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="258" mass="28895" checksum="111EE96091D57166" modified="2009-03-03" version="1">MAKIIHNDTVDVLLERVSIRAFKDEAIGLDVLNTIEQAAQNTASSQYLNDWSAIRIKDPAVKTEIARICNQDYIANAPVLYIFVLDQYRNSLIAQSEGVAVDSDEFTLKNSYRFSQAQNDAVLALHAMETAAESFELGTVILGSILGNIPELVKLLALPKYTYPVLGLALGKPDQHPDPKPRLPRDIQFFDDSYNAEPNRILDGIREYDREVQAYYDTRGKDLSERAYSDMTTKKATSTAALEMGFEHARAQGFDLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSM7</accession>
    <name>B8DSM7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable cation-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ctpE</name>
        <name evidence="7" type="ordered locus">BLA_0713</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0713"/>
    <dbReference type="EnsemblBacteria" id="ACL29006">
        <property type="protein sequence ID" value="ACL29006"/>
        <property type="gene ID" value="BLA_0713"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0713"/>
    <dbReference type="HOGENOM" id="CLU_002360_5_1_11"/>
    <dbReference type="OMA" id="RLGRKQC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="620"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="651"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="684"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="721"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="752"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="784"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="832" mass="90061" checksum="DD005E796950FFFB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSN8</accession>
    <name>B8DSN8_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine recombinase XerC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">xerC</name>
        <name evidence="13" type="ordered locus">BLA_0724</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 'phage' integrase family. XerC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0724"/>
    <dbReference type="EnsemblBacteria" id="ACL29017">
        <property type="protein sequence ID" value="ACL29017"/>
        <property type="gene ID" value="BLA_0724"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0724"/>
    <dbReference type="HOGENOM" id="CLU_027562_9_0_11"/>
    <dbReference type="OMA" id="QAFWYLI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="7 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="12">
        <location>
            <begin position="34"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="11">
        <location>
            <begin position="140"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="9">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACL29017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="344" mass="38397" checksum="4F65ABD075ABA8EB" modified="2009-03-03" version="1">MSRIWSWMRVVCTDHSTGSRVCWIAQSHEMEGAMDAQVLMERFIEYLRSNRGLSEHTCMAYRGDILQCLEALDAFGRGNPDDVTLDDLRMWMGRMAHTVGKTSLARKTIAVRSFFTWAYEHGMLAHNPAHALRTPKIDRNLPAVLNEDQAERLMDTVDAEAGEKNAGKSKDDALNAHAKALRDCAMLELLYATGMRVGELVGLDMGSFDWSNRTVRVLGKGNKTRVIPFGAPAQQAVEHWLHGGRPVFANGNSGNAVFIGVRGCRIDQRVVRQVVHEQAEQAGVPDISPHALRHSAATHMLDGGADLREVQEMLGHSSLQTTQRYAHVSIEQLKDRYRQAFPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSQ2</accession>
    <name>B8DSQ2_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation initiation factor IF-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">infC</name>
        <name evidence="8" type="ordered locus">BLA_0738</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the IF-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218697.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0738"/>
    <dbReference type="EnsemblBacteria" id="ACL29031">
        <property type="protein sequence ID" value="ACL29031"/>
        <property type="gene ID" value="BLA_0738"/>
    </dbReference>
    <dbReference type="GeneID" id="66533499"/>
    <dbReference type="KEGG" id="bla:BLA_0738"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.769"/>
    <dbReference type="HOGENOM" id="CLU_054919_1_0_11"/>
    <dbReference type="OMA" id="RNMIMFL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00080">
        <property type="entry name" value="IF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF3_N" evidence="7">
        <location>
            <begin position="13"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="IF3_C" evidence="6">
        <location>
            <begin position="90"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="224" mass="25113" checksum="497ED60447D69499" modified="2009-03-03" version="1">MRNGVIISDEPRINDEIRVSQVRLIGPNGEQVGVIATSVALNLAKEANLDLVEVAPNAKPPVAKLIDYGKFKYNEKIKQREARRNQSTAEIKEIRFRLKIDDHDFEVKKGHVERFLNAGDKVKVTIMLRGREQSRPIGGVEMLQRLAEEVSDLGTVEHAPKQEGRNIIMTLAPKGKKVHTQSEQRRRGAESRAERQARQAARLAAKQEAKAEEAKEAQAAIDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSQ9</accession>
    <name>B8DSQ9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma-E factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sigH</name>
        <name evidence="8" type="ordered locus">BLA_0745</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0745"/>
    <dbReference type="EnsemblBacteria" id="ACL29038">
        <property type="protein sequence ID" value="ACL29038"/>
        <property type="gene ID" value="BLA_0745"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0745"/>
    <dbReference type="HOGENOM" id="CLU_047691_1_1_11"/>
    <dbReference type="OMA" id="NAKAWLF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="48"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="151"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="267" mass="30185" checksum="4B4094086051A0C8" modified="2009-03-03" version="1">MFAPPAGFQISFTSYRTMEGVSETSENEHETMQEKRARFEKLAMPAVNALYRQAMKFTNNPEDAQDLVQDTFERGFKAFDTFKPGSNFEAWMTTIERNAFFNQYAKAKRRPQRANDSTGEYDDWDIFAASEHTSQGLQSAEQQYLEAFAPEEIMAALDRLPPERRQVFIDAAIDGKSYQQVADEQGIKIGTVMSRLNRARTQLRKELAEYAAARGYGKSTKTSRGTSTAKAKRGNKTEANSVETNSNETRDDAREKELVGAHGKARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSS0</accession>
    <name>B8DSS0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein in PfkB family of sugar kinases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619825.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0756"/>
    <dbReference type="EnsemblBacteria" id="ACL29049">
        <property type="protein sequence ID" value="ACL29049"/>
        <property type="gene ID" value="BLA_0756"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0756"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.787"/>
    <dbReference type="HOGENOM" id="CLU_027634_6_3_11"/>
    <dbReference type="OMA" id="GAWPEYP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="20"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="298" mass="32336" checksum="38FE01B5560CE1E9" modified="2009-03-03" version="1">MSKPIVVSLGELLWDMLPTGKRAGGAPVNFAYHATNNGCEAYAGSAVGEDELGDELAIAAEKAGIHAVLQRNAWPTGTVEVALKNGIPEYTIVENVAWDHISYTRQLIDIVEQADAVCFGTLAQRSPESHDTIIELLKHTKDGALKFFDINLRGDMYSKELIEEMLSYANVFKINDEELLLMRGMFGIENTSDEEACKWFIEQFDLRYLILTGGATFSTIMSNDGEVSTLATPHVTVADTVGAGDSFSGTFTGRILNGDSLGLAHRAAVNTAAFVCTQEGAWPTYPAEITDYLAEIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>B8DST3</accession>
    <name>B8DST3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218657.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29062">
        <property type="protein sequence ID" value="ACL29062"/>
        <property type="gene ID" value="BLA_0769"/>
    </dbReference>
    <dbReference type="GeneID" id="66533531"/>
    <dbReference type="KEGG" id="bla:BLA_0769"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.801"/>
    <dbReference type="HOGENOM" id="CLU_2697158_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="73" mass="8353" checksum="B7CD8C08A664B0B8" modified="2009-03-03" version="1">MSDREPRYRNTQVLEGNAGADYTQPAYARYATRVKPDAGPYDPVNRDDPERTIIIRDRVLLTGDYLNPIVDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DST7</accession>
    <name>B8DST7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell division protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsQ</name>
        <name evidence="5" type="ordered locus">BLA_0774</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619828.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0774"/>
    <dbReference type="EnsemblBacteria" id="ACL29066">
        <property type="protein sequence ID" value="ACL29066"/>
        <property type="gene ID" value="BLA_0774"/>
    </dbReference>
    <dbReference type="GeneID" id="66533536"/>
    <dbReference type="KEGG" id="bla:BLA_0774"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.807"/>
    <dbReference type="HOGENOM" id="CLU_047677_0_1_11"/>
    <dbReference type="OMA" id="EWVSEQK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005548">
        <property type="entry name" value="Cell_div_FtsQ/DivIB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013685">
        <property type="entry name" value="POTRA_FtsQ_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03799">
        <property type="entry name" value="FtsQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08478">
        <property type="entry name" value="POTRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA_1" evidence="4">
        <location>
            <begin position="260"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="FtsQ" evidence="3">
        <location>
            <begin position="342"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="460" mass="50360" checksum="95477A0128B83A1E" modified="2009-03-03" version="1">MARRTVSSSGHSPDSQRQEPQWPRGRSVRSAGSGNRAVRSRRDMPESPTRDNTAAVRDDEQPPTQSQSFEEYPKAMRGRQARSGRSAKAARSVRAGKERRVRGGQSRTVEPRTATSGTHDAERQSASGESTQVSSGPNDSAKRPRYRFRKLVRKRRRESERTARTAQSSQSKAVSAPGSFVDARALESEDLVARTLDESAGTIGVATRPKVVDFKERQRERKTANLRVLAMRIGIGAVVFALVIALIWLLFFSPALRLRQDRITVMGANEWVNRTQILDIAKQQAGKSLLIVSDKSVEQQLDDIPGVSSSRATKKFPNGLEVEVTAQRPAAMLKVAGKDGLTAVDNQTRVLNSVTNQAVKGIPVIEVKNIDDALGQRSVRAAVTILDAMPESWRTRVTAVSANTQDSVTTTLDNGITIVWGDSAELKLKMAIVDKIMNDPNVIGDKKQINVSAPGRPIIK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSU7</accession>
    <name>RSMH_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="1">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsmH</name>
        <name type="synonym">mraW</name>
        <name type="ordered locus">BLA_0784</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218638.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DSU7"/>
    <dbReference type="SMR" id="B8DSU7"/>
    <dbReference type="STRING" id="442563.BLA_0784"/>
    <dbReference type="EnsemblBacteria" id="ACL29076">
        <property type="protein sequence ID" value="ACL29076"/>
        <property type="gene ID" value="BLA_0784"/>
    </dbReference>
    <dbReference type="GeneID" id="66533546"/>
    <dbReference type="KEGG" id="bla:BLA_0784"/>
    <dbReference type="HOGENOM" id="CLU_038422_0_0_11"/>
    <dbReference type="OMA" id="NPAKRTF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000386746" description="Ribosomal RNA small subunit methyltransferase H">
        <location>
            <begin position="1"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="39"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="353" mass="38853" checksum="03A6CA1DA6AEA4BC" modified="2009-03-03" version="1">MTDFSQIHKPVLLQECVDLVTPALHASDSVAVDCTLGLAGHTIAFLKAAPNATVIGIDRDEEALDKATARIAQEGLSARFVPVHAAFDQFDEVLRAQGVSRVQAVFMDLGLSSLQIDERERGFSYAHDAPLDMRMDTSQALTAREILATYDADRLAHIFKEYGEERFSKPIAKRIVQQRQSSPLETSSQLTALVDAVIPAARRGSGNPAKRVFQALRIEVNGELDKLRRTLPQIGLHLAVGGRLVVESYHSLEDRTVKNFMAQGLRVDAPADMPVIPPDMQPFFKALTKGAVKADAGEIAYNPRSASVRLRAVELTRPLPQRWVHAFELESQGSEDGVRGAHGHRRRTQARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSY2</accession>
    <name>B8DSY2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-(1-2)-fructofuranosidase</fullName>
            <ecNumber evidence="7">3.2.1.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cscA</name>
        <name evidence="7" type="ordered locus">BLA_0819</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.26" evidence="7"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218587.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0819"/>
    <dbReference type="CAZy" id="GH32">
        <property type="family name" value="Glycoside Hydrolase Family 32"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29111">
        <property type="protein sequence ID" value="ACL29111"/>
        <property type="gene ID" value="BLA_0819"/>
    </dbReference>
    <dbReference type="GeneID" id="66533581"/>
    <dbReference type="KEGG" id="bla:BLA_0819"/>
    <dbReference type="HOGENOM" id="CLU_001528_7_0_11"/>
    <dbReference type="OMA" id="WMGVPDG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004564">
        <property type="term" value="F:beta-fructofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_32N" evidence="5">
        <location>
            <begin position="57"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_32C" evidence="6">
        <location>
            <begin position="371"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="532" mass="59444" checksum="91D180C5801F5352" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT04</accession>
    <name>B8DT04_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0841</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218554.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0841"/>
    <dbReference type="EnsemblBacteria" id="ACL29133">
        <property type="protein sequence ID" value="ACL29133"/>
        <property type="gene ID" value="BLA_0841"/>
    </dbReference>
    <dbReference type="GeneID" id="66533603"/>
    <dbReference type="KEGG" id="bla:BLA_0841"/>
    <dbReference type="HOGENOM" id="CLU_048271_1_0_11"/>
    <dbReference type="OMA" id="VACEPYV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07208">
        <property type="entry name" value="Pat_hypo_Ecoli_yjju_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037483">
        <property type="entry name" value="YjjU-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="10"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="41"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="166"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="285" mass="31754" checksum="3E322D640ECB45A4" modified="2009-03-03" version="1">MTHTAHTTGIIDVGGGFRAIFGAGVEDRCLEEDVGFDHCYGISAGSANLASYLARQQGRAHTFYTQYAFRKEYASMENYITKRNFCDLDYVYGTLSNSDGENPLDYAAFSDNPATFTVVAANGEDGSSRYFDKSDMRQDDYTILKASSAVPVACQPVVIDDVPYFDGGIADPIPVQRAIDDGCDRIVVVLTRPVDVAREQQRDVAPARILKRHHPAAAERLLNRYRTYNDEVALARRYEQEGKVLILSPESLYGLSTMSKTFEGLERMYRAGYAQAARIREFLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT07</accession>
    <name>B8DT07_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP binding protein of ABC transporter for glutamate/aspartate</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gltL</name>
        <name evidence="5" type="ordered locus">BLA_0844</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218548.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0844"/>
    <dbReference type="EnsemblBacteria" id="ACL29136">
        <property type="protein sequence ID" value="ACL29136"/>
        <property type="gene ID" value="BLA_0844"/>
    </dbReference>
    <dbReference type="GeneID" id="66533606"/>
    <dbReference type="KEGG" id="bla:BLA_0844"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.879"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OMA" id="RCIPFLE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="18"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="297" mass="32607" checksum="D93EB2FAFA2B2DBB" modified="2009-03-03" version="1">MTERTDSVATAPADVPALQVTDLLKHYADADRNVFDGISFSVPKGKVLVIVGPSGSGKSTLLRAIAGLEPIQGGTIALDGQVIETGKPGNEKSGRAKRPESLRTKFGMVFQSYELFPNKDVLGNITMAPMLVQKRKKAEVEREAMELLDRVHLADRAQAKPHELSGGQRQRVAICRALILHPEILLLDEITAALDPEMVHEVLEVVVELADAGQTMLIVTHEMQFARAIADRVILLADGQIADRSTNAEQFFTDPQTERAKEFLHSFDFERHRSAQAHERLEAFDEDGTGDGQSAHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT18</accession>
    <name>B8DT18_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0855"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29147">
        <property type="protein sequence ID" value="ACL29147"/>
        <property type="gene ID" value="BLA_0855"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0855"/>
    <dbReference type="HOGENOM" id="CLU_025996_0_9_11"/>
    <dbReference type="OMA" id="FNHMTVM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="72"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="369" mass="42132" checksum="605BDECD03B6FC72" modified="2009-03-03" version="1">MAHGAYADMRAEYAHSIHAMQPRLMAELPPPWFTIGCMTHRERRETTAPFTLLMAVYGGNSLREVERSVQSSTIEQTLPPNQVVIVRDGPVQEPVQRYLDTLQSTMAVWFTAERPELEVPEVTIVPLDENRGLAHALNIGLQHCDFDVVARADCDDVSLPNRFATIIPQFTRRSAASHTTVKSKLPIDVMGSAIREFTDDERQPGQIRMLPAEGADLEKYARMQSPVHHPSVVFRKSAVLAAGGYPEDAGRFEDYLLWERMMLNHAQFLNMPEPLVLYRTNQEAYERRGGWDMFREELRLQWRFLRDGFTSPAQFLRNTFIRAAYRMMPTSLRKRAYHSIVSRRNTEISAAPAPAEVQAKPRGRHAQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT22</accession>
    <name>B8DT22_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0859</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29151">
        <property type="protein sequence ID" value="ACL29151"/>
        <property type="gene ID" value="BLA_0859"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0859"/>
    <dbReference type="HOGENOM" id="CLU_014385_0_0_11"/>
    <dbReference type="OMA" id="NIEYQAL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="3">
        <location>
            <begin position="262"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="660" mass="73268" checksum="3D3B742C86429BAB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT31</accession>
    <name>B8DT31_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PS_pyruv_trans domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269243.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0868"/>
    <dbReference type="EnsemblBacteria" id="ACL29160">
        <property type="protein sequence ID" value="ACL29160"/>
        <property type="gene ID" value="BLA_0868"/>
    </dbReference>
    <dbReference type="GeneID" id="66533846"/>
    <dbReference type="KEGG" id="bla:BLA_0868"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.906"/>
    <dbReference type="HOGENOM" id="CLU_050032_0_0_11"/>
    <dbReference type="OMA" id="RLCWEAP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PS_pyruv_trans" evidence="1">
        <location>
            <begin position="47"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="442" mass="48302" checksum="4B0CEE46B01E70C4" modified="2009-03-03" version="1">MKAAKRAFWEQITRLYNRHYGVKPLPETEIVRRSKCHYLIGEAGYPNYGDELIAREWVKYLAQVDPEVPVVLDCLCAGPAAAICSGLHPKFSVVDTVAQMCMIDRAHIYDEQHAVSDSVEPAAAVAPTIEEIPVPQIANRVLAALDAEGLDARYAAGIRLLNNRALDMHVIGGGYMHSFWNANLARLAVAKWAQAHGKPAVVSGVGLEPLDAEDAEWVADIASHITAFSCRDMPSLDAIDSSHSYATLAPDDCFVNGLEGVYLPDEAAGDLPETMVCVQTDLVPDPAALLDHMVAVLQAWEAPAGERVGVVECIPYDSMDALRVIRDHGWEPVLFPLQNLIDHGFPARSGQRWLSTRYHPHLLAAARGCSGTFIPVKPGYYDVKHAAVLRMGSRWTQTTIGDSLIPKPGPGFADPSVRFAYRDQIRAQVAPLYGEPHSFVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT63</accession>
    <name>B8DT63_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_0900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219267.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0900"/>
    <dbReference type="EnsemblBacteria" id="ACL29192">
        <property type="protein sequence ID" value="ACL29192"/>
        <property type="gene ID" value="BLA_0900"/>
    </dbReference>
    <dbReference type="GeneID" id="66533880"/>
    <dbReference type="KEGG" id="bla:BLA_0900"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.942"/>
    <dbReference type="HOGENOM" id="CLU_037628_6_4_11"/>
    <dbReference type="OMA" id="ITSWFNT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="341" mass="37971" checksum="691F09ECA0235FFB" modified="2009-03-03" version="1">MHKAGIRDVAREAGVSISTVSRAFTKPQLVSQATRDRVMAAANKLDFNISRSAMALKSGQTYRVALLMSEGITSWFNAEVFAGIDDVMHGKGYDISLYQHINDAETRDRFFTVLPVLRNVDAVFVASFAIEPAEIEQLRRTKVPIVGINTPDPLRFDASETIDDEGGMYRAAQHMIKLGHKRIVYTCSAAAETLDASIDLRGHGFIRACERAQNTHDISWKVLTVPRGRDFADNALTAVLSEDRFPDAICCQMDMMAIPLMIKLARHGYRAPRDYSIIGFDDAPYADTVELTTMRQNPYEMGRNAAMKALTLLEGRALEQPHAILEPKLVLRGSDSRYEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT69</accession>
    <name>B8DT69_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative sugar-binding secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219259.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0906"/>
    <dbReference type="EnsemblBacteria" id="ACL29198">
        <property type="protein sequence ID" value="ACL29198"/>
        <property type="gene ID" value="BLA_0906"/>
    </dbReference>
    <dbReference type="GeneID" id="66533886"/>
    <dbReference type="KEGG" id="bla:BLA_0906"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.948"/>
    <dbReference type="HOGENOM" id="CLU_031285_17_3_11"/>
    <dbReference type="OMA" id="NGPWAVR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870760" evidence="2">
        <location>
            <begin position="34"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="419" mass="44606" checksum="DAC715AC0A167F51" modified="2009-03-03" version="1">MKIEWKKAVGLAAAVAMIVPMAACGANGGDSNAADGSKPSETQSANLTVWGPSEDSEWLKDMEEAFGKAHPEYKVTWKNSVVAEGDAAKTVKTDPTAAADVYMFANDQLGDLLDQNAIAPVNDVVAQQVKEQNSQTMVDSVTGTDGKIYGVPYTSNTYFMYYNKDKFSADDVKSLDTMLEKGKVAYPLSNSWYIPAFYLGAGMTMFGPKGTDAKAGIDFGPNADAVSEALVKLVANPNFTNDDGTLGLAGLKNGTLDAYFSGSWDAANVQKALGDKYGAATVPTFKAGDKDYQMKALAGSKAIGMNPNTKAPEVASAFAAFLGSTEAQKKHWEMRQIIPSDKTLTNLEGMSTSPYVQAQLDTIAKTSVAQPTISAMSAWWTPAETFGKALVSKQVNDGNVKQKTADFMASVKKDVANKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT85</accession>
    <name>B8DT85_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217577.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0922"/>
    <dbReference type="EnsemblBacteria" id="ACL29214">
        <property type="protein sequence ID" value="ACL29214"/>
        <property type="gene ID" value="BLA_0922"/>
    </dbReference>
    <dbReference type="GeneID" id="66533464"/>
    <dbReference type="KEGG" id="bla:BLA_0922"/>
    <dbReference type="HOGENOM" id="CLU_055441_0_0_11"/>
    <dbReference type="OMA" id="QPFITTC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="426" mass="46340" checksum="9223D802066CF1F1" modified="2009-03-03" version="1">MWSTFLNTMRVNLREKSSVFWLFCFPIILSTMFMGMFGNIGEVYEIHTMRFAVVADANFCRATNARQMLHAMQRNPLRNEGCGNAMEGAAPDTASGQVGSELRNLLELQAVSNVKEAKGLINADHGVRGYINATEDGLLNLTISRASVASVNDDTGNSGFSASLNILHGAVGMFNRRAITVTELLNTDSGVFRDATFTKEMGDTPTFTKVVSPTHFKPTESVRFYYALLAMTALMSMTFATTTVCATQANLSALGMRRSLAPLSKFNQLMGGFLASWLCASVSMVVATLYVHFVCKVDFGGRWPVLVLALLLASLTANALGTLIGSLPKLTSGVKIGITTALSCVLSIFSGLYGTGAMNLSDWTQRNAPGFAIVNPTQQITNLFYDLLHYDSYAPSLRTSGILLAMTVLALTLSTIFLRRQRYEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT98</accession>
    <name>B8DT98_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Regulatory protein RecX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_0935</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619881.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0935"/>
    <dbReference type="EnsemblBacteria" id="ACL29227">
        <property type="protein sequence ID" value="ACL29227"/>
        <property type="gene ID" value="BLA_0935"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0935"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.978"/>
    <dbReference type="HOGENOM" id="CLU_066607_1_0_11"/>
    <dbReference type="OMA" id="DYCEENS"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003783">
        <property type="entry name" value="Regulatory_RecX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33602">
        <property type="entry name" value="PTHR33602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02631">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="209" mass="23532" checksum="5ADEC80E9626321B" modified="2009-03-03" version="1">MISAEEFLSSHEQMVREPSAPNSSNRDVPGKHPTKERRRKLSGGFAYSVAADSHDEDECKESALRLLDAAARSSGSLRDKLVEREYDAEVIDRVVARLEELGLIDDEEYARNVIRSCTARMMGARGVIRELVRKGVPRPLAERMVRETAQAGVFEDCAWELGRTVAKKNAGKDVEVCKRRFWSAGGRKGHAPEDLRAVSDELFLRRIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTB0</accession>
    <name>B8DTB0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter, putative fucose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BLA_0947</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0947"/>
    <dbReference type="EnsemblBacteria" id="ACL29239">
        <property type="protein sequence ID" value="ACL29239"/>
        <property type="gene ID" value="BLA_0947"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0947"/>
    <dbReference type="HOGENOM" id="CLU_021993_2_0_11"/>
    <dbReference type="OMA" id="AHGSYGV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="43"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="431" mass="46406" checksum="2DB199D6E0B66C09" modified="2009-03-03" version="1">MGTSLIIEQISKNRIFSLRKKIIMGCRCRNWRTLFGGAMTNLLLAVIYLAFISLGLPDGLLGSAWPTMSGDLHAPLSRAGGISMTISAGTIISALLSDRLTLRFGAGRVTAFSVALTAAALMGFSFAPNYWVLIVCAIPYGLGAGGVDAALNNYVAIHYTSRHMSWLHCMWGLGALIGPYMMSYAMASRHGWQWGYRSVGVIQLVLTAVLIFSLPLWKRRPAAADAGTQATDRKPIGLLGVLRISGATQILIMFFCYCAIEQTAMLWASSYMVGMDGMAEDVAATFTSIFLIGITVGRFANGFLTMRFSDPAMIRIGTMTIGLGALLLLVPVHNPALSAVAFILVGLGCAPVYPCIIHSTPTYFGADKSQAIVGVQMAFAYVGTMLMPPLFGVIAQATTIAVLPWCLLVFVAFMAAMHEWLRALRRDDMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTD2</accession>
    <name>B8DTD2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Predicted chloride channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_0971</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29261">
        <property type="protein sequence ID" value="ACL29261"/>
        <property type="gene ID" value="BLA_0971"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0971"/>
    <dbReference type="HOGENOM" id="CLU_015263_0_0_11"/>
    <dbReference type="OMA" id="GPLTMTF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="433" mass="45109" checksum="6E8C288C515DCDA8" modified="2009-03-03" version="1">MANTRADATGEGRPPVVSRAFSLLVSTLVLGALIGICAGLLTLLLYAIEHLCLGFVEHPELPGPFLTPAWRRAASVFGGASVAAIAWWALRTKSKAVPSVKQAVAGRLMPIWQTVAHVLLQIFIVGTGLSVGREVAPRELGAMLAQRCARMLRLNPTDMRTIVAVTAGAGLAGVYNAPLAGAFFAVEILLVDVSGGTVILSFLCSTLAAWVATLVKGTHTFYVIGHVDAHFSWDLMVFAIPAGVILGVCGALFRKGSQWAERNKAAGNAILWMLPLAGAVTGIVAIRIPQVMGNGRATAQLAFSGTPTMSLIPLLLLSFAAKALITLFTIRAGASGGVLTPGIALGASMGCILGILWMQMTGTNSIGVYALLGACALLSASQNAPLMAMCLVMELTEAPMNLFVPVVFISMISLLASHATLSVVERRSVTVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTD4</accession>
    <name>B8DTD4_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5 8">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 11" type="primary">clpP</name>
        <name evidence="11" type="ordered locus">BLA_0973</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 9">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 10">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5 8"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217639.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0973"/>
    <dbReference type="MEROPS" id="S14.009"/>
    <dbReference type="EnsemblBacteria" id="ACL29263">
        <property type="protein sequence ID" value="ACL29263"/>
        <property type="gene ID" value="BLA_0973"/>
    </dbReference>
    <dbReference type="GeneID" id="66533416"/>
    <dbReference type="KEGG" id="bla:BLA_0973"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1016"/>
    <dbReference type="HOGENOM" id="CLU_058707_3_2_11"/>
    <dbReference type="OMA" id="GFKRQDP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL29263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="233" mass="25805" checksum="D73BC97A6BE53FE1" modified="2009-03-03" version="1">MASEEAQFVARAERLAGPAGIAGFQPAAARDRALAAQNRYVVPEFTERTPYGMKTQNPYTRLFDDRIIFLGVQVDDTSADDIMAQLLVLESMDPNRDVMMYINSPGGSMTAMTAIYDTMQYIKPDVQTVCLGQAASAAAIILAAGTKGKRLMLPNARVLIHQPAIDQGFGKATDIEIQAKEMMRMREWLENTLAKHTGQSRERISRDIEVDTFLTASEAKEYGIVDEVLEHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTF1</accession>
    <name>B8DTF1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator of two-component system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_0990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269122.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0990"/>
    <dbReference type="EnsemblBacteria" id="ACL29280">
        <property type="protein sequence ID" value="ACL29280"/>
        <property type="gene ID" value="BLA_0990"/>
    </dbReference>
    <dbReference type="GeneID" id="66533397"/>
    <dbReference type="KEGG" id="bla:BLA_0990"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1033"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OMA" id="LDRFAPM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="8"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="167"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="234" mass="25722" checksum="D620C6AB7EACED74" modified="2009-03-03" version="1">MADASRIRMVIADDQELVRAGFTMVINSQPDMQVVGQASDGTQAVQLVERLHPDIVLMDVRMPSMDGLAATAQITSHADGEQHTRVIILTTFDLDEYVMSAINAGASGFLLKDTEPETLLNSIRTVHQGNAIIAPTATKRLIEKMMETGVTQEGPGRQQSEVAAEYTDPELATLTEREREVLIEIAHGLSNQEIADKLFISLPTVKTHVAHILQKINARDRVQAVVFAYENHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTG5</accession>
    <name>B8DTG5_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Branched-chain amino acid transport system carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">brnQ</name>
        <name evidence="9" type="ordered locus">BLA_1004</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the transport system for branched-chain amino acids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the branched chain amino acid transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217683.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1004"/>
    <dbReference type="EnsemblBacteria" id="ACL29294">
        <property type="protein sequence ID" value="ACL29294"/>
        <property type="gene ID" value="BLA_1004"/>
    </dbReference>
    <dbReference type="GeneID" id="66533383"/>
    <dbReference type="KEGG" id="bla:BLA_1004"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1047"/>
    <dbReference type="HOGENOM" id="CLU_036807_0_1_11"/>
    <dbReference type="OMA" id="IWPAGPI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004685">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_Livcs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30588">
        <property type="entry name" value="PTHR30588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05525">
        <property type="entry name" value="Branch_AA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00796">
        <property type="entry name" value="livcs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL29294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="454" mass="48458" checksum="916E67DD6273F04D" modified="2009-03-03" version="1">MGKLNPHSHKRLDTRQRIIVGITFFSMFFGAGNLIFPPYLGALAGNRTLVGMVGFVVSAVGLPILGVIVVAQAGGFGNLSARVSKRFALVLGVAIMLTIGPLFAIPRTASTSFEMAVVPFAGQQNLWLVRLLYSLVFFGLAFLVAQHPDKLSQVLGKVMGPLLLVMIVVLFAACLFAKHPGFANPQGSYAHHQLMQGFIDGYQTMDLLAGLYFGIVISANISSMGVEDEHDNRAETGIGGIFTGIMLAIIYAMLGFVGAVSGSYQAIDGATDTGATVLTNLTDRLFGHVGTMFVGLIFIVACFNVCSGLLSTCSSYFHKQFGTVLGYRGWTIVFTLIALVIANIGLSAIIKLSVPVLEALYPIAIVLVLLSLLHGVFTRHFPAVYFWTVLFTAIDSVANGIANLVAAFGGRLVWLETACNWLPLNSVALGWVVPALAGFVVGIIVSIAERMHTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTH2</accession>
    <name>B8DTH2_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ferrous iron transport protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">feoB</name>
        <name evidence="14" type="ordered locus">BLA_1011</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probable transporter of a GTP-driven Fe(2+) uptake system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217690.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1011"/>
    <dbReference type="EnsemblBacteria" id="ACL29301">
        <property type="protein sequence ID" value="ACL29301"/>
        <property type="gene ID" value="BLA_1011"/>
    </dbReference>
    <dbReference type="GeneID" id="66533376"/>
    <dbReference type="KEGG" id="bla:BLA_1011"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1055"/>
    <dbReference type="HOGENOM" id="CLU_013350_3_2_11"/>
    <dbReference type="OMA" id="PLGYDWK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01879">
        <property type="entry name" value="FeoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003373">
        <property type="entry name" value="Fe2_transport_prot-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011640">
        <property type="entry name" value="Fe2_transport_prot_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030389">
        <property type="entry name" value="G_FEOB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07664">
        <property type="entry name" value="FeoB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02421">
        <property type="entry name" value="FeoB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00437">
        <property type="entry name" value="feoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51711">
        <property type="entry name" value="G_FEOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0410">Iron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="626"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="657"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="FeoB-type G" evidence="13">
        <location>
            <begin position="46"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACL29301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="683" mass="74278" checksum="E4545657A99B6C4A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-12-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTH6</accession>
    <name>B8DTH6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein, MarR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">marR</name>
        <name evidence="2" type="ordered locus">BLA_1015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29305">
        <property type="protein sequence ID" value="ACL29305"/>
        <property type="gene ID" value="BLA_1015"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1015"/>
    <dbReference type="HOGENOM" id="CLU_083287_30_1_11"/>
    <dbReference type="OMA" id="QRAICEY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="155" mass="18065" checksum="52C09C356C088118" modified="2009-03-03" version="1">MIEHAQAAHSDLDTQLIAFFEEFRRVDLIYGAYGRRSGLLFSVYLIFDYIRENDGTSQREICAYTLLPRQTVNNVFNSLVAQGLLRLQGSKHDKRIKRIHLTEEGERYRERMIAPLRQAEVRAMPTLEPAERRAMITYVDRFMNALEQQIDGIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTJ5</accession>
    <name>B8DTJ5_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fkbP</name>
        <name evidence="6" type="ordered locus">BLA_1036</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217723.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1036"/>
    <dbReference type="EnsemblBacteria" id="ACL29324">
        <property type="protein sequence ID" value="ACL29324"/>
        <property type="gene ID" value="BLA_1036"/>
    </dbReference>
    <dbReference type="GeneID" id="66533352"/>
    <dbReference type="KEGG" id="bla:BLA_1036"/>
    <dbReference type="HOGENOM" id="CLU_013615_12_0_11"/>
    <dbReference type="OMA" id="FTSMNNQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="5">
        <location>
            <begin position="45"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="135" mass="14343" checksum="39B705A082C58F0F" modified="2009-03-03" version="1">MATDMPVVKGAFGDTPQIEFPSEQAPQGLKVVELEEGNGPIVRRGDTVTVNYHGQVWGNDKAFDSSFERHHPASFGIGVGQVIKGWDQTVPGHNVGSRLLISIPPQYGYGANGAPQAGIGGDDTLVFVVDIISTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTJ8</accession>
    <name>B8DTJ8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine kinase-like protein</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1039"/>
    <dbReference type="EnsemblBacteria" id="ACL29327">
        <property type="protein sequence ID" value="ACL29327"/>
        <property type="gene ID" value="BLA_1039"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1039"/>
    <dbReference type="HOGENOM" id="CLU_045351_1_0_11"/>
    <dbReference type="OMA" id="GSIAIVH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038424">
        <property type="entry name" value="H_kinase_PdtaS_GAF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022066">
        <property type="entry name" value="PdtaS_GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011495">
        <property type="entry name" value="Sig_transdc_His_kin_sub2_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12282">
        <property type="entry name" value="H_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07568">
        <property type="entry name" value="HisKA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="309"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="509" mass="56726" checksum="17776B6B620B6D18" modified="2009-03-03" version="1">MRICVAVLVRVAGYDEAMADFSQILATRPDFDDSDREWLHHLVADWQVIADLSFADLLLILQKGDGSYIFAEQCRPSTVVSMRVDDVVGQQVDAWMRNECEAAMQHDGVYRSQNLQHIDGMNICNTYAPIRHNGKTLGLVLRETNLENRESNGRYEWESLEVGRQLFAMITREQFPYRDAVMNQRHNARVSDGFMRLTVDGDVTYASPNAISCFRRLGMVDMMQGKNLGEVGAGLIHQNDPVPESLPLVLLGKAPVDSELNANHSVVSIRSMPLMDGHGRTGAIVLCRDITELRRREVELQTKDATISEIHHRVKNNLQAVSALLRLQARKTKSQEVKKELQEAMRRVQTIAMVHEGLSQTADENVDFDKVISNLLRMSVDLASMRDQHITIDFVGKFGKMPAQDATPLSLVLTELITNAVEHGYDGRKEGHITVSVGREGKCLNVVVEDDGNGMDQEESNGMAKASGSGLGTQIINTFVTNDFGGNVRWEHGRDGGTRVILDMTLRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTL7</accession>
    <name>B8DTL7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Possible undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rfe</name>
        <name evidence="7" type="ordered locus">BLA_1058</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218752.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1058"/>
    <dbReference type="EnsemblBacteria" id="ACL29346">
        <property type="protein sequence ID" value="ACL29346"/>
        <property type="gene ID" value="BLA_1058"/>
    </dbReference>
    <dbReference type="GeneID" id="66532887"/>
    <dbReference type="KEGG" id="bla:BLA_1058"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1106"/>
    <dbReference type="HOGENOM" id="CLU_023982_2_2_11"/>
    <dbReference type="OMA" id="MCLGFLP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="386" mass="41946" checksum="E6DD43A382BC713D" modified="2009-03-03" version="1">MRAYIFIAMVAMVATYLYTPLIRHLAIQLGAVGEVRARDVHTVPTPRMGGVAMLLGFITAMFFASRLNFLQGEFRQNHQAWVVMAGAAMICLLGVADDVWDLDWMLKLAGQLLISVFVAWGGLQIISLPIGGLLTASPMISIAITALLIVVSINAVNFVDGLDGLAAGIVAIGGIAFGIYSYVLSRQQVSYASMATLVDVAMVGICLGFLLHNWHPAKLFMGDSGSMLLGYLITCASIIITGRLDPATINTSAYVPAFMPILLPVLVLFLPVLDMLMAITRRLRKGQSPMHPDRMHLHHRMLRIGHTVQGAVLILWGWAALIAFSSMFLLFFRFVDVLIGFVVLAVLLTIATLYPYFKRMGPGAHSNDGVLPKSNAPKHVQESGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTV1</accession>
    <name>B8DTV1_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Formate-dependent phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="3">6.3.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5'-phosphoribosylglycinamide transformylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Formate-dependent GAR transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">GAR transformylase 2</fullName>
            <shortName evidence="3">GART 2</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Non-folate glycinamide ribonucleotide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphoribosylglycinamide formyltransferase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">purT</name>
        <name evidence="6" type="ordered locus">BLA_1142</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + formate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24829"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (formate route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PurK/PurT family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.21" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619943.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1142"/>
    <dbReference type="EnsemblBacteria" id="ACL29430">
        <property type="protein sequence ID" value="ACL29430"/>
        <property type="gene ID" value="BLA_1142"/>
    </dbReference>
    <dbReference type="GeneID" id="66532966"/>
    <dbReference type="KEGG" id="bla:BLA_1142"/>
    <dbReference type="HOGENOM" id="CLU_011534_1_3_11"/>
    <dbReference type="OMA" id="GMVTMIT"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043815">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase 2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01643">
        <property type="entry name" value="PurT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005862">
        <property type="entry name" value="PurT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="5">
        <location>
            <begin position="123"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="5'-phosphoribosylglycinamide binding" evidence="3">
        <location>
            <begin position="26"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="5'-phosphoribosylglycinamide binding" evidence="3">
        <location>
            <begin position="384"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>N(1)-(5-phospho-beta-D-ribosyl)glycinamide</name>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="164"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="203"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>N(1)-(5-phospho-beta-D-ribosyl)glycinamide</name>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>N(1)-(5-phospho-beta-D-ribosyl)glycinamide</name>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="418" mass="44981" checksum="A9D3243AC6F0ADBD" modified="2009-03-03" version="1">MTTDSMILGTPFGEHPTRILMLGSGELGKEVTISLMRLGAWVCAADSYNGAPAAQVAHEARVLDMANADALRNVIGDVKPDIVIPEIEAIATDVLFEAEQAGIRVVPSAAIASICMDRERLRQLAADELGLPTTKFEFAGSLQELKEAATRIGFPCVVKPVMSSSGHGQSVVRSADKIEDAWNEAQTGRRAHGEGDVSRVIIEQLVDLDYELTMLTVSSSAGIVVCEPIGQRQESGDYRDSWQPAAVEPDHRQEVKRIATQAVQGLIAHAGTDTAWGVFGVELFVLKDGTVLFNEVSPRPHDTGMVTMISQYLSEFDLHARAVLGIPVSKAHIGLDLPKYYGAASHAIVVEGNGEVEFSNLQTALATPGTDLRIFSKPRVEGHRRMGVTLAIGSDIDEARIKANECAQNLRIVVNPAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTW7</accession>
    <name>RPOZ_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit omega</fullName>
            <shortName evidence="1">RNAP omega subunit</shortName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RNA polymerase omega subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Transcriptase subunit omega</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpoZ</name>
        <name type="ordered locus">BLA_1158</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase subunit omega family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218889.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DTW7"/>
    <dbReference type="SMR" id="B8DTW7"/>
    <dbReference type="STRING" id="442563.BLA_1158"/>
    <dbReference type="EnsemblBacteria" id="ACL29446">
        <property type="protein sequence ID" value="ACL29446"/>
        <property type="gene ID" value="BLA_1158"/>
    </dbReference>
    <dbReference type="GeneID" id="66532983"/>
    <dbReference type="KEGG" id="bla:BLA_1158"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1216"/>
    <dbReference type="HOGENOM" id="CLU_125406_1_1_11"/>
    <dbReference type="OMA" id="QHADSKY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00366">
        <property type="entry name" value="RNApol_bact_RpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003716">
        <property type="entry name" value="DNA-dir_RNA_pol_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34476">
        <property type="entry name" value="PTHR34476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="SSF63562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00690">
        <property type="entry name" value="rpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000133719" description="DNA-directed RNA polymerase subunit omega">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00366"/>
        </source>
    </evidence>
    <sequence length="94" mass="10368" checksum="B12A6D1802518F26" modified="2009-03-03" version="1">MAFGTEPIPTGLADPPIDDLMEHADSKYALAIFAAKRARQINSYFTQLNEGLLQNVGPLVEYKSQEKPLSIAFREINEGLLEETLGEDDLSEGN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTW8</accession>
    <name>METK_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">S-adenosylmethionine synthase</fullName>
            <shortName evidence="1">AdoMet synthase</shortName>
            <ecNumber evidence="1">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">metK</name>
        <name type="ordered locus">BLA_1159</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="1">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218890.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DTW8"/>
    <dbReference type="SMR" id="B8DTW8"/>
    <dbReference type="STRING" id="442563.BLA_1159"/>
    <dbReference type="EnsemblBacteria" id="ACL29447">
        <property type="protein sequence ID" value="ACL29447"/>
        <property type="gene ID" value="BLA_1159"/>
    </dbReference>
    <dbReference type="GeneID" id="66532984"/>
    <dbReference type="KEGG" id="bla:BLA_1159"/>
    <dbReference type="HOGENOM" id="CLU_041802_1_1_11"/>
    <dbReference type="OMA" id="MPYLRPD"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0554">One-carbon metabolism</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000196690" description="S-adenosylmethionine synthase">
        <location>
            <begin position="1"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="177"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="263"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00086"/>
        </source>
    </evidence>
    <sequence length="408" mass="44680" checksum="4EFAAE2A2038DFCA" modified="2009-03-03" version="1">MAEVKLISAESVTEGHPDKICDQISDAILDDMLRQDPHSHVAVETSATKGQFWVFGEVTSKGYSDIQSIVRDTVRRIGYTSSVIGLDADSCGVLVSLSEQSPEINQGVSRIDSDRENAVSREERYEAQGAGDQGVMFGYASDETDVLMPLPIHLAHRLAYRLAEVRKNGEVKFLRPDGKTQVTIEYDEENRPLRVDTVLISTQHDPEVSQEALREDLREHVIEPVLDEVLGDAVKHDDYRVLVNPTGSFIMGGPAADAGLTGRKIIVDTYGGAAHHGGGAFSGKDPSKVDRSAAYAARWVAKNIVAAGLAHKVEVQVAYAIGVAEPVSINVETYGTEADGVTREQIQEAVRKVFDLRPAAIVDELDLLRPIYSKTAAYGHFGREDDDFTWEHTNKVDELKRAIATLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTX6</accession>
    <name>B8DTX6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Possible inositol monophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218904.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1167"/>
    <dbReference type="EnsemblBacteria" id="ACL29455">
        <property type="protein sequence ID" value="ACL29455"/>
        <property type="gene ID" value="BLA_1167"/>
    </dbReference>
    <dbReference type="GeneID" id="66532992"/>
    <dbReference type="KEGG" id="bla:BLA_1167"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1225"/>
    <dbReference type="HOGENOM" id="CLU_044118_0_4_11"/>
    <dbReference type="OMA" id="RVDGYWE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="297" mass="33128" checksum="3B851D258A6BB3BC" modified="2009-03-03" version="1">MQAGLRELAVQVSRIAEDAGKHALKDQLMPKDLVTLNTVQRDYSRGLKVDDRLSQFIYNRLTYIDPFKGRWEDRTDEWAPGDRYWCVGGVDGVINYSRSMAEWSVTISLFEFNEFGSAQPILGVIHAPALNLTYLAARQQGAIRMRKTPVGEKREKIMPSTVSHLDGSIVSFGMSYVPQEAQHALNVVASLAGKPADIKRIGPVSLDVCKVADGTYDAYFEPHLHERDVPAISAAAVVLWEAQGQLSTWEGGLIHWRSQNDLVATNGQIIQELQPYLINSDCGESYHHHEQKPAGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU13</accession>
    <name>B8DU13_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA ATPase, central domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_1204</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218139.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1204"/>
    <dbReference type="EnsemblBacteria" id="ACL29492">
        <property type="protein sequence ID" value="ACL29492"/>
        <property type="gene ID" value="BLA_1204"/>
    </dbReference>
    <dbReference type="GeneID" id="66533029"/>
    <dbReference type="KEGG" id="bla:BLA_1204"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1266"/>
    <dbReference type="HOGENOM" id="CLU_017985_1_0_11"/>
    <dbReference type="OMA" id="RIILSQC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="58"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="463"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="504" mass="54574" checksum="C77F44368D621DED" modified="2009-03-03" version="1">MTNDLFAASDPSEEVVRPLAVRMRPTTLDEVVGQRHVLAPGSPLRRLADSASTGSLTAPSSVILFGPPGVGKTTLAHIVAKQSGRQYEELSAVTSGVKDLREVLRRAHERLVSQGKETVLFIDEVHRFSKSQQDALLPSVENRDVTFIAATTENPSFSVIKPLLSRSVVVKLESLEPEELRTVIERAVSNPRGLGGKVRVQGDAVDGIIRLAGGDARKSLTILEAAAGAVDESGSNVPAEITTDVVSTVMDVAAVRYDRNGDDHYDVISAFIKSMRGSDVDATLHYLARMIRAGEDPRFIARRIMIAAAEEVGMAAPQILQITVAAAQAVQMIGMPEARIILSEAAIAVATAPKSNASYTAINQALADVDAGLIGQVPLHIRNAPTTLMKSWGNHEGYHYAHDYPNAVVEQQYMPDVLVGREYYHPNSRGYEREIGPRLDRIRAIIHGEPAPPAPTQTERKPTEPVDPAHTEHPGETQRSQMKGKNDDATDTGRKEEDREPGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU24</accession>
    <name>B8DU24_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Morphine 6-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">morA</name>
        <name evidence="5" type="ordered locus">BLA_1215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218125.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1215"/>
    <dbReference type="EnsemblBacteria" id="ACL29503">
        <property type="protein sequence ID" value="ACL29503"/>
        <property type="gene ID" value="BLA_1215"/>
    </dbReference>
    <dbReference type="GeneID" id="66533039"/>
    <dbReference type="KEGG" id="bla:BLA_1215"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1277"/>
    <dbReference type="HOGENOM" id="CLU_023205_0_3_11"/>
    <dbReference type="OMA" id="WRHPDEP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="20"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="278" mass="31569" checksum="693BDB9799BD1959" modified="2009-03-03" version="1">MALQDGEHTIALNNEVLMPEIGFGVWHAEEGPETVNAVKAALANNYRLIDTAAFYKNEKSVGEAIASSDVPRDQIFVTTKVWNDDIRAGKTKEAFDKSLKLLDLDYLDLYLLHWPVEGWQQAWKELETLYRDGRVKAIGVCNFEQDQLEELLDLAEIKPAVNQIESNPLFANQDLIDFCHSKGIAVEAWHPMGGRGSDLFENETLRDIGDKYGKSPAQVMIRWHMQREVIPLPKSVHETRIVQNIHVFDFELGENDMARINAMDTGERQGADPHHVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU29</accession>
    <name>B8DU29_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP binding protein of ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_1220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1220"/>
    <dbReference type="EnsemblBacteria" id="ACL29508">
        <property type="protein sequence ID" value="ACL29508"/>
        <property type="gene ID" value="BLA_1220"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1220"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OMA" id="LFAHFDL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="46"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="80"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="292" mass="32023" checksum="9D9BAD708A5F0166" modified="2009-03-03" version="1">MRTPSAVRSAYRHASAHLQTTMFGMGLLTSLFKTTRPVTPPQKVGFGFDHAVYAYDAQTYGVRDISLDLSCSNGNTAIIGLNGAGKSTLIDLMNGTLTPSSGKVTVEADGKSYDASHGGRAQIQRIVGTVQREADLYRLRHNVSIEQSIDELLRKYRLTTVQRLAIAGDALAKFSLDTNMRTPLDELDGEQLHLFAIARAYAANPGVLLADEPMRGLDEISSRHVAHRLFTCGKPVVFATHNVDLIRNDEFNITRVIVMDEGEIAFDGEPASASAYYAQLIRSKYRQISSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU31</accession>
    <name>B8DU31_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218117.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1222"/>
    <dbReference type="EnsemblBacteria" id="ACL29510">
        <property type="protein sequence ID" value="ACL29510"/>
        <property type="gene ID" value="BLA_1222"/>
    </dbReference>
    <dbReference type="GeneID" id="66533046"/>
    <dbReference type="KEGG" id="bla:BLA_1222"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1284"/>
    <dbReference type="HOGENOM" id="CLU_283236_0_0_11"/>
    <dbReference type="OMA" id="DNLFYAH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="1109" mass="123069" checksum="0C5E16552208EB79" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU54</accession>
    <name>ARGC_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
            <shortName evidence="1">AGPR</shortName>
            <ecNumber evidence="1">1.2.1.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N-acetyl-glutamate semialdehyde dehydrogenase</fullName>
            <shortName evidence="1">NAGSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argC</name>
        <name type="ordered locus">BLA_1245</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.38" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619979.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DU54"/>
    <dbReference type="SMR" id="B8DU54"/>
    <dbReference type="STRING" id="442563.BLA_1245"/>
    <dbReference type="EnsemblBacteria" id="ACL29533">
        <property type="protein sequence ID" value="ACL29533"/>
        <property type="gene ID" value="BLA_1245"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1245"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1308"/>
    <dbReference type="HOGENOM" id="CLU_006384_0_0_11"/>
    <dbReference type="OMA" id="PHLTPMI"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0055">Arginine biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000123233" description="N-acetyl-gamma-glutamyl-phosphate reductase">
        <location>
            <begin position="1"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00150"/>
        </source>
    </evidence>
    <sequence length="364" mass="38133" checksum="6F97295B5BFF6FCC" modified="2009-03-03" version="1">MTKYTVAVAGATGYAGGEALRILAAHPAFEVTAVAGHSSIGHRLGEYQPHIPQLADLIVEDTTPAVLDGHDVIVLALPHGASGALAAQLDDDAVVVDLGADHRLERQQAWDDYYGGDFYQHWTYGMPELILGIGSDGKYVRQRDELTGAKRIAGPGCNVTATTLALQPAIAQGLVDTKSIVADLAVGYSGAGKNLKRTNLLASEAMGSASPYSVGGTHRHIPEIRQNFAHAAGLGASQADMFSLAFTPILVPMSRGILASVSAKLTDEALALTDEQIHDIWVQAYEGQEFIFVLDPGVMPATQNVLGSNAAHVQVAVDRRSGTLHAFTAIDNLNRGTAGQAIESLNIAFGLNDATGLSKIGVAP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU56</accession>
    <name>ARGB_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetylglutamate kinase</fullName>
            <ecNumber evidence="1">2.7.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N-acetyl-L-glutamate 5-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NAG kinase</fullName>
            <shortName evidence="1">NAGK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argB</name>
        <name type="ordered locus">BLA_1247</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetylglutamate kinase family. ArgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DU56"/>
    <dbReference type="SMR" id="B8DU56"/>
    <dbReference type="STRING" id="442563.BLA_1247"/>
    <dbReference type="EnsemblBacteria" id="ACL29535">
        <property type="protein sequence ID" value="ACL29535"/>
        <property type="gene ID" value="BLA_1247"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1247"/>
    <dbReference type="HOGENOM" id="CLU_053680_0_1_11"/>
    <dbReference type="OMA" id="EGLYEDW"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04250">
        <property type="entry name" value="AAK_NAGK-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00082">
        <property type="entry name" value="ArgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037528">
        <property type="entry name" value="ArgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041727">
        <property type="entry name" value="NAGK-C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000728">
        <property type="entry name" value="NAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0055">Arginine biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000118337" description="Acetylglutamate kinase">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="67"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00082"/>
        </source>
    </evidence>
    <sequence length="305" mass="32315" checksum="8E473085750EC8E2" modified="2009-03-03" version="1">MHTDLGPDQKAEVLIEALPWLEEFFGKTIVIKYGGNAMVNDHLKECFAEDMVFLRQVGIHPVVVHGGGPQISQMLKALGIHSEFKGGLRVTTPEAMDVVRMVLTGKVSRELVGLINAHGPLAVGLSGEDAALFSASQRKPIIDGEPTDIGLVGDVVGVDASAVVDLIHAGRIPVVSSVAPNEDDATEVLNVNADSAAAALASALGAHKLVILTDVDGLYADWPDKNSLVGRIGVEDLRDLLPELESGMRPKMEACVRAIDGGVQQAHIIDGRKPHSILNEIFTTAGVGTMVEPGEGMELRSSYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU82</accession>
    <name>B8DU82_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218045.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1274"/>
    <dbReference type="EnsemblBacteria" id="ACL29561">
        <property type="protein sequence ID" value="ACL29561"/>
        <property type="gene ID" value="BLA_1274"/>
    </dbReference>
    <dbReference type="GeneID" id="66533099"/>
    <dbReference type="KEGG" id="bla:BLA_1274"/>
    <dbReference type="HOGENOM" id="CLU_033323_9_5_11"/>
    <dbReference type="OMA" id="TRHGKTE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="274" mass="31339" checksum="AF2DF42046C8DEAD" modified="2009-03-03" version="1">MIDEVMFMRHGRTAFNLQRRLQGQIDIPLDIVGQWQVDMSGFTLAQRFYWAKVSNIARHPDRLSQPSDPPIRRSDITEYEQAPASRRRMVVVSSDLFRAQQTAHAFADPLGLDVTLDSRLRERDFGQWEGMSREEINERYPEGYASWKAHEGGEAAYGVESRPDLGKRGSSTIRSYCDDPQYMDEPTTLFVVSHGSWIAATIGNLMGLPDSQLDNLTGMRNAFWSRMEPQYTSNSVLFHLTEYDKGPDVADAVDWENGPAYLRNPDMPMWKPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU90</accession>
    <name>B8DU90_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M22, glycoprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218034.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1282"/>
    <dbReference type="EnsemblBacteria" id="ACL29569">
        <property type="protein sequence ID" value="ACL29569"/>
        <property type="gene ID" value="BLA_1282"/>
    </dbReference>
    <dbReference type="GeneID" id="66533107"/>
    <dbReference type="KEGG" id="bla:BLA_1282"/>
    <dbReference type="HOGENOM" id="CLU_064886_3_3_11"/>
    <dbReference type="OMA" id="TASIYCA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022496">
        <property type="entry name" value="T6A_TsaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF11">
        <property type="entry name" value="PTHR11735:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03725">
        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TsaD" evidence="1">
        <location>
            <begin position="25"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="280" mass="30114" checksum="6D64F3A1B6499954" modified="2009-03-03" version="1">MNTLVIDTSFGSTVGITGHEPICEQDSRTHVEKLQHDIAQVCAEAKIQPHDIERIVVGIGPAPFTGLRAGIVAAKAIAYATGAQLLGQDSLSGQAAMMQAAYNGDPNLLNTAIFGNWNTPANAGTALHLTLSVNDARRKQLYYTLLANTNADTKDERIQLDMNIGTPSNIAAKVSAAVATIQQRHPDQPVAVDIVGHGASKYEQIWSEQPWHGITLDHSLLDTGAWGVKTFAALAEHDTEADANPRPIEPLYLRRPDVSVPNPLKHVLNHEGAHRNEANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUB9</accession>
    <name>B8DUB9_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tryptophan synthase alpha chain</fullName>
            <ecNumber evidence="7">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">trpA</name>
        <name evidence="9" type="ordered locus">BLA_1311</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="7"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217992.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1311"/>
    <dbReference type="EnsemblBacteria" id="ACL29598">
        <property type="protein sequence ID" value="ACL29598"/>
        <property type="gene ID" value="BLA_1311"/>
    </dbReference>
    <dbReference type="GeneID" id="66533136"/>
    <dbReference type="KEGG" id="bla:BLA_1311"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1373"/>
    <dbReference type="HOGENOM" id="CLU_016734_0_0_11"/>
    <dbReference type="OMA" id="LVMTYWN"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406">
        <property type="entry name" value="PTHR43406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL29598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="289" mass="30618" checksum="26C3C1857A8DA4F2" modified="2009-03-03" version="1">MTEYNTTPSGQPLGISHRPSPCRELFTRFKAQDKPAFIGYLPFGFPTMEQSLEAFATMVENGADIVEIGLPYSDPVMDGPVIQAASQIALNNGERIADVFKAVETVANAGGVPLIMSYWNLIYHYGVERFAADFANAGGAGLITPDLIPDEAGEWIEASDRHGLDRIFLVSPDSTDERLRVVCENARGFVYAASRMGVTGERSSLGTSPEDLVARTRKAGAENVCVGIGVSTAAQGKAVGQYADGVIVGSALVHTLLTEDGDARELTSGLAALAAKTAELAEGIHNARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUD0</accession>
    <name>B8DUD0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anaerobic C4-dicarboxylate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29609">
        <property type="protein sequence ID" value="ACL29609"/>
        <property type="gene ID" value="BLA_1322"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1322"/>
    <dbReference type="HOGENOM" id="CLU_143325_0_0_11"/>
    <dbReference type="OMA" id="CAVTVYC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="100" mass="11135" checksum="0E230D29482D3778" modified="2009-03-03" version="1">MVKPVSWAVIIGQLTTFVLFAMPYFLFLANKDSIGTHPRSLYERLGWPSAVVAVVLVFAELALMYVQARRAMRFEPAHVEPLPDDGDADGDETHEGMSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUD9</accession>
    <name>B8DUD9_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rluB</name>
        <name evidence="5" type="ordered locus">BLA_1333</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217967.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1333"/>
    <dbReference type="EnsemblBacteria" id="ACL29618">
        <property type="protein sequence ID" value="ACL29618"/>
        <property type="gene ID" value="BLA_1333"/>
    </dbReference>
    <dbReference type="GeneID" id="66533158"/>
    <dbReference type="KEGG" id="bla:BLA_1333"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1395"/>
    <dbReference type="HOGENOM" id="CLU_024979_1_2_11"/>
    <dbReference type="OMA" id="HVPKTYE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="19"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="257" mass="29275" checksum="C3256A30EF56A53F" modified="2009-03-03" version="1">MPHIYSQARKQYENDGDGIRLQKLLAQAGFGSRRKCEEMITDGRVEVDGELVTELGTRVDPKRQQVRVDGSRIRLNPRHITLALNKPRKVLSTMDDPKGRYTLRDIVGDKYERIFHMGRLDYDSEGLILMTNDGELSQHVMHPKYEVEKTYIATLEGHMSGTVCRRLVRTGVQLDDGWIKLDHCSIIDSNRDQTIVKVVLHSGRNRIVRRIFGAIGFPVKRLVRTQIGPIKLGDIKSGSYRVLSQDEVRALSKEVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUF3</accession>
    <name>B8DUF3_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Phosphatidylinositol phosphate synthase</fullName>
            <shortName evidence="10">PIP synthase</shortName>
            <ecNumber evidence="10">2.7.8.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">CDP-diacylglycerol--D-myo-inositol-3-phosphate 3-phosphatidyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BLA_1347</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the conjugation of the 1'-hydroxyl group of D-myo-inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid required for cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 10">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61216"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:85356"/>
            <dbReference type="ChEBI" id="CHEBI:144472"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Contains a di-nuclear catalytic Mg(2+) center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.-" evidence="10"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217950.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1347"/>
    <dbReference type="EnsemblBacteria" id="ACL29632">
        <property type="protein sequence ID" value="ACL29632"/>
        <property type="gene ID" value="BLA_1347"/>
    </dbReference>
    <dbReference type="GeneID" id="66533172"/>
    <dbReference type="KEGG" id="bla:BLA_1347"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1409"/>
    <dbReference type="HOGENOM" id="CLU_080384_0_1_11"/>
    <dbReference type="OMA" id="DGNMARQ"/>
    <dbReference type="UniPathway" id="UPA00220"/>
    <dbReference type="UniPathway" id="UPA00671"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02241">
        <property type="entry name" value="PIP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044268">
        <property type="entry name" value="PIP_synthase_PgsA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="CDP-DAG binding" evidence="10">
        <location>
            <begin position="28"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL29632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="223" mass="23986" checksum="E684D37EBE02B822" modified="2009-03-03" version="1">MLEKLRPWFKRLIAPIARALTRMGITANAVTVIGAVGTTIVGIASGITGWMFWGALVLTILVVFDSLDGSVAAITTGGTKFGAFLDSTLDRIADWAVLLGCIIYFFVRNSTFTAAHAGQRYDWICVSGMALAIYSVMTSFVTSYARARAQSVGYEAKNGVATRSDRLTIILVGMAICGLANNPLWLMIDMAVLALLGTITVFQRIREVYVSMRANGDAGVSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUF6</accession>
    <name>B8DUF6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217947.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1350"/>
    <dbReference type="EnsemblBacteria" id="ACL29635">
        <property type="protein sequence ID" value="ACL29635"/>
        <property type="gene ID" value="BLA_1350"/>
    </dbReference>
    <dbReference type="GeneID" id="66533176"/>
    <dbReference type="KEGG" id="bla:BLA_1350"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1412"/>
    <dbReference type="HOGENOM" id="CLU_013985_18_0_11"/>
    <dbReference type="OMA" id="QFFFVYF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="173" mass="19324" checksum="A645EA6B3A4824EE" modified="2009-03-03" version="1">MSEISIAENTQLQTIRDLSIATFRQTFAGTNTEEDMRDYIAHGLSPEVLGKELADPLQTFFVATVDGVPAGYMKVNLGTAQTERMPDDHAEVQRLYVLADFKRHGLGTRFMRTAEQFASAHGKQTLWLGVWEHNEPAKAFYRRMGFVETGAHTFVLGSDAQTDLIMKHALTAC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUJ6</accession>
    <name>PYRE_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="1">OPRT</shortName>
            <shortName evidence="1">OPRTase</shortName>
            <ecNumber evidence="1">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pyrE</name>
        <name type="ordered locus">BLA_1390</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217892.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DUJ6"/>
    <dbReference type="SMR" id="B8DUJ6"/>
    <dbReference type="STRING" id="442563.BLA_1390"/>
    <dbReference type="EnsemblBacteria" id="ACL29675">
        <property type="protein sequence ID" value="ACL29675"/>
        <property type="gene ID" value="BLA_1390"/>
    </dbReference>
    <dbReference type="GeneID" id="66533220"/>
    <dbReference type="KEGG" id="bla:BLA_1390"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1454"/>
    <dbReference type="HOGENOM" id="CLU_074878_0_1_11"/>
    <dbReference type="OMA" id="MKAYQRQ"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00103">
        <property type="entry name" value="PUR_PYR_PR_TRANSFER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000164671" description="Orotate phosphoribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="79"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="133"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <sequence length="231" mass="25110" checksum="4CC83111C9A5ED07" modified="2009-03-03" version="1">MTEALDTRFTQFLLESQALKFGSFTLKSGRQSPYFINAGAFDDGAKIATLGEFYAEKIQQEIAASNLAARIDTVFGPAYKGIPLAVATTIAMQHRFNASIGYTFDRKEKKDHGDGGTMVGKPLEDGMNVLLVDDVMTAGTAVREVVPKLKAQADVNIVGLVLSVDRMEKTKDSDLSAVQDVQREFGFPVFAIANVKEIFAAGRQLIGEHGQPYVTDEIAKAAEEYLTQYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUL2</accession>
    <name>B8DUL2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217875.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1406"/>
    <dbReference type="EnsemblBacteria" id="ACL29691">
        <property type="protein sequence ID" value="ACL29691"/>
        <property type="gene ID" value="BLA_1406"/>
    </dbReference>
    <dbReference type="GeneID" id="66533235"/>
    <dbReference type="KEGG" id="bla:BLA_1406"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1470"/>
    <dbReference type="HOGENOM" id="CLU_120940_0_0_11"/>
    <dbReference type="OMA" id="VIMWLPS"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="152" mass="17047" checksum="B2C43CA676A9A64E" modified="2009-03-03" version="1">MANRAQRRSKNNGGMPSQYDSTQGRGRSGMIDESQLQERSRRLKEGKKGPWKPSSSELEKYEEIALDTDPDNYDPPQVLRAPHSGRQWARLFSWIVIVVSAISFFVVMWVPNLPMWVIITVCAVFACGVISLFFTAGDSKNNPNLDQNGTAV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUL6</accession>
    <name>LEPA_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor 4</fullName>
            <shortName evidence="1">EF-4</shortName>
            <ecNumber evidence="1">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lepA</name>
        <name type="ordered locus">BLA_1410</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217869.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DUL6"/>
    <dbReference type="SMR" id="B8DUL6"/>
    <dbReference type="STRING" id="442563.BLA_1410"/>
    <dbReference type="EnsemblBacteria" id="ACL29695">
        <property type="protein sequence ID" value="ACL29695"/>
        <property type="gene ID" value="BLA_1410"/>
    </dbReference>
    <dbReference type="GeneID" id="66533239"/>
    <dbReference type="KEGG" id="bla:BLA_1410"/>
    <dbReference type="HOGENOM" id="CLU_009995_3_3_11"/>
    <dbReference type="OMA" id="MVQIAIQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000118037" description="Elongation factor 4">
        <location>
            <begin position="1"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="14"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="603"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="609"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="26"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="142"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="626" mass="69430" checksum="730FEA2D8A3A6AC8" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUM8</accession>
    <name>YBEY_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ybeY</name>
        <name type="ordered locus">BLA_1422</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217852.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DUM8"/>
    <dbReference type="SMR" id="B8DUM8"/>
    <dbReference type="STRING" id="442563.BLA_1422"/>
    <dbReference type="EnsemblBacteria" id="ACL29707">
        <property type="protein sequence ID" value="ACL29707"/>
        <property type="gene ID" value="BLA_1422"/>
    </dbReference>
    <dbReference type="GeneID" id="66533251"/>
    <dbReference type="KEGG" id="bla:BLA_1422"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1486"/>
    <dbReference type="HOGENOM" id="CLU_106710_3_2_11"/>
    <dbReference type="OMA" id="RMRIHPL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020549">
        <property type="entry name" value="YbeY_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46986">
        <property type="entry name" value="PTHR46986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01306">
        <property type="entry name" value="UPF0054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000199954" description="Endoribonuclease YbeY">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <sequence length="181" mass="20783" checksum="16022DCFB73DD480" modified="2009-03-03" version="1">MSVEVANETEWQLDPKVFSELGLWVMHQMRVSTQSELTITFVDPEPIAELHERWMDLQGPTDVMSFPMDELRPGDERNEPEGMLGDIVICPWVAQQQAQAAGHSTMEEMMLLTIHGVLHLLGYDHHTREQERQMFGLQRQLLLTFFALHHGTAWSATLPSGSVNELEVYERKYGTNRELGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUN0</accession>
    <name>B8DUN0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine triad (HIT) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pkcI</name>
        <name evidence="3" type="ordered locus">BLA_1424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217848.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1424"/>
    <dbReference type="EnsemblBacteria" id="ACL29709">
        <property type="protein sequence ID" value="ACL29709"/>
        <property type="gene ID" value="BLA_1424"/>
    </dbReference>
    <dbReference type="GeneID" id="66533253"/>
    <dbReference type="KEGG" id="bla:BLA_1424"/>
    <dbReference type="HOGENOM" id="CLU_056776_8_1_11"/>
    <dbReference type="OMA" id="SDCLFCK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="PTHR23089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="7"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="98"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="111" mass="12328" checksum="E727ACC20125090B" modified="2009-03-03" version="1">MKDADCLFCKIIDCEVPSEKVFEDAQVYAFKDINPKAKVHVLVVPRDHYRNVDALAQADPALLAHMVEVAQGIADDAYNGSYRLIFNTGEDAGQTVFHVHAHVLTGEPMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUN8</accession>
    <name>B8DUN8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FeS assembly ATPase SufC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sufC</name>
        <name evidence="6" type="ordered locus">BLA_1432</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Ycf16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217839.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1432"/>
    <dbReference type="EnsemblBacteria" id="ACL29717">
        <property type="protein sequence ID" value="ACL29717"/>
        <property type="gene ID" value="BLA_1432"/>
    </dbReference>
    <dbReference type="GeneID" id="66533262"/>
    <dbReference type="KEGG" id="bla:BLA_1432"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1496"/>
    <dbReference type="HOGENOM" id="CLU_000604_48_1_11"/>
    <dbReference type="OMA" id="MAMLEPK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
        <property type="entry name" value="ABC_FeS_Assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="259" mass="28272" checksum="C069EEB065B98EAC" modified="2009-03-03" version="1">MSTLEIRDLYASVETKEGRKQILRGVNLTVNSGETHAIMGPNGSGKSTLAYTLAGHPKYEVDSGEVLLDGEDILKMTPDERAKAGLFLAMQYPVEVPGVSMTNFLRTAVTEVTGKAPAIRTWAKELSSAMKDLKMDPKFASRSVNEGFSGGEKKRAEVLQLEMLKPKFAILDETDSGLDVDALRVVSEGVNHAKESNDFGILMVTHYTRILKYIKPDVVHVFAQGHFVKTGGPELADELEETGYDMYLPEGSDSESALA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUR2</accession>
    <name>RS4_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsD</name>
        <name type="ordered locus">BLA_1458</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217809.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DUR2"/>
    <dbReference type="SMR" id="B8DUR2"/>
    <dbReference type="STRING" id="442563.BLA_1458"/>
    <dbReference type="EnsemblBacteria" id="ACL29741">
        <property type="protein sequence ID" value="ACL29741"/>
        <property type="gene ID" value="BLA_1458"/>
    </dbReference>
    <dbReference type="GeneID" id="66533288"/>
    <dbReference type="KEGG" id="bla:BLA_1458"/>
    <dbReference type="HOGENOM" id="CLU_092403_0_3_11"/>
    <dbReference type="OMA" id="PVICDEQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000214280" description="30S ribosomal protein S4">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="S4 RNA-binding" evidence="1">
        <location>
            <begin position="93"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <sequence length="206" mass="23346" checksum="BA568CCFFD877876" modified="2009-03-03" version="1">MSNRSRRQVRLSRALGIALTPKAQRIFEKRPYAPGEHGRTRRRAESDYAVRLREKQRLRAQYGISEKQLRAAYEKGTHTAGQTGNAMLTDLETRLDALVLRAGIARTTAQARQFVVHRHILVDGNIVDRPSYRVKPGQTIQVKPKSQTMVPFQIAAEGTHRDVLPPVPGYLDVNLASLKATLTRKPEPEEIPVQVNIQYVVEFYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUR8</accession>
    <name>B8DUR8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1465"/>
    <dbReference type="EnsemblBacteria" id="ACL29747">
        <property type="protein sequence ID" value="ACL29747"/>
        <property type="gene ID" value="BLA_1465"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1465"/>
    <dbReference type="HOGENOM" id="CLU_808135_0_0_11"/>
    <dbReference type="OMA" id="VHRMQAI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="330" mass="36759" checksum="8910A4A52CD05877" modified="2009-03-03" version="1">MTKQHKGGADSPVSPDTQNPGSGTRAQDGLAAHAHNAAIRAQVHRMQAIAEEDDRFGYDRHATNRALSIANGVTVIILGFALGSFLQALPERNTADVQEVVKGLDRLIGLMTKELVELPHIQRHPESFIAEIVGILIGYTILKHAHEDSREYDAAFNRIEQFYTVSQRRRGWIRCGVLVVLGTVVILVTHGLLLAYGHGMGDGIAAGIAQTSIAAGVWCYVYGGLYATRTDLFLYNFRALRQVNVYELGKSESDARREMRLGEKRLCDLSSSLTNFTVAIGVLGALGLYFLPTFRSQYFWLPLVVMIGIALCMRWFVIRYARRRYEPDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUW1</accession>
    <name>B8DUW1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative amidophosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014482961.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1508"/>
    <dbReference type="EnsemblBacteria" id="ACL29790">
        <property type="protein sequence ID" value="ACL29790"/>
        <property type="gene ID" value="BLA_1508"/>
    </dbReference>
    <dbReference type="GeneID" id="66533340"/>
    <dbReference type="KEGG" id="bla:BLA_1508"/>
    <dbReference type="HOGENOM" id="CLU_054549_3_1_11"/>
    <dbReference type="OMA" id="PATRWCP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="145"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="255" mass="27783" checksum="D8B2EEE3F016A4EA" modified="2009-03-03" version="1">MGTSFVREWCAAAAGLLRELGYLLFPRGCAGCDAPDEVLCSRCESKFHHCIPFRLHPGTLHLGFACALYRGVAREAILNWKDHGDEECDGAFVTALNRLFDDLLAFCRQSGEQFPQAAVPNDILIVPAPSSASSLRRRGRSQLAPLAKALCSHANARGMQTTVAPLLIVRAHSKSVETNGADQRAQRARRTICINERATHDKEMDACRTVILIDDIVTTGATINRCATVLAEHGYTVFTALALAYTPSKHGYMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUX5</accession>
    <name>B8DUX5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar binding protein of ABC transporter system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">msmE</name>
        <name evidence="5" type="ordered locus">BLA_1522</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1522"/>
    <dbReference type="EnsemblBacteria" id="ACL29804">
        <property type="protein sequence ID" value="ACL29804"/>
        <property type="gene ID" value="BLA_1522"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1522"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1596"/>
    <dbReference type="HOGENOM" id="CLU_031285_12_3_11"/>
    <dbReference type="OMA" id="FQEWAKA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006061">
        <property type="entry name" value="SBP_1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01037">
        <property type="entry name" value="SBP_BACTERIAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867556" evidence="4">
        <location>
            <begin position="33"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="431" mass="47710" checksum="4A41115B95155492" modified="2009-03-03" version="1">MKFATRMRRSAMRRMLRGIGAAVCALAVGVGAAGCGNSAGSGQVTLDFFQFKAEAADWFKQAAQEFEKENPDIRININNSANAQTDLRTRFVKDRVPDVITFNGDYSFGTFAASGVFHDFTDDPLVSELNEGMVNIAKNLVQTSDPAKKRLYGLPFAGNASGYIYNKDLFRKVGLDPDNPPQTWDEFIAMLKKFRDAGINPVQATLADAWTTQAPLASLAGTLVPESEYAALKSGDTTFKQIWTEPIEKEIELFKYADSEKGVTYQQGTQNFAKGTAAIIPLGTYAIPQITMVNKDIDLGFAQMPATNDASKQILTAGDDVILTMGANSRHKEQSMRFIRFLMSKKQLENYADAQSAITPLKETYFGNKALEPVRPFFESNRVADFCDHYIPSSINIGGYLQSAIMSGNVNQFIDSMQNEWNKVQARDFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUX6</accession>
    <name>B8DUX6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible NagC/XylR-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218963.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1523"/>
    <dbReference type="EnsemblBacteria" id="ACL29805">
        <property type="protein sequence ID" value="ACL29805"/>
        <property type="gene ID" value="BLA_1523"/>
    </dbReference>
    <dbReference type="GeneID" id="66533920"/>
    <dbReference type="KEGG" id="bla:BLA_1523"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1597"/>
    <dbReference type="HOGENOM" id="CLU_036604_13_4_11"/>
    <dbReference type="OMA" id="VANIAMP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="402" mass="43871" checksum="1222ADD6A6AC35FA" modified="2009-03-03" version="1">METNSDSLDFPRWFSRSDATHNVARGIMQYGPIARTPLAQIFNLSQGALSRITSDLIYDGVIEEMPAGSTQAGRLPQGFDLRESSERRGRPQTALRIREDSHAFVGVNIHDGAITVSEVNTMCRPIGSDITETVSNTAPQAVVEQITRMVRELVAASPDAPAPTALGLSLGGHVEDDRYVTFAPFLYWDSSVDLGGMLQRDTGIPTKVFNDLDSVLLHECWFGDAIGVPRFAVITMGAGVGYSISDHGDPIDNPDKSYGLAGHVLIDPEGPRCSSGHIGCSQCLTSDSIAEEYSGIMGRVTTFEEFSHDLRANRPQARRLAERTCYRLGVLVATVSNLAMPSRVLVSGESSFIAKKNREFIRKGIDAYRHSQAAPVEFSIPRFSWRLWSDSAAARAIATYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV07</accession>
    <name>B8DV07_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta sliding clamp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">dnaN</name>
        <name evidence="13" type="ordered locus">BLA_0002</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a ring-shaped head-to-tail homodimer around DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the beta sliding clamp family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219018.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0002"/>
    <dbReference type="EnsemblBacteria" id="ACL28308">
        <property type="protein sequence ID" value="ACL28308"/>
        <property type="gene ID" value="BLA_0002"/>
    </dbReference>
    <dbReference type="GeneID" id="66532375"/>
    <dbReference type="KEGG" id="bla:BLA_0002"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.2"/>
    <dbReference type="HOGENOM" id="CLU_038149_1_1_11"/>
    <dbReference type="OMA" id="YLIMPVR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000804">
        <property type="entry name" value="DNA_pol_III_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 9 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="10">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="11">
        <location>
            <begin position="126"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="12">
        <location>
            <begin position="256"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACL28308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="374" mass="40666" checksum="88AA4F4FE08BCEBE" modified="2009-03-03" version="1">MKVEVNTASFADAVAWTTSVIDARPANPILAGVKLEAADGTMQLSAFTYEISARDHIEAGVDESGTVVVLGKLLADISKVLPAEKTYLSANETTMTITSGPATFTLQLMPESEYPDLPQLPPQIGQVDAETFTQTVTQAAVAVAHDENRPVLTGVHMRFAGEEVTLSSTDRFRLGRASFRWTPDEADLDTAALVRGSHLVKIARSVDERANVVIYLDPANPKLIGIANAGRISTVQLIDGEFPAVDRLYADSYPIQAVIRKEDLLGAAKRVSLVAERNAPIRMVFTDQQLTLTAGGADEASAKETLQIDLDGEDITVAFNPSYLREGLSVISEPYIRMKMTTAVKPVEFNGQQDEDGEESMSYRYLLVPMRFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV21</accession>
    <name>B8DV21_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619602.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0017"/>
    <dbReference type="EnsemblBacteria" id="ACL28322">
        <property type="protein sequence ID" value="ACL28322"/>
        <property type="gene ID" value="BLA_0017"/>
    </dbReference>
    <dbReference type="GeneID" id="66532393"/>
    <dbReference type="KEGG" id="bla:BLA_0017"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.18"/>
    <dbReference type="HOGENOM" id="CLU_1060348_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025831">
        <property type="entry name" value="RecG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038475">
        <property type="entry name" value="RecG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13749">
        <property type="entry name" value="HATPase_c_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c_4" evidence="2">
        <location>
            <begin position="24"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="137"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="280" mass="30919" checksum="493C2A50F8C9372F" modified="2009-03-03" version="1">MVLREAIANAVVHREYDTLFRNDPVNIDVYSDRVEISSPGNLWGGKTLQNLTNGVSRCRNTTLMQLLQKTPLIRGDHDGSAVEGQGSGIQFMINRMKELSLAQPDFHPTFDRFRVILYRGGAEIAANQQWVRSHVGHDLPGRESSVLYTVRALGRASVYDIRDRLGYDSDDIRAILATLVESGLIRQVATDIYEPPETPAITNASDAPAPPAAAPSSRQAIIDTIPTFGTISARDIAEATGKSLQTVHRILRELVDEGVITAIGKKQSRLRTYTRKQTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV41</accession>
    <name>B8DV41_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219078.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28342">
        <property type="protein sequence ID" value="ACL28342"/>
        <property type="gene ID" value="BLA_0037"/>
    </dbReference>
    <dbReference type="GeneID" id="66532414"/>
    <dbReference type="KEGG" id="bla:BLA_0037"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.39"/>
    <dbReference type="HOGENOM" id="CLU_039613_28_0_11"/>
    <dbReference type="OMA" id="HEHTLAK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="296" mass="33805" checksum="2D8C83CBF0CCBEFB" modified="2009-03-03" version="1">MTELEALRELVAFREYGTLSAAADELRITQPTMTRTMRKLERELGVPLFDRRAKNRLSLTHTGELAAQEAEQLLDAYDRFVETVRNDANLHNEIVVGSVAPGPLHFLEQAGERNAKWESSITVRHSLIEPDAVLDDLLLRKETMIITDREVDDPRVESLYLGEEYLGVAIDNFNPLAQRTSVTFADLAGMDFVVAHDIGPWRAVIEEQIPGAHFLYQQDLSALEQISKYSAFPFFYSNLTRSLRMTDERFMPHTRTAVSIADPANRIDFYATFLGDNRRLALPIQQYLAQHRPREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-12-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV44</accession>
    <name>B8DV44_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0042</name>
        <name evidence="3" type="ordered locus">BLA_0614</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28345">
        <property type="protein sequence ID" value="ACL28345"/>
        <property type="gene ID" value="BLA_0042"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28907">
        <property type="protein sequence ID" value="ACL28907"/>
        <property type="gene ID" value="BLA_0614"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0042"/>
    <dbReference type="KEGG" id="bla:BLA_0614"/>
    <dbReference type="HOGENOM" id="CLU_041900_3_3_11"/>
    <dbReference type="OMA" id="HCRRTWR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_ISL3" evidence="1">
        <location>
            <begin position="174"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="443" mass="50246" checksum="EC6BA74393E97C97" modified="2009-03-03" version="1">MNEETRPEPEFSVFDPQRFLGLDEMGLRVLSWRRLGRPDGPGLRQIRCEPDSHDARWCPSCGAYARVRSSWLRTLAHVPYGDDAVHLPVRVRRYECVPCSRSWSDDLEAVGAGRGVLSVPAVMWALRRVCLDSMTVSACARLLHVAWAVVDRAVRERGMLLLEQADRFSSVRAIGVDEHVWRHGAFGDRYVTVIVDLTPRCDGRPARLLDMVPGRSAQVLREWMQARGGEFTRRVGVVAMDAFAGWKQAVESVVPHAVEVIDPFHVVQLAAARVTKVRCRLQRDATGRRGVKGDRLYDCRRALLTSDEYLGARGRARLMALFAIQANRDLMLAHDAYQRVIHAYRCDDRRRGERMMRELIDDLTGPGRYKGCRELASLGRVLKRRMRDILALFRHPRSSNGPTEAINGRLETLRGNAMGFANTTSYIQRCLIHSSQLKDILTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV82</accession>
    <name>B8DV82_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218377.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0080"/>
    <dbReference type="EnsemblBacteria" id="ACL28383">
        <property type="protein sequence ID" value="ACL28383"/>
        <property type="gene ID" value="BLA_0080"/>
    </dbReference>
    <dbReference type="GeneID" id="66532455"/>
    <dbReference type="KEGG" id="bla:BLA_0080"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.85"/>
    <dbReference type="HOGENOM" id="CLU_131367_0_0_11"/>
    <dbReference type="OMA" id="GQWIVED"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="108"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="181" mass="19659" checksum="0E82D55F102CDA77" modified="2009-03-03" version="1">MITELTFAVLKYAFLILLWLFVWFITRSLYRDVAAFSPRKSRARRRKEREVRKSNDALAVSASAQPLPVSAPTPSAAAPSDTAPTPTLLVIIDGPLAGTSVPLNSSVITLGRAASNTVVLDDEFVSSHHARVYPDPNTGVWAIEDLHSTNGTVVNQQRISAPTILGPRVPVRIGATTFELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV97</accession>
    <name>B8DV97_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protease HtpX homolog</fullName>
            <ecNumber evidence="12">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">htpX</name>
        <name evidence="14" type="ordered locus">BLA_0095</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AD011</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase M48B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="12"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218392.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0095"/>
    <dbReference type="EnsemblBacteria" id="ACL28398">
        <property type="protein sequence ID" value="ACL28398"/>
        <property type="gene ID" value="BLA_0095"/>
    </dbReference>
    <dbReference type="GeneID" id="66532472"/>
    <dbReference type="KEGG" id="bla:BLA_0095"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.101"/>
    <dbReference type="HOGENOM" id="CLU_042266_3_0_11"/>
    <dbReference type="OMA" id="AVCCTEG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00188">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022919">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 12 14" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="13">
        <location>
            <begin position="75"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACL28398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="323" mass="35087" checksum="89F68AA14EBC9F64" modified="2009-03-03" version="1">MTGKLHLHNHYNGLKTAVLFAIMWAIIMIIWWATGARTSTLGIYLAIGVGTSFISYWFSDKLAIASMHAQPVTEQQAPELYRIVRELSQRAGKPMPRIYIAPTETPNAFATGRNENHAAVCCTQGILRILDEREIRGVLGHELMHVYNRDIRTSAIAGAMATVLTYLGYSMMYIGNSSSSNRDRDNGAGLLGLIGILLSTVLAPIAASLIQMAISRTREYDADEDGSELTGDPLALASALRKISGGVDANPLPKTSTDTSTAAMMIESPFRGADVSRLFSTHPPTEDRIARLNQMAVDMGQIAPGAASPQVAGYAQYSQYRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVA5</accession>
    <name>B8DVA5_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">6-O-methylguanine-DNA methyltransferase</fullName>
            <shortName evidence="7">MGMT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BLA_0103</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 7">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MGMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="7"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218399.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0103"/>
    <dbReference type="EnsemblBacteria" id="ACL28406">
        <property type="protein sequence ID" value="ACL28406"/>
        <property type="gene ID" value="BLA_0103"/>
    </dbReference>
    <dbReference type="GeneID" id="66532478"/>
    <dbReference type="KEGG" id="bla:BLA_0103"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.107"/>
    <dbReference type="HOGENOM" id="CLU_000445_52_2_11"/>
    <dbReference type="OMA" id="QANRANE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00772">
        <property type="entry name" value="OGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023546">
        <property type="entry name" value="MGMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 7 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="8">
        <location>
            <begin position="75"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor" evidence="7">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL28406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="159" mass="17615" checksum="CF27646FDB64B743" modified="2009-03-03" version="1">MQGFATYASEYGPVRVDWQDDAVVRLRIIPQADYDADGAGETTGLTDETFRELEQYFAGELRRFTVPIAFASGTPFQQAVWRALLQIPYGETRTYAQIAEAVGHPKAVRAVGSANNRNPIPFIVPCHRVVGANGNLVGYAYGVEMKRSLLQMEMRTLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVC7</accession>
    <name>B8DVC7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Branched-chain amino acid transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_0125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218423.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0125"/>
    <dbReference type="EnsemblBacteria" id="ACL28428">
        <property type="protein sequence ID" value="ACL28428"/>
        <property type="gene ID" value="BLA_0125"/>
    </dbReference>
    <dbReference type="GeneID" id="66532500"/>
    <dbReference type="KEGG" id="bla:BLA_0125"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.131"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="YLGAHHD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="69"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="101"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="335" mass="36695" checksum="3B145DE45D01919E" modified="2009-03-03" version="1">MADTTDKTSETTAAGSTATVKEPFYDIAKWATKAPEGEKLISTAYGDKVTEDLRYVKNEPGVHKPDPILVADNVTRRFGGMTAVDVRHFEIERHGITALIGPNGAGKTTFFNLMTGFDTPNTGTWQFDGKDMAHVNPEKVARGGMVRTFQLTKVMSRLTVLDNMMLGAQSHPGEGMFRSLFPGAWKKQEKENREKAEALLDRFLLYKKKDDYAGALSGGQRKLLEMARALMCDPKLVMLDEPMAGVNPALKQSLLDHIISLREDGTTVLFVEHDINMVRHIADWVTVMAEGKIVAEGQPKTVMDDPAVVDAYLGAHANIDLGDDSVLEGLEGGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVD6</accession>
    <name>B8DVD6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sucrose symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">scrT</name>
        <name evidence="8" type="ordered locus">BLA_0134</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0134"/>
    <dbReference type="EnsemblBacteria" id="ACL28437">
        <property type="protein sequence ID" value="ACL28437"/>
        <property type="gene ID" value="BLA_0134"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0134"/>
    <dbReference type="HOGENOM" id="CLU_040011_0_0_11"/>
    <dbReference type="OMA" id="WSTGTAR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="114"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="517" mass="54172" checksum="CE6C45ED151E35C6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVF6</accession>
    <name>B8DVF6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0155"/>
    <dbReference type="EnsemblBacteria" id="ACL28457">
        <property type="protein sequence ID" value="ACL28457"/>
        <property type="gene ID" value="BLA_0155"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0155"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_21_11"/>
    <dbReference type="OMA" id="MEYQPTE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="25"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="163" mass="18182" checksum="5F1485E88D73605F" modified="2009-03-03" version="1">MVPTPTAKENILLPLQIAHRPIDMDWFDKVVSVVKLQNRLDHRPSQLSGGQQQRVACARAIMERPSVIFADEPTGNLDSRSSHEVFEFLRMCVREYGQTIVMVTHDPRAASFADRVLVLSDGSIVQDLDHPSYDDILAVFAQDDDPQNGPVEVESATARSAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVF9</accession>
    <name>B8DVF9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Probable permease protein of ABC transporter system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BLA_0158</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619650.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0158"/>
    <dbReference type="EnsemblBacteria" id="ACL28460">
        <property type="protein sequence ID" value="ACL28460"/>
        <property type="gene ID" value="BLA_0158"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0158"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.168"/>
    <dbReference type="HOGENOM" id="CLU_000604_84_7_11"/>
    <dbReference type="OMA" id="WGTYLVK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
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            <dbReference type="PROSITE" id="PS50893"/>
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    </evidence>
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            <dbReference type="EMBL" id="ACL28460.1"/>
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        </source>
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    <sequence length="615" mass="67526" checksum="75239683530C14DA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVG1</accession>
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        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
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                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
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        <lineage>
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            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
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                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
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                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">AD011</strain>
        </source>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        </location>
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        <source>
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    </evidence>
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        <source>
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            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="217" mass="23061" checksum="8201BDDCDDA1CB72" modified="2009-03-03" version="1">MHSISSASSASASAARAASSARARAPRPALGIPRHGLRRERTDGKITRAVLELILAKGIGAVSIEAVAKRSGVAKTTIYRRYANTDDLLRHLSVAVGEPLDFSGFDTTFDGLRGVLKCIVDCFDEELGLKAIGVVLSSSNDYLANLAERVVTPAQQRFADFIGRGVSSGAFRGDVSVPFLFQTVIGSMMAAKALSDSSHDTWAHDMASLLWPTLAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVG7</accession>
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        <submittedName>
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        <name evidence="2" type="ordered locus">BLA_0166</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
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                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="ACL28468"/>
        <property type="gene ID" value="BLA_0166"/>
    </dbReference>
    <dbReference type="GeneID" id="66532541"/>
    <dbReference type="KEGG" id="bla:BLA_0166"/>
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    <dbReference type="OMA" id="GTYYAMI"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Phage_infect_YhgE_C"/>
    </dbReference>
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        <property type="entry name" value="Phage_infect_YhgE_N"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="pip_yhgE_Nterm"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        <location>
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            <end position="599"/>
        </location>
    </feature>
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        <location>
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            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="697"/>
            <end position="721"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="ACL28468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="732" mass="78787" checksum="51E0E1D10B4373E3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVG8</accession>
    <name>B8DVG8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phage infection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0167</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218482.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0167"/>
    <dbReference type="EnsemblBacteria" id="ACL28469">
        <property type="protein sequence ID" value="ACL28469"/>
        <property type="gene ID" value="BLA_0167"/>
    </dbReference>
    <dbReference type="GeneID" id="66532542"/>
    <dbReference type="KEGG" id="bla:BLA_0167"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.176"/>
    <dbReference type="HOGENOM" id="CLU_004534_2_0_11"/>
    <dbReference type="OMA" id="EMSKNTT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017501">
        <property type="entry name" value="Phage_infect_YhgE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017500">
        <property type="entry name" value="Phage_infect_YhgE_N"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03062">
        <property type="entry name" value="pip_yhgE_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03061">
        <property type="entry name" value="pip_yhgE_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="564"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="596"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="623"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="684"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="767"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="797"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="861"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="861"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="904"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="922" mass="100328" checksum="727B8BD4F12D74E4" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVH0</accession>
    <name>B8DVH0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Possible ABC transporter permease for cobalt</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_0169</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0169"/>
    <dbReference type="EnsemblBacteria" id="ACL28471">
        <property type="protein sequence ID" value="ACL28471"/>
        <property type="gene ID" value="BLA_0169"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0169"/>
    <dbReference type="HOGENOM" id="CLU_076847_2_0_11"/>
    <dbReference type="OMA" id="SWITQPT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL28471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="235" mass="25223" checksum="8F5640EF73077D65" modified="2009-03-03" version="1">MPIRATRGVLHFDPRVKLAMLVVANMMMFLHVGPYAGMMGVLLFSLPMLCGGKIALGMGMLACYAMCLGVDWLAAAVADAAPWLHVPGALAAGGAMMLPCLIAGMSAFATTPPGELVAALRRLHLPDAVVIPAIVLLRFFPTIARDYRMIRCSMRLRGINVGGWAMLCHPMRSLEYVLVPLLMNAANAAHDLTVSALTKGLGRRRATSSSAMLHMQAIDWAMLALCCLPLIPWQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVH7</accession>
    <name>B8DVH7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable TetR-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0176</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218493.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0176"/>
    <dbReference type="EnsemblBacteria" id="ACL28478">
        <property type="protein sequence ID" value="ACL28478"/>
        <property type="gene ID" value="BLA_0176"/>
    </dbReference>
    <dbReference type="GeneID" id="66532552"/>
    <dbReference type="KEGG" id="bla:BLA_0176"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.186"/>
    <dbReference type="HOGENOM" id="CLU_069356_11_2_11"/>
    <dbReference type="OMA" id="HLVNLCW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="237" mass="26132" checksum="F297D719C0B66E95" modified="2009-03-03" version="1">MANASRMSSYQRREQLLRIGRSLFAAKGFEAVSVEEIAATAKVSKPIVYEHFGGKEGLYAVVVDREMRALNDTLVAALSAQDVHPRQIVERTALALLTYIEENAEGFQVLVRDSPSTDPSSSFSSLLGDVSMRVGEILSEWFKKQKLPTKGVPYYAQMLVGMTVFTGQYWADQRKVSKEQLAALIVNLAWNGLSRMKAKPELRFEGEKAKKAAQRAAENDGTEETRTESPSAPAPSA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVN0</accession>
    <name>LEUC_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-isopropylmalate dehydratase large subunit</fullName>
            <ecNumber evidence="1">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Alpha-IPM isomerase</fullName>
            <shortName evidence="1">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">leuC</name>
        <name type="ordered locus">BLA_0229</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218170.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DVN0"/>
    <dbReference type="SMR" id="B8DVN0"/>
    <dbReference type="STRING" id="442563.BLA_0229"/>
    <dbReference type="EnsemblBacteria" id="ACL28531">
        <property type="protein sequence ID" value="ACL28531"/>
        <property type="gene ID" value="BLA_0229"/>
    </dbReference>
    <dbReference type="GeneID" id="66532605"/>
    <dbReference type="KEGG" id="bla:BLA_0229"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.242"/>
    <dbReference type="HOGENOM" id="CLU_006714_3_4_11"/>
    <dbReference type="OMA" id="CNMSIEM"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0432">Leucine biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000149354" description="3-isopropylmalate dehydratase large subunit">
        <location>
            <begin position="1"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01026"/>
        </source>
    </evidence>
    <sequence length="467" mass="50324" checksum="17FCF8534C8EF384" modified="2009-03-03" version="1">MGMTLAEKVWADHLVRKGSDGAPDLLYIDLMLMHEVTSPQAFEGLRLAGRTPRHLDQLIATEDHNTPTVDIDKPNPDETSATQLTTLEKNCREFGVRLHPLGDADQGIVHAFAPMLGLTQPGMTIVCGDSHTSTHGAFGALAFGIGTSEVEHVMATQTLSLKPFKTMAINIEGDLPAGVSAKDIILAIIAKIGTGGGQGYVLEYRGRAIEQLSMDARMTICNMSIEAGARAGMIAPDETTFAYLKGRPHAPKGEMWDQAVEYWKTLRTDDDAVFDAEVTLRAEDLEPFVTWGTNPGQGVAISGVVPAPDDFADATERSAAERALDYMGLEPGTPIRDIPVDTVFIGSCTNGRIEDLRIAAEIMKGHKKADSIHRVLVVPASSRIRLQAEREGLDRIFKDFGAEWRNAGCSMCLGMNPDKLVAHERSISTSNRNFEGRQGKGSRTHLASPAVAAATAIRGTISTPADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVN3</accession>
    <name>B8DVN3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH oxidase</fullName>
            <ecNumber evidence="2">1.6.99.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nox</name>
        <name evidence="2" type="ordered locus">BLA_0232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.6.99.3" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268313.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="SMR" id="B8DVN3"/>
    <dbReference type="STRING" id="442563.BLA_0232"/>
    <dbReference type="EnsemblBacteria" id="ACL28534">
        <property type="protein sequence ID" value="ACL28534"/>
        <property type="gene ID" value="BLA_0232"/>
    </dbReference>
    <dbReference type="GeneID" id="66532608"/>
    <dbReference type="KEGG" id="bla:BLA_0232"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.245"/>
    <dbReference type="HOGENOM" id="CLU_003291_1_0_11"/>
    <dbReference type="OMA" id="DKNHTNY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="4"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="448" mass="48590" checksum="FDD484F87C1D9863" modified="2009-03-03" version="1">MTTTVAVVGCTHAGVFAANSILREHPDWQVHVFERNETVSFLSCGIALWVGGHVSDPKKMFYSSPQALEQAGATVHMHTDVTDVDVAAKTLEFRDLQTGDTQTLPYDKLVVTTGSRPIVPPLPGIDSKRVQLCKNWDDAVQIKERAHDLKNVIVIGAGYIGAELAEQFSTRGTQVTLIDAADRVLANNFDRFITDQVEAKYREHGVTLALGEAVKAFRDNGDSITVVTTKGEYTAPYAVLAVGFRPNTDLVRGQVETLDNGAIVVDEFMRASVPDVFAAGDSATVLFNPTGKLDYIPLATNAVRQGELVGLNIEKPTRKYMGTQATSAVQLYDLSLAASGMTQTYANNHGLDIRSTELLEDYRPAFMLSTAPVSCMLTWDPQTRLVKGAQFCSTTDEVAGAANVVSVAIQAKFTIDMLANVDFLFQPNFDQPVYYVGAVAAKAAAEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVN9</accession>
    <name>B8DVN9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative metal-dependent membrane protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0238"/>
    <dbReference type="MEROPS" id="G05.007"/>
    <dbReference type="EnsemblBacteria" id="ACL28540">
        <property type="protein sequence ID" value="ACL28540"/>
        <property type="gene ID" value="BLA_0238"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0238"/>
    <dbReference type="HOGENOM" id="CLU_053096_0_0_11"/>
    <dbReference type="OMA" id="GGMGIMM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="323" mass="35361" checksum="7A3FED1637062C79" modified="2009-03-03" version="1">MGERNAVESARRSYSRIGASFSVMIVVWMALVFVLGIGISMLHREAAHWMWVSLLVSDCSFYLVAVPLAYLMLRSVPEEPTRKFGMTFGELFEWFLVSLAIVFVGGLLGNALAALFSGGMAQNRLDNIVGGIPAWLNILAVVVVGPIVEEWLCRKQIIARVRRYGERLAIVVSALVFALFHLNLYQFFYAFGLGLVLGYIYMRTSQLKYTIGLHMAINFLGSVVGPFFSDWSDAHSAALDAGDVSGPELVVGVAAMLYILLYLVAVVAGVVLLIVKCRRLEFYVTPAQLPKGTACSCAFVNAGMGVFITLTVFGMVLALMNVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVP2</accession>
    <name>B8DVP2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted hydrolases or acyltransferases (Alpha/beta hydrolase superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619676.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0241"/>
    <dbReference type="ESTHER" id="bifan-b2ea73">
        <property type="family name" value="Duf_2974"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28543">
        <property type="protein sequence ID" value="ACL28543"/>
        <property type="gene ID" value="BLA_0241"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0241"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.256"/>
    <dbReference type="HOGENOM" id="CLU_043142_2_0_11"/>
    <dbReference type="OMA" id="FNMAFRY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024499">
        <property type="entry name" value="Mbeg1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11187">
        <property type="entry name" value="DUF2974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="398" mass="45375" checksum="0FBA10834A40FC44" modified="2009-03-03" version="1">MATIIDYVAQETRDFSEYPFHVADALVYAILSYDKIPQEAPQLSSLLECFGSISSKLRNFNLKHPSRSLAALWRTPFPGPTLREVEERLHEYELTHPYWEHHSGFSDDDETPHRFYRSIKRNPRFAVTRMSAAEERFDISQQTQYAAETFQLPDGTLLVAFRGTDDSLTGWREDFNMAFTYPVPAQKQAADYLEKVGRLWPNARIMLTGHSKGGNIAIYAAMNARDQIKDRIERIYAFDSPGFNQDVVSSYEYGTIVDRITKLVPEFSIIGMLLQSSPREHMIVVKSNADGLMQHSCYTWLMDGDRFDTVPALSESSRDFRGALNTWLNGMTQRQREHGVEALFRVLSSGGHSTITQLRTDGMKALPGLFSSYVGLDSEDRHYINQAIMLLAGTRFTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVR3</accession>
    <name>B8DVR3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268376.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0262"/>
    <dbReference type="EnsemblBacteria" id="ACL28564">
        <property type="protein sequence ID" value="ACL28564"/>
        <property type="gene ID" value="BLA_0262"/>
    </dbReference>
    <dbReference type="GeneID" id="66532637"/>
    <dbReference type="KEGG" id="bla:BLA_0262"/>
    <dbReference type="HOGENOM" id="CLU_054974_3_0_11"/>
    <dbReference type="OMA" id="TSMLHWH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="PTHR42695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="245" mass="26694" checksum="C16720F9F2665F90" modified="2009-03-03" version="1">MTKPEVLILQHAEWEKPGLILSDLEEINLPTQTLNISKQKKPDLPDFDEVAGLVVMGGPMGAADFDDYPGLKAEMKLIRAAIGTGKPVLGVCLGHQLIGAALGARVKKASAPEIGIAPIKRVAKHDFFSMWSKELNVLQWHGDCISLPDSAELLARSSDTRVQAFRFGSALGMQFHLEVTPQLLEEWLDEPSMVKQLKASGGSKSQLREAFAASYPQIQPLGEQVFSGFAARCSTYSFSLTSRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVX2</accession>
    <name>B8DVX2_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="5">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BLA_0321</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="5"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268491.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0321"/>
    <dbReference type="EnsemblBacteria" id="ACL28623">
        <property type="protein sequence ID" value="ACL28623"/>
        <property type="gene ID" value="BLA_0321"/>
    </dbReference>
    <dbReference type="GeneID" id="66532700"/>
    <dbReference type="KEGG" id="bla:BLA_0321"/>
    <dbReference type="HOGENOM" id="CLU_030903_0_1_11"/>
    <dbReference type="OMA" id="VMENVAN"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DHAP_synth_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PTHR21225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_synth_1" evidence="6">
        <location>
            <begin position="63"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL28623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="376" mass="40966" checksum="A1278EB73A2E4749" modified="2009-03-03" version="1">MAAMRGPDSSQDSVLDANAVVPETVDVNIRQLDPIPAPRYFIKELPLTEQMGKQVLEQRAQIRDILHGRDDRMLAIVGPCSIHDPKAAHEYATRLAELADELKRDLLIVMRVYFQKPRTTIGWKGLINDPDIDGEFDIRKGMWLARKVLCDVVGMGLPAATEWLDPITPQYLCDLVSWGAIGARNTESQVHRELASGLSMPIGFKNATDGSVKPAADSCYTAAFEHHFLSINLDGHVIAAETKGNPDCHLVLRGSNHGPNYDAESVAAALRDLHESKAEGPSKHGLIIDAAHGNCGKNEVVEAAVVENIAERIAGGERGILGIMMESFLKGGHQAPAPLAQLEYGQSITDSCVPWARSEEVLRKLAQAVNARRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVX4</accession>
    <name>B8DVX4_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-deoxy-7-phosphoheptulonate synthase</fullName>
            <ecNumber evidence="5">2.5.1.54</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">3-deoxy-D-arabino-heptulosonate 7-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">DAHP synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phospho-2-keto-3-deoxyheptonate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BLA_0323</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="5"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0323"/>
    <dbReference type="EnsemblBacteria" id="ACL28625">
        <property type="protein sequence ID" value="ACL28625"/>
        <property type="gene ID" value="BLA_0323"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0323"/>
    <dbReference type="HOGENOM" id="CLU_030903_0_1_11"/>
    <dbReference type="OMA" id="DINTGLR"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DHAP_synth_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PTHR21225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_synth_1" evidence="9">
        <location>
            <begin position="102"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL28625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="415" mass="45231" checksum="D4614E20F560E314" modified="2009-03-03" version="1">MSENPYEPMSKEQKDAIVQGNGLTYTHEQMRQVQHAIAAGKNPLVVLENVPRWEDMAGVDRIINRRVLELDPLPTPAQVLAELPLTRQMQDIVAYSRDEVRACLYGQDDRLLVIVGPCSVHDPKAALDYAHRLRTLKDELGEDLLIVMRVYFEKPRTTVGWKGLINDPDIDGSHNIQKGLLLARRTLLDVLGAGVATATEFLEPTSPQYIADAVSWGAIGARNTESQVHRQLASGMSMPIGFKNATDGSVKAAVNSCIAAEDQHTFFGIDHRGRACAVETLGNPDCHVVLRGSSSGPNYDAESVAQALASIRDKMGDEAAASHGLVIDCSHGNSGKDDVRQAQVVREIAERIAGGERGISGVMMESFIVGGNQAPAPLAELTYGQSITDKCLSWPVTDELLHTLADAVRTRRWNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVZ5</accession>
    <name>B8DVZ5_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rpmG</name>
        <name evidence="5" type="ordered locus">BLA_0344</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0344"/>
    <dbReference type="EnsemblBacteria" id="ACL28646">
        <property type="protein sequence ID" value="ACL28646"/>
        <property type="gene ID" value="BLA_0344"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0344"/>
    <dbReference type="HOGENOM" id="CLU_190949_0_1_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018264">
        <property type="entry name" value="Ribosomal_L33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43168">
        <property type="entry name" value="PTHR43168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00582">
        <property type="entry name" value="RIBOSOMAL_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="43" mass="5169" checksum="809FCF71571C55C3" modified="2009-03-03" version="1">MACTVCKERNYITTKNRRNTPDRLELKKFCPKCGKQTLHRETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW25</accession>
    <name>B8DW25_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">rplE</name>
        <name evidence="9" type="ordered locus">BLA_0374</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268592.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0374"/>
    <dbReference type="EnsemblBacteria" id="ACL28676">
        <property type="protein sequence ID" value="ACL28676"/>
        <property type="gene ID" value="BLA_0374"/>
    </dbReference>
    <dbReference type="GeneID" id="66532757"/>
    <dbReference type="KEGG" id="bla:BLA_0374"/>
    <dbReference type="HOGENOM" id="CLU_061015_2_1_11"/>
    <dbReference type="OMA" id="ERMYAFL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_L5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_L5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="7">
        <location>
            <begin position="38"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="8">
        <location>
            <begin position="99"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL28676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="194" mass="22080" checksum="6C30ACE5674162C4" modified="2009-03-03" version="1">MSEVVDEVIIEEPVTPRLKTMYKEEILPELEKEFHHDNPMQIPRIEKVVVSMGVGAAARDSKLIEGAVRDLTAITGQKPKITKAKKSVAQFHLREGQAIGAYVTLRGDRMWEFLDRLLTLALPRIRDFRGINGHQFDGQGNYNFGLTEQSMFHEIDPDEIDHQRGMDITVVTTTKDDDEAYALLKLLGFPFKEN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW26</accession>
    <name>RS14Z_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsZ</name>
        <name evidence="1" type="synonym">rpsN</name>
        <name type="ordered locus">BLA_0375</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268593.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DW26"/>
    <dbReference type="SMR" id="B8DW26"/>
    <dbReference type="STRING" id="442563.BLA_0375"/>
    <dbReference type="EnsemblBacteria" id="ACL28677">
        <property type="protein sequence ID" value="ACL28677"/>
        <property type="gene ID" value="BLA_0375"/>
    </dbReference>
    <dbReference type="GeneID" id="66532758"/>
    <dbReference type="KEGG" id="bla:BLA_0375"/>
    <dbReference type="HOGENOM" id="CLU_139869_3_0_11"/>
    <dbReference type="OMA" id="RAYTRCN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_B">
        <property type="entry name" value="Ribosomal_S14_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023053">
        <property type="entry name" value="Ribosomal_S14_Z"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000166758" description="30S ribosomal protein S14 type Z">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <sequence length="61" mass="7082" checksum="F9A2FB505245555D" modified="2009-03-03" version="1">MAKTCLKVKALRKPKFKVRAYTRCMVCGRPHSVYRKFGLCRICLREKAHRGELPGVTKSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW36</accession>
    <name>B8DW36_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rpsM</name>
        <name evidence="8" type="ordered locus">BLA_0385</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0385"/>
    <dbReference type="EnsemblBacteria" id="ACL28687">
        <property type="protein sequence ID" value="ACL28687"/>
        <property type="gene ID" value="BLA_0385"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0385"/>
    <dbReference type="HOGENOM" id="CLU_103849_1_2_11"/>
    <dbReference type="OMA" id="YRGLRHK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="100"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="136" mass="15550" checksum="4EF1AE4725A0EBA4" modified="2009-03-03" version="1">MRDLRQTEGIAMARLAGVDIPNDKRIEVALTYIFGVGRTRAKETLEATGINPDTRVKDLTDEQLITLRDYLESNYKIEGDLRREVDADIRRKIQINSYQGMRHRKGLPVRGQRTKTNARTRKGPKRTVAGKKKATK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW39</accession>
    <name>RL17_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplQ</name>
        <name type="ordered locus">BLA_0388</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Contacts protein L32.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268620.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DW39"/>
    <dbReference type="SMR" id="B8DW39"/>
    <dbReference type="STRING" id="442563.BLA_0388"/>
    <dbReference type="EnsemblBacteria" id="ACL28690">
        <property type="protein sequence ID" value="ACL28690"/>
        <property type="gene ID" value="BLA_0388"/>
    </dbReference>
    <dbReference type="GeneID" id="66532771"/>
    <dbReference type="KEGG" id="bla:BLA_0388"/>
    <dbReference type="HOGENOM" id="CLU_074407_0_0_11"/>
    <dbReference type="OMA" id="YAVTELF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000184000" description="50S ribosomal protein L17">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01368"/>
        </source>
    </evidence>
    <sequence length="148" mass="16412" checksum="5EA5FF619593A020" modified="2009-03-03" version="1">MPTPKKGPRLASSPAHERLMLANMATSLFEHGRITTTLPKAKRLRPLAERLITFAKRGDLHSRRRVMRVIRNKSVVHKLFTQIAEQMEQREGGYTRIVKIAPRKGDSAPAAIIELVTEPVSPKKAVVKEAEAATKVAAKEEQTEAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW45</accession>
    <name>B8DW45_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="4">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="4">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">truB</name>
        <name evidence="7" type="ordered locus">BLA_0394</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="4"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268629.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0394"/>
    <dbReference type="EnsemblBacteria" id="ACL28696">
        <property type="protein sequence ID" value="ACL28696"/>
        <property type="gene ID" value="BLA_0394"/>
    </dbReference>
    <dbReference type="GeneID" id="66532778"/>
    <dbReference type="KEGG" id="bla:BLA_0394"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.422"/>
    <dbReference type="HOGENOM" id="CLU_032087_0_0_11"/>
    <dbReference type="OMA" id="HVETREY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02573">
        <property type="entry name" value="PseudoU_synth_EcTruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="PTHR13767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TruB_N" evidence="5">
        <location>
            <begin position="32"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="TruB_C_2" evidence="6">
        <location>
            <begin position="193"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL28696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="350" mass="37836" checksum="124D993C5866C482" modified="2009-03-03" version="1">MGTGKRDAKVNGVLIVDKPQGVTSHDIVAAVRAALHTRKVGHAGTLDPMATGALVIGVGHATRLLQYIVEHTKTYSATIRFGQRTTTDDADGEFVEREAEAAVLPTLEQVREAVANEYTGDIEQIPNAVSAIKVNGQRAYDLAREGRHVELKARRVTVHAFDVLGGRQTQAANGTPVLDVDVRVTCSAGTYIRALARDLGNDFHCGAHLTRLRREAVGAFRVRDARIVRAHAEARTFVNRDGEEITRNRAVLDCVGEDLAGHLLTMVQAAQLTLPVLAVSEAQAADLRFGRRIVAQAPTDDERPAHHHGEHVWAAIGSADGEPEVVAIVERAKHHEFKPVTVFAANTGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWD1</accession>
    <name>B8DWD1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619737.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28782">
        <property type="protein sequence ID" value="ACL28782"/>
        <property type="gene ID" value="BLA_0483"/>
    </dbReference>
    <dbReference type="GeneID" id="66532869"/>
    <dbReference type="KEGG" id="bla:BLA_0483"/>
    <dbReference type="HOGENOM" id="CLU_985769_0_0_11"/>
    <dbReference type="OMA" id="DSDIWAD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="301" mass="34281" checksum="7470AD71013D14F8" modified="2009-03-03" version="1">MADRQISEVLGDFLHRYRELYGIDADSFLRCAHSYGMNWGDRTLNVIEKGQATAGIRLTLVILCVLNQISDAKLRLADILDFTDPADSIRITPDISTPSRTLQRILRGRPVWFYGSPERPGNVDRAQREHEVRRSRDADNLTPPPPTCTEEQAMARLDVDLQTLRGWCNALFGMSLDETAHMRAQASADSTPELEAHAIVEEIYQDHVRKVKYSMRNCTTWSNSSINLMPTDELDRLEDDLSQMEDCLMKFMALRHISFVRDKRAYDADPRNTGPYAFQPDSDIWVDIDEPEDGTLGAEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWE8</accession>
    <name>B8DWE8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218197.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28799">
        <property type="protein sequence ID" value="ACL28799"/>
        <property type="gene ID" value="BLA_0500"/>
    </dbReference>
    <dbReference type="GeneID" id="61076258"/>
    <dbReference type="GeneID" id="66533631"/>
    <dbReference type="KEGG" id="bla:BLA_0500"/>
    <dbReference type="HOGENOM" id="CLU_2354146_0_0_11"/>
    <dbReference type="OMA" id="NANEWED"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="96" mass="10751" checksum="578EE9412BD0C000" modified="2009-03-03" version="1">MAEQQNIPDTNTHEGLGAVSADQVKQMEQIVSDTDHPYTDPITGKPNEDIPENEVGVSDASKEAKQDAAQREELAIDRPEETDNENQWEDPYLEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWF9</accession>
    <name>B8DWF9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28810">
        <property type="protein sequence ID" value="ACL28810"/>
        <property type="gene ID" value="BLA_0511"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0511"/>
    <dbReference type="HOGENOM" id="CLU_3022782_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="55" mass="6080" checksum="5AA5052B64EBF49A" modified="2009-03-03" version="1">MPAFGMGTHDMSAFHLGYFVICLHHQGVPSAPPQSTNAVFHGIFKYGRQPKTKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWI1</accession>
    <name>B8DWI1_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease J</fullName>
            <shortName evidence="9">RNase J</shortName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rnj</name>
        <name evidence="13" type="ordered locus">BLA_0533</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, may be a subunit of the RNA degradosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218247.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0533"/>
    <dbReference type="EnsemblBacteria" id="ACL28832">
        <property type="protein sequence ID" value="ACL28832"/>
        <property type="gene ID" value="BLA_0533"/>
    </dbReference>
    <dbReference type="GeneID" id="66533663"/>
    <dbReference type="KEGG" id="bla:BLA_0533"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.561"/>
    <dbReference type="HOGENOM" id="CLU_008727_3_1_11"/>
    <dbReference type="OMA" id="KNTCVFE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01491">
        <property type="entry name" value="RNase_J_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004613">
        <property type="entry name" value="RNase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030854">
        <property type="entry name" value="RNase_J_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041636">
        <property type="entry name" value="RNase_J_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17770">
        <property type="entry name" value="RNase_J_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004803">
        <property type="entry name" value="RnjA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00649">
        <property type="entry name" value="MG423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="12">
        <location>
            <begin position="92"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 10">
        <location>
            <begin position="435"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR004803-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACL28832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="635" mass="69768" checksum="17A718C27F28A2AD" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWJ0</accession>
    <name>B8DWJ0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative methanol dehydrogenase regulator-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">moxR</name>
        <name evidence="4" type="ordered locus">BLA_0542</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0542"/>
    <dbReference type="EnsemblBacteria" id="ACL28841">
        <property type="protein sequence ID" value="ACL28841"/>
        <property type="gene ID" value="BLA_0542"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0542"/>
    <dbReference type="HOGENOM" id="CLU_034716_2_0_11"/>
    <dbReference type="OMA" id="RAGQAMI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="2">
        <location>
            <begin position="172"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="3">
        <location>
            <begin position="365"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="459" mass="50270" checksum="F46F44E83189E4C4" modified="2009-03-03" version="1">MPHAPKSTRYRAFAGRPQPAQSPGTRHHDFRQGITVSSRIILQRRGSMTAKHEQPDAPHAQHTDEGYESTVLSRRGFHTPADVAPDSDATRLGGVHASPSRTEVQTVTETVSTVNMPTERDATAVRSESAHKGDIVRFHSLFDAIVANISQVVVDKEKTIRECVTALLAGGHVLLEDNPGTGKTQLARALAQSIDTSFKRIQFTPDLLPSDVVGVTFYDQKNGEFTFRPGPVFASIVLADEINRASPKTQSALLEVMEEQHVTVDGTTHTVPQPFMVIATQNPIEQLGTYSLPEAQMDRFLLRTTIGYPSRTRSMQLLKEADITDRASTIGSVVSAHDILDMRKAVQQVHIDDAIYEYILRLVEQTRNSELVAVGSSMRGALALTRCARVWAAADNRAYVIPDDVKDLAISVLAHRLTLTPDATFAGQSQHSAMQAIIDDVPVPQTGLNEAHESTHGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWK6</accession>
    <name>B8DWK6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyl transferase</fullName>
            <ecNumber evidence="3">2.4.1.83</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0558</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.83" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218287.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0558"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28857">
        <property type="protein sequence ID" value="ACL28857"/>
        <property type="gene ID" value="BLA_0558"/>
    </dbReference>
    <dbReference type="GeneID" id="66533688"/>
    <dbReference type="KEGG" id="bla:BLA_0558"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.588"/>
    <dbReference type="HOGENOM" id="CLU_033536_13_0_11"/>
    <dbReference type="OMA" id="TAYIHGF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="PTHR43398"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="11"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="102"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="343" mass="38888" checksum="17B4B25D628EB95D" modified="2009-03-03" version="1">MAQVNSGHRVCVVMPTYNERDNLEPTLTDLFLRNAGVDVLIVDDNSPDGTGTLADVISRVTRLPQDLNVEHNENDVLRDVSFADEDSDSSLYSDTQVSTQDLKIADRLASCTMDSRVFVLHRPGKQGLGTAYIQGFEWALGHRYDIVCEMDMDGSHRPQDLRAIIDVLERHPQVDLVLGSRRVPGGSTQDWPWYRDVISRAGSQYARVMLGLKVRDMTSGFRAYRSRILRQIDLDGIDANGYVFQIDMTRRVIAAGGHVVEVPIVFPDRTKGDSKMDGSIVREAMRKVTQWGFTRMQQTILHNNERMERQVEDDLELPGQLMREDAGLAQDDPEQSEEYMERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWL8</accession>
    <name>B8DWL8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Possible alpha beta hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.24" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218304.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0572"/>
    <dbReference type="EnsemblBacteria" id="ACL28869">
        <property type="protein sequence ID" value="ACL28869"/>
        <property type="gene ID" value="BLA_0572"/>
    </dbReference>
    <dbReference type="GeneID" id="66533700"/>
    <dbReference type="KEGG" id="bla:BLA_0572"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.603"/>
    <dbReference type="HOGENOM" id="CLU_020336_50_4_11"/>
    <dbReference type="OMA" id="ESYLMHD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047570">
        <property type="term" value="F:3-oxoadipate enol-lactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="25"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="308" mass="33059" checksum="D8474987C694CAF7" modified="2009-03-03" version="1">MADDHARELPVIANHVIREGNGIPLVLVHGFPVDSRMWGRCAMALMELSDADELVQYPIWAPDMPGAGESPVPTAAQSGRENEDGSLPDGLDRIADAYVALLNDAGYTQAIWAGLSMGGYVVLGIQRRHPQAVAGIALLDTKGDADSDQAHASRIAIAKECVERQTTEPVMFFVDVHEGDSSVKKSAAYIDQFSQWIREQQPDGVAWRERMAAARPDLNDEFAKITAPAAVICGEEDPSSAPAVMRPLAERMVNTTVVMTEIEDCGHFSAWERPETVARALHELVSRVPAAAGADPAAADAAIAAREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWN7</accession>
    <name>B8DWN7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rfbN</name>
        <name evidence="2" type="ordered locus">BLA_0591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218323.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28888">
        <property type="protein sequence ID" value="ACL28888"/>
        <property type="gene ID" value="BLA_0591"/>
    </dbReference>
    <dbReference type="GeneID" id="66533719"/>
    <dbReference type="KEGG" id="bla:BLA_0591"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.622"/>
    <dbReference type="HOGENOM" id="CLU_061778_0_1_11"/>
    <dbReference type="OMA" id="VFMTQDA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="294" mass="32823" checksum="70F8A304695E2452" modified="2009-03-03" version="1">MDGAISVIVPTLNAGRQIDTLLTRLEQQTRKPDEIIVVDSSSEDITQEMIKRHPEVKLIVIDRKNFNHGGTRDAMLRESTGDFVLFLTQDAMPSGNDYIAKIVAPFADDEVALVYGRQLPRKDARPAEALVRKYSYGDESMVITKADIPSLGIKAFHSTDVCAAYRRTAYLEVGGFETDVLTNEDMFIAARFLHAGWKIVYEANATVIHSHNFTFKQQYKRNYIQGVEIAKHKDILGDASLSGEGFSLVKYTLGGLLRQGHVIEAMRFTVDCGFRLIGNRNGQRAAAKSHGRKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWS7</accession>
    <name>ATPL_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-type ATPase subunit c</fullName>
            <shortName evidence="1">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpE</name>
        <name type="ordered locus">BLA_0635</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219171.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DWS7"/>
    <dbReference type="SMR" id="B8DWS7"/>
    <dbReference type="STRING" id="442563.BLA_0635"/>
    <dbReference type="EnsemblBacteria" id="ACL28928">
        <property type="protein sequence ID" value="ACL28928"/>
        <property type="gene ID" value="BLA_0635"/>
    </dbReference>
    <dbReference type="GeneID" id="66533766"/>
    <dbReference type="KEGG" id="bla:BLA_0635"/>
    <dbReference type="HOGENOM" id="CLU_148047_5_2_11"/>
    <dbReference type="OMA" id="NIATVGY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005953">
        <property type="entry name" value="ATP_synth_csu_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="PTHR10031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01260">
        <property type="entry name" value="ATP_synt_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0138">CF(0)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0446">Lipid-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000184336" description="ATP synthase subunit c">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <sequence length="76" mass="7831" checksum="24E2B90976262AAD" modified="2009-03-03" version="1">MDIVTLAEVAGNLNVVGYGLAAIGPGIGLGILIGKTIESTARQPELGGRLQTLMFLGLAFVEVLALLGFVAAFIFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSI6</accession>
    <name>B8DSI6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619802.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0672"/>
    <dbReference type="EnsemblBacteria" id="ACL28965">
        <property type="protein sequence ID" value="ACL28965"/>
        <property type="gene ID" value="BLA_0672"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0672"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.700"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="AMEHIGC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="261" mass="28275" checksum="78647B63A5C85A47" modified="2009-03-03" version="1">MLDAKYAPKSRSAYAYLCSLAYTNNISKSRVDEVMDLTGPASVKKAKAGRFSLGMSQRLAIAASLLGDPKNLVLDEPVNGLDAEGVKWVRDLCRNCAAEGRAVLLSSHLMSEVALTADNLVIIGEGRILQTTTVSDFVEEHSRDLLSVVTPDAERMQAMFANSPSVRITETTVEDGYPADSRAFRIEGADFAAVAHGFARSQIVAYRFTREQVSLEQAYMELTHAHAQYVSAPMTAAGAQIPQNMPMQNMPVQNMGNGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSM5</accession>
    <name>B8DSM5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218732.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29004">
        <property type="protein sequence ID" value="ACL29004"/>
        <property type="gene ID" value="BLA_0711"/>
    </dbReference>
    <dbReference type="GeneID" id="66533472"/>
    <dbReference type="KEGG" id="bla:BLA_0711"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.742"/>
    <dbReference type="HOGENOM" id="CLU_2491606_0_0_11"/>
    <dbReference type="OMA" id="MQYQTNA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="83" mass="9556" checksum="ED358419DB2D317F" modified="2009-03-03" version="1">MTLLWSSLFTIIVVGLALWVLYYIIRAAVSAGIKDAYAQMGFIREPDTKEDQLQRRREELQEERVQTIVNSEADRMSGKNGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSP7</accession>
    <name>B8DSP7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase</fullName>
            <ecNumber evidence="2">3.6.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.13" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218703.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0733"/>
    <dbReference type="EnsemblBacteria" id="ACL29026">
        <property type="protein sequence ID" value="ACL29026"/>
        <property type="gene ID" value="BLA_0733"/>
    </dbReference>
    <dbReference type="GeneID" id="66533494"/>
    <dbReference type="KEGG" id="bla:BLA_0733"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.764"/>
    <dbReference type="HOGENOM" id="CLU_037162_3_2_11"/>
    <dbReference type="OMA" id="NVRWFPE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045830">
        <property type="entry name" value="AraR_wHTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19368">
        <property type="entry name" value="AraR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="269" mass="29995" checksum="A7DE996010096238" modified="2009-03-03" version="1">MGYGNVSERRFAPPQIGVTSVILALESETHGHARRRLWLPLVQRTREPFKGMWALPGGRLQANRSLEESAFATLASTTDLHPTYLEQLYTFGDPMRSSNGIPMVSVCYWALLDHADLGTEPGTAGNAHNVRWFPVDDLPELAFDHTTIVEYALWRLRHRMDAPNVVRQLIAEPFTLGQLHDVVEAVLGEEIDLANFRRKMLASHTLEDTGEVAREGRRRPAALYHFADHAEEEGFAFFAEHVAGNPHGACEALQVNTPDDALSALMPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSR6</accession>
    <name>B8DSR6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pepP</name>
        <name evidence="5" type="ordered locus">BLA_0752</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218681.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0752"/>
    <dbReference type="MEROPS" id="M24.033"/>
    <dbReference type="EnsemblBacteria" id="ACL29045">
        <property type="protein sequence ID" value="ACL29045"/>
        <property type="gene ID" value="BLA_0752"/>
    </dbReference>
    <dbReference type="GeneID" id="66533513"/>
    <dbReference type="KEGG" id="bla:BLA_0752"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.784"/>
    <dbReference type="HOGENOM" id="CLU_017266_1_0_11"/>
    <dbReference type="OMA" id="GWADTEL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP_N" evidence="4">
        <location>
            <begin position="61"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="523" mass="58542" checksum="7A3842B7FB2D8485" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSR7</accession>
    <name>B8DSR7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Nudix hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0753</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218680.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0753"/>
    <dbReference type="EnsemblBacteria" id="ACL29046">
        <property type="protein sequence ID" value="ACL29046"/>
        <property type="gene ID" value="BLA_0753"/>
    </dbReference>
    <dbReference type="GeneID" id="66533514"/>
    <dbReference type="KEGG" id="bla:BLA_0753"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.785"/>
    <dbReference type="HOGENOM" id="CLU_037162_7_3_11"/>
    <dbReference type="OMA" id="GEQPAAC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="175" mass="19643" checksum="2B6A0A04EF47F50D" modified="2009-03-03" version="1">MPTPDFILELRERIGHMPLWLIGVTGYVRRDDGLVLLEQRTDNGKWTLVTGINEPGEEPADTVAREAKEETGVDVIVTDLVSVKSDRRMITYANGDQAQYMDHLFLCEVAPGGNGEPVVGDDESMRVGWFALDDLPEPLSDSTRERIAYVQRYLRHRAEGSARAQFAFDGVIEHL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSV1</accession>
    <name>NRDR_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcriptional repressor NrdR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nrdR</name>
        <name type="ordered locus">BLA_0788</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NrdR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DSV1"/>
    <dbReference type="SMR" id="B8DSV1"/>
    <dbReference type="STRING" id="442563.BLA_0788"/>
    <dbReference type="EnsemblBacteria" id="ACL29080">
        <property type="protein sequence ID" value="ACL29080"/>
        <property type="gene ID" value="BLA_0788"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0788"/>
    <dbReference type="HOGENOM" id="CLU_108412_1_0_11"/>
    <dbReference type="OMA" id="YRFTTYE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00440">
        <property type="entry name" value="NrdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003796">
        <property type="entry name" value="RNR_NrdR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30455">
        <property type="entry name" value="PTHR30455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00244">
        <property type="entry name" value="TIGR00244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_1000191781" description="Transcriptional repressor NrdR">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-cone" evidence="1">
        <location>
            <begin position="46"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="zinc finger region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00440"/>
        </source>
    </evidence>
    <sequence length="200" mass="22227" checksum="758ED3009C178CA2" modified="2009-03-03" version="1">MHCPFCQNPDTKVIDTRISDDGHSIRRRRECPNCGARFSTLETTMLLVKKRSGNVEQFDRNKVIAGVRKACQGRPIHEDDLKRLGQQVEEDLRARGVAQVPSDEVGKAILRPLKDLDEVAYLRFASVYQNFEDLEDFQHAIDALRDSDKMLVSACPAGQAETSISCGYQLSMTRVRIVPVMASSASMVTSSGHLVTSVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSV3</accession>
    <name>B8DSV3_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">LexA repressor</fullName>
            <ecNumber evidence="12">3.4.21.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 16" type="primary">lexA</name>
        <name evidence="16" type="ordered locus">BLA_0790</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of Ala-|-Gly bond in repressor LexA.</text>
            <dbReference type="EC" id="3.4.21.88"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12 13">Belongs to the peptidase S24 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.88" evidence="12"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218629.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0790"/>
    <dbReference type="MEROPS" id="S24.001"/>
    <dbReference type="EnsemblBacteria" id="ACL29082">
        <property type="protein sequence ID" value="ACL29082"/>
        <property type="gene ID" value="BLA_0790"/>
    </dbReference>
    <dbReference type="GeneID" id="66533552"/>
    <dbReference type="KEGG" id="bla:BLA_0790"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.823"/>
    <dbReference type="HOGENOM" id="CLU_066192_45_0_11"/>
    <dbReference type="OMA" id="HVWLLPH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00015">
        <property type="entry name" value="LexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006200">
        <property type="entry name" value="LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006199">
        <property type="entry name" value="LexA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006197">
        <property type="entry name" value="Peptidase_S24_LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01726">
        <property type="entry name" value="LexA_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00726">
        <property type="entry name" value="LEXASERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00498">
        <property type="entry name" value="lexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="4 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="11 12" id="KW-0742">SOS response</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="LexA_DNA_bind" evidence="15">
        <location>
            <begin position="17"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S24" evidence="14">
        <location>
            <begin position="113"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="12">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="12">
        <location>
            <begin position="120"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ACL29082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="231" mass="25066" checksum="ED4269C8166FC40B" modified="2009-03-03" version="1">MSNLDAPTPAGSRPSLESLTKRQLQVLDAIRKLLEEQGFAPSLREIGKAANLKSTSSVQHQLHALESKGFIRRDPNKGRAIELVETQDGTSGGNPIVPFDGMDLEPSDFLDVPLVGAIAAGQPITAEQHVEDVMRLPVRLTGTGNLFMLEVKGDSMIDAAICDGDFVVVREQHNAENGDIVAALLDDEATVKTFRQEHGHTWLIPHNPNYAPIDGTHAQIMGKVVTVLRKI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSV5</accession>
    <name>LDH_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-lactate dehydrogenase</fullName>
            <shortName evidence="1">L-LDH</shortName>
            <ecNumber evidence="1">1.1.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ldh</name>
        <name type="ordered locus">BLA_0792</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of lactate to pyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-lactate + NAD(+) = H(+) + NADH + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23444"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.27"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Allosterically activated by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. LDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.27" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619833.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DSV5"/>
    <dbReference type="SMR" id="B8DSV5"/>
    <dbReference type="STRING" id="442563.BLA_0792"/>
    <dbReference type="PRIDE" id="B8DSV5"/>
    <dbReference type="EnsemblBacteria" id="ACL29084">
        <property type="protein sequence ID" value="ACL29084"/>
        <property type="gene ID" value="BLA_0792"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0792"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.825"/>
    <dbReference type="HOGENOM" id="CLU_045401_1_1_11"/>
    <dbReference type="OMA" id="ASCAEYI"/>
    <dbReference type="UniPathway" id="UPA00554">
        <property type="reaction ID" value="UER00611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00488">
        <property type="entry name" value="Lactate_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011304">
        <property type="entry name" value="L-lactate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018177">
        <property type="entry name" value="L-lactate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01771">
        <property type="entry name" value="L-LDH-NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00064">
        <property type="entry name" value="L_LDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0021">Allosteric enzyme</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000190772" description="L-lactate dehydrogenase">
        <location>
            <begin position="1"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="85"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="124"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="154"/>
            <end position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>beta-D-fructose 1,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>beta-D-fructose 1,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine" evidence="1">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00488"/>
        </source>
    </evidence>
    <sequence length="320" mass="34136" checksum="8019137D37E5A266" modified="2009-03-03" version="1">MVNSPIKPTKLAIVGAGAVGSTLAFAAAERGIAREIALQDIAKERVEAEVLDMQHGSSFFPTVSIEGSDDPEVCRDADMVVITAGARQKPGQSRLDLAGATINIMKSIIPNMLKVAPNAIYMLITNPVDIVTHVAMKLSGLPASRMFGSGTNLDSARLRFLIAQQTGVNVKNVHAYIAGEHGDSEVPLWASATIGGVPMCDWQALPGHEPLDAEARERIHQEVKNAAYKIINGKGATNYAISMSGVDIIEAILKDSNRILPVSSLLSDFHGISDVCMSVPTLLNRNGVNSRINTPVSDRELAALKRSAETLRETAAQFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSY0</accession>
    <name>B8DSY0_BIFA0</name>
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        <submittedName>
            <fullName evidence="5">LacI-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_0817</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ACL29109">
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        <property type="gene ID" value="BLA_0817"/>
    </dbReference>
    <dbReference type="GeneID" id="66533579"/>
    <dbReference type="KEGG" id="bla:BLA_0817"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.851"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001761">
        <property type="entry name" value="Peripla_BP/Lac1_sug-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00532">
        <property type="entry name" value="Peripla_BP_1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF47413"/>
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    </dbReference>
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        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="352" mass="38721" checksum="511F5BA08C518896" modified="2009-03-03" version="1">MTTMKEIAQAAGVSVSSVSLVLNGRDSGRINPQLANRIRETAERMGYQPNVLARSLRTNRTYMIGFISVEVATTPYAGGMIQGAQDALSSLGYMLLTVNGDTEQALESEIRALKRYGVDGFLYSAMSNRVMTVPKSLAKFPLVLVDAAEETNRFPSIEPDEFRIGYDATTRLIEAGCSRIAYVGCAEPMVAQTGRLAGYRQALMDHGRGFDERLQCDVLNNGPALRAVEALFDTEQPNGFFCFNDARAWYVYETAARHGLAVGRDISVVGVDNHRVFAETLEPQLTTIELPHYEMGYWAANKLVSMIENRPLNEGDWPHTTAVMPLLDTPSPVKVHCTLIEKGSVRDTPTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT34</accession>
    <name>B8DT34_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative galactofuranosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ACL29163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
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    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29163">
        <property type="protein sequence ID" value="ACL29163"/>
        <property type="gene ID" value="BLA_0871"/>
    </dbReference>
    <dbReference type="GeneID" id="66533849"/>
    <dbReference type="KEGG" id="bla:BLA_0871"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.910"/>
    <dbReference type="HOGENOM" id="CLU_019973_1_0_11"/>
    <dbReference type="OMA" id="WWYCCIP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="160"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="648" mass="73412" checksum="3CD44A2E5BF514ED" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT35</accession>
    <name>B8DT35_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219230.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0872"/>
    <dbReference type="EnsemblBacteria" id="ACL29164">
        <property type="protein sequence ID" value="ACL29164"/>
        <property type="gene ID" value="BLA_0872"/>
    </dbReference>
    <dbReference type="GeneID" id="66533851"/>
    <dbReference type="KEGG" id="bla:BLA_0872"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.911"/>
    <dbReference type="HOGENOM" id="CLU_022171_0_0_11"/>
    <dbReference type="OMA" id="KRGLWVA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="589"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="614"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="645"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="695"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="743" mass="83438" checksum="494E68C28D3841B1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT49</accession>
    <name>B8DT49_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219291.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0886"/>
    <dbReference type="EnsemblBacteria" id="ACL29178">
        <property type="protein sequence ID" value="ACL29178"/>
        <property type="gene ID" value="BLA_0886"/>
    </dbReference>
    <dbReference type="GeneID" id="66533865"/>
    <dbReference type="KEGG" id="bla:BLA_0886"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.928"/>
    <dbReference type="HOGENOM" id="CLU_079319_1_1_11"/>
    <dbReference type="OMA" id="VISSSHY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="227" mass="25878" checksum="9923876DC72097DF" modified="2009-03-03" version="1">MNTTAVQEAVRAGNEVGYMVPLDLGPAYADPEPRVPRQPERPHNSHSIIHTKQLPGPLAMQRLLRLDALYELDEFHAVTAECAHTLYGRAMLMRDILPNRTTACGRTAAWVWVGGRLPQDYFEVLSSSHYRRLAFGRRIKAWQRQVDESQISTLNTLNLTTPLRTACDLAMYPKDDPHARDVQSIIGRLMEHYEFSLVDCEPILEECSHLRNLPQAREMLTQFESIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT80</accession>
    <name>B8DT80_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0062</name>
        <name evidence="3" type="ordered locus">BLA_0917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28365">
        <property type="protein sequence ID" value="ACL28365"/>
        <property type="gene ID" value="BLA_0062"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29209">
        <property type="protein sequence ID" value="ACL29209"/>
        <property type="gene ID" value="BLA_0917"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0062"/>
    <dbReference type="KEGG" id="bla:BLA_0917"/>
    <dbReference type="HOGENOM" id="CLU_041900_3_3_11"/>
    <dbReference type="OMA" id="DEDRWCR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_ISL3" evidence="1">
        <location>
            <begin position="174"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="443" mass="50274" checksum="B929A2ABC1EB4729" modified="2009-03-03" version="1">MNEETRPEPEFSVFDPQRFLGLDEMGLRVLSWRRLGRPDGPGLRQIRCEPDSHDARWCPSCGAYARVRSSWLRTLAHVPYGDDAVHLLVRVRRYECVPCSRSWSDDPEAVGAGRGVLSVPAVMWALRRVCLDSMTVSACARLLHVAWAVVDRAVRERGMLLLEQADRFSSVRAIGVDEHVWRHGAFGDRYVTVIVDLTPRCDGRPARLLDMVPGRSAQVLREWMQARGGEFTRRVGVVAMDAFAGWKQAVESVVPHAVEVIDPFHVVQLAAARVTRVRCRLQRDATGRRGVKGDRLYDCRRALLTSDEYLGARGRARLMALFAIQANRDLMLAHDAYQRVIHAYRCDDRRRGERMMRELIDDLTGPGRYKGCRELASLGRVLKRRMRDILALFRHPRSSNGPTEAINGRLETLRGNAMGFANTTSYIQRCLIHSSQLKDILTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT81</accession>
    <name>B8DT81_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RAMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0918"/>
    <dbReference type="EnsemblBacteria" id="ACL29210">
        <property type="protein sequence ID" value="ACL29210"/>
        <property type="gene ID" value="BLA_0918"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0918"/>
    <dbReference type="HOGENOM" id="CLU_1025516_0_0_11"/>
    <dbReference type="OMA" id="RRANKGI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040843">
        <property type="entry name" value="RAMA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18755">
        <property type="entry name" value="RAMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAMA" evidence="2">
        <location>
            <begin position="178"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="280" mass="31556" checksum="F6CB42E54909B9B4" modified="2009-03-03" version="1">MRRANKGIPLQRIAGFHVDGDEQRLAMLHLRGELSIDSNMKRLLLIRANEQLAGGRITRPRSLNAVPLIPVRIQSGSDFADWPAGQCDYWAERIGNYVLTQSTRKSMEGLDDFQTRRARILRSPSSRQFPLTRVIGELEKLTPQFLQLRQHQIVELIAQAWNINPGELGSLAEPQGQSDRTGTSAHRSRRTSKRVTVGEVVRAGLLTVGDRFVWNRPRKHEIWRITVTESGFRGEDGTEYATPTSAARAIGGSSASLNVWKRESDGRALSDIWKTYRTSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTA4</accession>
    <name>B8DTA4_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pknA</name>
        <name evidence="8" type="ordered locus">BLA_0941</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217604.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0941"/>
    <dbReference type="EnsemblBacteria" id="ACL29233">
        <property type="protein sequence ID" value="ACL29233"/>
        <property type="gene ID" value="BLA_0941"/>
    </dbReference>
    <dbReference type="GeneID" id="66533445"/>
    <dbReference type="KEGG" id="bla:BLA_0941"/>
    <dbReference type="HOGENOM" id="CLU_000288_135_2_11"/>
    <dbReference type="OMA" id="WYINSGQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="7">
        <location>
            <begin position="531"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="7">
        <location>
            <begin position="605"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="7">
        <location>
            <begin position="672"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="293"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="350"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="364"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="741" mass="80035" checksum="05245C17994F68C4" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTB5</accession>
    <name>B8DTB5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type I phosphodiesterase/nucleotide pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217615.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0954"/>
    <dbReference type="EnsemblBacteria" id="ACL29244">
        <property type="protein sequence ID" value="ACL29244"/>
        <property type="gene ID" value="BLA_0954"/>
    </dbReference>
    <dbReference type="GeneID" id="66533434"/>
    <dbReference type="KEGG" id="bla:BLA_0954"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.996"/>
    <dbReference type="HOGENOM" id="CLU_039939_0_0_11"/>
    <dbReference type="OMA" id="LMNQLRW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="425" mass="45781" checksum="92EEEBC2B10ED621" modified="2009-03-03" version="1">MSVDIPDSGTLLGFVPTAQYGDEIDADRPSDVPAGLGNAQQGARGGALHISAVLPALSAAIGTPVRTDVHVDAEGLRQRLGMPRAKSAIVVLVDGLGYWNLNMKLGYAPYMRSLMNEPLNQRPISTCSPSTTTAAMATFGTGTCPGLTGMAGYTQLNPRTGALSQLIQFRGAIHPEELQTEPTVFSLISDAGNRATSVGLTRFMASPLTRAALCGSDYIGHDDANKRVRIAADTAKEPGLTYLYMREIDKAGHAYGWHSDEWQVALERVDMRLGQLHRQVPKGTLIVVIADHGMATADQGDEARIDMALDPVLQQGVRLVGGEPRATMLYAQDGVDAESIAERWRARLGDRAWIRTKQQVIDCGLLGPMRPDVPEMLGDVFVYAARENTIVDTRSQTEGATRMPGVHGSQTMMEMDVPCLIDLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTB9</accession>
    <name>B8DTB9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable GTP pyrophosphokinase</fullName>
            <ecNumber evidence="7">2.7.6.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">relA</name>
        <name evidence="7" type="ordered locus">BLA_0958</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate</text>
            <dbReference type="Rhea" id="RHEA:22088"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:142410"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the relA/spoT family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.5" evidence="7"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619888.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0958"/>
    <dbReference type="EnsemblBacteria" id="ACL29248">
        <property type="protein sequence ID" value="ACL29248"/>
        <property type="gene ID" value="BLA_0958"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0958"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1000"/>
    <dbReference type="HOGENOM" id="CLU_012300_3_0_11"/>
    <dbReference type="OMA" id="DWISSPK"/>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008728">
        <property type="term" value="F:GTP diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01668">
        <property type="entry name" value="TGS_RSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004811">
        <property type="entry name" value="RelA/Spo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045600">
        <property type="entry name" value="RelA/SpoT_AH_RIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033655">
        <property type="entry name" value="TGS_RelA/SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19296">
        <property type="entry name" value="DUF5913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00691">
        <property type="entry name" value="spoT_relA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="5">
        <location>
            <begin position="67"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="6">
        <location>
            <begin position="420"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="4">
        <location>
            <begin position="686"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="777" mass="86576" checksum="3D41C7D86F821705" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTE3</accession>
    <name>B8DTE3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mg chelatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217653.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0982"/>
    <dbReference type="EnsemblBacteria" id="ACL29272">
        <property type="protein sequence ID" value="ACL29272"/>
        <property type="gene ID" value="BLA_0982"/>
    </dbReference>
    <dbReference type="GeneID" id="66533405"/>
    <dbReference type="KEGG" id="bla:BLA_0982"/>
    <dbReference type="HOGENOM" id="CLU_026145_1_0_11"/>
    <dbReference type="OMA" id="STNPCPC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004482">
        <property type="entry name" value="Mg_chelat-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025158">
        <property type="entry name" value="Mg_chelat-rel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039:SF7">
        <property type="entry name" value="PTHR32039:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13335">
        <property type="entry name" value="Mg_chelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00368">
        <property type="entry name" value="TIGR00368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="218"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="510" mass="55247" checksum="870D0ED032F669D4" modified="2009-03-03" version="1">MALGTALSVGLVGLKAFMIQLQAFISPGLPFFSIIGLPDASLSEARERVKSACTASGFKWPQTRVTVNMSPASMPKRGSSHDLAIAASVLSASEFIEPDALDNTVLLGELNLDGTVLPINGLLPIMLHMKEHGMNRVVVPRANRDEAELIDGLDVMYVSHLGELIELFGGRANYTVHEIHVDTRRRDLPEGNLLPVGDMNEVVGQHDAKEALKIAAAGGHHVLMTGPPGMGKTMLASRFPGILAPLNQQQQFEVASIRSLCGQLGTHGIDSMPPFEAPHHTASVASLVGGGTGLGEPGSVTRAHHGVLFLDEAPEFAPRVLQSLREPLEAGYVAVSRSRGTTIFPAQFQLIMAANPCPCGYGYGTGERCTCRERDRIRYFSRLSGPILDRVDMQLQVCPVSHIGSRQLPEGDSSERIRQQVIAARSMAVERFRSFGWTSNAQAAGSWLREHTPHRVLAVVNQALSSYQISLRGAYRVMKLSWTICDLDGRTSPNLDDVDRALSLRTTEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTF8</accession>
    <name>B8DTF8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase</fullName>
            <ecNumber evidence="2">3.1.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lipA</name>
        <name evidence="2" type="ordered locus">BLA_0997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.3" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217674.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0997"/>
    <dbReference type="EnsemblBacteria" id="ACL29287">
        <property type="protein sequence ID" value="ACL29287"/>
        <property type="gene ID" value="BLA_0997"/>
    </dbReference>
    <dbReference type="GeneID" id="66533390"/>
    <dbReference type="KEGG" id="bla:BLA_0997"/>
    <dbReference type="HOGENOM" id="CLU_012494_0_0_11"/>
    <dbReference type="OMA" id="MMAFFRE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="123"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="357" mass="39581" checksum="BDD842CAFFA30D1F" modified="2009-03-03" version="1">MELYRNNEIPPIEYTPGTSEFRDAVIGLARYWTAIAEDLHADEPGVQERTAAACLRFRKECAMFDYARALQWHDPQGVYVHTDIPYLPDGGYRDGEVRGHLLDVYIPRDAIVRGGNTLPVYIDIHGGGFTYGYKELNRNFNTHLADLGFGVFSLNYRPAPQTDLVGQLHDIQAALCWIGEHITQFPVSPDNIFITGDSAGACLSLLTLLIEHNDDAAHAFGIERASGIHLRGASLISGVYDITPSSPMRARLAETVGNEFFAGLDDATVFLDPADWLTQGIGIPPLFLVTSSDDFVQSETLALATSLARNGRDFELHDFKVPCTQTLGHVFPVGMTWLPESERVLHGIREFSYPLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTF9</accession>
    <name>B8DTF9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable purine or uracil permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pyrP</name>
        <name evidence="7" type="ordered locus">BLA_0998</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0998"/>
    <dbReference type="EnsemblBacteria" id="ACL29288">
        <property type="protein sequence ID" value="ACL29288"/>
        <property type="gene ID" value="BLA_0998"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0998"/>
    <dbReference type="HOGENOM" id="CLU_017959_1_1_11"/>
    <dbReference type="OMA" id="INHGIGM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="446" mass="47249" checksum="AA5101AD156D8DB7" modified="2009-03-03" version="1">MKQMFTWTLHGNGKTLKPGEIVEPKERLTWPRTIGIGAQHVVAMFGATFLVPILTGFDPSTTLFFTAFSTALFLLINKNLLPSYLGSSFGFIAPIAAVASSGKGIAVASFGILCTGLLLAIIGFVVQWAGAIWIDRIMPPVVNGAIVAIIGFNLAPNVWTNFKAAPDTALVTLAAVLLIAVLFKGLIGRLNILLGVLVGYAYACIRGQVDFQAIEQAAWVGFPKFHLPQADFTILPMFLPVVLVLIAENVGHVKSVAQMTGHNYDDQIGTALIADGLGTTVAGIGGGSGTTTYGENIGVMAATKVYSTAAYWCAAGFAFLLSLCPKFGQVVNSIPVGVLGGVTCLLYGMIGMIGVQIWVDNKVDFAKPINIMTASVVMIVGIANFEFNVNGIQFNGIAIGSIIVLVLYHGMKAIGRATGTIVKEAPEPTPQERKFENLDEPIDPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTJ2</accession>
    <name>B8DTJ2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible exopolyphosphatase-like protein</fullName>
            <ecNumber evidence="2">3.6.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.11" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217718.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1033"/>
    <dbReference type="EnsemblBacteria" id="ACL29321">
        <property type="protein sequence ID" value="ACL29321"/>
        <property type="gene ID" value="BLA_1033"/>
    </dbReference>
    <dbReference type="GeneID" id="66533356"/>
    <dbReference type="KEGG" id="bla:BLA_1033"/>
    <dbReference type="HOGENOM" id="CLU_025908_1_2_11"/>
    <dbReference type="OMA" id="IGCVRMT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="1">
        <location>
            <begin position="20"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="340" mass="36983" checksum="480C21261EE42D9E" modified="2009-03-03" version="1">MTAVTVAGIDCGTNSIRLKIARVDEHGVTDVVPRMLRVVRLGQGVDETHRFSDEALERTYAAVREFKDVLDEHAVDAIRFVATSATRDADNREEFENTVESILGVRPEVISGTEEADLSFLAASSAISSLPDVEAPYLVVDLGGGSCELVLGGDGDTLPATKVQAAFSMNIGSVRMTERHLHHDPPTEQEIDEAVHDIDRHITEAFRHVPAGRTHTIVGVSGTVTTMTALAMGLTEYNHVAVDGVRMDFETAFAVDDRFLNMTRAERATHKTIHPGRIDVVGGGALVWNRVLARVAEAALLDHGQHIDSYVASEHGLLDGLIIDLGRRTLETCNERPTEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTM9</accession>
    <name>B8DTM9_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">map</name>
        <name evidence="5" type="ordered locus">BLA_1070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218766.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1070"/>
    <dbReference type="EnsemblBacteria" id="ACL29358">
        <property type="protein sequence ID" value="ACL29358"/>
        <property type="gene ID" value="BLA_1070"/>
    </dbReference>
    <dbReference type="GeneID" id="66532897"/>
    <dbReference type="KEGG" id="bla:BLA_1070"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1119"/>
    <dbReference type="HOGENOM" id="CLU_015857_0_1_11"/>
    <dbReference type="OMA" id="RGAESCY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="11"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="267" mass="29059" checksum="C03DFA683A0BBCF2" modified="2009-03-03" version="1">MIELKTPQEIEEMKPAGHFVGSILNELREKTKVGTNLLEIDEIVHKRIADRKGAQSCYVDYAPDFGTGPFAHYICISINDAVLHGVPYDYTLKDGDLVSLDLAISVDGWVGDSAISFVVGKDKDPSDLRLIKSTEEALAAGIAEAIPGNRLGDISHAIGEVAAEYGYPVNLEFGGHGVGHIMHGDPHVPNDGKAHHGYKLRPGLVIAIEPWFMKTTDEIFQDQRDGWTLRSVDGSRGAHSEHTIAITENGPIVLTAREGDPLSKLYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTN7</accession>
    <name>B8DTN7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glucan-binding protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_1078</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1078"/>
    <dbReference type="EnsemblBacteria" id="ACL29366">
        <property type="protein sequence ID" value="ACL29366"/>
        <property type="gene ID" value="BLA_1078"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1078"/>
    <dbReference type="HOGENOM" id="CLU_050983_0_0_11"/>
    <dbReference type="OMA" id="NSMQSRD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50911">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870879" evidence="3">
        <location>
            <begin position="28"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C51" evidence="4">
        <location>
            <begin position="338"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="464" mass="49200" checksum="D19EDC9F16C83EAA" modified="2009-03-03" version="1">MASSLASVLCIGALAVPMSTYTPQAYADTYSDLVNAQNSHAQSKQREAALREQLAGVNSDLADKIVELDDLNNNKIPAAQAKVQQANSDAAAAKSEADAAAERLKAAEKDKADLEAKIKQTGEDYDDAHAAVAQSARESMHGSDTSDVMSVMTGSKDTKDFIKSMQSRDALARNEANAASDAAVDLNTSMNRADRLKAIEKRVEQCKNDADQKSAAAQSAATQAQQEKSSLDKLRAAGESTRADLENQKSSLTTQAAQQAAQTVMLQSEIDAKNQQWAAEQAAAAAQVQEPEPQGTVEAPAAAAPQPSVPQQTQTPSQPAQTQRPSTPSQPSTPPTPVVTRPSTGGQGTSNGDYGNAYAAGQCTWWAYERRKQMGIGTPSYLGNGGQWWSTAPSYGLRVDHSPQVGAALSFLPGQEGASSPWGHVAVVEQVNGNSILISESNVAGLYTITYRTLYNPGRFWYVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTS2</accession>
    <name>B8DTS2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Predicted steroid reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BLA_1113</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218827.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1113"/>
    <dbReference type="EnsemblBacteria" id="ACL29401">
        <property type="protein sequence ID" value="ACL29401"/>
        <property type="gene ID" value="BLA_1113"/>
    </dbReference>
    <dbReference type="GeneID" id="66532936"/>
    <dbReference type="KEGG" id="bla:BLA_1113"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1166"/>
    <dbReference type="HOGENOM" id="CLU_072711_0_0_11"/>
    <dbReference type="OMA" id="GIWTGIW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="DUF1295"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="PTHR32251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="S5A_REDUCTASE" evidence="6">
        <location>
            <begin position="162"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="265" mass="29438" checksum="3BEA1FBF5A7B4EE5" modified="2009-03-03" version="1">MTFLIIFLVALAVSAVGFHRYIWFISIGYGFSIAAIGTALLIMFGVRHELTAVTAIMAALLVVYGLRLGGYLLAREYRSSSYHKVMQQAIDNGNNVKLPLRLLTWVGCALLYACEASPIAFRLQNHAGTDAVAIVGAAIMGVGIILESAADLTKNRFKQQHPHRFCDVGLFRMVRCPNYLGEIVTWTGVFVSGVTILDGAWQWIAAIGGYLCICWIMFGGARRLELRQNKEYADDPQYRHYSEHTPILIPFIPLHSLSNAKWLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTT0</accession>
    <name>B8DTT0_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="3 4">N5-CAIR mutase</shortName>
            <ecNumber evidence="3 4">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">purE</name>
        <name evidence="7" type="ordered locus">BLA_1121</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="3 4"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218839.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1121"/>
    <dbReference type="EnsemblBacteria" id="ACL29409">
        <property type="protein sequence ID" value="ACL29409"/>
        <property type="gene ID" value="BLA_1121"/>
    </dbReference>
    <dbReference type="GeneID" id="66532945"/>
    <dbReference type="KEGG" id="bla:BLA_1121"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1175"/>
    <dbReference type="HOGENOM" id="CLU_094982_2_2_11"/>
    <dbReference type="OMA" id="SNSIDGW"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 3 4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="6">
        <location>
            <begin position="6"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001338-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="165" mass="17460" checksum="8E9B80A0C83E65DF" modified="2009-03-03" version="1">MTANKPQVAVIMGSASDWETMRYACEMLDRFEVPYMKQVVSAHRTPELMGEFAHNARANGLKIIIAGAGGAAHLPGMVAAQTTLPVIGVPVRSHALSGWDSLLSIVQMPGGIPVATTAVGNSGATNAGLLAVSMLSMNDERLADALQAYRDELKEKVEQSNAELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTT4</accession>
    <name>B8DTT4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1125"/>
    <dbReference type="ESTHER" id="bifas-c6ahs7">
        <property type="family name" value="A85-Est-Putative"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29413">
        <property type="protein sequence ID" value="ACL29413"/>
        <property type="gene ID" value="BLA_1125"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1125"/>
    <dbReference type="HOGENOM" id="CLU_037947_2_0_11"/>
    <dbReference type="OMA" id="MMIGGEF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="422" mass="45686" checksum="05554255D407E177" modified="2009-03-03" version="1">MPEEGESRKRFLRQLGIGLLAGIVGLAATYVCSDVLLLFGVSLGWPVIIAIGVGVFLFAFMIAAAVMTHGWLRVLSIVMIPVTLLATAVRANAIYGEYQTMGSLFDYSPYPHISTLDLSLNTISVREWNEQAVAKSRNTTQIPQSGKLVHVDIPNPKSGFKAREALVWLPPAAFAKHPPKLPVMVMFAGQPGSPTRFFTASNAIEVLGRFAAEHHGLAPIVVSPDQNTAATRNSLCADTTKWGKAETYLAQDVPDWIKANLPVNDKASQWTIGGFSQGGTCATQLAPNHPNIYGNVLAVDGEVAPTEGSVDHMVEAYFSGDKAAYERQVPQNAIRNNAPSKQLMILGAGARDGESVDNIRKIGDTARENGWTVFRFAVSNWGHDWHAVNAVFAVALPYLCERMGLGNENVQFPTDSEVKEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTU9</accession>
    <name>B8DTU9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphoribosylformylglycinamidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_1140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218867.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1140"/>
    <dbReference type="EnsemblBacteria" id="ACL29428">
        <property type="protein sequence ID" value="ACL29428"/>
        <property type="gene ID" value="BLA_1140"/>
    </dbReference>
    <dbReference type="GeneID" id="66532964"/>
    <dbReference type="KEGG" id="bla:BLA_1140"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1196"/>
    <dbReference type="HOGENOM" id="CLU_003100_2_0_11"/>
    <dbReference type="OMA" id="LSANWMW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010141">
        <property type="entry name" value="FGAM_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01857">
        <property type="entry name" value="FGAM-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGAR-AT_linker" evidence="5">
        <location>
            <begin position="182"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="4">
        <location>
            <begin position="433"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="1244" mass="134460" checksum="DCF2C2C917704C38" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTV7</accession>
    <name>EFTU_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor Tu</fullName>
            <shortName evidence="2">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tuf</name>
        <name type="ordered locus">BLA_1148</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619946.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DTV7"/>
    <dbReference type="SMR" id="B8DTV7"/>
    <dbReference type="STRING" id="442563.BLA_1148"/>
    <dbReference type="EnsemblBacteria" id="ACL29436">
        <property type="protein sequence ID" value="ACL29436"/>
        <property type="gene ID" value="BLA_1148"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1148"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1205"/>
    <dbReference type="HOGENOM" id="CLU_007265_0_1_11"/>
    <dbReference type="OMA" id="EGDKEWG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000201387" description="Elongation factor Tu">
        <location>
            <begin position="1"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="10"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="1">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="1">
        <location>
            <begin position="62"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="1">
        <location>
            <begin position="83"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="1">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="1">
        <location>
            <begin position="175"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="83"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <sequence length="399" mass="44070" checksum="57F7BA8552E1B085" modified="2009-03-03" version="1">MAKEKYERTKPHVNIGTIGHVDHGKTTLTAAISKVLHDEYPDLNPEYDFNQIDAAPEEQQRGITINIAHIEYQTAKRHYAHVDCPGHADFVKNMITGAAQMDGAILVVAATDGPMAQTREHVLLAPQVGVPKILVALNKCDMVDDEELIELVEEEVRDLLDENGFDRDCPVVHTSAYGALHDDAPDHDKWVATIKELMDDVDEYIPTPVHDLDKPFLMPIEDVFTISGRGTVVTGRVERGKLPINTNVEIVGIRPTQTTTFTSIETFHKQMDECEAGDNTGLLLRGINRTDVERGQVVAAPGSVTPHTKFEGEVYVLTKDEGGRHSPFFSNYRPQFYFRTTDVTGVITLPEGVEMVQPGDHATFTVELIQPIAMEEGLTFAVREGGHTVGSGRVTKILA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTW0</accession>
    <name>EFP_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor P</fullName>
            <shortName evidence="1">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">efp</name>
        <name type="ordered locus">BLA_1151</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the elongation factor P family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218881.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DTW0"/>
    <dbReference type="SMR" id="B8DTW0"/>
    <dbReference type="STRING" id="442563.BLA_1151"/>
    <dbReference type="EnsemblBacteria" id="ACL29439">
        <property type="protein sequence ID" value="ACL29439"/>
        <property type="gene ID" value="BLA_1151"/>
    </dbReference>
    <dbReference type="GeneID" id="66532976"/>
    <dbReference type="KEGG" id="bla:BLA_1151"/>
    <dbReference type="HOGENOM" id="CLU_074944_0_1_11"/>
    <dbReference type="OMA" id="WSVVEFQ"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000122991" description="Elongation factor P">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <sequence length="187" mass="20517" checksum="EB255251E8216403" modified="2009-03-03" version="1">MAQTTNDIKNGSILNLDGQLWQVIKFQHVKPGKGPAFVRTTIKNVLSGKIVDKTFNAGMKMDFETVDNRTLQYSYEDGDNFVFMDMTTFDQIMIPKTLVGDKAKYLLEGTDCIVSFHDGQPLSVELPASVVLTITHTEPGLQGNRSNAGTKPATVETGAEIQVPLFIGEGEKVKVNTDDGSYLGREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTX0</accession>
    <name>B8DTX0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable primosomal protein N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_1161</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1161"/>
    <dbReference type="EnsemblBacteria" id="ACL29449">
        <property type="protein sequence ID" value="ACL29449"/>
        <property type="gene ID" value="BLA_1161"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1161"/>
    <dbReference type="HOGENOM" id="CLU_015485_1_0_11"/>
    <dbReference type="OMA" id="CTVEAAQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041222">
        <property type="entry name" value="PriA_3primeBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042115">
        <property type="entry name" value="PriA_3primeBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17764">
        <property type="entry name" value="PriA_3primeBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PriA_3primeBD" evidence="5">
        <location>
            <begin position="39"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="755" mass="81514" checksum="B59BAC758C16447D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU18</accession>
    <name>B8DU18_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29497">
        <property type="protein sequence ID" value="ACL29497"/>
        <property type="gene ID" value="BLA_1209"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1209"/>
    <dbReference type="HOGENOM" id="CLU_522414_0_0_11"/>
    <dbReference type="OMA" id="FEHYANM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045425">
        <property type="entry name" value="DUF6508"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20118">
        <property type="entry name" value="DUF6508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="326"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="547" mass="61908" checksum="955D765EB13D4D32" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU61</accession>
    <name>B8DU61_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Argininosuccinate lyase</fullName>
            <shortName evidence="5">ASAL</shortName>
            <ecNumber evidence="3 5">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">argH</name>
        <name evidence="8" type="ordered locus">BLA_1252</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="3 5"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218072.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1252"/>
    <dbReference type="EnsemblBacteria" id="ACL29540">
        <property type="protein sequence ID" value="ACL29540"/>
        <property type="gene ID" value="BLA_1252"/>
    </dbReference>
    <dbReference type="GeneID" id="66533074"/>
    <dbReference type="KEGG" id="bla:BLA_1252"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1315"/>
    <dbReference type="HOGENOM" id="CLU_027272_2_2_11"/>
    <dbReference type="OMA" id="KKNPDVF"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="6">
        <location>
            <begin position="28"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C2" evidence="7">
        <location>
            <begin position="376"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="498" mass="54723" checksum="935CCC39E2F417D6" modified="2009-03-03" version="1">MSDDHKPESQDHLALWGGRFSSGPSPELALLSKSTQFDWRLADDDIAGSRAHARALGRAGLLTADELQRMEAALDELQRQVDSGEFTPIDDDEDEATALERGLLQIAGDELGGKLRAGRSRNDQIATLIRMWMRRHARVVANQLLNLADALIVQAKDAGHTVMPGRTHMQHAQPVLLAHQLIAHVWPLLRDVERLRDWDQRVDASPYGSGALAGNTLGLEPVAVARELGFTNVTENSIDGTASRDLVAEFSFVMAMAGVDISRLSEEIIIWNTQEFGFVKLDDAYSTGSSIMPQKKNPDIAELARGKAGRLIGDLTGLLATLKGLPTAYTRDLQEDKEAVFDQVDTLEVLLPAFTGMIRTMRFDEQRLEKEAPTGFALATDIAEWLVKNGVPFRHAHELSGACVKVAENRGVELWDLSDDDFIEIFRGFVEPDVAVEVREVLSTEGSVSARAGKGGTAPNRVREQIMSAKTLIEQLRSFFQVKSDGMAYKACGSLNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU80</accession>
    <name>B8DU80_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Possible phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218048.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1271"/>
    <dbReference type="EnsemblBacteria" id="ACL29559">
        <property type="protein sequence ID" value="ACL29559"/>
        <property type="gene ID" value="BLA_1271"/>
    </dbReference>
    <dbReference type="GeneID" id="66533094"/>
    <dbReference type="KEGG" id="bla:BLA_1271"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1334"/>
    <dbReference type="HOGENOM" id="CLU_033323_9_5_11"/>
    <dbReference type="OMA" id="WQVRQTA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="210" mass="24038" checksum="8B19EE5DAEAC254A" modified="2009-03-03" version="1">MQGSIDIPLDEVGLWQVNQSAQSLIKLYVLPDPSRHQLVVSSDLERSMQTAHAFADRLGSEVHADERLRERHFGEFEGRSGAYLQANFPQDFDSWCRGMGGEMNHGAESHEHAGVRSMEAMNDWAHECDDDTDLFVFSHGALIENALQVLFGIERRYPDFTLTSMCNAHWARLRRADIDMDSRWIMEDYNHGPALADTQYWERPDTLPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUD6</accession>
    <name>B8DUD6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1328"/>
    <dbReference type="EnsemblBacteria" id="ACL29615">
        <property type="protein sequence ID" value="ACL29615"/>
        <property type="gene ID" value="BLA_1328"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1328"/>
    <dbReference type="HOGENOM" id="CLU_155691_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="93" mass="10756" checksum="EF13F73E2D579949" modified="2009-03-03" version="1">MLAVLIAGIIYVIIHGLHALQSVQRTGEAVSERIALMSDTEGTRHPKERPIFTEPLEVAANRYTQAHTKVDKRKRARRERYARIWSRWASFND</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUD8</accession>
    <name>B8DUD8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable UTP-glucose-1-phosphate uridylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ugpA</name>
        <name evidence="4" type="ordered locus">BLA_1330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217969.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1330"/>
    <dbReference type="EnsemblBacteria" id="ACL29617">
        <property type="protein sequence ID" value="ACL29617"/>
        <property type="gene ID" value="BLA_1330"/>
    </dbReference>
    <dbReference type="GeneID" id="66533155"/>
    <dbReference type="KEGG" id="bla:BLA_1330"/>
    <dbReference type="HOGENOM" id="CLU_023632_1_0_11"/>
    <dbReference type="OMA" id="TNNLWAK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="entry name" value="PTHR43511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="475" mass="53923" checksum="FB0C2100FB95965A" modified="2009-03-03" version="1">MTDAFERTAEKMKAHGLSETAIAQFEHLYDVWQHEDGTTWIREEDIEPVQDIPNFAQIYETINHDKAVDAFAKTAFLKLNGGLGTSMGLDCAKSLLPVRRHKAKQMRFIDIILGQVETARNRLGVELPLTFMNSFRTSADTMKVLNRDKRFHQDDIPMEIIQHVEPKIDLSTGEPVSFPSNPDLEWCPPGHGDLYSTLWESGLLDILESHGFKYLFISNSDNLGARPSRTLAQHFENTDAPFMIEVSKRTEADRKGGHIVRDKVTGRLMLREMTQVAPEDAAEAKNIDKHPYFNTNNIWVRIDSLREKLAQSNGVLPLPVIRNYKTVDPTDASTTEVIQLETAMGAAVSLFNGAICVEVDRMRFLPVKTTDDLFIMRSDRFHLTDQYEMEDGNYIFPNVQLDTRFYKNIHDFDDRFPYGVPSLAAAASVTVEGDWTFGRDVNFYGEATLHDEGRPSYVPNGEFVGPQGIEPDEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUE1</accession>
    <name>B8DUE1_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional purine biosynthesis protein PurH</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Phosphoribosylaminoimidazolecarboxamide formyltransferase</fullName>
                <ecNumber evidence="8">2.1.2.3</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">AICAR transformylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">IMP cyclohydrolase</fullName>
                <ecNumber evidence="8">3.5.4.10</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">ATIC</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">IMP synthase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">Inosinicase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">purH</name>
        <name evidence="10" type="ordered locus">BLA_1335</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The IMP cyclohydrolase activity resides in the N-terminal region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PurH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.3" evidence="8"/>
    <dbReference type="EC" id="3.5.4.10" evidence="8"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217965.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1335"/>
    <dbReference type="EnsemblBacteria" id="ACL29620">
        <property type="protein sequence ID" value="ACL29620"/>
        <property type="gene ID" value="BLA_1335"/>
    </dbReference>
    <dbReference type="GeneID" id="66533160"/>
    <dbReference type="KEGG" id="bla:BLA_1335"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1397"/>
    <dbReference type="HOGENOM" id="CLU_016316_5_2_11"/>
    <dbReference type="OMA" id="WRVAKFV"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL29620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="549" mass="59437" checksum="AB225412E1048574" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUG9</accession>
    <name>B8DUG9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase-like hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1363"/>
    <dbReference type="EnsemblBacteria" id="ACL29648">
        <property type="protein sequence ID" value="ACL29648"/>
        <property type="gene ID" value="BLA_1363"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1363"/>
    <dbReference type="HOGENOM" id="CLU_044146_0_3_11"/>
    <dbReference type="OMA" id="DEICPPN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="276" mass="30882" checksum="D86C341C4E96F57A" modified="2009-03-03" version="1">MTEPFIVADLDGTLLHDGKTFEQRALSDYTIHTVDTLHRNHVPFVVATARPVSTGLDMVRRLHADACIYLNGALIDFHPATSDYAMLTGTKSTPNGQLLKIGFSSDYACEVCRSIAHVIPDIEIGIVMDDVRYTNFDVSKYWKTQTWRFTDFTDVPEGTADKIIIFPTNEQTPLLSTLLPDELSLNISEGSLWMLMDPHANKQYTMELLCDRWNIDLNNVVAFGDDIIDIDMMQRAGTGVAVANSNPKVLNIADEICASNNDDGVAKWIEHRIFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUI1</accession>
    <name>B8DUI1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipase/Carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217913.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1375"/>
    <dbReference type="EnsemblBacteria" id="ACL29660">
        <property type="protein sequence ID" value="ACL29660"/>
        <property type="gene ID" value="BLA_1375"/>
    </dbReference>
    <dbReference type="GeneID" id="66533205"/>
    <dbReference type="KEGG" id="bla:BLA_1375"/>
    <dbReference type="HOGENOM" id="CLU_079831_0_0_11"/>
    <dbReference type="OMA" id="DMAHAIC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_2" evidence="1">
        <location>
            <begin position="11"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="209" mass="23995" checksum="DC62F13C6317DB8D" modified="2009-03-03" version="1">MLNALCHVHDDSSPLFLMFHGYGNDEHEMIRVIEAVGRHDPMSYISFRAPFEREYMGGYSWYPHGCGPEARRRLADESIGGIRRLLDSPICRNRPTVCIGFSQGGYMSLRMVLAEPTMFDAAILMSPSFVGGLSDDERERLMHSRTRFLLCYGEDDTTIPRADQCRLRECLQRTGRLTYRDYPQTAHAIVAPEIQDIREFIQEMVTHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUI9</accession>
    <name>B8DUI9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cpsY</name>
        <name evidence="3" type="ordered locus">BLA_1383</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217901.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1383"/>
    <dbReference type="EnsemblBacteria" id="ACL29668">
        <property type="protein sequence ID" value="ACL29668"/>
        <property type="gene ID" value="BLA_1383"/>
    </dbReference>
    <dbReference type="GeneID" id="66533213"/>
    <dbReference type="KEGG" id="bla:BLA_1383"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1447"/>
    <dbReference type="HOGENOM" id="CLU_039613_32_2_11"/>
    <dbReference type="OMA" id="FHFSEEI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="308" mass="35222" checksum="F8EBD9ABFFD53568" modified="2009-03-03" version="1">MTLLQLRYIVKIVECGSMNEASHALYVSQPALSSSVKELENELGIEIFTRSSQGIALTVDGAEFLTYARQVLDQADLLEERYKNAKPRKQLCSVSTQHYMFAVEAFVEMINSFKSDEYEFTIRETRTKDIINQVANMRSEIGILYLSDYNTHVIGKMLREKHLEFHPLFRAPLHVFISKDNPLSMKKKVTMDDLKPFPFIQYEQGEEGSFFFAEEAVWPEYSPKQINVTDRATILNFIIGLNGYTVCTGIDNGDLNNEKIMTIPLDTDETMLLGWITNERAKLSKAAQTYLDKLKEVIANHGYTIISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUK4</accession>
    <name>B8DUK4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutamate-ammonia-ligase adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glnE</name>
        <name evidence="5" type="ordered locus">BLA_1398</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217884.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1398"/>
    <dbReference type="EnsemblBacteria" id="ACL29683">
        <property type="protein sequence ID" value="ACL29683"/>
        <property type="gene ID" value="BLA_1398"/>
    </dbReference>
    <dbReference type="GeneID" id="66533227"/>
    <dbReference type="KEGG" id="bla:BLA_1398"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1462"/>
    <dbReference type="HOGENOM" id="CLU_006233_1_0_11"/>
    <dbReference type="OMA" id="EFMVQYA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008882">
        <property type="term" value="F:[glutamate-ammonia-ligase] adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023057">
        <property type="entry name" value="GlnE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005190">
        <property type="entry name" value="GlnE_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013546">
        <property type="entry name" value="PII_UdlTrfase/GS_AdlTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30621">
        <property type="entry name" value="PTHR30621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08335">
        <property type="entry name" value="GlnD_UR_UTase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03710">
        <property type="entry name" value="GlnE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GlnE" evidence="3">
        <location>
            <begin position="130"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="GlnD_UR_UTase" evidence="4">
        <location>
            <begin position="370"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="GlnE" evidence="3">
        <location>
            <begin position="632"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="GlnD_UR_UTase" evidence="4">
        <location>
            <begin position="895"/>
            <end position="1039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="1044" mass="117283" checksum="A7387580415DC61B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUN3</accession>
    <name>B8DUN3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tnp1249a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1427"/>
    <dbReference type="EnsemblBacteria" id="ACL29712">
        <property type="protein sequence ID" value="ACL29712"/>
        <property type="gene ID" value="BLA_1427"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1427"/>
    <dbReference type="HOGENOM" id="CLU_062186_3_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="157" mass="18116" checksum="B73CBEF70B867BAB" modified="2009-03-03" version="1">MLAERTYAKDHPDDPKAATSRSGWWWTHLPLRRAYFRLERLFNDGTLFCLFDPTLSAHSPVPRDSDRLEGGLNAALKRMLVNHRGLPEAHMRRACEWHCYMHSAKPDPAHILKQHDQNTKTGTNHDNNDEPMSQPTLGTGIDWNEFHTATRYPDTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUN7</accession>
    <name>B8DUN7_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Cysteine desulfurase</fullName>
            <ecNumber evidence="4 6">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BLA_1431</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4 6"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217840.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1431"/>
    <dbReference type="EnsemblBacteria" id="ACL29716">
        <property type="protein sequence ID" value="ACL29716"/>
        <property type="gene ID" value="BLA_1431"/>
    </dbReference>
    <dbReference type="GeneID" id="66533261"/>
    <dbReference type="KEGG" id="bla:BLA_1431"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1495"/>
    <dbReference type="HOGENOM" id="CLU_003433_2_5_11"/>
    <dbReference type="OMA" id="HKLCGPT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01979">
        <property type="entry name" value="sufS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="7">
        <location>
            <begin position="24"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="423" mass="45236" checksum="103EF37462635477" modified="2009-03-03" version="1">MTDITAIRDQFPILDQQINGHPLVYLDSGATAQKPQCVIDAESRFYETVNAGVHRGAHTLAGLSTVAFEQARAKVATLVGASAEEGNEELVVTMGATDGLNTLATAFGNASLGRGGKVAERFALKPGDEIVVSRAEHHSVLLPFQELASRTGATLKWFDLDDDGRILSNTADEVITERTKVVAVTHVGNVTGAITDIAPIIKRTHEVGGVFILDACQSVPHIPVDFHALDVDFAVFSAHKMYGPTGVGFLYGKRDLLEALPPAKFGGSMVELAFVDRPAQYMAPPARFEAGTQPVAQVVAAGVAAEWMMGIGIETIAGHERIITEELLRLAEVDGVRILGPQDGTNRIGTVAFEVDGVHPHDVGQYIDAQGIAIRVGHHCAQPIHRHFGVFASNRASSGIYNTPEDAQALVEAVEGVRRFFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUP8</accession>
    <name>B8DUP8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217827.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29727">
        <property type="protein sequence ID" value="ACL29727"/>
        <property type="gene ID" value="BLA_1443"/>
    </dbReference>
    <dbReference type="GeneID" id="66533273"/>
    <dbReference type="KEGG" id="bla:BLA_1443"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1509"/>
    <dbReference type="HOGENOM" id="CLU_670253_0_0_11"/>
    <dbReference type="OMA" id="FETISFI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="389" mass="41901" checksum="A5220CCAB5ED7914" modified="2009-03-03" version="1">MGRRDMEVGDAVAVNDNGCKGIGFVVASSDDPEKTGGVGAAGRTAYLIRWVLGKNLQHGTTMGARGESWLNDDPKRIRIDGVQGYTMPKRFMGRNVARLCKGDNEFIGLPAPHDASMRMPMVRLAAVSVVCVLSIVLSLVFVRNREQTRLPMQQSVSAESSIDGGDAGIPGSGADNPYYYDESSGWTQEDSNEGSAQSDTNTADSADDSGATAGNSGFDPDNIRGTWCRSDGVTCVKITPQTEGNTSPLVLDTSRMGDLNPLPNGQTTIPLGYVHQDNPNTSSGAQQLITQYTYRIDCEVWAQYYNNVACDGEAVHTVDMSLPDVPRSGIKFVQRPLSVTRVISTSDSPIEGLDDSNPPTRAVYLVVEPYGGRAADSVSDDTVFYWRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUQ8</accession>
    <name>B8DUQ8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217814.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1454"/>
    <dbReference type="EnsemblBacteria" id="ACL29737">
        <property type="protein sequence ID" value="ACL29737"/>
        <property type="gene ID" value="BLA_1454"/>
    </dbReference>
    <dbReference type="GeneID" id="66533284"/>
    <dbReference type="KEGG" id="bla:BLA_1454"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1521"/>
    <dbReference type="HOGENOM" id="CLU_2581946_0_0_11"/>
    <dbReference type="OMA" id="GPDQDHV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870907" evidence="1">
        <location>
            <begin position="25"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="78" mass="8797" checksum="CDADDDCC291B0EC6" modified="2009-03-03" version="1">MFKRVFWVAAGVVLGVLAVSKATAYVRANTPDKARQFLLGPDQENVGMRTLQGLIDQFRQAQQAREEELNRQYTAKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUS6</accession>
    <name>B8DUS6_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenine deaminase</fullName>
            <shortName evidence="1">ADE</shortName>
            <ecNumber evidence="1">3.5.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Adenine aminohydrolase</fullName>
            <shortName evidence="1">AAH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">add</name>
        <name evidence="3" type="ordered locus">BLA_1473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenine + H(+) + H2O = hypoxanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23688"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.2" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217788.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1473"/>
    <dbReference type="EnsemblBacteria" id="ACL29755">
        <property type="protein sequence ID" value="ACL29755"/>
        <property type="gene ID" value="BLA_1473"/>
    </dbReference>
    <dbReference type="GeneID" id="66533303"/>
    <dbReference type="KEGG" id="bla:BLA_1473"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1541"/>
    <dbReference type="HOGENOM" id="CLU_039228_7_0_11"/>
    <dbReference type="OMA" id="DERLMQR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043103">
        <property type="term" value="P:hypoxanthine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01320">
        <property type="entry name" value="ADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01962">
        <property type="entry name" value="Adenine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028892">
        <property type="entry name" value="ADE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="PTHR43114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="A_deaminase" evidence="2">
        <location>
            <begin position="14"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="341" mass="38067" checksum="8CFA8ECBDAB15C32" modified="2009-03-03" version="1">MVDGKIRQALETMPKSELHLHIEGTLEPELALTLADRNGVTLPWTDIDGLRAQYEFENLQSFLELYYALMKTLKTKDDFKDLMLAYLTRANANGVRHAEIFFDPQVHVCTNGLDFDMVLDGLLEGLEIGRERFDISGGLILSIVRDMDIDSANRILDMAAPRKTEILGIGLDSAEVGYPPAEFIDQFARARDFGWHCVAHAGEEGPAAYIRDALNLLHAERIDHGIHIQDDRELLERVARDGVPLTCCPLSNLRLQVVHDMREHPIPRFLHEGVVCTINSDDPAYFGGYAAANYAALADIGMSMEELASLAKNSIDASFASDDRKTQLHAQLATWRTQHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUT1</accession>
    <name>B8DUT1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative adenylate kinase DNA topology modulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">flaR</name>
        <name evidence="1" type="ordered locus">BLA_1478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217783.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1478"/>
    <dbReference type="EnsemblBacteria" id="ACL29760">
        <property type="protein sequence ID" value="ACL29760"/>
        <property type="gene ID" value="BLA_1478"/>
    </dbReference>
    <dbReference type="GeneID" id="66533308"/>
    <dbReference type="KEGG" id="bla:BLA_1478"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1546"/>
    <dbReference type="HOGENOM" id="CLU_092618_0_3_11"/>
    <dbReference type="OMA" id="WIWEYPN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="190" mass="21967" checksum="A0A416789999EF56" modified="2009-03-03" version="1">MRRVLVIGCPGAGKSTFARRLRDAAGLPLHYLDMLWHNPDRTTVTRAEFDERLQRILEEDAWILDGNFARTLPKRLEYCDTVFFLDFPTDVCLEGVEGCSGMKREDMPWVEHEFDEEFRQYIIDFPAERRPQMVDALEDAAARRGVRVHTTSKAELVQALADVLSGLEVGRARACLTFIMYRYATYWASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUT2</accession>
    <name>B8DUT2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014482942.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1479"/>
    <dbReference type="EnsemblBacteria" id="ACL29761">
        <property type="protein sequence ID" value="ACL29761"/>
        <property type="gene ID" value="BLA_1479"/>
    </dbReference>
    <dbReference type="GeneID" id="66533309"/>
    <dbReference type="KEGG" id="bla:BLA_1479"/>
    <dbReference type="HOGENOM" id="CLU_041527_5_1_11"/>
    <dbReference type="OMA" id="YSHEGIR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4143" evidence="1">
        <location>
            <begin position="5"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="123" mass="13969" checksum="1F369F8D897EE4A1" modified="2009-03-03" version="1">MTHRKFHAEDPGLCNIANGFSSQNYGFQLENVVANELRRRGYNVHVGSLRGGEIDFVAQRFDRRIYIQVTGTMLEESTRARELAPLQSLSDAFPKIVLTLDRFRLGTTSDGIEIRNIVDWLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUU1</accession>
    <name>B8DUU1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycogen debranching enzyme GlgX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glgX</name>
        <name evidence="5" type="ordered locus">BLA_1488</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1488"/>
    <dbReference type="CAZy" id="CBM48">
        <property type="family name" value="Carbohydrate-Binding Module Family 48"/>
    </dbReference>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29770">
        <property type="protein sequence ID" value="ACL29770"/>
        <property type="gene ID" value="BLA_1488"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1488"/>
    <dbReference type="HOGENOM" id="CLU_011725_1_1_11"/>
    <dbReference type="OMA" id="SEPWDCG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004133">
        <property type="term" value="F:glycogen debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02856">
        <property type="entry name" value="E_set_GDE_Isoamylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044505">
        <property type="entry name" value="GlgX_Isoamylase_N_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011837">
        <property type="entry name" value="Glycogen_debranch_GlgX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02100">
        <property type="entry name" value="glgX_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="4">
        <location>
            <begin position="161"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="712" mass="81742" checksum="6564189710DC4B3C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUU2</accession>
    <name>B8DUU2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Possible pyrophosphate-releasing NTPase in MutT family</fullName>
            <ecNumber evidence="3">3.6.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.13" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217760.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1489"/>
    <dbReference type="EnsemblBacteria" id="ACL29771">
        <property type="protein sequence ID" value="ACL29771"/>
        <property type="gene ID" value="BLA_1489"/>
    </dbReference>
    <dbReference type="GeneID" id="66533320"/>
    <dbReference type="KEGG" id="bla:BLA_1489"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1558"/>
    <dbReference type="HOGENOM" id="CLU_062658_5_2_11"/>
    <dbReference type="OMA" id="HVESAWV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="69"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="217" mass="24670" checksum="7AE44A67C315D155" modified="2009-03-03" version="1">MGCDSERNVESEIIDAMLDRSSDGVNMDIPARVLDSETKYRGAIFHVDDRRIALTRNNGDQIVIRRQVLVHAPCVVMLVHDCVRDTYLIEREYRAGIGRFTYGLPAGLIDHDEDPHTAALRELREETGVVADTDGDVHFDIVGDYYSSEGMTDELAHIFVLHLHAWHATHTEFDGDEHVESTWVGWDDLLTLPVTASNSIIAIQHERIRRLRELQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUU7</accession>
    <name>B8DUU7_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Pyruvate kinase</fullName>
            <ecNumber evidence="5 14">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">pyk</name>
        <name evidence="17" type="ordered locus">BLA_1494</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="5 14"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1494"/>
    <dbReference type="EnsemblBacteria" id="ACL29776">
        <property type="protein sequence ID" value="ACL29776"/>
        <property type="gene ID" value="BLA_1494"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1494"/>
    <dbReference type="HOGENOM" id="CLU_015439_9_0_11"/>
    <dbReference type="OMA" id="QVPIVQK"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 14 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 17" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="15">
        <location>
            <begin position="2"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="16">
        <location>
            <begin position="272"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ACL29776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="394" mass="42787" checksum="70B593E43E47CDE2" modified="2009-03-03" version="1">MQLTEGQEFIITTDDVEGDEHITSTTFKGLPGDCHPGDPILIDDGKVRLEVTKVEGNNVHTKVVVAGPVSSHKGINLPGVAVSLPALTEKDENDLRWAIQTGADIIAMSFVRFATDIDRAHEIMDEEGRRIPIVAKIEKPQAVENLEDIVKVFDGIMVARGDMAVEMPFEEVPLVTKRCIELSRQYAKPVIVATEVLGSMVHSPVPSRAEASDCANAVLDGADATMTSNETAVGEYPVETVKTMARISGYATEHGFDRIPHLKDLDMSSTGAVSSAAADLAEKLNAKAIVAYTQTGSTVHRVSRERPATPIYGLTTNEHTYHWLALSWGTEGIKLDEDYHDMSRKDLMTFTDEVLRKNGKVANGDKIVVLSSAQGEHLPGRTDSIYVHTVGACD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUU8</accession>
    <name>B8DUU8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral membrane protein TerC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BLA_1495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TerC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014482953.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1495"/>
    <dbReference type="EnsemblBacteria" id="ACL29777">
        <property type="protein sequence ID" value="ACL29777"/>
        <property type="gene ID" value="BLA_1495"/>
    </dbReference>
    <dbReference type="GeneID" id="66533327"/>
    <dbReference type="KEGG" id="bla:BLA_1495"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1565"/>
    <dbReference type="HOGENOM" id="CLU_045644_0_1_11"/>
    <dbReference type="OMA" id="ADHAREY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022369">
        <property type="entry name" value="Integral_membrane_TerC_rswitch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30238:SF0">
        <property type="entry name" value="PTHR30238:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03718">
        <property type="entry name" value="R_switched_Alx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="337" mass="37438" checksum="EEB04920669B526D" modified="2009-03-03" version="1">MAETPISFMIGTYVVLVVFFVVDLFVLGRRPHVPSTKECVQHIAFFVAMALVFGGLIWWVAGAKPAVEFYSGWLTEYSLSIDNLFVFVIIMSNFAVPKKLQKFVLSVGITIALVLRGLFILIGAALVSRFTWVFFIFGAFLIYTAVKVAIGEDDDEEFHENGLIRLMRRFSHITNEYDGERLRTTIDGRKYWTPMLIVFITIGTTDVMFAFDSIPAIFGLTKDPFIVFTSNVFALLGLQQLYFLLGRLLDKLVYLPVGLSLVLGFIGVKLILEALHGNTLPFINHGQPLGMVPEVPTWLSLVVIIVCIGGSALASVIKMKSIDAKQAAAPSDSQERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUV5</accession>
    <name>B8DUV5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Possible permease of ABC transporter system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BLA_1502</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217742.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1502"/>
    <dbReference type="EnsemblBacteria" id="ACL29784">
        <property type="protein sequence ID" value="ACL29784"/>
        <property type="gene ID" value="BLA_1502"/>
    </dbReference>
    <dbReference type="GeneID" id="66533334"/>
    <dbReference type="KEGG" id="bla:BLA_1502"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1572"/>
    <dbReference type="HOGENOM" id="CLU_028808_1_0_11"/>
    <dbReference type="OMA" id="LCIFWRA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="281" mass="29449" checksum="3D094DE2290FA0D4" modified="2009-03-03" version="1">MSSFFSYDPLWTQTLTMPFMRNAFLAGLCIALSAGIIGYFTIARNSTFASHALAHIALPGATGAALLGVPIALGLGVFAVGGAWVIAALGKRAGEREIATGTVLAFATGLGLYFARMSSSASQQLQAILFGSILTITPDQIIGFAIFDAVLIILMCIVYRPLLFSSLDEQVAQAKGVRVGIMNALFMTILAGVITIAVPAVGTLLIFALVVTPAATSMIITDSPFKAIVMAMVLCLVSIWGGLVISTMFPAPPSFVIVTLSTLFWGIAKGVESVRNHRNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUX7</accession>
    <name>B8DUX7_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-galactosidase</fullName>
            <ecNumber evidence="2">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aga</name>
        <name evidence="7" type="ordered locus">BLA_1524</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218969.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="SMR" id="B8DUX7"/>
    <dbReference type="STRING" id="442563.BLA_1524"/>
    <dbReference type="CAZy" id="GH36">
        <property type="family name" value="Glycoside Hydrolase Family 36"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29806">
        <property type="protein sequence ID" value="ACL29806"/>
        <property type="gene ID" value="BLA_1524"/>
    </dbReference>
    <dbReference type="GeneID" id="66533921"/>
    <dbReference type="KEGG" id="bla:BLA_1524"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1598"/>
    <dbReference type="HOGENOM" id="CLU_009640_3_1_11"/>
    <dbReference type="OMA" id="WEGIYFD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038417">
        <property type="entry name" value="Alpga-gal_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031705">
        <property type="entry name" value="Glyco_hydro_36_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031704">
        <property type="entry name" value="Glyco_hydro_36_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16874">
        <property type="entry name" value="Glyco_hydro_36C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16875">
        <property type="entry name" value="Glyco_hydro_36N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00743">
        <property type="entry name" value="GLHYDRLASE36"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_36N" evidence="6">
        <location>
            <begin position="40"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_36C" evidence="5">
        <location>
            <begin position="640"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="740" mass="81229" checksum="531E868F89E524A2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUY7</accession>
    <name>B8DUY7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Possible voltage-gated potassium channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BLA_1534</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1534"/>
    <dbReference type="EnsemblBacteria" id="ACL29816">
        <property type="protein sequence ID" value="ACL29816"/>
        <property type="gene ID" value="BLA_1534"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1534"/>
    <dbReference type="HOGENOM" id="CLU_011722_6_3_11"/>
    <dbReference type="OMA" id="CHARNRS"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="PTHR11537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans_2" evidence="10">
        <location>
            <begin position="108"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="197"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL29816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="316" mass="34757" checksum="6A72EAC651B74C9D" modified="2009-03-03" version="1">MFVLSAFFLFAYSWQILAGTHTRLCNLVINLVWVLYSIDYAISLYLAPNRWSWFKSNLILLITMILPMFQPLRLLRFVPMLHMFNRSAGTASRGRISLYAVAVVAMLIYVGALAEYSVEHKAPGATITSFPLSIWWAFVTVTTVGYGDVYPVTTLGRFIAIILMITGIAVIGIVSAMISSWVIDQVNVRPHPVIPAPAVGEDGGASPSANASTHDAGGCPDEDYTTGDEDIIDAPDPLNGSSLGPSLNPAQSRIVQAELLRLTDSVNRLHNEIEQLRRAEHRHMQASGQTARKLRWHANRNGHMPPHDSPEGDKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUZ2</accession>
    <name>B8DUZ2_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
            <shortName evidence="8">CMK</shortName>
            <ecNumber evidence="2 8">2.7.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">ispE</name>
        <name evidence="11" type="ordered locus">BLA_1539</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.148"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GHMP kinase family. IspE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.148" evidence="2 8"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218990.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1539"/>
    <dbReference type="EnsemblBacteria" id="ACL29821">
        <property type="protein sequence ID" value="ACL29821"/>
        <property type="gene ID" value="BLA_1539"/>
    </dbReference>
    <dbReference type="GeneID" id="66533937"/>
    <dbReference type="KEGG" id="bla:BLA_1539"/>
    <dbReference type="HOGENOM" id="CLU_053057_1_1_11"/>
    <dbReference type="OMA" id="ACDALWG"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050515">
        <property type="term" value="F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00061">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004424">
        <property type="entry name" value="IspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43527:SF2">
        <property type="entry name" value="PTHR43527:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010376">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="9">
        <location>
            <begin position="115"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="10">
        <location>
            <begin position="240"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL29821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="318" mass="32999" checksum="676FD5D6710FF17E" modified="2009-03-03" version="1">MSAPNGARFQTPTLRADYASVHVDCPAKTNLTLHVGERREEWGGRHALETIYCGVGIYDTVTVTAKEPGTGFSLDLAGTHLGDLAASTSDMRRNHAVLAMFAMAQASGHEPDVSISIEKRIPVAAGLGGGSADAAGTLLALNALWNLNWPVARLREIAAALGADMPFCVTGGLALGTGFGERIKDLTASDPRIEHAVGDLFADAPSGDGVHMLVGAYLSQLSTPEVYSTFDVLGAGEGDLNELQHAAVSLHPRSGVAIREAQQAGATSAFVSGSGPTVIAVVPDDRVREATRAAWQASGAVDRIIDAQAPAAPLMRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV73</accession>
    <name>B8DV73_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell division protein CrgA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">crgA</name>
        <name evidence="5" type="ordered locus">BLA_0071</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in cell division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CrgA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0071"/>
    <dbReference type="EnsemblBacteria" id="ACL28374">
        <property type="protein sequence ID" value="ACL28374"/>
        <property type="gene ID" value="BLA_0071"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0071"/>
    <dbReference type="HOGENOM" id="CLU_109805_1_0_11"/>
    <dbReference type="OMA" id="LIMSTRW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00631">
        <property type="entry name" value="CrgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009619">
        <property type="entry name" value="CrgA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06781">
        <property type="entry name" value="CrgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="64"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="203" mass="22568" checksum="789003B2C8E3F5B5" modified="2009-03-03" version="1">MITGSRLKETTQMAEEELHKTDADVSANDAADSNATVTDDVVVDAATDSEGDAVAVESETVTEEPQTDSEKKAEREEKRAEDNEKRAEEAAVVSEEEADDLSLDKIQAVLNSTIDEKDMSPQMRRMVKRQQENTKRVEESIKGTKANPSWFVPLFCAFMIVGLIWVVVFYMTAKYPIPGIGNWNLAVGFALIMIGFLMTVAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVA9</accession>
    <name>B8DVA9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolases of the alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0107"/>
    <dbReference type="EnsemblBacteria" id="ACL28410">
        <property type="protein sequence ID" value="ACL28410"/>
        <property type="gene ID" value="BLA_0107"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0107"/>
    <dbReference type="HOGENOM" id="CLU_048587_0_1_11"/>
    <dbReference type="OMA" id="EFYDYYR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="73"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="331" mass="36045" checksum="413DDBAB34EE6E93" modified="2009-03-03" version="1">MNAMTALELTPVWDKTFPQSDKVEHGKITFHNRYGIELAADVYKPKRVPANGRFKAIAVSGPFGAVKEQASGLYAQTLAERGFLTIAFDPSFTGESGGSPRAVASPDINTEDFSAAVDYLANRTDVDPEGIGIVGICGFGGLALNAAANDPRIKATVASTMYDMSRVTANGYFDADDSAAKRNEMRTQLAKQRTEDYANGDYARAGGVIDPLPDDAPQFVRDYHAYYKTPRGYHARSVNSNAGWNVTSSLPFMNMPLMTYIGEIENPALLIHGEKAHSLYFSKAAYEKLEHGVNPANKELLIIPGANHTDLYDNLNAIPFDTIAGFFTRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVC5</accession>
    <name>B8DVC5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Branched-chain amino acid ABC-type transport system permease components</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BLA_0123</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0123"/>
    <dbReference type="EnsemblBacteria" id="ACL28426">
        <property type="protein sequence ID" value="ACL28426"/>
        <property type="gene ID" value="BLA_0123"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0123"/>
    <dbReference type="HOGENOM" id="CLU_039929_3_0_11"/>
    <dbReference type="OMA" id="MAWAISA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870817" evidence="8">
        <location>
            <begin position="45"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL28426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="475" mass="49374" checksum="4125F4A3C75C8781" modified="2009-03-03" version="1">MVSQPQRRAERGRRRKGLAIVCAGIAGLLLAMLASMIGVPNAVAAEAVDKCVPNAEHGCVSGILQTQDKTPIPDVTVTLGGEEEATATTAEDGAWAFEVNADGEYTVSIDKAVAEKYKLGESGATVEIAKKSFSKQRAVVRFDKAAAGSAAETESGNADSAKSGEQTAANTAQAGDDGKGSGFWSRFWQQLYSGCIFGLMLGLMAVGMNLVYGTTGLSSFSHGEQVTLGGLMAYVGTQMLHMPVVLSAIFAVAIGALAGWVQNQLVWAPLRHKRVGVMQQMIVTIGLSMALQYIYQFFFGGDIKGIVKSVPEGIQLGPIVTNAPTLIAAAIALVTIVSVTVFLYCTRLGRATRAVSDNAALAAASGINVDSVVRIVWILSCGLAALSGVLIGIHLNGIAWNTGVTLLMLMFAAVTLGGLGTANGALVGALIVGIVADMSTLVIPSDMRYASALAILILVLLIRPQGIFGKQKRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVD4</accession>
    <name>B8DVD4_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Biotin carboxylase</fullName>
            <ecNumber evidence="1">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BLA_0132</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.4.14" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0132"/>
    <dbReference type="EnsemblBacteria" id="ACL28435">
        <property type="protein sequence ID" value="ACL28435"/>
        <property type="gene ID" value="BLA_0132"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0132"/>
    <dbReference type="HOGENOM" id="CLU_000395_3_2_11"/>
    <dbReference type="OMA" id="TRWIESD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="8">
        <location>
            <begin position="1"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="7">
        <location>
            <begin position="68"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL28435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="434" mass="46525" checksum="84997DCC30470028" modified="2009-03-03" version="1">MFVRLADEAYALGAAETADTYLNIDAMASAAVRAHADAVHPGHGFLAENADFAQAVIDAGMVWVGPKPETIRVLGSKVAARRIAAEVVEFAREHGLPIAIKAVYGGGGRGLKVVHEPDEVAAAFESAMHEAEVAFGNGDCFVERFLARLWHVEVQVLGDQFGTVLAVGTRDCSLQRRNQKLIEEAPAPFLAAETVRELERAAVAICSRAHYESAGTVGFLVDDGTMSFMEVNTHIQVEHPVTEAVTGVDLVAAQLAIAEGAPVEAVPGLESGVTPEPRGGHAMEFRINAEDPSLGFVPFPGVVESLQVPTGPGIRFDSGVAAGDSISSRYDSMIAELIVKASTRAECLRRAERALAELHIHGVPTVVPFDKAVLESADFGAGADWRADDDVSNANFRVYTRWIEEELLPNLPSETLEDWRRAGERAMGERRRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVE5</accession>
    <name>B8DVE5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lacI</name>
        <name evidence="5" type="ordered locus">BLA_0143</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218450.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0143"/>
    <dbReference type="EnsemblBacteria" id="ACL28446">
        <property type="protein sequence ID" value="ACL28446"/>
        <property type="gene ID" value="BLA_0143"/>
    </dbReference>
    <dbReference type="GeneID" id="66532518"/>
    <dbReference type="KEGG" id="bla:BLA_0143"/>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_11"/>
    <dbReference type="OMA" id="FFMELIS"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="342" mass="36904" checksum="3AC2EAEF7121DFE2" modified="2009-03-03" version="1">MVAQKAKVTIFDVAKASGVSSSAVSYALNGKPGVSDATREKVLQVARKLGWRPNGAAQSLAQSRTRRIGLVLGYDPQLLSAEPYIMRLISGLGSALEERDYSLLVRMSMDDDDEVSILEDWIATGNVDALLLLNLEIGDPRIELMKNNPQMPCLALADSSLTSGLPTLMSDDAAASGTMIRHLALFGHKNIARVAGPEELGHSYIRDAAFSEITTELGMRYRCLHTDYTPESGAEATKRLLSVEPRPTAIIYDNDVMALAGESVASVKGVRVPEDLSIISWGDSFMNVAAHPPITALSRNILESGRLAAQLMLKLIDGEDVENVEEPPYELIERASTAPAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVF1</accession>
    <name>B8DVF1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transporter, inner membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BLA_0149</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0014 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218457.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0149"/>
    <dbReference type="EnsemblBacteria" id="ACL28452">
        <property type="protein sequence ID" value="ACL28452"/>
        <property type="gene ID" value="BLA_0149"/>
    </dbReference>
    <dbReference type="GeneID" id="66532523"/>
    <dbReference type="KEGG" id="bla:BLA_0149"/>
    <dbReference type="HOGENOM" id="CLU_076147_1_1_11"/>
    <dbReference type="OMA" id="PWYEPQY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005226">
        <property type="entry name" value="UPF0014_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30028">
        <property type="entry name" value="PTHR30028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03649">
        <property type="entry name" value="UPF0014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00245">
        <property type="entry name" value="TIGR00245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL28452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="288" mass="30971" checksum="36A1D63F476E3923" modified="2009-03-03" version="1">MQQYFAIDNWGLLIAVLMVCIAAGVSALMKLGVAKSLLWATARSLVQLLAMGFILEYVIRAQNVWLVIGLIVVMLVAAAQITMSRAKGIPKGLVPLVLLSLAVTMLLMLALVGELVIRPNPWYSPQLIIPLTGMLLGNTVSALALGLSRFFNSMRERYEEVNTLLALGATPWEAAKPSITSSITLGLLPSIAMLASSGIVTIPGMMSGQIIAGQNPVNAAKYQFVILAAVSALTLLADSIILALVYKRCFISYDRYFVPPARDSVSTLDRIRRQAAERANRGPESAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVG4</accession>
    <name>B8DVG4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218476.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28465">
        <property type="protein sequence ID" value="ACL28465"/>
        <property type="gene ID" value="BLA_0163"/>
    </dbReference>
    <dbReference type="GeneID" id="66532538"/>
    <dbReference type="KEGG" id="bla:BLA_0163"/>
    <dbReference type="HOGENOM" id="CLU_1851252_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870521" evidence="2">
        <location>
            <begin position="23"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="139" mass="15579" checksum="B134A0F8FBAEB9B7" modified="2009-03-03" version="1">MRALRRFYRRNRTLVTWAVLCAASMALVGHVTWLPGADSLFTPVSGVSSFVLSPAAGGALLWRQRSRRAIRWYVVAVLLGASMPMLWGYFRNEWANLQMPTTLDGVVATVSSLAPAILFALGAFCVYRYALGGRRRRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVJ2</accession>
    <name>B8DVJ2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable MutT protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mutT</name>
        <name evidence="3" type="ordered locus">BLA_0191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619661.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0191"/>
    <dbReference type="EnsemblBacteria" id="ACL28493">
        <property type="protein sequence ID" value="ACL28493"/>
        <property type="gene ID" value="BLA_0191"/>
    </dbReference>
    <dbReference type="GeneID" id="66532566"/>
    <dbReference type="KEGG" id="bla:BLA_0191"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.200"/>
    <dbReference type="HOGENOM" id="CLU_048989_1_0_11"/>
    <dbReference type="OMA" id="RYDDWSW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="353" mass="39855" checksum="7865D6F2254B80A9" modified="2009-03-03" version="1">MSEKRTVEAAGGIVYRIVRSIGSMMAPLSANDVEVCLVHRPKYDDWSWPKGKLEINESHRHAAVREIGEETGFPVALGPFLGEVEYPLSSEGKKTRHTGRGDGKDATKHVLYWMATQISDDDNWHRREAFGPIHAVDLGEVSEIAWLSLDKARKRLTHSTDRDMLALFVDRIEEDALKATPLLLVRHAKAEPRKQWDGTEPHRPITPEGAAAAYALDRELACYNPVELATSPWTRCEQTIEMLSWQTKRERRALPPLTEEAFERDPQAAWHCFAEQIKRVLETGNTMAICMHRPVIGGMFEHLRPLCATKSLAKRLVAKSPYMATANAFALFLVQTEDGPRIIDIQKVTPIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVQ5</accession>
    <name>B8DVQ5_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-binding protein KhpA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">KH-domain protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">khpA</name>
        <name evidence="2" type="ordered locus">BLA_0254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A probable RNA-binding protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KhpA RNA-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268359.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0254"/>
    <dbReference type="EnsemblBacteria" id="ACL28556">
        <property type="protein sequence ID" value="ACL28556"/>
        <property type="gene ID" value="BLA_0254"/>
    </dbReference>
    <dbReference type="GeneID" id="66532629"/>
    <dbReference type="KEGG" id="bla:BLA_0254"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.269"/>
    <dbReference type="HOGENOM" id="CLU_132074_3_0_11"/>
    <dbReference type="OMA" id="AVKMDKR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00088">
        <property type="entry name" value="UPF0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020627">
        <property type="entry name" value="KhpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34654">
        <property type="entry name" value="PTHR34654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="77" mass="8653" checksum="C433DDFF1AFEFBD8" modified="2009-03-03" version="1">MLAQAVEHLIKNIVDFPDDVSVKSHENARGELIRVRVNPEDIGRVIGRNGRTANAVRTVIQAISDHKVRVDIMDVRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVU2</accession>
    <name>PROB_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamate 5-kinase</fullName>
            <ecNumber evidence="1">2.7.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gamma-glutamyl kinase</fullName>
            <shortName evidence="1">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">proB</name>
        <name type="ordered locus">BLA_0291</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-glutamate = ADP + L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268428.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DVU2"/>
    <dbReference type="SMR" id="B8DVU2"/>
    <dbReference type="STRING" id="442563.BLA_0291"/>
    <dbReference type="EnsemblBacteria" id="ACL28593">
        <property type="protein sequence ID" value="ACL28593"/>
        <property type="gene ID" value="BLA_0291"/>
    </dbReference>
    <dbReference type="GeneID" id="66532668"/>
    <dbReference type="KEGG" id="bla:BLA_0291"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.311"/>
    <dbReference type="HOGENOM" id="CLU_025400_2_0_11"/>
    <dbReference type="OMA" id="TVIHRDN"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0641">Proline biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000193687" description="Glutamate 5-kinase">
        <location>
            <begin position="1"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="1">
        <location>
            <begin position="285"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="181"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="223"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00456"/>
        </source>
    </evidence>
    <sequence length="377" mass="39595" checksum="AB96B7C0EB494880" modified="2009-03-03" version="1">MQTPSQEEVRRAVAAARTVVVKVGSSSLTQPSGHLDVDKLNALVGAIAQVRMLGGNIVLVSSGAIAAGFGPLGFESRPTDVATQQATASVGQGLLMAQYEMAFGRYGIRVGQLLITAEDTMQPRQYRNARRTMAKLLELGVVPIVNENDALASNEIRFGDNDRLSALIANMVRADALILLTDVDALYTAPPSEPGSHRIGFVPNITELLDQVRVGGSESGVGTGGMVTKLEAARMAAVSGIPAVLTAARNAGPALMGDEVGTAFAPVKQRGSARRLWIKFAAHPRGVLVADSGAAKAVRGGRASLLAAGVLESRGDFAAGDPVWIDDEAGNHLARGLAGYDSEEIPNMLGRNTAQLRRLLGEEYAHPLVHRDNLVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVU4</accession>
    <name>B8DVU4_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein translocase subunit SecE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">secE</name>
        <name evidence="8" type="ordered locus">BLA_0293</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268431.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0293"/>
    <dbReference type="EnsemblBacteria" id="ACL28595">
        <property type="protein sequence ID" value="ACL28595"/>
        <property type="gene ID" value="BLA_0293"/>
    </dbReference>
    <dbReference type="GeneID" id="66532671"/>
    <dbReference type="KEGG" id="bla:BLA_0293"/>
    <dbReference type="HOGENOM" id="CLU_113663_3_2_11"/>
    <dbReference type="OMA" id="WPTRNQL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005807">
        <property type="entry name" value="SecE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038379">
        <property type="entry name" value="SecE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00964">
        <property type="entry name" value="secE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="76" mass="8797" checksum="0541651D8B4180E7" modified="2009-03-03" version="1">MARKTDHGEEVIKPNVFMRIGLFIKQIIDELRKVVTPTRKQLFYWSLAVFIFVALLMVFVTAMDFGLGKLSFLIFG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVU7</accession>
    <name>RL1_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplA</name>
        <name type="ordered locus">BLA_0296</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268437.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DVU7"/>
    <dbReference type="SMR" id="B8DVU7"/>
    <dbReference type="STRING" id="442563.BLA_0296"/>
    <dbReference type="EnsemblBacteria" id="ACL28598">
        <property type="protein sequence ID" value="ACL28598"/>
        <property type="gene ID" value="BLA_0296"/>
    </dbReference>
    <dbReference type="GeneID" id="66532674"/>
    <dbReference type="KEGG" id="bla:BLA_0296"/>
    <dbReference type="HOGENOM" id="CLU_062853_0_0_11"/>
    <dbReference type="OMA" id="GWTDVDV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_L1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_L1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0810">Translation regulation</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_1000165660" description="50S ribosomal protein L1">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <sequence length="229" mass="24733" checksum="A327ADF5103AEFEB" modified="2009-03-03" version="1">MAKHSKKYREAAERIDRNNLYTPEEAIALLKSMPAYNFDQTVEAVLRLNVDPRKADQLVRGSVNLPNGTGKTAKVLVFARGPKATEALEAGADIVGDDDLVEKVANGFLDFDSVVATPDMMGKVGRLGRVLGPRGLMPNPKTGTVTMDVTKAIKDIKGGKVDFRVDKNGNLSFLFGKLSFSAEALDQNFRAVADEVKRLKPATVKGRYITKATISSTMNPGIPVDPASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVV2</accession>
    <name>B8DVV2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Propionyl-CoA carboxylase beta chain</fullName>
            <ecNumber evidence="3">6.4.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pccB</name>
        <name evidence="3" type="ordered locus">BLA_0301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.4.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268447.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0301"/>
    <dbReference type="EnsemblBacteria" id="ACL28603">
        <property type="protein sequence ID" value="ACL28603"/>
        <property type="gene ID" value="BLA_0301"/>
    </dbReference>
    <dbReference type="GeneID" id="66532679"/>
    <dbReference type="KEGG" id="bla:BLA_0301"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.321"/>
    <dbReference type="HOGENOM" id="CLU_018822_6_2_11"/>
    <dbReference type="OMA" id="YAYAECT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="30"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="284"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="543" mass="57858" checksum="45034781A172292B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVW2</accession>
    <name>B8DVW2_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="5 10">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">BLA_0311</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="5 10"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619692.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0311"/>
    <dbReference type="EnsemblBacteria" id="ACL28613">
        <property type="protein sequence ID" value="ACL28613"/>
        <property type="gene ID" value="BLA_0311"/>
    </dbReference>
    <dbReference type="GeneID" id="66532690"/>
    <dbReference type="KEGG" id="bla:BLA_0311"/>
    <dbReference type="HOGENOM" id="CLU_000404_4_1_11"/>
    <dbReference type="OMA" id="RGSIQNI"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026459">
        <property type="entry name" value="RNR_1b_NrdE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013554">
        <property type="entry name" value="RNR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="PTHR11573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08343">
        <property type="entry name" value="RNR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="SSF48168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04170">
        <property type="entry name" value="RNR_1b_NrdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIBORED_LARGE" evidence="11">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACL28613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="708" mass="79613" checksum="ED23236A87903C1F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVX6</accession>
    <name>B8DVX6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sensor protein</fullName>
            <ecNumber evidence="5">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_0325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="5"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268496.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0325"/>
    <dbReference type="EnsemblBacteria" id="ACL28627">
        <property type="protein sequence ID" value="ACL28627"/>
        <property type="gene ID" value="BLA_0325"/>
    </dbReference>
    <dbReference type="GeneID" id="66532704"/>
    <dbReference type="KEGG" id="bla:BLA_0325"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.349"/>
    <dbReference type="HOGENOM" id="CLU_000445_89_2_11"/>
    <dbReference type="OMA" id="AMLAFRW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="162"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="407" mass="44195" checksum="37DF53B2BD4F6C5D" modified="2009-03-03" version="1">MTPGEIAMAIAMGVLLIAGGYAIAYRAGRNREREREPSEAALFAGHADADAVDGERRMLAMLEEAVIVTDSSANVLVANEAAIERGLSVDGLIVDAGIRDLVQEAAQSDAAVERELELARDSQRLHVAVTAQCTADDRVTVVCADTGYRRSVDRVRRDFVTNVSHELKTPVGAIMLLAETIDDAGDDVDMIRHFAARIGVEAKRLDGLVRRLIELGRMHGDRATTRRTVDARELVRQAIIDTEVTAGARHTMVRMRDDAGENHPLPVTVDAAAVHIALKNLVENAINYSPEHAEVTVEVSRGEDQARIRVVDHGIGIPRQLQGRIFERFYRVDPARSRLTGGTGLGLSIASHHILANQGKLEVWSKPGEGSTFTVMLPLAMRDDDTPCNRDADAEGDPDGTGKEADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVX9</accession>
    <name>B8DVX9_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pstC</name>
        <name evidence="11" type="ordered locus">BLA_0328</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268506.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0328"/>
    <dbReference type="EnsemblBacteria" id="ACL28630">
        <property type="protein sequence ID" value="ACL28630"/>
        <property type="gene ID" value="BLA_0328"/>
    </dbReference>
    <dbReference type="GeneID" id="66532707"/>
    <dbReference type="KEGG" id="bla:BLA_0328"/>
    <dbReference type="HOGENOM" id="CLU_033621_1_3_11"/>
    <dbReference type="OMA" id="VIRMSVL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="90"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL28630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="326" mass="34652" checksum="D088B558F8376990" modified="2009-03-03" version="1">MSSAPKPPAQPAADSSLTKPVSGEKADRIFRGIAYACGILILVVLAAVALFLLFRAWPLIGGDQRTNSDVISSFTGGKATSFWGYVGPLLFGTVLVAALALIIAFFVSIGIALFISHYAPKRLAAMLSYIVDILAAIPSVIYGLWGGLVLVPAIYPFWNWIAEHLGWIPIFAGPASNPPRTVATVALVLAIMILPIITSITRDIFLQTPKLLEEAALGLGATKWEMIKMSVLPFARSGIISASMLGLGRALGETMAVLMILSPGLKYSFKLLQASQNQTIAANIAAQYPEADSIGVSVLIGTGLVLFVITFLVNLLARRITEKASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVY0</accession>
    <name>B8DVY0_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pstA</name>
        <name evidence="9" type="ordered locus">BLA_0329</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268507.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0329"/>
    <dbReference type="EnsemblBacteria" id="ACL28631">
        <property type="protein sequence ID" value="ACL28631"/>
        <property type="gene ID" value="BLA_0329"/>
    </dbReference>
    <dbReference type="GeneID" id="66532708"/>
    <dbReference type="KEGG" id="bla:BLA_0329"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.353"/>
    <dbReference type="HOGENOM" id="CLU_033621_2_0_11"/>
    <dbReference type="OMA" id="GIARWKA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="99"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL28631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="330" mass="35337" checksum="10A625D5B2792BF0" modified="2009-03-03" version="1">MMSEPQSTPHADAAPVIDFDKFKPTRSYTAARKRKDMVMRALIILAFVVALIPLISVLWTTLAHGIRRLNWDFLSHNMTNVIGGNQTPSGGYGGILHAIIGTLEITLGAMVISIPIGVMCAVYLIEYAGKSKLARTIHLLVDVMSGIPSIVAGLFAYSMFAILVGPGTLNGFEGSVALSLLMIPTVVKTTEEMLKIVPNDLREASLALGVTKQRTITKVVLRTALSGIVSGSILAIARVIGETAPLLMTAGYIVSTNANLFLGEMTTLPVYVYQEYSKYHANCPADAGSGCVTAIPMERAWSAALVLIVIVLILNLIGRIVAKVFAPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVZ9</accession>
    <name>B8DVZ9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268547.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0348"/>
    <dbReference type="EnsemblBacteria" id="ACL28650">
        <property type="protein sequence ID" value="ACL28650"/>
        <property type="gene ID" value="BLA_0348"/>
    </dbReference>
    <dbReference type="GeneID" id="66532730"/>
    <dbReference type="KEGG" id="bla:BLA_0348"/>
    <dbReference type="HOGENOM" id="CLU_017584_19_1_11"/>
    <dbReference type="OMA" id="YPHMPTG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019880">
        <property type="entry name" value="OxyQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03539">
        <property type="entry name" value="DapC_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="29"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="385" mass="41044" checksum="FF8D3A63BFEEC6F5" modified="2009-03-03" version="1">MGFKDFSTPYDWSRVGRYKRIAQAVPGGMVDLSVGSPVDAVPDSVRKALAVSANDANACGYPVTGGTADLRRAICEWFRGCRDVEIEAIGADVVPTVGSKEGVAMMASLLQLSSGDVVVQPRVSYPTYEIGTQVAGATVVKVDDVAAVDSWRNIPGVKAIWVNSPSNPTGAVLSAAQLHDIVNAAREIGAVVLSDECYALMNWTKANDDEGNREAAIESSPCALRADVCDGRADGVVVLYSLSKQSNMAGYRTALLAGDAQIISRMTAFRKQLGLIMPGPVQAAMAAGLRDAASVRAQHNRYHDRLGELVCALRGYGYRVNMPQGALYVWTKAKSADCWTDMKALASIGIIASPGEFYGAPEYLRFSATATDEQIHRACERLAQA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW06</accession>
    <name>RS9_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsI</name>
        <name type="ordered locus">BLA_0355</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268556.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DW06"/>
    <dbReference type="SMR" id="B8DW06"/>
    <dbReference type="STRING" id="442563.BLA_0355"/>
    <dbReference type="EnsemblBacteria" id="ACL28657">
        <property type="protein sequence ID" value="ACL28657"/>
        <property type="gene ID" value="BLA_0355"/>
    </dbReference>
    <dbReference type="GeneID" id="66532738"/>
    <dbReference type="KEGG" id="bla:BLA_0355"/>
    <dbReference type="HOGENOM" id="CLU_046483_2_0_11"/>
    <dbReference type="OMA" id="QWKINGR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_B">
        <property type="entry name" value="Ribosomal_S9_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_S9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000146434" description="30S ribosomal protein S9">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="163" mass="17424" checksum="C908C08C94AFCA8C" modified="2009-03-03" version="1">MAENTNNSAVTETEETTAAFTTETNSGAGTGTSTIAPGYGTGRRKEAVARVRLVPGTGEWKINGRTLEEYFPSKLLQREVNSPIVLLKLEGKFDAIVLVDGGGTTGQAGAIRLGVARALNAIDRDANRAALKKAGFLTRDARVVERKKAGLHKARRAPQFSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW07</accession>
    <name>B8DW07_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycogen debranching enzyme GlgX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">glgX</name>
        <name evidence="4" type="ordered locus">BLA_0356</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268557.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0356"/>
    <dbReference type="CAZy" id="CBM48">
        <property type="family name" value="Carbohydrate-Binding Module Family 48"/>
    </dbReference>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28658">
        <property type="protein sequence ID" value="ACL28658"/>
        <property type="gene ID" value="BLA_0356"/>
    </dbReference>
    <dbReference type="GeneID" id="66532739"/>
    <dbReference type="KEGG" id="bla:BLA_0356"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.382"/>
    <dbReference type="HOGENOM" id="CLU_011725_4_0_11"/>
    <dbReference type="OMA" id="VPFAEWN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004133">
        <property type="term" value="F:glycogen debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02856">
        <property type="entry name" value="E_set_GDE_Isoamylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044505">
        <property type="entry name" value="GlgX_Isoamylase_N_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011837">
        <property type="entry name" value="Glycogen_debranch_GlgX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02100">
        <property type="entry name" value="glgX_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="3">
        <location>
            <begin position="213"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="826"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="898" mass="100180" checksum="0B90C62B8FF24401" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW10</accession>
    <name>B8DW10_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CTP synthase (UTP-ammonia lyase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268563.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0359"/>
    <dbReference type="EnsemblBacteria" id="ACL28661">
        <property type="protein sequence ID" value="ACL28661"/>
        <property type="gene ID" value="BLA_0359"/>
    </dbReference>
    <dbReference type="GeneID" id="66532742"/>
    <dbReference type="KEGG" id="bla:BLA_0359"/>
    <dbReference type="HOGENOM" id="CLU_052626_4_2_11"/>
    <dbReference type="OMA" id="DGCITIV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="324" mass="35851" checksum="A08CCD665C134DD8" modified="2009-03-03" version="1">MTELDCEARRQQRCICASDSRQAKMLARRCAGGELVRVYRGMYAHAQFWRTLPPPVQIVYLARALAKSHPDWVFNGETAACVRNLQIPWHALTHRVTIACTAGPQKSDGPRLQRIRHPNMRAEIIDGIPVTPLVCTASDCVLTMEPCAAITALDGCFKTGLSTRELLRECAANGTDAVVTLLPHVNPASENGGEAYAHAVMTARYGFRKPQQQVPLTDPQTGHIYRADYYWVCDDGTVIVAELDGAQKYIDPQMTGSRSVHAVVADEREREKALERAGVHRTVRFTFDDVIHSERLHAKLHSAGVPTHFLGSTDINGYRVAIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW50</accession>
    <name>B8DW50_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribose-5-phosphate isomerase A</fullName>
            <ecNumber evidence="2">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Phosphoriboisomerase A</fullName>
            <shortName evidence="2">PRI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">rpiA</name>
        <name evidence="3" type="ordered locus">BLA_0399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268640.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0399"/>
    <dbReference type="EnsemblBacteria" id="ACL28701">
        <property type="protein sequence ID" value="ACL28701"/>
        <property type="gene ID" value="BLA_0399"/>
    </dbReference>
    <dbReference type="GeneID" id="66532782"/>
    <dbReference type="KEGG" id="bla:BLA_0399"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.427"/>
    <dbReference type="HOGENOM" id="CLU_056590_1_0_11"/>
    <dbReference type="OMA" id="YDWDEVN"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00170">
        <property type="entry name" value="Rib_5P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020672">
        <property type="entry name" value="Ribose5P_isomerase_typA_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="31"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="87"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="100"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="233" mass="25534" checksum="95FDDD23C7FE9B22" modified="2009-03-03" version="1">MDKAQQDAMKKEAGIEAAKLVKSGMIVGLGTGSTVRFLVDELGRRKQEEGLEFTGVTTSRRTQEQAEGYGIKIVNIDDVDHIDLCIDGADEVDKNFNGIKGGGAALLWEKIVAINSNRIVWIVDASKLVDVIGKFPLPVEVIPFGAMHVIERMKERGYNPTLRLDAEGKPVRTDENNYVVDLHLERIDDPAGLNEDLINMVGVVEDGLFLDMVNEVIVGDPNGPRTLINPNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW56</accession>
    <name>B8DW56_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268654.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0405"/>
    <dbReference type="EnsemblBacteria" id="ACL28707">
        <property type="protein sequence ID" value="ACL28707"/>
        <property type="gene ID" value="BLA_0405"/>
    </dbReference>
    <dbReference type="GeneID" id="66532789"/>
    <dbReference type="KEGG" id="bla:BLA_0405"/>
    <dbReference type="HOGENOM" id="CLU_099036_0_0_11"/>
    <dbReference type="OMA" id="GGRANCQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025191">
        <property type="entry name" value="DUF4125"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13526">
        <property type="entry name" value="DUF4125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="206" mass="23777" checksum="E7B4D505906E28D8" modified="2009-03-03" version="1">MSTRQTIKSIIEREWDQFQHTNNEGGRASCQGNRPMFEVMRASQFAAWPQELLTSYLADLREADAGGRNLVTEKYARMMASTAPEIYARDLEPHLPRLSEARIAQQERIIKRQLAWAHEFADRYPALGAGMRVFDTAEDSETTTSFETYLRGELATYSQRTLDLYERFVRECERRQENLTEQIIANTVRLGGYTNLDEAEAAQRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW59</accession>
    <name>B8DW59_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Possible histidine kinase sensor of two component system</fullName>
            <ecNumber evidence="9">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BLA_0408</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="9"/>
    <dbReference type="EMBL" id="CP001213">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="ACL28710">
        <property type="protein sequence ID" value="ACL28710"/>
        <property type="gene ID" value="BLA_0408"/>
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    <dbReference type="KEGG" id="bla:BLA_0408"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.436"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:protein histidine kinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="entry name" value="HATPase_C_sf"/>
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        <property type="entry name" value="Phageshock_PspC_N"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-0808">Transferase</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="171"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="202"/>
            <end position="220"/>
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    </feature>
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            <begin position="232"/>
            <end position="258"/>
        </location>
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    <feature type="domain" description="PspC" evidence="8">
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            <begin position="19"/>
            <end position="73"/>
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            <begin position="455"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        <source>
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            <dbReference type="Pfam" id="PF04024"/>
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        <source>
            <dbReference type="EMBL" id="ACL28710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="486" mass="52381" checksum="4F19FF216B37E686" modified="2009-03-03" version="1">MSQIPEHLAPPLLPAKLPLLRPKQGRVIAGVARGISMHLGVSVALVRIVFVLLACWFGVGALAYVALWIAIPEGNPVAEAARLRGTHSSRNAPLARGNASVGESESPLFVSQTLDSAQDAWYAYTGLEQSTDSPSAKDSVRRTLANASKPAIFAGIGVVLIALPSGLNAVMRFSGSQMLPIVPCLAGMGLPWLNTRARNGQAWLTLVGEGLIFTAFLVFVAQTVARNGAVPFGSAIACGFALLVAAICALIPLLMTLIRNIWQERALKEREEERADMTAHLHDGVLQTLALIQLHADDEQQVFTLARSQERELRSWLYQERTTSDRSVSAGLQEIAAQVEDTHGKPIEVVTVGDARPSAQTDALLDAARQAMVNAVTHGGEPVSVYCEADRHQVEVFVRDHGNGFDIDDIPPERLGIRESIIGRVRRRGGTVEIVSRPDWGTEVRMHMPLEAGFDSSRTSDSPTDRPAQSGDPIRPAQSTQSTQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW89</accession>
    <name>B8DW89_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="KEGG" id="bla:BLA_0439"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF218"/>
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    </dbReference>
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        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <begin position="141"/>
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    </feature>
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            <end position="351"/>
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    </feature>
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            <begin position="180"/>
            <end position="318"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ACL28740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="355" mass="38354" checksum="CCBB0E291C3AC33D" modified="2009-03-03" version="1">MQADSAMMTLLTWCPLLVGVTFFALTMAFNRRSLWSGFSAFVMLLGIGATSIVLLMTASQYVTGSLLGTLALIAISLVAVALLLFPFALGIFLIAEGIRLLRREGLSPANCLSLALGVLICSDLLVFPAIVASVHNDAVNWVFGVLSACTFYFSAQLAIYCLSSALNLIHFGKARNIAQILVLGSGLFGETVPPLLQKRIAKGIEIQRQDPHARLILSGGQGAGEDVPEGVAMKAWALAHGADPANTVCEERSRNTRENLLFSRNLFADPNGKTAIVSTGYHVFRALLLSKQLHMNAVGYGSKTPWYFSLNALLREFIAYVSMTRKWQIVILVVLLTPFWVSGVAGLVQAIQHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW92</accession>
    <name>B8DW92_BIFA0</name>
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        <submittedName>
            <fullName evidence="2">Predicted ATP-dependent endonuclease, OLD family protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">BLA_0442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ACL28743">
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        <property type="gene ID" value="BLA_0442"/>
    </dbReference>
    <dbReference type="GeneID" id="66532828"/>
    <dbReference type="KEGG" id="bla:BLA_0442"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="26"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="515" mass="57388" checksum="F18B9A45442B19BA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWA8</accession>
    <name>B8DWA8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619728.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0460"/>
    <dbReference type="EnsemblBacteria" id="ACL28759">
        <property type="protein sequence ID" value="ACL28759"/>
        <property type="gene ID" value="BLA_0460"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0460"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.489"/>
    <dbReference type="HOGENOM" id="CLU_1599510_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025241">
        <property type="entry name" value="DUF4190"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13828">
        <property type="entry name" value="DUF4190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4190" evidence="3">
        <location>
            <begin position="104"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="166" mass="18133" checksum="3585E468413D1C84" modified="2009-03-03" version="1">MTNCHPNCDSNNPYGRGLSGPPMQQEPNRTPFAQPQYGDYGAQGNAQQPYAQPQYGQYARGSGQQYGQPDYTQNMSNYAPYGQCNQSQYGNGYSPEPTTWNGLCIAGFVCSFLVPIVGLILSIIALTQINRTGEKSRGMAIAGIVISVVIWLFSFIFMASGNSIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWC3</accession>
    <name>B8DWC3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SulD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sulD</name>
        <name evidence="2" type="ordered locus">BLA_0475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268800.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0475"/>
    <dbReference type="EnsemblBacteria" id="ACL28774">
        <property type="protein sequence ID" value="ACL28774"/>
        <property type="gene ID" value="BLA_0475"/>
    </dbReference>
    <dbReference type="GeneID" id="66532860"/>
    <dbReference type="KEGG" id="bla:BLA_0475"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.504"/>
    <dbReference type="HOGENOM" id="CLU_023499_2_0_11"/>
    <dbReference type="OMA" id="GVESEQW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="289" mass="30354" checksum="D0F870665C3C0D1B" modified="2009-03-03" version="1">MTTVDCSGIDLGSNEDDMRVWTADVSWVIDDDQLVDAEDLAAHVAAIGQMMLGVPVEQLAERIAAQLANQSVFRSVTVTVHMHWKAPLRTFEQLSATVTANRQSSANPSAAAANTGGEESASTHDGALPVDPSYRDAVISLHSAALNAEQLFREVIVTLDSMPGNQVDGISPLYFVGSLNGTDGHAAVIKLSTAMGVRQLNQVLDALHTTHEGAVQLSVVATGKVGDESLHAPKGAADHHLGAAVLEPWAAMDPNASYNGDPLAYLLAMAPDSAQVGVESERWVMGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWC8</accession>
    <name>B8DWC8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-acetylhomoserine (Thiol)-lyase</fullName>
            <ecNumber evidence="5">2.5.1.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_0480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.49" evidence="5"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268811.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0480"/>
    <dbReference type="EnsemblBacteria" id="ACL28779">
        <property type="protein sequence ID" value="ACL28779"/>
        <property type="gene ID" value="BLA_0480"/>
    </dbReference>
    <dbReference type="GeneID" id="66532865"/>
    <dbReference type="KEGG" id="bla:BLA_0480"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.509"/>
    <dbReference type="HOGENOM" id="CLU_018986_4_2_11"/>
    <dbReference type="OMA" id="YMDGHGA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003961">
        <property type="term" value="F:O-acetylhomoserine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="428" mass="46337" checksum="61875742163959CD" modified="2009-03-03" version="1">MGEHVDTICVQGGYQPGNGESRTPPIIQATTFKYTSSEQMSRLFDLSETGYFYTRLQNPTNDTVAAKICEMEGGVAAMLTSSGQAANFFALFNICNEGDHIVASSAIYGGTFNLINVTMRKMGITCTFVNPDCSPEELEAAFQPNTKAVFGESISNPALIVLDFDKFAKAAHSHGVPLIVDNTFPTPINCRPFEYGVDIVTHATTKYMDGHGSCVGGAIVDSGNFDWLAHSAKFPGLCTPDDSYHGVVYAKDFGKAAFITKATAQLMRDFGSTPAPINSWIMGMHLESLGVRMERHCANARAVAQFLEDDPRISWVSCPELPTDRYHALAEKYMPNGTCGVISFGVPGGREKVSAFLDHLKMISIATHVADARSCTLYPAGTTHRQLTEEQLEEAGVGVDLVRLSCGIENPDDIIADLRQALDAVFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWD3</accession>
    <name>B8DWD3_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9 10">Xylose isomerase</fullName>
            <ecNumber evidence="2 9 10">5.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">xylA</name>
        <name evidence="13" type="ordered locus">BLA_0485</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9 10">
            <text>alpha-D-xylose = alpha-D-xylulofuranose</text>
            <dbReference type="Rhea" id="RHEA:22816"/>
            <dbReference type="ChEBI" id="CHEBI:28518"/>
            <dbReference type="ChEBI" id="CHEBI:188998"/>
            <dbReference type="EC" id="5.3.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the xylose isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.5" evidence="2 9 10"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219358.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0485"/>
    <dbReference type="EnsemblBacteria" id="ACL28784">
        <property type="protein sequence ID" value="ACL28784"/>
        <property type="gene ID" value="BLA_0485"/>
    </dbReference>
    <dbReference type="GeneID" id="66532871"/>
    <dbReference type="KEGG" id="bla:BLA_0485"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.515"/>
    <dbReference type="HOGENOM" id="CLU_037261_1_0_11"/>
    <dbReference type="OMA" id="TLAMYEI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009045">
        <property type="term" value="F:xylose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00455">
        <property type="entry name" value="Xylose_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013452">
        <property type="entry name" value="Xylose_isom_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001998">
        <property type="entry name" value="Xylose_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00688">
        <property type="entry name" value="XYLOSISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02630">
        <property type="entry name" value="xylose_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51415">
        <property type="entry name" value="XYLOSE_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 10" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="12">
        <location>
            <begin position="111"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACL28784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="450" mass="50562" checksum="12AA2B7016389BA8" modified="2009-03-03" version="1">MAGLWDIDKIEYVGRTKGLQEGLGFQYYDADKVVAGKKMKDWLRFGVAWWHTFDAPLTDPFGDGTAQRPWDGKYSDPMDNALAKVDYAFEFFTKLGAEYFCFHDRDIAPEGDTLRETNANLDRVVDKIEENMQSTGVKLLWNTSSLFTNPRFVAGASTSPFADVYAYAAAQLKHSLEIGKRLGAENYVFWGGREGYENLWVTDMKREQEHMAKFFHMCADYAKQIGMDAQFLIEPKAKEPTTHQYDFDAATACNFLRAYDLIDVFKLNLEGNHANLAGHTYQHEIRVARDNGVLGSLDANQGDMLLGWDLDEFPTNLYETTSVMWEVLDEGQIGPHGGLNFDAKPRRTSFSAEDLFRAHIAGMDSFAAGLLVADKMHQDKYIEDLVANRYGSYDSGIGKSIDDGTATLESLNDYAIDMPQSEIIASTHPDHLEDVKATINNYIIDALANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWD8</accession>
    <name>B8DWD8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28789">
        <property type="protein sequence ID" value="ACL28789"/>
        <property type="gene ID" value="BLA_0490"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0490"/>
    <dbReference type="HOGENOM" id="CLU_1297792_0_0_11"/>
    <dbReference type="OMA" id="CMPSENE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="212" mass="22893" checksum="5701709B1029A932" modified="2009-03-03" version="1">MECMPSENELTAALMRLCDGPDDHARLHMQARANHGHVVTLDCDYDAEGLTATFIEQAADAPKSQRILTTMRADTPSASAARRIAYAYRDLIGTVGNPPAVTVDLLEQRIVRIAPIVLPESQLGIAPPVRVAASAEDPCAFELHSADAHAAPNAALLRFHGTAANGFSCATIWRLEDGYASYAMVDYTAGPLNDILVDVLCTLRFYAVRGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWF3</accession>
    <name>B8DWF3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28804">
        <property type="protein sequence ID" value="ACL28804"/>
        <property type="gene ID" value="BLA_0505"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0505"/>
    <dbReference type="HOGENOM" id="CLU_3388248_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="32" mass="3346" checksum="25BB18D92E6C24C5" modified="2009-03-03" version="1">MCAIRDLRAVGRGSLAYVEAVTRDCCTGSLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWG3</accession>
    <name>B8DWG3_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="2">6.3.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate--cysteine ligase type 2 family. EgtA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269219.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0515"/>
    <dbReference type="EnsemblBacteria" id="ACL28814">
        <property type="protein sequence ID" value="ACL28814"/>
        <property type="gene ID" value="BLA_0515"/>
    </dbReference>
    <dbReference type="GeneID" id="66533644"/>
    <dbReference type="KEGG" id="bla:BLA_0515"/>
    <dbReference type="HOGENOM" id="CLU_026610_1_1_11"/>
    <dbReference type="OMA" id="DYVEWAL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035434">
        <property type="entry name" value="GCL_bact_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011556">
        <property type="entry name" value="Glut_cys_lig_pln_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34378">
        <property type="entry name" value="PTHR34378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34378:SF1">
        <property type="entry name" value="PTHR34378:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017901">
        <property type="entry name" value="GCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR017901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="423" mass="47839" checksum="984DA58C06191730" modified="2009-03-03" version="1">MTAPRVSYAHLLVQPNPRHVRSLVRFFEEGCSAPGTGGFGVEIEHLPVHNADDTAVTYGEPNGVEELLRRLRPYYDSAQEYWQDDHLVGLAREGIAISLEPGGQIETSIGILRKPKDLLELHGQFMREATPILDELDFRLVNYGYQPKSSYADIPLNPKLRYAAMNEYLGRIGQFGPCMMRASASTQVSIDYTSERDAIDKMRLGTAIGPILAWFFRNTPYFEGAPNPWPLCRQRMWDYLDVQRTNVTPGLYDERFSWEDYAADVLSTPLMFADLTHTPEAEGASVHGTEFTAFYTTAADLYPDRELNAYEINHVLSTHFNDVRLKNFIEMRHWDSLPIERAELLTQIVSNLFYDVERRTSLESYFSGLTGEDVHAAKAVLQARGGDAKPYDQPMDYWAEVLGVGDALADVPGDAKWPEVRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWG6</accession>
    <name>B8DWG6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218228.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0518"/>
    <dbReference type="EnsemblBacteria" id="ACL28817">
        <property type="protein sequence ID" value="ACL28817"/>
        <property type="gene ID" value="BLA_0518"/>
    </dbReference>
    <dbReference type="GeneID" id="66533647"/>
    <dbReference type="KEGG" id="bla:BLA_0518"/>
    <dbReference type="HOGENOM" id="CLU_129819_1_1_11"/>
    <dbReference type="OMA" id="YIFTMES"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009732">
        <property type="entry name" value="DUF1304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06993">
        <property type="entry name" value="DUF1304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="133" mass="14297" checksum="5AF96A2469EF8DFD" modified="2009-03-03" version="1">MNTALITASIFAMLAGLLHVYIFVMESFLWTSRSTRETFSMGADEAEQTKEMAFNQGFYNLFLAIMSIGGAIVLWCGVTVVGVTLMTAGSASMFCAALVLLCTAPDKHSAAIKQIFFPALTLIALLVALILFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWH0</accession>
    <name>B8DWH0_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exodeoxyribonuclease 7 large subunit</fullName>
            <ecNumber evidence="5">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Exodeoxyribonuclease VII large subunit</fullName>
            <shortName evidence="5">Exonuclease VII large subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">xseA</name>
        <name evidence="9" type="ordered locus">BLA_0522</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the XseA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="5"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218232.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0522"/>
    <dbReference type="EnsemblBacteria" id="ACL28821">
        <property type="protein sequence ID" value="ACL28821"/>
        <property type="gene ID" value="BLA_0522"/>
    </dbReference>
    <dbReference type="GeneID" id="66533651"/>
    <dbReference type="KEGG" id="bla:BLA_0522"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.550"/>
    <dbReference type="HOGENOM" id="CLU_023625_2_1_11"/>
    <dbReference type="OMA" id="WPAVRFE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04489">
        <property type="entry name" value="ExoVII_LU_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00378">
        <property type="entry name" value="Exonuc_7_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003753">
        <property type="entry name" value="Exonuc_VII_L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020579">
        <property type="entry name" value="Exonuc_VII_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025824">
        <property type="entry name" value="OB-fold_nuc-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30008">
        <property type="entry name" value="PTHR30008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02601">
        <property type="entry name" value="Exonuc_VII_L"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13742">
        <property type="entry name" value="tRNA_anti_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00237">
        <property type="entry name" value="xseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_anti_2" evidence="8">
        <location>
            <begin position="41"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="7">
        <location>
            <begin position="155"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="7">
        <location>
            <begin position="351"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL28821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="432" mass="47586" checksum="BB89669AA7139F6C" modified="2009-03-03" version="1">MVFNNGYQTGYRQGYAPAPAAGPNELPRMAAQTTAENPWPVSMVSQKFHSAVERWPAVWMEGQIIEINTRRSGSAYLTLRDNDQDVSMSVLGFGAFAQMARDYKQGDRVVVHGKADLYVKSTRLSLRADMIKRVGAGNLQEQINQLRMRLKGEGLFDESRKVALPEFPKNIGLICAPQARAEGDVVMNVNLRWPGVRFTIVHAHVQGEQCPPDIVSAIQQLDADPNVDVIIVARGGGSFEDLMGFSDERVVRATAACATPIISAIGHEDDWTLIDLAADVRASTPTDAAKRVVPDVREQQQLITEGINRMRTFIANRAGNEERLVEGYANRPSLTQPLTMLIPHERDIADAVSAMRNGLRRIVDEEQMQVERLAATLRALSPQSTLDRGYAVLQNADGAIIDDASQVQVGDELTLTLRRGKVVSQAQAVYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWI4</accession>
    <name>B8DWI4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Possible transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BLA_0536</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218251.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0536"/>
    <dbReference type="EnsemblBacteria" id="ACL28835">
        <property type="protein sequence ID" value="ACL28835"/>
        <property type="gene ID" value="BLA_0536"/>
    </dbReference>
    <dbReference type="GeneID" id="66533666"/>
    <dbReference type="KEGG" id="bla:BLA_0536"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.565"/>
    <dbReference type="HOGENOM" id="CLU_033532_0_1_11"/>
    <dbReference type="OMA" id="WFPEAGP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="284"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="472" mass="50751" checksum="49E58E6AD594528A" modified="2009-03-03" version="1">MSSKPSNLPKTADGATQAAQGSGSPYARLFRLKGAKAFCLSAAFARLPMSMMSLGIVLALNHLYDNWTVAGAMSAVYILAVAAVTPFYARLFDRFGQVKVGRVALTVQVIVMLAFAFAALARVPIPLLFVLAVVMGATQFSFGALVRTRWTYLLERTDNMDLLNTAYALEAAIDEIVFIFGPILAATLATSVHPVSQLFVPTAACAIGGGIFFSLRSTQPPVLHAVETVQVNGDDDDVRMARSGFAAQADGSHVAGQRAGVERKHRGMVSQSRRTTRNVLSYAGILPLMLAFICFNMSFTTFDVSMTGQMEADHLDRFLGLQLAMIAVGSCIGAFYFGSRQHRGSHWRRLIVCLCILTVGFMLMRVTMDIYWVLGIVELLAGLVVSPMFATGNLIVKDTVPESQLTEGLSWLTTAGQIGAAMGSLLGGMVLDHIDAHAGVMTTWVYTLAAIPFAVLGWYVASRKAQAVDPNA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWK0</accession>
    <name>Y552_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0210 protein BLA_0552</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">BLA_0552</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0210 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218276.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DWK0"/>
    <dbReference type="SMR" id="B8DWK0"/>
    <dbReference type="STRING" id="442563.BLA_0552"/>
    <dbReference type="EnsemblBacteria" id="ACL28851">
        <property type="protein sequence ID" value="ACL28851"/>
        <property type="gene ID" value="BLA_0552"/>
    </dbReference>
    <dbReference type="GeneID" id="66533682"/>
    <dbReference type="KEGG" id="bla:BLA_0552"/>
    <dbReference type="HOGENOM" id="CLU_048704_0_0_11"/>
    <dbReference type="OMA" id="EMAIGMV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd08025">
        <property type="entry name" value="RNR_PFL_like_DUF711"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01221">
        <property type="entry name" value="UPF0210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007841">
        <property type="entry name" value="UPF0210"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37560">
        <property type="entry name" value="PTHR37560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05167">
        <property type="entry name" value="DUF711"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000164862" description="UPF0210 protein BLA_0552">
        <location>
            <begin position="1"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01221"/>
        </source>
    </evidence>
    <sequence length="454" mass="47333" checksum="2AD9C973B576B7E3" modified="2009-03-03" version="1">MLNILEVHETNQMIEQEKLDVRTITMGIDLMDCVSTDLQTTCDLIYNKITSYAKDLVSTGESIERDFGIPIVNKRITVTPIALVGASCCKTSADFVQIAHALDRAAKTVGVDLIGGYSALVSKSMTPAEELLIRSLPAALSETDIVCSSVNVGSTKTGIDMNSVELLGHIIKEIAEATADIDSYGCVKFVAFCNAPDDNPFMAGGFHGVTEGDAVINVGVSGPGVVSRALDAAKGKDFEFLCETIKRTAFKITRVGQLVAQEASKRLGIPFGIIDLSLAPTPAVGDSVGEVLEKIGLAQVGAPGTTAALAMLNDQVKKGGIMASSYVGGLSGAFIPVSEDKNMIDAAESGCLTIEKLEAMTCVCSVGLDMIAIPGDTTASTISGIIADEAAIGMVNQKTTAVRVIPVVGKTVGQMANFGGLMGYAPIMPVNTASCEAFVTRGGRIPAPIHSFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWL9</accession>
    <name>B8DWL9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-ribose pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0573"/>
    <dbReference type="EnsemblBacteria" id="ACL28870">
        <property type="protein sequence ID" value="ACL28870"/>
        <property type="gene ID" value="BLA_0573"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0573"/>
    <dbReference type="HOGENOM" id="CLU_118001_0_0_11"/>
    <dbReference type="OMA" id="CRPRQDA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032582">
        <property type="entry name" value="DUF4916"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16262">
        <property type="entry name" value="DUF4916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="200" mass="22105" checksum="ABEBD0D8CD2296DE" modified="2009-03-03" version="1">MPDDGDFDAGRSRGEFDHITPEDITRGTGNPPGWLGADDIADLRSRMPIAYVEIVPVRVDDFGRVTQIGSLLRVANDQSIVERTLIAGRVLYHESLREAIARNISKDMGELALPVLPQTLTPFTVAEFFPTPGVSPYFDARQHAIALCYVVPIAGDCKPQDETLDVEWVDPHGPQITEFIEQMNDGHGTIVRQALAWVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWP0</accession>
    <name>B8DWP0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flippase Wzx</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">wzx</name>
        <name evidence="8" type="ordered locus">BLA_0594</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619777.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0594"/>
    <dbReference type="EnsemblBacteria" id="ACL28891">
        <property type="protein sequence ID" value="ACL28891"/>
        <property type="gene ID" value="BLA_0594"/>
    </dbReference>
    <dbReference type="GeneID" id="66533722"/>
    <dbReference type="KEGG" id="bla:BLA_0594"/>
    <dbReference type="HOGENOM" id="CLU_022017_0_0_11"/>
    <dbReference type="OMA" id="RTQYLIP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="326"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="478" mass="52874" checksum="1AB9B1D6FACBFA29" modified="2009-03-03" version="1">MSNSLAKNSIFNVCYQLLNVIFPLISASYVARVLMPSGVGLVAMAQNWVAYFVIFASLGIPNYAIREVAHARDSKAGTKRVFTELISINAISTTLAAIAYCAMIFVVPNFKENLVLYIVCGGSILLNYINVDWIYQGLEDYSFIAVRSFIVKLVSLAALFVFVRSQNDYVWYALIGVCAIGLNNIFNVGHLHKLNIGLGFSNIELKKHIKPIILIFSTIISIKLYTLLDVTILGLMSNNAAVAYYTNADKIIRIIITVITAVGGVLLPRISRYKVEKRYEECASIVSRVFEILFFCFLPIGIGLICTSRQLVLILFGDAYSAGILTMQIMSLLIYALGFSNLFGTQVLLAFDQEKKLLYCTIGGALINITLNLALIPLLSQNGTAVASVASETFVTATTAWFASKTLSFGIRKNVIWKTVVSTLIMTIIVEVFNFVIKNVFFSFITCVLMGGVSFLLSSVMLKNPILNYIVNVLRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWP8</accession>
    <name>B8DWP8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0602"/>
    <dbReference type="EnsemblBacteria" id="ACL28899">
        <property type="protein sequence ID" value="ACL28899"/>
        <property type="gene ID" value="BLA_0602"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0602"/>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_11"/>
    <dbReference type="OMA" id="GVRTSWG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="345" mass="38940" checksum="CD15C82E80D954A5" modified="2009-03-03" version="1">MELSGKTILITGAAGFIGWNLAERLLHSYPDITIVGLDNLNDYYDVKLKEARLERLTKYPNLIFEKGDLSDKKLIGRLFEKHHFDVVVNLGAQAGVRYSITNPDAYVSSNLIGFYNILEACRHNPVEHLVYASSSSVYGGNKKVPFSTEDKVDNPVSLYAATKKSNELMAHAYSKLYDIPSTGLRFFTVYGPAGRPDMAYFGFTNKLLAGETIKIFNYGNCQRDFTYIDDIVEGIVRVIQGAPTRQTGEDGLPVPPYALYNIGCGHPENLLDFVTTLQEELIRAEVLPDDYDFEAHKELVPMQPGDVPVTYADTEALTRDYGYRPTTSLRDGLRRFAEWYKQYYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWQ2</accession>
    <name>B8DWQ2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218347.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0610"/>
    <dbReference type="EnsemblBacteria" id="ACL28903">
        <property type="protein sequence ID" value="ACL28903"/>
        <property type="gene ID" value="BLA_0610"/>
    </dbReference>
    <dbReference type="GeneID" id="66533741"/>
    <dbReference type="KEGG" id="bla:BLA_0610"/>
    <dbReference type="HOGENOM" id="CLU_071415_1_0_11"/>
    <dbReference type="OMA" id="LDDPWGR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="3">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="188" mass="20849" checksum="D66EB03E641DE30A" modified="2009-03-03" version="1">MKVLFVCTGNICRSPMGELLFPHFFHTNGIETDSAGTQGLVDSPIDPSSAKLMALDGIDSSQFRSKRLTPQLAMSSDLILCFTEHQRRKIVALAPRVRSKTFLLSDFANLCRYFGQNNLLHGSNVEDRMREVMCNASMARRALPEAEDIADPYRKEFAAFQVAHDQIGYAIADIAQALEPSRAGHATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWR6</accession>
    <name>B8DWR6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219188.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0624"/>
    <dbReference type="EnsemblBacteria" id="ACL28917">
        <property type="protein sequence ID" value="ACL28917"/>
        <property type="gene ID" value="BLA_0624"/>
    </dbReference>
    <dbReference type="GeneID" id="66533755"/>
    <dbReference type="KEGG" id="bla:BLA_0624"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.654"/>
    <dbReference type="HOGENOM" id="CLU_046120_0_0_11"/>
    <dbReference type="OMA" id="QPRNMSM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="317" mass="34241" checksum="3C6CC4AA829FEB1B" modified="2009-03-03" version="1">MPEREIKPGISLAGAIDLEGLKHQVKAEPGQAGGAPAAGGYVIDVTQNNFQAVAQASATYPIVIFMWVPTDNRLFDMARELGDAVNGMDGKLQLARIDVSREPEIAQAFGVQGAPALFALIGGRPMPILQGMPQGDEMTQITTQVLPQLVQVAAQAGVTGTAPYITPQNADDEEDTQKEPAVPPEHAEAHRLAQEGDYAGAADAYEQVLEREPDDELAKRGRAKALLLARSANADVREAREKAAANPDDLDAQLAVADVDMIGGQIQDAFDRLLDYLAAHPDAVEPIRERMLEYFLIPEATDERLARARRRLATLMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWT3</accession>
    <name>B8DWT3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28934">
        <property type="protein sequence ID" value="ACL28934"/>
        <property type="gene ID" value="BLA_0641"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0641"/>
    <dbReference type="HOGENOM" id="CLU_1923491_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="163" mass="18423" checksum="01F6D211C4746A34" modified="2009-03-03" version="1">MAVPKCRSEPQLRHSIFTVFTFVIFEPVQGEPMDFITKAQLFAQDHFIVIAIVLFALLAVCAFFIARHNSRAARKHDTLCAKPLSLSPDEEKAVKVRYARKPKRVIFLLPAALTTDEDVNAWADAVAPRLGHAFQAVNVETIPQGLFSRAKYRVTFARLEELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWU4</accession>
    <name>B8DWU4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Collagen adhesion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_0652</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0652"/>
    <dbReference type="EnsemblBacteria" id="ACL28945">
        <property type="protein sequence ID" value="ACL28945"/>
        <property type="gene ID" value="BLA_0652"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0652"/>
    <dbReference type="HOGENOM" id="CLU_239350_0_0_11"/>
    <dbReference type="OMA" id="IAWRITS"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023849">
        <property type="entry name" value="CHP03934_TQXA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041033">
        <property type="entry name" value="Prealbumin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013552">
        <property type="entry name" value="Thioester_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041100">
        <property type="entry name" value="TQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17802">
        <property type="entry name" value="SpaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08341">
        <property type="entry name" value="TED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18202">
        <property type="entry name" value="TQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03934">
        <property type="entry name" value="TQXA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1783"/>
            <end position="1805"/>
        </location>
    </feature>
    <feature type="domain" description="TED" evidence="3">
        <location>
            <begin position="139"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="SpaA" evidence="4">
        <location>
            <begin position="350"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="TQ" evidence="5">
        <location>
            <begin position="1096"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="domain" description="TQ" evidence="5">
        <location>
            <begin position="1207"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="domain" description="TQ" evidence="5">
        <location>
            <begin position="1337"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="domain" description="TQ" evidence="5">
        <location>
            <begin position="1469"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="domain" description="TQ" evidence="5">
        <location>
            <begin position="1630"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="926"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL28945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="1811" mass="193360" checksum="D247CFB34A6394A7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSK0</accession>
    <name>B8DSK0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219098.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28979">
        <property type="protein sequence ID" value="ACL28979"/>
        <property type="gene ID" value="BLA_0686"/>
    </dbReference>
    <dbReference type="GeneID" id="66533819"/>
    <dbReference type="KEGG" id="bla:BLA_0686"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.715"/>
    <dbReference type="HOGENOM" id="CLU_2056779_0_0_11"/>
    <dbReference type="OMA" id="KRYAAEW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="119" mass="13208" checksum="779228F08CBD65B3" modified="2009-03-03" version="1">MKRYAVEWIIFALGVIALGGVMIGLPEMDKVWLWVLWGALALWVAAYVYVLRFCTTGFRALSIVVYVLAWVLIAARVGLFELGSMPQDAATSLSDLLLAGVLILVSLGWIRDPRSNEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSK7</accession>
    <name>B8DSK7_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosyl pyrophosphate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">prsA</name>
        <name evidence="4" type="ordered locus">BLA_0693</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269239.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0693"/>
    <dbReference type="EnsemblBacteria" id="ACL28986">
        <property type="protein sequence ID" value="ACL28986"/>
        <property type="gene ID" value="BLA_0693"/>
    </dbReference>
    <dbReference type="GeneID" id="66533826"/>
    <dbReference type="KEGG" id="bla:BLA_0693"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.723"/>
    <dbReference type="HOGENOM" id="CLU_033546_2_0_11"/>
    <dbReference type="OMA" id="WSRAPIS"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="3">
        <location>
            <begin position="14"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="337" mass="37012" checksum="F1550E3AE11EDA30" modified="2009-03-03" version="1">MSAVLEGTPDKRLALVTGRAYPEQATETAHYLGTEVLPTTAYDFANGEMYVRYTEPIRGADVFIMQAHTQPINKWIMEQLIMIDAAKRASARSITVVAPFFGYSRQDKKHLGREPITAKLMFTLMRAAGADRVMTVDLHAAQEQGFFNGPVDHLTAMPILLDYMRDRLPLDNTTIVSPDAGRIKVSEQWAAKLGGLPLAFIHKTRDTTRPNHAEAHGIIGEVKDRDCVVIDDMIDTAGTICEAVRTLHDHGAKSVTLVATHGLLSGPAVERLKDSGVKEIVLTDTVPIPEEKRLPNMTVLSAAPLLAAGIRSVFESRSVSNLLNGLPEDMHTRHIYA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSQ0</accession>
    <name>RL20_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplT</name>
        <name type="ordered locus">BLA_0736</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218699.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DSQ0"/>
    <dbReference type="SMR" id="B8DSQ0"/>
    <dbReference type="STRING" id="442563.BLA_0736"/>
    <dbReference type="EnsemblBacteria" id="ACL29029">
        <property type="protein sequence ID" value="ACL29029"/>
        <property type="gene ID" value="BLA_0736"/>
    </dbReference>
    <dbReference type="GeneID" id="66533497"/>
    <dbReference type="KEGG" id="bla:BLA_0736"/>
    <dbReference type="HOGENOM" id="CLU_123265_0_0_11"/>
    <dbReference type="OMA" id="GRRKNVW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000193938" description="50S ribosomal protein L20">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <sequence length="127" mass="14833" checksum="66D8B99B7EDD82BE" modified="2009-03-03" version="1">MARVKRAVNAHKKRRTVLERAKGYRGQRSRLYRKAKEQLLHSFNYNYRDRKARKGDFRKLWIQRINIAVRNEGITYNRFIQGLRLAGIELDRRALAELAVNDPDTFKTIVEQAKAALPEDVNAPVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSQ8</accession>
    <name>B8DSQ8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218691.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0744"/>
    <dbReference type="EnsemblBacteria" id="ACL29037">
        <property type="protein sequence ID" value="ACL29037"/>
        <property type="gene ID" value="BLA_0744"/>
    </dbReference>
    <dbReference type="GeneID" id="66533505"/>
    <dbReference type="KEGG" id="bla:BLA_0744"/>
    <dbReference type="HOGENOM" id="CLU_2258229_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="103" mass="11490" checksum="D3FAFF2812309884" modified="2009-03-03" version="1">MSKGISQPLDEHDEPVSLDDLHNSNDASAPQVEGECFDPSSCCDAREQVMIAAMKAYLRPQQAPECLYERLKMTLDKCCGEVITEHTVVTSHTIIHHTHRQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSR4</accession>
    <name>B8DSR4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0750"/>
    <dbReference type="EnsemblBacteria" id="ACL29043">
        <property type="protein sequence ID" value="ACL29043"/>
        <property type="gene ID" value="BLA_0750"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0750"/>
    <dbReference type="HOGENOM" id="CLU_062581_0_0_11"/>
    <dbReference type="OMA" id="VTHIACA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="150"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="346" mass="37907" checksum="C1936F37F062E538" modified="2009-03-03" version="1">MLVFEWLTYWPDLNGFETALSTLIPVLTLGVAIMPVPFSLSIIVVEVLRGIFYIFPVVHSGPTVYYSVWLALIVIGYEMPAKYAIPITVIAALDTMVDNAIFQVPFDANDIGFAATFLLDGFAGLAIRRNKEFARLRYEQREQAKQIHLVRTLHDDIGGSLSYALLLCRNAQAETDPDTLRTSLETITQTVESTLADLRTNIITPLSASTPASTAISRNVDESTTTGSCARLCQNVLRQPALLEQAGFNGTIHVSGEATDESANLVNICLTEICNNILKHGTHSYVVRIRFGERTTLVASNEIAAGEAQPDSAHHGLEMLESRLHDLGAAMTVSEEDGIWTLAIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSS4</accession>
    <name>B8DSS4_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218671.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29053">
        <property type="protein sequence ID" value="ACL29053"/>
        <property type="gene ID" value="BLA_0760"/>
    </dbReference>
    <dbReference type="GeneID" id="66533520"/>
    <dbReference type="KEGG" id="bla:BLA_0760"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.791"/>
    <dbReference type="HOGENOM" id="CLU_140176_15_3_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="13"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="68" mass="8000" checksum="5F4E654B6C8FEDF9" modified="2009-03-03" version="1">MATDTPKTTTRELLDIKQVAERIGMSATTIYHKRRTHKDEVPPAIRIGRKLFWRPKDVDQWIDNRPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSV9</accession>
    <name>B8DSV9_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glnA</name>
        <name evidence="5" type="ordered locus">BLA_0796</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218616.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0796"/>
    <dbReference type="EnsemblBacteria" id="ACL29088">
        <property type="protein sequence ID" value="ACL29088"/>
        <property type="gene ID" value="BLA_0796"/>
    </dbReference>
    <dbReference type="GeneID" id="66533558"/>
    <dbReference type="KEGG" id="bla:BLA_0796"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.829"/>
    <dbReference type="HOGENOM" id="CLU_017290_1_3_11"/>
    <dbReference type="OMA" id="TFYTHPE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="4">
        <location>
            <begin position="104"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="445" mass="50144" checksum="D523F19B41179CE4" modified="2009-03-03" version="1">MDKQQEFALRTVEERDVRFIRLWFTDVLGTLKSVAIAPAELEAAFEEGIGFDGSAIEGMTRVSEDDMIVKPDPSTFQILPWRGGPQGTARMFCDVLTPEGEPSLSDPRHVLKRSLSKAKEKGFTFYVHPEIEFYLFEKQDDWSKSPVPIDQGGYFDHVPRSPGMDFRRATVNMLEQMGISVEYSHHEAGPGQNEIDLRYADALTIADNIMTFRTVVKEISLERGIHASFMPKPLADAPGSGMHTHLSLFEGDANAFYEAGQEFNMSLTARQFAAGILHHAAEICAVTDQYVNSYKRLWGGNEAPSYICWGHNNRSALLRIPQYKPGKGNSARIEFRALDPGANPYLAYSVLLAAGLDGIEKKMTLGEPTSDDVWELTDAERQAMGIQPLPESLDEALKIMEKSDFVADVLGEHLFEFFLRNKRKEWEEYRSQVTPFELKKYLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSX9</accession>
    <name>B8DSX9_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine_BP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218591.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0816"/>
    <dbReference type="EnsemblBacteria" id="ACL29108">
        <property type="protein sequence ID" value="ACL29108"/>
        <property type="gene ID" value="BLA_0816"/>
    </dbReference>
    <dbReference type="GeneID" id="66533578"/>
    <dbReference type="KEGG" id="bla:BLA_0816"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.850"/>
    <dbReference type="HOGENOM" id="CLU_137479_1_1_11"/>
    <dbReference type="OMA" id="AMFTSIE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="SSF89957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine_BP" evidence="2">
        <location>
            <begin position="27"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="122" mass="13186" checksum="57A19E738E0F2CEB" modified="2009-03-03" version="1">MNSPDRNAVRQEVPVDEHGKPIINTVAAVAIAPSGVGAELSEYVAEAVEVIRESGLPNETNAMFTNIEGNLDDVLKAVRDATVKLAEQGYRTGVTLKLDIRPGFSGQISEKQQLVDEILTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSY1</accession>
    <name>B8DSY1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cscB</name>
        <name evidence="2" type="ordered locus">BLA_0818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218589.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0818"/>
    <dbReference type="EnsemblBacteria" id="ACL29110">
        <property type="protein sequence ID" value="ACL29110"/>
        <property type="gene ID" value="BLA_0818"/>
    </dbReference>
    <dbReference type="GeneID" id="66533580"/>
    <dbReference type="KEGG" id="bla:BLA_0818"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.852"/>
    <dbReference type="HOGENOM" id="CLU_055585_0_0_11"/>
    <dbReference type="OMA" id="HGPYYTF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000576">
        <property type="entry name" value="LacY/RafB_perm_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01306">
        <property type="entry name" value="LacY_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00174">
        <property type="entry name" value="LACYSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00882">
        <property type="entry name" value="2A0105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="441" mass="48961" checksum="5D23E7DD2174E05F" modified="2009-03-03" version="1">MATTTKVWRNPSYLQSSTGIFLFFCSWGIWWSFFQRWLNSMGLNGAEVGTIYSINSLATLILMFGYGLIQDNLGLKRRLVLVISAIAALVGPFVQFVYAPLMRTNMMAAALVGSVVLSAGFMAGCSLIEAVTERYSRRFNFEYGQSRAWGSFGYAIVALVAGFVFNINPMINFWLGSAFGVGMLIVYLTWYPAEQREALKEAADPNAAPTNPTIKDMLGVLKMPTLWVLIVFMLLTNTFYTVFDQQMFPTYYASLFPNEATGNAVYGTLNSVQVFCESAMMGVVPIIMRKVGVRNALLLGSTVMFLRIGLCGIFHDPVSISIVKMFHAIEVPLFCLPAFRYFTLHFNPKLSATLYMVGFQIASQIGQVVFSTPLGMLHDRMGDRTTFLTISAIVLAATVYGFFVIKRDDEQVDGDPFIRDSKKLPSLATDEAILSADSEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT09</accession>
    <name>B8DT09_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Permease protein of ABC transporter system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BLA_0846</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218546.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0846"/>
    <dbReference type="EnsemblBacteria" id="ACL29138">
        <property type="protein sequence ID" value="ACL29138"/>
        <property type="gene ID" value="BLA_0846"/>
    </dbReference>
    <dbReference type="GeneID" id="66533608"/>
    <dbReference type="KEGG" id="bla:BLA_0846"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.881"/>
    <dbReference type="HOGENOM" id="CLU_019602_1_0_11"/>
    <dbReference type="OMA" id="IGLHYST"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="18"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="218" mass="24467" checksum="3D7229433C3DD645" modified="2009-03-03" version="1">MFDWAFVAKYAPFFVNGAWMTLFISVFGIALAILTGIICAAIETARIPVLRQITTVYIEVSRNTPLLVQLYFLYFGLPKMGFVWSAELCAIVGLGFLGGSYMAESMRAGLQSVPQIQRENAYMLGFNTWQTLTRVIVPQAVSISTPGIVANVIFLIKESSVVSAIALADVMYMAKDLMGMYYNTYEALFMLIVTYLIILLPISILGTWLERRFDYARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT10</accession>
    <name>B8DT10_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218545.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0847"/>
    <dbReference type="EnsemblBacteria" id="ACL29139">
        <property type="protein sequence ID" value="ACL29139"/>
        <property type="gene ID" value="BLA_0847"/>
    </dbReference>
    <dbReference type="GeneID" id="66533609"/>
    <dbReference type="KEGG" id="bla:BLA_0847"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.882"/>
    <dbReference type="HOGENOM" id="CLU_017584_4_5_11"/>
    <dbReference type="OMA" id="NDECYSE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="33"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="394" mass="42644" checksum="B41B1114E780D122" modified="2009-03-03" version="1">MAIHFAKVASQIPPNVFERMDRKVLAARGRGVDVIDLSKGNPDGFPEEFIREVTRAAVDDPLNARYTPFDGKPAFLEAAANWYRNVHGVELDANRGLFAVEGAVDGLADLFSILLDEGDAVAFADPYYPSYHCMANMRGAHEVLLPAKAELGWLPDLDAVPASVWDGVRLLVLNYPNNPTGAQAPLAFFEQAVKLAVEHDFVVVHDFAYAGLGVEEQQHSLLEVVAHTPAGSPERECTVEICSLSKMYAMAGWRAGFIAGSERILDVAKNFHYQMGSMITSFVQDAGVAALNSDQTCVGRQAAHYAGRRAIVADGLRELGYDLFDSQGGLYVWMHAPAGRSGEEVADDLLDKAGVAVLPGTCFGNVGAQYVRLSLLQPDERLAEAVKRIGTCCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT16</accession>
    <name>B8DT16_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III polC-type</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dpo</name>
        <name evidence="2" type="ordered locus">BLA_0853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0853"/>
    <dbReference type="EnsemblBacteria" id="ACL29145">
        <property type="protein sequence ID" value="ACL29145"/>
        <property type="gene ID" value="BLA_0853"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0853"/>
    <dbReference type="HOGENOM" id="CLU_047806_7_3_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006054">
        <property type="entry name" value="DnaQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00573">
        <property type="entry name" value="dnaq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="10"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="123" mass="14066" checksum="6A89A02C24AED957" modified="2009-03-03" version="1">MKPASRIPMNYISLDLETTGFSAQNDRITEIGAVKVRDGKIVDRFTQLVNPGRRVSARITELTGISNEMLEDQPVIEDILGDFIHWTENDRLVGHNTKFDLSFLIANAERVFRRLHTLFRASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT43</accession>
    <name>B8DT43_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sec-independent protein TadD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219241.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0880"/>
    <dbReference type="EnsemblBacteria" id="ACL29172">
        <property type="protein sequence ID" value="ACL29172"/>
        <property type="gene ID" value="BLA_0880"/>
    </dbReference>
    <dbReference type="GeneID" id="66533859"/>
    <dbReference type="KEGG" id="bla:BLA_0880"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.920"/>
    <dbReference type="HOGENOM" id="CLU_031506_4_3_11"/>
    <dbReference type="OMA" id="PNEAPRI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="318" mass="34889" checksum="C60BEDFBC3B77592" modified="2009-03-03" version="1">MSKKHRVRDWAPLPPALPQDAHVIDNHTHVASVVPFSQALSHEAVEKGQPEIAVYSVDQLLDQAAAVGVEGVIDCGCELPHLMTAIDMAREHPGSVWAAIAIHPNEAVLHGHRGAPGPDGLPVRYKPWHDVPFDEAMTEVRRLAKAYPKQVVAIGETGMDLFRTGESAKEIQREAFRDHIAVAKELDLPMQIHDRDAHRDVIETLLADGAPRKTVFHSYSGDAEMGEIAREHGWYLSLSGASSYKGNTGILESAALVGLDHVMVETDAPYLTPMPYRGRPNAPMMIPYTLAALAEYLDTPVEQVARATRNTTREVYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT45</accession>
    <name>B8DT45_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29174">
        <property type="protein sequence ID" value="ACL29174"/>
        <property type="gene ID" value="BLA_0882"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0882"/>
    <dbReference type="HOGENOM" id="CLU_075490_0_0_11"/>
    <dbReference type="OMA" id="IMQDKDD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="260" mass="28899" checksum="6CB395E6F351FDAC" modified="2009-03-03" version="1">MERTAYSGLGMPTACAALVLGGIMQDKDDMLPKNVQQDISELTKPDVTEHESAWATYRKLPKSHKWPYFYHHFFWPIIVAVVVFAAIVAFVVNMVISPKGQGLGVAFVGVEESDRSMDKLEDGFLKYRALDEKKITFENDLYIDSSNKESASMSLDTLETQMSGGTINTIIGDDSALRSQHLLGYLEPLDNVLTSYQMGKLRERGALVTDGEGGAAKAIDLGKSAEWTRIKGQDPHAQLSFVNVQNKDYARLFVDYLFGM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT48</accession>
    <name>SYM_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="1">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">metG</name>
        <name type="ordered locus">BLA_0885</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619863.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DT48"/>
    <dbReference type="SMR" id="B8DT48"/>
    <dbReference type="STRING" id="442563.BLA_0885"/>
    <dbReference type="EnsemblBacteria" id="ACL29177">
        <property type="protein sequence ID" value="ACL29177"/>
        <property type="gene ID" value="BLA_0885"/>
    </dbReference>
    <dbReference type="GeneID" id="66533864"/>
    <dbReference type="KEGG" id="bla:BLA_0885"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.926"/>
    <dbReference type="HOGENOM" id="CLU_009710_1_2_11"/>
    <dbReference type="OMA" id="YMRMAGH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00098">
        <property type="entry name" value="Met_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="PTHR45765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="SSF57770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000199278" description="Methionine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="347"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00098"/>
        </source>
    </evidence>
    <sequence length="623" mass="69317" checksum="1AC499A256109366" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTG9</accession>
    <name>B8DTG9_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">6-phosphogluconolactonase</fullName>
            <shortName evidence="7">6PGL</shortName>
            <ecNumber evidence="5 7">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgl</name>
        <name evidence="9" type="ordered locus">BLA_1008</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="5 7"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217686.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1008"/>
    <dbReference type="EnsemblBacteria" id="ACL29298">
        <property type="protein sequence ID" value="ACL29298"/>
        <property type="gene ID" value="BLA_1008"/>
    </dbReference>
    <dbReference type="GeneID" id="66533380"/>
    <dbReference type="KEGG" id="bla:BLA_1008"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1050"/>
    <dbReference type="HOGENOM" id="CLU_053947_1_0_11"/>
    <dbReference type="OMA" id="YQLFEFE"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="PGLS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="PTHR11054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="8">
        <location>
            <begin position="10"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL29298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="263" mass="28464" checksum="06277350F63B3CC9" modified="2009-03-03" version="1">MNREHISYSTPQLLADAVAARTLLLANDILCRPDRERVDIALTGGTDGTAILRALAGSPLLDVPDWSKVHLWWGDERFVAANSAERNAVGASDALLDMLLETKRIARNQIHEMPADRRSQEELAAATDQDNAVALAAAAADYQDELEKELGENGHLDIAMFGLGPDGHFASLFPNMPQVGINDPDVLVTGVTNSPKMPPLRLSLTVPMIVRTDYVWVCGSREGKAEAMGLTFHAQNNPALPASYADAVQQVLWITDEAAGRDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTH0</accession>
    <name>B8DTH0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxppcycle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">opcA</name>
        <name evidence="1" type="ordered locus">BLA_1009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217687.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1009"/>
    <dbReference type="EnsemblBacteria" id="ACL29299">
        <property type="protein sequence ID" value="ACL29299"/>
        <property type="gene ID" value="BLA_1009"/>
    </dbReference>
    <dbReference type="GeneID" id="66533379"/>
    <dbReference type="KEGG" id="bla:BLA_1009"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1051"/>
    <dbReference type="HOGENOM" id="CLU_046988_1_0_11"/>
    <dbReference type="OMA" id="GDTDLSW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004555">
        <property type="entry name" value="G6PDH_assembly_OpcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38658">
        <property type="entry name" value="PTHR38658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10128">
        <property type="entry name" value="OpcA_G6PD_assem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="316" mass="35418" checksum="0DDBFE11D354007B" modified="2009-03-03" version="1">MILTLTDTQTDEISAKIDELHEERGEAALGRVLTLVVATDEKNLESSLCIANEASRDHPCRVIAICPSHREMTEPESERTYLDAELRVGADAGAGEIIILRPRGGLTHHLDTLVIPLLLPDTPMVVWWPTEAPANPSHDLLGQMAHTRITDAYRSSNPQRTIEDLRRNWSSKNVDLSWTRLTLWRAVLASMVDQPPHLPIQSVRITGEQDYPPMDLLAAWLTLRLNVPVTMEIEPNAQAITGVYLTRKDGELSLERRPSEEGIARISVPGQSPQAMPLPIRSMIDCMSEELGRLYPDEIYAEVLTKGWQKIHPSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTJ7</accession>
    <name>B8DTJ7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Predicted membrane protein, hemolysin III-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BLA_1038</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217725.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1038"/>
    <dbReference type="EnsemblBacteria" id="ACL29326">
        <property type="protein sequence ID" value="ACL29326"/>
        <property type="gene ID" value="BLA_1038"/>
    </dbReference>
    <dbReference type="GeneID" id="66533350"/>
    <dbReference type="KEGG" id="bla:BLA_1038"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1085"/>
    <dbReference type="HOGENOM" id="CLU_051078_2_2_11"/>
    <dbReference type="OMA" id="HEVFHSL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="PTHR20855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="6"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="294" mass="32483" checksum="86F1EF17785E7CB8" modified="2009-03-03" version="1">MTPEQVERKRAAVIEAREQALEAKANLVRTKAHAKAEKIRRKADNKAKRTIAKGEEQAAKLEGIAPREIERKIRLDVHGREKPAMRGWIHAGAAPLAIAAGIVLICLAHGAALKWACAVFMASSAFLFTNSALYHLGDWSPRVTDVLRRIDHVNIFLLIAGTYTPVSFALDDFWRKAIIIGMWSCTLIALIIHVVWINAPRWLYVPVYIIFGVSGVAFMGLFWTSPVAGPAVVWLLLAGGVCYIAGAVVYAKRWPDPWPKVFGFHEIFHIGTVFGYACHVVAIYLVVCHLAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTL3</accession>
    <name>B8DTL3_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">rpmE</name>
        <name evidence="8" type="ordered locus">BLA_1054</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269058.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1054"/>
    <dbReference type="EnsemblBacteria" id="ACL29342">
        <property type="protein sequence ID" value="ACL29342"/>
        <property type="gene ID" value="BLA_1054"/>
    </dbReference>
    <dbReference type="GeneID" id="66532883"/>
    <dbReference type="KEGG" id="bla:BLA_1054"/>
    <dbReference type="HOGENOM" id="CLU_114306_4_0_11"/>
    <dbReference type="OMA" id="WYPDAKV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00501">
        <property type="entry name" value="Ribosomal_L31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027491">
        <property type="entry name" value="Ribosomal_L31_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="70" mass="7839" checksum="AF1261D8DA661BC5" modified="2009-03-03" version="1">MQQGIHPDYHKVTVTCSCGNTFETRSTAKGDHMTVDVCSKCHPFYTGKQKILDTGGRVARFEKRYGKKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTL9</accession>
    <name>B8DTL9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oligoribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">orn</name>
        <name evidence="2" type="ordered locus">BLA_1060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218755.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1060"/>
    <dbReference type="EnsemblBacteria" id="ACL29348">
        <property type="protein sequence ID" value="ACL29348"/>
        <property type="gene ID" value="BLA_1060"/>
    </dbReference>
    <dbReference type="GeneID" id="66532889"/>
    <dbReference type="KEGG" id="bla:BLA_1060"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1108"/>
    <dbReference type="HOGENOM" id="CLU_064761_3_0_11"/>
    <dbReference type="OMA" id="AFFHYRN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="PTHR11046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="16"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="217" mass="24635" checksum="56D205724B2C8BF4" modified="2009-03-03" version="1">MVDANDALTYSPETSRMIWIDCEMTGLDIFHDELCEVSVVPTDFELNVLDKGIDLVIKPSEAAVAHMDDFVRAMHTRSGLIDEWENGLSVQEAERQVIDYVQQFIPQGVKPLLAGNSVGSDKKFLDRFMPNLMEHLHYRVIDVSTIKELARRWYPAVYENRPPKNGGHRAWADIVESLDELRYYRAAIMAPEPGPDTVQSKRIAEQIVATSVMNEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTR5</accession>
    <name>B8DTR5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NTP pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218820.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1106"/>
    <dbReference type="EnsemblBacteria" id="ACL29394">
        <property type="protein sequence ID" value="ACL29394"/>
        <property type="gene ID" value="BLA_1106"/>
    </dbReference>
    <dbReference type="GeneID" id="66532930"/>
    <dbReference type="KEGG" id="bla:BLA_1106"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1160"/>
    <dbReference type="HOGENOM" id="CLU_037162_19_1_11"/>
    <dbReference type="OMA" id="HADQPGM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="133" mass="14950" checksum="100E82F196AEB466" modified="2009-03-03" version="1">MEEPKLIKVVGAAIIKDGKVLCAQRGAGKSLAGYWEFPGGKIEAGETPQQALQREIEEELLCEIDIDKKVCTSDYLYDFGNVQLTTFLCHLIEGMPRLTEHECIEWVEPSQMPRLRWAPVDHDAVTRISGMAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTT9</accession>
    <name>B8DTT9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218851.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1130"/>
    <dbReference type="EnsemblBacteria" id="ACL29418">
        <property type="protein sequence ID" value="ACL29418"/>
        <property type="gene ID" value="BLA_1130"/>
    </dbReference>
    <dbReference type="GeneID" id="66532954"/>
    <dbReference type="KEGG" id="bla:BLA_1130"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1184"/>
    <dbReference type="HOGENOM" id="CLU_131538_1_0_11"/>
    <dbReference type="OMA" id="ITYFQPD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="137" mass="15821" checksum="4B47DBAEFA48864A" modified="2009-03-03" version="1">MTLENLHRYDDIIDLPHHRSTKHRHMSNLERAVQFMPFAALKGHDERVREVSSTPCTRIALADDERETLNDRLVEVIGQLESHPYASITYFQPEGGRDAGEYMTAEGAVRRFDQMRRVIVMEDGTRIALVNIVDIRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTU5</accession>
    <name>B8DTU5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269066.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29424">
        <property type="protein sequence ID" value="ACL29424"/>
        <property type="gene ID" value="BLA_1136"/>
    </dbReference>
    <dbReference type="GeneID" id="66532960"/>
    <dbReference type="KEGG" id="bla:BLA_1136"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1192"/>
    <dbReference type="HOGENOM" id="CLU_1145457_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="242" mass="25761" checksum="465C73E2CE539BDA" modified="2009-03-03" version="1">MSASTPAVNRVPVARQTFRAPVAEVYAALVQTLHFSAGFDVVANDDVTHSVRFRLPNDNGEYEARVIADGMHSAVIIEAPAGTAGGSAAYSRLYRELAEQIVAQSTVVPHDVIAKRRFRQAIVADNDGPRSKWAIGAVVFACGALLGALAMFSDLRPDWQVCVTLIVSLFVVCGIAFAVTGRNGKVSGRNLVLIAFAISCLASVLLLCATIVVQIRYSTTLAISETMAQTASALPLEMPKQQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTW3</accession>
    <name>CARB_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbamoyl-phosphate synthase large chain</fullName>
            <ecNumber evidence="2">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Carbamoyl-phosphate synthetase ammonia chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">carB</name>
        <name type="ordered locus">BLA_1154</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 4 Mg(2+) or Mn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CarB family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218885.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DTW3"/>
    <dbReference type="SMR" id="B8DTW3"/>
    <dbReference type="STRING" id="442563.BLA_1154"/>
    <dbReference type="EnsemblBacteria" id="ACL29442">
        <property type="protein sequence ID" value="ACL29442"/>
        <property type="gene ID" value="BLA_1154"/>
    </dbReference>
    <dbReference type="GeneID" id="66532979"/>
    <dbReference type="KEGG" id="bla:BLA_1154"/>
    <dbReference type="HOGENOM" id="CLU_000513_1_0_11"/>
    <dbReference type="OMA" id="IEPAGIH"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_B">
        <property type="entry name" value="CPSase_L_chain_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CarbamoylP_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CbamoylP_synth_lsu_CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="SSF48108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0055">Arginine biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <feature type="chain" id="PRO_1000164707" description="Carbamoyl-phosphate synthase large chain">
        <location>
            <begin position="1"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp 1" evidence="2">
        <location>
            <begin position="133"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp 2" evidence="2">
        <location>
            <begin position="681"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="3">
        <location>
            <begin position="964"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carboxyphosphate synthetic domain">
        <location>
            <begin position="1"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Oligomerization domain">
        <location>
            <begin position="403"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate synthetic domain">
        <location>
            <begin position="554"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric domain">
        <location>
            <begin position="963"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="159"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="707"/>
            <end position="773"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="840"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="852"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="852"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="854"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01202"/>
        </source>
    </evidence>
    <sequence length="1136" mass="124699" checksum="6F97BCE2F45DEE70" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTX1</accession>
    <name>FMT_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="1">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fmt</name>
        <name type="ordered locus">BLA_1162</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fmt family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619951.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DTX1"/>
    <dbReference type="SMR" id="B8DTX1"/>
    <dbReference type="STRING" id="442563.BLA_1162"/>
    <dbReference type="EnsemblBacteria" id="ACL29450">
        <property type="protein sequence ID" value="ACL29450"/>
        <property type="gene ID" value="BLA_1162"/>
    </dbReference>
    <dbReference type="GeneID" id="66532987"/>
    <dbReference type="KEGG" id="bla:BLA_1162"/>
    <dbReference type="HOGENOM" id="CLU_033347_1_0_11"/>
    <dbReference type="OMA" id="CCPVVAY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000190007" description="Methionyl-tRNA formyltransferase">
        <location>
            <begin position="1"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="111"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>(6S)-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <sequence length="321" mass="34191" checksum="2AE473BA82F06B43" modified="2009-03-03" version="1">MLRVLFAGTPEVAVPSLRMLAKDTEHFEVVAVLTRPDAPTGRGRKIMPSPVKMAARELGLDVIECDPADECFLSALKATGAQCAAVVAYGKILRESVLEALPLGWYNLHFSLLPQWRGAAPVQRAIWAGDEVTGCSVFRITAGMDRGPVLGQSTVTIGAHENAGELLDRLAEDGAGLLAASLQALDEGVVNAVDQPAGSYDVAAKITTQDAHMRFDVPAFALDRQIRACTPAPGAWANLHPHGDDANETLHVSKAIPADMTADESPRNLKPGELHVTKHHVWVGTSTDPLELLVVKAAGKREMGAPEWARGAHLAEGAYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTY4</accession>
    <name>B8DTY4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell surface elastin binding protein EbpS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ebpS</name>
        <name evidence="2" type="ordered locus">BLA_1175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1175"/>
    <dbReference type="EnsemblBacteria" id="ACL29463">
        <property type="protein sequence ID" value="ACL29463"/>
        <property type="gene ID" value="BLA_1175"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1175"/>
    <dbReference type="HOGENOM" id="CLU_111960_0_0_11"/>
    <dbReference type="OMA" id="QKATQNK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046314">
        <property type="entry name" value="DUF6466"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20070">
        <property type="entry name" value="DUF6466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="191" mass="20822" checksum="0935231C60C01A10" modified="2009-03-03" version="1">MDRATASRSFTKRAPLGVRIMLAAFAVLAIAFAVLAGVNIDAQRQYDAATQTLTENLETASRNDADLKQLLTSQQELDARFASITGKSAVLLPQISESTTYNAQVSKQLTDLVQQQVDADAAKNDSQQSGQHGEQPKSLDSLTEEQRKQVEELLRSNEELGKSEDSTNESNGGQGERENDSPSRPSNVKPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTZ5</accession>
    <name>B8DTZ5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_1186</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619957.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1186"/>
    <dbReference type="EnsemblBacteria" id="ACL29474">
        <property type="protein sequence ID" value="ACL29474"/>
        <property type="gene ID" value="BLA_1186"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1186"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1247"/>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_11"/>
    <dbReference type="OMA" id="SYPRRVW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="8"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="132"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="132"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="245" mass="27413" checksum="5E99C0C2CCFB775A" modified="2009-03-03" version="1">MSKATEATIVVVDDEPSIRELLVASLHFAGYEVETAASGSEAIEVISRTKPDMIILDVMLPDIDGFTVTRRIRQEGITAPVLFLTARDDTQDKVMGLTVGGDDYVTKPFSLEEVVARIRAILRRTREQVEDDPIIRVGDLEINEDSHDVTRAGQTIDLSSTEYKLLRYLMDNEGRVLSKAQILDHVWQYDWGGDAAIVESYISYLRKKVDDVTVTDEDGSTHKVTPLIETKRGIGYMIRAPKAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU07</accession>
    <name>B8DU07_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding protein of ABC transporter for glutamate</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gluA</name>
        <name evidence="5" type="ordered locus">BLA_1198</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218146.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1198"/>
    <dbReference type="EnsemblBacteria" id="ACL29486">
        <property type="protein sequence ID" value="ACL29486"/>
        <property type="gene ID" value="BLA_1198"/>
    </dbReference>
    <dbReference type="GeneID" id="66533023"/>
    <dbReference type="KEGG" id="bla:BLA_1198"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1260"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OMA" id="APIWVRR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="21"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="261" mass="28978" checksum="5832C643F7C8FE3D" modified="2009-03-03" version="1">MSENNTVEQLSPSGENAHHLVELEHVEKYYGNLHVLRDINLKVDKGEVLVIVGPSGSGKSTMCRTINRLETIDSGVIRIDGQALPQEGKGLAQLRAEVGMVFQSFNLFANKTILENVTLAPIKVRHMDRDQAEKEAMDLLARVGVDSQAMKMPSQLSGGQQQRVAIARSLAMHPKVMLFDEPTSALDPEMVNEVLDVMVELAQEGMTMLCVTHEMGFARKAANKIVFMADGQILERGTPDEFFEHPQTERAQEFLSKILTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU15</accession>
    <name>B8DU15_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable long-chain-fatty-acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fadD</name>
        <name evidence="3" type="ordered locus">BLA_1206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619963.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1206"/>
    <dbReference type="EnsemblBacteria" id="ACL29494">
        <property type="protein sequence ID" value="ACL29494"/>
        <property type="gene ID" value="BLA_1206"/>
    </dbReference>
    <dbReference type="GeneID" id="66533031"/>
    <dbReference type="KEGG" id="bla:BLA_1206"/>
    <dbReference type="HOGENOM" id="CLU_000022_45_5_11"/>
    <dbReference type="OMA" id="RTTYEWT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="47"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="629" mass="68558" checksum="150E5C27E2FD8A39" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU22</accession>
    <name>B8DU22_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminopyrimidine aminohydrolase</fullName>
            <ecNumber evidence="1">3.5.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tenA</name>
        <name evidence="3" type="ordered locus">BLA_1213</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-amino-5-aminomethyl-2-methylpyrimidine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:31799"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:63416"/>
            <dbReference type="EC" id="3.5.99.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17509"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:18385"/>
            <dbReference type="EC" id="3.5.99.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TenA family.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.2" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218127.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1213"/>
    <dbReference type="EnsemblBacteria" id="ACL29501">
        <property type="protein sequence ID" value="ACL29501"/>
        <property type="gene ID" value="BLA_1213"/>
    </dbReference>
    <dbReference type="GeneID" id="66533037"/>
    <dbReference type="KEGG" id="bla:BLA_1213"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1275"/>
    <dbReference type="HOGENOM" id="CLU_077537_3_0_11"/>
    <dbReference type="OMA" id="FYIIQDY"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050334">
        <property type="term" value="F:thiaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027574">
        <property type="entry name" value="Thiaminase_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04306">
        <property type="entry name" value="salvage_TenA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0784">Thiamine biosynthesis</keyword>
    <feature type="domain" description="TENA_THI-4" evidence="2">
        <location>
            <begin position="23"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="246" mass="28428" checksum="A5D5D273D1E0433C" modified="2009-03-03" version="1">MAKSMPTTITRTDLPPFASRMRQAADPVWEEGYRQPFIQELGAGTLDRSKFAFYLMQDELYLGAYAKVHALAVTKTDDREVMAWMASVQDAILHVETSLHRDYLASFGLTEEKVLHGQQSAFARAYTTNMLTTAYSGDLLDILVSVLPCAWVYADYGERLARDFAQGLEHNPCRQWIDMYKTDEFWQSSVWLLAQIERRVAGVGEERRRGLVDSFVRGVEYEYMFWASAYERQMTWKPQWEGLTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU48</accession>
    <name>B8DU48_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BLA_1239</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619976.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1239"/>
    <dbReference type="EnsemblBacteria" id="ACL29527">
        <property type="protein sequence ID" value="ACL29527"/>
        <property type="gene ID" value="BLA_1239"/>
    </dbReference>
    <dbReference type="GeneID" id="66533061"/>
    <dbReference type="KEGG" id="bla:BLA_1239"/>
    <dbReference type="HOGENOM" id="CLU_039499_1_2_11"/>
    <dbReference type="OMA" id="IMVMLVR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="84"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="289"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="18"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="350"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="374"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL29527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="459" mass="47907" checksum="5BBA70F8D9A854BD" modified="2009-03-03" version="1">MSSSYYIETSSAAAVDGGIEAVDTNNGSSQESSDNANSRTDTGTAGAGTEGAMPNDMPRDMGGQNGGPAMTTGDFSLVGFSSDEALVNAPNGSFTMNSGKAFDYDASDGNPVLVSKTLADANNLKVGSTFKLANISDSKKTYTFTVAGIYSNTQESNMPMGGPMASSANDAANAIYMSAATLGKIGLDSTKTLSITDSKGNTRETSAAQLSFTYVFDGKADYDRFTEDVRKAGLSDDYTVSSMDVEQYGQSLVPIDNLSKFARTMLIVVLSVGAVVLVILTIFNIRERKYEIGVLTAIGVKKWKVAAQFAVELLTVVLIGLIVGTGIGAATSVPVSDALLSSQVASQQSQQESRRAQFGRDMQGAPGAAPDGNAQSAKPNTDNTQGESAVPNEGKQPQSGMPQGLQHASNAIKQVNATVSWATIGWMLLIGSALTLLASLTAAIFVMRYEPLQILADRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU53</accession>
    <name>B8DU53_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218084.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1244"/>
    <dbReference type="EnsemblBacteria" id="ACL29532">
        <property type="protein sequence ID" value="ACL29532"/>
        <property type="gene ID" value="BLA_1244"/>
    </dbReference>
    <dbReference type="GeneID" id="66533066"/>
    <dbReference type="KEGG" id="bla:BLA_1244"/>
    <dbReference type="HOGENOM" id="CLU_092707_0_0_11"/>
    <dbReference type="OMA" id="REPPRYF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="262" mass="28430" checksum="987AFBAE75050129" modified="2009-03-03" version="1">MSEQEQHDTSNGVPNEPNDQHHAAPTAHGERHAINPDAAQDDVRGLVLDGRFDDDPPSVGSSNGLEYGALDSQFPATYDPYIYGHPDTDDALGAAAARAQAQRGNEYGQPSQQNAYGQQAGLPYQTQNQPGSGRQGNGGRNQPPFNLNDPSFINSMNQMNPDDPNQNPLYGHWDPGAIIAFVFALILPLPVLPALFGWFSMRRTKIYHMKGYGLAVAALVINVLYTIMWLYFLVSGVSPTEYLNQMLNTLNNGSGGSDSVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU70</accession>
    <name>B8DU70_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadK</name>
        <name evidence="7" type="ordered locus">BLA_1261</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="5"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218060.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1261"/>
    <dbReference type="EnsemblBacteria" id="ACL29549">
        <property type="protein sequence ID" value="ACL29549"/>
        <property type="gene ID" value="BLA_1261"/>
    </dbReference>
    <dbReference type="GeneID" id="66533083"/>
    <dbReference type="KEGG" id="bla:BLA_1261"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1324"/>
    <dbReference type="HOGENOM" id="CLU_008831_0_0_11"/>
    <dbReference type="OMA" id="VNLGHVG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="292"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="67"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="142"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="183"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="322" mass="35049" checksum="0E62B79FC8357D8C" modified="2009-03-03" version="1">MAKVRHAVVVTHKKLRETGTIVQDTLLQLERGGFDVTLVDTDTIPDFGTLPQTVPPETEIVVVLGGDGTILRAAELVHCTDVPIIGINMGHVGFLAEFESFQLEEAIRRICDHDYRIDERMVAHVDVWLPGTTEALSDWALNDVTIERADRGKMVEMSIGIDGVAMSSFGCDGVIVSTPTGSTAYAFSAGGPIIWPDVQALLMVPLAAHALFSRPIVIGSTSTLQFTIHDDSTSGGWICCDGRRQLALAKGTRVEIRQSASKLRLARLSDVPFTNRLVTKFNLPVEGWREQNASKHEDTDGRLLTDPQGTSLKGEGDEVDEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU99</accession>
    <name>B8DU99_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GMP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218019.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1291"/>
    <dbReference type="EnsemblBacteria" id="ACL29578">
        <property type="protein sequence ID" value="ACL29578"/>
        <property type="gene ID" value="BLA_1291"/>
    </dbReference>
    <dbReference type="GeneID" id="66533117"/>
    <dbReference type="KEGG" id="bla:BLA_1291"/>
    <dbReference type="HOGENOM" id="CLU_064068_0_0_11"/>
    <dbReference type="OMA" id="AARRDYM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005992">
        <property type="entry name" value="IMP_DH-rel2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF85">
        <property type="entry name" value="PTHR11911:SF85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01304">
        <property type="entry name" value="IMP_DH_rel_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMPDH" evidence="2">
        <location>
            <begin position="17"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="373" mass="39669" checksum="1F1C81908D9AFB18" modified="2009-03-03" version="1">MAQETEIGLGKKARIAYGLDDISIVPSRRTRDPQDVSTSWQVDAYEFDIPVIGAPMDSVTSPQTAIAMGKLGTVGVLDLEGLWTRYENPEPILEKIASLDPDDATAYLQQAYAEPIKPELIVERLHEIRDAGVTVAGALSPQRTQQYYSTVLNAGVDLFVIRGTSVSAEHVSKDHEPLNLKQFIYDLDVPVIVGGAANYRAALHLMRAGAAGVLVGFGGVATSANRQTIGVSIPMATAISDVAEARRDYMDESGGRYVQVIADGSMGESGSFVTALAMGADAAMLGAPLARAQEAPGHGTHWGSEARHATLPRGLRSEVGTVGTLQEILYGPSHKADGTTNFIGALRRAMASCGYVDIKSFQRCPVVVTANRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUC0</accession>
    <name>B8DUC0_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="2">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">lgt</name>
        <name evidence="3" type="ordered locus">BLA_1312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Lgt family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217991.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1312"/>
    <dbReference type="EnsemblBacteria" id="ACL29599">
        <property type="protein sequence ID" value="ACL29599"/>
        <property type="gene ID" value="BLA_1312"/>
    </dbReference>
    <dbReference type="GeneID" id="66533137"/>
    <dbReference type="KEGG" id="bla:BLA_1312"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1374"/>
    <dbReference type="HOGENOM" id="CLU_013386_2_0_11"/>
    <dbReference type="OMA" id="FRLNPLW"/>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00544">
        <property type="entry name" value="lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01311">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="312" mass="34502" checksum="D2AA34E8165C3F5A" modified="2009-03-03" version="1">MTTLAYIPSPSISQFHVGSLTIHIYALTMLLGIIAAVWITGERWKRLGGTFDQIFDTTLVAVPCGIVGARLYHIITTPERFFGPNGDWVEMFRIWNGGLGIWGAILCGALGAWAWCRHKHYPMALLADSIAPALLVAQAIGRLGNWFNQELYGKPTTLPWGLKLNMNGSAIGNSETCYDGASCPTGTLFHPTFLYEMIWNLIGAALIIWIGHRLANRLKAGSLFALYVMWYTLGRTWIEMLRIDFSHEILGLRVNVWVSIIVFMLGAVAFIVIQRVGSPTQLLSDKLHAQTELEARREQSPQDAGGSGRNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUC7</accession>
    <name>B8DUC7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_1319</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0749 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217982.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1319"/>
    <dbReference type="EnsemblBacteria" id="ACL29606">
        <property type="protein sequence ID" value="ACL29606"/>
        <property type="gene ID" value="BLA_1319"/>
    </dbReference>
    <dbReference type="GeneID" id="66533144"/>
    <dbReference type="KEGG" id="bla:BLA_1319"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1381"/>
    <dbReference type="HOGENOM" id="CLU_040273_0_2_11"/>
    <dbReference type="OMA" id="GLWPPRV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010273">
        <property type="entry name" value="DUF881"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37313">
        <property type="entry name" value="PTHR37313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05949">
        <property type="entry name" value="DUF881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="104"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="292" mass="31338" checksum="04DE6BDB477AEB00" modified="2009-03-03" version="1">MGEANGHENKPIQSAGTPPEPPSGIHVKKILSQQKKDRQNDKLPTGAFPAVRKAKPKKQISGRAQSIRARLLASVLVAALCALLSFGYVIQVNNTDMTYETMTESELTRMLGETNTQVQRLEERRTELSRQLTSLQQAADKEAEANRIAKENEESSGILSGRLPAEGPGIIVHISAGTKAPIDAATMFNLIEELRNGGAEVIAINDVRVVTSTYISEGANGLICDGKALNAPYIVKAIGEQNNLANAVNMAGGVGSRLTVKFGASVNVETSDDVKITQTQPVTNYKYAKIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUD1</accession>
    <name>B8DUD1_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">crcB</name>
        <name evidence="10" type="ordered locus">BLA_1323</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217977.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29610">
        <property type="protein sequence ID" value="ACL29610"/>
        <property type="gene ID" value="BLA_1323"/>
    </dbReference>
    <dbReference type="GeneID" id="66533148"/>
    <dbReference type="KEGG" id="bla:BLA_1323"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1385"/>
    <dbReference type="HOGENOM" id="CLU_114342_2_1_11"/>
    <dbReference type="OMA" id="FLMFESF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00494">
        <property type="entry name" value="crcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL29610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="125" mass="13125" checksum="1D24A6492FA0BB47" modified="2009-03-03" version="1">MIWPNLSAVAVGAFAGGCLRSLASGWLNRKDYAIPCGTLLVNLAGSLLVGIMLGVVAMGSVAEPWKALLITGFCGGLTTFSTFTSEVVSLFEEHSTVRAWIYWIGSVVAGICCVAFGFLVTRAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUD5</accession>
    <name>B8DUD5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_1327</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1327"/>
    <dbReference type="EnsemblBacteria" id="ACL29614">
        <property type="protein sequence ID" value="ACL29614"/>
        <property type="gene ID" value="BLA_1327"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1327"/>
    <dbReference type="HOGENOM" id="CLU_002902_4_1_11"/>
    <dbReference type="OMA" id="ECHYMND"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="70"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="323"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="875" mass="99625" checksum="853A2AEA2712BA19" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUE2</accession>
    <name>B8DUE2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1336"/>
    <dbReference type="EnsemblBacteria" id="ACL29621">
        <property type="protein sequence ID" value="ACL29621"/>
        <property type="gene ID" value="BLA_1336"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1336"/>
    <dbReference type="HOGENOM" id="CLU_038559_0_0_11"/>
    <dbReference type="OMA" id="FACRPLN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045931">
        <property type="entry name" value="DUF6350"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19877">
        <property type="entry name" value="DUF6350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="415" mass="45657" checksum="C26996ADC8148B70" modified="2009-03-03" version="1">MEEGGETMSSFAVPLTRVIVLLSQGIGMHAGAITLTITPLLLTLAMILLIRAVYSHWSTDLPAYLAGVATWIVLCLWCSGETRIQLTDSIWLIALKCAVVFSLGFAWRALPGSALMDRGRLYCREHISQPVRSSIHVGVRLALRLLVIFLSIGLITVFVWICLDHSSMVTMFKTMHMNTGSRILMCIMALAWLPNMALWALSWVFGGGFHIGQAASYSLWSAQIHELPSLPIFALFPHPVDNAGIRTCLMLIPVMLGFVFGLLMLLLHRGFHVRGIDPNEPVDVRDLLLRFAYPAGAFCITATLVSLMSSLAFWLANGSLGVGRLRDVGVDVMRSTNVVARPCAIGLGISWISAIVIVAIHSLMLMMLKRRAANRTSLPLESADSPDDERKEHKTPHTPRVVNSTFTQKETKGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUF8</accession>
    <name>B8DUF8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1352"/>
    <dbReference type="EnsemblBacteria" id="ACL29637">
        <property type="protein sequence ID" value="ACL29637"/>
        <property type="gene ID" value="BLA_1352"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1352"/>
    <dbReference type="HOGENOM" id="CLU_055821_1_0_11"/>
    <dbReference type="OMA" id="IEPNMRW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008492">
        <property type="entry name" value="DUF774"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028754">
        <property type="entry name" value="UCP028754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="277" mass="31393" checksum="AF3E10DC3BB48D28" modified="2009-03-03" version="1">MNERGTRVKYVMVAAFDGWNDACQSATDVIRHLVSRYRSLEIGHINKDGYYDYQSARPMQCTIQGSRCILWPQTVFYDIAVSDSLHILAQLGPEPNYQWLEYCRGSLRFAEQYDVECIVTLGSMLAECPHTRPLPIDISNNGKPLDPDYEYNGPIGITHALDMMAIEQGFNTTSLWVSIPRYLGSADPCPQATLTLLRELGEILGLDLPAGTIENKAKQWRSRCDVTVRNNVDFEHFVSQLERDYDLHQHAKELSSAGTPMAEQLVQEAEAFLRDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUH2</accession>
    <name>B8DUH2_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="2 7">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pgk</name>
        <name evidence="9" type="ordered locus">BLA_1366</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="2 7"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1366"/>
    <dbReference type="EnsemblBacteria" id="ACL29651">
        <property type="protein sequence ID" value="ACL29651"/>
        <property type="gene ID" value="BLA_1366"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1366"/>
    <dbReference type="HOGENOM" id="CLU_025427_1_0_11"/>
    <dbReference type="OMA" id="YVNDAYS"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL29651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="259" mass="27030" checksum="79920E1E4A5C52BF" modified="2009-03-03" version="1">MFVSDGFGVVHRAQGSDYDVAADLPAAAGLLVEKEVNALSKATEDPERPFTVVLGGSKVSDKLGVIENLLDKADRLVIGGGMVFTFLKAKGYEVGTSLLEEDMIDQVKGYIETADKNGVELVLPVDIVVNKGFPAGDTPVDPKVVPADQIPSDMMGLDIGPESCKLFHDKIVDSKTVVWNGPMGVFEVPAFAAGTKAVAQALVDATEHGAFTIVGGGDSAAAVRQLGFPEDGFSHISTGGGASLEFLEGKELPGLKVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUH5</accession>
    <name>B8DUH5_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Shikimate dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="3">1.1.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">aroE</name>
        <name evidence="6" type="ordered locus">BLA_1369</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.25" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217919.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1369"/>
    <dbReference type="EnsemblBacteria" id="ACL29654">
        <property type="protein sequence ID" value="ACL29654"/>
        <property type="gene ID" value="BLA_1369"/>
    </dbReference>
    <dbReference type="GeneID" id="66533200"/>
    <dbReference type="KEGG" id="bla:BLA_1369"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1433"/>
    <dbReference type="HOGENOM" id="CLU_044063_0_0_11"/>
    <dbReference type="OMA" id="FGNPIKH"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="5">
        <location>
            <begin position="9"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="4">
        <location>
            <begin position="138"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="308" mass="33069" checksum="B95F27716ABC5553" modified="2009-03-03" version="1">MNEMQRCAVLGKPIAHSLSPVLHEAAYRALGLGQWSYTKQEVAESELPSFLASLDPSWRGLSLTMPLKRTIAPFGIARNQWARELGVANTVVFDWDSPSTSAGRDLPAMALYNTDVYGIVRAFHDAFRTHVMTLPAQPHAVILGNGNTATSALAACITMGCSQITVAARHPNRSTALIELGAAHGVTVRSISLEDCLPALEQCNIAISTIPGTGADVVARHFAEHAQPIHGALLDVVYDPRPTELMVAWRDRGGLTIGGERMLLHQAVAQVLLMTGIIGGADVDDALNNPPQTGTLEQAMWEALEKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUK1</accession>
    <name>B8DUK1_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aspartate carbamoyltransferase regulatory chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pyrI</name>
        <name evidence="9" type="ordered locus">BLA_1395</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in allosteric regulation of aspartate carbamoyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PyrI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217887.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1395"/>
    <dbReference type="EnsemblBacteria" id="ACL29680">
        <property type="protein sequence ID" value="ACL29680"/>
        <property type="gene ID" value="BLA_1395"/>
    </dbReference>
    <dbReference type="GeneID" id="66533225"/>
    <dbReference type="KEGG" id="bla:BLA_1395"/>
    <dbReference type="HOGENOM" id="CLU_128576_0_0_11"/>
    <dbReference type="OMA" id="CPNRNCI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009347">
        <property type="term" value="C:aspartate carbamoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020545">
        <property type="entry name" value="Asp_carbamoyltransf_reg_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002801">
        <property type="entry name" value="Asp_carbamoylTrfase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020542">
        <property type="entry name" value="Asp_carbamoyltrfase_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036792">
        <property type="entry name" value="Asp_carbatrfase_reg_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036793">
        <property type="entry name" value="Asp_carbatrfase_reg_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35805">
        <property type="entry name" value="PTHR35805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01948">
        <property type="entry name" value="PyrI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02748">
        <property type="entry name" value="PyrI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54893">
        <property type="entry name" value="SSF54893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57825">
        <property type="entry name" value="SSF57825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PyrI" evidence="7">
        <location>
            <begin position="2"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="PyrI_C" evidence="8">
        <location>
            <begin position="94"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL29680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="139" mass="15533" checksum="DD4E1AF9FCE6E462" modified="2009-03-03" version="1">MEVTSIQDGIIIDHVPAGTALKVLEYLRIDPATTKLALIMNTTSRRYGSKDIIKIEDAQDVDLDVLGLVARQATVDIIHGGQIVNKQTPTLPERVVNVITCVNPRCVTTTEPGIDQVFYLDHTDDEVYRCRYCDEEAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUK5</accession>
    <name>B8DUK5_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methylenetetrahydrofolate reductase</fullName>
            <ecNumber evidence="10">1.5.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">metF</name>
        <name evidence="11" type="ordered locus">BLA_1399</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19821"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19817"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.20" evidence="10"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269093.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1399"/>
    <dbReference type="EnsemblBacteria" id="ACL29684">
        <property type="protein sequence ID" value="ACL29684"/>
        <property type="gene ID" value="BLA_1399"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1399"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1463"/>
    <dbReference type="HOGENOM" id="CLU_025841_0_2_11"/>
    <dbReference type="OMA" id="EMHPQAR"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106312">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106313">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADPH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004620">
        <property type="entry name" value="MTHF_reductase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00676">
        <property type="entry name" value="fadh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0274">FAD</keyword>
    <keyword evidence="6 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL29684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="281" mass="31084" checksum="316C56E085FDC26F" modified="2009-03-03" version="1">MHTPMFSLEVFPPKRTSPVGTIYDTLDGLNDMKPDFISVTYGTGKSADRTATARIAHTIHSEYGIDAVAHLTAQYLTARDVDEALAMFDEAKVSGVLALRGDRNSEREPAGVFTHASDLVCYIRERRPNLKIYGACYPEKHPQAATLDEDVANLKAKVDAGASHLISQLFYDDDFIAFLGKARAAGIDVPIEAGIMPVTNAKSVRRMTNMCSSRVPRKLERMLEKWGDDPRTLREAGIIYASEQISDLVAQGVDGVHLYTMNHPSVSRRIWQNVGNLFEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUS3</accession>
    <name>B8DUS3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_1470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217792.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1470"/>
    <dbReference type="EnsemblBacteria" id="ACL29752">
        <property type="protein sequence ID" value="ACL29752"/>
        <property type="gene ID" value="BLA_1470"/>
    </dbReference>
    <dbReference type="GeneID" id="66533300"/>
    <dbReference type="KEGG" id="bla:BLA_1470"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1538"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="YEDTDIH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="292" mass="32787" checksum="C42DAC53F4A485C1" modified="2009-03-03" version="1">MKIALDHVTKHYPDFDLDVTMEVPDDTITALIGTNGSGKTTTFRLMLGLARPAGGEGIILGDPIRRVWVNAKSRTGVTFGDSTFVPTFTLNDEIAERKRFYTTFDEQWCRAQLQRFTLPLNQQIQEFSAGMLAECKTIMAMAHHPEPLILDEPTAGLDVIARNEVLDLLREYMEIPGRSMLISSHVATDLENLCDDLYLIDRGRIRMHETIDALHDEYAVLTLTDDQMSAADPRYILVKQRTAGGWKAITDERGFYEENLPGVGICGASIDEIITLMSADPRTTTMQERTMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUW2</accession>
    <name>B8DUW2_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphomannomutase</fullName>
            <ecNumber evidence="5">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BLA_1509</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1509"/>
    <dbReference type="EnsemblBacteria" id="ACL29791">
        <property type="protein sequence ID" value="ACL29791"/>
        <property type="gene ID" value="BLA_1509"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1509"/>
    <dbReference type="HOGENOM" id="CLU_065090_0_0_11"/>
    <dbReference type="OMA" id="GDWPQFQ"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043169">
        <property type="entry name" value="PMM_cap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PTHR10466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="253" mass="28384" checksum="87D286D336FA2C44" modified="2009-03-03" version="1">MKVMAFDLDGTLARSKKPMHKPMADALSQLTRLLPVAIISGGTIDLVRSQVTDMLSDEADRSHMHLMPTSGARYYRWNPEDDDWQEAYEHNLSEEDRRLVIESLERHARELGIWQARTWGPRIEDRGSQITFSALGQQAPVEAKEEWDPTNEKKNRLAEAVQKDVPHLAVRSGGSTSVDISNRGVDKAYAVRKLADMLGVTVGQIAFVGDRMDPDGNDYPAALAGTIAIRVTGPEDTLQLCNRIIDWYNRNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUX4</accession>
    <name>B8DUX4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar permease of ABC transporter system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">msmF</name>
        <name evidence="7" type="ordered locus">BLA_1521</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1521"/>
    <dbReference type="EnsemblBacteria" id="ACL29803">
        <property type="protein sequence ID" value="ACL29803"/>
        <property type="gene ID" value="BLA_1521"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1521"/>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_11"/>
    <dbReference type="OMA" id="MSGTWLT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="93"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="314" mass="35186" checksum="1FF2063398C0550D" modified="2009-03-03" version="1">MLANDIDTHHSRTPAGKPPRKRRVSAFSRRKVDHAYYWMAVPAAVIFAVFLYVPFVRGIMYSFTNSQGYGSCNWIGFQNYFALFRDERVGHAYLFTFLIAIAITVLINVIALFLSVALNGKIACKNGFRAIYFIPYTLAVLVIGYVFKYIFMQPLPELGKALGIGWLSESLLTSERYAWIPIVFLAVWQGVAYSVLIYLAGLQTVDSEVYEAAAIDGVNAWQKFWKITFPLIGPFFTINLVLTMKNALGTFDQVVALTDGGPNSKTETVTYLIWKGGLTGGEYAYQTANAVLFFIVLAIIAFIQLKFFGSKEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUZ4</accession>
    <name>B8DUZ4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA adenylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.72</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_1541</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.72" evidence="4"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268865.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1541"/>
    <dbReference type="EnsemblBacteria" id="ACL29823">
        <property type="protein sequence ID" value="ACL29823"/>
        <property type="gene ID" value="BLA_1541"/>
    </dbReference>
    <dbReference type="GeneID" id="66533939"/>
    <dbReference type="KEGG" id="bla:BLA_1541"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1619"/>
    <dbReference type="HOGENOM" id="CLU_015961_6_1_11"/>
    <dbReference type="OMA" id="HRHKDVY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052928">
        <property type="term" value="F:CTP:3'-cytidine-tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CTP:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016437">
        <property type="term" value="F:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014065">
        <property type="entry name" value="tRNA_adenylyltransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02692">
        <property type="entry name" value="tRNA_CCA_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HDc" evidence="3">
        <location>
            <begin position="251"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="472" mass="53604" checksum="C4EDB7C256E8A600" modified="2009-03-03" version="1">MNFEVWPEAIELGQMFADEGFELALVGGPVRDLLLHRRSHDLDFCSNARPEQFEPILRRFGHDGFWDMGRKFGTLGAMRRRPDGTEVKVEVTTYRSDVYDPDSRKPEVSYGDSLEGDLSRRDFTVNAMALTVPDLEFVDPFGGANDLNKRVLRTPVDPYQSFDDDPLRMMRAVRFVAQLGFSIEPETAEAITRMTDRIEIVSAERVRDELTKLLLSDRPRAGIEALVDSGLADVVLPEIPALRLEIDEHHRHKDVFDHTMIVVDRAVALETGPDGPVPAPDLVLRLAALMHDIGKPKTRRFEPGGKVSFHHHDAVGAKMTRKRLKALRFDHHVVEQVSDLVDLHLRFHGYVDEPWTDAAVRRYVKDAGPLYARLNRLTRADATTQNRRKALMFEHAMDEMEERVAKLKEQEDIDAIRPDLNGDEIMAELGIAPGPLVGKAYRHMLEYRLDNGPVDHDTAVAELHNWYASQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV14</accession>
    <name>B8DV14_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Predicted membrane protein, hemolysin III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BLA_0009</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28315">
        <property type="protein sequence ID" value="ACL28315"/>
        <property type="gene ID" value="BLA_0009"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0009"/>
    <dbReference type="HOGENOM" id="CLU_051078_2_2_11"/>
    <dbReference type="OMA" id="YHRRVWS"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="PTHR20855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL28315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="287" mass="32424" checksum="C8A6727B6117178E" modified="2009-03-03" version="1">MANRRANPSQRKPPRSSYLEDSRMKRNNRHIGQVTRSQKPRKVVTAKKLRAQSKRNEQYRTKMQLRQILLEKPKLRGWLHLIAFPFSVATSVILICLAPSGWMKVAISVYSATIILLFGNSAALHLGHGYFPKAVDDVLCRIDYSNIFLVIAGTCTPFFFALNNTVICWVYVGVVWVTALLGTFVHLIYPVGLDWLFTIVYIVLGLAPITIIWLFWKSPYIGPVPTILVIAGGACYIAGAVCFALRKPNPFPKWFGFHELFHLGTIGGYVCHVIALFMVVLRMRALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV15</accession>
    <name>B8DV15_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gdhA</name>
        <name evidence="9" type="ordered locus">BLA_0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 7">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219034.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0010"/>
    <dbReference type="EnsemblBacteria" id="ACL28316">
        <property type="protein sequence ID" value="ACL28316"/>
        <property type="gene ID" value="BLA_0010"/>
    </dbReference>
    <dbReference type="GeneID" id="66532383"/>
    <dbReference type="KEGG" id="bla:BLA_0010"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.10"/>
    <dbReference type="HOGENOM" id="CLU_025763_2_1_11"/>
    <dbReference type="OMA" id="PCFAAFP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004353">
        <property type="term" value="F:glutamate dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="8">
        <location>
            <begin position="204"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="6">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL28316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="448" mass="49030" checksum="6B11FE596E919381" modified="2009-03-03" version="1">MLTDEYVKRVYAQVEARDPDQSEFLQAVQEVFESIEPVFAKHPEYEAAGVLQRFVEPERLVKFRVAWADDNGDVQVNRGYRVQFNSAIGPYKGGLRFHPTVTESVIKFLGFEQILKNSLTGLPMGGGKGGSDFDPKGRSDAEVMRFCQAFMTELQRHIGQFTDVPAGDINVGAREVGYLFGQYKRLRNEFAGVLTGKGLEFGGSLARTEATGYGLCYYTQEALRVLRDDSFEGKTVVVSGSGNVAIFAIEKATQLGAKVVTCSDSNGYVYDPNGIDLDVVKDIKLNKRGRIREYADRVDGAEYHEGCREVWTVPCDIALPCATQNEIDGESAQKLVDNGCTVVCEGANMPSTPQAIEVYQKNHVLYGPAKAANAGGVAVSGLEMSQNSYRLSWSFEKVDEELKGIMKNIVAESLDAAKEYGHDGDLMFGANVAGFTKVANAMVAQGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV35</accession>
    <name>B8DV35_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28336">
        <property type="protein sequence ID" value="ACL28336"/>
        <property type="gene ID" value="BLA_0031"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0031"/>
    <dbReference type="HOGENOM" id="CLU_1425482_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="206" mass="22698" checksum="819AD3786C7874C7" modified="2009-03-03" version="1">MRLNSPHSSTGLTMVRRLVDVMAHDLGVPRRASDDPDGEALACRCTFTALRFWMQAYCIDDGYGGAAGIAQTAVEQKSLAWIKQMSALYPQLRSKFTPALIHQYCSALTAIGDLAETSEGMLRCTKPHDLRIPYSGGTFVIAQLGLRDLTVQDWEGCVLSDAVVFAGVSKHNGIVGFDPDMIGWELPYRDELLFLAKWQEASNALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV43</accession>
    <name>B8DV43_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4234 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0041"/>
    <dbReference type="EnsemblBacteria" id="ACL28344">
        <property type="protein sequence ID" value="ACL28344"/>
        <property type="gene ID" value="BLA_0041"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0041"/>
    <dbReference type="HOGENOM" id="CLU_094908_1_0_11"/>
    <dbReference type="OMA" id="YCLMFFL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025328">
        <property type="entry name" value="DUF4234"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14018">
        <property type="entry name" value="DUF4234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4234" evidence="2">
        <location>
            <begin position="25"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="150" mass="17130" checksum="B43E4483D193C442" modified="2009-03-03" version="1">MQGTPMPAPPVQQMRPNAYRLPTNRSLTKFILLGLITFGIYDIVIMTTTAEALNTIASPRDGKKTMNYCLMYFLIGWLTLGIGWLVWFHNFSDRIGEEQRRRGMVPTVTASTFWLWEVLGSLIVVGPFIYHYKMLHAMNDLCASYNAYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV45</accession>
    <name>B8DV45_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase family 30 protein</fullName>
            <ecNumber evidence="7">3.2.1.45</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BLA_0043</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.45" evidence="7"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268914.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0043"/>
    <dbReference type="CAZy" id="GH30">
        <property type="family name" value="Glycoside Hydrolase Family 30"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28346">
        <property type="protein sequence ID" value="ACL28346"/>
        <property type="gene ID" value="BLA_0043"/>
    </dbReference>
    <dbReference type="GeneID" id="66532419"/>
    <dbReference type="KEGG" id="bla:BLA_0043"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.47"/>
    <dbReference type="HOGENOM" id="CLU_014379_1_1_11"/>
    <dbReference type="OMA" id="WIDWNII"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="PTHR11069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00843">
        <property type="entry name" value="GLHYDRLASE30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glyco_hydro_30" evidence="5">
        <location>
            <begin position="55"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_30" evidence="5">
        <location>
            <begin position="370"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_30C" evidence="6">
        <location>
            <begin position="444"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL28346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="508" mass="56885" checksum="CE89CE289B01D4C7" modified="2009-03-03" version="1">MMKALKTTVHYDVTAGRTHTEQTELSVMDEAMNTEHIVESNVVGIYPDYTFQMMEGYGCSLTESACYLLSKMDSATRKEALAQWFGPAGMDAWFVRVHIDSCDYSLSEYQAVEDPLADPELETFSIDRDRQYILPVLKEAMAMAGHPIHVLLSPWSPPAQWKTPPEMTRNDASVYGGEEGDVIDLSKPGRCFGGRLKPEYYSSWARYLVRFISAYMAEGVPVTMLSIQNEAAAATSWDSCLWTGDQEREFLKHHLYPAMEEAGLTDAVKIFIWDHNKERAIEHIDEFMSDPEAAKEVGGFAYHWYSGDHFEALSMLRGKYPDKVLMHSESCGLHIPGKVTMLDMTDEQIEALPDGDYKTMVQTTTPNEMDFNDATAYAHDIIGDLNHGMQRWIDWNMIVDRQGGPRHTPGGFAAPIVAEDDGRYTLTISYRYIREIAQAIKPNAVVLGTSTYSRDIEAVSARNADGSIGVVLLNQAERDIPVNIRMGGLLVADVPLPARTLSTLVFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV66</accession>
    <name>B8DV66_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619621.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0064"/>
    <dbReference type="EnsemblBacteria" id="ACL28367">
        <property type="protein sequence ID" value="ACL28367"/>
        <property type="gene ID" value="BLA_0064"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0064"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.69"/>
    <dbReference type="HOGENOM" id="CLU_161187_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021426">
        <property type="entry name" value="DUF3073"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11273">
        <property type="entry name" value="DUF3073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="115" mass="12914" checksum="14D5FAC3D0ADE8C7" modified="2009-03-03" version="1">MGRGRQKAKQQKIARKLKYMTTDTDYDELAKELGAHEPGTGSFDPFADVENDEFQAQDVDETVDDLDEYAKWAAEAAAKATTGEMPETHAQPKPKPHKPIPMPVPETFKHTDQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV67</accession>
    <name>B8DV67_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619622.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0065"/>
    <dbReference type="EnsemblBacteria" id="ACL28368">
        <property type="protein sequence ID" value="ACL28368"/>
        <property type="gene ID" value="BLA_0065"/>
    </dbReference>
    <dbReference type="GeneID" id="66532441"/>
    <dbReference type="KEGG" id="bla:BLA_0065"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.70"/>
    <dbReference type="HOGENOM" id="CLU_123202_0_0_11"/>
    <dbReference type="OMA" id="ETDAATW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041629">
        <property type="entry name" value="SCP_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17844">
        <property type="entry name" value="SCP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SCP_3" evidence="1">
        <location>
            <begin position="40"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="135" mass="14709" checksum="C8BCA6EFA3B50212" modified="2009-03-03" version="1">MAAIRKQDMMRGMQAYDDWCTAARAAAETTPALDIAPRLDRATMAMAVRYSLHQLEIKAPGPGVEVRVAPYAVVKILEGPASDPHNLTPPDVIELDPQVWLRVASGITTWHEEQKAGRISAVGERDDLSPLLPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV75</accession>
    <name>B8DV75_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sortase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0073</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218365.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0073"/>
    <dbReference type="EnsemblBacteria" id="ACL28376">
        <property type="protein sequence ID" value="ACL28376"/>
        <property type="gene ID" value="BLA_0073"/>
    </dbReference>
    <dbReference type="GeneID" id="66532448"/>
    <dbReference type="KEGG" id="bla:BLA_0073"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.77"/>
    <dbReference type="HOGENOM" id="CLU_713501_0_0_11"/>
    <dbReference type="OMA" id="MRHGRHN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05830">
        <property type="entry name" value="Sortase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042003">
        <property type="entry name" value="Sortase_E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="384" mass="42698" checksum="3BECBBA5E303910F" modified="2009-03-03" version="1">MKHGGRRGNASARQDGRIDRLPEVGGKRSVMRSVVMILAEILLTVGLVCALYVVWMQWWTGVQSENRQIEERQSVGWAQPASDGANAKIAHPQQGDPPLQPEHASIGELIGRVYIPRFGDAWERNLVQGTDLAELNLHGLGHYVDSQMPGQVGNFAIAGHRNGYGQPLGDVDKLQPGDAVVVRTKDYWYVYTYTNYTIVTPDETSVISANPEDPSAPPTKRLLTMTTCEPKYTAPTHRWISFGEFKYWAKVSDGVPAELAKKGADGATKFISNEQTPFFAKLKTLQPVIWGALIAYAIIFIAAAIAWRWPLLRAIREGRRPRPDVDIYGVLVRHQPGPAPIRWLLALLLFVAVSLAIIEWACPWAASHIEILREMSNYTAVNTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV76</accession>
    <name>B8DV76_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Para-aminobenzoate synthase glutamine amidotransferase component II</fullName>
            <ecNumber evidence="2">2.6.1.85</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pabA</name>
        <name evidence="2" type="ordered locus">BLA_0074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.6.1.85" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218366.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0074"/>
    <dbReference type="MEROPS" id="C26.955"/>
    <dbReference type="EnsemblBacteria" id="ACL28377">
        <property type="protein sequence ID" value="ACL28377"/>
        <property type="gene ID" value="BLA_0074"/>
    </dbReference>
    <dbReference type="GeneID" id="66532449"/>
    <dbReference type="KEGG" id="bla:BLA_0074"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.79"/>
    <dbReference type="HOGENOM" id="CLU_014340_1_2_11"/>
    <dbReference type="OMA" id="TEHGHAM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="215" mass="23170" checksum="7372F0A40E10237E" modified="2009-03-03" version="1">MTDSARILVIDNYDSFVYTIVGYLKTLGATVTVVRNDALDPHEDGVLDDYDGVLISPGPGAPSESGVSEDVIRLCAQTGTPMFGVCLGMQALAEVYGCTVSHAPTIMHGKTSLVEHVDDEIFAGVANPMTATRYHSLAAEPDSVPDELQVTAWTVDDHIVQGIRHRELPLFAVQFHPESVLTQDGYRLFANWLAVCGQESAVEKSLGLQPKLAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV87</accession>
    <name>B8DV87_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218382.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28388">
        <property type="protein sequence ID" value="ACL28388"/>
        <property type="gene ID" value="BLA_0085"/>
    </dbReference>
    <dbReference type="GeneID" id="66532460"/>
    <dbReference type="KEGG" id="bla:BLA_0085"/>
    <dbReference type="HOGENOM" id="CLU_2140979_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="112" mass="12926" checksum="7F9D6371F3B372FA" modified="2009-03-03" version="1">MVAQNIIMTVLNVIVLVALLVFGVYAVYNNKPNFELTPAHLYDQQMGQKYGIWVFICVIISWLVTLPGLFGPLSNTWNQILWWVELIFNIATLVFCVLASFYYSRLNTRPHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVB3</accession>
    <name>B8DVB3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase</fullName>
            <ecNumber evidence="3">1.14.13.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.14.13.25" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218409.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28414">
        <property type="protein sequence ID" value="ACL28414"/>
        <property type="gene ID" value="BLA_0111"/>
    </dbReference>
    <dbReference type="GeneID" id="66532486"/>
    <dbReference type="KEGG" id="bla:BLA_0111"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.115"/>
    <dbReference type="HOGENOM" id="CLU_003827_19_3_11"/>
    <dbReference type="OMA" id="LTSWHRW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106317">
        <property type="term" value="F:methane monooxygenase NADH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106318">
        <property type="term" value="F:methane monooxygenase NADPH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="2">
        <location>
            <begin position="210"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="431" mass="48564" checksum="40AD64AC8E4B003C" modified="2009-03-03" version="1">MKRIAIRRFPIQAVLVWAAALVVVPMPFTAIPWATLGPMYRSMLTPITAGIYAYIWMLECVWLGCRPRWLDRIIGLPGIYVLHGVLGTGALALVVYHQYVLPSFGPAKTTGEIAFWTLVGIVALALVMMAGWLDTLVPPLATVRSWLERVFRHEFTVWLHRIVLVAVVLACLHFNLVFYIKDLTAFIVTMDVTTGLVLAWYAWVKLRDRMFAARGKVVSARRVSNDIVEILVDCPAMHSWEYGDFVFLRLPRERGMHGSHPFSIANLPGEHGDAMRFAVRINGDFTERLYRTARAGMRVDVIGPFGMYERFIARHDAHAPIVVYAGGVGITPIIPTIMALSGTNRPVTVMYTAKRADDLLYADELRKWSASEAHTPHMQVGRWSKTELAEQITDGAIYLIAGPSGMIRDVRRMLLRHGVPGSRMFYEPFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVD0</accession>
    <name>B8DVD0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sucrose operon repressor ScrR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">scrR</name>
        <name evidence="5" type="ordered locus">BLA_0128</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218427.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0128"/>
    <dbReference type="EnsemblBacteria" id="ACL28431">
        <property type="protein sequence ID" value="ACL28431"/>
        <property type="gene ID" value="BLA_0128"/>
    </dbReference>
    <dbReference type="GeneID" id="66532503"/>
    <dbReference type="KEGG" id="bla:BLA_0128"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.134"/>
    <dbReference type="HOGENOM" id="CLU_037628_14_2_11"/>
    <dbReference type="OMA" id="MILCNSN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="342" mass="37273" checksum="21B967FE9D2FAE53" modified="2009-03-03" version="1">MVGMRDVAKRAGVSVSSVSLVINGTGYVSRDMREKVEQAMRELDYVPNELARNFYHGKTDIIGVIVPTIQHPFFATLTAHLQHEFADRGLQTMLCSTADSANGEAQYVDMLRRHSLDALVVAAHTTHDPQYWRAIDRPVVAFDRNLGAGITQVSSDHVHGGELIAELLVRTGAHHVVMVGGPRAQFTDLGDHSTFPTVRYVQTLEDRLSQARIAHTYIESGEVFDIAGVRRAVREAFDTYPDMDAFVGADLAAAFAVQEAVSRSIAVPGDVQIIAYDGTLAADCAGMPLTTVAQDFRQIAHTIAACVEHGIESSPQRPDATDGDANMTIIPVTLHERATTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVH3</accession>
    <name>B8DVH3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Patatin-like phospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0172</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0172"/>
    <dbReference type="EnsemblBacteria" id="ACL28474">
        <property type="protein sequence ID" value="ACL28474"/>
        <property type="gene ID" value="BLA_0172"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0172"/>
    <dbReference type="HOGENOM" id="CLU_048271_1_0_11"/>
    <dbReference type="OMA" id="YPHRSIN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07208">
        <property type="entry name" value="Pat_hypo_Ecoli_yjju_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037483">
        <property type="entry name" value="YjjU-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="3"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="34"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="276" mass="30521" checksum="58712D55B05F4D70" modified="2009-03-03" version="1">MGVIDVGGGLRSAYSTGVLDYCLDNGIHFDYGLGVSAGAANITSYLAGQRGRPLRFYTKYCPRPEYMSLGNFLRDGSYLGLDYIYGTLMNEDGEDPLDYDALVAGGVPYRITVTDALSGMPKYLGPESMSRNHYDALKATACLPVLDKPYPLDGRPYFDGTISDPIPFRQAFADGCTKLVVILTRPRDFYRNPDKDIASSMMLAVRYPEAARALANRAHTYNVELNMCKRLEAQGKVRIIAPKSIDGVSTLTKDPDKIQNLYNRAYNDATALRNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVI1</accession>
    <name>B8DVI1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein-pII uridylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.59</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glnD</name>
        <name evidence="3" type="ordered locus">BLA_0180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.59" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0180"/>
    <dbReference type="EnsemblBacteria" id="ACL28482">
        <property type="protein sequence ID" value="ACL28482"/>
        <property type="gene ID" value="BLA_0180"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0180"/>
    <dbReference type="HOGENOM" id="CLU_012833_2_0_11"/>
    <dbReference type="OMA" id="WIAKYVY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008773">
        <property type="term" value="F:[protein-PII] uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013546">
        <property type="entry name" value="PII_UdlTrfase/GS_AdlTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010043">
        <property type="entry name" value="UTase/UR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47320">
        <property type="entry name" value="PTHR47320"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08335">
        <property type="entry name" value="GlnD_UR_UTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GlnD_UR_UTase" evidence="2">
        <location>
            <begin position="218"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="614" mass="67805" checksum="8FE65435897F4549" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVJ1</accession>
    <name>B8DVJ1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thymidine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218506.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0190"/>
    <dbReference type="EnsemblBacteria" id="ACL28492">
        <property type="protein sequence ID" value="ACL28492"/>
        <property type="gene ID" value="BLA_0190"/>
    </dbReference>
    <dbReference type="GeneID" id="66532565"/>
    <dbReference type="KEGG" id="bla:BLA_0190"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.199"/>
    <dbReference type="HOGENOM" id="CLU_087285_0_0_11"/>
    <dbReference type="OMA" id="WRLYALR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="241" mass="26156" checksum="B390C36934251E5A" modified="2009-03-03" version="1">MHSGSGSIIASRSAFTHTGSPRPARPGQLDQAIAEGLASDVDPERLREVAHTTAWALLSKVHKTDDPAIVERVLTLVDREGVDVIAELWSKAEPDSLPGVLWRLYLLRSWMRKQRDTIARLWRLGEPIATSASAIAGVDSAPTEDDIARTADSILTGAFRGDFAVALTRASVFVGIVALGLRVEARELTQQANLNPVGSAAEQSKRWRTQAAQLLHTAANLNITSKDFKHGAALWRQGKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVL6</accession>
    <name>B8DVL6_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dipeptidase</fullName>
            <ecNumber evidence="4">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pepD</name>
        <name evidence="5" type="ordered locus">BLA_0215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the peptidase C69 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219305.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="MEROPS" id="C69.001"/>
    <dbReference type="EnsemblBacteria" id="ACL28517">
        <property type="protein sequence ID" value="ACL28517"/>
        <property type="gene ID" value="BLA_0215"/>
    </dbReference>
    <dbReference type="GeneID" id="66532589"/>
    <dbReference type="KEGG" id="bla:BLA_0215"/>
    <dbReference type="HOGENOM" id="CLU_014823_4_1_11"/>
    <dbReference type="OMA" id="TAFVPYY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="PTHR12994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
        <property type="entry name" value="Peptidase_C69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="537" mass="59796" checksum="E64292FA0D50DBB0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVM5</accession>
    <name>B8DVM5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Permeases of the major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219295.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0224"/>
    <dbReference type="EnsemblBacteria" id="ACL28526">
        <property type="protein sequence ID" value="ACL28526"/>
        <property type="gene ID" value="BLA_0224"/>
    </dbReference>
    <dbReference type="GeneID" id="66532598"/>
    <dbReference type="KEGG" id="bla:BLA_0224"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.236"/>
    <dbReference type="HOGENOM" id="CLU_033532_0_1_11"/>
    <dbReference type="OMA" id="SVFGGMQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="472" mass="50555" checksum="F65E1E246533C41A" modified="2009-03-03" version="1">MSLLQGVKDVNHRIFGGYAELLRIPHAARFTVGSVIACMPFPMVGMTMTIMTQQYYGNYSLAGALTAVQAIAGAVVGPLLGTLVDRFGQRQVSIPTIVIWMLAAVSFVTCVRAQVTPWILFCIVPFFAAVPPWGAMSRARWTYLMGNDRAGVNRALSLSGVFDEAMWVVGNPLASTLAVISGFLAMSFTGICVLIGALMFLTEMTTCPPSQSDLAREAGVSRKEFREREAEKAKELRAQTAAEDARVHAKSQGLSDAEVEAAGKAAYERSMSGIKDSIWGPGLIAVCATWFGLGAFQSAAGISIIAFATEANMKQYTGFVFACFSISSLTGALLYGAKNWTIPLWKRFYVCLAVLNIGIGSFLFARHLWVIMVIYLIIGVCQSPTWINGNQLMLHLVPQTRFTEGMAWMGAMNSIGASAGSAVAGVFIDRAGSHGGFAVVTALAFVSLAIALLGFKQIKTSTETPVLTEISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVN8</accession>
    <name>B8DVN8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268325.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0237"/>
    <dbReference type="EnsemblBacteria" id="ACL28539">
        <property type="protein sequence ID" value="ACL28539"/>
        <property type="gene ID" value="BLA_0237"/>
    </dbReference>
    <dbReference type="GeneID" id="66532613"/>
    <dbReference type="KEGG" id="bla:BLA_0237"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.252"/>
    <dbReference type="HOGENOM" id="CLU_730890_0_0_11"/>
    <dbReference type="OMA" id="PEANQKY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032327">
        <property type="entry name" value="DUF4854"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16146">
        <property type="entry name" value="DUF4854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="378" mass="39489" checksum="59B35FDDC603D4F4" modified="2009-03-03" version="1">MTQPENPYTGGEQPAQPITPPADPYGLNPNANPNPYTQPQEPAQPYVQNAAPEQGREAYGNSNYGHAESAPQFTGNEPAQQPYGTPYEPVGTQPTTQINYGAPQNAAPQYGEQPAYGAPTGGAPVYGEPGGPAYGGPAQFPPQGGYDQYPPQGPTDKYNTMAIVGLILAILFPLIGLIVSIIAMVNINKHGGSKASKNLSLAGTIVGGVLTVVSIIVSIIVFNSVLAATNEIVSDSKSPSATHSQTQSTTDPDEDIDEDIDEDIDNDIDDIGGQLTGGSITLEEALKNPTVKSELEKQIQGLPDGMKGSVSAEGNTLILTFDLDSSLAEYSDSLAESLNSVGKSAASQLNEDGGNTYSVRIVITSEGKTLYDKTSTND</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVP6</accession>
    <name>B8DVP6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268340.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0245"/>
    <dbReference type="EnsemblBacteria" id="ACL28547">
        <property type="protein sequence ID" value="ACL28547"/>
        <property type="gene ID" value="BLA_0245"/>
    </dbReference>
    <dbReference type="GeneID" id="66532621"/>
    <dbReference type="KEGG" id="bla:BLA_0245"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.260"/>
    <dbReference type="HOGENOM" id="CLU_494933_0_0_11"/>
    <dbReference type="OMA" id="ARRCMPR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="550" mass="58792" checksum="12E651660D931399" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVR1</accession>
    <name>B8DVR1_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="11">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">cysS</name>
        <name evidence="14" type="ordered locus">BLA_0260</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="11"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268374.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0260"/>
    <dbReference type="EnsemblBacteria" id="ACL28562">
        <property type="protein sequence ID" value="ACL28562"/>
        <property type="gene ID" value="BLA_0260"/>
    </dbReference>
    <dbReference type="GeneID" id="66532635"/>
    <dbReference type="KEGG" id="bla:BLA_0260"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.276"/>
    <dbReference type="HOGENOM" id="CLU_013528_0_1_11"/>
    <dbReference type="OMA" id="AKYWMHN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DALR_2" evidence="13">
        <location>
            <begin position="409"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="209"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="11">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="11">
        <location>
            <begin position="325"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACL28562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="545" mass="59696" checksum="A49B7359844BA95F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVR4</accession>
    <name>B8DVR4_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetolactate synthase small subunit</fullName>
            <shortName evidence="8">AHAS</shortName>
            <shortName evidence="8">ALS</shortName>
            <ecNumber evidence="8">2.2.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid synthase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ilvN</name>
        <name evidence="10" type="ordered locus">BLA_0263</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 8">Dimer of large and small chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="8"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268377.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0263"/>
    <dbReference type="EnsemblBacteria" id="ACL28565">
        <property type="protein sequence ID" value="ACL28565"/>
        <property type="gene ID" value="BLA_0263"/>
    </dbReference>
    <dbReference type="GeneID" id="66532638"/>
    <dbReference type="KEGG" id="bla:BLA_0263"/>
    <dbReference type="HOGENOM" id="CLU_055003_1_3_11"/>
    <dbReference type="OMA" id="EPYGIKE"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30239">
        <property type="entry name" value="PTHR30239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="15"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL28565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="184" mass="19996" checksum="A4FF43809A6BA9E4" modified="2009-03-03" version="1">MASYPASKPGSQRHTLSVLVENRPGVLARIAGLFARRAFNINSLSVSPTERPDISRITVTADVEEVPLEQIIKQLNKLLHVLKIVDLDESTTVERELVLIKVAADQSNRSDVLEIVRLFRVRVVDVNPESLTIEATGAGGKIDALLGLLDHYGIIELVRSGAVAMTRGPRALSEKVVGSEITGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVS7</accession>
    <name>B8DVS7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FemAB-like protein possibly involved in interpeptide bridge formation in peptidoglycan</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FemABX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268400.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0276"/>
    <dbReference type="EnsemblBacteria" id="ACL28578">
        <property type="protein sequence ID" value="ACL28578"/>
        <property type="gene ID" value="BLA_0276"/>
    </dbReference>
    <dbReference type="GeneID" id="66532651"/>
    <dbReference type="KEGG" id="bla:BLA_0276"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.293"/>
    <dbReference type="HOGENOM" id="CLU_048411_1_0_11"/>
    <dbReference type="OMA" id="YNFLGIM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016755">
        <property type="term" value="F:aminoacyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044038">
        <property type="term" value="P:cell wall macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003447">
        <property type="entry name" value="FEMABX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02388">
        <property type="entry name" value="FemAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51191">
        <property type="entry name" value="FEMABX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="253"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="427" mass="48708" checksum="5034C00D2BD9AF26" modified="2009-03-03" version="1">MRKFSFEVLNEQEFRAFAEASPQSNFQQTVEMANLRRMHGMDVDFVGMREDGEIKAGAVFATHHAPMATFCSVISGPLCDYDDDELVAEFLRALARFAKKKGAVHLDIAPNQRYRVRDDHGEALPESEGGAPDKRMIRNIEQAGYEHGGFVRGYTSTVRWRFAKDMTGIGDESELLKSYSKRTQWSIKRARSMGVHVREIGVDELDTFARIEQQTAERRHFEFRGPQYFKQFAQCFGERARFVLAEIDTAEYQRSMQRKADDLRALVDGLEAKIAQRETTKLRRRLNEESSNLAAANKRLAEANELVEKGDLIPAAASMFVLGPREVVYLFSGSVEEYKPFYASALIQHEAMLRYCVQGVEPFGHVNLYDFYGIDGIFDDPDDEGRGVLEFKQGFNGYVVEMPGDFMKVLRPVTYRAQRLAHKLLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVS8</accession>
    <name>B8DVS8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268402.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0277"/>
    <dbReference type="EnsemblBacteria" id="ACL28579">
        <property type="protein sequence ID" value="ACL28579"/>
        <property type="gene ID" value="BLA_0277"/>
    </dbReference>
    <dbReference type="GeneID" id="66532652"/>
    <dbReference type="KEGG" id="bla:BLA_0277"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.294"/>
    <dbReference type="HOGENOM" id="CLU_056175_6_0_11"/>
    <dbReference type="OMA" id="HFSKFAF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="335" mass="36239" checksum="153AD3B3ED7E27AC" modified="2009-03-03" version="1">MTLLQPIALLAIIIAGYLFKRCRLFGQRDYRIIQVMLFDLVLPGAIVYSFATNPHDPSLLWLSAFGFVVALVPVLVIFSATRHSPVTQRAFLMLNATGLNIGCFCFPVVQAFLGEQAIVPAAMFDIGNCIMVAAGTNVMTQTLLHIQPGRPLTEQGAGDAPTLPYTRPTDRDAKRLARRSLLHTVLKGFVGSIPFDTYVIMIVLMVCGLSLPAWFADLFRPLSNANACVAMLMVGMMMDLPANRSDTFAVLKVLAWRLPFGLAFAAVAWFLLPFDAGIREATMMCCLAPVAVFSTLFTDEVLGNARLAGFTLSVSAVISLGMMTGAHAMIAAGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVU8</accession>
    <name>B8DVU8_BIFA0</name>
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        <submittedName>
            <fullName evidence="2">Putative regulator of polyketide synthase expression</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268439.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0297"/>
    <dbReference type="EnsemblBacteria" id="ACL28599">
        <property type="protein sequence ID" value="ACL28599"/>
        <property type="gene ID" value="BLA_0297"/>
    </dbReference>
    <dbReference type="GeneID" id="66532675"/>
    <dbReference type="KEGG" id="bla:BLA_0297"/>
    <dbReference type="HOGENOM" id="CLU_052484_1_0_11"/>
    <dbReference type="OMA" id="FECLFNH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="199"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="263" mass="28494" checksum="F66BBD4AD1FD7576" modified="2009-03-03" version="1">MTKFEHADILDLLGGDIDDNAVMRLVFECLISGIDDDRVVSLMNLIGWRGSFSCFALGGTPADSMGATFTQISSAVRDFGGSHAIFGMYGRFVIACIELEAAVSPEIVCTAALPAFAQSEAVYLSPVREGVPGASHAVRETLFSLQAAPSLSTQSRPLRADELLPERALLGDEVAREELYRNVYLVLHGDNEDDPSYITVSTFLRHGGSLEATAKELNVHPNTVRYRLKKAAETTGWDATNPRDAFVLNTAIALGRMREAGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVX0</accession>
    <name>B8DVX0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Large Ala/Glu-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268488.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0319"/>
    <dbReference type="EnsemblBacteria" id="ACL28621">
        <property type="protein sequence ID" value="ACL28621"/>
        <property type="gene ID" value="BLA_0319"/>
    </dbReference>
    <dbReference type="GeneID" id="66532698"/>
    <dbReference type="KEGG" id="bla:BLA_0319"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.342"/>
    <dbReference type="HOGENOM" id="CLU_034275_0_0_11"/>
    <dbReference type="OMA" id="QVSKMMT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="177"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="572" mass="62048" checksum="2EF8D55B7BE794ED" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVZ0</accession>
    <name>B8DVZ0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative regulatory protein, FmdB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268527.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0339"/>
    <dbReference type="EnsemblBacteria" id="ACL28641">
        <property type="protein sequence ID" value="ACL28641"/>
        <property type="gene ID" value="BLA_0339"/>
    </dbReference>
    <dbReference type="GeneID" id="66532718"/>
    <dbReference type="KEGG" id="bla:BLA_0339"/>
    <dbReference type="HOGENOM" id="CLU_136025_3_3_11"/>
    <dbReference type="OMA" id="TYLYECE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="63" mass="7169" checksum="404F9D4FCE161873" modified="2009-03-03" version="1">MPIYHYRCKKCGYDFTKEQSFSDDPIKVCPQCGAEQVHKVYAAVPITFKGSGFYRTDSHSSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW49</accession>
    <name>B8DW49_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1713 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268639.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28700">
        <property type="protein sequence ID" value="ACL28700"/>
        <property type="gene ID" value="BLA_0398"/>
    </dbReference>
    <dbReference type="GeneID" id="63994161"/>
    <dbReference type="GeneID" id="66533958"/>
    <dbReference type="KEGG" id="bla:BLA_0398"/>
    <dbReference type="HOGENOM" id="CLU_209136_2_1_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="COX24_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1713" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="29" mass="3701" checksum="E65291E68967862B" modified="2009-03-03" version="1">MGSVIKKRRKRMSKKKHRKLLRKTRHQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW53</accession>
    <name>B8DW53_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diacylglycerol kinase, catalytic region-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268646.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0402"/>
    <dbReference type="EnsemblBacteria" id="ACL28704">
        <property type="protein sequence ID" value="ACL28704"/>
        <property type="gene ID" value="BLA_0402"/>
    </dbReference>
    <dbReference type="GeneID" id="66532786"/>
    <dbReference type="KEGG" id="bla:BLA_0402"/>
    <dbReference type="HOGENOM" id="CLU_045532_2_2_11"/>
    <dbReference type="OMA" id="WLETTVE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="45"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="385" mass="41809" checksum="FFC7673A666931FB" modified="2009-03-03" version="1">MGDNQWVLILVCMIAAIIVIVGAVVGIRIALHIRRVETIKNERRRDAVHYAFVINPSKPTAGETRAFIERFCTNRGIADIMFIETQLDKDGRACALEALEQGADVVIAVGGDGTVRTVASAMGGTNHAMGIIPIGTGNLFARNMNIPVGDLEAAMLIAISHGSYKVDIGRLQLLDHPEEDHAHAFLIIAGIGFDAVMIDDTDPKLKKNISWLAYFVAGAKHLFAPKYHASVVLTGANGDQHVREDVEFRTFMSGNCGEIPVFSLMPDASFNDGLLDFEVIDTNGGIIGWMNLFGDVVHQTITRKAQQSPLSVHSTIDQVQGVSAELQLEKPVPAQVDGDMLKPTRHIRFSVDHNALIVRAPGQDAEMTGNLQPVRVDASGKPRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW73</accession>
    <name>B8DW73_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1,4-dihydroxy-2-naphthoate octaprenyltransferase</fullName>
            <shortName evidence="5">DHNA-octaprenyltransferase</shortName>
            <ecNumber evidence="5">2.5.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">menA</name>
        <name evidence="6" type="ordered locus">BLA_0422</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+) = a 2-demethylmenaquinol + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:26478"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:11173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="EC" id="2.5.1.74"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MenA family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.74" evidence="5"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619717.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0422"/>
    <dbReference type="EnsemblBacteria" id="ACL28724">
        <property type="protein sequence ID" value="ACL28724"/>
        <property type="gene ID" value="BLA_0422"/>
    </dbReference>
    <dbReference type="GeneID" id="66532806"/>
    <dbReference type="KEGG" id="bla:BLA_0422"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.450"/>
    <dbReference type="HOGENOM" id="CLU_043611_1_0_11"/>
    <dbReference type="OMA" id="YWWFILV"/>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046428">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoate octaprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01937">
        <property type="entry name" value="MenA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004657">
        <property type="entry name" value="MenA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="PTHR13929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005355">
        <property type="entry name" value="UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL28724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="356" mass="37641" checksum="27CD27FA545C7BCE" modified="2009-03-03" version="1">MQFHDYVSGMRIPTLMLGIAPVLIGVSAACRVIGMRGADGLPACGILTASSACDAGTGRIITLGLLCLLVALFLQIAVNFANDYSDGVRGTDAHRTAAVRQYTVESDFQFLENGATAEEERQARELNGPTRLVAGGVTPRAVLMAAIVNAVLACVCGLAVIVITGYWWLVFVGALCVTAAWFYVGGSHPYGYFGFGELAAFVFFGPVAALGTQFVLCGQVNGNGVYGAVVIGAVSAAVMAVNNLRDVNTDRESGKRTLAVRIGARAFTVCLCVLIALVMLAMVIPWSVMWIHMDSDLPNLSVLGGYCAVLGEIALILLTVVVEFNVAKREYRSAMRNLSWIALAVALVFVGLTMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW81</accession>
    <name>B8DW81_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NLP/P60 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_0431</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0431"/>
    <dbReference type="EnsemblBacteria" id="ACL28732">
        <property type="protein sequence ID" value="ACL28732"/>
        <property type="gene ID" value="BLA_0431"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0431"/>
    <dbReference type="HOGENOM" id="CLU_016043_1_7_11"/>
    <dbReference type="OMA" id="ILYWGSA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867659" evidence="3">
        <location>
            <begin position="28"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="157"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="272" mass="27666" checksum="9FC6AE6AC1FDF83C" modified="2009-03-03" version="1">MNTMKRSISIATAVVAASLAFTSIAPAATAADSQSGSNYVVSTRSFPKVNVAKANFFAEATSTEVDKDSNWGGLGSMDVPQTKSTAEKEAEARAQAEKEGAEQRAQEEAAAKAAREQAAAASRGQARESLTDTNANTAQQEAAPAAQPAAAPSVPTSKNGAAIAAYAQKFIGAPYVSGGTTPSGWDCSGFVMYVFSRFGINLPRTSGAQAGVGTAVPSLAEAQPGDIIANANHAAIYIGNGMIVNALNPAQGTQVTNLSAFGGAAYSIRRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWA0</accession>
    <name>B8DWA0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619726.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28751">
        <property type="protein sequence ID" value="ACL28751"/>
        <property type="gene ID" value="BLA_0450"/>
    </dbReference>
    <dbReference type="GeneID" id="66533968"/>
    <dbReference type="KEGG" id="bla:BLA_0450"/>
    <dbReference type="HOGENOM" id="CLU_2166033_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="125" mass="13295" checksum="567DD7BAE614A9C1" modified="2009-03-03" version="1">MTEHTDANRGTSRLLMTIGWIILGIGMLIAIVLRCTDQYGFITGFMLMFVFPVLALAATATATAGSVHGYWLGLAAAAVEIAILASATRGIDVFALYGGITLVCAAIGYGIGRLLHRHFHRSGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWA2</accession>
    <name>B8DWA2_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Beta-galactosidase</fullName>
            <ecNumber evidence="3 7">3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Lactase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">lacZ</name>
        <name evidence="10" type="ordered locus">BLA_0454</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 7"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268767.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="SMR" id="B8DWA2"/>
    <dbReference type="STRING" id="442563.BLA_0454"/>
    <dbReference type="CAZy" id="GH2">
        <property type="family name" value="Glycoside Hydrolase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28753">
        <property type="protein sequence ID" value="ACL28753"/>
        <property type="gene ID" value="BLA_0454"/>
    </dbReference>
    <dbReference type="GeneID" id="66532837"/>
    <dbReference type="KEGG" id="bla:BLA_0454"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.483"/>
    <dbReference type="HOGENOM" id="CLU_002346_0_2_11"/>
    <dbReference type="OMA" id="WCDHGIL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="DUF4981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bgal_small_N" evidence="9">
        <location>
            <begin position="792"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL28753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="1067" mass="119978" checksum="C56855641E3656BB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWE2</accession>
    <name>B8DWE2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage shock protein A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pspA</name>
        <name evidence="3" type="ordered locus">BLA_0494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PspA/IM30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0494"/>
    <dbReference type="EnsemblBacteria" id="ACL28793">
        <property type="protein sequence ID" value="ACL28793"/>
        <property type="gene ID" value="BLA_0494"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0494"/>
    <dbReference type="HOGENOM" id="CLU_056466_4_1_11"/>
    <dbReference type="OMA" id="KDMYIAR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007157">
        <property type="entry name" value="PspA_IM30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31088">
        <property type="entry name" value="PTHR31088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04012">
        <property type="entry name" value="PspA_IM30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="54"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="212" mass="22904" checksum="44A7F5ACEC7A7109" modified="2009-03-03" version="1">MAILKRFGDIMRANINALLDKAEDPAKMVDQMLLDLNEDLASVKKETASVMAAATNARQQVNDCKADIAKYEAAAKAAVKAGNDDDARKLLATKQQYESTLTSLETAATVAEDNAAKMRQMHDKLVNDINSLQARRAAVHAKVSVANAQQHVNEATEKTAKASRGTAAFERMEEKADRMLNEANATAELNTQASNEDIANKYLAGGLRIGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWF1</accession>
    <name>B8DWF1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-binding protein of ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BLA_0503</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218201.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0503"/>
    <dbReference type="EnsemblBacteria" id="ACL28802">
        <property type="protein sequence ID" value="ACL28802"/>
        <property type="gene ID" value="BLA_0503"/>
    </dbReference>
    <dbReference type="GeneID" id="66533634"/>
    <dbReference type="KEGG" id="bla:BLA_0503"/>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_11"/>
    <dbReference type="OMA" id="CDEYRSI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="32"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="353"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="587"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="598"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="625"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL28802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="657" mass="72985" checksum="242CC0CEE00C0402" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWF8</accession>
    <name>B8DWF8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619748.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28809">
        <property type="protein sequence ID" value="ACL28809"/>
        <property type="gene ID" value="BLA_0510"/>
    </dbReference>
    <dbReference type="GeneID" id="66533962"/>
    <dbReference type="KEGG" id="bla:BLA_0510"/>
    <dbReference type="HOGENOM" id="CLU_177542_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="102" mass="11389" checksum="544C189383612903" modified="2009-03-03" version="1">MHTTLDLSQYNDVTAYADAVHRPVVHVDYLPTPQAVARRVREAVDDRHLSMEQLAKDAHVSIQAAYSLRDSGLASLSEARRVFAVLDIHVHAYPVEMVPLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWH1</accession>
    <name>B8DWH1_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exodeoxyribonuclease 7 small subunit</fullName>
            <ecNumber evidence="3">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Exodeoxyribonuclease VII small subunit</fullName>
            <shortName evidence="3">Exonuclease VII small subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">xseB</name>
        <name evidence="5" type="ordered locus">BLA_0523</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the XseB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218233.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0523"/>
    <dbReference type="EnsemblBacteria" id="ACL28822">
        <property type="protein sequence ID" value="ACL28822"/>
        <property type="gene ID" value="BLA_0523"/>
    </dbReference>
    <dbReference type="GeneID" id="66533652"/>
    <dbReference type="KEGG" id="bla:BLA_0523"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.551"/>
    <dbReference type="HOGENOM" id="CLU_145918_0_2_11"/>
    <dbReference type="OMA" id="AKVCQRW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00337">
        <property type="entry name" value="Exonuc_7_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003761">
        <property type="entry name" value="Exonuc_VII_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037004">
        <property type="entry name" value="Exonuc_VII_ssu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34137">
        <property type="entry name" value="PTHR34137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02609">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116842">
        <property type="entry name" value="SSF116842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01280">
        <property type="entry name" value="xseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="105" mass="11507" checksum="428736A4D88F7A97" modified="2009-03-03" version="1">MAEDMEITEVSETEPQTASSLSQEERERIAQLPYEQARDELIQAVRALENGGLSLEDSMKQWELGEALAQRAQSLLSTIRAKLDAAQQAQAQTANTAGTQSNLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWH7</accession>
    <name>B8DWH7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218242.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0529"/>
    <dbReference type="EnsemblBacteria" id="ACL28828">
        <property type="protein sequence ID" value="ACL28828"/>
        <property type="gene ID" value="BLA_0529"/>
    </dbReference>
    <dbReference type="GeneID" id="66533659"/>
    <dbReference type="KEGG" id="bla:BLA_0529"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.557"/>
    <dbReference type="HOGENOM" id="CLU_562210_0_0_11"/>
    <dbReference type="OMA" id="IMLVAMK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="461" mass="51957" checksum="B92274F37909DFEC" modified="2009-03-03" version="1">MTYEQNTQWLEASKHDVTQWAAVMERDADERIIDWDWVCSLDFVAGVGAGARLDLVHDEYDAHALLMQDYAIRERLEAILENVTSVFMGDFDRNLDSFRLARALAYANRRLNDEITLIMEQGKVRRLWNVERRFERGTAFVVLHGNEDAHANEIVDRSAQLAQERAQRRNHAMNQRKAGSQMMQQASLSSFTDDKVLSEESGQTSRPAAPRRSDSQYDWRMAYLPGRDVDAVLGIDIETTGTSAWRDYIIDVGFERMNLQTPAPEGAKARDVYSETDYAADGAYDQSRLSFGVPLRCAEVANPFIAQLTGIDVTKIAGEPIFDEWPRMQQALLERLMQQPYVAHNATFEHRFFMANVEGYAEAYRNGEITILDTMPMSRHWDAGSVPSPGHPHGDNTLEAYAKRQGALDGNSHERHLGLEDAHIMLVAMRHHLGTLKVAGEGPWGPAGRGGVGGKHTGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWI5</accession>
    <name>B8DWI5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218252.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0537"/>
    <dbReference type="EnsemblBacteria" id="ACL28836">
        <property type="protein sequence ID" value="ACL28836"/>
        <property type="gene ID" value="BLA_0537"/>
    </dbReference>
    <dbReference type="GeneID" id="66533667"/>
    <dbReference type="KEGG" id="bla:BLA_0537"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.566"/>
    <dbReference type="HOGENOM" id="CLU_078717_0_0_11"/>
    <dbReference type="OMA" id="HYLEPST"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="236" mass="26034" checksum="FEE9EE245C63DD78" modified="2009-03-03" version="1">MSDTNNRHDNVASASSTANRDLTLRAMTLGDLQDVARVFDEVWPQAAPLTGTPMAYELARYFVLEYMRSATASCVAVTADGEFAGVTLARIDGQPLAFPQTEGMLGDLRQIIDENPIAKMMRSGFDHFRATDHQLELRSGVGQSTQAELLLFMVNPAVKGHGVGGALWNALLQGFRANGVHAFYLHTDTSCDYTYYEHHGLQRVAERLRADHPEDNGRADGIRDDMFVYRGEVPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWI6</accession>
    <name>B8DWI6_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BLA_0538</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218254.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0538"/>
    <dbReference type="EnsemblBacteria" id="ACL28837">
        <property type="protein sequence ID" value="ACL28837"/>
        <property type="gene ID" value="BLA_0538"/>
    </dbReference>
    <dbReference type="GeneID" id="66533668"/>
    <dbReference type="KEGG" id="bla:BLA_0538"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.567"/>
    <dbReference type="HOGENOM" id="CLU_003630_0_0_11"/>
    <dbReference type="OMA" id="TAVGDPC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="8"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="7">
        <location>
            <begin position="411"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="29"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="1378" mass="151022" checksum="46411B4FDB08C8C8" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWM8</accession>
    <name>B8DWM8_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dTDP-4-dehydrorhamnose reductase</fullName>
            <ecNumber evidence="6">1.1.1.133</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BLA_0582</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21796"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57510"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="1.1.1.133"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the dTDP-4-dehydrorhamnose reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.133" evidence="6"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218314.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0582"/>
    <dbReference type="EnsemblBacteria" id="ACL28879">
        <property type="protein sequence ID" value="ACL28879"/>
        <property type="gene ID" value="BLA_0582"/>
    </dbReference>
    <dbReference type="GeneID" id="66533710"/>
    <dbReference type="KEGG" id="bla:BLA_0582"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.613"/>
    <dbReference type="HOGENOM" id="CLU_045518_6_2_11"/>
    <dbReference type="OMA" id="IGEGRNF"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008830">
        <property type="term" value="F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008831">
        <property type="term" value="F:dTDP-4-dehydrorhamnose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000888">
        <property type="entry name" value="dTDP_sugar_isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="PTHR10491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00908">
        <property type="entry name" value="dTDP_sugar_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="7">
        <location>
            <begin position="190"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="site" description="Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose" evidence="5">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="483" mass="53590" checksum="C8C761AB4C79A2FA" modified="2009-03-03" version="1">MEFEKELKVTETNIPGLLVFDLPVHGDNRGWFKENWQKAKMTALGLPKDFQPVQNNVSFNAKRGVTRGIHAEPWDKFISLATGEIFGAWVDLRPGDTFGQVYTTRLDPSKAIYVPRGVGNSFQALEDGTAYTYLVNAHWSLEQKKTYTFVNLADPELNIQWPIPLEQAELSEADLHHPMLKDAKPMDPKRTLVTGANGQLGQSIRKYVEEHDLKGFEFTDIDEFDFSDPAAYEGYDWSLYGTIINAGAFTAVDKAETPEGRVTAWKANALGPALLAKVATEHNLTLVHVSSDYVFDGTAKVHDEDEAFSPLGVYGQTKAAGDIAVANAPKHYIVRSSWVIGNGHNFVKTMMMLSNKVSDPNDALNEVTVVDDQYGRLTFTDDMAAAIFHLLDDEDPYGTYDLTGSGDVVSWAQIAAEVFAMTNGNGDKVRPISTEQYFESAKAPVSPRPTNSTLDLAKIEETGYETTDWHDSLKAYVEVELKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWN1</accession>
    <name>B8DWN1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flippase Wzx</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">wzx</name>
        <name evidence="8" type="ordered locus">BLA_0585</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0585"/>
    <dbReference type="EnsemblBacteria" id="ACL28882">
        <property type="protein sequence ID" value="ACL28882"/>
        <property type="gene ID" value="BLA_0585"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0585"/>
    <dbReference type="HOGENOM" id="CLU_022017_0_0_11"/>
    <dbReference type="OMA" id="IYYRTDM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="330"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="479" mass="53646" checksum="401A1D44F4178510" modified="2009-03-03" version="1">MKQPKIRSVKFNVVMNTILTTSTFLFPLITVPYVSRVLGPDNNGIVSWAFTFVGYFSLVALLGFNMYGTRECAKLRDDREKLSVVVQELLVILICSTTVVYVAFVVLVFLLPRTHDELPLMFIVGTSIWLSACGAEWFYRSIEQYEYITVRNILFKIASIVLLFVFVRQTNDYLAYAAVTVLGTTGSNVLNILRLRSFVTFSRKYEMNIRRHFKPMFAFSISSITSGMYGQIDMLLLGFFSSNYALGLYQLVFKIRNMCTGVGGSVTGVMLPRLSYYEAQEGHDQTTKLMAKNFNFLLMLGLAIISALVICADPLIMILGGNDYLPGNAALKIGAPLVLLGSIGSMQSQYMVASDQEKVYTYTNVAGLVIAIVLECIFIPLWGINGAALGLVLTELSVYCIRTYILRDFMRKVRKYTDYWKIAFAWAVASIVTAGICYAMRGWNPFVQIIIAALVFCVADGGLLVLVKESFIMSMVRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWP3</accession>
    <name>B8DWP3_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BLA_0597</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218332.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0597"/>
    <dbReference type="EnsemblBacteria" id="ACL28894">
        <property type="protein sequence ID" value="ACL28894"/>
        <property type="gene ID" value="BLA_0597"/>
    </dbReference>
    <dbReference type="GeneID" id="66533727"/>
    <dbReference type="KEGG" id="bla:BLA_0597"/>
    <dbReference type="HOGENOM" id="CLU_000960_28_0_11"/>
    <dbReference type="OMA" id="LDLINMF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="69"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="574" mass="61731" checksum="A9C9D911226601D1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWR3</accession>
    <name>B8DWR3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28914">
        <property type="protein sequence ID" value="ACL28914"/>
        <property type="gene ID" value="BLA_0621"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0621"/>
    <dbReference type="HOGENOM" id="CLU_3402292_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="30" mass="3581" checksum="C95484D50AA0CE30" modified="2009-03-03" version="1">MSLYLGLFHIRNPQNIEDAWFPNLSRETFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWR5</accession>
    <name>B8DWR5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cellobiose-phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0623"/>
    <dbReference type="CAZy" id="GH94">
        <property type="family name" value="Glycoside Hydrolase Family 94"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28916">
        <property type="protein sequence ID" value="ACL28916"/>
        <property type="gene ID" value="BLA_0623"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0623"/>
    <dbReference type="HOGENOM" id="CLU_999886_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033432">
        <property type="entry name" value="GH36_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17167">
        <property type="entry name" value="Glyco_hydro_36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_hydro_36" evidence="2">
        <location>
            <begin position="39"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="334" mass="36478" checksum="736B5DDACC409F65" modified="2009-03-03" version="1">MVATRKVPPSASQNFMAPKARAMFLNKPVPGIIAGMFVLYGEQYAQILEQFGEACGMGADEVANETAEVRKTIAEVREATLTAGWDGAWFRRAYDANGNPVGTNEDSEGKIYIEPQGMCVMAGIGVDDGKAAKALESTKELLTCRWGTAILAPAYSTYRIELGEISSYPRGYKENGGIFCHNNPWISIANAKINNNDEAFNVYKRTCPAYTEEYSEIHRTEPYVYCQMVAGPEAPTPGEGKNSWLTGTAAWTFVDVSQHLLGVQPTFDGLKIEPHLPPNFGELHIERTWRGTRYIIDVTRTGEQSLTVDGQPVSGTVVPTAATGTEEVHVALTI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWS3</accession>
    <name>ATPG_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F1 sector gamma subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpG</name>
        <name type="ordered locus">BLA_0631</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219178.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DWS3"/>
    <dbReference type="SMR" id="B8DWS3"/>
    <dbReference type="STRING" id="442563.BLA_0631"/>
    <dbReference type="EnsemblBacteria" id="ACL28924">
        <property type="protein sequence ID" value="ACL28924"/>
        <property type="gene ID" value="BLA_0631"/>
    </dbReference>
    <dbReference type="GeneID" id="66533762"/>
    <dbReference type="KEGG" id="bla:BLA_0631"/>
    <dbReference type="HOGENOM" id="CLU_050669_0_0_11"/>
    <dbReference type="OMA" id="MQITSAM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0139">CF(1)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000148601" description="ATP synthase gamma chain">
        <location>
            <begin position="1"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00815"/>
        </source>
    </evidence>
    <sequence length="306" mass="34023" checksum="767EB3194D4BD6E4" modified="2009-03-03" version="1">MASQLALKSRIASTGSLEKIFNAQEMIAASHIAQARQLALDSKPYTDAIFDAVQTLVSHTHISHPIVKKDEGNPRVAVLALTADRGMAGAYTSSIIRETEDLLARLEGEGKQPQLYVYGRRGVSYYHYRNRPLAQSWEGDTEKPGVEVANAISRALLKAYMEPVDEGGVAELYIVYTEFINMVVQKVRVLRMLPVEVVKEDKSHLNVPDTTTAPQVRPLYSFEPSLDEVLDTVLPRYVRSRIHECLFEAAASEVACRQNAMHTATENARDLINDLTRKLNASRQASITQELTEIIGSADALNKKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWT1</accession>
    <name>B8DWT1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inosine-uridine nucleoside N-ribohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">iunH</name>
        <name evidence="4" type="ordered locus">BLA_0639</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219165.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0639"/>
    <dbReference type="EnsemblBacteria" id="ACL28932">
        <property type="protein sequence ID" value="ACL28932"/>
        <property type="gene ID" value="BLA_0639"/>
    </dbReference>
    <dbReference type="GeneID" id="66533770"/>
    <dbReference type="KEGG" id="bla:BLA_0639"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.670"/>
    <dbReference type="HOGENOM" id="CLU_036838_2_0_11"/>
    <dbReference type="OMA" id="HAPDIHG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045437">
        <property type="term" value="F:uridine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015910">
        <property type="entry name" value="I/U_nuclsd_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="PTHR12304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="SSF53590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01247">
        <property type="entry name" value="IUNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IU_nuc_hydro" evidence="3">
        <location>
            <begin position="5"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="313" mass="33996" checksum="C467489097A2BF2B" modified="2009-03-03" version="1">MVKKIILDCDPGHDDAVAILLAIGNPNIELLGVTTVGGNQSLEKVTYNARAVLEKAHAPNIPVHAGCARPIIRDPQVAATIHGETGLDGVELPEPTRPLDPGHAVNWIIDTIMSNEPGTITLVPTGPLTNIALAARLEPRIVERVKEVVLMGGGVHVGNWSAVAEFNIKVDPDAAHIVFNEKWPVTMIGLDLTHQALCKPEKQRMIEGIGTPLASFVSGLMDFFRKSYAENQDFVDPPVHDPCTVAYLIDPTVITTRRCPVDVELRGELTLGMTVADLRGPEPSAEECHTQVAMKLDFDKFWNLVTDAIRRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWT7</accession>
    <name>B8DWT7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Modification methylase EcoRI</fullName>
            <ecNumber evidence="1">2.1.1.72</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mte</name>
        <name evidence="1" type="ordered locus">BLA_0645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.72" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219155.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0645"/>
    <dbReference type="REBASE" id="19803">
        <property type="entry name" value="M.BanADORF645P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28938">
        <property type="protein sequence ID" value="ACL28938"/>
        <property type="gene ID" value="BLA_0645"/>
    </dbReference>
    <dbReference type="GeneID" id="66533778"/>
    <dbReference type="KEGG" id="bla:BLA_0645"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.673"/>
    <dbReference type="HOGENOM" id="CLU_057063_0_0_11"/>
    <dbReference type="OMA" id="PRHYELY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025247">
        <property type="entry name" value="EcoRI-like_methylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13651">
        <property type="entry name" value="EcoRI_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="363" mass="41678" checksum="2A748854FEDC0C12" modified="2009-03-03" version="1">MATPLNRANQAKEDEFYTQLSDIESELKHYRKHFAGKTVLCNCDDPFESNFFKYFCLNFNRLKLKKLIATCYSGSPITGNELTLFGDDTEEERRTPYKAVVTSVRDANGDGATSMVDVAELFKQGENLCERLEGNGDFRSEECLRLLDEADIVVTNPPFSKFREFVSTLVEHDKKFIIIGNQNAITYKEFFPLLRDNKVWLGYGCGDMAFKVPDDYEPRKTRYWQDESGQKWRSMGNACWYTNLDIKKRHEDLVLVKRYNRDDYPKYDNYEAINVGKVIDIPCDYEGIMGVPVTFMDKFNPDQFEIIGLLAGNIRGLAGIPSSTGKDGPYINGKLKFGRILVRNLHPEPRPYETVTLEEAQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWT8</accession>
    <name>B8DWT8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phage integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0646</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219153.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0646"/>
    <dbReference type="EnsemblBacteria" id="ACL28939">
        <property type="protein sequence ID" value="ACL28939"/>
        <property type="gene ID" value="BLA_0646"/>
    </dbReference>
    <dbReference type="GeneID" id="66533779"/>
    <dbReference type="KEGG" id="bla:BLA_0646"/>
    <dbReference type="HOGENOM" id="CLU_027562_17_1_11"/>
    <dbReference type="OMA" id="NGWEYRI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="179"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="406" mass="46446" checksum="EB8AD7DE3C0F025D" modified="2009-03-03" version="1">MAKRETSGEIKELERGRRYSIRVRLAPDDTHQSWHWSKSRKVQGNKAEATAALVAYRQELEDARSGKSVTVGEYATDFQAKRRALGKVSSLTIERDQHEIDRIVKFLGDVRVVDLDAQRIEKAYLHMAEQDNASPDAIHKVHMKLAQIMRKAYLEELIERNPCDAVEDIKRPKVSPQKRKETRITKEQALEFVHKLKNEPQDGRIVAVWLGLATGLRRGEALALVWEDVDLENARLRIRKQYGKEKVLKDPKTAKSRRTISIDNQTVEFLTKWKTKQAGLFAEVGLTLQESSPVCSNDLCVFLDPDNFSRWRRKFYVEEGLAHYAHESTYIDRRGIERVKRSGYIGPNFQALRRAQATLLVAGGVDPKTVQARLGHESLNTTLNIYAEEVGENDRKAADFMGKLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWV2</accession>
    <name>B8DWV2_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Valine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Valyl-tRNA synthetase</fullName>
            <shortName evidence="7">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 12" type="primary">valS</name>
        <name evidence="12" type="ordered locus">BLA_0660</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="7"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219130.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0660"/>
    <dbReference type="EnsemblBacteria" id="ACL28953">
        <property type="protein sequence ID" value="ACL28953"/>
        <property type="gene ID" value="BLA_0660"/>
    </dbReference>
    <dbReference type="GeneID" id="66533793"/>
    <dbReference type="KEGG" id="bla:BLA_0660"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.688"/>
    <dbReference type="HOGENOM" id="CLU_001493_0_2_11"/>
    <dbReference type="OMA" id="RQWYIRN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02005">
        <property type="entry name" value="Val_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022874">
        <property type="entry name" value="Valine-tRNA_ligase_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="10">
        <location>
            <begin position="29"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1" evidence="10">
        <location>
            <begin position="138"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="11">
        <location>
            <begin position="691"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="889"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="601"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="604"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACL28953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="930" mass="104812" checksum="460D56B35490B424" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWV3</accession>
    <name>B8DWV3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_0661</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219128.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0661"/>
    <dbReference type="EnsemblBacteria" id="ACL28954">
        <property type="protein sequence ID" value="ACL28954"/>
        <property type="gene ID" value="BLA_0661"/>
    </dbReference>
    <dbReference type="GeneID" id="66533794"/>
    <dbReference type="KEGG" id="bla:BLA_0661"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.689"/>
    <dbReference type="HOGENOM" id="CLU_091233_5_0_11"/>
    <dbReference type="OMA" id="AGDENYI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="159" mass="17683" checksum="3A70CDDBB2402626" modified="2009-03-03" version="1">MTSTHTTTERRYVDGRTLDEKDNIILDILEHNGRATLAQLAEAASLSISATQSRVQKLEKNGVIVGYRAIIHYPEQTTGTIHAFVSVTPLEYDENANIPEKLEHISGIDSCDAVSGSQVYVLTVTVPTVPQLEDLVTKIHRIVPSNVETTMVLHRYFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWV8</accession>
    <name>B8DWV8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219123.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0666"/>
    <dbReference type="EnsemblBacteria" id="ACL28959">
        <property type="protein sequence ID" value="ACL28959"/>
        <property type="gene ID" value="BLA_0666"/>
    </dbReference>
    <dbReference type="GeneID" id="66533799"/>
    <dbReference type="KEGG" id="bla:BLA_0666"/>
    <dbReference type="HOGENOM" id="CLU_148679_0_0_11"/>
    <dbReference type="OMA" id="YETDMEL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019592">
        <property type="entry name" value="DUF2469"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10611">
        <property type="entry name" value="DUF2469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="104" mass="12477" checksum="AA2997D709F95E0D" modified="2009-03-03" version="1">MSAEDLDNYETDAELALYREYRDVIKLFKYVVETERRFYLANKVDFNVRSAGQDVYFDVQLSDAWVWDVYRSSRFVKNVRIVTFKDVNVEEVQQTDIDIPEDMQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSI4</accession>
    <name>GATC_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C</fullName>
            <shortName evidence="1">Asp/Glu-ADT subunit C</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatC</name>
        <name type="ordered locus">BLA_0670</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatC family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269234.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DSI4"/>
    <dbReference type="SMR" id="B8DSI4"/>
    <dbReference type="STRING" id="442563.BLA_0670"/>
    <dbReference type="EnsemblBacteria" id="ACL28963">
        <property type="protein sequence ID" value="ACL28963"/>
        <property type="gene ID" value="BLA_0670"/>
    </dbReference>
    <dbReference type="GeneID" id="66533803"/>
    <dbReference type="KEGG" id="bla:BLA_0670"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.698"/>
    <dbReference type="HOGENOM" id="CLU_105899_1_0_11"/>
    <dbReference type="OMA" id="VTPMAMK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00122">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="Asp/Glu-ADT_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="Glu-tRNAGln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="SSF141000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00135">
        <property type="entry name" value="gatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000122555" description="Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00122"/>
        </source>
    </evidence>
    <sequence length="98" mass="10512" checksum="7E05C6F8BF386289" modified="2009-03-03" version="1">MPTFTREEIVHLGDLARIALTDEEITRMQSELNVIADAIDSVQEVATADVEPTANPVPLEAYLRPDVPATPLTQAEALSGAPVAEDGMFVAPRILGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSL3</accession>
    <name>B8DSL3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD+ synthetase</fullName>
            <ecNumber evidence="2">6.3.5.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.5.1" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0699"/>
    <dbReference type="EnsemblBacteria" id="ACL28992">
        <property type="protein sequence ID" value="ACL28992"/>
        <property type="gene ID" value="BLA_0699"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0699"/>
    <dbReference type="HOGENOM" id="CLU_616314_0_0_11"/>
    <dbReference type="OMA" id="RRIDTTY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041856">
        <property type="entry name" value="NAD+_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="465" mass="50409" checksum="FBDDE71868AFD341" modified="2009-03-03" version="1">MRFARTSGPDPPSIHLALAGAMIICNGPASNASLEKDLYRRSLISGQSARLLCCYAYCSSGQGDSTGDVTVGGQEIIAENGSILAQSEPFGDGFAVADVDVESLWGARRGMSSFHVEPTPQYADYHETMFDMTIPDHPLMRPVSKQPFIPADEKMRADCCSLAVTMQAHGLAARVGAQNADHLVIDTTNSSVTNTALAVLAVARFYDLERPAVPDMYVAISQDAQNGQSANVKLIEQLADALGLPLATLASARAEQQNAAQSSPEHPVLDIQELIGDTSWLIVNPSDMTQLALGLTQFPFDLGRQYGINSQIAHTFVPVIPRQYAQECADGNLQTLLGAICDPDNELHIPEHDTVSMSESAELGPAVVEDFYLDGFLRAQYRPAKTFALARQAFAGEYGEHELPGWMKAFYERFFGSQFLRHSLPDGPRIGSAGLDLRDGFMMPTYAQSTLWMNEVDALLNAATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSM3</accession>
    <name>B8DSM3_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF262 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269166.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0709"/>
    <dbReference type="EnsemblBacteria" id="ACL29002">
        <property type="protein sequence ID" value="ACL29002"/>
        <property type="gene ID" value="BLA_0709"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0709"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.740"/>
    <dbReference type="HOGENOM" id="CLU_626527_0_0_11"/>
    <dbReference type="OMA" id="IGVCRKG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="DUF262"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="DUF262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF262" evidence="1">
        <location>
            <begin position="11"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="437" mass="49859" checksum="634B5D451D1E2A43" modified="2009-03-03" version="1">MSISASEKPLSKVFTSDYRFTIPSFQRSYSWHDAQMRQLVNDVMDACALHDGPYFLGSLILVHDERGMHQVIDGQQRLVSLSILFSILLALEEDPQLTSSLEGLLMEAGDKLRGINAEPRLTLREQDEGFFREYVQQGDLEALFDLRETDIHTQAQRNIQGNTRCAYDILARMQDDERRQFAQYLVNDVMFVIVTTDDISGAYRIFDVMNMRGMPLTPSDVFKAKVVSSISPAARDAYARYWDEIMEPMGDDTERIERFFKDLDLIATKTPLCESLIADFMDHVLERYMRKGEGIEYIDEVLRPYAIANEIIHRPGESLLPDDVVDLLIGLNDYPSKDWHPVAMWVLVHSLKGLDDPDTVVFERQTADHGREHQVKVHDAQRLRDVLASLDRVTGTDCLNGKSELERRTRASTIVRDLNKGALLKLVCKGRASSLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSQ3</accession>
    <name>B8DSQ3_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiamine diphosphokinase</fullName>
            <ecNumber evidence="1">2.7.6.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BLA_0739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.6.2" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218696.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0739"/>
    <dbReference type="EnsemblBacteria" id="ACL29032">
        <property type="protein sequence ID" value="ACL29032"/>
        <property type="gene ID" value="BLA_0739"/>
    </dbReference>
    <dbReference type="GeneID" id="66533500"/>
    <dbReference type="KEGG" id="bla:BLA_0739"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.770"/>
    <dbReference type="HOGENOM" id="CLU_044237_1_2_11"/>
    <dbReference type="OMA" id="AREFHIY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="SSF63862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="SSF63999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPK_B1_binding" evidence="7">
        <location>
            <begin position="171"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="268" mass="28337" checksum="61110821AC2C1F84" modified="2009-03-03" version="1">MGAGIICVARQRKSPASQAEGVTTNTASRICVVFGAGEYYTRPYSLPEHAFVVAADGGYAHARELGVHVDVVVGDFDSTEDLATESTSDPGMRTLRLPPEKDDPDMLSALKVGWRHGSREFHIYGGLGGRVDHTISDIQQTAIVASHGGIAYLHGDGRIVTAISDAALHFAAHEVADTQYVSVFAHSDSVRDVTERGLKYRLDHATLSNLQVNGLSNEFIDGDAAQIAVGGGIAIIVFDDRAPLPELVGATPHGTLGEPSTHVTDALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSU8</accession>
    <name>B8DSU8_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 7">Transcriptional regulator MraZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">mraZ</name>
        <name evidence="10" type="ordered locus">BLA_0785</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Forms oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MraZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218636.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0785"/>
    <dbReference type="EnsemblBacteria" id="ACL29077">
        <property type="protein sequence ID" value="ACL29077"/>
        <property type="gene ID" value="BLA_0785"/>
    </dbReference>
    <dbReference type="GeneID" id="66533547"/>
    <dbReference type="KEGG" id="bla:BLA_0785"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.818"/>
    <dbReference type="HOGENOM" id="CLU_107907_0_0_11"/>
    <dbReference type="OMA" id="RGQERCL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16321">
        <property type="entry name" value="MraZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16320">
        <property type="entry name" value="MraZ_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01008">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003444">
        <property type="entry name" value="MraZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035644">
        <property type="entry name" value="MraZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020603">
        <property type="entry name" value="MraZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035642">
        <property type="entry name" value="MraZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038619">
        <property type="entry name" value="MraZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34701">
        <property type="entry name" value="PTHR34701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02381">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00242">
        <property type="entry name" value="TIGR00242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="9">
        <location>
            <begin position="22"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB" evidence="9">
        <location>
            <begin position="93"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL29077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="161" mass="18009" checksum="52BA535D34BFA96B" modified="2009-03-03" version="1">MTDEPVEPDSSAPVVPPLLLGTYNPKIDAKGRMAIPAKMRAQLGEGMVMARGQERCVYLLPQSEFRRIAAQIQRVSVGNKAARQYLRVFLSGAVDQDTDKQGRVVVPQMLREYADLGDDIVVIGVGTRAEIWNRKAWEQYLSDNEPEYSDIADDVLPDLEF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSW4</accession>
    <name>HIS7_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Imidazoleglycerol-phosphate dehydratase</fullName>
            <shortName evidence="1">IGPD</shortName>
            <ecNumber evidence="1">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisB</name>
        <name type="ordered locus">BLA_0801</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218611.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DSW4"/>
    <dbReference type="SMR" id="B8DSW4"/>
    <dbReference type="STRING" id="442563.BLA_0801"/>
    <dbReference type="EnsemblBacteria" id="ACL29093">
        <property type="protein sequence ID" value="ACL29093"/>
        <property type="gene ID" value="BLA_0801"/>
    </dbReference>
    <dbReference type="GeneID" id="66533563"/>
    <dbReference type="KEGG" id="bla:BLA_0801"/>
    <dbReference type="HOGENOM" id="CLU_044308_2_0_11"/>
    <dbReference type="OMA" id="ARHGLFD"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="PTHR23133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000118216" description="Imidazoleglycerol-phosphate dehydratase">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00076"/>
        </source>
    </evidence>
    <sequence length="200" mass="21718" checksum="D70EC2D70B1E4052" modified="2009-03-03" version="1">MARTAHIVRQTSESSIDLELNLDGTGKTNIETTVPFYNHMMTALGKHSLIDLNIVASGDTDIDAHHTVEDTAIVFGEALRQALGDKRGIRRFADATVPLDEALAKAVVDVSGRPYCVCSGEPEGFQYAMIGGHFTGSLVRHVMESIAFHAQICLHMHLIAGRDPHHIAEAEFKALARALRFAIEPDPRIQGLIPSTKGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSW5</accession>
    <name>B8DSW5_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidinol-phosphate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">hisC</name>
        <name evidence="5" type="ordered locus">BLA_0802</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218610.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0802"/>
    <dbReference type="EnsemblBacteria" id="ACL29094">
        <property type="protein sequence ID" value="ACL29094"/>
        <property type="gene ID" value="BLA_0802"/>
    </dbReference>
    <dbReference type="GeneID" id="66533564"/>
    <dbReference type="KEGG" id="bla:BLA_0802"/>
    <dbReference type="HOGENOM" id="CLU_017584_3_1_11"/>
    <dbReference type="OMA" id="IWLNANE"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="4">
        <location>
            <begin position="33"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="388" mass="43263" checksum="39B41332908613BA" modified="2009-03-03" version="1">MSEAMIPADLPLRNDLIGEVPYGAPQLDVPVCLNVNENPYPPDHAVVRSIVEHVKQVAPTLNRYPDREHIELREAFVRYLKEESGAQLTVEQVWGANGSNEIMLQLFQAFGGPGRAALGCDPAYSMYPEYARDTFTSWYTTHRKPDFTLDVDHTIDDIDAIQPAMVVLTSPNNPTGTELPMTDLKRILEHCQSAQVAGAHDGVHPIVVVDEAYIEFRNPGTPSATTLINDYDNLAVSRTMSKAFAFAGARVGYLAASEGIVDCLRIVRMPYHLSAVTQAVALAAFDHRKEQLSQVDHLREIREQTAAWLKEQTYKGQPLEVAPSQSNFLLFGGHFDDRGAIFDQMLQRGVLIRVVGPEGWLRVCMGTDEEMRRFREALVESMRAVENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSX5</accession>
    <name>B8DSX5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Possible NifR3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BLA_0812</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218596.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0812"/>
    <dbReference type="EnsemblBacteria" id="ACL29104">
        <property type="protein sequence ID" value="ACL29104"/>
        <property type="gene ID" value="BLA_0812"/>
    </dbReference>
    <dbReference type="GeneID" id="66533574"/>
    <dbReference type="KEGG" id="bla:BLA_0812"/>
    <dbReference type="HOGENOM" id="CLU_013299_0_0_11"/>
    <dbReference type="OMA" id="RPWLFAD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024036">
        <property type="entry name" value="tRNA-dHydroUridine_Synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004652">
        <property type="entry name" value="tRNA_dU_NifR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00737">
        <property type="entry name" value="nifR3_yhdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="7">
        <location>
            <begin position="53"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="417" mass="46198" checksum="7DB10BD793282F1E" modified="2009-03-03" version="1">MSEQETILNTSRQREASPDAKDCADAGARLEPVLAGPLAPIRLGDVMVNTPVMLSPMAGVTNWPFRVLCEEYGPDGLYVAEMVTARALVERNPKALRLCRFAPSERIRSLQLYGVNPSIMEQAARFLVDNGMMDHLDLNFGCPVPKVTRRGGGSALPWKTDLFTEIVQRVVAVCEPANIPVTAKIRVGLDHEHETFLEAGRIAQEEGCSAVTLHARTTAEYYGGHSDWCRIGELVSTLDIPVFGNGDIWGAEDAIAMVNETGCAGVAIGRGCQGRPWLFGNIGNAFAGSDVRINPTLGEVGRIIMRHAELLTEFYDGDERMAVHDLRKHVAWYLKGFPVGGSTRRAFMECESLKDVREQVDALDPNIEYPERVVDQPRGRVRFAKKVHLPYGWLDSRTTTHEERERLFGDDPMDASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSX6</accession>
    <name>B8DSX6_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glycyl-tRNA synthetase</fullName>
            <shortName evidence="7">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glyS</name>
        <name evidence="7" type="synonym">glyQS</name>
        <name evidence="9" type="ordered locus">BLA_0813</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of glycine to tRNA(Gly).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="7"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218594.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0813"/>
    <dbReference type="EnsemblBacteria" id="ACL29105">
        <property type="protein sequence ID" value="ACL29105"/>
        <property type="gene ID" value="BLA_0813"/>
    </dbReference>
    <dbReference type="GeneID" id="66533575"/>
    <dbReference type="KEGG" id="bla:BLA_0813"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.847"/>
    <dbReference type="HOGENOM" id="CLU_015515_2_1_11"/>
    <dbReference type="OMA" id="EPSYGID"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00253_B">
        <property type="entry name" value="Gly_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022961">
        <property type="entry name" value="Gly_tRNA_ligase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="7"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="210"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="322"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="195"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="205"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="282"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="326"/>
            <end position="329"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL29105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="491" mass="55844" checksum="BEE17EED3FE0E16B" modified="2009-03-03" version="1">MANSKIDEVVSLAKRRGFVFPAGEIYGGTRSAWDYGPLGVALKDNIKREWWRSMVVTRPDVVGVDTSIILPSEVWVASGHVSVFNDPLIECLTCHKRHRADKLEESYAEKHNDQLPPNGLKDIVCPDCGTRGNWTEPRDFNMMLRTHLGPVEDENSLHYLRPETAQGIFVDFKNVMTSSRSKPPFGIANTGKSFRNEITPGNFIFRTREFEQMEMEFFVEPGTDEDWHQYWINARTQWYIDLGVNPENLRHYEHPKEKLAHYSKRTVDIEYRFGFQGSDWGELEGVANRTDFDLGAHAKHSGEDLSYFNQATGEKYIPYVIEPAAGLSRSLMAFLVDAYDVDEAPNTKGGVDKRTVLRLDPRLAPVKAAVLPLSKKPELQSVAQDLAQDLRLNDWMIDYDESGAIGRRYRRQDEIGTPLCITVDFDTLDDQAVTIRERDTMQQERVALTQVADYVAKRINDKRTRVPLKPVSMGGAEWPETVHIAEAGGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSY5</accession>
    <name>B8DSY5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Possible inosine-uridine preferring nucleoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0822</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0822"/>
    <dbReference type="EnsemblBacteria" id="ACL29114">
        <property type="protein sequence ID" value="ACL29114"/>
        <property type="gene ID" value="BLA_0822"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0822"/>
    <dbReference type="HOGENOM" id="CLU_036838_3_1_11"/>
    <dbReference type="OMA" id="TPVAEWN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="PTHR12304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="SSF53590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IU_nuc_hydro" evidence="3">
        <location>
            <begin position="12"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="409" mass="42820" checksum="59558FB991C3F307" modified="2009-03-03" version="1">MTNPQTDIHHIVASMDTGIDDALALALLLAQPNVRLHGVSASYGNVLEQPAARNTRAVLSLLGRSDIPVFDGARHPSWAPYFIADAGCAQFHGSDGLGDVSTGDGDNADFTPTTPGETLASDANGLVTLTAPQIRNLTECGTAISVGGYQVGEKHADLPTMPELTIPSGSAHTPTPEKLEFPQESCSQATAGARMIVDAARAFGPDLTILVTGPLTDIDTALTLDPEAVRQARIVFMGGTLTQEGNCYDLVCETNMIQDPEAADRVLRSGADVTMVGLDVTHRCLLGSSDITPWNAAHTEASRFLTAIAEFSIRANAASEPIFAAGMPLHDPLAAAVALDATLVGTLDLPMCVETRSGDGTGVRGRTIGNPQGFIDASLCPTHVAVGVDRERFLARFTGDIANLLTSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSZ4</accession>
    <name>B8DSZ4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0831</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218571.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0831"/>
    <dbReference type="EnsemblBacteria" id="ACL29123">
        <property type="protein sequence ID" value="ACL29123"/>
        <property type="gene ID" value="BLA_0831"/>
    </dbReference>
    <dbReference type="GeneID" id="66533593"/>
    <dbReference type="KEGG" id="bla:BLA_0831"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.865"/>
    <dbReference type="HOGENOM" id="CLU_117223_1_0_11"/>
    <dbReference type="OMA" id="VGKDWSG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021412">
        <property type="entry name" value="DUF3052"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11253">
        <property type="entry name" value="DUF3052"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="138" mass="15203" checksum="1E7E66A45515727A" modified="2009-03-03" version="1">MNQTASDNAEEFGFRQGDLVQEWLWDDDVDDSIREKIEKLTNEDLVDEEYDSAVDGAIIWWRDGDDEDELSDTIVDAYAVLGDDGPLWVLTPKPGREGAPSPSTVQNAAKTAGMNAATPLTVSDDWNGILLRAFGKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSZ5</accession>
    <name>B8DSZ5_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endopeptidase La</fullName>
            <ecNumber evidence="1">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sdrC</name>
        <name evidence="3" type="ordered locus">BLA_0832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0832"/>
    <dbReference type="MEROPS" id="S16.012"/>
    <dbReference type="EnsemblBacteria" id="ACL29124">
        <property type="protein sequence ID" value="ACL29124"/>
        <property type="gene ID" value="BLA_0832"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0832"/>
    <dbReference type="HOGENOM" id="CLU_042037_0_0_11"/>
    <dbReference type="OMA" id="TDHTFPF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Lon proteolytic" evidence="2">
        <location>
            <begin position="54"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="281" mass="29919" checksum="B582035C0868CBA8" modified="2009-03-03" version="1">MFRRLRARWHNRPKRYFIGLFTFLLALCLMLAPSPYVVESPGPTENVLGKADGKEVISVSNATTYPDRGELLLTTVNASGVPGYPISNIWALIGWLDPHMNVLPSEAVFPVGQSSEEYDQEAKADMDSSMEAATAAGLAYAKRLGAKVSDADVSMHIEDIGGPSAGMMYALGLVDKLTPENETNGVTVAGTGTIDKTGKVGAIGGIDLKMIGALQDGATWFLAPEENCDEVVGHVPNGLRDVKVSTLEEAYTALVKIGKGDADSLPHCTVRRAADHNMAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT02</accession>
    <name>B8DT02_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Diaminopimelate epimerase</fullName>
            <shortName evidence="8">DAP epimerase</shortName>
            <ecNumber evidence="4 8">5.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PLP-independent amino acid racemase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">dapF</name>
        <name evidence="10" type="ordered locus">BLA_0839</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:15393"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="5.1.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.7" evidence="4 8"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619846.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0839"/>
    <dbReference type="EnsemblBacteria" id="ACL29131">
        <property type="protein sequence ID" value="ACL29131"/>
        <property type="gene ID" value="BLA_0839"/>
    </dbReference>
    <dbReference type="GeneID" id="66533601"/>
    <dbReference type="KEGG" id="bla:BLA_0839"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.873"/>
    <dbReference type="HOGENOM" id="CLU_053306_4_0_11"/>
    <dbReference type="OMA" id="HVAMRVH"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008837">
        <property type="term" value="F:diaminopimelate epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00197">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018510">
        <property type="entry name" value="DAP_epimerase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001653">
        <property type="entry name" value="DAP_epimerase_DapF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31689">
        <property type="entry name" value="PTHR31689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01678">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00652">
        <property type="entry name" value="DapF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01326">
        <property type="entry name" value="DAP_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="92"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="237"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="247"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL29131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="300" mass="32826" checksum="0356CB23942A54EE" modified="2009-03-03" version="1">MSLPEHMIKAQGTGNDFVMYADRSGEHAPQKQDIIQLCDRHFGIGADGLIRITRPGHVADLDGHDAQKMRKEGVEWFMDYRNADGTLAEMCGNGTRATAQFLVQQGMLELEEGDAFKLGTRAGVKRITRMPDNPELGRQLWRVDMGSWSMGAEDEYTVTIPGDTGSGKGTFVDMGNPHVVTVVEDAYSTLPVLGELDLTRAPQVSPELPNGQNVEFARIDNLDTERDLGDASMRVYERGCGETMACGTGLCATAIVLRAKTQIDHWRIRIPGGIVRVDVTDDSVMLTGAAALTAEFRLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT25</accession>
    <name>B8DT25_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">1,4-beta-N-acetylmuramidase</fullName>
            <ecNumber evidence="5">3.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lytC</name>
        <name evidence="5" type="ordered locus">BLA_0862</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="5"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619855.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0862"/>
    <dbReference type="CAZy" id="GH25">
        <property type="family name" value="Glycoside Hydrolase Family 25"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29154">
        <property type="protein sequence ID" value="ACL29154"/>
        <property type="gene ID" value="BLA_0862"/>
    </dbReference>
    <dbReference type="GeneID" id="66533841"/>
    <dbReference type="KEGG" id="bla:BLA_0862"/>
    <dbReference type="HOGENOM" id="CLU_577050_0_0_11"/>
    <dbReference type="OMA" id="FYKQITW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870870" evidence="3">
        <location>
            <begin position="35"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="4">
        <location>
            <begin position="345"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="4">
        <location>
            <begin position="415"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="542" mass="60422" checksum="2B32D5D35B37E47A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT38</accession>
    <name>B8DT38_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BLA_0875</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219234.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0875"/>
    <dbReference type="EnsemblBacteria" id="ACL29167">
        <property type="protein sequence ID" value="ACL29167"/>
        <property type="gene ID" value="BLA_0875"/>
    </dbReference>
    <dbReference type="GeneID" id="66533854"/>
    <dbReference type="KEGG" id="bla:BLA_0875"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.915"/>
    <dbReference type="HOGENOM" id="CLU_610685_0_0_11"/>
    <dbReference type="OMA" id="GRLGWQF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="25"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="341"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL29167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="446" mass="48293" checksum="63E5E84E7739FB37" modified="2009-03-03" version="1">MFIFGQAWKMLCRHPLRSLLIVLVSAAIAMWSTFGGAVLQENHKARTETLDKQSNTAVIRPSSQLLETRQGDDSSWTEHYLSWSDYDKLASAGQTQGMQYKYTVAESVPVRESKSVQAITTGKTSDASADKTGGNLTLQSFYTAEAAQANEYGPYEVVEGKGLDYQNSLAQNVLISEALAKKNNLKVGSTITIGNPTDAKKTYEYTVVGIYRYTGNPDNAQGDDAKFAKDNRNNVLYTTYTTFAVNGFDTTKGKGWSIPDLNVVFTFQNRSDIDKFAAALKADLPKGFTVSSPTITHYMQSIEALGTLAGTTRIIMIVLWICGALALLGLVLLAALPRSNEIGMGMLVGLSKGRLAWQFMLETFMPTLVGLAVGLVLGACTANPLAGALGAQHDVHATGGLVWQVIWIGVLCSVALAIVAGLRVTFFRTIRLFESPYISDSADSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT53</accession>
    <name>B8DT53_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="2">3.2.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">aes</name>
        <name evidence="2" type="ordered locus">BLA_0890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269246.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0890"/>
    <dbReference type="EnsemblBacteria" id="ACL29182">
        <property type="protein sequence ID" value="ACL29182"/>
        <property type="gene ID" value="BLA_0890"/>
    </dbReference>
    <dbReference type="GeneID" id="66533869"/>
    <dbReference type="KEGG" id="bla:BLA_0890"/>
    <dbReference type="HOGENOM" id="CLU_012494_5_2_11"/>
    <dbReference type="OMA" id="MYPVISM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="91"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="273" mass="29664" checksum="5613078717A5C53A" modified="2009-03-03" version="1">MQYFETTIIGIDGSGARFAGYLPENYPDIVPDRKRPTVLVLPGGGYEMTTGREGEPIALQFLAADYNAFVLHYSCKPSVYPIAVLEVAEAMRQIRAHADEWNVDTARIAVIGFSAGGHLAADFATSASDAALVAHGYDPDELRPNALMLSYPVITSGRFRHDGSFRALLGERYGEESAMNEVSIEQHIDAKTPPVFVWHTMPDDCVPVENTLQLIAACKAANVPIEAHLYPAGGHGLSLGTAQTAWGGVNSIEPAVQSWIFLAKDWLDRTFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT55</accession>
    <name>B8DT55_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GyrI-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619864.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0892"/>
    <dbReference type="EnsemblBacteria" id="ACL29184">
        <property type="protein sequence ID" value="ACL29184"/>
        <property type="gene ID" value="BLA_0892"/>
    </dbReference>
    <dbReference type="GeneID" id="66533872"/>
    <dbReference type="KEGG" id="bla:BLA_0892"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.934"/>
    <dbReference type="HOGENOM" id="CLU_083625_0_0_11"/>
    <dbReference type="OMA" id="GKHHEIY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029442">
        <property type="entry name" value="GyrI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008319">
        <property type="entry name" value="UCP031644"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06445">
        <property type="entry name" value="GyrI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031644">
        <property type="entry name" value="UCP031644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GyrI-like" evidence="1">
        <location>
            <begin position="18"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="218" mass="24788" checksum="29C55DB195144324" modified="2009-03-03" version="1">MPYDVKREQKNLYVPGKTPAIVEVPAMQFVAVRGAGDPNDPHGEYQSALQLLYGISFTIKMSEKSKDSRDHIAGYMPYVVPPLEGLWWMGRNASEPVDYARKQDFQWISMIRLPEFVTADAFEHARGLFANKHPEADVSRARLFEYDEGLCAQVMHVGPYDTEPATIAALDKFVGEHGYALDFSDARHHHEIYLSNPQRCAPDRLRTVIRHPVRMASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT66</accession>
    <name>B8DT66_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative pullulanase</fullName>
            <ecNumber evidence="3">3.2.1.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pulA</name>
        <name evidence="3" type="ordered locus">BLA_0903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.41" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0903"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29195">
        <property type="protein sequence ID" value="ACL29195"/>
        <property type="gene ID" value="BLA_0903"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0903"/>
    <dbReference type="HOGENOM" id="CLU_004744_4_1_11"/>
    <dbReference type="OMA" id="KMMRKFM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051060">
        <property type="term" value="F:pullulanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045041">
        <property type="entry name" value="Pullulanase_PULA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43631">
        <property type="entry name" value="PTHR43631"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="30"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="579" mass="64232" checksum="F7A7EB7894804A4E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT68</accession>
    <name>B8DT68_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative sugar ABC transport system membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_0905</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0905"/>
    <dbReference type="EnsemblBacteria" id="ACL29197">
        <property type="protein sequence ID" value="ACL29197"/>
        <property type="gene ID" value="BLA_0905"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0905"/>
    <dbReference type="HOGENOM" id="CLU_016047_0_3_11"/>
    <dbReference type="OMA" id="PVFSWTL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="235"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="469" mass="52370" checksum="7F3E93413A4E4255" modified="2009-03-03" version="1">MSSSVVTLSKREMKRRQKLGADYVAPSPYTLSAALKDGDVFTKLSIIFFGLGNFARHQIAKGVIFLAGEIGFIVFMIYAGAHNLAMLPSLGWRQASTEWVGAKLVHTAGDNSVLILLYGVCTLVLCAVFVLWWDLAIRSAYKAQCLAGKNGHAPSLLDDIHTLLNEKANILFLALPTLGILIFTVLPLIFMISMAFTSYDHNHLVLFDWVGFENFKTVFSNSGSIVSARLFMSVLGWTLIWAFFATFLNFFCGLFLAMVINRKTTHGKGFWRAVFSMSIAVPQFVSLLVMHQMLQPQGAINRILMNWGWIDNPMPFFTDATWARVTVIVINLWVGIPYTIMQVTGILQNIPADQYEAAEIDGANWWQIFTKITMPYIIFVLTPYLITTFTGNVNNFNVIYLLTRGDPAVVGDSAGKTDLLITWLYKLTVDNNDYNLGAVIGIMTFVVLAVVSLITYRSSGSYKNEEAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTB3</accession>
    <name>B8DTB3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sugar transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BLA_0952</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GRP transporter (TC 2.A.7.5) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217613.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29242">
        <property type="protein sequence ID" value="ACL29242"/>
        <property type="gene ID" value="BLA_0952"/>
    </dbReference>
    <dbReference type="GeneID" id="66533436"/>
    <dbReference type="KEGG" id="bla:BLA_0952"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.994"/>
    <dbReference type="HOGENOM" id="CLU_076024_0_0_11"/>
    <dbReference type="OMA" id="VNTKMGG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015144">
        <property type="term" value="F:carbohydrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010651">
        <property type="entry name" value="Sugar_transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119">
        <property type="entry name" value="PTHR16119"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06800">
        <property type="entry name" value="Sugar_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="319" mass="33759" checksum="9DD938AB0EB15561" modified="2009-03-03" version="1">MGMLIALLPALFLGSNSVMTAKIDGKPSQGTLGTTFGAFLFAVLMAVCYTIPHAGASFAFNPRIWVVGLCSGIFWTIGSIGQFSALKPLGVSLAMPISTAGQVVGNALMAAIVLGEWRSLRVWVIGIIAIILVTSGAILCSARDSVTDAVHISAKNMKFGMIALLISTIGFMMYFVFPNLLHKTGYIDNAIYNAPDGNGLYYMTAMILPQSVGQVLAAVAIIVLGEHNQSLIFTRKTALNIFTGLSWAIGNCLIFISAANPNVGQAIATTFSQLGVLVSTFGGIVILKEHKTRHQMICILFGTLLIVAGAVLMAMYTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTB7</accession>
    <name>B8DTB7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217617.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0956"/>
    <dbReference type="EnsemblBacteria" id="ACL29246">
        <property type="protein sequence ID" value="ACL29246"/>
        <property type="gene ID" value="BLA_0956"/>
    </dbReference>
    <dbReference type="GeneID" id="66533432"/>
    <dbReference type="KEGG" id="bla:BLA_0956"/>
    <dbReference type="HOGENOM" id="CLU_151863_0_0_11"/>
    <dbReference type="OMA" id="ASCFLVH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025242">
        <property type="entry name" value="DUF4193"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13834">
        <property type="entry name" value="DUF4193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="97" mass="10596" checksum="6093B67DEB2D6EE2" modified="2009-03-03" version="1">MAQDYDSPRSKDEDEESLQALGKSSQNASNDMDDDENAIAEDYELPGADLSNEDASVTVIPMQGDEFICSECFLVKHRSQLAYTTPDGQPVCKECAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTC6</accession>
    <name>B8DTC6_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="5 6">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">nadE</name>
        <name evidence="9" type="ordered locus">BLA_0965</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>ATP + deamido-NAD(+) + H2O + L-glutamine = AMP + diphosphate + H(+) + L-glutamate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="5 6"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217629.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0965"/>
    <dbReference type="EnsemblBacteria" id="ACL29255">
        <property type="protein sequence ID" value="ACL29255"/>
        <property type="gene ID" value="BLA_0965"/>
    </dbReference>
    <dbReference type="GeneID" id="66533424"/>
    <dbReference type="KEGG" id="bla:BLA_0965"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1008"/>
    <dbReference type="HOGENOM" id="CLU_022313_2_0_11"/>
    <dbReference type="OMA" id="VLMPSPY"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for glutaminase activity" evidence="5">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="For glutaminase activity" evidence="5">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutaminase activity" evidence="5">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="294"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="537"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL29255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="566" mass="61382" checksum="D504C0285E20CAE1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTF7</accession>
    <name>B8DTF7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29286">
        <property type="protein sequence ID" value="ACL29286"/>
        <property type="gene ID" value="BLA_0996"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0996"/>
    <dbReference type="HOGENOM" id="CLU_161851_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="99" mass="9982" checksum="3ECD6097A8E0C208" modified="2009-03-03" version="1">MTTTTNNMDSNNMNNGTANGGSTPGASSDGDLDFQGKADAAEKGEKGCGCNCSAKQTESREQPKSNEVRQPAEPSNPFPQSEAPSGDGTGIKAGGGQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTG7</accession>
    <name>B8DTG7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_1006</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S51 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29296">
        <property type="protein sequence ID" value="ACL29296"/>
        <property type="gene ID" value="BLA_1006"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1006"/>
    <dbReference type="HOGENOM" id="CLU_090997_0_0_11"/>
    <dbReference type="OMA" id="DFYVLPH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005320">
        <property type="entry name" value="Peptidase_S51"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03575">
        <property type="entry name" value="Peptidase_S51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="214" mass="23609" checksum="7A638C1D7C8FB246" modified="2009-03-03" version="1">MPVLRRELGPLRGVRMAFIPTASTVESYGVLVRLMRIRFALAGLRVQMVDPERMPAAQVCARLQSSDIIYVGGGNTFHLMHHLHAADADDVIRKLVREGVPYVGESAGAVVASDDISYIAPMDENRGHTRMRGLALTRFHVIPHVGSVSMGSSARRIVAMHAGQQDYVPLFNGQALVVRGHVARIASMPLVEQFRRLRNACRECMHSAGKMHVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTI3</accession>
    <name>B8DTI3_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UPF0182 protein BLA_1022</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BLA_1022</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UPF0182 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217708.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1022"/>
    <dbReference type="EnsemblBacteria" id="ACL29312">
        <property type="protein sequence ID" value="ACL29312"/>
        <property type="gene ID" value="BLA_1022"/>
    </dbReference>
    <dbReference type="GeneID" id="66533366"/>
    <dbReference type="KEGG" id="bla:BLA_1022"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1068"/>
    <dbReference type="HOGENOM" id="CLU_007733_1_0_11"/>
    <dbReference type="OMA" id="HLRYPQD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01600">
        <property type="entry name" value="UPF0182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005372">
        <property type="entry name" value="UPF0182"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39344">
        <property type="entry name" value="PTHR39344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03699">
        <property type="entry name" value="UPF0182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="11"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="968"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="968"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1022"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="1055" mass="114656" checksum="BCB4A8AF393B0AF3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTJ9</accession>
    <name>B8DTJ9_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">wblE</name>
        <name evidence="11" type="synonym">whiB</name>
        <name evidence="13" type="ordered locus">BLA_1040</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217727.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1040"/>
    <dbReference type="EnsemblBacteria" id="ACL29328">
        <property type="protein sequence ID" value="ACL29328"/>
        <property type="gene ID" value="BLA_1040"/>
    </dbReference>
    <dbReference type="GeneID" id="66533348"/>
    <dbReference type="KEGG" id="bla:BLA_1040"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1087"/>
    <dbReference type="HOGENOM" id="CLU_106245_6_2_11"/>
    <dbReference type="OMA" id="DTCLKWA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="12"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACL29328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="92" mass="10404" checksum="4A0D27B07AE13131" modified="2009-03-03" version="1">MSSAFDWRAKAACRDKDPELFFPVGNTGAAYQQIEEAKAVCRTCKVIDACLKCALDTNQDYGVWGGLSEDERRALKRRAMRARRSQSLQMQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTK3</accession>
    <name>B8DTK3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell envelope-related transcriptional attenuator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_1044</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1044"/>
    <dbReference type="EnsemblBacteria" id="ACL29332">
        <property type="protein sequence ID" value="ACL29332"/>
        <property type="gene ID" value="BLA_1044"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1044"/>
    <dbReference type="HOGENOM" id="CLU_016455_0_0_11"/>
    <dbReference type="OMA" id="ACAVKTV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="112"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="363"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="407"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="474" mass="51326" checksum="F25188899C868B53" modified="2009-03-03" version="1">MNIGGPVDEHPRHSTVQVRHVRYRILKIIAMVLVAVLVFAGSVAAATWLNINNAVQSGKIRSLIEGESDEDAYLDPNSGKPINFVLIGQDTRDGDGNGDVSGDGATEGGLHNADTTMVVQIGADRNYVNLVSIPRDSLVDVPACHTSKETIPAQYGVQFNSIFANAYSVGGDLSSAASCTVNAVNALTGLHISNFIVVDFNGLSKMIDSIDGVDLCFPSDVDDPNTNMHLKKGMHHLNGVEATNYARRRHGNDTDGSDIMRTTRQQYLIKSVLQKAISRNLFTQTSQLYQLVMNAIRSLNFSSGMADTNALMGLALSLRNLKVDHLYSQTVPIMSAPQDPNRVVWTEDAKAVWAKFKEAKPLFGSDDSAGADKQEEEQSQVSVSEEPTEPAQTEDPSPQPSDDSGSSSQEEKPRLDEKTGLLVHPDGILTDPETGGVVDPDDGSIKDPNTNQYVGISYRYLNNTICKVPEHSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTL0</accession>
    <name>B8DTL0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Arabinofuranohydrolase d3</fullName>
            <ecNumber evidence="8">3.2.1.37</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BLA_1051</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="8"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219346.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1051"/>
    <dbReference type="CAZy" id="GH43">
        <property type="family name" value="Glycoside Hydrolase Family 43"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29339">
        <property type="protein sequence ID" value="ACL29339"/>
        <property type="gene ID" value="BLA_1051"/>
    </dbReference>
    <dbReference type="GeneID" id="66532880"/>
    <dbReference type="KEGG" id="bla:BLA_1051"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1098"/>
    <dbReference type="HOGENOM" id="CLU_016508_1_0_11"/>
    <dbReference type="OMA" id="LPLVWQW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH43_C2" evidence="7">
        <location>
            <begin position="318"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="519" mass="58756" checksum="428B2254B22AAEE7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTM4</accession>
    <name>B8DTM4_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Single-stranded DNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_1065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218762.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1065"/>
    <dbReference type="EnsemblBacteria" id="ACL29353">
        <property type="protein sequence ID" value="ACL29353"/>
        <property type="gene ID" value="BLA_1065"/>
    </dbReference>
    <dbReference type="GeneID" id="66532894"/>
    <dbReference type="KEGG" id="bla:BLA_1065"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1114"/>
    <dbReference type="HOGENOM" id="CLU_078758_1_3_11"/>
    <dbReference type="OMA" id="ANTEDHG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="122"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="122"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="240" mass="26101" checksum="28A0FCE5E4247E34" modified="2009-03-03" version="1">MALQQGAVTITGYLGADPQQYGRNPSRPACTFRLGSTRRYQDRNGVWQQLPTTWLTVKAFRGLAANIMQSLHRGDPAIVTGLLNTEQWRDEQGVDHSRLVLEASNVGLDLNYVVTMSMRTPREGYTGQQAPSQMASDEQGSPMRPQTQQATSAAPQSTLSRSSMAPGDDGGNPVDPFNQMPPDCLSPDAAASMPQQGDQRDAALEPLVGNGMPPQDLEHGCATDTTNSRKEVRPEDQDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTN5</accession>
    <name>B8DTN5_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Cell division ATP-binding protein FtsE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">ftsE</name>
        <name evidence="9" type="ordered locus">BLA_1076</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the ABC transporter FtsEX involved in cellular division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Forms a membrane-associated complex with FtsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218772.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1076"/>
    <dbReference type="EnsemblBacteria" id="ACL29364">
        <property type="protein sequence ID" value="ACL29364"/>
        <property type="gene ID" value="BLA_1076"/>
    </dbReference>
    <dbReference type="GeneID" id="66532902"/>
    <dbReference type="KEGG" id="bla:BLA_1076"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1126"/>
    <dbReference type="HOGENOM" id="CLU_000604_7_0_11"/>
    <dbReference type="OMA" id="PPANEQS"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005286">
        <property type="entry name" value="Cell_div_FtsE_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02673">
        <property type="entry name" value="FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="4"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="343"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="389"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="413"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="428"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL29364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="442" mass="47958" checksum="1FAE6C6CC0E0266E" modified="2009-03-03" version="1">MALISMEHVSKIYPNAKRPALQDIDLEISRGEFVFLVGASGSGKTSLLRLLLREEEATSGEIRVGGYDLRRLPNRQVPQYRRSIGMVFQDYKLLNNKTVWENVAFALEVIGTSRSTIKSLVPKVLKTVGLTGKENNYPRELSGGEQQRVTIARAYVNHPQLLLADEPTGNLDPTTSLGIMEVLDAISRTGTTIVMATHNEEIVNSMRKRVVELNKGSIVRDEKNGSYDSAMYFPDEQVAAMSHAAIKAEVGIGAVAGSETGAVIEPATNQQKSHSGKHERDERATTMVDSVNEILQSEHSNEGIARLAQSVHAGKTGRYGEAFADVEQTLTWGGGLSLEELAEQEGIDTSKTREVSTAAKADASMEQDSGKAWGTVTLEEPRGEADSTGNASAGKTTPVEQTQAMAPVTKEIEPSTPPMPPSPPKGRHSRPRTPDEPNKDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTS7</accession>
    <name>B8DTS7_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA primase</fullName>
            <ecNumber evidence="12">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">dnaG</name>
        <name evidence="15" type="ordered locus">BLA_1118</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with DnaB.</text>
    </comment>
    <comment type="domain">
        <text evidence="12">Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DnaG primase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="12"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619937.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1118"/>
    <dbReference type="EnsemblBacteria" id="ACL29406">
        <property type="protein sequence ID" value="ACL29406"/>
        <property type="gene ID" value="BLA_1118"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1118"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1171"/>
    <dbReference type="HOGENOM" id="CLU_013501_3_1_11"/>
    <dbReference type="OMA" id="LMWPIRD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00974">
        <property type="entry name" value="DNA_primase_DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019475">
        <property type="entry name" value="DNA_primase_DnaB-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006295">
        <property type="entry name" value="DNA_primase_DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030846">
        <property type="entry name" value="DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10410">
        <property type="entry name" value="DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01391">
        <property type="entry name" value="dnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 12" id="KW-0639">Primosome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="14">
        <location>
            <begin position="263"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CHC2-type" evidence="12">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="460"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="603"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ACL29406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="693" mass="76665" checksum="755087F210A2789B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTS8</accession>
    <name>B8DTS8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Possible transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BLA_1119</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218836.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1119"/>
    <dbReference type="EnsemblBacteria" id="ACL29407">
        <property type="protein sequence ID" value="ACL29407"/>
        <property type="gene ID" value="BLA_1119"/>
    </dbReference>
    <dbReference type="GeneID" id="66532942"/>
    <dbReference type="KEGG" id="bla:BLA_1119"/>
    <dbReference type="HOGENOM" id="CLU_063025_0_0_11"/>
    <dbReference type="OMA" id="ICSMFVT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="CitMHS" evidence="7">
        <location>
            <begin position="17"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="397" mass="43466" checksum="4545D73B7423B92E" modified="2009-03-03" version="1">MRHRVGAFLRGETILIVATLLALISCFIVPPDWHYREYVHVSTIAQLICLMLVVCGLQRVGVFRIIGAKLLEHVDTARGLVLTFISLTFFSSMLITNDVALLTFVPFALAVLKMAKMEDRAILVCTLMTIGANTGSMLTPIGNAHNLYFKALTGMSTGHFLAVMGPYTAVSAAMLIAITCIVFRGRRLEGISGMDSKSIEHGVLAPDSTKPQPDEIHVTGYGAGYGGWRVIVYAITFIVCVLAVGDLIPLWVMCVVVFAVMMVCDRRSFRHADWGLPLTFIMFFIFIGNMRRVPEFAQLAQQCVGVHPLGVSILFSQVISNVPTSLLLAGFSNAYVPLIIGTNLGGLGTLIASMASLVTYKHFTKMYPNQKGKYLKEYTSFCALFVLVLFGLSCILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTU0</accession>
    <name>B8DTU0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1131"/>
    <dbReference type="EnsemblBacteria" id="ACL29419">
        <property type="protein sequence ID" value="ACL29419"/>
        <property type="gene ID" value="BLA_1131"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1131"/>
    <dbReference type="HOGENOM" id="CLU_713060_0_0_11"/>
    <dbReference type="OMA" id="AVFHGRI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="26"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="409" mass="43396" checksum="5CB798A3E9A0081C" modified="2009-03-03" version="1">MAYDNGNVIDVRANTTLSTENAIKGNVLVLGNSGVGKSTLINAVIGDTVAKTSFGTRGTTSELAVYESPTVPFRVIDSIGFEPSPIKSLRAVHAVRKWSKASAKEGHEHNKIDVIWFCVDGTAAKLFPETIRNLSTAVSMWRSVPIITVITKSYSKPDRELNVQMVRQAFAGQRMERNLRAIIPVVAQTYVIDETAFAGPEGISDLIDETMKAMPEGMRGGSHDLMAFKLTRKRVLAQGLIGACVAAGATVGAVPIPIADSLVLSPLELGELHGLARLYGIDKDEGSKQFLDSIVQVGTASVVAHSAISAVKSIPGVNIAASVLNAIVAASIIAALGEGAVIAFEQVYSGKRSVNDVTWVQNLMQEQFGEGFLGKVSGVAQASAKAGDAKDMREMIVELVKAAFMNRGE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTV6</accession>
    <name>EFG_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor G</fullName>
            <shortName evidence="1">EF-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fusA</name>
        <name type="ordered locus">BLA_1147</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269068.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DTV6"/>
    <dbReference type="SMR" id="B8DTV6"/>
    <dbReference type="STRING" id="442563.BLA_1147"/>
    <dbReference type="EnsemblBacteria" id="ACL29435">
        <property type="protein sequence ID" value="ACL29435"/>
        <property type="gene ID" value="BLA_1147"/>
    </dbReference>
    <dbReference type="GeneID" id="66532972"/>
    <dbReference type="KEGG" id="bla:BLA_1147"/>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_11"/>
    <dbReference type="OMA" id="AATTCHW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000201440" description="Elongation factor G">
        <location>
            <begin position="1"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="10"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="91"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="145"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <sequence length="709" mass="78551" checksum="04C26C7F7E0EA423" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTW2</accession>
    <name>B8DTW2_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbamoyl-phosphate synthase small chain</fullName>
            <ecNumber evidence="2">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Carbamoyl-phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">carA</name>
        <name evidence="4" type="ordered locus">BLA_1153</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1153"/>
    <dbReference type="EnsemblBacteria" id="ACL29441">
        <property type="protein sequence ID" value="ACL29441"/>
        <property type="gene ID" value="BLA_1153"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1153"/>
    <dbReference type="HOGENOM" id="CLU_035901_2_1_11"/>
    <dbReference type="OMA" id="CFNTGMT"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSase_sm_chain" evidence="3">
        <location>
            <begin position="13"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="410" mass="44509" checksum="7C014E0DF05D283D" modified="2009-03-03" version="1">MTQFDPANEYTAQDAVLVLEDGQVYVGEPFGATGSTCAEIVFNTAMTGYQETLTDPSYDRQIVVQTFPHIGDTGVNDDDLESSRIWVAGYVVRDPSMVVSNWRAAGSLDDDLMANHIVGISHIDTRKLVRHLRSAGVMRAGIFSGAALVGSNGEPREISDMLEEVQRTPQMKGMSLYDEVSTPEAYVVEPAGDFEGKEPLFTVAAVDLGIKAMTPHRMAERGCRVVVLPSTVTFDEIQELNPDGVFFSNGPGDPEQAGQMVSLLRQVLDAGYPFFGICFGNQLLGRALGFGTYKLKFGHRGINQPVKDVTTGKVEVTAHNHGFAVDAPIGETVDAPFENGRYGKVFVSHVDLNDNVVEGLQCVDIPAFSVQYHPEAAAGPHDAAYLFDRFVSMMDNSRDSKASKEENANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTY9</accession>
    <name>B8DTY9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MoxR-like ATPases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_1180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619956.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1180"/>
    <dbReference type="EnsemblBacteria" id="ACL29468">
        <property type="protein sequence ID" value="ACL29468"/>
        <property type="gene ID" value="BLA_1180"/>
    </dbReference>
    <dbReference type="GeneID" id="66533005"/>
    <dbReference type="KEGG" id="bla:BLA_1180"/>
    <dbReference type="HOGENOM" id="CLU_034716_2_0_11"/>
    <dbReference type="OMA" id="YPIPEPF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="2">
        <location>
            <begin position="68"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="3">
        <location>
            <begin position="281"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="354" mass="38372" checksum="396C501A305A12C3" modified="2009-03-03" version="1">MSFFSPSQPTAPPPVPSTLQSPTVPISRNDAERAGRLVDSIRSRFAQTLVGQTNLRESLITTLVAGGHILIESVPGLAKTTAAQTLATSVSGSFKRVQCTPDLMPSDLVGTQVFDFSTQRFTTQIGPIHANFVLLDEINRANAKTQSAMLEAMAEGATTIGGQRIELPKPFMVIATQNPIEEEGTFNLPEAQMDRFMMKAIMTYPSADEEQRMLGLLINRGSDAIDPTKLPRDVISIQDVDWLRETARRVHVSDAIMQYAVALSETSRGGGPKPIQGLSSLVRLGASPRASIALVRIAQASALMAGRDYVIPEDVRGFAHEVFRHRILLTFEALADGVTSDQIVDQIVQVVPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTZ4</accession>
    <name>B8DTZ4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218163.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1185"/>
    <dbReference type="EnsemblBacteria" id="ACL29473">
        <property type="protein sequence ID" value="ACL29473"/>
        <property type="gene ID" value="BLA_1185"/>
    </dbReference>
    <dbReference type="GeneID" id="66533011"/>
    <dbReference type="KEGG" id="bla:BLA_1185"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1246"/>
    <dbReference type="HOGENOM" id="CLU_061736_0_0_11"/>
    <dbReference type="OMA" id="VITMWIT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="335" mass="35936" checksum="D5B47A3985E18511" modified="2009-03-03" version="1">MANNNEWTAQQAIVVGGRGDDPVIVDNFGGLKRQARVWTAVLSVIMLFAALLVGATGAQMAAADDSPSPSASESSSPSALVEDSQGYITDPQNLLGDNLTKVIDAANRTKQETGVTVRLLYLESFNTTEKPEQWASQLLESLNPPANTVMLAVASHDGNLVVVVSPNSDEWLRSQSTVDQLSEAASKPLLDQQAGQGPNWSQSAIDMMDAIASAKSTATTHAVSSVSIIVMIIVFVVLIVVVLVMIFMRRKREVSEGSKQTEEVGKTRNDDAMQLDNADDDLDVTAMAPEETSEQPEGKEAQEPNPTSEASGMPAPRRGRHAAAPHDDERFKRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTZ6</accession>
    <name>B8DTZ6_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BLA_1187</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1187"/>
    <dbReference type="EnsemblBacteria" id="ACL29475">
        <property type="protein sequence ID" value="ACL29475"/>
        <property type="gene ID" value="BLA_1187"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1187"/>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_11"/>
    <dbReference type="OMA" id="FSDHGPG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="231"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="299"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL29475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="573" mass="62062" checksum="B76916307361B994" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTZ7</accession>
    <name>B8DTZ7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cold shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cspB</name>
        <name evidence="2" type="ordered locus">BLA_1188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218160.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1188"/>
    <dbReference type="EnsemblBacteria" id="ACL29476">
        <property type="protein sequence ID" value="ACL29476"/>
        <property type="gene ID" value="BLA_1188"/>
    </dbReference>
    <dbReference type="GeneID" id="66533014"/>
    <dbReference type="KEGG" id="bla:BLA_1188"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1249"/>
    <dbReference type="HOGENOM" id="CLU_125944_0_0_11"/>
    <dbReference type="OMA" id="QRVEFGM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="129" mass="13971" checksum="5FD9425DFD762619" modified="2009-03-03" version="1">MPSGRIRWFDAKKGYGFIAGDDGKDVFLPQTALPQGVRNPRKGAKVEYSVIEGNRGQVAMGVTMVASAPSLVKATRPKPDDMAAIVEDLIKLLDSAGNGLRRHRYPSSADSRKLATLLRAVADDFDVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU27</accession>
    <name>B8DU27_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative polyphosphate glucokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ppgK</name>
        <name evidence="1" type="ordered locus">BLA_1218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218121.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1218"/>
    <dbReference type="EnsemblBacteria" id="ACL29506">
        <property type="protein sequence ID" value="ACL29506"/>
        <property type="gene ID" value="BLA_1218"/>
    </dbReference>
    <dbReference type="GeneID" id="66533042"/>
    <dbReference type="KEGG" id="bla:BLA_1218"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1280"/>
    <dbReference type="HOGENOM" id="CLU_065796_0_0_11"/>
    <dbReference type="OMA" id="HVEMLFS"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="256" mass="27261" checksum="866246E32E1391C6" modified="2009-03-03" version="1">MIDTAQAFGVDIGGSGIKAAPVNLEKGEFAEPRLKILTPEHSTPKAVGDIVRQQLEHFEVPEDVPVGIAFPAPIKPGKKLDFMANLDQSWIGVDVTEVFSEACGRPVTVVNDADAAGLAEQAFGAAAGQDGLVIATTLGTGIGTALIYDGVLIPNTELGHIQLPKGKGDAEKYAASSVREKLDMGYRKWAKRLTKYYGLMELYFSPELFVVGGGVSRVSEKFLPYIDIKTPIVAAKLHNEAGIVGAAYYANQQSAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU32</accession>
    <name>DNLJ_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA ligase</fullName>
            <ecNumber evidence="1">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ligA</name>
        <name type="ordered locus">BLA_1223</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide.</text>
            <dbReference type="EC" id="6.5.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218116.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DU32"/>
    <dbReference type="SMR" id="B8DU32"/>
    <dbReference type="STRING" id="442563.BLA_1223"/>
    <dbReference type="EnsemblBacteria" id="ACL29511">
        <property type="protein sequence ID" value="ACL29511"/>
        <property type="gene ID" value="BLA_1223"/>
    </dbReference>
    <dbReference type="GeneID" id="66533047"/>
    <dbReference type="KEGG" id="bla:BLA_1223"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1285"/>
    <dbReference type="HOGENOM" id="CLU_007764_2_1_11"/>
    <dbReference type="OMA" id="HDVEHEI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00114">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DisA/LigA_HHH"/>
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        <property type="entry name" value="DNA_ligase_AS"/>
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        <property type="entry name" value="DNA_ligase_CS"/>
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    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
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        <property type="entry name" value="DNAligase_adenylation"/>
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        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004149">
        <property type="entry name" value="Znf_DNAligase_C4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03119">
        <property type="entry name" value="DNA_ligase_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="2"/>
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    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
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        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01055">
        <property type="entry name" value="DNA_LIGASE_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01056">
        <property type="entry name" value="DNA_LIGASE_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000380307" description="DNA ligase">
        <location>
            <begin position="1"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="781"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="1">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="76"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="125"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="863" mass="95953" checksum="015FB8139C31BA24" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU85</accession>
    <name>B8DU85_BIFA0</name>
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        <recommendedName>
            <fullName evidence="9">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="9">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 15" type="primary">leuS</name>
        <name evidence="15" type="ordered locus">BLA_1277</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="9"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011835.1"/>
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        <property type="protein sequence ID" value="ACL29564"/>
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    <dbReference type="GeneID" id="66533102"/>
    <dbReference type="KEGG" id="bla:BLA_1277"/>
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    <dbReference type="HOGENOM" id="CLU_004427_0_0_11"/>
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    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="3"/>
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    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
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    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
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    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
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    <dbReference type="InterPro" id="IPR014729">
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        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="13">
        <location>
            <begin position="73"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1_2" evidence="14">
        <location>
            <begin position="310"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="12">
        <location>
            <begin position="838"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="583"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="761"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="588"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="764"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ACL29564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="988" mass="111206" checksum="E8007DBC59404768" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU97</accession>
    <name>B8DU97_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter (Substrate-binding protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_1289</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218024.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1289"/>
    <dbReference type="EnsemblBacteria" id="ACL29576">
        <property type="protein sequence ID" value="ACL29576"/>
        <property type="gene ID" value="BLA_1289"/>
    </dbReference>
    <dbReference type="GeneID" id="66533115"/>
    <dbReference type="KEGG" id="bla:BLA_1289"/>
    <dbReference type="HOGENOM" id="CLU_534930_0_0_11"/>
    <dbReference type="OMA" id="NGKQWMT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870887" evidence="2">
        <location>
            <begin position="29"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="3">
        <location>
            <begin position="180"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="504" mass="53988" checksum="7906E612A314EA9D" modified="2009-03-03" version="1">MGKGTSHIIRAFVSLAMAGSLMCATAGCSTDPLTGTATTSPSATTAASTGHVALFLPSNSPNLSQNVPLNNWNTLNDSLENALSTGGFSGKSMNRETSGSLASQSDALKRYVQERLNADSKEQYGDPQTEQGATTIVIAPAVRLDRNYGEYSHFITTPNQEPSDQDASDTDSDESSSMRQIADSLNKAKNAGMHVVVLGNPIDGFVPNVYVPLVTAADIGRMQAQQIVSKLDLDAVSESNPKAIEVLLPNTDPSGKNNSFQAQAFEGIWEVLGPYFRQRKAYSPSQRLSFFTTKSDYKDVMFKATKDSQIEDELKSRLETKGRDAAVRIDGILAMNDFTAAASIKALKTMGYSGSSMDVNPSITIFDVVGNIAGRKPLNRQRVPDPAQSGDESAQPSQTTKTDSKQWPIITGFGAYISDIPNIVNGLQWMTGLVDVHANTGTIAQIALQLNRKEKLSNIAELKTSDDYGSEIPTLHMTLLAVSAANLKAALIDPGYISLADADM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUA3</accession>
    <name>RS2_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsB</name>
        <name type="ordered locus">BLA_1295</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218012.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DUA3"/>
    <dbReference type="SMR" id="B8DUA3"/>
    <dbReference type="STRING" id="442563.BLA_1295"/>
    <dbReference type="EnsemblBacteria" id="ACL29582">
        <property type="protein sequence ID" value="ACL29582"/>
        <property type="gene ID" value="BLA_1295"/>
    </dbReference>
    <dbReference type="GeneID" id="66533121"/>
    <dbReference type="KEGG" id="bla:BLA_1295"/>
    <dbReference type="HOGENOM" id="CLU_040318_2_3_11"/>
    <dbReference type="OMA" id="SYIDRAY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_S2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_S2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="PTHR12534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000194319" description="30S ribosomal protein S2">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="303" mass="33776" checksum="2E11ED385B157CCD" modified="2009-03-03" version="1">MAQITMSEMLKAGLQFGHQTRRWNPKMKQYILTERNGIYIINLFKTLDLIDVAYDFIKTTVAHNGTVLFVGTKKQAQEAIKNAATRVNMPYVSERWLGGMLTNFQTVSKRVNRLKELETMDFDDVHGSGLTKKELLLLKREKDKLERQLGGIRNMTRTPSAMFVVDINKEALAVEEAHKLGIPVVAIVDTNADPEAVEYPIPANDDAIRGIELLTNLFADAVAEGLLERSGNASKSESNSEQPMAAWEKELLEKNEKATLRENAVVTENEVKKTDEEEGASSEAARADAQNEEAVAKPGEEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUB7</accession>
    <name>B8DUB7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RAN-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217995.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29596">
        <property type="protein sequence ID" value="ACL29596"/>
        <property type="gene ID" value="BLA_1309"/>
    </dbReference>
    <dbReference type="GeneID" id="66533134"/>
    <dbReference type="KEGG" id="bla:BLA_1309"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1371"/>
    <dbReference type="HOGENOM" id="CLU_2285958_0_0_11"/>
    <dbReference type="OMA" id="HMEEKHE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="101" mass="11548" checksum="9CFCB66E10BF9B15" modified="2009-03-03" version="1">MADIKEHFEEFKDRMEEKHEEHKAERDEKRAERAEDHAAKVIAKEDEKIVKAADDPDAKLEKITDKADDKKDKAEGKAAAKEAKATEDQVELNERFGTQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUC8</accession>
    <name>B8DUC8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Possible signal transduction protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">garA</name>
        <name evidence="3" type="ordered locus">BLA_1320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217981.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1320"/>
    <dbReference type="EnsemblBacteria" id="ACL29607">
        <property type="protein sequence ID" value="ACL29607"/>
        <property type="gene ID" value="BLA_1320"/>
    </dbReference>
    <dbReference type="GeneID" id="66533145"/>
    <dbReference type="KEGG" id="bla:BLA_1320"/>
    <dbReference type="HOGENOM" id="CLU_108862_1_0_11"/>
    <dbReference type="OMA" id="IGKFRLT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="68"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="146" mass="15981" checksum="BC83A0344C71A85F" modified="2009-03-03" version="1">MTDPIPSAGETTIIGMPAIQIPVTTSGERPLTQEDLQTISRLADDTALLIATRGALSGSRYLLDEDEVTVGRDPRADILLDDSTVSRQHAVFRRENGAYTVIDAGSLNGTYVNRQRVDKATLKNGDEIMIGKFRLIYFTNSAVRNI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUF9</accession>
    <name>UPPP_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="1">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Bacitracin resistance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">uppP</name>
        <name type="ordered locus">BLA_1353</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text>Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UppP family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217939.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DUF9"/>
    <dbReference type="SMR" id="B8DUF9"/>
    <dbReference type="STRING" id="442563.BLA_1353"/>
    <dbReference type="EnsemblBacteria" id="ACL29638">
        <property type="protein sequence ID" value="ACL29638"/>
        <property type="gene ID" value="BLA_1353"/>
    </dbReference>
    <dbReference type="GeneID" id="66533184"/>
    <dbReference type="KEGG" id="bla:BLA_1353"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1416"/>
    <dbReference type="HOGENOM" id="CLU_060296_1_0_11"/>
    <dbReference type="OMA" id="IEGPFRD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00753">
        <property type="entry name" value="undec_PP_bacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0046">Antibiotic resistance</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_1000148801" description="Undecaprenyl-diphosphatase">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <sequence length="295" mass="31934" checksum="3C13781C247D6E4F" modified="2009-03-03" version="1">MNFFQAIFLGLVQALTEYLPVSSSAHVRIVGDLMLGGDPGAAFTAIIQIGTELAVLLYFRRDIWNILKSWCLCLAGKEGKDRASRFGAHNKDARLGWYIIIATIPILIAGVLFQHAIETTLRNLWITVAMLFIFGVILWIVDDRARQVKTLDDMNTKDAIWFGIGQMLALIPGVSRSGGTITFGRAMGYKREAAVRAAFLMAIPAVFGAGILEAVKAIKDVNADAMFPGWGATIAATVVAFVVGYIVIIGFLKFVSTYSYKAFAIYRIALAIIVAILLLCGVLSPLEGIPVSGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUI8</accession>
    <name>B8DUI8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin reductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_1382</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217903.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1382"/>
    <dbReference type="EnsemblBacteria" id="ACL29667">
        <property type="protein sequence ID" value="ACL29667"/>
        <property type="gene ID" value="BLA_1382"/>
    </dbReference>
    <dbReference type="GeneID" id="66533212"/>
    <dbReference type="KEGG" id="bla:BLA_1382"/>
    <dbReference type="HOGENOM" id="CLU_031864_5_4_11"/>
    <dbReference type="OMA" id="VAYCSTC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017561">
        <property type="entry name" value="AhpF_homologue_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13192">
        <property type="entry name" value="Thioredoxin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03143">
        <property type="entry name" value="AhpF_homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="7"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="3">
        <location>
            <begin position="509"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="590" mass="63617" checksum="1CDAE6572CC00350" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUK8</accession>
    <name>B8DUK8_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA (adenine(58)-N(1))-methyltransferase TrmI</fullName>
            <ecNumber evidence="4">2.1.1.220</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pimT</name>
        <name evidence="6" type="ordered locus">BLA_1402</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenosine(58) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10365"/>
            <dbReference type="Rhea" id="RHEA-COMP:10366"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
            <dbReference type="EC" id="2.1.1.220"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer composed of a dimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="4"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217880.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1402"/>
    <dbReference type="EnsemblBacteria" id="ACL29687">
        <property type="protein sequence ID" value="ACL29687"/>
        <property type="gene ID" value="BLA_1402"/>
    </dbReference>
    <dbReference type="GeneID" id="66533231"/>
    <dbReference type="KEGG" id="bla:BLA_1402"/>
    <dbReference type="HOGENOM" id="CLU_025402_0_0_11"/>
    <dbReference type="OMA" id="VVYPKDA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016429">
        <property type="term" value="F:tRNA (adenine-N1-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="PTHR12133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR017269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="352" mass="39532" checksum="D4FD3358EE3ADF4B" modified="2009-03-03" version="1">MRRGPLQSGEKVQFTDRKSNKITDQLVAGGVTQTSHGIILHDDVIGRNEGSVVTTVTAKREDQFNREHPERDTAKPWKAARAIGGWQFAVMRPRMADYVLSMPRGAQIMYPKDIAQVIELGDIRSGARVLESGAGSGAMSLHLLDAVGEGGCLTTIEMRPDFARIAEANATLYYGRRPDWWNLLVGDFDSVASTLPEQGFDRIMLDMLDPWNRLEQAYRVIAPGGVLVAYVTTTTQMSRMAEALRESEHWTAPQIQETMERNWKAQGLAVRPDHQMIGHTGFLIVSRAMAPGYDALRKRDRATKDTTTDIDSLSVEEREASLEELELRDISDRKLRKVLRDLDEQRSHLDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUQ1</accession>
    <name>B8DUQ1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1446"/>
    <dbReference type="EnsemblBacteria" id="ACL29730">
        <property type="protein sequence ID" value="ACL29730"/>
        <property type="gene ID" value="BLA_1446"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1446"/>
    <dbReference type="HOGENOM" id="CLU_061953_0_0_11"/>
    <dbReference type="OMA" id="YDTEKEH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="337" mass="38680" checksum="696AEE12DD09386C" modified="2009-03-03" version="1">MCSGNSKPYDTEKEHIMENNNPPIRFFEMLGLSEEELSEYAIRLNQSSGAWFDAMTMYYEHHDELMDWVFTRRWNGSKAGGNIRQPKVLQFIQLDGREKPAIHWLFIGGYEVGETVMQGNDEVYQRKPIERFLPFEARTVVVYRKRRGATQMVNGMADAGLRSRFFDTMLVEKIAQSPVSAMPFPGYDNVRLSFSELVAAVHNDEWRGALGAVNAVYLQTDTRTGWHYVGSAYSRHGGAQGLLSRWEEYANGDHTGGNALLKDLVAKHGVEYIEQYFQYSILDIFDPRVPDRTVIEREHWWMDALSSVRDDRASSPHGYNSKLQWNRTSEGREAGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUQ6</accession>
    <name>B8DUQ6_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endolytic murein transglycosylase</fullName>
            <ecNumber evidence="7">4.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerization terminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mltG</name>
        <name evidence="9" type="ordered locus">BLA_1451</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transglycosylase MltG family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="7"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217817.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1451"/>
    <dbReference type="EnsemblBacteria" id="ACL29735">
        <property type="protein sequence ID" value="ACL29735"/>
        <property type="gene ID" value="BLA_1451"/>
    </dbReference>
    <dbReference type="GeneID" id="66533281"/>
    <dbReference type="KEGG" id="bla:BLA_1451"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1517"/>
    <dbReference type="HOGENOM" id="CLU_025574_4_0_11"/>
    <dbReference type="OMA" id="TDWDPGP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08010">
        <property type="entry name" value="MltG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02065">
        <property type="entry name" value="MltG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00247">
        <property type="entry name" value="TIGR00247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="11"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL29735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="393" mass="43681" checksum="D87D712B70DD66EA" modified="2009-03-03" version="1">MSDDLHDFFNADESWDDGAEPAAMPPAPPHSRREMRRQRAMRKRRNLIICIIVVIALALISVGGVFAYRAARNWRRTNMAHESLVEDYPGPGDTDVAFTVKQGEGIMEVGANLVQQQIVKSADTFATYVSSNDKTLYPGTYALKTHMKASQAADILSDQGNAKGFAEVRQGERVSTVIERICADNDIDKTRFEAIVNNRDEASKILPAEANGNFEGWLEPGTYTVGDVATAPERLLKEMVDARIRKLDEMGVPQGAERERMLIIASIVEAEVNSSDYYSKVSRVIYNRLDKDMTLGMDSTVAYGASINGMQLTNDQLQDTSNPYNTRVNRGLPPTPISNPGDDAIEAAMHPADGNWLYFVTTDLKTGETKFADTDEQFQQLVQEYRRNNPDAN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUR4</accession>
    <name>XPT_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Xanthine phosphoribosyltransferase</fullName>
            <shortName evidence="1">XPRTase</shortName>
            <ecNumber evidence="1">2.4.2.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">xpt</name>
        <name type="ordered locus">BLA_1460</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine</text>
            <dbReference type="Rhea" id="RHEA:10800"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.22" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217806.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DUR4"/>
    <dbReference type="SMR" id="B8DUR4"/>
    <dbReference type="STRING" id="442563.BLA_1460"/>
    <dbReference type="EnsemblBacteria" id="ACL29743">
        <property type="protein sequence ID" value="ACL29743"/>
        <property type="gene ID" value="BLA_1460"/>
    </dbReference>
    <dbReference type="GeneID" id="66533290"/>
    <dbReference type="KEGG" id="bla:BLA_1460"/>
    <dbReference type="HOGENOM" id="CLU_099015_0_0_11"/>
    <dbReference type="OMA" id="HQVDPVL"/>
    <dbReference type="UniPathway" id="UPA00602">
        <property type="reaction ID" value="UER00658"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000310">
        <property type="term" value="F:xanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046110">
        <property type="term" value="P:xanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032265">
        <property type="term" value="P:XMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01184">
        <property type="entry name" value="XPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010079">
        <property type="entry name" value="Xanthine_PRibTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01744">
        <property type="entry name" value="XPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0660">Purine salvage</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000164447" description="Xanthine phosphoribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>xanthine</name>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>xanthine</name>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="129"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>xanthine</name>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01184"/>
        </source>
    </evidence>
    <sequence length="193" mass="21073" checksum="272C76F5FEEBC433" modified="2009-03-03" version="1">MQELEERIREQGVVKPGNVLKVDAFLNHQCDVRLFDHMGAAWAEHFNNKHITKILTIEASGIGIACVAATHFDDVPVVFAKKAQSINLDGEQYVTHVYSFTKQKEFPVIVSKKYLNAGDRVLLIDDFLANGKALNGLIELCESAGAIVEGIGIAIEKGFQGGGDALREAGYDLDSLAIVESMDAETGAIEFRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUR6</accession>
    <name>B8DUR6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29745">
        <property type="protein sequence ID" value="ACL29745"/>
        <property type="gene ID" value="BLA_1462"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1462"/>
    <dbReference type="HOGENOM" id="CLU_2731884_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="71" mass="7623" checksum="D68DEEAE620F9411" modified="2009-03-03" version="1">MYLIQYACGTCGFLDFVVASFEVGIIGMRVGNGICNLPPCEMRGADGITPSAPRIQSGFFPIPFTSGWSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUU3</accession>
    <name>B8DUU3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NGG1-interacting factor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217759.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1490"/>
    <dbReference type="EnsemblBacteria" id="ACL29772">
        <property type="protein sequence ID" value="ACL29772"/>
        <property type="gene ID" value="BLA_1490"/>
    </dbReference>
    <dbReference type="GeneID" id="66533321"/>
    <dbReference type="KEGG" id="bla:BLA_1490"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1559"/>
    <dbReference type="HOGENOM" id="CLU_037423_1_2_11"/>
    <dbReference type="OMA" id="ISMHTNF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="PTHR13799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="311" mass="33844" checksum="285168E006C3D4F8" modified="2009-03-03" version="1">MATVYDVMGALETLYPLRYAEDWDHPGLIVGDLRNTVNNIVFAADPTMEVVEDAIASGADMLVTHHPLFFRAVHEVSGRTFRGRIVNLLAKHDCALWVGHTNADAAYRGVAQAAADAFGLENQAPIVPIDDPTSSHTVGIGRFGRLGTPTTLERFATLVAQVLPFTKYGIQVAGPLDMPIRTVAVLPGSGDSMFANVHALHADVYVTSDLRHHPATDELQESYYEASMRREGIGLGGPSDCPHMRPALINTPHSAIESMWFNYALEDVPRMVQEVTGDIIDVRWNTTSTDPWDLVLPGVCGHPDPSPEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUX2</accession>
    <name>B8DUX2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014482450.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1519"/>
    <dbReference type="CAZy" id="GH36">
        <property type="family name" value="Glycoside Hydrolase Family 36"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29801">
        <property type="protein sequence ID" value="ACL29801"/>
        <property type="gene ID" value="BLA_1519"/>
    </dbReference>
    <dbReference type="GeneID" id="66533916"/>
    <dbReference type="KEGG" id="bla:BLA_1519"/>
    <dbReference type="HOGENOM" id="CLU_031177_0_0_11"/>
    <dbReference type="OMA" id="SGMEHYE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008811">
        <property type="entry name" value="Glycosyl_hydrolases_36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31268">
        <property type="entry name" value="PTHR31268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05691">
        <property type="entry name" value="Raffinose_syn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="630" mass="70669" checksum="A455E1794ACFAA57" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV42</accession>
    <name>B8DV42_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative beta-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_0039</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619613.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0039"/>
    <dbReference type="CAZy" id="GH3">
        <property type="family name" value="Glycoside Hydrolase Family 3"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28343">
        <property type="protein sequence ID" value="ACL28343"/>
        <property type="gene ID" value="BLA_0039"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0039"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.42"/>
    <dbReference type="HOGENOM" id="CLU_004542_4_1_11"/>
    <dbReference type="OMA" id="GGRPYNL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="4">
        <location>
            <begin position="582"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="749" mass="81437" checksum="CBFEE40CC0644425" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV59</accession>
    <name>B8DV59_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-ribulose-5-phosphate 4-epimerase</fullName>
            <ecNumber evidence="2">5.1.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">araD</name>
        <name evidence="2" type="ordered locus">BLA_0057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.3.4" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219338.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0057"/>
    <dbReference type="EnsemblBacteria" id="ACL28360">
        <property type="protein sequence ID" value="ACL28360"/>
        <property type="gene ID" value="BLA_0057"/>
    </dbReference>
    <dbReference type="GeneID" id="66532433"/>
    <dbReference type="KEGG" id="bla:BLA_0057"/>
    <dbReference type="HOGENOM" id="CLU_006033_3_0_11"/>
    <dbReference type="OMA" id="PIFGTTH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008742">
        <property type="term" value="F:L-ribulose-phosphate 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="20"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="230" mass="24979" checksum="F4872D418C77F91C" modified="2009-03-03" version="1">MATLADYGPEVRAEVKQVREVVAALHEQLIKWNLVVWTAGNVSQRLRTADLMVIKPSGLRYEYLTPSSMVVCDLDGNVVDGAESPSSDTASHAYIYRHMPEVYGVVHTHSTYATAWAATGQNIPCGLTMMGDEFGGPVPVGPFRLIGSEAIGEGVVETLKAYPKSPAVLMQNHGPFTIGKDAEAAVKAAAMTEEVAHTMWAAKQLGDIIPIPQEDIDKLNDRYQNVYGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV62</accession>
    <name>B8DV62_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoenolpyruvate carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ppc</name>
        <name evidence="8" type="ordered locus">BLA_0060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>oxaloacetate + phosphate = hydrogencarbonate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:28370"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.31"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219341.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0060"/>
    <dbReference type="EnsemblBacteria" id="ACL28363">
        <property type="protein sequence ID" value="ACL28363"/>
        <property type="gene ID" value="BLA_0060"/>
    </dbReference>
    <dbReference type="GeneID" id="66532436"/>
    <dbReference type="KEGG" id="bla:BLA_0060"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.65"/>
    <dbReference type="HOGENOM" id="CLU_006557_2_0_11"/>
    <dbReference type="OMA" id="PWVFGWT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008964">
        <property type="term" value="F:phosphoenolpyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021135">
        <property type="entry name" value="PEP_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018129">
        <property type="entry name" value="PEP_COase_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033129">
        <property type="entry name" value="PEPCASE_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30523">
        <property type="entry name" value="PTHR30523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00311">
        <property type="entry name" value="PEPcase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00150">
        <property type="entry name" value="PEPCARBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00781">
        <property type="entry name" value="PEPCASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00393">
        <property type="entry name" value="PEPCASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="918" mass="102979" checksum="AD634F99342D4DFE" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV86</accession>
    <name>B8DV86_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysophospholipase L2 PLDB</fullName>
            <ecNumber evidence="2">3.1.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.5" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218381.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0084"/>
    <dbReference type="ESTHER" id="biflb-c6a5u1">
        <property type="family name" value="Monoglyceridelipase_lysophospholip"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28387">
        <property type="protein sequence ID" value="ACL28387"/>
        <property type="gene ID" value="BLA_0084"/>
    </dbReference>
    <dbReference type="GeneID" id="66532459"/>
    <dbReference type="KEGG" id="bla:BLA_0084"/>
    <dbReference type="HOGENOM" id="CLU_026209_10_0_11"/>
    <dbReference type="OMA" id="AFDWRGQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102545">
        <property type="term" value="F:phosphatidyl phospholipase B activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="78"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="361" mass="40568" checksum="9751EA872CC17D2B" modified="2009-03-03" version="1">MEIAMINEHEFQQDLEATALPALDSCMHDGYMDPAVSDWHGHRLRTLHPADGTPNKLHVVRYDVEKFHALQIPGSSRQTHGTVLISHGFTEFAAKYKEMAWYFLLAGFSVCILEHRGHGYSARDVRNDQIVYIDTWHRYVADLAKCARTIARPMAADKPLVLFAHSMGGGIAAAMLERYPNIVDKAVLSSPMIEANLHTPNWLAALVCGAACDFGHAKSMAPGQRAFTPLIDIKDNQGACMQRLEWMKKLRIADTHYQTSAAANEWVRQAIRLSIAMQDPHMCERIETPILLFQAGNDHWVRNKAQNRFVKRVGKDGGDIRMVRVPGSVHEIFTMPNSVMAPYLKEILTFLQTSEPVTVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV94</accession>
    <name>B8DV94_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Possible alpha beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218389.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0092"/>
    <dbReference type="EnsemblBacteria" id="ACL28395">
        <property type="protein sequence ID" value="ACL28395"/>
        <property type="gene ID" value="BLA_0092"/>
    </dbReference>
    <dbReference type="GeneID" id="66532468"/>
    <dbReference type="KEGG" id="bla:BLA_0092"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.98"/>
    <dbReference type="HOGENOM" id="CLU_045011_9_1_11"/>
    <dbReference type="OMA" id="NSIREYA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="204" mass="22675" checksum="31C02E5C527F17E9" modified="2009-03-03" version="1">MQTDFSAVVFDYFDVLVDWRPHRVVGAFYPPGVTDMFFDDHDPHGYEFCRARAAAGVPDGKILDDYTREHGPAVGWILRLLLQHRALGFYDMPVGMPTLLRELRAAGVRMVGLANCSETAVEQMQVKYPWLGLLDGTMVSARECIAKPDPALFERAIRAFHLDTAHTLFVENTAANAAAACELGLHAVRFESAEQIRALLLPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV98</accession>
    <name>B8DV98_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0096"/>
    <dbReference type="EnsemblBacteria" id="ACL28399">
        <property type="protein sequence ID" value="ACL28399"/>
        <property type="gene ID" value="BLA_0096"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0096"/>
    <dbReference type="HOGENOM" id="CLU_715088_0_0_11"/>
    <dbReference type="OMA" id="MANTIVH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="338" mass="34945" checksum="DD2ECAFAEA764327" modified="2009-03-03" version="1">MVCLGVGLNIVGLGRDTQAIPPAPVTEVEAPQLPVPLTDDAIKAAGLHEATPTVSVSQMTATALDNLSAVDGSSALDTVAISLSSDQREQIEQNLQAFADAGAQVSFAVADLGSGGVIAANGGVARYPASSIKAPYIVSLLQEGAVNLDETASGSTLSAQINADHIAGVLRYSDNDGYDALWNAHLNSAIIPWSEGLVENPERMRGFQYPDVSAVELAKMWVKTYGYLFADAEGEPNAGETASAPAREWLASSMHHSLNSSIDAAHGGEENPDGTVVLSKAGWINGEGDYYALNDAGIVLPSGESGNEPGYAIAIMSNACGRNDLLADLAGTLHNILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVA8</accession>
    <name>B8DVA8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative outer membrane protein probably involved in nutrient binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218403.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0106"/>
    <dbReference type="EnsemblBacteria" id="ACL28409">
        <property type="protein sequence ID" value="ACL28409"/>
        <property type="gene ID" value="BLA_0106"/>
    </dbReference>
    <dbReference type="GeneID" id="66532481"/>
    <dbReference type="KEGG" id="bla:BLA_0106"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.110"/>
    <dbReference type="HOGENOM" id="CLU_072993_2_0_11"/>
    <dbReference type="OMA" id="NVTFTPC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="52"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="147" mass="15972" checksum="59074E8264A172BF" modified="2009-03-03" version="1">MNNYPIPVGVPTAYAQSLMFPVGEPNDAYAQYFTGRSWLAPVSGEQVSMANVTFEPGCINHWHIHHATKGGGQMLICVGGRGYAQIEGQEPIAMTPGTVVHIPANTKHWHGAAPGSWFSHIAIDVPGEGKSNDWLEPVDEAFYRSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVB6</accession>
    <name>B8DVB6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable flavodoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0114"/>
    <dbReference type="EnsemblBacteria" id="ACL28417">
        <property type="protein sequence ID" value="ACL28417"/>
        <property type="gene ID" value="BLA_0114"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0114"/>
    <dbReference type="HOGENOM" id="CLU_068890_0_0_11"/>
    <dbReference type="OMA" id="CPRPVNT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001226">
        <property type="entry name" value="Flavodoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12682">
        <property type="entry name" value="Flavodoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00201">
        <property type="entry name" value="FLAVODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="134" mass="14709" checksum="1BC66AB95DDAE860" modified="2009-03-03" version="1">MSKQLVVYISATGTTRRVAQNLAKAIDADLAEIVPVPPFTAQDIDWTDPTSRASRQHADRAMRPPISASPSADGYDEIFVGYPLWWDTAPREVRTWLESHDFTGKTITTFATSSSAHAAHSASNCTIRHRTPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVC1</accession>
    <name>B8DVC1_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="13">FBP aldolase</shortName>
            <ecNumber evidence="5 13">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">fbaA</name>
        <name evidence="14" type="ordered locus">BLA_0119</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="5 13"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218417.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0119"/>
    <dbReference type="EnsemblBacteria" id="ACL28422">
        <property type="protein sequence ID" value="ACL28422"/>
        <property type="gene ID" value="BLA_0119"/>
    </dbReference>
    <dbReference type="GeneID" id="66532494"/>
    <dbReference type="KEGG" id="bla:BLA_0119"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.124"/>
    <dbReference type="HOGENOM" id="CLU_036923_1_0_11"/>
    <dbReference type="OMA" id="PRTWGKL"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="PTHR30559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01520">
        <property type="entry name" value="FruBisAldo_II_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 13 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="11">
        <location>
            <begin position="264"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="11">
        <location>
            <begin position="285"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACL28422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="354" mass="38259" checksum="B2824DF693915DA5" modified="2009-03-03" version="1">MSIATPEQYAHMLDAARAGGYAYPAINVTSSQTLNAALQGLADAESDGIIQVSVGGAAYFSGQRVNNRVTGSLAFAAFAHEVAKQYPNITVALHTDHCAKQYLDEWVNPLLDIEIDEVKHGREPMFQSHMWDGSTVPLKENLDIAEKLLEKSRLAHTVLEIEIGAVGGEEDGHSAEINEKLYSSVADGMAVADRLGLGERGKYMAAFTFGNVHGAYKPGVVKLRPELLHEIQQGVWNAAKSGELNAVLNSDMPDGKPFELVFHGGSGSTAQEIAEAVSYGVIKMNIDTDTQYAFTRAVAGHMFRDYDGVLKIDGEVGNKKQYDPRSWGREAEDSMAARVVEACEELGSAGRALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVD7</accession>
    <name>B8DVD7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218440.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0135"/>
    <dbReference type="EnsemblBacteria" id="ACL28438">
        <property type="protein sequence ID" value="ACL28438"/>
        <property type="gene ID" value="BLA_0135"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0135"/>
    <dbReference type="HOGENOM" id="CLU_101288_3_0_11"/>
    <dbReference type="OMA" id="CAEFIEY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="90"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="170" mass="19060" checksum="2D4A2DC593CB58AE" modified="2009-03-03" version="1">MGMTAMPFTRPERAQCPVDFTGFDCGEQQINDWLKHHANASNKNGSAALYLSYDHETNELAGVYTLSSTTVARDETYAPWMRRNSPILVPAALLGQLAVANHFQHRGLAKALIRDAVDRTLQLSLTIGIRALVVDPLNSNLTMFYDSLGFEGFNGETRMYFRMPNYPRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVE9</accession>
    <name>B8DVE9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-acylglucosamine 2-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218455.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0147"/>
    <dbReference type="EnsemblBacteria" id="ACL28450">
        <property type="protein sequence ID" value="ACL28450"/>
        <property type="gene ID" value="BLA_0147"/>
    </dbReference>
    <dbReference type="GeneID" id="66532521"/>
    <dbReference type="KEGG" id="bla:BLA_0147"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.155"/>
    <dbReference type="HOGENOM" id="CLU_042253_0_0_11"/>
    <dbReference type="OMA" id="DWRLPEH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="421" mass="47467" checksum="FA2239D3EA402AAA" modified="2009-03-03" version="1">MANTDPKYQIGTPENKKFLDISRDNLIAFGRRFPAVDGSSYWLGDDGTPWKDRNRATWITCRMTHVYSLATLLGVDGAAELVDDGIRGLRGVLHDEEHDGWYAEITPDICHMPTKQAYAHAFVLLAASSALLAGRPGAKELLEQAENVYLTKFWDDKIGLSVDTWDTDFAELDTYRGLNANMHSVEACLAVADVTGDESWRTRAGRIIEHVLKWAEENNWRIPEHFNSDWEPELEFNADKPDDQFKPYGATPGHGIEWARLITQYALSVYGKDGVLNGDGKKYLDAAEHLFNRAVEDAWNADGAPGIVYTTDWDGKPVVHDRMHWTLAEGVNTAATLYHVTGKKEYADWYATFLEYIDTYLMDHKNGSWFHQLNRENEVIDTVWPGKSDLYHATQAMMIPLRDPALSIAPATKKGVEEGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVG5</accession>
    <name>B8DVG5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Branched-chain amino acid transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">livF</name>
        <name evidence="3" type="ordered locus">BLA_0164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218478.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0164"/>
    <dbReference type="EnsemblBacteria" id="ACL28466">
        <property type="protein sequence ID" value="ACL28466"/>
        <property type="gene ID" value="BLA_0164"/>
    </dbReference>
    <dbReference type="GeneID" id="66532539"/>
    <dbReference type="KEGG" id="bla:BLA_0164"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.173"/>
    <dbReference type="HOGENOM" id="CLU_027128_5_0_11"/>
    <dbReference type="OMA" id="PNQFAAD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870820" evidence="1">
        <location>
            <begin position="33"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="46"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="419" mass="43898" checksum="C7DD0333CBE3D088" modified="2009-03-03" version="1">MNKPNRKTWRTTATAMAATAVLTLSGCGTGTADSSANAAEDTFVAGGLFPLTGTAAYLGPSNVSTMKLAEQDIDEAGGVLGNKISTITADTSDAEHADQNATAVQSVLSKNPSVVIGPPLSSVVKNTYKQVTTSKIPMISPGATSTAFSGLDDYFFRTIPPDTVQGVVMGDLIAQDGIKNLAIAVFNDEYGISLRAEVLKTLKEGGVNVVYGETETFDPAENNFSSIATNIKATNPDAVLVIAADQTIPLVKELAAKGIDTHKLYMPDSNMVDHSKDFTSGLLKGSKGTIPGAHPTSEFQNALKTIAPDTTIYTYNTETYDAMVLAALAAEKGGAADSETVQKNLMAVSGTTKGEKCESYEDCVALMKSGKEIQYVGKTSIGVFNNAHDPSTASIGIYEYDDSNVPVFLDSQEGAVPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVI5</accession>
    <name>B8DVI5_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit GatD</fullName>
            <ecNumber evidence="1">6.3.5.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase glutaminase subunit</fullName>
            <ecNumber evidence="1">3.5.1.2</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatD</name>
        <name evidence="3" type="ordered locus">BLA_0184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57928"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with MurT.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CobB/CobQ family. GatD subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.13" evidence="1"/>
    <dbReference type="EC" id="3.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218501.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0184"/>
    <dbReference type="EnsemblBacteria" id="ACL28486">
        <property type="protein sequence ID" value="ACL28486"/>
        <property type="gene ID" value="BLA_0184"/>
    </dbReference>
    <dbReference type="GeneID" id="66532560"/>
    <dbReference type="KEGG" id="bla:BLA_0184"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.194"/>
    <dbReference type="HOGENOM" id="CLU_064047_0_0_11"/>
    <dbReference type="OMA" id="GTYMHGP"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140282">
        <property type="term" value="F:carbon-nitrogen ligase activity on lipid II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02213">
        <property type="entry name" value="Lipid_II_synth_GatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043702">
        <property type="entry name" value="Lipid_II_synth_GatD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase_3" evidence="2">
        <location>
            <begin position="7"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="249" mass="27624" checksum="9F89685659ED9DB2" modified="2009-03-03" version="1">MSKAIDVVSLYPKDMNIYGDSGNVLAVERRLALYGYEPHVHAVNQNDPWPEHADIILGGGGQDTGQKKIIEDLFRRADRLRDLAEHGVPMLMICGLYQLFGEYFETIDGTKLEGISIIRAYTVGRDVRMIGNLVEHSAQFGDVLGYENHSGQTFLREGVQPLGTVDGDGTGNNGEDHTEGARVHNVIGTYMHGSLLPKNPKITDFMIRTAVERRYGAFDPEQTDAQRAELARIDEYAAHAREAAATRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVL3</accession>
    <name>B8DVL3_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">tmk</name>
        <name evidence="5" type="ordered locus">BLA_0212</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219308.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0212"/>
    <dbReference type="EnsemblBacteria" id="ACL28514">
        <property type="protein sequence ID" value="ACL28514"/>
        <property type="gene ID" value="BLA_0212"/>
    </dbReference>
    <dbReference type="GeneID" id="66532586"/>
    <dbReference type="KEGG" id="bla:BLA_0212"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.225"/>
    <dbReference type="HOGENOM" id="CLU_049131_0_0_11"/>
    <dbReference type="OMA" id="VMTREPG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="4">
        <location>
            <begin position="9"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="206" mass="22516" checksum="68C01357ABCE68A8" modified="2009-03-03" version="1">MGAGLFISFEGVDGAGKTTQVNLLADYLRALGREVVVTREPGGTALGTQIRAMLLTTNPDEEISPRTEALLFAADRAQHVSEVIRPALERGAVVITDRYLDSSLAYQSGGRELTADDIRTLSMWATNNLLPARTYLLDIDPRASHTRLEHAEDRMESAGDDFQQRTRTAFLELAAVQPQRFCVIDAQQSVGEIAALICDDVANLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVL5</accession>
    <name>B8DVL5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0098 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0214"/>
    <dbReference type="EnsemblBacteria" id="ACL28516">
        <property type="protein sequence ID" value="ACL28516"/>
        <property type="gene ID" value="BLA_0214"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0214"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.227"/>
    <dbReference type="HOGENOM" id="CLU_083918_4_2_11"/>
    <dbReference type="OMA" id="FNDSHAL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00481">
        <property type="entry name" value="TIGR00481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="184" mass="20369" checksum="89CB4992C3408CA0" modified="2009-03-03" version="1">MLVSADFNTIPEQYAKNAPDDARVDGVPCVSFPFYIDHLNPAAKYLHWEFSDPDSIPVCGFEWIHWTMANLPVAALMFDPSDAHALQIPPDFSRRVTAMIPEAVQGRNSQASPLYGQDQRNLQLVAHYTGPQPPDKDHGYVLQIWGTTSPIAGLEQGFWLNEMLHGLEHSQVVDGGGITLIGKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVM0</accession>
    <name>B8DVM0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MifH/DopD protein family-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219301.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0219"/>
    <dbReference type="EnsemblBacteria" id="ACL28521">
        <property type="protein sequence ID" value="ACL28521"/>
        <property type="gene ID" value="BLA_0219"/>
    </dbReference>
    <dbReference type="GeneID" id="66532593"/>
    <dbReference type="KEGG" id="bla:BLA_0219"/>
    <dbReference type="HOGENOM" id="CLU_129906_0_0_11"/>
    <dbReference type="OMA" id="KSENWLM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="PTHR11954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="SSF55331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="115" mass="12533" checksum="2FDD5284B18ABCD5" modified="2009-03-03" version="1">MPVIHTHVSVPTTAEQRDALKTAFGQAIPAVPGKSEGWLMCLFESDVPMYFGGTNDAPAAYVEVNVFGSSVPKSAWQKLTPAIMDALQDTLQIPADRTYIRYTATPDWGWNGGNF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVP8</accession>
    <name>RL28_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmB</name>
        <name type="ordered locus">BLA_0247</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268348.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DVP8"/>
    <dbReference type="SMR" id="B8DVP8"/>
    <dbReference type="STRING" id="442563.BLA_0247"/>
    <dbReference type="EnsemblBacteria" id="ACL28549">
        <property type="protein sequence ID" value="ACL28549"/>
        <property type="gene ID" value="BLA_0247"/>
    </dbReference>
    <dbReference type="GeneID" id="66532623"/>
    <dbReference type="KEGG" id="bla:BLA_0247"/>
    <dbReference type="HOGENOM" id="CLU_064548_7_0_11"/>
    <dbReference type="OMA" id="RINVCTS"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000195904" description="50S ribosomal protein L28">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <sequence length="65" mass="7205" checksum="2DAC430CBCC69D76" modified="2009-03-03" version="1">MAARCAVCGKGPQTGYTVSHSHIRNKRRFLPNLQPVRTTVDGQNVRLRVCTKCLKAGKVQRVKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVQ1</accession>
    <name>B8DVQ1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28552">
        <property type="protein sequence ID" value="ACL28552"/>
        <property type="gene ID" value="BLA_0250"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0250"/>
    <dbReference type="HOGENOM" id="CLU_2462861_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="88" mass="9469" checksum="E524992702348289" modified="2009-03-03" version="1">MGSIGLPSWFGMVARAGSGTRACFALLVALWRSGCLVVVARSGMHSLMLATSWDELLLDADPMLDHHAQFAGAVLDFSRGNERFLTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVR6</accession>
    <name>B8DVR6_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease 3</fullName>
            <ecNumber evidence="6">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ribonuclease III</fullName>
            <shortName evidence="6">RNase III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">rnc</name>
        <name evidence="11" type="ordered locus">BLA_0265</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonuclease III family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="6"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268379.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0265"/>
    <dbReference type="EnsemblBacteria" id="ACL28567">
        <property type="protein sequence ID" value="ACL28567"/>
        <property type="gene ID" value="BLA_0265"/>
    </dbReference>
    <dbReference type="GeneID" id="66532640"/>
    <dbReference type="KEGG" id="bla:BLA_0265"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.282"/>
    <dbReference type="HOGENOM" id="CLU_000907_1_2_11"/>
    <dbReference type="OMA" id="LTHKSCK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02191">
        <property type="entry name" value="RNaseIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="RNase III" evidence="10">
        <location>
            <begin position="11"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="9">
        <location>
            <begin position="169"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL28567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="258" mass="28413" checksum="A1921E26DB79C602" modified="2009-03-03" version="1">MSVRVSTQEIGESAMQELFTALGTTLETDLLVEALTHRSFSHEHEGVKNYERLEFLGDAVLEFVVTETLFKQYPDKSEGQLAKIRAKAVSEESLSAIARDRLHVGPYILLGHGESEQGGAEKSSILCDIVESLIGATFVQYGVDKAREVVHHLVDDTLAEVATEGPALDWKTSLTVKAHEMGLPEPRYQMSVGGPEYALEFTAFAMLGDSKEVLGVGNGSSKRKAQLAAAEQAWHVLDEREHAPKPERKRERRPLTDA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVS6</accession>
    <name>IXTPA_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="1">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="1">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">BLA_0275</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268398.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DVS6"/>
    <dbReference type="SMR" id="B8DVS6"/>
    <dbReference type="STRING" id="442563.BLA_0275"/>
    <dbReference type="EnsemblBacteria" id="ACL28577">
        <property type="protein sequence ID" value="ACL28577"/>
        <property type="gene ID" value="BLA_0275"/>
    </dbReference>
    <dbReference type="GeneID" id="66532650"/>
    <dbReference type="KEGG" id="bla:BLA_0275"/>
    <dbReference type="HOGENOM" id="CLU_082080_0_1_11"/>
    <dbReference type="OMA" id="DCFADDT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000184577" description="dITP/XTP pyrophosphatase">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="182"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="219"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <sequence length="239" mass="25227" checksum="5ACC62C018BAC2A9" modified="2009-03-03" version="1">MNIVVATHNEGKLVEIRDILAEEFGDGAHDIELVSAGSLGLPDPVETGITFEANALLKARFVARLTGLPAIADDSGLIVDVMGNAPGILSARWAGEHGNDAANIDLLLAQIEDIPDDDRTARFRCAAALVVPIAAEEDVADFEADPSDGMDDGDGLVDARETVVLGEMPGTIVRHPHGSNGFGYDPIFMPDEQPAGAEESGELLTSAEMTPEQKNAISHRGKALRALMPAIRELVETGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVT2</accession>
    <name>B8DVT2_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Signal peptidase I</fullName>
            <ecNumber evidence="3 5">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lepB</name>
        <name evidence="8" type="ordered locus">BLA_0281</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase S26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3 5"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268409.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0281"/>
    <dbReference type="MEROPS" id="S26.025"/>
    <dbReference type="EnsemblBacteria" id="ACL28583">
        <property type="protein sequence ID" value="ACL28583"/>
        <property type="gene ID" value="BLA_0281"/>
    </dbReference>
    <dbReference type="GeneID" id="66532658"/>
    <dbReference type="KEGG" id="bla:BLA_0281"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.299"/>
    <dbReference type="HOGENOM" id="CLU_028723_0_1_11"/>
    <dbReference type="OMA" id="ACDAYIK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="7">
        <location>
            <begin position="46"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="241" mass="26359" checksum="B7EE304B23AD17C3" modified="2009-03-03" version="1">MDSSNEPMPQSPAPMETHGNRDAGAGNLDSAGTEQQLASTRGTAIRDFFLWCAIPVAIVVLLRIFVFGMYVIPSRSMENTIMPGDRVITTKLSPRPVALKRGDIVVFKDPSNWLASEETTYHSDYLIKRLIGMPGDTVECEGAGQPVKINGVAIDESAYVKPGDQPSTFPFKVTVSEGHVFVMGDNRSNSADSRFHLNDAQHGQVPIRDIAGVAFARYWPLNRISWLSNYSDVFANVPDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVU6</accession>
    <name>B8DVU6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">50S ribosomal protein L11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplK</name>
        <name evidence="5" type="ordered locus">BLA_0295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0295"/>
    <dbReference type="EnsemblBacteria" id="ACL28597">
        <property type="protein sequence ID" value="ACL28597"/>
        <property type="gene ID" value="BLA_0295"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0295"/>
    <dbReference type="HOGENOM" id="CLU_074237_3_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L11" evidence="4">
        <location>
            <begin position="22"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="92" mass="9723" checksum="43703DD3209F7E42" modified="2009-03-03" version="1">MGQVIPVEITVYEDRSFDFVLKTPPASDLLKKAAGVAKGASNPLTDKVGSVTKAQVKEIAETKMADLSARDIDAAMKIIEGSARSMGITVND</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVV7</accession>
    <name>RS15_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsO</name>
        <name type="ordered locus">BLA_0306</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268464.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DVV7"/>
    <dbReference type="SMR" id="B8DVV7"/>
    <dbReference type="STRING" id="442563.BLA_0306"/>
    <dbReference type="EnsemblBacteria" id="ACL28608">
        <property type="protein sequence ID" value="ACL28608"/>
        <property type="gene ID" value="BLA_0306"/>
    </dbReference>
    <dbReference type="GeneID" id="66532685"/>
    <dbReference type="KEGG" id="bla:BLA_0306"/>
    <dbReference type="HOGENOM" id="CLU_148518_0_0_11"/>
    <dbReference type="OMA" id="FKTHVKD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000166401" description="30S ribosomal protein S15">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <sequence length="89" mass="10457" checksum="CCFC0A3EA07A36AE" modified="2009-03-03" version="1">MALTAEEKQDIIAKYATHEGDTGSPEVQIALLTKRIADLTEHLKFHKHDHHSRRGLLLMVGDRRRLLDYLKKVDIERYRSLIERLGLRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVY5</accession>
    <name>RL7_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L7/L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplL</name>
        <name type="ordered locus">BLA_0334</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268512.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DVY5"/>
    <dbReference type="SMR" id="B8DVY5"/>
    <dbReference type="STRING" id="442563.BLA_0334"/>
    <dbReference type="EnsemblBacteria" id="ACL28636">
        <property type="protein sequence ID" value="ACL28636"/>
        <property type="gene ID" value="BLA_0334"/>
    </dbReference>
    <dbReference type="GeneID" id="66532713"/>
    <dbReference type="KEGG" id="bla:BLA_0334"/>
    <dbReference type="HOGENOM" id="CLU_086499_3_0_11"/>
    <dbReference type="OMA" id="LEDKWGV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000195771" description="50S ribosomal protein L7/L12">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="126" mass="13227" checksum="60E7DB16EDBEC67B" modified="2009-03-03" version="1">MAKFTQDELLEAFGEMTLVELSDFVKAFEEKFDVEAAAPVAAVAAAAPGAAPAEEEKDEFTVVLSAVGDKKIQVIKAVRAITNLGLAEAKALVDGAPKPVLENAKKEDAEKAKAQLEEAGATVELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVZ2</accession>
    <name>B8DVZ2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible acetytransferase</fullName>
            <ecNumber evidence="2">2.3.1.128</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.128" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268530.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0341"/>
    <dbReference type="EnsemblBacteria" id="ACL28643">
        <property type="protein sequence ID" value="ACL28643"/>
        <property type="gene ID" value="BLA_0341"/>
    </dbReference>
    <dbReference type="GeneID" id="66532720"/>
    <dbReference type="KEGG" id="bla:BLA_0341"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.366"/>
    <dbReference type="HOGENOM" id="CLU_013985_40_0_11"/>
    <dbReference type="OMA" id="AACIPDN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="227" mass="25823" checksum="7AB09169072B57F0" modified="2009-03-03" version="1">MSVFQALHDVMKRRRNSAFTAPLTLKSPAGSPDLTLRTMDAADQEEWGRLRSVNERWLAPWESSDPHGTEPLTFKSWVNRQREEEREGTSIIFLMEHEGEIVGQISLGAIYPGPMRTGIIGYWIDEDHAGRGLTPLAVAMLADWALLDPTGPQLHRLEIDIVPENERSRRVVQKVGAKYEGVRRQYMYVHGEWRDHESYSLLDTDVPQGFVHRLLGDTPGESLHNLS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW24</accession>
    <name>RL24_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplX</name>
        <name type="ordered locus">BLA_0373</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1">One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268591.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DW24"/>
    <dbReference type="SMR" id="B8DW24"/>
    <dbReference type="STRING" id="442563.BLA_0373"/>
    <dbReference type="EnsemblBacteria" id="ACL28675">
        <property type="protein sequence ID" value="ACL28675"/>
        <property type="gene ID" value="BLA_0373"/>
    </dbReference>
    <dbReference type="GeneID" id="66532756"/>
    <dbReference type="KEGG" id="bla:BLA_0373"/>
    <dbReference type="HOGENOM" id="CLU_093315_2_0_11"/>
    <dbReference type="OMA" id="HVKPTQE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_L24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="PTHR12903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000165927" description="50S ribosomal protein L24">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <sequence length="111" mass="12198" checksum="D1701BCF80DF7262" modified="2009-03-03" version="1">MVAKIKSGDLVKVIRGKDRGKEGTVKRVLKDDRLIVEGVQIVKKHVRATQQGQQAGIVSVEAPIHRSNVMVIDPETKQPTRVGVVIKEEARDGKVKTVRVRVAKKSGKELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW42</accession>
    <name>B8DW42_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription termination/antitermination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">nusA</name>
        <name evidence="10" type="ordered locus">BLA_0391</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Participates in both transcription termination and antitermination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268625.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0391"/>
    <dbReference type="EnsemblBacteria" id="ACL28693">
        <property type="protein sequence ID" value="ACL28693"/>
        <property type="gene ID" value="BLA_0391"/>
    </dbReference>
    <dbReference type="GeneID" id="66532775"/>
    <dbReference type="KEGG" id="bla:BLA_0391"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.419"/>
    <dbReference type="HOGENOM" id="CLU_029242_2_2_11"/>
    <dbReference type="OMA" id="MDIDMSA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_B">
        <property type="entry name" value="NusA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010213">
        <property type="entry name" value="Tscrpt_termination_fac_NusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="SSF69705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01953">
        <property type="entry name" value="NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 7" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="S1 motif" evidence="9">
        <location>
            <begin position="122"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL28693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="358" mass="38612" checksum="F53E349D2C5586B0" modified="2009-03-03" version="1">MKLDLNGIHALAQEQGIDAETVDAALSEALRLAYLKMPHAAKYARVELDPRAGSFTIWARDEIPQEPTEDNPHPAPELGEEYDDTPHDFGRLAASTARQVIQQLFRKAEDDRVFGAFSGQRGKLITGVVQQDVKDPANVHVAVGDVEALLPRREQVPGERYRHGERIRVYVTTVARGLKGPEIIVSRSHPELVRRLFEREVPELASGAVSIMAIAREAGARTKIAVRANTPGINPKGALIGPGGSRVRAVMENLGSEKIDIIDWSANPAEFIAAALSPAVVSDVQVISEKNQTAIAFINDEQLSLAIGKEGQNARLAAKLTGWKIGIESNSAHAAKLREQAAKAADGTQSGNAEESAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW44</accession>
    <name>B8DW44_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-binding factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">rbfA</name>
        <name evidence="3" type="ordered locus">BLA_0393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RbfA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268628.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0393"/>
    <dbReference type="EnsemblBacteria" id="ACL28695">
        <property type="protein sequence ID" value="ACL28695"/>
        <property type="gene ID" value="BLA_0393"/>
    </dbReference>
    <dbReference type="GeneID" id="66532777"/>
    <dbReference type="KEGG" id="bla:BLA_0393"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.421"/>
    <dbReference type="HOGENOM" id="CLU_089475_0_1_11"/>
    <dbReference type="OMA" id="GDLQHCK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00003">
        <property type="entry name" value="RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020053">
        <property type="entry name" value="Ribosome-bd_factorA_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33515">
        <property type="entry name" value="PTHR33515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="SSF89919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00082">
        <property type="entry name" value="rbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01319">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="217" mass="24538" checksum="CB6373EB2C566D45" modified="2009-03-03" version="1">MQGTNSRAARIAALIQRVIASNMESTLHDKRLKNVTITDVKVTNDLQLAKIYWTTLSRDGHEEGERKRAKEALNQAKGRLRTMVGAKAGLRLTPQLQFIFDEVPGEAHEIEDILSLARKRDEELARMRANAAYAGDADPYRHDDETEEAVEEELDEQEHENKDEYTEYPGDVVEVEEFEDFDNSGDDLEHSDDDPVDPVATDPASTIDTVDDHDEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW46</accession>
    <name>B8DW46_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Riboflavin kinase</fullName>
            <ecNumber evidence="12">2.7.1.26</ecNumber>
            <ecNumber evidence="12">2.7.7.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ribF</name>
        <name evidence="12" type="ordered locus">BLA_0395</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + riboflavin = ADP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RibF family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="12"/>
    <dbReference type="EC" id="2.7.7.2" evidence="12"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268630.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0395"/>
    <dbReference type="EnsemblBacteria" id="ACL28697">
        <property type="protein sequence ID" value="ACL28697"/>
        <property type="gene ID" value="BLA_0395"/>
    </dbReference>
    <dbReference type="GeneID" id="66532779"/>
    <dbReference type="KEGG" id="bla:BLA_0395"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.423"/>
    <dbReference type="HOGENOM" id="CLU_048437_0_0_11"/>
    <dbReference type="OMA" id="HRGHQAI"/>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02064">
        <property type="entry name" value="FAD_synthetase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015864">
        <property type="entry name" value="FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="PTHR22749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06574">
        <property type="entry name" value="FAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavokinase" evidence="11">
        <location>
            <begin position="244"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACL28697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="428" mass="47021" checksum="914EC42C8EA75908" modified="2009-03-03" version="1">MDIFRLTPAADGNVAWPTLSTSKKSVVTVGAFDGLHVGHHAVIEETVRQARKLDAYSVVIMFDPRPAFVHAYAKAHAGKDVPAGVHDPEAITGVDARLRMLSRMHVDYVLIVRYTIAFSEKSFRFFLGQLVGKLGMRMLVLGEDARMGANLEGDIKKIRTLAEATGVFELEVVTNQGGTVRVPERFTPTAPNEPGEPGDPLEGLGKAERRAWSKKHNAREVRNQSSTNVRYLLSQGRVQAANEILGHAHAVEGVVEHGEERGRTIGFPTANIAEPMEGYLPVDGVYAGWLVDLGPADEYERDQQQLSGKAADGEAVEAASVTVSDTPVVSHRFSSSRVDSRLAAQSPFRWPAAISIGTKPTYSESTGLNERVLEAYALTDEWLDLYGHRVRVEFERFLRPQIKFGSTDELVAELKHNVEETKELLGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW51</accession>
    <name>B8DW51_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease H</fullName>
            <ecNumber evidence="5">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rnh</name>
        <name evidence="8" type="ordered locus">BLA_0400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="5"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268642.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0400"/>
    <dbReference type="EnsemblBacteria" id="ACL28702">
        <property type="protein sequence ID" value="ACL28702"/>
        <property type="gene ID" value="BLA_0400"/>
    </dbReference>
    <dbReference type="GeneID" id="66532783"/>
    <dbReference type="KEGG" id="bla:BLA_0400"/>
    <dbReference type="HOGENOM" id="CLU_049854_0_0_11"/>
    <dbReference type="OMA" id="GSVKFVW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09278">
        <property type="entry name" value="RNase_HI_prokaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022892">
        <property type="entry name" value="RNaseHI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="7">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="203"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="329" mass="34976" checksum="90BE2C99036A6D4A" modified="2009-03-03" version="1">MTITVSTDGSALRNPNGPMGWAWADHTDGARDEHAHAGDCAAGGATNGTNQIGELCAVLEALRAHPGSEPLVIESDSQYAINCSSKWVFGWKKNGWKNSKQEPVKNAPIIKAIDAEISKRAGKVSFRWVKGHAGNAGNEKVDDLARGFAGDCESGAQEGYLPKEGWQALLESPYARDVKVPADAQLLLDGEMDEREYTRLHAAEVDDLEHGEPNLTELGDVRTPADSAETDAPADTAAHAAESAADGTDTPAGEPTATAGMQLAPTGLAASGRVTLSPPPNSSPYYDGSPRRIHGYIEVDALVQGDGTVDLENARFLMHRRENGQETRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW60</accession>
    <name>B8DW60_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phage shock protein C, PspC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pspC</name>
        <name evidence="9" type="ordered locus">BLA_0409</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619710.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0409"/>
    <dbReference type="EnsemblBacteria" id="ACL28711">
        <property type="protein sequence ID" value="ACL28711"/>
        <property type="gene ID" value="BLA_0409"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0409"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.437"/>
    <dbReference type="HOGENOM" id="CLU_024911_0_0_11"/>
    <dbReference type="OMA" id="NANPYQP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="8">
        <location>
            <begin position="92"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="213"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL28711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="707" mass="74855" checksum="B017E0B8C49C5ECE" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW62</accession>
    <name>B8DW62_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cystathionine beta-lyase</fullName>
            <ecNumber evidence="4">4.4.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">metC</name>
        <name evidence="4" type="ordered locus">BLA_0411</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268678.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0411"/>
    <dbReference type="EnsemblBacteria" id="ACL28713">
        <property type="protein sequence ID" value="ACL28713"/>
        <property type="gene ID" value="BLA_0411"/>
    </dbReference>
    <dbReference type="GeneID" id="66532795"/>
    <dbReference type="KEGG" id="bla:BLA_0411"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.439"/>
    <dbReference type="HOGENOM" id="CLU_018986_2_0_11"/>
    <dbReference type="OMA" id="THGGIIV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004121">
        <property type="term" value="F:cystathionine beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="399" mass="43144" checksum="7006F480D8371BB9" modified="2009-03-03" version="1">MTQLNTKLVHGVPVTDNATGAVNPPIYNSSTYAFESVGSMPRWDYARSGNPTRDFLERQIAQLEHGVRGFAFASGLAAIHAVLSIFAPGERIVVGSNIYGGTYSLFNEHFNRWGLVSYPVDTQDLRELEHAIGGHGEQAPAKAVYFETLTNPLLQVNDVHAIAEIAHKYGAIVIVDNTFVTPYLQQPLDLGADIVIHSATKYLAGHSDVVAGLVAVANDILAARVYYSQNRLGGVLAPAECDAVRRGIQTLALRLERQQENALAVARHLDEHAAVARVHYPGLHGEAVASKGLRGAGGVLSFEVREGVNPADVLNNLQTFRLAVSLGAVESLAEYPARMTHFELPRSERLKVGVTDELIRLAVGIEDVRDLIEDLDQALAIATGHAQAPQSLELASLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW95</accession>
    <name>B8DW95_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28746">
        <property type="protein sequence ID" value="ACL28746"/>
        <property type="gene ID" value="BLA_0445"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0445"/>
    <dbReference type="HOGENOM" id="CLU_034837_0_0_11"/>
    <dbReference type="OMA" id="HCETEFN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019219">
        <property type="entry name" value="DUF2130"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09903">
        <property type="entry name" value="DUF2130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005850">
        <property type="entry name" value="UCP005850"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="495" mass="57452" checksum="790F259744C87C9D" modified="2009-03-03" version="1">MASHEIKCPHCGESFTIDEAGYADIVQQVRGQEFDRELESRLKLAEDDKAKAVELARQKANSELQQAKASKDAEISELKAQLAAFEDRQKLAVSEAVGDVEKERDELRHEVERLKSDAESERELAKANLEAEKAKAAAEKDVRIQQLQSQLDNVQTSKQLEIAEQVGKVERECDRLRGELSTAKMQQELELKSVREQYEVQLRDREDEIERLRDFKTRLSTKMVGESLERHCQDEFNKVRMGSFPNAYFEKDNDARTGSKGDFIFRDYDGPEDDEGRTEFISIMFEMKNENETTATKHRNEDFFKELDKDRREKGCEYAVLVSMLEEDSDLYNQGIVDVSYRYPKMYVIRPQYFIQMITLLRNAARGTLEYRRELAEMRAQNIDITNFEDKLNEFKSGFERNYELASKKFQTVIDEIDKSIDHLQKTKKALLGSEDNLRIANKKVQEVTVRRLTYKNPTMQEKFKQARAVRDEEKAIGKVPEVGIELAEDTGVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWB0</accession>
    <name>B8DWB0_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Beta-galactosidase</fullName>
            <shortName evidence="5">Beta-gal</shortName>
            <ecNumber evidence="3 5">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BLA_0462</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 42 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 5"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268781.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0462"/>
    <dbReference type="CAZy" id="GH42">
        <property type="family name" value="Glycoside Hydrolase Family 42"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28761">
        <property type="protein sequence ID" value="ACL28761"/>
        <property type="gene ID" value="BLA_0462"/>
    </dbReference>
    <dbReference type="GeneID" id="66532844"/>
    <dbReference type="KEGG" id="bla:BLA_0462"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.491"/>
    <dbReference type="HOGENOM" id="CLU_012430_1_1_11"/>
    <dbReference type="OMA" id="SRRHYCF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013739">
        <property type="entry name" value="Beta_galactosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013738">
        <property type="entry name" value="Beta_galactosidase_Trimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003476">
        <property type="entry name" value="Glyco_hydro_42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013529">
        <property type="entry name" value="Glyco_hydro_42_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36447">
        <property type="entry name" value="PTHR36447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02449">
        <property type="entry name" value="Glyco_hydro_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08533">
        <property type="entry name" value="Glyco_hydro_42C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08532">
        <property type="entry name" value="Glyco_hydro_42M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001084">
        <property type="entry name" value="B-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_42" evidence="8">
        <location>
            <begin position="28"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_42M" evidence="9">
        <location>
            <begin position="415"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_42C" evidence="10">
        <location>
            <begin position="639"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL28761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="695" mass="78241" checksum="F643374204C7FA30" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWB2</accession>
    <name>B8DWB2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable permease of ABC transporter system for sugars</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_0464</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269047.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0464"/>
    <dbReference type="EnsemblBacteria" id="ACL28763">
        <property type="protein sequence ID" value="ACL28763"/>
        <property type="gene ID" value="BLA_0464"/>
    </dbReference>
    <dbReference type="GeneID" id="66532846"/>
    <dbReference type="KEGG" id="bla:BLA_0464"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.493"/>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_11"/>
    <dbReference type="OMA" id="VSFGMIV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="98"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL28763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="322" mass="35428" checksum="8394E7A1B1E5D693" modified="2009-03-03" version="1">MTSTTKSPGTAGTPDAAAIAANAVTTGGSARVNKHHADWRGWKFLWPFALVFVFVFIIPILYAIYISFFQTKMIGGTQFVGFDNYIKLFHDPHFWSSVGRVTIFTVVQVPIMLCLAALMALALDSMKLHGTKFFRISTFLPYAVPAVVSTLIWAFMYGAKYGLVGSLNAWFGTHIDVLAPSVLLAAIGNIVTWEFTGYNMLIFYSSLSTIPHSLYEAASIDGASEWQIVKSIKLPELKGSLAITVIFSIIGSFQLFNEPSIMQNMVPGNTITTYYTPNMYAYNLSFSGNQSNYAAALAIVMAIITMAIAYAVQLRSMKDQMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWB9</accession>
    <name>B8DWB9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase</fullName>
            <ecNumber evidence="3">3.4.16.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dacB</name>
        <name evidence="3" type="ordered locus">BLA_0471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S13 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619733.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0471"/>
    <dbReference type="EnsemblBacteria" id="ACL28770">
        <property type="protein sequence ID" value="ACL28770"/>
        <property type="gene ID" value="BLA_0471"/>
    </dbReference>
    <dbReference type="GeneID" id="66532856"/>
    <dbReference type="KEGG" id="bla:BLA_0471"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.500"/>
    <dbReference type="HOGENOM" id="CLU_017692_0_2_11"/>
    <dbReference type="OMA" id="HSDNTLA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000667">
        <property type="entry name" value="Peptidase_S13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30023">
        <property type="entry name" value="PTHR30023"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02113">
        <property type="entry name" value="Peptidase_S13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00922">
        <property type="entry name" value="DADACBPTASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="481" mass="49773" checksum="D5D566928835D66A" modified="2009-03-03" version="1">MPRTARVAYGPVAHSPWPSPPSSPWGAAVPTCGPTSPTRHLESSPMPPCNRILPSRRGHLLTADAPFIANADTSRAIDAGEAAKLIDALRAKNGVGPDVSAIIMQADGTVVADHAADVAREPASTMKTLTSLAAASVLDMGDTLPTQTFLLQAEQGTDTVVIKGNGDMLLGAGDSDPDHVNGRAGLLTLAKNTAHALKQRGVTKVNLQYDDSLFGADRTPTGIEANNPDSLYYTPVSSMAIDGGRQWNGANPRNPDVFESYPALSQNTAADVTAIFRNLLGAQGITIVNAEPTQTTVSADRTPIAEVESAPLAMVMAFMLRHSDNTLAEEFGRLLALSTKQENSPAGATAAVRNELRTLGIDLTGLQMADCSGLTPGSRLTANTLAQVQARNLDVGGAVAAAEGLSIPGLVGTAANRLASTQAAGLTRVKTGSLQEVSSMTGNVSREQGGVAAFAVIVNNPEDFEATRTAINEFVAGLAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWC6</accession>
    <name>B8DWC6_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Energy-dependent translational throttle protein EttA</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Translational regulatory factor EttA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ettA</name>
        <name evidence="10" type="ordered locus">BLA_0478</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">Associates with ribosomes and polysomes.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619735.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0478"/>
    <dbReference type="EnsemblBacteria" id="ACL28777">
        <property type="protein sequence ID" value="ACL28777"/>
        <property type="gene ID" value="BLA_0478"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0478"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.507"/>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_11"/>
    <dbReference type="OMA" id="ISYKPQY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045900">
        <property type="term" value="P:negative regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00847">
        <property type="entry name" value="EttA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022374">
        <property type="entry name" value="EttA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43858">
        <property type="entry name" value="PTHR43858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03719">
        <property type="entry name" value="ABC_ABC_ChvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="6"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="324"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Arm" evidence="7">
        <location>
            <begin position="94"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <begin position="356"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL28777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="570" mass="62934" checksum="64833BF428053DD3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWD4</accession>
    <name>B8DWD4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="3">3.2.1.37</ecNumber>
            <ecNumber evidence="3">3.2.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="3"/>
    <dbReference type="EC" id="3.2.1.55" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219357.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0486"/>
    <dbReference type="CAZy" id="GH43">
        <property type="family name" value="Glycoside Hydrolase Family 43"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28785">
        <property type="protein sequence ID" value="ACL28785"/>
        <property type="gene ID" value="BLA_0486"/>
    </dbReference>
    <dbReference type="GeneID" id="66532872"/>
    <dbReference type="KEGG" id="bla:BLA_0486"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.516"/>
    <dbReference type="HOGENOM" id="CLU_486328_0_0_11"/>
    <dbReference type="OMA" id="TEWAGGF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="560" mass="61236" checksum="6AA0A64C7EE0AB63" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWD5</accession>
    <name>B8DWD5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LacI-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0487"/>
    <dbReference type="EnsemblBacteria" id="ACL28786">
        <property type="protein sequence ID" value="ACL28786"/>
        <property type="gene ID" value="BLA_0487"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0487"/>
    <dbReference type="HOGENOM" id="CLU_037628_15_1_11"/>
    <dbReference type="OMA" id="ANDVMAM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_3" evidence="1">
        <location>
            <begin position="12"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="176" mass="19045" checksum="0D8E379971F93B09" modified="2009-03-03" version="1">MADKWAGGVLATRHLLALGHTRIGIITGPEEMMCSRARLDGYTSALAEQGIELDPELVTEGDFTTEGGYAQAMALLENPNRPTAIFAGSDLQAMGVYEAARQNRLRIPEDLSVVGFDDVQTSAFLGPALTTVRQPLHDMAAVSTRMLIDTAEGRPTQHHVILPTTLVVRNSTHDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWD6</accession>
    <name>B8DWD6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Translation elongation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_0488</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218182.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0488"/>
    <dbReference type="EnsemblBacteria" id="ACL28787">
        <property type="protein sequence ID" value="ACL28787"/>
        <property type="gene ID" value="BLA_0488"/>
    </dbReference>
    <dbReference type="GeneID" id="66533621"/>
    <dbReference type="KEGG" id="bla:BLA_0488"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.518"/>
    <dbReference type="HOGENOM" id="CLU_002794_5_1_11"/>
    <dbReference type="OMA" id="GITIFSH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03711">
        <property type="entry name" value="Tet_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035650">
        <property type="entry name" value="Tet_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL28787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="656" mass="71996" checksum="497B6D9BAF7F3BFC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWM2</accession>
    <name>B8DWM2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Undecaprenyl-phosphate sugar phosphotransferase</fullName>
            <ecNumber evidence="9">2.7.8.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rfbP</name>
        <name evidence="9" type="ordered locus">BLA_0576</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.6" evidence="9"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0576"/>
    <dbReference type="EnsemblBacteria" id="ACL28873">
        <property type="protein sequence ID" value="ACL28873"/>
        <property type="gene ID" value="BLA_0576"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0576"/>
    <dbReference type="HOGENOM" id="CLU_024920_3_0_11"/>
    <dbReference type="OMA" id="ASFWTFG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047360">
        <property type="term" value="F:undecaprenyl-phosphate galactose phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="8">
        <location>
            <begin position="354"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL28873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="548" mass="62518" checksum="2669A86B39A09B81" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWN2</accession>
    <name>B8DWN2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218318.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28883">
        <property type="protein sequence ID" value="ACL28883"/>
        <property type="gene ID" value="BLA_0586"/>
    </dbReference>
    <dbReference type="GeneID" id="66533714"/>
    <dbReference type="KEGG" id="bla:BLA_0586"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.617"/>
    <dbReference type="HOGENOM" id="CLU_023845_6_0_11"/>
    <dbReference type="OMA" id="SNKCNFE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="295" mass="33461" checksum="E23CCC7832B49A6A" modified="2009-03-03" version="1">MTAAKFGFVVLHYLAGDATAGCIESIKTHCPQAVIVVVDNNSANGSYEELQRKYGADSTVTLLHNAVNEGFARGNNTGYEYARNRLHCDFIVTMNNDATISCDDFMELCEEDFKAHPDVGVIGPDIVSGKNGSHSNPIYSIIDTRAEVDRQIWRFKVILLLLHLHLFGPLTRLKAKLTHSDANALPEHVNATADAITGKPYKLHGACFVFTPAFVKQFSCAFDSGTFLYFEEDILLMRCRARHLTMWYDKRIRVDHMEDVSTDQMMRKDERRKMIFTLHNYVRSLKVLKQYVNSK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWR0</accession>
    <name>SYR_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="1">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argS</name>
        <name type="ordered locus">BLA_0618</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269231.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DWR0"/>
    <dbReference type="SMR" id="B8DWR0"/>
    <dbReference type="STRING" id="442563.BLA_0618"/>
    <dbReference type="EnsemblBacteria" id="ACL28911">
        <property type="protein sequence ID" value="ACL28911"/>
        <property type="gene ID" value="BLA_0618"/>
    </dbReference>
    <dbReference type="GeneID" id="66533749"/>
    <dbReference type="KEGG" id="bla:BLA_0618"/>
    <dbReference type="HOGENOM" id="CLU_006406_0_1_11"/>
    <dbReference type="OMA" id="NKPLHLG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000198874" description="Arginine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="598" mass="65586" checksum="7D962679DCF11F41" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWR1</accession>
    <name>B8DWR1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glucosylceramidase</fullName>
            <ecNumber evidence="6">3.2.1.75</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_0619</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.75" evidence="6"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219196.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0619"/>
    <dbReference type="CAZy" id="GH30">
        <property type="family name" value="Glycoside Hydrolase Family 30"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28912">
        <property type="protein sequence ID" value="ACL28912"/>
        <property type="gene ID" value="BLA_0619"/>
    </dbReference>
    <dbReference type="GeneID" id="66533750"/>
    <dbReference type="KEGG" id="bla:BLA_0619"/>
    <dbReference type="HOGENOM" id="CLU_014379_3_1_11"/>
    <dbReference type="OMA" id="IMINDDQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046557">
        <property type="term" value="F:glucan endo-1,6-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="PTHR11069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glyco_hydro_30" evidence="5">
        <location>
            <begin position="56"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL28912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="484" mass="53685" checksum="A2D93A8F689B3343" modified="2009-03-03" version="1">MIQAFSTYANAQGTTLAAAFAPLGNAYLRVGRTPESTSHASTPTLSIDTTRVRQPIDGFGASITEATSWLWHNRVTDKERCIRDLFSPRDGIGISMLRQPIGPSDHVSAPYRFVRRFPDRNLNSLDFTPEMERVLPMVEAANDCALATQSHALNIMASPWSAPWWMKTNLSVLGKRRYTRITGHLRRGMYAAYARYITGFARLYAQRGLPLFALTVTNEPDYPQSRWPSMAMTPREQAEFVARHLRPMLDHAGLEGTRILCWDHNYSTDHYPDGAFVRDMYADSAALTACAGSAWHYYGGSARTMSRIHDAFPNKGIWATEASGGDWGPRNFTPALLSLGTAVIDMMNNWARSAVLWNIALDEHGGPDYYYLRNDRRHSENRGLITVRDDGSIRRNADYYALGHFSKYVPIGSRCVECALDHAQGVRAAAFLVPAALTHGDGDQVVAVLVNSRPEPLDLLCHLRGAGNGVMLTLPASSLTSFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWV4</accession>
    <name>B8DWV4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chorismate mutase</fullName>
            <ecNumber evidence="2">1.3.1.12</ecNumber>
            <ecNumber evidence="2">5.4.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.1.12" evidence="2"/>
    <dbReference type="EC" id="5.4.99.5" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219127.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0662"/>
    <dbReference type="EnsemblBacteria" id="ACL28955">
        <property type="protein sequence ID" value="ACL28955"/>
        <property type="gene ID" value="BLA_0662"/>
    </dbReference>
    <dbReference type="GeneID" id="66533795"/>
    <dbReference type="KEGG" id="bla:BLA_0662"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.690"/>
    <dbReference type="HOGENOM" id="CLU_131518_0_0_11"/>
    <dbReference type="OMA" id="RFKCTQQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010951">
        <property type="entry name" value="CM_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01795">
        <property type="entry name" value="CM_mono_cladeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="129" mass="14715" checksum="E0A4B5F02F907638" modified="2009-03-03" version="1">MEQGASGSNETVIDSEQDWRDERTRDIVDKIETLRQSIDNVDMAIVALLAERFKYTSSVGVLKARAGFAPADYKREEEQMRRLRRLAIDAGLDPEIAEEYREFVVTEAKKRHKRIAETGEDPGVLDIFA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSK3</accession>
    <name>RL9_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplI</name>
        <name type="ordered locus">BLA_0689</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219094.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DSK3"/>
    <dbReference type="SMR" id="B8DSK3"/>
    <dbReference type="STRING" id="442563.BLA_0689"/>
    <dbReference type="EnsemblBacteria" id="ACL28982">
        <property type="protein sequence ID" value="ACL28982"/>
        <property type="gene ID" value="BLA_0689"/>
    </dbReference>
    <dbReference type="GeneID" id="66533822"/>
    <dbReference type="KEGG" id="bla:BLA_0689"/>
    <dbReference type="HOGENOM" id="CLU_078938_5_1_11"/>
    <dbReference type="OMA" id="MKIILTH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00651">
        <property type="entry name" value="RIBOSOMAL_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000196225" description="50S ribosomal protein L9">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <sequence length="148" mass="15694" checksum="A4921146DB4C0629" modified="2009-03-03" version="1">MATTKIILKKSVNNLGHAGDIVEVKAGYARNYLIPQGYAFPWTKGAAAQAEAMKRARLAKAIATREGAVEAKQIIEGTAVEIFAKVSESGKLFGGISNEQIANALAEKVAVDPKGITVEKIQTLGEFPATVALHPEISANFFVKVVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8DST5</accession>
    <name>B8DST5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable permease of ABC transporter for peptides</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BLA_0771</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619827.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0771"/>
    <dbReference type="EnsemblBacteria" id="ACL29064">
        <property type="protein sequence ID" value="ACL29064"/>
        <property type="gene ID" value="BLA_0771"/>
    </dbReference>
    <dbReference type="GeneID" id="66533533"/>
    <dbReference type="KEGG" id="bla:BLA_0771"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.803"/>
    <dbReference type="HOGENOM" id="CLU_028518_5_4_11"/>
    <dbReference type="OMA" id="WFAVLPN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="114"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="389"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="405" mass="43392" checksum="BA9E32C685DBEE0C" modified="2009-03-03" version="1">MSESTETRVGVPGDARLENPNIEKPQSWFAKLPVVRDLKIAVGWQKGMLVTGLVLTGFFLLVAVFAPWIAPYGYAQIKGDDGVAFPTQAAPSREHIWGTTVGGFDVFSRTVWGARTAVIAIVVAVLLSIFAGVFLGLVSGYFGGWVDRVFVVIADAVYSFPSLLLAILMAIMISGGQSSLWGGILASGISITVVYIPQYFRTIRAEVIRIKDSAYIESAKVVGASTWRIMSKHLLKNSTRTLPVILTLNSSEAILTLAGLGFLGFGIEPTAAAEWGYDLNRSVADVTSGIWWTAVFPGLAIVLIVLGITLIGESLNDLADPRLRARKSAGEVVGSIEDTSVDSPDSGPISQAVVEQEYAAIKDATEKPADLGEDVNEYLVTQDPETAVVNKDVPDESEGVIDNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8DST9</accession>
    <name>B8DST9_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="10">2.4.1.227</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">murG</name>
        <name evidence="13" type="ordered locus">BLA_0776</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1-&gt;4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:31227"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="ChEBI" id="CHEBI:61388"/>
            <dbReference type="EC" id="2.4.1.227"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 28 family. MurG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.227" evidence="10"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218651.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0776"/>
    <dbReference type="CAZy" id="GT28">
        <property type="family name" value="Glycosyltransferase Family 28"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29068">
        <property type="protein sequence ID" value="ACL29068"/>
        <property type="gene ID" value="BLA_0776"/>
    </dbReference>
    <dbReference type="GeneID" id="66533538"/>
    <dbReference type="KEGG" id="bla:BLA_0776"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.809"/>
    <dbReference type="HOGENOM" id="CLU_037404_1_0_11"/>
    <dbReference type="OMA" id="AADMMLC"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051991">
        <property type="term" value="F:UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050511">
        <property type="term" value="F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00033">
        <property type="entry name" value="MurG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006009">
        <property type="entry name" value="GlcNAc_MurG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01133">
        <property type="entry name" value="murG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0133">Cell shape</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 10 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="11">
        <location>
            <begin position="9"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="12">
        <location>
            <begin position="205"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetyl-alpha-D-glucosamine binding" evidence="10">
        <location>
            <begin position="16"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACL29068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="394" mass="41875" checksum="93FCB64DFBC39031" modified="2009-03-03" version="1">MSSNTQHRIMLAGGGTAGHVNPLLAVADAIRCLDPDADIIALGTAVGLEADLVPQAGYQLETIEKVPFPRRPNRAALEFPRKWKAEKAKVMQYLEHQGTQVVVGFGGYASAPAYSAAHRLGIPVVIHEQNARAGMANKLGARWAQFIGTAYDATGLKPAKDGGIERVGLPLRPAIANLAEELERDREGARTRNAAELGLDPNRPIIVVTGGSLGAQSINRAVAGSARQLTEVAQIVHLTGKGKIDEVRDLVVQNAGADVLTGLGEESRPGRNYHVAQYLERIDKAFACADLVICRSGAGTVSELTALGLPAVYVPLPIGNGEQRFNALPVSDAGGGIIVDDRSFTSQWVSAQVPGLLANPARLRSYGEHAWQYGIRDAADRMAREILSIADARV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSU2</accession>
    <name>MRAY_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="1">2.7.8.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">UDP-MurNAc-pentapeptide phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mraY</name>
        <name type="ordered locus">BLA_0779</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP</text>
            <dbReference type="Rhea" id="RHEA:28386"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="EC" id="2.7.8.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218646.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DSU2"/>
    <dbReference type="SMR" id="B8DSU2"/>
    <dbReference type="STRING" id="442563.BLA_0779"/>
    <dbReference type="PRIDE" id="B8DSU2"/>
    <dbReference type="EnsemblBacteria" id="ACL29071">
        <property type="protein sequence ID" value="ACL29071"/>
        <property type="gene ID" value="BLA_0779"/>
    </dbReference>
    <dbReference type="GeneID" id="66533541"/>
    <dbReference type="KEGG" id="bla:BLA_0779"/>
    <dbReference type="HOGENOM" id="CLU_023982_0_1_11"/>
    <dbReference type="OMA" id="LMSPLHH"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00038">
        <property type="entry name" value="MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00445">
        <property type="entry name" value="mraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_1000117164" description="Phospho-N-acetylmuramoyl-pentapeptide-transferase">
        <location>
            <begin position="1"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="2"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00038"/>
        </source>
    </evidence>
    <sequence length="368" mass="40042" checksum="490FE8D167A22E7C" modified="2009-03-03" version="1">MIALIIGILTSLIITLVGTPLLIRIVHKLNYGQYIRQDGPKSHQVKRGTPTLGGVVIVLAVVLGWCASALYRFCTTGARPTWAAILALFAMVSMGVLGFIDDFAKVRKKQNEGLTVGGKFFGQVVFATIFAVLALIVPTRSGFPVAQAGMSFIEKPFLSFEFAGRIVAIILFVIWVNFLMAAWTNAVNLSDGLDGLCAGSSMIAFVGYAIIAMWQMYHLKGQAHSGFTYAVSDPLDLGIIACCAAVACLGFLWYNCNPASIFMGDTGSLALGGLFAALSIITHTEFLAMIIGGLFVVETLSDVIQVGYFKATHKRVFKMAPIHHHFELCGWSESKVVVRFWIVELMFVITGLIIFYGNWVGLSGLWHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSU6</accession>
    <name>B8DSU6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269193.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0783"/>
    <dbReference type="EnsemblBacteria" id="ACL29075">
        <property type="protein sequence ID" value="ACL29075"/>
        <property type="gene ID" value="BLA_0783"/>
    </dbReference>
    <dbReference type="GeneID" id="66533545"/>
    <dbReference type="KEGG" id="bla:BLA_0783"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.816"/>
    <dbReference type="HOGENOM" id="CLU_110188_1_0_11"/>
    <dbReference type="OMA" id="VQKNINM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="176" mass="19315" checksum="EA7D861AF16FB9D1" modified="2009-03-03" version="1">MAVPMRSTRSNVSPAGRQSDPALKRPHLHVVESGEHHAKETGHGAHVASTVIAWTRSRPRPWLHTTIAILFLVLCWIGTLMLRTQMVENSFESSQVEQNITMLRQDVEDNQAKLSNLEATLPDRAQKLNMVPASGSLTIDLNGYQPPKDEKATTGESAEQQATSNQHDTSQGGATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSV4</accession>
    <name>B8DSV4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable cation efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BLA_0791</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218628.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0791"/>
    <dbReference type="EnsemblBacteria" id="ACL29083">
        <property type="protein sequence ID" value="ACL29083"/>
        <property type="gene ID" value="BLA_0791"/>
    </dbReference>
    <dbReference type="GeneID" id="66533553"/>
    <dbReference type="KEGG" id="bla:BLA_0791"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.824"/>
    <dbReference type="HOGENOM" id="CLU_013430_0_0_11"/>
    <dbReference type="OMA" id="RTWGWAR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="310" mass="33090" checksum="E5CAAC17A9BF7E5A" modified="2009-03-03" version="1">MAHEHSHAPVNGTEGHFKRLIVTLALTATILVAEVVGAALTGSLALLVDAGHMTTDVAVLTASTVTAALMRRKPDKSKTWGWARLEIITAAGGGLVLMFVGLYALIEAVLRLTGVESESVHDVRLLLFFGILGLASNIGSMFVLRAQSNDNMNMRAAFLEVCNDALGSVAVIISSIVLMCTGWSGFDAIAGALIALLMIPRAYGLLHHAMRVLLEETPDGLDLDTVREHLLGVPHVLAVHDLHASVVSTGMPILTAHVIVEPDLTVAQAGEVLRQLQDCTRQHFPVSIAHTTFQLEPEGYSNVDVGQIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSV7</accession>
    <name>B8DSV7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 16S RNA G1207 methylase RsmC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0794"/>
    <dbReference type="EnsemblBacteria" id="ACL29086">
        <property type="protein sequence ID" value="ACL29086"/>
        <property type="gene ID" value="BLA_0794"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0794"/>
    <dbReference type="HOGENOM" id="CLU_018398_7_0_11"/>
    <dbReference type="OMA" id="HMIDVNE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="57"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="231" mass="24805" checksum="AC21A17FBD1A7905" modified="2009-03-03" version="1">MVRIVNKTGTANISVFHGNGDVMGKSNGTANEQYFSSAPQSADVRKTLEVTLRDHPVTVETSNGVFSAHRVDLGTSVLLRHAPMPPLEGTFLDLGCGWGAIALALALESPEATVYAVDVNERAIELARSNAEANGCGNIHAGTAAVVPGDVRFDVIWSNPPIRIGKEALHELLMEWLPRLVSDGHAYLVVQRNLGSDSLIPWLAEHLGDGYEVGKYASSKGYRVIDVHKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSW9</accession>
    <name>B8DSW9_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_0806</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218605.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0806"/>
    <dbReference type="EnsemblBacteria" id="ACL29098">
        <property type="protein sequence ID" value="ACL29098"/>
        <property type="gene ID" value="BLA_0806"/>
    </dbReference>
    <dbReference type="GeneID" id="66533568"/>
    <dbReference type="KEGG" id="bla:BLA_0806"/>
    <dbReference type="HOGENOM" id="CLU_016902_4_4_11"/>
    <dbReference type="OMA" id="AHPSPGW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="14"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="317" mass="35141" checksum="F9BE4255F76963E1" modified="2009-03-03" version="1">MSTIIPAPDALIGKRFDVAVAKMMGISRAKATELIETGQARVIGRDIHKSATLQAGDTVEIDVREERREPEPVSNEMTIAYEDDDIVVVDKPVGVAAHASVGWTGPTVLGSLIQRGVHITSMGAAGRQGIVSRLDVGTSGLMLVCKSDLAYKEMRRQFSEHEVKKTYHALVQGNLKEDKATIEAPIGRAKVSDFRFTVTPAGKEAVTHWDVMERFGEATLASINLETGRTHQIRVHFSSIGHPLVGDPMYGANPRLSQALGLERQWLHAMELEFRHPRTHINTVVTSRYPTDLQHALETERERFAQREHQRLESSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSX8</accession>
    <name>B8DSX8_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Thiamine-phosphate synthase</fullName>
            <shortName evidence="14">TP synthase</shortName>
            <shortName evidence="14">TPS</shortName>
            <ecNumber evidence="14">2.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Thiamine-phosphate pyrophosphorylase</fullName>
            <shortName evidence="14">TMP pyrophosphorylase</shortName>
            <shortName evidence="14">TMP-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">thiD</name>
        <name evidence="14" type="synonym">thiE</name>
        <name evidence="17" type="ordered locus">BLA_0815</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.</text>
    </comment>
    <comment type="function">
        <text evidence="6 14">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 14">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 14">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 14">
            <text>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP = 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP</text>
            <dbReference type="Rhea" id="RHEA:19893"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9 14">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="14"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218592.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0815"/>
    <dbReference type="EnsemblBacteria" id="ACL29107">
        <property type="protein sequence ID" value="ACL29107"/>
        <property type="gene ID" value="BLA_0815"/>
    </dbReference>
    <dbReference type="GeneID" id="66533577"/>
    <dbReference type="KEGG" id="bla:BLA_0815"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.849"/>
    <dbReference type="HOGENOM" id="CLU_020520_5_0_11"/>
    <dbReference type="OMA" id="HSGKERR"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 14" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="10 14 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TMP-TENI" evidence="15">
        <location>
            <begin position="17"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Phos_pyr_kin" evidence="16">
        <location>
            <begin position="266"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="HMP-PP binding" evidence="14">
        <location>
            <begin position="47"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="14">
        <location>
            <begin position="156"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="14">
        <location>
            <begin position="215"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00000876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00004769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ACL29107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="516" mass="54334" checksum="BA2BECA74309264A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSZ8</accession>
    <name>B8DSZ8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0835"/>
    <dbReference type="EnsemblBacteria" id="ACL29127">
        <property type="protein sequence ID" value="ACL29127"/>
        <property type="gene ID" value="BLA_0835"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0835"/>
    <dbReference type="HOGENOM" id="CLU_023286_0_0_11"/>
    <dbReference type="OMA" id="DNNRIMQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="2">
        <location>
            <begin position="130"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="501" mass="53911" checksum="7F475CA60E0581FE" modified="2009-03-03" version="1">MSERSNLKLAALASATMPNVSVAGVRDSEQDNDTDRAVGIEQAVVQDMRGRLFNVYAAYDPRGKKRLHARGRAAAVVDRSREFAGLGFGTEHVLAFHAGKEGPEDASVLITTHPDGVARSLELLTIDDCSSFGTALGAIHRLRQNFITDAHYPVFTTGQIHAQLTAWIKRLRQAGHVPQEITSRWGGIMETEGLWSFSTRPVHGGFSDGDLIYSGSSITAITNWQDMQINDPARDLAWVFAKLDETHRNAVITAYGRVLGNRLDDLIMLRANLWVQMEQVGDFIKALNAGDNDRIMEFKAQVDRLAHKLGVSARAAHTARPASDAAATSGNAPSTVTVNTLLREDSRTAAPASSAGFPDDSTNETDVTGSRSYSQVMDDRTNSHPVAAVDDSTNDSPVLSSETVIIGINDSSSRGTQIVREEDFHYADDDTIGDRTDSTASAVAASRSDAETTVIPLLEREERAMRDARAGLEGTQGPDSGAGTQAVSTDGSSDDLDRTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT08</accession>
    <name>B8DT08_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Permease of ABC transporter system for amino acids</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BLA_0845</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218547.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0845"/>
    <dbReference type="EnsemblBacteria" id="ACL29137">
        <property type="protein sequence ID" value="ACL29137"/>
        <property type="gene ID" value="BLA_0845"/>
    </dbReference>
    <dbReference type="GeneID" id="66533607"/>
    <dbReference type="KEGG" id="bla:BLA_0845"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.880"/>
    <dbReference type="HOGENOM" id="CLU_019602_1_0_11"/>
    <dbReference type="OMA" id="YYILPRQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="20"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="224" mass="25141" checksum="46FF4D9F30FE5171" modified="2009-03-03" version="1">MQGANILLEPGVFPRLLQGLWVTIWIAAVSVGLSIPLGLLCGWLMTLRNPVIRFVMRVYLDFIRIMPQLALLFIAFYGIARMSNWNMDATASCVFVFVLWGGAELGDLVRGALQSIPQIQYETSYMLGLSNWQAFVHVILPQAVRRLLPGAVNLSTRIVKTTSLAVLLGVVEVIKVGQQIIDANRFQYPTGTLWVYGVIFLMYFIVCWPLSLVAHALEKRWAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT26</accession>
    <name>B8DT26_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29155">
        <property type="protein sequence ID" value="ACL29155"/>
        <property type="gene ID" value="BLA_0863"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0863"/>
    <dbReference type="HOGENOM" id="CLU_3325041_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="38" mass="4278" checksum="CFA7559D53F96BC3" modified="2009-03-03" version="1">MIIALPHTGHLRALTDFFLMPAAYPTPRKTRRINGTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT44</accession>
    <name>B8DT44_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-galactosidase</fullName>
            <ecNumber evidence="2">3.2.1.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.22" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219242.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0881"/>
    <dbReference type="CAZy" id="GH36">
        <property type="family name" value="Glycoside Hydrolase Family 36"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29173">
        <property type="protein sequence ID" value="ACL29173"/>
        <property type="gene ID" value="BLA_0881"/>
    </dbReference>
    <dbReference type="GeneID" id="66533860"/>
    <dbReference type="KEGG" id="bla:BLA_0881"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.921"/>
    <dbReference type="HOGENOM" id="CLU_018331_0_0_11"/>
    <dbReference type="OMA" id="VVFNDYM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038417">
        <property type="entry name" value="Alpga-gal_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00743">
        <property type="entry name" value="GLHYDRLASE36"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="773"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="798" mass="88195" checksum="45FF74AE03EC6996" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT58</accession>
    <name>B8DT58_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted phosphatase/phosphohexomutase</fullName>
            <ecNumber evidence="1">3.1.3.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.18" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0895"/>
    <dbReference type="EnsemblBacteria" id="ACL29187">
        <property type="protein sequence ID" value="ACL29187"/>
        <property type="gene ID" value="BLA_0895"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0895"/>
    <dbReference type="HOGENOM" id="CLU_045011_13_1_11"/>
    <dbReference type="OMA" id="LWDNDGL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="227" mass="24661" checksum="1C0283E9C6ED1AD2" modified="2009-03-03" version="1">MLKAVFWDMDGTLIDSEPYWHAGEMQIAHENGGVWNDELAWNGSGRPVPDVAREIAEHGCTLPVEEIGRRMIEYVTRAEYERIPWIPGTRELLVALRDAGVPSVLVTTSPRNLAENLIAQAPAGTFAGYVCGEDDVAKKPDPAPYVEAARRLDIPRADMPQCVAFEDSMSGLTSAAASGATTIAQLGFIRTDNSDGPQYMSIDGYDGVTPESLNAVVERRIAELAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT64</accession>
    <name>B8DT64_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC transport system membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219265.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0901"/>
    <dbReference type="EnsemblBacteria" id="ACL29193">
        <property type="protein sequence ID" value="ACL29193"/>
        <property type="gene ID" value="BLA_0901"/>
    </dbReference>
    <dbReference type="GeneID" id="66533881"/>
    <dbReference type="KEGG" id="bla:BLA_0901"/>
    <dbReference type="HOGENOM" id="CLU_074054_1_0_11"/>
    <dbReference type="OMA" id="CEVPYDL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008875">
        <property type="entry name" value="TraX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05857">
        <property type="entry name" value="TraX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="257" mass="28830" checksum="26274E19AC5A97D1" modified="2009-03-03" version="1">MVDEYTRHLERNKEVKGKGLSQFRMKVLADVLLFFSPFSVAVLPHIVGTPSRENMFALSVCVIGEAISWASIPMFAWLLYQGFEWTGNAWLYGLRLLVLALVCEVPYDYVVFGSAFDMRSQNPVFGLVVALIVLGILDLMYAWRTSVLKVVLSAGVIIIGLLWDFMLSIGQTQRLMNVGIVTLGMCVTYYYLHSRENTMVFTAAIFGAACVLTPGLGAVALHYRNDKLGYTHRWTRWAFYPVYPIMLVLCAAIGMAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT84</accession>
    <name>B8DT84_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable ATP binding protein of ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_0921</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217576.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0921"/>
    <dbReference type="EnsemblBacteria" id="ACL29213">
        <property type="protein sequence ID" value="ACL29213"/>
        <property type="gene ID" value="BLA_0921"/>
    </dbReference>
    <dbReference type="GeneID" id="66533465"/>
    <dbReference type="KEGG" id="bla:BLA_0921"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.964"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="QAFMHDP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="16"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="329" mass="36615" checksum="E034026C7EBB3703" modified="2009-03-03" version="1">MNTAENNVQRDAAPAIEVRELVKRYADKLALDYLNMNVRTGEIYGLLGPNGSGKTTAINCILGLLTYDSGQIRAFGGKMGPTAYDLKRRIGVVPQDVAVFNELTVQENIEYFCSLYVADKMRRARLVDEAIEFVGLEDYRRFRPRKLSGGLPRRLNIACGIVHQPEPIFFDEPTVAVDPQSRNSILEGIKRLNERGATVVYTSHYMEEVEQICDRIQIIDHGRQIAIGTADELKRMIEAGERITVEAPALSANEALCQRAVSMLGDLEAVHEVTFENDELVVVCSQGEHNLIDVLQVLRSLDIPMGHVSSRAPTLNDVFLALTGTDLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT97</accession>
    <name>B8DT97_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7 8">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 13" type="primary">recA</name>
        <name evidence="13" type="ordered locus">BLA_0934</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the RecA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217592.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0934"/>
    <dbReference type="EnsemblBacteria" id="ACL29226">
        <property type="protein sequence ID" value="ACL29226"/>
        <property type="gene ID" value="BLA_0934"/>
    </dbReference>
    <dbReference type="GeneID" id="66533452"/>
    <dbReference type="KEGG" id="bla:BLA_0934"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.977"/>
    <dbReference type="HOGENOM" id="CLU_040469_3_2_11"/>
    <dbReference type="OMA" id="DYGEQAL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="RECA_2" evidence="11">
        <location>
            <begin position="54"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="12">
        <location>
            <begin position="218"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="352"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="84"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACL29226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="382" mass="41008" checksum="2396A0B6E3D2EB29" modified="2009-03-03" version="1">MAARSKSSVKETEKTEAPGVDKKREDALNSALAQVEKQFGKGSAMRLGDRPEQDIEVIPTGSLALDTALGIGGLPRGRIVEIYGPESSGKTTLALHVVANAQKNGGVAAFIDAEHALDPVYARHLGVDTDSLIVSQPDNGEQALEIADMLIRSGALDVIVIDSVAALVPKAEIEGDMGDSHVGLQARLMSQALRKMTGALAQANTTAIFINQLREKIGVFFGSPETTTGGKALKFYASVRMDIRRIQTLKDKDEPIGNRTRVKVVKNKMAPPFKTAEFDMLYGQGISQEGSILDMALETDVVRKSGSWFTYNGEQLGQGRENVRKFLIDNPKLAEEISTQVKVKTGLISTDDQFGVDGTEEENGESITTSESNAEAQTSAEA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTA0</accession>
    <name>SECA_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="1">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">secA</name>
        <name type="ordered locus">BLA_0937</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + cellular proteinSide 1 = ADP + phosphate + cellular proteinSide 2.</text>
            <dbReference type="EC" id="7.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">May bind 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SecA family.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269150.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DTA0"/>
    <dbReference type="SMR" id="B8DTA0"/>
    <dbReference type="STRING" id="442563.BLA_0937"/>
    <dbReference type="EnsemblBacteria" id="ACL29229">
        <property type="protein sequence ID" value="ACL29229"/>
        <property type="gene ID" value="BLA_0937"/>
    </dbReference>
    <dbReference type="GeneID" id="66533449"/>
    <dbReference type="KEGG" id="bla:BLA_0937"/>
    <dbReference type="HOGENOM" id="CLU_005314_3_0_11"/>
    <dbReference type="OMA" id="MVHYDVQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008564">
        <property type="term" value="F:protein-exporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000184214" description="Protein translocase subunit SecA">
        <location>
            <begin position="1"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="855"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="902"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="924"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="104"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="957"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="959"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="968"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="969"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="974" mass="109037" checksum="9E9CC956752786F6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTA5</accession>
    <name>B8DTA5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probably bifunctional short chain isoprenyl diphosphate synthase</fullName>
            <ecNumber evidence="3">2.5.1.1</ecNumber>
            <ecNumber evidence="3">2.5.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">idsA</name>
        <name evidence="3" type="ordered locus">BLA_0942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.1" evidence="3"/>
    <dbReference type="EC" id="2.5.1.10" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217605.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0942"/>
    <dbReference type="EnsemblBacteria" id="ACL29234">
        <property type="protein sequence ID" value="ACL29234"/>
        <property type="gene ID" value="BLA_0942"/>
    </dbReference>
    <dbReference type="GeneID" id="66533444"/>
    <dbReference type="KEGG" id="bla:BLA_0942"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.985"/>
    <dbReference type="HOGENOM" id="CLU_014015_2_1_11"/>
    <dbReference type="OMA" id="LRALMCY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:geranyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="366" mass="39559" checksum="3DA19EA3B60D7A0F" modified="2009-03-03" version="1">MSDSSSIGAIETRIRELVHDYVGVNGTDAPITPALRPMFHTVVDQALASSEGGKRLRALLTLDAYDVLAGAPDSTQSRSVRTKVLDFACAIEVFQTAALVHDDLIDDSDLRRGKPSAHCALTSFAGARSIGRGLGLMLGDMLATACTLIMEDASTGMVEHRRLVEAFLSMQHDVEVGQVLDLAIERMPLDDPQALAEASLDVFRWKTASYTTIAPLMLAFLASGMTSEAANLHCHAIGLPLGQAFQLADDLLDVTGSSRSTGKPVGGDIREGKRTVLLADAMMLGTAAQRVQLQQLYEQPFRSDAQVHETIALFHDTGAIEHSHERIAKLWSQTQESIEAMGLTAAQSQSLRKACERFLPDFTAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTA7</accession>
    <name>B8DTA7_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor SigA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hrdB</name>
        <name evidence="5" type="synonym">sigA</name>
        <name evidence="9" type="ordered locus">BLA_0944</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts transiently with the RNA polymerase catalytic core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family. RpoD/SigA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0944"/>
    <dbReference type="EnsemblBacteria" id="ACL29236">
        <property type="protein sequence ID" value="ACL29236"/>
        <property type="gene ID" value="BLA_0944"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0944"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.987"/>
    <dbReference type="HOGENOM" id="CLU_014793_2_0_11"/>
    <dbReference type="OMA" id="SMEMTIE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00963">
        <property type="entry name" value="Sigma70_RpoD_SigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012760">
        <property type="entry name" value="RNA_pol_sigma_RpoD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028630">
        <property type="entry name" value="Sigma70_RpoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02393">
        <property type="entry name" value="RpoD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="447"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-2" evidence="5">
        <location>
            <begin position="254"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-3" evidence="5">
        <location>
            <begin position="333"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-4" evidence="5">
        <location>
            <begin position="422"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Interaction with polymerase core subunit RpoC" evidence="5">
        <location>
            <begin position="278"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL29236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="488" mass="54754" checksum="8BE844C8575A97F5" modified="2009-03-03" version="1">MVAKETTSTEKAAKKKASESAHDEAAVEEKGKTTRRRASSKASSAKKGSAGKTTKRATARKKKDAAESESTPARKTRAASKTGAKKAISKSEEIDDEDMIGEDVIDEEDLDLDEDLDADENDDDLEDEESEDEPEPEEDDDEEPQAPKEPKEKGAFVVSDNDEDDEALLANPGVNPKRRVVTTGATADPVKDYLKQIGRVSLLNAEQEVDLSERIEAGLYAQHLLDTEGDTMEFRRKRELKWAAADGKKAKDHLLEANLRLVVSLAKRYTGRGMLFLDLIQEGNLGLIRAVEKFDWKKGFKFSTYATWWIRQAITRAMADQARTIRVPVHMVEVINKLSRVQRQMLQDLGREPTPDELARELDMPVEKVQEVQKYGREPISLHTPLGEDGDSEFGDLIEDTDAIAPSEAVAFSLLQEQFRQVLETLSPREAGVIKMRYGLEDGQPKTLDDIGRVYGVTRERIRQIESKTMSKLRHPSRSQTLRDFLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTA9</accession>
    <name>B8DTA9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphatidyl-myo-inositol alpha-mannosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.57</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pimA</name>
        <name evidence="5" type="ordered locus">BLA_0946</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.57" evidence="5"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0946"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29238">
        <property type="protein sequence ID" value="ACL29238"/>
        <property type="gene ID" value="BLA_0946"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0946"/>
    <dbReference type="HOGENOM" id="CLU_009583_2_1_11"/>
    <dbReference type="OMA" id="MTIHNAR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="15"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="197"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="388" mass="42598" checksum="B50FAFD95C3215E8" modified="2009-03-03" version="1">MRIGFVFDDTLDVLDGVQQHIVTLGQELARRGHEVHYLVGETHDSPVPNTHPMSRNVMVRFNGNRMRIPLPANTRHIREVLDEYDFDILHVQAPYSPFMAARVLDHAHQRTGVVATYHIASADLASRIGGRALGLVNMHSHRRVDEVIAVSQIAAQYAEQTAHVRGVVIPNPVDVDRFAGASPTHAIVQGDTASAHSSEGPLAVFLGRFVPRKGAELLLDAVEYGEEHDLFPRGFHVRFAGKGPLLDECRERASHLRTPIEFLGFVEEEEKPKLLASADVAIFPATGGESFGIVLLEAIASNAGVTLAGDNPGYRSTMLDDEDSLFPVSGTDRARILAERIARALTDEPWAADLHAREAGLLDRYNVRTVTDQVEQVYGQAMAARHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTC2</accession>
    <name>B8DTC2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type transport systems, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_0961</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NlpA lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0961"/>
    <dbReference type="EnsemblBacteria" id="ACL29251">
        <property type="protein sequence ID" value="ACL29251"/>
        <property type="gene ID" value="BLA_0961"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0961"/>
    <dbReference type="HOGENOM" id="CLU_067080_1_1_11"/>
    <dbReference type="OMA" id="YQDDAES"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004872">
        <property type="entry name" value="Lipoprotein_NlpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30429">
        <property type="entry name" value="PTHR30429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03180">
        <property type="entry name" value="Lipoprotein_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="298" mass="32576" checksum="C193C89A407480EA" modified="2009-03-03" version="1">MAIVLAIVFGMRAVNKNDDSPKGSKNNPVVIGVVGATDPQWMEFTKQAEQQGVYVQIKDFQDYTSENPALAQGDLDMNEFQHLLYLANYNVQNKQNLQPLGGVAIYPLGVYSAFDKDGKPRYTDIKDLPAGSTVAIPNDETNQARAIGVLKAAGVVTLKGDWTAFTIPQDIDEAKSKVKVVPMKAEQIANTLKAGGDDLSAGVINNDYVADAGLKPTDAIYQDNAESEEARPYINIFAVRADDVNNEVYKKCVEIYQTKPVLDALQEESGGTAVFADKFSQQELASYLKQIETDIKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTF3</accession>
    <name>B8DTF3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proline iminopeptidase</fullName>
            <ecNumber evidence="3">3.4.11.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pap</name>
        <name evidence="3" type="ordered locus">BLA_0992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.5" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217669.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0992"/>
    <dbReference type="ESTHER" id="bifan-b2e8c8">
        <property type="family name" value="Proline_iminopeptidase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29282">
        <property type="protein sequence ID" value="ACL29282"/>
        <property type="gene ID" value="BLA_0992"/>
    </dbReference>
    <dbReference type="GeneID" id="66533395"/>
    <dbReference type="KEGG" id="bla:BLA_0992"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1035"/>
    <dbReference type="HOGENOM" id="CLU_024518_2_0_11"/>
    <dbReference type="OMA" id="TNEYEHN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="57"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="445" mass="50118" checksum="C487062B4ADB2BC1" modified="2009-03-03" version="1">MALLNEYYVPGLHVSEYAIDVPLDWDGHEPGMGFDGETIRLFYRVVCAPEHVNDRLPLLVFLQGGPGGAAPRPLSPDSDGWVAEAIKHFRVVLPDQRGTGRSSHIDSHTVANMDGRQAAEYLKKFLAGPIVRDFEHLRRTEFDGERWVTLGQSYGGFLTLTYLSLFPQSLIASFTTGGIPHVPASAREVYEHTFPRMQTKTEQFYARYPLDTKRVGCVADILRSTDVTLPNGDPFTVERLQTLGSSFGMKPAFERVHWLFDEAFLDGDGSANSDSPLADEFLFDAMTATYSNPLYWPLQEFIYADGDLDAPIDWAADHVYGSLPQFSTDARPLLFTGEAIFPWMFEQERALRPFRAAMDVLMQDTHFGVIYNVNQLAANTVPLNSAVYFDDLYVDSGLQLDTLSRIGNSHYWVTNEFEHDGVHGGIVFRHLFDEARDRGDLHELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTK2</accession>
    <name>B8DTK2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1043"/>
    <dbReference type="EnsemblBacteria" id="ACL29331">
        <property type="protein sequence ID" value="ACL29331"/>
        <property type="gene ID" value="BLA_1043"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1043"/>
    <dbReference type="HOGENOM" id="CLU_1275639_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="216" mass="22888" checksum="C9E4A998068B8F89" modified="2009-03-03" version="1">MTNNNATGNDLPPSFAPSHSKKGSAQPPVTSAPNASSPTPPSFTPGHISSPHNGRTSSAVPASFKPKHNRNPRSSSSSSSVVGSDSPRQPSPTTAPSYAPRRSPSRHQHSHQMPTNSRNGRFPAPAAMRNTATAATRKPHRVRNMVLGVLLVIVIVLGIGGIGTYDWVNSNLRKEAWLTTGSDTPGTSWLILGSDERDGTPVPMTPQVSVPTRFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTK9</accession>
    <name>B8DTK9_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="2">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_1050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1050"/>
    <dbReference type="ESTHER" id="bifan-b2eck9">
        <property type="family name" value="Carb_B_Bacteria"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29338">
        <property type="protein sequence ID" value="ACL29338"/>
        <property type="gene ID" value="BLA_1050"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1050"/>
    <dbReference type="HOGENOM" id="CLU_006586_16_4_11"/>
    <dbReference type="OMA" id="WNQGSDE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COesterase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="COesterase" evidence="3">
        <location>
            <begin position="368"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="466" mass="51086" checksum="F794F6C0A7AB6ADB" modified="2009-03-03" version="1">MRRQVTCEQGTLEGLAVGDPSITAFRGVPFAAPPVGPLRWRPPQSPAPWQGVRCAFDDAPACLQPIPGASNPFYDKEWGMDPAIPLDEDCLYLNIWTPALRGSGADARLTGESLPVMVWIHGGAYQCGCAMEKEFDGTALARQGVVVVSVAYRLNVFGFFSHRWLQEKAEEGAPYANFGWLDQQAALRWVRRNITVFGGDPTRICVFGQSAGAASVLAQCCAPSNAGLFSRAIMQSGAGLGYFNATLCSLESAQSTGARLMRRLGVENLDEARDVDAQTLFEGASRLEAPEGVDDAAWPMMVNWVPCVDGVFMPRQERDLILDGQTKNIDLVVGDTQDEFMVSDGQGHQVRAGREGNRRLIAAWQHGGGRAPYYYHFDVPMPGDDAGSFHSSDLWFVFGTLGSCWRPMRGCHVELSQCMSRYWTRFAAMGDPSGPGLVHWDRTDMHGDRFLHLGFPVEMRSGHRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTQ3</accession>
    <name>B8DTQ3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable ATP binding protein of ABC transporter for peptides</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">oppF</name>
        <name evidence="5" type="ordered locus">BLA_1094</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218805.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1094"/>
    <dbReference type="EnsemblBacteria" id="ACL29382">
        <property type="protein sequence ID" value="ACL29382"/>
        <property type="gene ID" value="BLA_1094"/>
    </dbReference>
    <dbReference type="GeneID" id="66532920"/>
    <dbReference type="KEGG" id="bla:BLA_1094"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1148"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_11"/>
    <dbReference type="OMA" id="TDWGFVR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="11"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="262" mass="28135" checksum="68DBBBE92ECA39AA" modified="2009-03-03" version="1">MIEEQQKPAALQANAAVKSFGRGRGRHQVLFDVNVEVWPGECLGIIGASGSGKSTLTRIMFGLEQPDSGDVLFNGVSILGASGRAQLRSLRAASGIVYQNPFASLDPRWTAGRSIAEPLRLAGERDERGIGGQVSRAMELVGLEPSEFMGRYPMDMSGGQAQRVAIARAVVKDPQVMLADEAMSAIDVAARMQILDAFAAIRERDPNMAMVLVSHDLGVVQNIADRIVVMHEGRVVESGPSAQILEQPQQEYTRLLIAAASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTS1</accession>
    <name>B8DTS1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218826.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1112"/>
    <dbReference type="EnsemblBacteria" id="ACL29400">
        <property type="protein sequence ID" value="ACL29400"/>
        <property type="gene ID" value="BLA_1112"/>
    </dbReference>
    <dbReference type="GeneID" id="66532935"/>
    <dbReference type="KEGG" id="bla:BLA_1112"/>
    <dbReference type="HOGENOM" id="CLU_013985_36_2_11"/>
    <dbReference type="OMA" id="HVKNRPD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="159" mass="17812" checksum="8CCB6A506B22DD87" modified="2009-03-03" version="1">MSNLTIRHANAGDIDAIMELLRQVNDVHAHGRPDLFIEGKTKYTPTELAQIIADDSRPIFVATDTDSTLLGYAFCMDENHAGANNLQPVRTLYIDDICVDERARGKHVGTELYDHVLDYARAHGYHNVTLNAWAANPAAVKFYESLGMSVYRYGMEQIL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTV0</accession>
    <name>PUR7_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="1">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purC</name>
        <name type="ordered locus">BLA_1141</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218868.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DTV0"/>
    <dbReference type="SMR" id="B8DTV0"/>
    <dbReference type="STRING" id="442563.BLA_1141"/>
    <dbReference type="EnsemblBacteria" id="ACL29429">
        <property type="protein sequence ID" value="ACL29429"/>
        <property type="gene ID" value="BLA_1141"/>
    </dbReference>
    <dbReference type="GeneID" id="66532965"/>
    <dbReference type="KEGG" id="bla:BLA_1141"/>
    <dbReference type="HOGENOM" id="CLU_061495_2_0_11"/>
    <dbReference type="OMA" id="EFCYKND"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01415">
        <property type="entry name" value="SAICAR_synt_PurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033934">
        <property type="entry name" value="SAICAR_synt_PurC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000122903" description="Phosphoribosylaminoimidazole-succinocarboxamide synthase">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <sequence length="250" mass="28060" checksum="51445C1FF445852B" modified="2009-03-03" version="1">MQKLDKLYEGKAKKLYATDDPDVLWVEYMNQATAGNGAKKAQIEGKGELNNQITSVIFDLLKARGIDSHFVKRISDTEQLVRKMDMYPLEIIMRNTAAGSFAKRYGVEEGTALDKPILEFCVKSDELGDPFINDDGIVALGIASEEELDEISRQARAVNDALKDIFSKIDVQLVDFKIEEGKTGDGRILLADEITPDTCRLWDLKDGSGQIEHLDKDLFRRDLGNIIPAYEEIYDRLVKLAEAEGVERAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU96</accession>
    <name>B8DU96_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29575">
        <property type="protein sequence ID" value="ACL29575"/>
        <property type="gene ID" value="BLA_1288"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1288"/>
    <dbReference type="HOGENOM" id="CLU_3196602_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="45" mass="4877" checksum="42320C82B37B4063" modified="2009-03-03" version="1">MESRSLRGWRRYGTSWDFLGWVASMAGSQTQDGEIVDAAVAADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUA5</accession>
    <name>B8DUA5_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uridylate kinase</fullName>
            <shortName evidence="6">UK</shortName>
            <ecNumber evidence="6">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Uridine monophosphate kinase</fullName>
            <shortName evidence="6">UMP kinase</shortName>
            <shortName evidence="6">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">pyrH</name>
        <name evidence="8" type="ordered locus">BLA_1297</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="6"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218010.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1297"/>
    <dbReference type="EnsemblBacteria" id="ACL29584">
        <property type="protein sequence ID" value="ACL29584"/>
        <property type="gene ID" value="BLA_1297"/>
    </dbReference>
    <dbReference type="GeneID" id="66533123"/>
    <dbReference type="KEGG" id="bla:BLA_1297"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1359"/>
    <dbReference type="HOGENOM" id="CLU_033861_0_0_11"/>
    <dbReference type="OMA" id="PIIVFDM"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_B">
        <property type="entry name" value="PyrH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02075">
        <property type="entry name" value="pyrH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="7">
        <location>
            <begin position="12"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="16"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="138"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="248" mass="26456" checksum="2EC731CE7195DBC4" modified="2009-03-03" version="1">MALENDLAQPRRVLLKLSGEAFGNGKVGVDTATIRRIAGEIVPAVEQGVQVAIVTGGGNFFRGAELQEAGIDRSRGDYMGMLGTVMNCLALQDFLEQAGQATRVQTAITMGQVAEPYIPLKAIRHLEKGRVVIFGAGAGMPYFSTDTVSIQRSLEIHCDEVLMGKNGVDGVYTADPRKDPSAQRFETLSYKRALIDNLAVMDASAMAMARDNNQTIRVFGLEGEGNVTRALMGDSIGTLVSNGDSSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUB1</accession>
    <name>B8DUB1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BLA_1303</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269089.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1303"/>
    <dbReference type="EnsemblBacteria" id="ACL29590">
        <property type="protein sequence ID" value="ACL29590"/>
        <property type="gene ID" value="BLA_1303"/>
    </dbReference>
    <dbReference type="GeneID" id="66533129"/>
    <dbReference type="KEGG" id="bla:BLA_1303"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1365"/>
    <dbReference type="HOGENOM" id="CLU_099748_0_0_11"/>
    <dbReference type="OMA" id="CGLFTPR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="8">
        <location>
            <begin position="6"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL29590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="252" mass="27099" checksum="90731780D33EC6BC" modified="2009-03-03" version="1">MSWHRTWLFARRTMKEIMRDPVNLFFGLAFPVLLLWALSLIYKQVGQIPGAATISGDELAAAISAYAPVFVSLFSGMLIAKDRTSSFLTRLFASPMTAADFTLGYSLPMLVVALAQSLVTFLFAGLFGHPIGVRMLLGAIVVLPTALMYTAIGLLCGTLMSDKAVGGVCGAMLTTIAFILAGVTVPIQIMGPTFQDIAKALPFYNAAQSAVAAVGGDYGRIWPHVWIVTAYAVGFWLAAVIVFGLRKRNVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUE4</accession>
    <name>B8DUE4_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit beta</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit beta</fullName>
            <shortName evidence="6">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">sucC</name>
        <name evidence="9" type="ordered locus">BLA_1338</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217962.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1338"/>
    <dbReference type="EnsemblBacteria" id="ACL29623">
        <property type="protein sequence ID" value="ACL29623"/>
        <property type="gene ID" value="BLA_1338"/>
    </dbReference>
    <dbReference type="GeneID" id="66533163"/>
    <dbReference type="KEGG" id="bla:BLA_1338"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1400"/>
    <dbReference type="HOGENOM" id="CLU_037430_4_0_11"/>
    <dbReference type="OMA" id="ITACDEV"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="PTHR11815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="9"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding; shared with subunit alpha" evidence="6">
        <location>
            <begin position="325"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL29623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="397" mass="42931" checksum="4EDF63FEFA3EA227" modified="2009-03-03" version="1">MDLYEYQARQLLEEQDIDVPKAVFAQNSHEVAEAADIIGYPVVIKAQVKIGHRGQAGGVRIAHDRDEAILISEDILPMTIHGHKVSGILVTEAKNILHEYYVSISVDRSSRDFDVLATANGGTEVEEVARKHPESVKRLHISALEDFDLEAATKMAESIGFYHADSAQAAQILLNMWRCFKQNDATLVEINPLAKVGDPDDESSKSLCALDAKISLDDNAAFRHDGWKRFADPIVPDPFEQRAREHNLHYVHLTGEVGVIGNGAGLVMSSLDAVAFAGEEQGTGVKAANFLDIGGGASSQVMCESLEIILSDPQVESVFINVYGGITSCEQVALGILEAADQLGASKPMVVRFEGNKADEGLRILAEADNPNIHVCETMGQAAAEAARLAAHGKEER</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUF0</accession>
    <name>Y1344_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable transcriptional regulatory protein BLA_1344</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">BLA_1344</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TACO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217954.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DUF0"/>
    <dbReference type="SMR" id="B8DUF0"/>
    <dbReference type="STRING" id="442563.BLA_1344"/>
    <dbReference type="EnsemblBacteria" id="ACL29629">
        <property type="protein sequence ID" value="ACL29629"/>
        <property type="gene ID" value="BLA_1344"/>
    </dbReference>
    <dbReference type="GeneID" id="66533169"/>
    <dbReference type="KEGG" id="bla:BLA_1344"/>
    <dbReference type="HOGENOM" id="CLU_062974_2_2_11"/>
    <dbReference type="OMA" id="ETIMYEG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01033">
        <property type="entry name" value="TIGR01033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_1000200078" description="Probable transcriptional regulatory protein BLA_1344">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <sequence length="251" mass="26769" checksum="FD9D0BD8B8956C95" modified="2009-03-03" version="1">MSGHSKWATTKHKKAAIDAKRGKLFAKLIKNIEIAARQGGGDPDGNPALYDAIYKAKKASMPADNIKRAVARGSGAEAGGANYEEIIYEGYAPAGVGLIIECLTDNRNRAAADVRSTLGKGGGSLATNGAVSFNFERKGEIVVPSEGLDFDDLFEKAAEAGAEDVIDDGDTYTVVTAPSDLITVRQALQDAGVDYDSADLVMRPKNEIELGLDDARKVSKLIDNLDDLDDVQNIYSNWTASDDVLAQLDEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUF4</accession>
    <name>SYT_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="1">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thrS</name>
        <name type="ordered locus">BLA_1348</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217949.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DUF4"/>
    <dbReference type="SMR" id="B8DUF4"/>
    <dbReference type="STRING" id="442563.BLA_1348"/>
    <dbReference type="EnsemblBacteria" id="ACL29633">
        <property type="protein sequence ID" value="ACL29633"/>
        <property type="gene ID" value="BLA_1348"/>
    </dbReference>
    <dbReference type="GeneID" id="66533173"/>
    <dbReference type="KEGG" id="bla:BLA_1348"/>
    <dbReference type="HOGENOM" id="CLU_008554_0_1_11"/>
    <dbReference type="OMA" id="FYYDFAY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000199528" description="Threonine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Catalytic" evidence="1">
        <location>
            <begin position="255"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="538"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01228"/>
        </source>
    </evidence>
    <sequence length="692" mass="78614" checksum="12385176C71E04B2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUH4</accession>
    <name>Y1368_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleotide-binding protein BLA_1368</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">BLA_1368</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Displays ATPase and GTPase activities.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RapZ-like family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ACL29653" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29653.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217920.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DUH4"/>
    <dbReference type="SMR" id="B8DUH4"/>
    <dbReference type="STRING" id="442563.BLA_1368"/>
    <dbReference type="EnsemblBacteria" id="ACL29653">
        <property type="protein sequence ID" value="ACL29653"/>
        <property type="gene ID" value="BLA_1368"/>
    </dbReference>
    <dbReference type="GeneID" id="66533199"/>
    <dbReference type="KEGG" id="bla:BLA_1368"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1432"/>
    <dbReference type="HOGENOM" id="CLU_059558_0_0_11"/>
    <dbReference type="OMA" id="TVMSFGF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00636">
        <property type="entry name" value="RapZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005337">
        <property type="entry name" value="RapZ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30448">
        <property type="entry name" value="PTHR30448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03668">
        <property type="entry name" value="ATP_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005052">
        <property type="entry name" value="P-loopkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000383217" description="Nucleotide-binding protein BLA_1368">
        <location>
            <begin position="1"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="83"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="310" mass="34470" checksum="FE634D979168751A" modified="2009-09-01" version="2">MQSARNEQRGTGPESPHAASPTEGFEVLLITGMSGAGRSHAAHSIEDMGWYVVDNMPPKLLEPMVDMMTASKSGFHKLAAVIDVRSRDYFMDLSSVLSHLDDLGLKTRILFLDADDNVLVKRFESVRRPHPLQQGNRLIDGIHEERRLLENLEERADIVINTSKLSIHQLSTKLYEALTGNGPTTVSVHIFSFGFKYGIPIDADFVADVRFLPNPYWVPQLRELNGHDAPVSEYVLSNDKATQFLDAYEKAIEIAIQGYAQEDKHYVTIAIGCTGGQHRSVAMSEALASRLRSHGLSVSVSARELDRKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUI0</accession>
    <name>B8DUI0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">T/U mismatch-specific DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217914.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1374"/>
    <dbReference type="EnsemblBacteria" id="ACL29659">
        <property type="protein sequence ID" value="ACL29659"/>
        <property type="gene ID" value="BLA_1374"/>
    </dbReference>
    <dbReference type="GeneID" id="66533204"/>
    <dbReference type="KEGG" id="bla:BLA_1374"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1438"/>
    <dbReference type="HOGENOM" id="CLU_094865_1_0_11"/>
    <dbReference type="OMA" id="QQYYAHP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026353">
        <property type="entry name" value="Hypoxan-DNA_Glyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04274">
        <property type="entry name" value="hypoxanDNAglyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="175" mass="19780" checksum="F41B01D94BC66520" modified="2009-03-03" version="1">MERFIHVEHGFGPCYAADSTRLFLGTMASPKSREAGFFYMHPRNRFWPIMQALFADPQDASDVVGDTPDSRRAFALRHRFALWDTVESCDIVGASDSSIRNVVPSDLSEIIRNSQISHIYACGQKADQLFHKYSEPMLECNGIHVSETALPSTSPAYASKTLDQLVDIYRERIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUI5</accession>
    <name>B8DUI5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bile salt hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_1379</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C59 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217908.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="SMR" id="B8DUI5"/>
    <dbReference type="STRING" id="442563.BLA_1379"/>
    <dbReference type="MEROPS" id="C59.951"/>
    <dbReference type="EnsemblBacteria" id="ACL29664">
        <property type="protein sequence ID" value="ACL29664"/>
        <property type="gene ID" value="BLA_1379"/>
    </dbReference>
    <dbReference type="GeneID" id="66533209"/>
    <dbReference type="KEGG" id="bla:BLA_1379"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1443"/>
    <dbReference type="HOGENOM" id="CLU_045206_1_1_11"/>
    <dbReference type="OMA" id="MCTRLVY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045302">
        <property type="term" value="F:choloylglycine hydrolase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CAFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029132">
        <property type="entry name" value="CBAH/NAAA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02275">
        <property type="entry name" value="CBAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBAH" evidence="3">
        <location>
            <begin position="2"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="314" mass="35023" checksum="9F8EC3802DA04F82" modified="2009-03-03" version="1">MCTAVRFDDGQNNMYFGRNLDWSEDYGEKIVFAPHDYHYAPAFNAEDKNHPVIGIGIIVEDTPLYFDCMNDAGLAVAGLNFAKYCKYATEAVNFTTNVAAYEFPLWVTRNFTSVDDVQEALKNVTIVGKPINDRFPVATLHWIIADNTRSIVVECTEDGMHVYDDDVDVLTNQPPFPQQIEHLDNYAYVSPRTGKSVKWGSSELETNQDSNSSQGLPGGYGSMARFVRAAYNNTHYPTQSGENANVNRLFKTLSTAAVIEGTAISANGEFEKTLFSDCYSTATQTVYLKKYDDMAVHSYAVKDFDASSNQLQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUJ9</accession>
    <name>B8DUJ9_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">OMP decarboxylase</fullName>
            <shortName evidence="7">OMPDCase</shortName>
            <shortName evidence="7">OMPdecase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">pyrF</name>
        <name evidence="9" type="ordered locus">BLA_1393</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the OMP decarboxylase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217889.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1393"/>
    <dbReference type="EnsemblBacteria" id="ACL29678">
        <property type="protein sequence ID" value="ACL29678"/>
        <property type="gene ID" value="BLA_1393"/>
    </dbReference>
    <dbReference type="GeneID" id="66533223"/>
    <dbReference type="KEGG" id="bla:BLA_1393"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1457"/>
    <dbReference type="HOGENOM" id="CLU_060704_1_1_11"/>
    <dbReference type="OMA" id="ARMPHTF"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01215">
        <property type="entry name" value="OMPdecase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011995">
        <property type="entry name" value="OMPdecase_type-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375">
        <property type="entry name" value="PTHR43375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02127">
        <property type="entry name" value="pyrF_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="8">
        <location>
            <begin position="14"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL29678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="316" mass="33804" checksum="A9A79B58A7B26F12" modified="2009-03-03" version="1">MDRLIEAIEDKQNPSVVGLDPTDKLVPAPVMDAYAVEAEEQVESDDNLAATAAAAAYFEFNRAIIDAVYDIVPAVKPQIAMYEALGPAGIDCYTMTCEYAQSRGLYVIGDVKRGDIGSTAAAYAHHLTGFQGDDVWFEDAVTVNPYLGSDGIEPFMEAAGQADRDMFILVRTSNPSSSQIQELELADGGRVYEHVADLVEDWGKDSIGRFGYSRAGAVVGATHPKEGAALRERMPHTFFLVPGYGAQGGTAQSVAGMFDHNGSGAIVNSSRGIIGAWRNDEQYSDSLEPESALELVAVNARAAAADMRDQLRVALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUK0</accession>
    <name>B8DUK0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dihydroorotase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pyrC</name>
        <name evidence="7" type="ordered locus">BLA_1394</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217888.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="SMR" id="B8DUK0"/>
    <dbReference type="STRING" id="442563.BLA_1394"/>
    <dbReference type="EnsemblBacteria" id="ACL29679">
        <property type="protein sequence ID" value="ACL29679"/>
        <property type="gene ID" value="BLA_1394"/>
    </dbReference>
    <dbReference type="GeneID" id="66533224"/>
    <dbReference type="KEGG" id="bla:BLA_1394"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1458"/>
    <dbReference type="HOGENOM" id="CLU_015572_1_0_11"/>
    <dbReference type="OMA" id="QHAQEPR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01317">
        <property type="entry name" value="DHOase_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004722">
        <property type="entry name" value="DHOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="35"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="474" mass="51687" checksum="EC1C6F4F712E66E4" modified="2009-03-03" version="1">MAITFTDITVWDTGEHIDLTVPDPRDVTIDASALTVAPGFEDPHVHFRDPGQTYKESMVSGCMAAASGGYTNVLIMPNTVPAMDGLQVHEGEPGAQEILDAGYHTVIDYLQHYEQIHHVTLPVRYELCVCATKGRAGLEPTDPKDWAWYMPGHDSEKDPAQIAHPVTAMSDDGSAVPEPVLRQVFDNVKSTGLYLIEHCEHHDVGAVNEGPVSHALNVPGIPEDTELAIVQRDIDLVRETGVHVHFQHVSTAISFDAIRNAKAEGLPITCETAPHYLALNDEALLEYGTLAKMNPPLRGERDRLATIKAIEDGTVDMIATDHAPHTLEEKARGFLEAPNGIIGLECAYAVCHKVLVDGGHISDQRLIELMSLNPAQLMGRHSTDIAALLNTSSKCAVKRSLNLAEVEHPELVDLNILNTTEQWSIDAGRFLSKARNTPFNGWDVSGKPYATIIASALVFDRLGFDEATETETGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUK7</accession>
    <name>B8DUK7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphohistidine phosphatase SixA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1401"/>
    <dbReference type="EnsemblBacteria" id="ACL29686">
        <property type="protein sequence ID" value="ACL29686"/>
        <property type="gene ID" value="BLA_1401"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1401"/>
    <dbReference type="HOGENOM" id="CLU_084603_2_0_11"/>
    <dbReference type="OMA" id="RTRETWK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="179" mass="19840" checksum="2D934FCD6DCAD45E" modified="2009-03-03" version="1">MAKRAKEYKHVLIIMRHAKTEAFNAKGDFERVLTDKGLKQAKRVAKGLRDMGLVPDQIDCSSATRAMQTCERMLKVFGDAPKVDYYQDLYAKGMQAVFDMLAACKDKRHALLVLGHEPTVSLASQWLAGEQSDPGQLDLLNLGMSTAGVAIFGSNAPFRKWGTHEANLIAVLTPKEFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUM9</accession>
    <name>B8DUM9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PhoH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">phoH</name>
        <name evidence="5" type="ordered locus">BLA_1423</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217851.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1423"/>
    <dbReference type="EnsemblBacteria" id="ACL29708">
        <property type="protein sequence ID" value="ACL29708"/>
        <property type="gene ID" value="BLA_1423"/>
    </dbReference>
    <dbReference type="GeneID" id="66533252"/>
    <dbReference type="KEGG" id="bla:BLA_1423"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1487"/>
    <dbReference type="HOGENOM" id="CLU_051654_0_0_11"/>
    <dbReference type="OMA" id="EAYEAWE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoH" evidence="4">
        <location>
            <begin position="145"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="354"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="387" mass="42778" checksum="94FE463E2EFD4EEF" modified="2009-03-03" version="1">MATTTRTVDIPEQLDSVKVLGVYDEVIREIEREYKEITVHVRGNRITITSTSRQGEREASQAQELIRALIDAAYTSPLDAATVRRMLEQQVLHNDVRDEVPGHGPTVQKLRRFKEHERTQARQIESVHRKPSVPGTITYAAGYPVRPKTSGQIAYVNAIESNTITFGIGPAGTGKTYLAVAKAVSDFEEGRVRRIILTRPAVEAGENLGFLPGTLNEKVDPYLRPLYDALSDMLGAERMKRYLDDGTIEVAPLAYMRGRTLNDAFVILDEAQNTTSQQMKMFLTRLGFNTKMVITGDITQVDLDVPRSGLASIESILGGIDDIAFVHLGASDVVRHALVGRIVAAYESHDDAARRRKGGKDARITHTAAPGRGDDDDRNAMVVDDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUN9</accession>
    <name>B8DUN9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FeS assembly protein SufD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">sufD</name>
        <name evidence="1" type="ordered locus">BLA_1433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217838.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1433"/>
    <dbReference type="EnsemblBacteria" id="ACL29718">
        <property type="protein sequence ID" value="ACL29718"/>
        <property type="gene ID" value="BLA_1433"/>
    </dbReference>
    <dbReference type="GeneID" id="66533263"/>
    <dbReference type="KEGG" id="bla:BLA_1433"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1497"/>
    <dbReference type="HOGENOM" id="CLU_026231_6_0_11"/>
    <dbReference type="OMA" id="HAVWIGD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011542">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43575">
        <property type="entry name" value="PTHR43575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01981">
        <property type="entry name" value="sufD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="408" mass="44863" checksum="42EE53084C8E66A3" modified="2009-03-03" version="1">MADPKEINIPVADPNDPYAIPAAMPSSADTAPRSFEVETFPVPTRKQEDWRFTPVDRLSEFFDVFEPSGRTQVSVTMIDGSAVDGSKVDVRTVNMGEDLSGTVSMPNDRVSCVEWNSARESTIIELKQDLEHPVLVKVFGTDDALDALHLVIAADARVHADVVVEHYGNARLAEGVEIVTGEDSHISTTFIQEWDRGSKHVGNHRIHVGKEASLRHSQVTLGGDVVRIRMDQDFGGEHGELNMLGIYFVDPGEHIEHRTMVVHNEPECKSRVVYKGALSGKGAHSTWVGNALIQPTAPGTDSYELNRNLVLTPGAVADSEPNLEIENGNIVGAGHASSVGRFDDEELFYLESRGIPEKEARKLVVRGFFGELVEEIGIDEIATHLMQAIDRRLVRGENEAMTNVLEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUQ2</accession>
    <name>B8DUQ2_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">3-dehydroquinate dehydratase</fullName>
            <shortName evidence="7">3-dehydroquinase</shortName>
            <ecNumber evidence="5 7">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Type II DHQase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">aroQ</name>
        <name evidence="11" type="ordered locus">BLA_1447</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes a trans-dehydration via an enolate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homododecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="5 7"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217822.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1447"/>
    <dbReference type="EnsemblBacteria" id="ACL29731">
        <property type="protein sequence ID" value="ACL29731"/>
        <property type="gene ID" value="BLA_1447"/>
    </dbReference>
    <dbReference type="GeneID" id="66533277"/>
    <dbReference type="KEGG" id="bla:BLA_1447"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1513"/>
    <dbReference type="HOGENOM" id="CLU_090968_2_1_11"/>
    <dbReference type="OMA" id="AYTHYSY"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018509">
        <property type="entry name" value="DHquinase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="PTHR21272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001399">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="SSF52304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01029">
        <property type="entry name" value="DEHYDROQUINASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="110"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7 8">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7 10">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL29731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="154" mass="17053" checksum="725F6CEAA65D0E13" modified="2009-03-03" version="1">MATKSQPIKVMVVNGPNLGRLGVRQPDVYGSQDLEELRRLCTRWGVEYGLDVDVRQTDDEAQMVHWMHEAADRRIAVVMNPAAFTHYSYALADAAHMVLDADLPLMEVHISNPAARDEFRKRSVISPVATGTITGLGYLGYKLALEAVAELTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUR5</accession>
    <name>B8DUR5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Xanthine/uracil permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pbuX</name>
        <name evidence="9" type="ordered locus">BLA_1461</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1461"/>
    <dbReference type="EnsemblBacteria" id="ACL29744">
        <property type="protein sequence ID" value="ACL29744"/>
        <property type="gene ID" value="BLA_1461"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1461"/>
    <dbReference type="HOGENOM" id="CLU_017959_8_0_11"/>
    <dbReference type="OMA" id="WANEMPL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017588">
        <property type="entry name" value="UacT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03173">
        <property type="entry name" value="pbuX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL29744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="476" mass="50402" checksum="796DCC3301E1E042" modified="2009-03-03" version="1">MRSDEDQERTFVTPELKRDERESKAEVAEEKRKGSISFEALSSLDAPVSFWKGIPFGLQHVLAMFVANLAPIFLVAAAGHMSPQDSAKIIQAGLLVAGLGTCLQLYGIWLFGSRLPMVTGISFTYVAAAISIVSHKGYGAVVGAVMVGGLLEVVLGLTARYWQRFVPPIVSAIVVTSIGFSLLSVGAESFGGGAGAEDFGSWQNLTLGLISLVACLAFQLFMKGTAKQLSVLFGLVVGYIVAIFFGKVDFSGFSHLQAVNVPTFMPFRPEFDWGSIISIGLLYIVSSVEVLGDTAALTKVGLDRKPTAKETSGAIAGDGLISSVSGLFGCLPLTSFAQNIGLVAMTKVVNRKVILSGGLLLVLASFVPAISEVFNSMPQAVLGGCTIMMFGNIILSGFQMISDAGYTQRNITIAALSLTIGIGFTQVSSIFVHFPPLFQSIFAQNCIAVAFVVAVVLNLVLPSEDRFLATPATNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUS0</accession>
    <name>B8DUS0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Possible amidotransferase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014482933.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1467"/>
    <dbReference type="EnsemblBacteria" id="ACL29749">
        <property type="protein sequence ID" value="ACL29749"/>
        <property type="gene ID" value="BLA_1467"/>
    </dbReference>
    <dbReference type="GeneID" id="66533297"/>
    <dbReference type="KEGG" id="bla:BLA_1467"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1535"/>
    <dbReference type="HOGENOM" id="CLU_030756_2_0_11"/>
    <dbReference type="OMA" id="PEYWAET"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011697">
        <property type="entry name" value="Peptidase_C26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044668">
        <property type="entry name" value="PuuD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43235">
        <property type="entry name" value="PTHR43235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07722">
        <property type="entry name" value="Peptidase_C26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="236" mass="26553" checksum="9BB8FFBEEC284604" modified="2009-03-03" version="1">MRPVVAVMPLVDDERESLWMLPGYMNALREAGAVPFMPALTTDRQEIGQIFGMCDGLVMTGGHDVNPACYGESDRYGNLHCCDARDEMELALLERAVASDKPVLGICRGLQIMNIFCGGTLYQDLPSEHPSDVDHHQHPPYGRPAHHVHILSRTPLREDLHDTDLAVNSRHHQAICKLGEGLDPMAISEDGLVEAIYRPRSAFYRAVQWHPEHLYKVDEPNRCIFRSFVNACTLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUT7</accession>
    <name>B8DUT7_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pta</name>
        <name evidence="5" type="ordered locus">BLA_1484</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.8" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217766.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1484"/>
    <dbReference type="EnsemblBacteria" id="ACL29766">
        <property type="protein sequence ID" value="ACL29766"/>
        <property type="gene ID" value="BLA_1484"/>
    </dbReference>
    <dbReference type="GeneID" id="66533314"/>
    <dbReference type="KEGG" id="bla:BLA_1484"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1553"/>
    <dbReference type="HOGENOM" id="CLU_019723_3_2_11"/>
    <dbReference type="OMA" id="CTIDRWP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008959">
        <property type="term" value="F:phosphate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004614">
        <property type="entry name" value="P_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042113">
        <property type="entry name" value="P_AcTrfase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042112">
        <property type="entry name" value="P_AcTrfase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002505">
        <property type="entry name" value="PTA_PTB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01515">
        <property type="entry name" value="PTA_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00651">
        <property type="entry name" value="pta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTA_PTB" evidence="4">
        <location>
            <begin position="236"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="560" mass="59933" checksum="D165B6383D1DAB09" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUT9</accession>
    <name>B8DUT9_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">aroA</name>
        <name evidence="9" type="ordered locus">BLA_1486</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014482946.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1486"/>
    <dbReference type="EnsemblBacteria" id="ACL29768">
        <property type="protein sequence ID" value="ACL29768"/>
        <property type="gene ID" value="BLA_1486"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1486"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1555"/>
    <dbReference type="HOGENOM" id="CLU_024321_0_0_11"/>
    <dbReference type="OMA" id="YEDHRMA"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00104">
        <property type="entry name" value="EPSP_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="17"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="30"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="7">
        <location>
            <begin position="101"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="183"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL29768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="462" mass="49302" checksum="AEEAF7ADABF20C70" modified="2009-03-03" version="1">MSMSEQNTTIWKAPVATAPIDATVTIPGSKSLSNRFLILAALSRKPVRIEGLLRSRDTELMMGALKALGVAFQEDATEPTTVTVIPPAEGFTGNTEVFCGLAGTVMRFVPPLTLFAKGPVRFDGDEQAYARPMGPVLEGMRQLGARIEFEGEEGHLPFTVTPPVQLGNLKGKPQKVRIDSSASSQFISGLLLIGSRLPDGLILEHTGVQLPSMPHIRMTMEDVDAAGGHIEMPQRGRWIVDHAELQMAAHVVVEPDLSNAAPFLGAALIASGSVRIPNWPAHTTQPGGFLPHILHRFGASITLGGEPFNEVNDCECFPDDYNGILEVSSDGVIEGLGECDLSAIGEITPSIAAIAVFANAPSVLVGIGHLRGHETNRLEALATEINRVGSDAQEEAEGLSIAPVARDLMHGAVMETYADHRMATFAAMLGLAIDGIEVTNVETTRKTIPDFVGMWNGMLRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUW7</accession>
    <name>B8DUW7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_1514</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268852.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1514"/>
    <dbReference type="EnsemblBacteria" id="ACL29796">
        <property type="protein sequence ID" value="ACL29796"/>
        <property type="gene ID" value="BLA_1514"/>
    </dbReference>
    <dbReference type="GeneID" id="66533911"/>
    <dbReference type="KEGG" id="bla:BLA_1514"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1585"/>
    <dbReference type="HOGENOM" id="CLU_037628_6_4_11"/>
    <dbReference type="OMA" id="ICGPQNI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="349" mass="37907" checksum="41F17BFB566478B4" modified="2009-03-03" version="1">MAKKVTLHDIAIAANVADSTASKALTGTGRISAETRRRVRDIAAQFGYARPATKTRTGNGRTGLIGIVTPDRNGRFALPLLAGAERALGAHNHAALLMISQGVPALERSHINQLSAQGVDGLIIAGNTCNARHPIDPRIQNGLPTVYAYDPSDDPADCSLICDNEGAGRQAAEYLLGIGRRRIAIVGGLDFFQATIDRERGALDTLRMAGAAPLLVINDRWSEDWGERAAQLLLERDEMPDAVYCLNDEIARGMCRTLQMHGHRVPQDIAVIGHDNWDSVCVNVHPTLTSFDNELETMGRRAARHLLDAINGRPHHGVFQVESRLVIRESTDATRHDPLHGSGWRAGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUX1</accession>
    <name>B8DUX1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CTP synthase (UTP-ammonia lyase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1518"/>
    <dbReference type="EnsemblBacteria" id="ACL29800">
        <property type="protein sequence ID" value="ACL29800"/>
        <property type="gene ID" value="BLA_1518"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1518"/>
    <dbReference type="HOGENOM" id="CLU_052626_4_2_11"/>
    <dbReference type="OMA" id="CLATMIE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="125" mass="14624" checksum="88F535FC8C4F99FF" modified="2009-03-03" version="1">MLEYTDPRSENGGETLARSRFIERGLMIPQLQKEFPNPQNPEYPFRVDFIWILPNGRMIVAEYDGMTKYGNDRKTIANHVHREKLRDEALRQHGVTAIIHFDYEDLLNPNELIARLVAAGVPYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUX8</accession>
    <name>B8DUX8_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-specific adenosine deaminase</fullName>
            <ecNumber evidence="1">3.5.4.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mesJ</name>
        <name evidence="1" type="synonym">tadA</name>
        <name evidence="3" type="ordered locus">BLA_1525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:43168"/>
            <dbReference type="Rhea" id="RHEA-COMP:10373"/>
            <dbReference type="Rhea" id="RHEA-COMP:10374"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.33" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1525"/>
    <dbReference type="EnsemblBacteria" id="ACL29807">
        <property type="protein sequence ID" value="ACL29807"/>
        <property type="gene ID" value="BLA_1525"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1525"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1599"/>
    <dbReference type="HOGENOM" id="CLU_025810_3_2_11"/>
    <dbReference type="OMA" id="PCQMCAG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00972">
        <property type="entry name" value="tRNA_aden_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028883">
        <property type="entry name" value="tRNA_aden_deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14437">
        <property type="entry name" value="MafB19-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="152" mass="16321" checksum="53F56AE92CCB278B" modified="2009-03-03" version="1">MTQYAEAMGEALAQARMARSAGDVPVGAVVLDAHGEVIGRGRNLRERDADPLAHAEIVAMREAAAVRGNWNLADCTLVVTLEPCPMCAGACLQTRIGRIVFGGWDAKLGACGSVWDIPRDPHVGHEPEVYGGVCERECTALLAEFFHSRRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUZ0</accession>
    <name>B8DUZ0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1537"/>
    <dbReference type="EnsemblBacteria" id="ACL29819">
        <property type="protein sequence ID" value="ACL29819"/>
        <property type="gene ID" value="BLA_1537"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1537"/>
    <dbReference type="HOGENOM" id="CLU_1122863_0_0_11"/>
    <dbReference type="OMA" id="GAMTHAK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="247" mass="26495" checksum="DE17F48EBE0D5732" modified="2009-03-03" version="1">MSTPIDRIIAIGPEPVKETPQKEDNSGASNDEGQSADQSAGNSAGTNDKQSATENNTGDAAEPSAESSPTPSAQPSQQPGAKPSEQPTSKPTQSAQPTQKPSEQPTQQPSAQPTQQPKPTPTPTQKPTQQPEQPTPSNCRLCKPSPSAAQAYAAGAAAQYGWTGKNWEDLVKLWNRESSWLWYAENKSSGAYGIPQSLPGSKMAQFGENWKEDAAVQIDWGLNYIATHPKYGSPSKAWAHSEKYGWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUZ5</accession>
    <name>B8DUZ5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_1542</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1542"/>
    <dbReference type="EnsemblBacteria" id="ACL29824">
        <property type="protein sequence ID" value="ACL29824"/>
        <property type="gene ID" value="BLA_1542"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1542"/>
    <dbReference type="HOGENOM" id="CLU_044441_1_0_11"/>
    <dbReference type="OMA" id="SHPTAHE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="114"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="60"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="254" mass="28072" checksum="6AB865CB97690DD1" modified="2009-03-03" version="1">MPSHPTSHEAAQEQSGPSEDTVPNQARGTRRIPTPAQVAQAAHAARMMQALHATQPLYSSQPVPAQSTAVPAHPMRNAARRDPGKPTPAMMPQRRSTDRRSSFASLDAQELPVVREYSAGGLVFDAHGRVAIIARHSRSGHLEWCLPKGHIEKGETPQQTAVREIHEETGIIGEVVDSIATIDYWFTGTSQRVHKLVHHFALRQTGGELTVEGDPDHEAEDAIWVDFADLDDVLSYPNERKIAWLYARKLNRQA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV05</accession>
    <name>RL34_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmH</name>
        <name type="ordered locus">BLA_1552</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219015.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DV05"/>
    <dbReference type="SMR" id="B8DV05"/>
    <dbReference type="STRING" id="442563.BLA_1552"/>
    <dbReference type="EnsemblBacteria" id="ACL29834">
        <property type="protein sequence ID" value="ACL29834"/>
        <property type="gene ID" value="BLA_1552"/>
    </dbReference>
    <dbReference type="GeneID" id="66533950"/>
    <dbReference type="KEGG" id="bla:BLA_1552"/>
    <dbReference type="HOGENOM" id="CLU_129938_2_1_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_L34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020939">
        <property type="entry name" value="Ribosomal_L34_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00784">
        <property type="entry name" value="RIBOSOMAL_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000134426" description="50S ribosomal protein L34">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="44" mass="5311" checksum="E95F143BB3F22F91" modified="2009-03-03" version="1">MKRTFQPNNRRRHMKSGFRVRMRTRAGRALINRRRAKGRKSLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV13</accession>
    <name>B8DV13_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BLA_0008</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0008"/>
    <dbReference type="EnsemblBacteria" id="ACL28314">
        <property type="protein sequence ID" value="ACL28314"/>
        <property type="gene ID" value="BLA_0008"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0008"/>
    <dbReference type="HOGENOM" id="CLU_042608_0_0_11"/>
    <dbReference type="OMA" id="SEYNEHP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="7">
        <location>
            <begin position="53"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="8">
        <location>
            <begin position="198"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL28314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="373" mass="42648" checksum="22C95294A728D568" modified="2009-03-03" version="1">MFRYLGSFSQSFTLALMLWPFVSLLLTLPIVAFVYHRNHRLSFTSAFSAYVAVLYALGLVAFTMYPMPDDPTLFCATHNLAPQLDILRFIQDAQTGLYGVLQLVMNVVLFMPLGFMLCRWAGWRFWVTSAFALGCSIFIETSQLTGIWGIYPCAYRQFDVDDMLTNTLGAMLGYACALLYTKLVPKKAKQLTGTNTRPGFVHRMVSMCIDFLLIALVYVPLSILYIFLFYLVFKSTGDGHYVWLSLTVEPRVLDYMTWITAALSFLLFEVWIPWRHHGQTLGCRYTHMTIETRDRSRGQRIAFYAIRTLFFGVIFGGLATNHPIWGWTLLALLIFWLVKKCMPWDLVPGTDPQTPPTSPQPQVSTLPEPNLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV54</accession>
    <name>B8DV54_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP binding protein of ABC transporter for pentoses</fullName>
            <ecNumber evidence="6">3.6.3.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_0052</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.17" evidence="6"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0052"/>
    <dbReference type="EnsemblBacteria" id="ACL28355">
        <property type="protein sequence ID" value="ACL28355"/>
        <property type="gene ID" value="BLA_0052"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0052"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="TCIMITH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="16"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="259"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL28355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="300" mass="32133" checksum="ACC68C3EED79D761" modified="2009-03-03" version="1">MACCRPTGLQSLALLALGEDVHRHGAQEHKTLDRLHHCGVDAHDRQALVDDAHDQCADNGAGKSTLVHVLAGLEQPDAGSIAVGGETVRLDGVAKAIDLGIAPAFQQPQFCENLDVSANIFLGREMRQGFASRDDEGMYNKAREVLNTLSTSVRAGQSIASLSGGQRQTIAIARTLLNDPSLIVLDEPTASLSVTQTAEVLDYIVRLRSDDRSVIMVCHDLPNVFAVADRIVVMRLGEIRAVHNTSETSYEEDIAEIAGVGGSGTTPSRPCERASRARMPIARESHPRPSRGGDRDGTMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV61</accession>
    <name>B8DV61_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dehydrogenase or reductase protein</fullName>
            <ecNumber evidence="5">1.1.1.274</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_0059</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.274" evidence="5"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219340.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0059"/>
    <dbReference type="EnsemblBacteria" id="ACL28362">
        <property type="protein sequence ID" value="ACL28362"/>
        <property type="gene ID" value="BLA_0059"/>
    </dbReference>
    <dbReference type="GeneID" id="66532435"/>
    <dbReference type="KEGG" id="bla:BLA_0059"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.64"/>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_11"/>
    <dbReference type="OMA" id="AFKPGNE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050580">
        <property type="term" value="F:2,5-didehydrogluconate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="31"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="287" mass="32281" checksum="039210CCFDDE08BF" modified="2009-03-03" version="1">MSTLADQTPDIPLITLHDGSRIPQIGLGVLRIDDEGVVPVVESALAIGYRHIDGAAGYNNEEGVGRALAATGYNTGEQRESLWMTTKLRDSEQGYDSAMHAFDRSLELLQLDYVDMYMIHWPTPFDWRSGETWKAFAKLREDGRVRTLGVCNFMPEHLDRLYEETGEYPTVNQIELHPTWQQRDVVEYCHAHDIAVEAYSPMARGADLANGVIERIAEAHGVTPAQVILRWHIENGTIIIPKSVHTERQRENLDLFGFSLTPQEHAEIDALDGPTRAGHDPMTFTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV71</accession>
    <name>B8DV71_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28372">
        <property type="protein sequence ID" value="ACL28372"/>
        <property type="gene ID" value="BLA_0069"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0069"/>
    <dbReference type="HOGENOM" id="CLU_3388246_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="32" mass="3752" checksum="21E276011CEBE01D" modified="2009-03-03" version="1">MFEFILPYSADYGTAIEHLFARRCQTAAPRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVB8</accession>
    <name>B8DVB8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.284</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">adh</name>
        <name evidence="4" type="ordered locus">BLA_0116</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="4"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268943.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0116"/>
    <dbReference type="EnsemblBacteria" id="ACL28419">
        <property type="protein sequence ID" value="ACL28419"/>
        <property type="gene ID" value="BLA_0116"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0116"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.120"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_11"/>
    <dbReference type="OMA" id="TGWFGAV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106322">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase NAD activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106321">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase NADP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="13"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="347" mass="37214" checksum="C3347FADF0CAD8EE" modified="2009-03-03" version="1">MKAAVFVEPEHVGVREVERPRIEKPTDAIVRVLKACVCGSDLWWFRGISERPHNTLVGHEAIGIIDEVGADVHDMKPGDFVIVPFTHCCGHCEACEKGYDGNCFNMEPGGNAGYQAEYMRATWAGTALIKIPGTPADYTDEQIASLLALSDVMATGYHAAWSSRIEPGDTVVIYGDGAVGLCAVIGAKLLGAGRIIMMSRHEDRAALAREFGATDIVPERGDEAVARIMEMTNGAGADRVLECVGSEQSIESAVRSGRPGAYVSRVGVPHDNSIDVNALFWRNVSLTGGIASVATHDKSTLLKAVLDGEINPGKVFTASFDLDHVQQAYEAMDGRRAIKSMIDIAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVF8</accession>
    <name>B8DVF8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Probable permease protein of ABC transporter system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BLA_0157</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218470.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0157"/>
    <dbReference type="EnsemblBacteria" id="ACL28459">
        <property type="protein sequence ID" value="ACL28459"/>
        <property type="gene ID" value="BLA_0157"/>
    </dbReference>
    <dbReference type="GeneID" id="66532533"/>
    <dbReference type="KEGG" id="bla:BLA_0157"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.167"/>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_11"/>
    <dbReference type="OMA" id="MSVMMAT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="17"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="361"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="395"/>
            <end position="402"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL28459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="639" mass="70846" checksum="A8B6C6CE8FB2362C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVG2</accession>
    <name>B8DVG2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type 2 phosphatidic acid phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218473.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0161"/>
    <dbReference type="EnsemblBacteria" id="ACL28463">
        <property type="protein sequence ID" value="ACL28463"/>
        <property type="gene ID" value="BLA_0161"/>
    </dbReference>
    <dbReference type="GeneID" id="66532536"/>
    <dbReference type="KEGG" id="bla:BLA_0161"/>
    <dbReference type="HOGENOM" id="CLU_072573_3_3_11"/>
    <dbReference type="OMA" id="WPDPVDS"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="89"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="229" mass="25397" checksum="B0B1240C42DB84D1" modified="2009-03-03" version="1">MDSLFVRKHCWQIIGALSLIGALWFTIAVCRFHILGMDTAVYGWITAHVMTPGMTSVMRMLTQLSGSITVIVVAAVALAVLAVVKRWKIGVAVAVNLAGIYVLNEIIKHIVRRPRPDFPHLVFEQGYSFPSGHAMVSTAFYGFIVYLLYRYWHTARDSGARVGKIVAIVLLCLIPPVVMFTRVYLGVHYASDVCAGLLFAIAWLTLFYVPAMKRTLLKRASPAASPTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVG3</accession>
    <name>B8DVG3_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">thgA</name>
        <name evidence="6" type="ordered locus">BLA_0162</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218474.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0162"/>
    <dbReference type="EnsemblBacteria" id="ACL28464">
        <property type="protein sequence ID" value="ACL28464"/>
        <property type="gene ID" value="BLA_0162"/>
    </dbReference>
    <dbReference type="GeneID" id="66532537"/>
    <dbReference type="KEGG" id="bla:BLA_0162"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.171"/>
    <dbReference type="HOGENOM" id="CLU_051638_3_2_11"/>
    <dbReference type="OMA" id="RIKFVEF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039369">
        <property type="entry name" value="LacA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43017">
        <property type="entry name" value="PTHR43017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mac" evidence="5">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL28464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="211" mass="23926" checksum="605B30F7A6C45494" modified="2009-03-03" version="1">MSDMEDRMHTGEMYLPHDEQILARQFDCLERLYDFNQTRPHELDRRAELLHDMFAEIGDACYIEPPFHANFGGAHVHFGSDIYVNFNLTCVDDTHIYVGSHTMIGPNVTLATAGHPILPELRERGYQYNMPVRIGENCWIGAGVVVLPGVTIGDNVVVGAGSIVTRDLPSNVVAVGNPCHVLREVGERDREYYFKDRRIDWNEMRADEAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVG9</accession>
    <name>B8DVG9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0168"/>
    <dbReference type="EnsemblBacteria" id="ACL28470">
        <property type="protein sequence ID" value="ACL28470"/>
        <property type="gene ID" value="BLA_0168"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0168"/>
    <dbReference type="HOGENOM" id="CLU_093450_3_0_11"/>
    <dbReference type="OMA" id="IFQPWTI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011733">
        <property type="entry name" value="CHP02185_IM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09605">
        <property type="entry name" value="Trep_Strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02185">
        <property type="entry name" value="Trep_Strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="193" mass="20400" checksum="F3DDD9AB422B48A2" modified="2009-03-03" version="1">MTVADLINVGVFGAVYFALVGVAALASMAVFGVAGNILLPAIAAVLAGPVFMLMVARVRRFGAITLMGLMLGLFLFVSGHFATSLVTAIVFPLAADCIARFGAWRRPWALMLSYVVFSFGCTGPILPLWMMKDAYIASLERKGKDAAYIDALFGAVNGTTFVVAMVAIVIGALVGGLFGMRLMRRHFLKAAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVH5</accession>
    <name>B8DVH5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218491.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28476">
        <property type="protein sequence ID" value="ACL28476"/>
        <property type="gene ID" value="BLA_0174"/>
    </dbReference>
    <dbReference type="GeneID" id="66532549"/>
    <dbReference type="KEGG" id="bla:BLA_0174"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.184"/>
    <dbReference type="HOGENOM" id="CLU_1178407_0_0_11"/>
    <dbReference type="OMA" id="HDNTNTG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="236" mass="24077" checksum="351698F4980AC5C9" modified="2009-03-03" version="1">MAQHDNTNTEIIRPQGGSQTQAAADTAQIAHTQADAPTQPQGYAFDFAQQQGEQIPPSQGYAPQNGEQPFTTAANTAQPNMGGNGVPNNPQGGQMPMNGGAPGNRGTATLRGKPGGKTIGIIAAISLGCGLVAGIAGTAVTNAIYRSNEPSHSNMMMRGIGDRGFGEGDGDGESMPDFGSGNGSRNRRSYRADGQMPGMQDSDGANGESNGDARNRSQSNDSDSNADSGSSDSSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVH8</accession>
    <name>B8DVH8_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="5">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">ftsY</name>
        <name evidence="9" type="ordered locus">BLA_0177</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218494.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0177"/>
    <dbReference type="EnsemblBacteria" id="ACL28479">
        <property type="protein sequence ID" value="ACL28479"/>
        <property type="gene ID" value="BLA_0177"/>
    </dbReference>
    <dbReference type="GeneID" id="66532553"/>
    <dbReference type="KEGG" id="bla:BLA_0177"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.187"/>
    <dbReference type="HOGENOM" id="CLU_009301_1_3_11"/>
    <dbReference type="OMA" id="GIEATDY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54" evidence="8">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="45"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="272"/>
            <end position="279"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="355"/>
            <end position="359"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="417"/>
            <end position="420"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL28479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="466" mass="49585" checksum="61F8FFEF7757B609" modified="2009-03-03" version="1">MDTNTIYAIVIIAVIAVALIIGSWLIGRSRRNAINKSTEHAKAAADARLAAERAQAEQEEREAHEQAKEPAESGARQSSGGKPAEPTNEEKIEAEEPAISRAELEAQERERLSQTPPKLAAAEEVPGEESAQAESVVEDLAVVDEVPTPPAEQIEKPAGKKSRLQRLRERLSKSSNPFGKALFNILAKDQLSEADWEDVEDTLLLADVGAEASEELVDKLRTDARVTGESDPRQLRDALRSELLALVGPDMDRTLEAEKPDAKKPSVIIMVGVNGTGKTTTAGKLARLFVSEDKTVLLGAADTFRAAAADQLETWGAKVDVPVVRSDREGADPASVAFEASAKAKELGTDVLIIDTAGRLQNKANLMDELGKIRRVAEKNLPVDEVLLVLDATTGQNGMAQAKVFAEAIGITGVVLTKLDGSAKGGIVISVQKELGVPVKLVGVGEGPDDLAPFDPESFVDGILGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVI3</accession>
    <name>B8DVI3_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Replicative DNA helicase</fullName>
            <ecNumber evidence="3 11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">dnaB</name>
        <name evidence="13" type="ordered locus">BLA_0182</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the helicase family. DnaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 11"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218499.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0182"/>
    <dbReference type="EnsemblBacteria" id="ACL28484">
        <property type="protein sequence ID" value="ACL28484"/>
        <property type="gene ID" value="BLA_0182"/>
    </dbReference>
    <dbReference type="GeneID" id="66532558"/>
    <dbReference type="KEGG" id="bla:BLA_0182"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.192"/>
    <dbReference type="HOGENOM" id="CLU_005373_0_0_11"/>
    <dbReference type="OMA" id="IEFHARI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00984">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007692">
        <property type="entry name" value="DNA_helicase_DnaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007693">
        <property type="entry name" value="DNA_helicase_DnaB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00772">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="SSF48024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00665">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0639">Primosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="12">
        <location>
            <begin position="194"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACL28484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="459" mass="50509" checksum="7A89D3533F6C00FB" modified="2009-03-03" version="1">MADGFHNNTRTDTSANAAGLFDRVPPHDDNAEMATLGGMLMSKDAIGEVSQIVSVDDFYEPKHQTIYEAIIGKFSASEPADAVTVANRLSDSGDLDKVGGIDYLHSLIASVPTAANASYYAEIVHQRALLRRVIASGTKIAQLGYDAEGSQAQDVINMAQAEVYEMSTGRVRQDYAPVQAAVHDALDQIDSIQKGELQAGVPTGFQEIDEVTKGLQPGQMVVVAGRPAMGKSTLGVDFARSAAIHHHDTTILFSLEMSKVELAQRIISAETGVPLAALRNADDIDPNRWNTLNNFYARLQDAPLFIDDSPNMSLMEIRAKCRRLKQTNDLKLVVIDYLQLMTSGKAVESRQQEVSEFSRALKLLAKELEVPVVALSQLNRGPEMRNDKKPQLSDLRESGSIEQDADVVFLVHRPDFYDEEDRPGEADIIMAKHRNGPTRTFGLVFQGQYSRFSDMNREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVJ5</accession>
    <name>B8DVJ5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative septum site determining protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0194"/>
    <dbReference type="EnsemblBacteria" id="ACL28496">
        <property type="protein sequence ID" value="ACL28496"/>
        <property type="gene ID" value="BLA_0194"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0194"/>
    <dbReference type="HOGENOM" id="CLU_059351_0_0_11"/>
    <dbReference type="OMA" id="TSFHNIV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="335" mass="36239" checksum="55E2E5A4ACC3006C" modified="2009-03-03" version="1">MRDARARRPWQAESARRVPAYQPVHAMAEPACSPQLSPPARRTHAGAQHARMPVCATQAPCENVITLSGASGGAGTTTLAAMLTRELAKRENECAIVDADVRAGGGGLDVLLGIEHESGSRWHDIHAPLGELDGEALRRRLPHWDGVGVLAYNCWVQEEPAWFEMQAALQSLAQVSDAVVVDAGHGLEIEHVPALVEASHIVVAELTVLGLARAKAHIEWLRRNGERNMARAQEPPRPGEEWKPIVGVPGRVIGVLCVEPPAVAKGRGAVSLEEARKYLQMEHMECELMGPVRSDARLCGDILEGLGIRRVHRRNARVLGDVAEMVERACGIGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVJ6</accession>
    <name>B8DVJ6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II secretion system protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0195"/>
    <dbReference type="EnsemblBacteria" id="ACL28497">
        <property type="protein sequence ID" value="ACL28497"/>
        <property type="gene ID" value="BLA_0195"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0195"/>
    <dbReference type="HOGENOM" id="CLU_005379_8_3_11"/>
    <dbReference type="OMA" id="HDERVIT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="9"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="337" mass="36371" checksum="4099E718496F1BC6" modified="2009-03-03" version="1">MNFGPLKRLAADPRVTDILVTCDGAVWVERGLGIELEHPSIPLDSPAVVRRLAVQLCAQLGERLDDARPIADASGADGTRVHAVIAPVVPYGASISIRLPSRMSATMDALQQAGCWPAQWRPILDRLVLARANILITGSTGSGKTTLLKALLLNCRASERIVLVEEVRELQGLGNLNTVSLCARAKNVEGAGEVTMGDLVRSTLRMYPTRVVVGECRGEEVIDLMRVLNSGHCGGMSTLHASGVSRVPGRLISLGLLAHVEPNTMAGLADGAFDVVLHMERRPGKRYLAQIGMLCMVEGRLVGRTVCSWDGRGEPVAGEAWRPFAERWGTKRVPERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVL1</accession>
    <name>B8DVL1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Possible pre-pilin peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219310.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0210"/>
    <dbReference type="EnsemblBacteria" id="ACL28512">
        <property type="protein sequence ID" value="ACL28512"/>
        <property type="gene ID" value="BLA_0210"/>
    </dbReference>
    <dbReference type="GeneID" id="66532584"/>
    <dbReference type="KEGG" id="bla:BLA_0210"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.223"/>
    <dbReference type="HOGENOM" id="CLU_047107_0_0_11"/>
    <dbReference type="OMA" id="AMRQITA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="3">
        <location>
            <begin position="228"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="406" mass="43385" checksum="089DAA071067A474" modified="2009-03-03" version="1">MSEHDETNTNAQRAPHSASPAPSAPTHSTPADDTQWSVLQERAEVREDNLDSQTQDPRIAAQIDAARARGFVPLSESESERTAKNSPEDLQAQIEAGLTQVDPLMVRPRISSRILCGVIALVFALLAFGSYRLGVHTLKGQGYEDLVIGNFANYTPQWLLRHNLGLTDSVVVISVSISLGAIAVFVALLRRRWWLAGQLVAFAAVSFACARVLKPALPRPLLMQIHSSTANSAPSGHTMLAITAGLMLVCAVPRAWRAACALFAAAYSMLVGVFVIADKWHRPCDVLMAVFLVGALAMLMLLFTRRSGMDRPGKRVSSASVQIASTVLITLGICGFAYAGYIIWQIFPGLEYGVAWSTGGACMSAGVLVIAVNALVVGAVLAVRQLTASPLTRLGQIGAPPAPPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVL8</accession>
    <name>B8DVL8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase (AAA+ superfamily)-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219303.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0217"/>
    <dbReference type="EnsemblBacteria" id="ACL28519">
        <property type="protein sequence ID" value="ACL28519"/>
        <property type="gene ID" value="BLA_0217"/>
    </dbReference>
    <dbReference type="GeneID" id="66532591"/>
    <dbReference type="KEGG" id="bla:BLA_0217"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.230"/>
    <dbReference type="HOGENOM" id="CLU_041527_3_1_11"/>
    <dbReference type="OMA" id="ALEIFPI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="20"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="176"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="389" mass="44214" checksum="9CFE9BD0FC96D7DD" modified="2009-03-03" version="1">MPLIPRELEPMLLERARAYPAVTLTGPRQSGKSTLVREAFPDYDYVSLEDIDMRELAHDDPRSFLQRYSNHVILDEVQRVPELFSYMQRVMDERNEPGQFILSGSQNFLLLNSISQSLAGRVAILHLLPLSYTELTHAGETPSNDEFVFRGGYPRLYSSLATPADFYPGYVATYIDRDVRAELGVKKIDSFNRFLTLAALRIGEVMNVSHLADEADVDSATIRNWLSILNASFIAFQLQPYYRNYGKRLVKSAKLYFYDTGLAANLLGIESADQLFASQCRGALFENAVVLEIVKQYQAQGKEPKLYYWRDSGQKEVDLIIERGGNPYFVIEIKSSATYRPKYFETLDDIAEAMGVPTERRFVVYGGEETIPTRHGTVIGLRDIGRLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVM9</accession>
    <name>B8DVM9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">IclR-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_0228</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268993.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0228"/>
    <dbReference type="EnsemblBacteria" id="ACL28530">
        <property type="protein sequence ID" value="ACL28530"/>
        <property type="gene ID" value="BLA_0228"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0228"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.240"/>
    <dbReference type="HOGENOM" id="CLU_062618_4_1_11"/>
    <dbReference type="OMA" id="EPDRLHR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="4">
        <location>
            <begin position="38"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="5">
        <location>
            <begin position="98"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL28530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="272" mass="28706" checksum="080ADB786B72E29C" modified="2009-03-03" version="1">MTSDTLAAKSAPSAETSTNNPSNHNDVPADDNEIHSGVGVLDKTVKILDALESGPATLGQLVAATHLARPTAHRLAIALERHRFVVRDQHGRFVLGSRFTELAAAAGEDRLLAAAGPILQTLLDRTGESAQIYRRQGEQRVCIAAVERASGLRDSIPVGAMLSMEAGSAAQILLAWEDTELLHQGLRHAKFSAAKLATVRKRGWADSINERDEGVCSISAPIRNASGQVIAAISISGPSGRMGSNPGHRFAPLVMGAGKYLSDALIKASISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVP1</accession>
    <name>B8DVP1_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619675.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0240"/>
    <dbReference type="EnsemblBacteria" id="ACL28542">
        <property type="protein sequence ID" value="ACL28542"/>
        <property type="gene ID" value="BLA_0240"/>
    </dbReference>
    <dbReference type="GeneID" id="66532616"/>
    <dbReference type="KEGG" id="bla:BLA_0240"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.255"/>
    <dbReference type="HOGENOM" id="CLU_097434_0_0_11"/>
    <dbReference type="OMA" id="RWPKLHE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="205" mass="23498" checksum="D323A28545AD0BF8" modified="2009-03-03" version="1">MPRPRRDPEVLPAQQRLENAFWALLRERPYGKITVTDIVREAGVNRNSFYYHFSGLPELADATIMHAVESIPIMDHATTAENLWQEWQRTCIVAFNDPQMRKQFDHLALLAGPHSTIELTEALRDFIRLTLLGNFDLDYDRIDLSTRILLDFTVGGIVGVLRDWPNIEHRLSPNDLTNPDIATVAANLRTALDSSEQRRPVQSLR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVQ3</accession>
    <name>TRMD_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine-N(1)-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trmD</name>
        <name type="ordered locus">BLA_0252</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates guanosine-37 in various tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA methyltransferase TrmD family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268357.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DVQ3"/>
    <dbReference type="SMR" id="B8DVQ3"/>
    <dbReference type="STRING" id="442563.BLA_0252"/>
    <dbReference type="EnsemblBacteria" id="ACL28554">
        <property type="protein sequence ID" value="ACL28554"/>
        <property type="gene ID" value="BLA_0252"/>
    </dbReference>
    <dbReference type="GeneID" id="66532627"/>
    <dbReference type="KEGG" id="bla:BLA_0252"/>
    <dbReference type="HOGENOM" id="CLU_047363_0_0_11"/>
    <dbReference type="OMA" id="ILCGHYK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18080">
        <property type="entry name" value="TrmD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00605">
        <property type="entry name" value="TrmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002649">
        <property type="entry name" value="tRNA_m1G_MeTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023148">
        <property type="entry name" value="tRNA_m1G_MeTrfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417">
        <property type="entry name" value="PTHR46417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000386">
        <property type="entry name" value="tRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00088">
        <property type="entry name" value="trmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_1000147073" description="tRNA (guanine-N(1)-)-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="149"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00605"/>
        </source>
    </evidence>
    <sequence length="275" mass="30454" checksum="8F502DBA5EEFFE73" modified="2009-03-03" version="1">MDIDIVSVFPEYFDVLNLSLLGKAQERGLLAVRSHNLRQWTHDVHQSVDDTPVGGGAGMVMKPEVWAECLDELLGIPADAPANAHAAPAADSPVLIFPNPSAPLFTQQDATALSHAEHLVFGCGRYEGYDARIPQYYRERGVDVREYSIGDYVLNGGEVAVSVMLEAITRLLPGFMGNADSIVEESYTGENALLEHNQYTKPASWRGIDVPPVLISGDHGRVNRFRRDEALEKTSRLRPDLIARLDCHALDKQDRKTLMSLGWEVSGEHPRKLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVR9</accession>
    <name>B8DVR9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0268"/>
    <dbReference type="EnsemblBacteria" id="ACL28570">
        <property type="protein sequence ID" value="ACL28570"/>
        <property type="gene ID" value="BLA_0268"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0268"/>
    <dbReference type="HOGENOM" id="CLU_068212_1_0_11"/>
    <dbReference type="OMA" id="AGEQMPH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="176" mass="19618" checksum="62DCD9D282368024" modified="2009-03-03" version="1">MYDIIDSLEEMITSAKGSMFSPSSVKIDRDDFLDKLEDLKTKLPVQLERASALMREAEGRLANANSQANVIISTAQARAANIIRDANERADYLASQEKVTEIARQKAKTMIDKAQAASDRLTSGADQYCIKIMNELHSQLGKMTRDVEGGLNVLEEREAKAREELPHAEESDYPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVT5</accession>
    <name>B8DVT5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type antimicrobial peptide transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619686.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0284"/>
    <dbReference type="EnsemblBacteria" id="ACL28586">
        <property type="protein sequence ID" value="ACL28586"/>
        <property type="gene ID" value="BLA_0284"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0284"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.302"/>
    <dbReference type="HOGENOM" id="CLU_019122_1_1_11"/>
    <dbReference type="OMA" id="DQAGEYR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="474" mass="50220" checksum="7AEBE75BCFD96D6E" modified="2009-03-03" version="1">MNTFALWRLFHRHMFHHDDEPDAPRDHTGLLAVIAFAAATAIFLTVLGGLHGFIWRASPDHTVGCFFNDSACSTHANVSVNGEFYVVLAMFACVLLVVPFTTLAGSAARLAATRRDERLAVLRLAGATTSQVVRLIALEAVGQAVIGSVLGIAGYFAVMPLIMMLHFENHTFDFEQLWVGPWALIGTVVGVAALALVSALLTLRKVAITPLGVTARQGAAMPGKWRVALFVVALVFGFAMLNNMNLVAGAGVAVAYGVVFAIIGGCFMLLNVIGSWVIAAVAKSRAHRPKSAATMIAMRRILDNPKRAWRNVSGIALAVFIAGITAVCGALGTASGDADAETLMMMHDISLGGTLTLVFAAVLAAVSSGIMQSASVFDQADEYHMLMLEGTDALTLRKARFSEVLTPLNTVIVISAGCSLLLMLPLVGSMLSNPAVLLRCLFGIVLCYALVTVGAVSANHTATRLDSISRRRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVV3</accession>
    <name>B8DVV3_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">fas</name>
        <name evidence="11" type="ordered locus">BLA_0302</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268448.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0302"/>
    <dbReference type="EnsemblBacteria" id="ACL28604">
        <property type="protein sequence ID" value="ACL28604"/>
        <property type="gene ID" value="BLA_0302"/>
    </dbReference>
    <dbReference type="GeneID" id="66532680"/>
    <dbReference type="KEGG" id="bla:BLA_0302"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.323"/>
    <dbReference type="HOGENOM" id="CLU_000114_7_0_11"/>
    <dbReference type="OMA" id="APLVHGM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013565">
        <property type="entry name" value="Fas1/AflB-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08354">
        <property type="entry name" value="DUF1729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="10">
        <location>
            <begin position="1343"/>
            <end position="1734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL28604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="3105" mass="332099" checksum="D2B015FA4B7DDA26" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVZ8</accession>
    <name>B8DVZ8_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">fdxC</name>
        <name evidence="10" type="ordered locus">BLA_0347</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="7">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268544.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0347"/>
    <dbReference type="EnsemblBacteria" id="ACL28649">
        <property type="protein sequence ID" value="ACL28649"/>
        <property type="gene ID" value="BLA_0347"/>
    </dbReference>
    <dbReference type="GeneID" id="66532729"/>
    <dbReference type="KEGG" id="bla:BLA_0347"/>
    <dbReference type="HOGENOM" id="CLU_139698_0_3_11"/>
    <dbReference type="OMA" id="DRMLYIH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000813">
        <property type="entry name" value="7Fe_ferredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00354">
        <property type="entry name" value="7FE8SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL28649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="107" mass="11630" checksum="DA8264FCE45B6895" modified="2009-03-03" version="1">MAYVIAQPCVDVKDKACVDECPVDCIYEGKRSLYINPNECVDCGACEPVCPTEAIFYEDDLPPEWEWYKDAAVEFFAEVGDLGGAQAAGPIGKDPQRVADLPPQNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW08</accession>
    <name>B8DW08_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable repressor in the Rok (NagC/XylR) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268559.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0357"/>
    <dbReference type="EnsemblBacteria" id="ACL28659">
        <property type="protein sequence ID" value="ACL28659"/>
        <property type="gene ID" value="BLA_0357"/>
    </dbReference>
    <dbReference type="GeneID" id="66532740"/>
    <dbReference type="KEGG" id="bla:BLA_0357"/>
    <dbReference type="HOGENOM" id="CLU_036604_13_3_11"/>
    <dbReference type="OMA" id="CYCGQKG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="363" mass="39745" checksum="DA349C4F5515DBF3" modified="2009-03-03" version="1">MESTTVKRHNRELILRELFAAPSMTKRQIADATRLSMPTITENLRELAADGLIVPAEARASTGGRKAQTWQFNARHRTAIGVALRPTEVVCMAVDLRGNVIAEHKVTMARRNDNAYYERAAHTISTFAQSLPSPIGVCFALPSSAARHCICVAEDWNAATESYQGISRILTLPCSRIARNVAYATVELHNHPLLRNAVCLYLGEYINSAIVMDGVAREGNLEHMQLDASGDICRCGSRGCLEVLCSSRQLTEEGESLPGFFGVLEQGERNHHVRMDRWLGSLAHAVNNIRTFVPADVILCGPIADYLDDSEIAQLERLTTCAEHVNPSARNPQVMRGCCVEYQDAVGAAQSLIPASHDGIPSD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW30</accession>
    <name>RS5_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsE</name>
        <name type="ordered locus">BLA_0379</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text>The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014482661.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DW30"/>
    <dbReference type="SMR" id="B8DW30"/>
    <dbReference type="STRING" id="442563.BLA_0379"/>
    <dbReference type="EnsemblBacteria" id="ACL28681">
        <property type="protein sequence ID" value="ACL28681"/>
        <property type="gene ID" value="BLA_0379"/>
    </dbReference>
    <dbReference type="GeneID" id="66532762"/>
    <dbReference type="KEGG" id="bla:BLA_0379"/>
    <dbReference type="HOGENOM" id="CLU_065898_1_1_11"/>
    <dbReference type="OMA" id="KRGCGSW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000165442" description="30S ribosomal protein S5">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="S5 DRBM" evidence="1">
        <location>
            <begin position="57"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="243" mass="25949" checksum="C82CA42E8A882431" modified="2009-03-03" version="1">MSDNEKETQVAEETQNTQATAESSNNDERRGRRNNRGGEGRRGDRRGRREDNHENEMLDRVVTINRVSKTHKGGRTFSFAALVVVGDGNGTVGVGYGKSREVPAAIAKGQLDAKKHLFNVPRIRGTVTHPVTGHDHAGTVMLRPAAPGTGVIAGSAVRAVMECAGITDILTKSMGSATAVNVVRATVDALKQLEEPEEIAARRGLSVQEVAPDQLLRERAAGIAEARKAREEAKAEAAAKDGE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW43</accession>
    <name>IF2_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">infB</name>
        <name type="ordered locus">BLA_0392</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268627.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DW43"/>
    <dbReference type="SMR" id="B8DW43"/>
    <dbReference type="STRING" id="442563.BLA_0392"/>
    <dbReference type="PRIDE" id="B8DW43"/>
    <dbReference type="EnsemblBacteria" id="ACL28694">
        <property type="protein sequence ID" value="ACL28694"/>
        <property type="gene ID" value="BLA_0392"/>
    </dbReference>
    <dbReference type="GeneID" id="66532776"/>
    <dbReference type="KEGG" id="bla:BLA_0392"/>
    <dbReference type="HOGENOM" id="CLU_006301_9_3_11"/>
    <dbReference type="OMA" id="QVRPEMI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000118750" description="Translation initiation factor IF-2">
        <location>
            <begin position="1"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="437"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="1">
        <location>
            <begin position="446"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="1">
        <location>
            <begin position="471"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="1">
        <location>
            <begin position="496"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="1">
        <location>
            <begin position="550"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="1">
        <location>
            <begin position="586"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="446"/>
            <end position="453"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="496"/>
            <end position="500"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="550"/>
            <end position="553"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="944" mass="100016" checksum="2DA00BCD8AF1DA9A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW52</accession>
    <name>SYS_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Seryl-tRNA synthetase</fullName>
            <shortName evidence="1">SerRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">serS</name>
        <name type="ordered locus">BLA_0401</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268644.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DW52"/>
    <dbReference type="SMR" id="B8DW52"/>
    <dbReference type="STRING" id="442563.BLA_0401"/>
    <dbReference type="EnsemblBacteria" id="ACL28703">
        <property type="protein sequence ID" value="ACL28703"/>
        <property type="gene ID" value="BLA_0401"/>
    </dbReference>
    <dbReference type="GeneID" id="66532785"/>
    <dbReference type="KEGG" id="bla:BLA_0401"/>
    <dbReference type="HOGENOM" id="CLU_023797_0_1_11"/>
    <dbReference type="OMA" id="SPCFRRE"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00176">
        <property type="entry name" value="Ser_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="PTHR11778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000123871" description="Serine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="231"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="262"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="349"/>
            <end position="352"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00176"/>
        </source>
    </evidence>
    <sequence length="428" mass="47946" checksum="CD5E0E86477AD95C" modified="2009-03-03" version="1">MLDIQFIREHPEVVKESQRKRGESVELVDEVLRADEERRSSLKQFEEARARQKEIGKQVAKAAPDEKAKLIAQTKELSEQVASFKASADTADEQYTTAMWQLSNIVEPQAPEGGEDDYVVMRKVGQIRDFAAEGFEPKDHLTLGEEVAGIDMKRGVKVSGSRFYFLRGDVARLQIAMLTMAVDQAQEHGFILAITPTLVRPEVMRGTGFLNSHADEIYRLREPDDDYLVGTSEVALAGMHENEILDLSDGPLRYCGWSSCYRREAGAAGKDTSGIIRVHQFDKVEMFVYAKPENSDAEHQKLLAMEEEMLAKVEVPYRVIDTAAGDLGSSAARKFDCEAWVPTQGRYRELTSTSNCTQYQARRLNIRERVADGGTSPVATLNGTLATTRWLVAILENHQQADGSIEIPKAMRPYMGGKEVIEPRKWEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW76</accession>
    <name>B8DW76_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">manA</name>
        <name evidence="7" type="ordered locus">BLA_0426</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268703.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0426"/>
    <dbReference type="EnsemblBacteria" id="ACL28727">
        <property type="protein sequence ID" value="ACL28727"/>
        <property type="gene ID" value="BLA_0426"/>
    </dbReference>
    <dbReference type="GeneID" id="66532811"/>
    <dbReference type="KEGG" id="bla:BLA_0426"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.455"/>
    <dbReference type="HOGENOM" id="CLU_026967_1_1_11"/>
    <dbReference type="OMA" id="DIGLFCG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="PTHR10309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL28727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="456" mass="50406" checksum="5E0708A764772C40" modified="2009-03-03" version="1">MYAIRPVPKHYAWGSHRTLQHVFHLDEHETQQPLAEMWFSGHAQSPSPIMVDGVEQPLTSMIERNPIDMVGRRGSEEFGPVLPYLFKLICATEPLSLQVHPVAFQARAGFNEENRAGIPLNAPERSFKDINAKSEMVVALEPFLAAVGFSTRTFALRNLELLRLPVAQRMVEALNSTATQSAGESFVMADEMMPIASAVWSPARKRLFRAFHAAITAQETDPQELLDDLQHARSLTEHTRNDLAFDFAIRAAKAFPGDTSSLALLMMNPVRLEEGQSVFLPTGTPHAYIYGTAAEIMTNSDNVLRAGLTVKHKDIVNLLQCLDCRTSTPVDPSNSQIATMLMRDLAFYKPNVSEYMLAYGQVDVQHEPWPVINALAKRYDSLVRQISGHTPFPHSGPRVVVCTQGSVQVISEADSRVLHQGDAVFVPASDGWAHVEAVIDGEGEPQGKYLVASTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWA4</accession>
    <name>B8DWA4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Possible alpha beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268770.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0456"/>
    <dbReference type="EnsemblBacteria" id="ACL28755">
        <property type="protein sequence ID" value="ACL28755"/>
        <property type="gene ID" value="BLA_0456"/>
    </dbReference>
    <dbReference type="GeneID" id="66532839"/>
    <dbReference type="KEGG" id="bla:BLA_0456"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.485"/>
    <dbReference type="HOGENOM" id="CLU_045011_9_1_11"/>
    <dbReference type="OMA" id="WIRETHG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="202" mass="23177" checksum="7F45B3B1C9205766" modified="2009-03-03" version="1">MPITDVVFDYCGVLLDWRPELTMEGKVDTSTMRRLLDHADPYGFWHYDLMSDLGWSEEQVLRDFARHHPHDVALNHAMQLYFANYTRAFAGMVDGMPELLRTLHERGYRLWGLTNFSTPFVTLAHREFPALRLLLDTVVSSEVRCAKPDARIYEIAMERFGIDPAHAMFFDDKYENAKAASESGMHGVQFLSADQAMQAILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWB7</accession>
    <name>B8DWB7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding protein of ABC transporter system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_0469</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268790.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0469"/>
    <dbReference type="EnsemblBacteria" id="ACL28768">
        <property type="protein sequence ID" value="ACL28768"/>
        <property type="gene ID" value="BLA_0469"/>
    </dbReference>
    <dbReference type="GeneID" id="66532854"/>
    <dbReference type="KEGG" id="bla:BLA_0469"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.498"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="IMCAFLV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="23"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="290" mass="31180" checksum="C325EDA0A9E777E8" modified="2009-03-03" version="1">MTQIMQQPIAAPGPVPADPSMAVSIRGLYRRYDDKVAVNGLSLDIPTGSFYGLVGPNGAGKTTTINMMTGMLKPDAGMVLVLGKDVWHDVNAVKREIGLMPQPDQIFDRLTGRQLLVYSGMLRSMPRAEALERSNDLMHAFDLLDAADKPVFDYSAGMTKKICLATAMIHSPRVLVLDEPFEAVDPVSSSNIRDILSAYVSTGGTVIISSHVMSMVERMCTHVAVINKGQVVAAGTVDQVAGGEDLDERFLQLVGGRHDTMHLDWLNGGVHAADEAVSVPQDDHQNGGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWD2</accession>
    <name>B8DWD2_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">rpmE</name>
        <name evidence="8" type="ordered locus">BLA_0484</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269057.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0484"/>
    <dbReference type="EnsemblBacteria" id="ACL28783">
        <property type="protein sequence ID" value="ACL28783"/>
        <property type="gene ID" value="BLA_0484"/>
    </dbReference>
    <dbReference type="GeneID" id="66532870"/>
    <dbReference type="KEGG" id="bla:BLA_0484"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.513"/>
    <dbReference type="HOGENOM" id="CLU_114306_4_3_11"/>
    <dbReference type="OMA" id="YHEITVV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00501">
        <property type="entry name" value="Ribosomal_L31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027491">
        <property type="entry name" value="Ribosomal_L31_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="69" mass="7795" checksum="0391D8DA661BC591" modified="2009-03-03" version="1">MQQGIHPDYHKVTVTCSCGNTFETRSTAKGDHMTVDVCSKCHPFYTGKQKILDTGGRVARFEKRYGKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWE1</accession>
    <name>B8DWE1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Drug resistance transporter, EmrB/QacA subfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BLA_0493</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0493"/>
    <dbReference type="EnsemblBacteria" id="ACL28792">
        <property type="protein sequence ID" value="ACL28792"/>
        <property type="gene ID" value="BLA_0493"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0493"/>
    <dbReference type="HOGENOM" id="CLU_587505_0_0_11"/>
    <dbReference type="OMA" id="CAMFMEN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="18"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="433"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="465" mass="50656" checksum="2F26440A36AF8F2E" modified="2009-03-03" version="1">MITAKDGQQHSWKSVKLLIATLIVSTLGDGFCGVMMAVALPNISETYHVSIATANWVTVGYAIVAATAVMTAATVLARIGLKKLFFWSRVLLIVSSLIGLFSLNFPMMLTSRLIQAVGSGLMFPTINTVIIRVVPAKISGRVVSLNSAIIGLGIAVAPLLSGVFLTYVSLTSMYVVPLAVGIISILMGAKFMFDVEPRKQHPIDVLSIVLSFVGLAALMMGFSELTHRPLFAVPMLIAGVAVLVWFAVRQFHLDVPLLDLHPMKHLYVSLGVLMYMAGAMGQQAVLLLLPLYLERACDYTPFVAGCFLLIMTLFYSGSVIVGGKTVDRSGMWPVVSSGFLLMVIGLFATFFAAPPRSRGSWCSSDPLWLSATRSSTCPTRMWCLRRCPTIRCPTRARSSRPATRSRVRSGQRCSSACFPPMYSGRPRKASTAMPHTRTASSIRSSSPRSSRWPCCLCRYGIHARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWE4</accession>
    <name>B8DWE4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28795">
        <property type="protein sequence ID" value="ACL28795"/>
        <property type="gene ID" value="BLA_0496"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0496"/>
    <dbReference type="HOGENOM" id="CLU_3058957_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="53" mass="6024" checksum="9166457F82C52EE6" modified="2009-03-03" version="1">MFALAIAVAIVVRRRAKTPAWSACTLSMYRATMFIVRNKTMRQPGSLPAHRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWH2</accession>
    <name>B8DWH2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218235.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0524"/>
    <dbReference type="EnsemblBacteria" id="ACL28823">
        <property type="protein sequence ID" value="ACL28823"/>
        <property type="gene ID" value="BLA_0524"/>
    </dbReference>
    <dbReference type="GeneID" id="66533653"/>
    <dbReference type="KEGG" id="bla:BLA_0524"/>
    <dbReference type="HOGENOM" id="CLU_052333_1_1_11"/>
    <dbReference type="OMA" id="AWFIEPY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="117"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="341" mass="36824" checksum="765D463ECBC338DD" modified="2009-03-03" version="1">MAMMRKHRVLGAIAGLLALASLCSCALRLLPVDLQTLPYVSVVLAATPWFAIVSVVSLVLALISTRWVTAIVAGVCLAIQVCWQLPFYHNGTPLSGSALSSQSLPRADTADAVARLMTCNVYKGHADAAAIVNAVRDNHVEVLALQETTPDFLKRLEEAGISQLLPYSQTSSADGYFGNALFSALPFENPSQTDVDSIASYMPGGTVGFDNGAIPVRFVSVHTQSPTEGRFEKWSRSIAELKQLNEHPDTDYILMGDFNSTWDHAVFRDMLGTRFQDAAEVSGHGLVFTWPADRKYLPAFAGIDHIVTSKDVTIGQVNSLTIPGSDHRALLATVDVSGLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWH8</accession>
    <name>B8DWH8_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">def</name>
        <name evidence="3" type="ordered locus">BLA_0530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218243.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0530"/>
    <dbReference type="EnsemblBacteria" id="ACL28829">
        <property type="protein sequence ID" value="ACL28829"/>
        <property type="gene ID" value="BLA_0530"/>
    </dbReference>
    <dbReference type="GeneID" id="66533660"/>
    <dbReference type="KEGG" id="bla:BLA_0530"/>
    <dbReference type="HOGENOM" id="CLU_061901_5_2_11"/>
    <dbReference type="OMA" id="ILYPMRI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="217" mass="24509" checksum="74A49E23CB6A0D2B" modified="2009-03-03" version="1">MFGKKNHVDIELNADVERLLKSAKEGVLPIVEAGEPVLREQCVRYDGQLSKHTLHKLIETMHKTMLDAPGVGLAGPQIGLNLAIAVVEDHANGDDDGDPREIAEFPFHAIINPVYRPAGEETRSFYEGCLSFDGYQAVRKRYLDIIAHWHDEDGKEHEEHLHGWPARIFQHETDHLSGELYIDQAEIRSLTTVENLEDFWAQDPVPTQAAKELGFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWK2</accession>
    <name>B8DWK2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sortase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0554</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="C60.007"/>
    <dbReference type="EnsemblBacteria" id="ACL28853">
        <property type="protein sequence ID" value="ACL28853"/>
        <property type="gene ID" value="BLA_0554"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0554"/>
    <dbReference type="HOGENOM" id="CLU_045680_1_2_11"/>
    <dbReference type="OMA" id="ILDPWID"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05827">
        <property type="entry name" value="Sortase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042002">
        <property type="entry name" value="Sortase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01076">
        <property type="entry name" value="sortase_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870845" evidence="3">
        <location>
            <begin position="25"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="280" mass="30647" checksum="939EC03ED0AFC744" modified="2009-03-03" version="1">MIISMVIMLLVGVGLIVYPTVADAWNRHVSSRAIAGYSEQVANTPKEDREAQIKKAREYNENLLGQGNARFLPNGEEKKVYNSILDVSGTGIMGYIAIPAIHAKLPIYHGTDETVLQIAAGHYEGSSFPIGGESTHAVITGHTGLPSAQLFTGIDGMKKGDKFSITVYDDVLTYEVEERQVVLPTNVKPLAIQEGRDLVSLVTCTPYGVNSHRLILTAHRIPTPENKKEVEVNPERAIMSDIAITAFVIVGVAVCMATIVITQRRRRKTHAHGSHLRSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWK3</accession>
    <name>B8DWK3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Galactokinase</fullName>
            <ecNumber evidence="10">2.7.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">galK</name>
        <name evidence="10" type="ordered locus">BLA_0555</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.6" evidence="10"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218283.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0555"/>
    <dbReference type="EnsemblBacteria" id="ACL28854">
        <property type="protein sequence ID" value="ACL28854"/>
        <property type="gene ID" value="BLA_0555"/>
    </dbReference>
    <dbReference type="GeneID" id="66533685"/>
    <dbReference type="KEGG" id="bla:BLA_0555"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.585"/>
    <dbReference type="HOGENOM" id="CLU_017814_2_1_11"/>
    <dbReference type="OMA" id="PVCYNLR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalKase_gal_bdg" evidence="9">
        <location>
            <begin position="21"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="7">
        <location>
            <begin position="128"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="8">
        <location>
            <begin position="315"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL28854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="416" mass="43862" checksum="CE18192623A6CDC7" modified="2009-03-03" version="1">MTSVEFIEPMSDAEGAARAAELFKQAYGKEPAGVWAAPGRVNLIGEHTDYNAGLCLPIALPHRTYIALSPRDDTSVRVVSDLASDVIAEADLDGLEAGGVDGWAAYPVGVAWALRNAGFDGVQGFDAAFSSCVPLGSGLSSSAAMTCSTALALDDVYSQGFGDTDEGRVTLINAAIASENDMAGASTGGLDQNASMRCTPDHAIRLDCRPGLSAVDSVQQEVFDLEGHGLELLVLDTRAPHQLNDGQYAQRRATCEEAARILGVANLREVADLVNAQADPAAALDGVLDRLDDETMRKRVRHVVTEIGRVDDFVRAFAEGDMQTAGELFNASHDSLRDDYEVTVPELDVAVDVARDEGALGARMTGGGFGGSIIALVNAGESQRIAQAICDEFERRGFVLPRALPAQASASAHRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWK8</accession>
    <name>B8DWK8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable NADH-dependent flavin oxidoreductase YqjM</fullName>
            <ecNumber evidence="2">1.6.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">baiC</name>
        <name evidence="2" type="ordered locus">BLA_0560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.6.99.1" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218290.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0560"/>
    <dbReference type="EnsemblBacteria" id="ACL28859">
        <property type="protein sequence ID" value="ACL28859"/>
        <property type="gene ID" value="BLA_0560"/>
    </dbReference>
    <dbReference type="GeneID" id="66533690"/>
    <dbReference type="KEGG" id="bla:BLA_0560"/>
    <dbReference type="HOGENOM" id="CLU_012153_2_0_11"/>
    <dbReference type="OMA" id="NQRRDQY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018548">
        <property type="term" value="F:pentaerythritol trinitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="PTHR43303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="17"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="376" mass="41377" checksum="44F746AE534C713F" modified="2009-03-03" version="1">MGKSKDSKKVKAQQPTLFTPFTLRGITARNRIWMPPMDTYSAFALDGRPGNFHYQHYVSRAMGGFGLIIVEATAVTPDGRISPCDLGLWEDSQIDSYRWIAQGMKDAGAVPAIQLNHAGRKGSTSCFAIRTDSGYVSPELGGWQTVAPSELPFGDLPAPRQLTVDEIHDIVNRFRDAAWRAMEAGFEVIEIHAAHGYLLSEFLDPLVNDRDDEYGGSLENRIRIVIEVADAIRSVIRGDMPLFARISATDWAEGGWDLDQSIVLAKALKEHGVDLVDVSTGGILPNVTIPTKPGYQVPFSEQIRKKADVPVTAVGLITKPKQAARILAKGEADAVEIGRAALREPYWPLRAGFKLGEPTDLLPYPPQYVRGAWRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWM3</accession>
    <name>B8DWM3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218309.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0577"/>
    <dbReference type="EnsemblBacteria" id="ACL28874">
        <property type="protein sequence ID" value="ACL28874"/>
        <property type="gene ID" value="BLA_0577"/>
    </dbReference>
    <dbReference type="GeneID" id="66533705"/>
    <dbReference type="KEGG" id="bla:BLA_0577"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.608"/>
    <dbReference type="HOGENOM" id="CLU_138371_0_0_11"/>
    <dbReference type="OMA" id="TAYPEDK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="149" mass="16520" checksum="431B608C4E7B71CD" modified="2009-03-03" version="1">MSSLQGFEVVSPNTASGRSVLTVTKNYARLNKNAVLELGRPEFIEFFINPTTKQFAFKACEESNPNAIPFFIPGKTTASVTLNQQFVLDAMGPYFEFPEVEDDQEAYAQIKGTLLNSEDMLVFNAAKAEQGVMKKRGRKKGQKVKVSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWP2</accession>
    <name>B8DWP2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218331.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28893">
        <property type="protein sequence ID" value="ACL28893"/>
        <property type="gene ID" value="BLA_0596"/>
    </dbReference>
    <dbReference type="GeneID" id="66533726"/>
    <dbReference type="KEGG" id="bla:BLA_0596"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.628"/>
    <dbReference type="HOGENOM" id="CLU_2128605_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="113" mass="11931" checksum="0127A0A04429B159" modified="2009-03-03" version="1">MTTINDSPITNDSDTELEAFEQRVNEMLSTGELDSALSITDENGVAQVLPMLDTEPIAHLLDGIEELGGSANVFVRTAEGTAILTVNEYSPEDAALDTAESEADAEADAQSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWQ0</accession>
    <name>B8DWQ0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218343.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28901">
        <property type="protein sequence ID" value="ACL28901"/>
        <property type="gene ID" value="BLA_0604"/>
    </dbReference>
    <dbReference type="GeneID" id="66533737"/>
    <dbReference type="KEGG" id="bla:BLA_0604"/>
    <dbReference type="HOGENOM" id="CLU_060501_0_0_11"/>
    <dbReference type="OMA" id="ININIVM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="377" mass="43085" checksum="4D3378B0D4A25266" modified="2009-03-03" version="1">MIQAVSYFILLSISFFKRKSYILYFVCIVFLWLIASFTTGNADEQIYQSRYDEYQLWEDNTEYLYMALIKTCNALGLTYQAFKCVSAFIVLTLISCTILRFAACPILTLLLYAVYPFPIDVAQMRNCLATSVFIFGMGFLLDDVQNGDNQGRFLTKNDILYCLCIFIATMVHTAAFFWIIILVAKKLNTKWAAIFTFVFCLLFSAIMTPRFISGLSGLFGSNDRINAYTTAAYDLTRDLHLPLALLRVAIFFITSLAVLLITNLSSMKMTGVQKKEYIFYFKITILTLCILPITINYTPEIYRMQTGLSLIFYMIILNIISGETINSTNDAILRFIIPLLLLVFGVVNAFLLYIFGDNLETVFIPIFENNTFFNSIV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWS0</accession>
    <name>NUCS_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease NucS</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nucS</name>
        <name type="ordered locus">BLA_0628</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NucS endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219182.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DWS0"/>
    <dbReference type="SMR" id="B8DWS0"/>
    <dbReference type="STRING" id="442563.BLA_0628"/>
    <dbReference type="EnsemblBacteria" id="ACL28921">
        <property type="protein sequence ID" value="ACL28921"/>
        <property type="gene ID" value="BLA_0628"/>
    </dbReference>
    <dbReference type="GeneID" id="66533759"/>
    <dbReference type="KEGG" id="bla:BLA_0628"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.659"/>
    <dbReference type="HOGENOM" id="CLU_069350_0_0_11"/>
    <dbReference type="OMA" id="RCSVDYA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00722">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002793">
        <property type="entry name" value="Endonuclease_NucS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38814">
        <property type="entry name" value="PTHR38814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01939">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000198194" description="Endonuclease NucS">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00722"/>
        </source>
    </evidence>
    <sequence length="234" mass="25928" checksum="05660C2D11891476" modified="2009-03-03" version="1">MRIIVADCCAEYTGRLSASLPLAKRVLLIKADNSLLIFSEIGSYKPLNWMLSPCTIKDITPQDADDDPATPTPEKIIRVQSTKTNDVLEVTLQHIYSDETHDLGTDPGLRKDGVEDHLQRYLAEQIERIGEGAKLVRREYPTAIGPVDIMAIDADGTHVAIEIKRHGGIDGVEQLTRYCELLNRDPLLAPVRGIFAAQTITPQAQVLAKDRGFDCLLLDYDDMKGTDDGALRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWU2</accession>
    <name>B8DWU2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxalyl-CoA decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">oxc</name>
        <name evidence="7" type="ordered locus">BLA_0650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.8" evidence="7"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219148.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0650"/>
    <dbReference type="EnsemblBacteria" id="ACL28943">
        <property type="protein sequence ID" value="ACL28943"/>
        <property type="gene ID" value="BLA_0650"/>
    </dbReference>
    <dbReference type="GeneID" id="66533783"/>
    <dbReference type="KEGG" id="bla:BLA_0650"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.678"/>
    <dbReference type="HOGENOM" id="CLU_013748_3_3_11"/>
    <dbReference type="OMA" id="DIGSHYI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008949">
        <property type="term" value="F:oxalyl-CoA decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033611">
        <property type="term" value="P:oxalate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045025">
        <property type="entry name" value="HACL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017660">
        <property type="entry name" value="Oxalyl-CoA_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43710">
        <property type="entry name" value="PTHR43710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03254">
        <property type="entry name" value="oxalate_oxc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="20"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="209"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="413"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL28943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="590" mass="63360" checksum="A9A81E65D8B39BE0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWU6</accession>
    <name>B8DWU6_BIFA0</name>
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        <recommendedName>
            <fullName evidence="3">Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase</fullName>
            <shortName evidence="3">GMPMT</shortName>
            <ecNumber evidence="3">2.4.99.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">(1-&gt;4)-alpha-D-glucan:maltose-1-phosphate alpha-D-maltosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glgE</name>
        <name evidence="6" type="ordered locus">BLA_0654</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1-&gt;4)-glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate = [(1-&gt;4)-alpha-D-glucosyl](n+2) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42692"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:10183"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
            <dbReference type="EC" id="2.4.99.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. GlgE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.16" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0654"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28947">
        <property type="protein sequence ID" value="ACL28947"/>
        <property type="gene ID" value="BLA_0654"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0654"/>
    <dbReference type="HOGENOM" id="CLU_015798_0_0_11"/>
    <dbReference type="OMA" id="RPNFWPN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030979">
        <property type="term" value="P:alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02124">
        <property type="entry name" value="GlgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026585">
        <property type="entry name" value="GlgE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021828">
        <property type="entry name" value="GlgE_dom_N/S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF203">
        <property type="entry name" value="PTHR10357:SF203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11896">
        <property type="entry name" value="DUF3416"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="5">
        <location>
            <begin position="338"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Maltose 1-phosphate binding" evidence="3">
        <location>
            <begin position="660"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="521"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="550"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="522"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL28947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="801" mass="89375" checksum="F607D7DC5B3D54B3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSI9</accession>
    <name>B8DSI9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Copper-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">silP</name>
        <name evidence="5" type="ordered locus">BLA_0675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219110.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0675"/>
    <dbReference type="EnsemblBacteria" id="ACL28968">
        <property type="protein sequence ID" value="ACL28968"/>
        <property type="gene ID" value="BLA_0675"/>
    </dbReference>
    <dbReference type="GeneID" id="66533808"/>
    <dbReference type="KEGG" id="bla:BLA_0675"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.703"/>
    <dbReference type="HOGENOM" id="CLU_583514_0_0_11"/>
    <dbReference type="OMA" id="MRMLIPA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="468" mass="51199" checksum="6C7085A565FEB8CA" modified="2009-03-03" version="1">MTLNTFIAAVCVVVAIMLTIAHIRFFFGEETHKQQGELFHQPPHDEAAPVSAGDTLRTRRRDNAADLRILRKQIIVGAALTLVVVIPILIHTFAPHCPLGPLVDPWWQAVLITPVMFYSGYPVHVDGWSSLADRRPNMNTLASIGTIAAYAYGLLICFAGDLFPAGMRMSYFAIVGIVITLVLLARLVSDLYLPQQPAFPLQLWVDRFSFVFVPVVIMIALWTFVAWLLFGRQPALPMALLTAISVLIIACPCALGWAATLAAVFANENAGRHGLQIHSLGSLQIARHLTDVLFAQEAASRCQEDIRRLQQAGVSTSVIDADAVDDVLATVDSMRKLAVSLGQRPVVAFVGDGPTDERIRHAVDITLEVGEAKEGEAHGHADVIVDSRSTMAVSDLRNLSHAMMANIRENLVWTFAFNIIGIPIAAGVLYPFTSWLLDPSFAAIAMILSSLCVLVNSLRMRHYNPERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSK9</accession>
    <name>B8DSK9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tetracycline resistant protein Tet38</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BLA_0695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0695"/>
    <dbReference type="EnsemblBacteria" id="ACL28988">
        <property type="protein sequence ID" value="ACL28988"/>
        <property type="gene ID" value="BLA_0695"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0695"/>
    <dbReference type="HOGENOM" id="CLU_000960_3_2_11"/>
    <dbReference type="OMA" id="LMYSPIV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="18"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL28988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="483" mass="52302" checksum="15CB156B93A871A3" modified="2009-03-03" version="1">MQEEPVDLEQQNKMAVRALILLLITFILGTLCLQGFNLVFTNIGSDVGAPEQAALITSLPSIVLGIVCFIYGSLGDFVSLKKLIVFGLVTLFVGSLFGFIANFFFTKNLWTVIIARILQTAGEQVSGSVYLVIATKYLKKELKVIFFGLFTAGYQVSAAIGVFAAGLLTSIAWQYLFLIPAVTIVFLPFLLHLLPNRRGGSQHVDWLGFTIFGLASAFLSLFFSYNSWWMLAVCVVLFVLFGVYINKASDPFITPAFFKNTRWLAAIMLIVLFYFTNYCVSPIFNTMGTTLYNMDVTQVSQYIVWAFIVAAVFGTTSGWIVGKIGRTTAIVLASLLMICGFVGSALCVNTDFGLLTLFACIFYAGCGLMYSPVVSTVLDTLPVDESGRGVGMNDLVMNVTASIGIAVFGAQLGGTALAGGSLTGATGPAAVYSNLLIIAAGVVVLGLVWFLVFHKHIYRGESAQVQKEVEQPEDVEEVLHPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSM8</accession>
    <name>B8DSM8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218729.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0714"/>
    <dbReference type="EnsemblBacteria" id="ACL29007">
        <property type="protein sequence ID" value="ACL29007"/>
        <property type="gene ID" value="BLA_0714"/>
    </dbReference>
    <dbReference type="GeneID" id="66533475"/>
    <dbReference type="KEGG" id="bla:BLA_0714"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.745"/>
    <dbReference type="HOGENOM" id="CLU_098941_0_0_11"/>
    <dbReference type="OMA" id="INIDASD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870465" evidence="1">
        <location>
            <begin position="30"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="195" mass="20894" checksum="5E3B8D242D624A3A" modified="2009-03-03" version="1">MARRTKRLAAIACAVAALALMAGCTPKGAAVGDTQNNETYEHNHNENTGARLDVAVIGSPHGGADELVMRSLATKEFKASYTGVQQYSADPQRAADFARKAVSDAVSRHPKVIVISGLTFHDDESQWNTALANARNAGIPVVLLNPADVPGDTKLFAATFVVNDRMMDAQPMGEALRSVIFDHPHEREIVVSTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSN6</accession>
    <name>B8DSN6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable permease protein of ABC-transporter for peptides</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dppB</name>
        <name evidence="7" type="ordered locus">BLA_0722</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218721.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0722"/>
    <dbReference type="EnsemblBacteria" id="ACL29015">
        <property type="protein sequence ID" value="ACL29015"/>
        <property type="gene ID" value="BLA_0722"/>
    </dbReference>
    <dbReference type="GeneID" id="66533483"/>
    <dbReference type="KEGG" id="bla:BLA_0722"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.753"/>
    <dbReference type="HOGENOM" id="CLU_036879_0_0_11"/>
    <dbReference type="OMA" id="FLMVNVM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="308" mass="33695" checksum="7F0C2A6ABE150375" modified="2009-03-03" version="1">MGKYLLRRILQMIPVVLGTTLLVYALVFALPGDPVKAMFGDKPVNEAVAAQIRSEYNLDKPFIVQYLLFLKNALSLNFGNTFAGQPVIDEISRAFPVTLKLALMAFCFEAIFGCVFGAISGLKKGKWYDSVILIVSLLLISVPTFVTGFVGQYFLGVKGHIFPVTAGADPGFFDLLLPAMVLGSVSMAYIIRLARSEISSNIAQDYVRTARAKGMSNTAVTFRHILRNSMIPVVTYLGQDLGALMGGAMITEQIFNIHGIGYLTYQSILKGEANLVVSVVTLLTLVFVICNLIVDMLYAALDPRIRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSR1</accession>
    <name>B8DSR1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methicillin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FemABX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218688.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0747"/>
    <dbReference type="EnsemblBacteria" id="ACL29040">
        <property type="protein sequence ID" value="ACL29040"/>
        <property type="gene ID" value="BLA_0747"/>
    </dbReference>
    <dbReference type="GeneID" id="66533508"/>
    <dbReference type="KEGG" id="bla:BLA_0747"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.778"/>
    <dbReference type="HOGENOM" id="CLU_050488_0_0_11"/>
    <dbReference type="OMA" id="WVAKPTE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016755">
        <property type="term" value="F:aminoacyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044038">
        <property type="term" value="P:cell wall macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038740">
        <property type="entry name" value="BioF2-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003447">
        <property type="entry name" value="FEMABX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13480">
        <property type="entry name" value="Acetyltransf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51191">
        <property type="entry name" value="FEMABX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyltransf_6" evidence="2">
        <location>
            <begin position="151"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="349" mass="39437" checksum="8F42CD072E80B65D" modified="2009-03-03" version="1">MIIIERVTPATMEEEASKHNIELPIEQTSVWADFQADINGRRPWGCLLIRRDTELVAVISLIDMETHGYHYLRSVHGPVWASKPNEELEEQMIAALADYVKRNDKRVAFLRIDTWTSKGTFPVLSTVPYNETVVLDITGDDEEILARMKKRGRRDVRKALRESPAVIADETELATRDFSDYYAVMVETAHRDGFNPAPMSDYTDMIKALGPEHCRVFAGRIDGKVVAWSIVTVHGKTGVYYYASMLTSVRREHVPDKLLYFVACALGKQGCTKLDLMGIGNDFAPSLKSLNEFKTKFAPETTQIAAGRDIPIKKAFYRMLRMMQSVRKALKPKPHGNAEKVRAKESAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSR8</accession>
    <name>B8DSR8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29047">
        <property type="protein sequence ID" value="ACL29047"/>
        <property type="gene ID" value="BLA_0754"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0754"/>
    <dbReference type="HOGENOM" id="CLU_3395297_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="34" mass="3832" checksum="B49E92BDCCF80A47" modified="2009-03-03" version="1">MSDMRDANPDSGAVCYFLPNHYSDRCPVEFGSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSX1</accession>
    <name>B8DSX1_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell wall synthesis protein Wag31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Antigen 84</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BLA_0808</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DivIVA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218602.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0808"/>
    <dbReference type="EnsemblBacteria" id="ACL29100">
        <property type="protein sequence ID" value="ACL29100"/>
        <property type="gene ID" value="BLA_0808"/>
    </dbReference>
    <dbReference type="GeneID" id="66533570"/>
    <dbReference type="KEGG" id="bla:BLA_0808"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.842"/>
    <dbReference type="HOGENOM" id="CLU_590084_0_0_11"/>
    <dbReference type="OMA" id="RNKQFTT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007793">
        <property type="entry name" value="DivIVA_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05103">
        <property type="entry name" value="DivIVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="205"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="382"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL29100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="504" mass="56132" checksum="7B6B7B39A09F12A8" modified="2009-03-03" version="1">MALLTPKDIREHTFQTVRFKEGYDVDEVDDFLDQVTETVEALGKQAVAGGQSTQALGPDVSALNTKISDLTAQVQSLQQENQSLKAAAAQGAGEQATAQIAQANQAAQAAQAQLKEAESNNQALSTQNEQLKNQIERLSAQVDQLTAQAAQNSDQPDLAKELQEITRQRDQFRADSENLRHELSAAHEQTMRAQQAEAQVKDLTKQLEESKQREEQLRDQVAKVEPNTETGSLQKIKSAAAAANSEPERATAMLTLAMQLHDQYVDKGKATAKEITEQAQRKYEELISKANDYSNRTRSEADDYNARTREAADAYSAKTRDDADSYSAKTHEDADTYMKNKHAEADQYVVDKTNEANTYADQKIAEANNYAAAKTNEADTYADSKAHEADEYAQKKQDEGNTYAQQKKSEADQYVVERHDEINAFEAEAKKRADDYSAKTRTAADDYAQQVRENLETQSKVIEGNIQGLKTFETEYRARLTEFLGQLQAQVSDTNNYKDIDKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSY7</accession>
    <name>B8DSY7_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">uppS</name>
        <name evidence="3" type="ordered locus">BLA_0824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269211.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0824"/>
    <dbReference type="EnsemblBacteria" id="ACL29116">
        <property type="protein sequence ID" value="ACL29116"/>
        <property type="gene ID" value="BLA_0824"/>
    </dbReference>
    <dbReference type="GeneID" id="66533585"/>
    <dbReference type="KEGG" id="bla:BLA_0824"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.858"/>
    <dbReference type="HOGENOM" id="CLU_038505_1_2_11"/>
    <dbReference type="OMA" id="PRTEGHK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="42"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="86"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="215"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="263" mass="30023" checksum="831090DFA500D494" modified="2009-03-03" version="1">MAFDAVDYKSLSVPAAPFSDPTIIPDFPKNKVPRHVGVIMDGNGRWAQQRGLIRTDGHQAAEPVVFDTIAGAIEAGVRYLSLYTFSTENWKRSPQEVRFLMGFSRDIIHRRVAQMDEWGVRVRWSGRRPKLWKSVIDELEVAMERTKRNKVIDVVFCINYGGRAEIADAAAAIAREVRDGRIKGDRVTEKMISEHLYNPDIPDCDLVIRTSGEQRTSNFLPWEAAYAELDFVPELFPDCGRVVLWGSIDRYIHRDRRFGGVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT59</accession>
    <name>B8DT59_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable MerR-type-transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269247.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0896"/>
    <dbReference type="EnsemblBacteria" id="ACL29188">
        <property type="protein sequence ID" value="ACL29188"/>
        <property type="gene ID" value="BLA_0896"/>
    </dbReference>
    <dbReference type="GeneID" id="66533876"/>
    <dbReference type="KEGG" id="bla:BLA_0896"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.938"/>
    <dbReference type="HOGENOM" id="CLU_060077_7_0_11"/>
    <dbReference type="OMA" id="RLYEMCA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="40"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="184" mass="20545" checksum="54D0929960AEE940" modified="2009-03-03" version="1">MTRISPARRRLYEMCATAIVAKRANLEGAAGVGFDIDLPVFSVGKVGQIAEIHPQTLRQYDRQGLVVPGRTEGGSRRYCLRDVDRLVQAQHLSQDEGINLNGVMRILELEEENRQLRHEVQELTGVTGFSVFTADMNGSITQTSRSHRARYWRGQLHAEVHALPAGESSSAQSKSMVLWHTAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT65</accession>
    <name>B8DT65_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0902"/>
    <dbReference type="EnsemblBacteria" id="ACL29194">
        <property type="protein sequence ID" value="ACL29194"/>
        <property type="gene ID" value="BLA_0902"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0902"/>
    <dbReference type="HOGENOM" id="CLU_045011_8_6_11"/>
    <dbReference type="OMA" id="EMTGCRE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="260" mass="29194" checksum="E7B3C96E5BE22BBC" modified="2009-03-03" version="1">MTHYTTVFFDLYGTLIDIHTEEDSDAAWSALRAALYQNGADYATNSQLRNEFRRQVVRANATRARTEWFEPDFLPAYRGLLEACWADDSLVHARKAAWAFRRAATTKFRLYPGVFDMLTQLRAAGLRVALVSNAQACYTRPELELTGLGDVFDEVVISSDEGVRKPSAELFRSALVRMNVEPKHVVMVGNDPRNDIDGARMANIDGIYLHTDNHTPAQCDTAVCSLEGADYAGVLAYIQRANTEDGRGREYSDTLEEKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT67</accession>
    <name>B8DT67_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative sugar ABC transport system membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_0904</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219261.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0904"/>
    <dbReference type="EnsemblBacteria" id="ACL29196">
        <property type="protein sequence ID" value="ACL29196"/>
        <property type="gene ID" value="BLA_0904"/>
    </dbReference>
    <dbReference type="GeneID" id="66533884"/>
    <dbReference type="KEGG" id="bla:BLA_0904"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.946"/>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_11"/>
    <dbReference type="OMA" id="AWLLKGY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="113"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="322" mass="36658" checksum="052777600071B0D7" modified="2009-03-03" version="1">MSNATKAQTKASEAYVEAIDKRVDSELAESHNAQRQSFWKDQKSRRILGDVLTYVLLTVLGIIWLLPIVWIFLESLNKNTAPFTDTFFPTQYSFDSYVTLFTQRNVLDFPRMFMNTFIIAVFTCIISVFFVLSVAYVMSRMRFHGRRFFMNFVLILGMFPGIMSVVAIYFILKAMGLTSSGTTILALILVYSAGTGAGFYVMKGYMDTIPTSLDEAAMLDGCTRWQVFWIIIVPICRPMIVYQAIVGFLTPWLDFVMAKVIARTQENYTASLGLWLMLDKEYINNWFGRFAAAAVLISIPIAILFIVMQRFYQESMSGSVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT77</accession>
    <name>B8DT77_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable alpha-1,4-glucosidase</fullName>
            <ecNumber evidence="2">3.2.1.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">aglA</name>
        <name evidence="2" type="ordered locus">BLA_0914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.20" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0914"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29206">
        <property type="protein sequence ID" value="ACL29206"/>
        <property type="gene ID" value="BLA_0914"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0914"/>
    <dbReference type="HOGENOM" id="CLU_006462_2_3_11"/>
    <dbReference type="OMA" id="NEANERH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032450">
        <property type="term" value="F:maltose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="18"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="514" mass="58469" checksum="C72AAF2C5A4456B0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-06-16" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT91</accession>
    <name>MIAA_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dimethylallyl diphosphate:tRNA dimethylallyltransferase</fullName>
            <shortName evidence="1">DMAPP:tRNA dimethylallyltransferase</shortName>
            <shortName evidence="1">DMATase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Isopentenyl-diphosphate:tRNA isopentenyltransferase</fullName>
            <shortName evidence="1">IPP transferase</shortName>
            <shortName evidence="1">IPPT</shortName>
            <shortName evidence="1">IPTase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">miaA</name>
        <name type="ordered locus">BLA_0928</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IPP transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217584.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DT91"/>
    <dbReference type="SMR" id="B8DT91"/>
    <dbReference type="STRING" id="442563.BLA_0928"/>
    <dbReference type="EnsemblBacteria" id="ACL29220">
        <property type="protein sequence ID" value="ACL29220"/>
        <property type="gene ID" value="BLA_0928"/>
    </dbReference>
    <dbReference type="GeneID" id="66533458"/>
    <dbReference type="KEGG" id="bla:BLA_0928"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.971"/>
    <dbReference type="HOGENOM" id="CLU_032616_0_1_11"/>
    <dbReference type="OMA" id="YAKRQYT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000377086" description="tRNA dimethylallyltransferase">
        <location>
            <begin position="1"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="21"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="1">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00185"/>
        </source>
    </evidence>
    <sequence length="344" mass="38028" checksum="C844E4DD6A9CD77F" modified="2009-03-03" version="1">MPSAGVERHDGARVISIVGPTASGKTGLGIAIARRLADRGERAEIVNADAYQMYRGMDIGTAKASDEERAAVRHHLLDVIEPSETMSVARFQQMARETIADLKSRGIRPILVGGSGLYARAAIDDISFPGTDPQIREHLEERERTEGATALFRELAVKDPQAAEHMDPRNPRRIIRALEVIEVTGKPYSATLPRYRYVIPSVQLGLDLDRADLDKRIDVRTRQMFDGGFVDEVARLRSHLGPTAARALGYQQVIDHLDGLVDLDDTMADIAQKTKRLARKQMGWFGRDPRIHWLSALNPALVDNAMAVIDHADAGDYDAIDMHAQEYVQHHLGDIRRPSGAGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2021-02-10" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTB2</accession>
    <name>B8DTB2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sugar transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BLA_0951</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GRP transporter (TC 2.A.7.5) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29241">
        <property type="protein sequence ID" value="ACL29241"/>
        <property type="gene ID" value="BLA_0951"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0951"/>
    <dbReference type="HOGENOM" id="CLU_497542_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015144">
        <property type="term" value="F:carbohydrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010651">
        <property type="entry name" value="Sugar_transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119">
        <property type="entry name" value="PTHR16119"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06800">
        <property type="entry name" value="Sugar_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="517"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL29241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="547" mass="58836" checksum="1B17A6038A7C2AB7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTD5</accession>
    <name>B8DTD5_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent Clp protease ATP-binding subunit ClpX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">clpX</name>
        <name evidence="9" type="ordered locus">BLA_0974</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the ClpX chaperone family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217641.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0974"/>
    <dbReference type="EnsemblBacteria" id="ACL29264">
        <property type="protein sequence ID" value="ACL29264"/>
        <property type="gene ID" value="BLA_0974"/>
    </dbReference>
    <dbReference type="GeneID" id="66533415"/>
    <dbReference type="KEGG" id="bla:BLA_0974"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1017"/>
    <dbReference type="HOGENOM" id="CLU_014218_8_2_11"/>
    <dbReference type="OMA" id="HYKRVQA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00175">
        <property type="entry name" value="ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046425">
        <property type="entry name" value="ClpX_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00994">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ClpX-type ZB" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="141"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL29264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="442" mass="48434" checksum="5F98171D79D0A6E0" modified="2009-03-03" version="1">MGRVVSYNDGVQRCTFCGKSEHEVHRLVAGAGVAICDECIGLCVQILSEENAKDSRLEVLKLPKPSQIRDVLDQYVIGQNDAKRTLSVAVYNHFKRAQIERHDANAHRQFEQSRLADSTRSILDPLDEVSVAKSNILLLGPTGVGKTYLAQTLAKAMQVPFIIVDATSITEAGYVGDDVEMVLSRLLQAADGDVDRARHGIVYIDEVDKIARKSGDNTSMTRDVSGEGVQQALLKILEGTLVHVPVDGAHRHKDGETVELDTSDILFICGGAFVGLDEIVSRRLGRHESGFGASWRVNPIDEHEIYRQVNADDLAEFGLLPEFIGRLPVVCTLGELTVDDLKDVLTKPTNALLKQYQKLFSVDGVTLTFTDAAVEAIASTALERGVGARGLRSIIESILEETMFELPNMDDVTEVVVNADCVTEGVPPQMVRPERRRVIHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTF6</accession>
    <name>B8DTF6_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0995"/>
    <dbReference type="EnsemblBacteria" id="ACL29285">
        <property type="protein sequence ID" value="ACL29285"/>
        <property type="gene ID" value="BLA_0995"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0995"/>
    <dbReference type="HOGENOM" id="CLU_141446_1_2_11"/>
    <dbReference type="OMA" id="MIIMPAN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="39"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="116" mass="12356" checksum="67070D377FECEC38" modified="2009-03-03" version="1">MDEPGMQMLDGVADMVSIQPEATVSRTAMRTEGGNVVLFAFDSGQELSEHTAAMPAFIQVLRGRLLVNGGDDEREVAPGDLVYLPTRLPHAVKALEPSVMMLTMITAARAADAIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTG0</accession>
    <name>B8DTG0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BLA_0999</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0324 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619901.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0999"/>
    <dbReference type="EnsemblBacteria" id="ACL29289">
        <property type="protein sequence ID" value="ACL29289"/>
        <property type="gene ID" value="BLA_0999"/>
    </dbReference>
    <dbReference type="GeneID" id="66533388"/>
    <dbReference type="KEGG" id="bla:BLA_0999"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1042"/>
    <dbReference type="HOGENOM" id="CLU_033541_0_1_11"/>
    <dbReference type="OMA" id="FGLWCAI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018383">
        <property type="entry name" value="UPF0324_pro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30106">
        <property type="entry name" value="PTHR30106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03601">
        <property type="entry name" value="Cons_hypoth698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="369" mass="39430" checksum="E38B025887FEEE5D" modified="2009-03-03" version="1">MKEFCRKWAKRIATKQMALIAIITLTATLIGMWAARFEGLKILGALIIALLIGMVVQFPIRAWYTKDDPQRAAGVKDAAGLIANKFLRFGIILLGFKLNLELLFTTGAKCLPLAALVVTVTVFVTYWICRWMGVDPLMAILVSCGTGICGAAAVMGVSGSIKVSPKRESEKENDEVTAIAIVAIMGTIFALLEIAILPLLNLTQPQEGFIAGGSLHEIAHAVAAGEGLNRPVPAGQVDAATMANIMKLSRVLMLVFVSIIVAIWWDKRHSEVTEVGGKRKVAFPWFMLGFIATAAIGTLFLQTVPASAGFINALGGNVAKIFLGMAMASLGINVNFKAIAKTGVKPLIASFIASIILVLICWGLAVLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTH8</accession>
    <name>B8DTH8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1017"/>
    <dbReference type="EnsemblBacteria" id="ACL29307">
        <property type="protein sequence ID" value="ACL29307"/>
        <property type="gene ID" value="BLA_1017"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1017"/>
    <dbReference type="HOGENOM" id="CLU_079631_2_0_11"/>
    <dbReference type="OMA" id="SWLPKVT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="87"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="186" mass="20813" checksum="EB50E1B4F2B3B058" modified="2009-03-03" version="1">MEAIAVVCGFSAEGGSRNYRFSTYDDCSDLADALILYRKRAIPPSSFFLRAESFFTMATQARDYDRGRSAMSALHEMSHGEGFLEIMLSRNAPGLYLMDEPESALSAGRQLALLAHMHRLAEQGAQFIVATHSPILLGLPGAQILQFDDDGVRPCDYEDTDAYRITASFINHRDVLLRHLFTDEER</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTI5</accession>
    <name>PTH_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="1">PTH</shortName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pth</name>
        <name type="ordered locus">BLA_1024</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PTH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217710.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DTI5"/>
    <dbReference type="SMR" id="B8DTI5"/>
    <dbReference type="STRING" id="442563.BLA_1024"/>
    <dbReference type="EnsemblBacteria" id="ACL29314">
        <property type="protein sequence ID" value="ACL29314"/>
        <property type="gene ID" value="BLA_1024"/>
    </dbReference>
    <dbReference type="GeneID" id="66533364"/>
    <dbReference type="KEGG" id="bla:BLA_1024"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1070"/>
    <dbReference type="HOGENOM" id="CLU_062456_3_1_11"/>
    <dbReference type="OMA" id="SQWLGTR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00083">
        <property type="entry name" value="Pept_tRNA_hydro_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000192959" description="Peptidyl-tRNA hydrolase">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00083"/>
        </source>
    </evidence>
    <sequence length="199" mass="22001" checksum="DE8DC73344BE8C89" modified="2009-03-03" version="1">MASEFWLIVGLGNPGAKYRNTRHNMGFMTVNELAKRWSIHFANHKGLADLGKGTMSLNGQTAKVFLCKPLTYMNDSGQAVQSIREYYHINLDHIVVIHDDMDLEFGRIKLKSGGSAGGHNGIKSIDRCLHSPDYARVRMGVGHASRSGDAHDNTINWVLGEFNAAQRKQLPEFLADGADAAETIVFEGLTKAQDKFNAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTI9</accession>
    <name>ENO_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enolase</fullName>
            <ecNumber evidence="1">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">eno</name>
        <name type="ordered locus">BLA_1030</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell surface</location>
        </subcellularLocation>
        <text evidence="1">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269110.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DTI9"/>
    <dbReference type="SMR" id="B8DTI9"/>
    <dbReference type="STRING" id="442563.BLA_1030"/>
    <dbReference type="EnsemblBacteria" id="ACL29318">
        <property type="protein sequence ID" value="ACL29318"/>
        <property type="gene ID" value="BLA_1030"/>
    </dbReference>
    <dbReference type="GeneID" id="66533359"/>
    <dbReference type="KEGG" id="bla:BLA_1030"/>
    <dbReference type="HOGENOM" id="CLU_031223_2_1_11"/>
    <dbReference type="OMA" id="EFMIIPV"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <feature type="chain" id="PRO_1000132985" description="Enolase">
        <location>
            <begin position="1"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="1">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="364"/>
            <end position="367"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <sequence length="430" mass="46461" checksum="3BF62B3E77B9D561" modified="2009-03-03" version="1">MAAIESVYARQILDSRGNPTVEVVLDTDDGARGLGLVPSGASTGEAEAWERRDGDKSVYQGKGVLGAVKAVNEEIAPKVIGMDATDQRALDDLMIELDGTPNKGRLGANAILGVSLAALYAAAESAELPLYRYIGGTNGHVLPVPNMNIMNGGAHADFATDIQEYMISPYGFQTYSEALQAGVEVYHTLKNVLKKQGLATGLGDEGGFAPKMKTNEDSLKYIMDAISAAGYEPGKQIGIALDVASSEFYNKETGKYHFDGEDRDSEYMLDFYEKLVDQFPIVSIEDPFQEEGWEDWAKITKALGDRLQFVGDDLFVTNPVRLKKGIDMGAGNSLLVKLNQIGTVSETLDAIELATKNGFTSMVSHRSGETPDTTISDLAVAKNTGQIKTGAPARGERIAKYNRLLEIEEELGSTAEYAGYSAFKACRKYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTL8</accession>
    <name>B8DTL8_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 13">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="7">IMP dehydrogenase</shortName>
            <shortName evidence="7">IMPD</shortName>
            <shortName evidence="7">IMPDH</shortName>
            <ecNumber evidence="7 13">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 15" type="primary">guaB</name>
        <name evidence="15" type="ordered locus">BLA_1059</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>H2O + IMP + NAD(+) = H(+) + NADH + XMP</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 13">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 12">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="7 13"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218753.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="SMR" id="B8DTL8"/>
    <dbReference type="STRING" id="442563.BLA_1059"/>
    <dbReference type="EnsemblBacteria" id="ACL29347">
        <property type="protein sequence ID" value="ACL29347"/>
        <property type="gene ID" value="BLA_1059"/>
    </dbReference>
    <dbReference type="GeneID" id="66532888"/>
    <dbReference type="KEGG" id="bla:BLA_1059"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1107"/>
    <dbReference type="HOGENOM" id="CLU_022552_2_1_11"/>
    <dbReference type="OMA" id="MGYCGAK"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3 7 13" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="2 7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 13" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 13" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="14">
        <location>
            <begin position="107"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="14">
        <location>
            <begin position="170"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7">
        <location>
            <begin position="356"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7">
        <location>
            <begin position="379"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7">
        <location>
            <begin position="403"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="7 8">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="264"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <begin position="316"/>
            <end position="318"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ACL29347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="511" mass="54272" checksum="9285A5CAD6D295BF" modified="2009-03-03" version="1">MATIPNAESPYTPLPPIFAQLGLAYDDVLLLPNETDVIPSEVDTSTHLTRNITMKVPVLSAAMDTVTEADMAIAMARNGGIGVLHRNLSIDDQAAQVDVVKRSESGMITDPLTVNPDATLADLDKLCGKFHISGLPVVDHDNKLVGIITNRDMRFIASEDYDHLRVKDVMTKENLVTGPSDISKKDAHDLLAKNKIEKLPLVDGEGHLTGLITVKDFVKTEQYPDATKDGQGRLRVAAGIGYLGDAWQRASALMEAGVDVLVVDTANGEAKIALDMIRRIKNDSAFNGVDIIGGNIATRQGAQAMIDAGVDAVKVGVGPGSICTTRVVAGVGVPQLTAVYEAAQACRAAGVPCIADGGIHYSGDIAKALVAGASSVMLGGVLAGTEEAPGEKVLLHGKQYKLYRGMGSMGAMAPRGKKSYSKDRYFQSDVTSTDKIVPEGVEGEVPYRGPLGAVLYQMIGGLHQSMFYIGAHNIAEMSEKGRFIRITDAGLRESHPHDIVMTAEAPNYSGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTM3</accession>
    <name>SYP_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Proline--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="1">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">proS</name>
        <name type="ordered locus">BLA_1064</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DTM3"/>
    <dbReference type="SMR" id="B8DTM3"/>
    <dbReference type="STRING" id="442563.BLA_1064"/>
    <dbReference type="EnsemblBacteria" id="ACL29352">
        <property type="protein sequence ID" value="ACL29352"/>
        <property type="gene ID" value="BLA_1064"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1064"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1113"/>
    <dbReference type="HOGENOM" id="CLU_016739_2_2_11"/>
    <dbReference type="OMA" id="NCDYAAN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00861">
        <property type="entry name" value="ProRS_anticodon_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01569">
        <property type="entry name" value="Pro_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004500">
        <property type="entry name" value="Pro-tRNA-synth_IIa_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023717">
        <property type="entry name" value="Pro-tRNA-Synthase_IIa_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044140">
        <property type="entry name" value="ProRS_anticodon_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00409">
        <property type="entry name" value="proS_fam_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000185488" description="Proline--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01569"/>
        </source>
    </evidence>
    <sequence length="599" mass="66686" checksum="59489BDC7A32E159" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTM8</accession>
    <name>B8DTM8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218765.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1069"/>
    <dbReference type="EnsemblBacteria" id="ACL29357">
        <property type="protein sequence ID" value="ACL29357"/>
        <property type="gene ID" value="BLA_1069"/>
    </dbReference>
    <dbReference type="GeneID" id="66532896"/>
    <dbReference type="KEGG" id="bla:BLA_1069"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1118"/>
    <dbReference type="HOGENOM" id="CLU_091585_4_1_11"/>
    <dbReference type="OMA" id="GIGWLFR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005325">
        <property type="entry name" value="DUF308_memb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03729">
        <property type="entry name" value="DUF308"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="206" mass="22048" checksum="44EB6AB12AFCC2E3" modified="2009-03-03" version="1">MSEPNPQYQNQQYNQSPFRLFEGMLPTGAKNLVRGTYGVIGVAALALGICLLVWPGITLKVAAIVLGIYFLISGVVRIVSSLVEMGLPAGWRILGVLIGIILVIGGIVIFKNVTMSTAMLAIMFTLIVGICWIMEGVMALAESWSVPSSGWAIAYAIISIIAGFVLLCMPMASTLWLIIFGGCAMVVMGICAIVRAFTFGRVKKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTP4</accession>
    <name>B8DTP4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator of two-component system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_1085</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1085"/>
    <dbReference type="EnsemblBacteria" id="ACL29373">
        <property type="protein sequence ID" value="ACL29373"/>
        <property type="gene ID" value="BLA_1085"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1085"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_3_11"/>
    <dbReference type="OMA" id="MSMREMS"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="9"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="157"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="224" mass="24854" checksum="57969B6340DA8AE0" modified="2009-03-03" version="1">MNPDSEPWNIALVDNDALVRSYLETYLGGLPEFNICWSMQSGRDAVEAYHHSIACTNCVPDLIVTDLSMHGMSGFELCATIRFENDHTPILGCSSYMIEPYERDAVNNGMQGLLLKNELAQLADGMRTLLSGQPLLKSNGMPYETPQQAHERLLMQGKPAIMSMSPNEQAVMELCSEGLSTRTIAEETGDSESTVKTYISRAMRKLRAKSRAEAVASWSRKTKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTP8</accession>
    <name>COAX_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Type III pantothenate kinase</fullName>
            <ecNumber evidence="1">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">PanK-III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaX</name>
        <name type="ordered locus">BLA_1089</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NH4(+)</name>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
        </cofactor>
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="1">A monovalent cation. Ammonium or potassium.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type III pantothenate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218800.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DTP8"/>
    <dbReference type="SMR" id="B8DTP8"/>
    <dbReference type="STRING" id="442563.BLA_1089"/>
    <dbReference type="EnsemblBacteria" id="ACL29377">
        <property type="protein sequence ID" value="ACL29377"/>
        <property type="gene ID" value="BLA_1089"/>
    </dbReference>
    <dbReference type="GeneID" id="66532915"/>
    <dbReference type="KEGG" id="bla:BLA_1089"/>
    <dbReference type="HOGENOM" id="CLU_066627_1_0_11"/>
    <dbReference type="OMA" id="HEPWLTL"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01274">
        <property type="entry name" value="Pantothen_kinase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004619">
        <property type="entry name" value="Type_III_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34265">
        <property type="entry name" value="PTHR34265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03309">
        <property type="entry name" value="Pan_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00671">
        <property type="entry name" value="baf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000165188" description="Type III pantothenate kinase">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="107"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01274"/>
        </source>
    </evidence>
    <sequence length="252" mass="26948" checksum="56FDDB8F8834DD13" modified="2009-03-03" version="1">MILAVDIGNTNIVIGLMEGTETVDTYRITTRSNHTSDEYGLMILQFLQLSNSSPDDVQDAIISSVVPKVMHSFISSMIKFLGIDPMIIGPGIKTGMNIRMDDPRSLGADLLADCAGAYTTYGGPVLVIDMGTATTYNYVDEKGAILAGLITTGIGTAAAALASNTAQLPEVQITRPKSILAANTKDAMQAGLYYDCLGGIERTITQFREELDTDFKVVATGGMSRIFDCPLIDIVDPTLIFKGMASIYAKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTQ5</accession>
    <name>B8DTQ5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cystathionine beta-synthase</fullName>
            <ecNumber evidence="4">4.2.1.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cbsSV</name>
        <name evidence="4" type="ordered locus">BLA_1096</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="4"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218807.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1096"/>
    <dbReference type="EnsemblBacteria" id="ACL29384">
        <property type="protein sequence ID" value="ACL29384"/>
        <property type="gene ID" value="BLA_1096"/>
    </dbReference>
    <dbReference type="GeneID" id="66532922"/>
    <dbReference type="KEGG" id="bla:BLA_1096"/>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_11"/>
    <dbReference type="OMA" id="WMADYGF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="8"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="339" mass="36150" checksum="A515BA6321979BD3" modified="2009-03-03" version="1">MAIHTTVAELIGNTPLVELHNVTDGVRAKIAVKVEYFNPGGSSKDRIAERIIGAAEREGKLRPGGVIVEPTSGNTGVGLALVAQQRGYRTVFVLPDKVSETKRAVLRAYGAEVVVTPTDVEPDDPRSYYSVSDRLAREIPGAFKPNQYSNLNGPRSHYETTGPEIWEASEGGVTHFVAGIGTGGTISGTGRYLKEVSNGAVTVIGADPEGSIYSSPANVHGYDIEGVGEDFYPSAFDQTIPDAVEQVTDGEAFLMTRRLAAEEGLLVGGSSGMAVAAAVRYAREHDLDESATVVVLLPDSGRGYLEKIFNDDWMIEHGYADIVARTSRPSLVDGVLLEV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTW1</accession>
    <name>NUSB_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription antitermination protein NusB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Antitermination factor NusB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nusB</name>
        <name type="ordered locus">BLA_1152</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NusB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218883.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DTW1"/>
    <dbReference type="SMR" id="B8DTW1"/>
    <dbReference type="STRING" id="442563.BLA_1152"/>
    <dbReference type="EnsemblBacteria" id="ACL29440">
        <property type="protein sequence ID" value="ACL29440"/>
        <property type="gene ID" value="BLA_1152"/>
    </dbReference>
    <dbReference type="GeneID" id="66532977"/>
    <dbReference type="KEGG" id="bla:BLA_1152"/>
    <dbReference type="HOGENOM" id="CLU_087843_2_3_11"/>
    <dbReference type="OMA" id="DRMPVVD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00073">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011605">
        <property type="entry name" value="NusB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11078">
        <property type="entry name" value="PTHR11078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01951">
        <property type="entry name" value="nusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0889">Transcription antitermination</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_1000192416" description="Transcription antitermination protein NusB">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="154" mass="17239" checksum="7F756014A29F1902" modified="2009-03-03" version="1">MARSTARRRALNTLYEADEKGQDFLSLLDERIAQPGAQTPLPEYAIEIVRGVDEHRRDIDSQLNTHSTGWKVKRMHAIDRNILRIATWEILYNDDVPDKVAIDEALNLSKTLSDDAAPSFIHGVLSAIVAAKDKQSPQSTPLDDSDKDESDQTN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-08-10" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTX4</accession>
    <name>ARC_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA ATPase forming ring-shaped complexes</fullName>
            <shortName evidence="1">ARC</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">arc</name>
        <name type="ordered locus">BLA_1165</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homohexamer. Assembles into a hexameric ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218902.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DTX4"/>
    <dbReference type="SMR" id="B8DTX4"/>
    <dbReference type="STRING" id="442563.BLA_1165"/>
    <dbReference type="EnsemblBacteria" id="ACL29453">
        <property type="protein sequence ID" value="ACL29453"/>
        <property type="gene ID" value="BLA_1165"/>
    </dbReference>
    <dbReference type="GeneID" id="66532990"/>
    <dbReference type="KEGG" id="bla:BLA_1165"/>
    <dbReference type="HOGENOM" id="CLU_036054_0_0_11"/>
    <dbReference type="OMA" id="CVDEFKE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02112">
        <property type="entry name" value="ARC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041626">
        <property type="entry name" value="Prot_ATP_ID_OB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022482">
        <property type="entry name" value="Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17758">
        <property type="entry name" value="Prot_ATP_OB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03689">
        <property type="entry name" value="pup_AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000396964" description="AAA ATPase forming ring-shaped complexes">
        <location>
            <begin position="1"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="248"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="522" mass="56906" checksum="01B79ADEB6322CA5" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-08-10" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTX8</accession>
    <name>PAFA_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pup--protein ligase</fullName>
            <ecNumber evidence="1">6.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Proteasome accessory factor A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pup-conjugating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pafA</name>
        <name type="ordered locus">BLA_1169</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + [prokaryotic ubiquitin-like protein]-L-glutamate + [protein]-L-lysine = ADP + phosphate + N(6)-([prokaryotic ubiquitin-like protein]-gamma-L-glutamyl)-[protein]-L-lysine.</text>
            <dbReference type="EC" id="6.3.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein pupylation.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">The reaction mechanism probably proceeds via the activation of Pup by phosphorylation of its C-terminal glutamate, which is then subject to nucleophilic attack by the substrate lysine, resulting in an isopeptide bond and the release of phosphate as a good leaving group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.19" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218911.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DTX8"/>
    <dbReference type="SMR" id="B8DTX8"/>
    <dbReference type="STRING" id="442563.BLA_1169"/>
    <dbReference type="EnsemblBacteria" id="ACL29457">
        <property type="protein sequence ID" value="ACL29457"/>
        <property type="gene ID" value="BLA_1169"/>
    </dbReference>
    <dbReference type="GeneID" id="66532994"/>
    <dbReference type="KEGG" id="bla:BLA_1169"/>
    <dbReference type="HOGENOM" id="CLU_040524_0_1_11"/>
    <dbReference type="OMA" id="CVSQRAE"/>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="UniPathway" id="UPA00998"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019787">
        <property type="term" value="F:ubiquitin-like protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070490">
        <property type="term" value="P:protein pupylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02111">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022279">
        <property type="entry name" value="Pup_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004347">
        <property type="entry name" value="Pup_ligase/deamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42307">
        <property type="entry name" value="PTHR42307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03136">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="chain" id="PRO_0000395896" description="Pup--protein ligase">
        <location>
            <begin position="1"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02111"/>
        </source>
    </evidence>
    <sequence length="496" mass="55439" checksum="24574FD9C873927A" modified="2009-03-03" version="1">MPQLHDSGSRAIQPSDQTHQHDFARIFGIETEYGVSVTDIPEPMDASHVAMTMFQPVVRRARSTNTYVENGSRLYLDVGSHPEYATAEAICPSDALLSDLAGEQTMRSMGLDAQRRLRESDAQNRHATLHLYKNNADSAGHSFGCHENYLVRRFVNLDMIQHVLLPFLITRQIYTGAGRFDGERLLFTQRAAFVDETVSSATTRSRPMINTRDEPHANPDDYRRLHVIIGDSNRSQWATLMKCATTHLVLCMMEHAARSGCETELEAFALADPIAANHAINTDGAHARIALAAGRSTTALELQQMMLEQVESFAAHHGDALEASLRYDALCNVEWIVGQWRWVLDRLAANDIETLSHVVDWASKQVFFNRLQSRGTVTPARLRQLDLDYHDIANGRLYPSLCAHGLMRTLVDADQIHDAVSTPPPHTRAVLRGRFVAAASHTDAVYDCDWTTLKLVRPVHMEAVLLDPFHDEPTKQYDKLMGELGDARADGDEAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTZ1</accession>
    <name>B8DTZ1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell wall integrity and stress response component 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_1182</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218933.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1182"/>
    <dbReference type="EnsemblBacteria" id="ACL29470">
        <property type="protein sequence ID" value="ACL29470"/>
        <property type="gene ID" value="BLA_1182"/>
    </dbReference>
    <dbReference type="GeneID" id="66533007"/>
    <dbReference type="KEGG" id="bla:BLA_1182"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1242"/>
    <dbReference type="HOGENOM" id="CLU_110134_0_0_11"/>
    <dbReference type="OMA" id="TVVWYQN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="3">
        <location>
            <begin position="143"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="227" mass="23649" checksum="148BD478EF6196EB" modified="2009-03-03" version="1">MARNDDHKYESYPKDSFDNPPTGPVGVHNGRRSWPVRLTPYAIVIVVAAAVGVLFWSAFSGEAANMFKHGDRETVVASSSTTTTTSPSSTSASESESPSQSASASASESPSQSPSQSPSQSSESPSQSPSEEQTPEQKVNLDASISVINGTATNGYAAQEAQRLQGAGFTNVAPSNPNGMQLPSQSVVWYQNDADLATAQKVAETLGVSTVQKAEGIAVPVAVVLMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU01</accession>
    <name>B8DU01_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">clpC</name>
        <name evidence="13" type="ordered locus">BLA_1192</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AD011</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218154.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1192"/>
    <dbReference type="EnsemblBacteria" id="ACL29480">
        <property type="protein sequence ID" value="ACL29480"/>
        <property type="gene ID" value="BLA_1192"/>
    </dbReference>
    <dbReference type="GeneID" id="66533018"/>
    <dbReference type="KEGG" id="bla:BLA_1192"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1254"/>
    <dbReference type="HOGENOM" id="CLU_005070_4_2_11"/>
    <dbReference type="OMA" id="ERMKAVM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="12">
        <location>
            <begin position="2"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="11">
        <location>
            <begin position="428"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="824"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="424"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACL29480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="850" mass="94226" checksum="091E504604C240D6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU33</accession>
    <name>B8DU33_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_1224</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218112.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1224"/>
    <dbReference type="EnsemblBacteria" id="ACL29512">
        <property type="protein sequence ID" value="ACL29512"/>
        <property type="gene ID" value="BLA_1224"/>
    </dbReference>
    <dbReference type="GeneID" id="66533048"/>
    <dbReference type="KEGG" id="bla:BLA_1224"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1286"/>
    <dbReference type="HOGENOM" id="CLU_024839_0_0_11"/>
    <dbReference type="OMA" id="NMAYFTP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="4">
        <location>
            <begin position="10"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="127"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="370" mass="39609" checksum="8975D48D5C790410" modified="2009-03-03" version="1">MTDQTQIIETAVIERLSHVIDPELGRSVTDLGMICGVDVRPTGLDSFNVRVNVELTVPGCPLSAEISRQIEAAVTSYAEAQLTAEIVVGAMDEEKLKSLVNDLKAARRENPFSKPGTKTRIFAIASGKGGVGKSSISANLAATFAALGYDTAAIDADIYGFSLPRLFGVHDQPTNLNGMLMPVTAWGVKLMSIGMFAGSDRAILWRGPRLQRSLEQFLADVWWGEPDVLILDLAPGTGDMAISVAQALPNAELVVVTTPQPSASDIAVRSGLVALQVPMRVRGVVENMSYFEHAGERIDIFGTGGGARVSSQLTDALHYEVPLMAQLPLDPRIREIGESEGRPAVLNDDGTLRDDDFGRTFGHLAKSLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU72</accession>
    <name>B8DU72_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Possible hydrolyase with Pf00702 domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218058.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1263"/>
    <dbReference type="EnsemblBacteria" id="ACL29551">
        <property type="protein sequence ID" value="ACL29551"/>
        <property type="gene ID" value="BLA_1263"/>
    </dbReference>
    <dbReference type="GeneID" id="66533085"/>
    <dbReference type="KEGG" id="bla:BLA_1263"/>
    <dbReference type="HOGENOM" id="CLU_045011_13_1_11"/>
    <dbReference type="OMA" id="MGVWDQV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="227" mass="24980" checksum="FBCC55F50F06B380" modified="2009-03-03" version="1">MANMVNAAGVNSGRAAIFDLDGTLLDSMGVWDAVDVEFLGRRGFDVPADYMQKVSAMQFHDIAAYTIRRFGLDDTPEELMREWNDLAYEAYTTTVELKPGARAYLEWLRASGARLAVATSMLPSLREPAMRHAGIYDLFDVVVGTGDDGSSGKDNPVIFLHTAQLLGVKPAHCTVFEDLLTAVESAKRAGMHVWGVQDDSSAMHWERICETADGVLFDFTQAPRQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU74</accession>
    <name>B8DU74_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="7">GPR</shortName>
            <ecNumber evidence="7">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="7">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">proA</name>
        <name evidence="9" type="ordered locus">BLA_1265</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="7"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269080.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1265"/>
    <dbReference type="EnsemblBacteria" id="ACL29553">
        <property type="protein sequence ID" value="ACL29553"/>
        <property type="gene ID" value="BLA_1265"/>
    </dbReference>
    <dbReference type="GeneID" id="66533087"/>
    <dbReference type="KEGG" id="bla:BLA_1265"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1328"/>
    <dbReference type="HOGENOM" id="CLU_030231_0_0_11"/>
    <dbReference type="OMA" id="PGVCNAM"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0521">NADP</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="15"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL29553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="437" mass="46756" checksum="95E621F9434A9E39" modified="2009-03-03" version="1">MTNTNELQTPVSGDVQQAVNALADAAAIAQHELAQATADTKNGVLMAIADALDAHASDIADANAMDMQAAFDAGMDQGKLDRLKFDVIRVAAAAQGVRHVATLPDPVGEIVRGYDLGNGLRLQQQRVPLGVIGMIYEARPNVTVDVAALCLKSGNAAILRGGHAAERTNAATLQVIDEVLQELHFDPALVASVDRYGREGARAMMRATGHIDVLIPRGGAGLIQSVVHESRVPVIETGAGNVHIYVDSSADIDKAIDIVVNAKTQRVGVCNAAEKLIVHRDIARQFLPRMAQALARAHVTIHADELSMRIMGDADIKDIQLLAADEADWGTEYLALEIGVRIVDSLDEAIDHINRYSTHHTESILSQDYTNIERFTKAIDSAVVMVNASTRFTDGGVFGFGAELGISTQKLHARGPMGLQEMTTTKWVGYGNGQVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU75</accession>
    <name>B8DU75_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribosylformylglycinamidine (FGAM) synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1266"/>
    <dbReference type="EnsemblBacteria" id="ACL29554">
        <property type="protein sequence ID" value="ACL29554"/>
        <property type="gene ID" value="BLA_1266"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1266"/>
    <dbReference type="HOGENOM" id="CLU_107925_0_0_11"/>
    <dbReference type="OMA" id="DEWNEEM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="192" mass="21593" checksum="9084E91677EB2C81" modified="2009-03-03" version="1">MTEVVSDAPVNPWGLDLDDPFIALRLTAERLSLVRYVFVVQIEDGIATAGQRASLEYADAVLIGWPDEHAKGLDAPTDEDRRTIDEQIRLMEEYVDKFRTMEQDGDIDGMTDTLIRITERVARVRSIYQPKFLLPTFAEIRRVVQDEWDEDMGKIDSDTVMNDNGESGLAKDVQKAALDADEAGRGTDRASE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU78</accession>
    <name>GLMU_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bifunctional protein GlmU</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">UDP-N-acetylglucosamine pyrophosphorylase</fullName>
                <ecNumber evidence="1">2.7.7.23</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">N-acetylglucosamine-1-phosphate uridyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">Glucosamine-1-phosphate N-acetyltransferase</fullName>
                <ecNumber evidence="1">2.3.1.157</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="1" type="primary">glmU</name>
        <name type="ordered locus">BLA_1269</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="EC" id="2.3.1.157"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="1"/>
    <dbReference type="EC" id="2.3.1.157" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218050.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DU78"/>
    <dbReference type="SMR" id="B8DU78"/>
    <dbReference type="STRING" id="442563.BLA_1269"/>
    <dbReference type="EnsemblBacteria" id="ACL29557">
        <property type="protein sequence ID" value="ACL29557"/>
        <property type="gene ID" value="BLA_1269"/>
    </dbReference>
    <dbReference type="GeneID" id="66533092"/>
    <dbReference type="KEGG" id="bla:BLA_1269"/>
    <dbReference type="HOGENOM" id="CLU_029499_15_2_11"/>
    <dbReference type="OMA" id="TAIVEHK"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00532"/>
    </dbReference>
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        <property type="reaction ID" value="UER00533"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019134">
        <property type="term" value="F:glucosamine-1-phosphate N-acetyltransferase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
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        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
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        <property type="term" value="P:cell morphogenesis"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:lipid A biosynthetic process"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="glmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000186405" description="Bifunctional protein GlmU">
        <location>
            <begin position="1"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyrophosphorylase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
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        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
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            <begin position="257"/>
            <end position="460"/>
        </location>
    </feature>
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    </feature>
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        <location>
            <begin position="9"/>
            <end position="12"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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            <position position="428"/>
        </location>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_01631"/>
        </source>
    </evidence>
    <sequence length="460" mass="49207" checksum="B119D1136CDA4C7A" modified="2009-03-03" version="1">MTLTAAIVLAAGEGTRMRSRKPKVLHEFAGKTFLNRVMDAVGALDPETLAVVVRYQAQRVAEAARSYDDAVLIVEQDEIPGTGRAVQCAMEQLGEQGPLSGTVLITASDMPLLDTSTLKQLLDYHRDSGDGATVLTTVLDDPTGYGRIIRDADGNVLKIVEQKDGNSSELAVREVNTSVYVFDAAVLEQAIANLNADNAQGEFYLTDALTVARQVSKVGAFAAPDPLSVEGVNDRVQLASLAKAHNLRVCRQWMLDGVTIVDPQTTWIEDEVEMESDAVILPGCFLQGHTTIAHDAVVGPYTTLIDATVEPEAHVERSRVQESRIGREANIGPWTYLRPGNEIGTGSKAGAFVEMKKAHIGDGSKVPHLSYVGDADLGENTNIGGGTITANYDGVHKNHTHIGSDVHIGAGNLFVAPVNVGDGVTSGAGSVIRHDVPGDAMVYSENTQHVVDNWKPAWER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU94</accession>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ACL29573"/>
        <property type="gene ID" value="BLA_1286"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="ACL29573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="94" mass="10280" checksum="2834EC369620C846" modified="2009-03-03" version="1">MTMIDAFRCVDDAVLLVSPWSSLDFGIFGCTGSIFSLIGFAGHKTVAYCADFSLCCILRASEKMTVVPYESGEYADTPDLRIQSIVCKLYVCCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUB4</accession>
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        <submittedName>
            <fullName evidence="3">Anthranilate synthase component I</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="primary">trpE</name>
        <name evidence="3" type="ordered locus">BLA_1306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="NC_011835.1"/>
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    </dbReference>
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    <dbReference type="KEGG" id="bla:BLA_1306"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADC_synthase"/>
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        <property type="entry name" value="Anth_synth_I-like"/>
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        <property type="entry name" value="Anth_synth_I_N"/>
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        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="2">
        <location>
            <begin position="42"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="1">
        <location>
            <begin position="244"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="519" mass="56903" checksum="3EC13C6D014E4529" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUC9</accession>
    <name>B8DUC9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, MerR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269092.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1321"/>
    <dbReference type="EnsemblBacteria" id="ACL29608">
        <property type="protein sequence ID" value="ACL29608"/>
        <property type="gene ID" value="BLA_1321"/>
    </dbReference>
    <dbReference type="GeneID" id="66533146"/>
    <dbReference type="KEGG" id="bla:BLA_1321"/>
    <dbReference type="HOGENOM" id="CLU_092079_0_0_11"/>
    <dbReference type="OMA" id="IAVGVVW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="53"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="243" mass="26750" checksum="EA3E558803F4A7E6" modified="2009-03-03" version="1">MESNRETQAQREGRNDGLPLFVDVPLLDVDDSMVQGELFPDSLLETEQVRMGYRGSAASRAAGITYRQLDYWAHKHIVEPSVTASHGSGSRRLYSFNDVLMLAACKKLLDLGVNLQNISQTLQFLRAYRSTQLSHMVIVCDGEHVRACEGETMFADVLQHESAVFIIAVGALFRQVESSLAAAESVAVTSDVALRHLSVDSDGPLARLPIVAKGTRLHHRDAHVEPPYRDVPLDIDGHSYAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUH1</accession>
    <name>B8DUH1_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Triosephosphate isomerase</fullName>
            <shortName evidence="3">TIM</shortName>
            <shortName evidence="3">TPI</shortName>
            <ecNumber evidence="3 4">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">tpiA</name>
        <name evidence="5" type="ordered locus">BLA_1365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="3 4"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217924.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1365"/>
    <dbReference type="EnsemblBacteria" id="ACL29650">
        <property type="protein sequence ID" value="ACL29650"/>
        <property type="gene ID" value="BLA_1365"/>
    </dbReference>
    <dbReference type="GeneID" id="66533196"/>
    <dbReference type="KEGG" id="bla:BLA_1365"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1428"/>
    <dbReference type="HOGENOM" id="CLU_024251_2_3_11"/>
    <dbReference type="OMA" id="QEVCGAI"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="3 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="13"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="244"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="3">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="270" mass="29533" checksum="DEA1E5B0325BDC82" modified="2009-03-03" version="1">MASTRRIPMVAGNWKMNFDHLEATEFVRAFSKNLKRCHFDFNRCEVALFPSFTSIRSVQVMVESEHLRIRYGAQAVSVTSQGAFTGDVSADMLAHLGCSYVIVGHSERRKYHPEDDANIVDQVRAVLAAGMQPILCVGESLEERRKGIELEFAVGQVHDVTRDLSDGEASKLIIAYEPVWAIGTGMVATPQTAQDAAHAFRVDLAKSFGDHVAQTVRVLYGGSVSSKNCVELIEEPDVDGFLIGGAALDVDELTTICRKTIATTSSHDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUJ1</accession>
    <name>B8DUJ1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted GTPase, probable translation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1385"/>
    <dbReference type="EnsemblBacteria" id="ACL29670">
        <property type="protein sequence ID" value="ACL29670"/>
        <property type="gene ID" value="BLA_1385"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1385"/>
    <dbReference type="HOGENOM" id="CLU_052626_8_0_11"/>
    <dbReference type="OMA" id="LNCPQVN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007569">
        <property type="entry name" value="DUF559"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04480">
        <property type="entry name" value="DUF559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF559" evidence="1">
        <location>
            <begin position="49"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="143" mass="16676" checksum="BE74ECE4480A5D2A" modified="2009-03-03" version="1">MKCRKALPLMAQGTDSVAETMLRLILIRYGLPIPCVNYQLVLRDGSLVFLDLAYPEAKIDIEYDGRHHRYQWARDAQRTMKIRAEGWEYFQVTSEMLSDDEQMFMVVVLVARCLKERTGKDYLLPQPLTLEQAADQRRAVWHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUJ8</accession>
    <name>B8DUJ8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable dihydroorotate dehydrogenase electron transfer subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pyrK</name>
        <name evidence="7" type="ordered locus">BLA_1392</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="5">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PyrK family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217890.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1392"/>
    <dbReference type="EnsemblBacteria" id="ACL29677">
        <property type="protein sequence ID" value="ACL29677"/>
        <property type="gene ID" value="BLA_1392"/>
    </dbReference>
    <dbReference type="GeneID" id="66533222"/>
    <dbReference type="KEGG" id="bla:BLA_1392"/>
    <dbReference type="HOGENOM" id="CLU_003827_1_2_11"/>
    <dbReference type="OMA" id="RYMKCGI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037117">
        <property type="entry name" value="Dihydroorotate_DH_ele_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="19"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="91"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="279" mass="30102" checksum="1EB2B2CD556698FD" modified="2009-03-03" version="1">MPTAFTRTVEQAQEAGFTPTRRTVSIVAVKQLTAGIVRLTFRDEYIAHHVRPAQFVNLYSSNPMHLMPRPFGVSEVDGDEVSLIFAVVGFGTDEFSKLTAGDTIDVLGPLGTPFNLDEAADYVLVGGGLGIPPLLEAAQSLRDEADSRAIAVFGYRDEHFADIYAAKYADEVHSIDESEGNVLTLLERLWPALEESGRKTIILSCGPTPMMRAVATWASKRGVDAQLSMEQRMGCGYGTCVACTIDTRAGREKVCEAGPVFTAHQLGWDADGAEANADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUL1</accession>
    <name>B8DUL1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative bacterioferritin comigratory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bcp</name>
        <name evidence="5" type="ordered locus">BLA_1405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217876.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1405"/>
    <dbReference type="EnsemblBacteria" id="ACL29690">
        <property type="protein sequence ID" value="ACL29690"/>
        <property type="gene ID" value="BLA_1405"/>
    </dbReference>
    <dbReference type="GeneID" id="66533234"/>
    <dbReference type="KEGG" id="bla:BLA_1405"/>
    <dbReference type="HOGENOM" id="CLU_042529_14_1_11"/>
    <dbReference type="OMA" id="RVVVYFY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="9"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="161" mass="18522" checksum="101D6A419838AF77" modified="2009-03-03" version="1">MSENNIVRLNKGDKAPNFELESDEYKHYALADFKHQNVVLYFYPKAGTSVCTREAKDFRDNLERFQAEGYAVIGISPDDVKALQEFRKSNDLNFILLSDPEFTVHKLYGAAKEHEKDGKETYETIRSTFVLDGDDTIRFAGYDVNVNGQIDELLEQIEKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUM4</accession>
    <name>B8DUM4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P) transhydrogenase subunit alpha part 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pntA</name>
        <name evidence="5" type="ordered locus">BLA_1418</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217856.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1418"/>
    <dbReference type="EnsemblBacteria" id="ACL29703">
        <property type="protein sequence ID" value="ACL29703"/>
        <property type="gene ID" value="BLA_1418"/>
    </dbReference>
    <dbReference type="GeneID" id="66533247"/>
    <dbReference type="KEGG" id="bla:BLA_1418"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1482"/>
    <dbReference type="HOGENOM" id="CLU_003376_2_1_11"/>
    <dbReference type="OMA" id="YFPMLMT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008143">
        <property type="entry name" value="Ala_DH/PNT_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00837">
        <property type="entry name" value="ALADH_PNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlaDh_PNT_N" evidence="4">
        <location>
            <begin position="12"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="3">
        <location>
            <begin position="156"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="384" mass="39991" checksum="D79ED1DE752641E8" modified="2009-03-03" version="1">MAQTPEANVVFGVFNETSDHESRVALTPDTVTRLRKAGVTCMIEQGAGNAAAYTDEDYAKVGATVCTADDILAKADALGFVDRPSEQMIGRIKPGTWVIGMLSSFTDEDYVAALASAGITAVAIERLPRQLSSAQSMDEMTSQNSVMGYKAVLVAANAYGSFLPMMTTAAGTIRPAKMLILGAGIAGLQAIGTARRLGAVVTAYDVRPASKSEVESLGAKFLDLGIDLSRGQGEGGYARALSAEEQAQQQAAVDRKAAEFDIIITTAKVPGRKPPMLLTKAGVGGLHRGSVIVDCAASELGGNVEGSQIGTQVTDGGVTVIGAPYLASEVSTTASNLLSRNVADVLAHFLVNGRLEVRQGEELDDAMVVAHTHADSNDDKKKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUP0</accession>
    <name>B8DUP0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FeS assembly protein SufB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sufB</name>
        <name evidence="3" type="ordered locus">BLA_1434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1434"/>
    <dbReference type="EnsemblBacteria" id="ACL29719">
        <property type="protein sequence ID" value="ACL29719"/>
        <property type="gene ID" value="BLA_1434"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1434"/>
    <dbReference type="HOGENOM" id="CLU_026231_0_1_11"/>
    <dbReference type="OMA" id="YYSAPKQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010231">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01980">
        <property type="entry name" value="sufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="2">
        <location>
            <begin position="72"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="401" mass="44101" checksum="6B836A03A3723AFD" modified="2009-03-03" version="1">MGCGSFGIPRAGFQVLCQARRQAAASWEDLPEDIRTTYDRLGIPEAEKSRLVSGVAAQYESEVIYNSIQDDLSKQGVIFVDTDTAVREYPELVQKYFGTVVPPEDNKFGALNTAAWSGGSFVYVPKGVHVDIPLQAYFRINTPNMGQFERTLIIADEGSYVHYVEGCTAPIYSTDSLHAAIVEIIVEKNARVRYTTVQNWSNNVYNLVTQRAYVREGATMEWVDGNIGSKATMKYPACILAEPYASASTMSLGFAGKGQYQDTGAKMIHLPPHTSSTIVAKSISRGGGRSAYRGLVKIVDGAEGSSSNVVCDALLVDDFSRSDTYPHVDVREDDVSMAHEATVSKVSEDQLFYLMSRGIEEKEAMAMIVRGFVEPISRELPMEYALELNRLVELQMEGSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUR7</accession>
    <name>B8DUR7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217803.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1463"/>
    <dbReference type="EnsemblBacteria" id="ACL29746">
        <property type="protein sequence ID" value="ACL29746"/>
        <property type="gene ID" value="BLA_1463"/>
    </dbReference>
    <dbReference type="GeneID" id="66533292"/>
    <dbReference type="KEGG" id="bla:BLA_1463"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1530"/>
    <dbReference type="HOGENOM" id="CLU_065086_0_0_11"/>
    <dbReference type="OMA" id="FKWKYPL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022208">
        <property type="entry name" value="DUF3737"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12541">
        <property type="entry name" value="DUF3737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="281" mass="32183" checksum="9D08A6DD463E113C" modified="2009-03-03" version="1">MQAITQQLLSGERALFQGRDLQITDCVFEDGESPLKESRNIVVRDSVFRWKYPLWYSEGVEVEHSLFEFNAHAAFWYSKNMTFHDCTIQAPKEFRRNEHVTVERTAFTDAAETFWECRKVTLREVSAAGDYFAMNSENLDIRDFQLTGNYCFDGARNVTVDHARLISKDAFWNCENVTVRNSFISGEYLAWNTKNITFENCTIESLQGLCYIDGLTMRDCRLINTTRSFEYCSDIDADVTTRIDSVVNPISGVIRAAAFGDVLQNDPAIDTTKIQLISTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUS7</accession>
    <name>B8DUS7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014482938.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29756">
        <property type="protein sequence ID" value="ACL29756"/>
        <property type="gene ID" value="BLA_1474"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1474"/>
    <dbReference type="HOGENOM" id="CLU_1096965_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="253" mass="28419" checksum="973A9258BE2F0852" modified="2009-03-03" version="1">MTSPSILPDDPSLCIPPMESDDENELNSQTAHNRAMVEYSARCGCFHCGGIFAGNEVAQWLQEDDGEDTALCPYCGVDAVIVGNEQYPVCMMVLSKLYMHWFGKEYRQRLEAATDMPTCGSHGDYLRKGLPSLTNHDRKITVVGEIELFPLSVYDRAEELCNESHPPRPVEYDDVDVYMGGVVTVHAGFDEHGYYYCDFITGSGVKLPYDAWNDVQQDLVLNLSRQYGDALRGIITDSLMHHMRLFIDVDVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUV8</accession>
    <name>B8DUV8_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,4-alpha-glucan branching enzyme GlgB</fullName>
            <ecNumber evidence="9">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Alpha-(1-&gt;4)-glucan branching enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glycogen branching enzyme</fullName>
            <shortName evidence="9">BE</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">glgB</name>
        <name evidence="12" type="ordered locus">BLA_1505</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="9"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269105.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1505"/>
    <dbReference type="CAZy" id="CBM48">
        <property type="family name" value="Carbohydrate-Binding Module Family 48"/>
    </dbReference>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29787">
        <property type="protein sequence ID" value="ACL29787"/>
        <property type="gene ID" value="BLA_1505"/>
    </dbReference>
    <dbReference type="GeneID" id="66533337"/>
    <dbReference type="KEGG" id="bla:BLA_1505"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1575"/>
    <dbReference type="HOGENOM" id="CLU_004245_3_2_11"/>
    <dbReference type="OMA" id="FGMKWMM"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02855">
        <property type="entry name" value="E_set_GBE_prok_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00685">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006407">
        <property type="entry name" value="GlgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044143">
        <property type="entry name" value="GlgB_N_E_set_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="PTHR43651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01515">
        <property type="entry name" value="branching_enzym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="11">
        <location>
            <begin position="277"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9 10">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACL29787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="750" mass="85019" checksum="C2EBA69978D699B3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUZ8</accession>
    <name>B8DUZ8_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin reductase</fullName>
            <ecNumber evidence="3">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">trxB</name>
        <name evidence="6" type="ordered locus">BLA_1545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015940210.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1545"/>
    <dbReference type="EnsemblBacteria" id="ACL29827">
        <property type="protein sequence ID" value="ACL29827"/>
        <property type="gene ID" value="BLA_1545"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1545"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1624"/>
    <dbReference type="HOGENOM" id="CLU_031864_5_1_11"/>
    <dbReference type="OMA" id="VDNFPGY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="9"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="320" mass="33868" checksum="7B6612A4BAC9D3B9" modified="2009-03-03" version="1">MNSTATVHNVIIVGSGPAGYTAAIYLARAGLKPVVVAGALTPGGQLINTTEVENYPGFPDGVMGSDLMESMQRQAERFGAEIVFDDVESADLQGELKSVHLSGGQDLQTRTVIVATGSNYRHLNVPGELEYSGKGVSYCATCDGFFFRGKPIVVVGGGDSAMEEANFLARFGSSVTLIHRRDEFRASQIMVERTRENPKINLLMNTVVERINGDGKGVTSLDLRNTATNETSKIEANGVFVAIGHVPQTGFLGGQLDLDDHGYIRIDETSTGATRTSVPGVFAAGDCADAIYQQAIVAAGSGCRAALDVQSYLEDIPEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV20</accession>
    <name>B8DV20_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268887.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28321">
        <property type="protein sequence ID" value="ACL28321"/>
        <property type="gene ID" value="BLA_0016"/>
    </dbReference>
    <dbReference type="GeneID" id="66532392"/>
    <dbReference type="KEGG" id="bla:BLA_0016"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.17"/>
    <dbReference type="HOGENOM" id="CLU_1831223_0_0_11"/>
    <dbReference type="OMA" id="PMAEATK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="141" mass="15844" checksum="794CBC39A2E0A18A" modified="2009-03-03" version="1">MAEATKHTITVDLDMFDKTPEEKTAHANEIAREFGVGEDALAAVEDFKKELTKHNAWDLPFMGYVNEDGYGYAYVPNAAITTTPYWDAHAAFLALPKDAQTAFAIRMLFTHRPVDRYGADMFLHYQRGISTNFIGTGANKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV22</accession>
    <name>B8DV22_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619603.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28323">
        <property type="protein sequence ID" value="ACL28323"/>
        <property type="gene ID" value="BLA_0018"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0018"/>
    <dbReference type="HOGENOM" id="CLU_2191859_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="108" mass="11716" checksum="7B5A480580CBD3FC" modified="2009-03-03" version="1">MGTRCTPQALAGRVNVYNRISPTKAPCGSIRRVASIRITTAHGVQEHTHVTLGGIEQYVQIRGEDRRNPVILWLHGGQCTVPDYSSRSGDGALSAPTAECTRGLYARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV28</accession>
    <name>B8DV28_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zn-ribbon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28329">
        <property type="protein sequence ID" value="ACL28329"/>
        <property type="gene ID" value="BLA_0024"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0024"/>
    <dbReference type="HOGENOM" id="CLU_177539_0_0_11"/>
    <dbReference type="OMA" id="ATRMANM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="104" mass="11542" checksum="FF744EAF34E0B496" modified="2009-03-03" version="1">MGRAVRKSENAKGVPMLFAEPRRATRMANMGDYADMDAENVESAEVVCPRCGSRHVAQILHGMPAFTEELQRELAEGKVVLGGCDIDIFHPTPSYHCNDCEEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV32</accession>
    <name>B8DV32_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BLA_0028</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219064.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0028"/>
    <dbReference type="REBASE" id="19804">
        <property type="entry name" value="M.BanADORF28P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28333">
        <property type="protein sequence ID" value="ACL28333"/>
        <property type="gene ID" value="BLA_0028"/>
    </dbReference>
    <dbReference type="GeneID" id="66532405"/>
    <dbReference type="KEGG" id="bla:BLA_0028"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.28"/>
    <dbReference type="HOGENOM" id="CLU_006958_2_0_11"/>
    <dbReference type="OMA" id="EPFTGAN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031303">
        <property type="entry name" value="C5_meth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00095">
        <property type="entry name" value="C5_MTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0680">Restriction system</keyword>
    <keyword evidence="5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH_17" evidence="9">
        <location>
            <begin position="6"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL28333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="453" mass="51155" checksum="28B0C85735995432" modified="2009-03-03" version="1">MSENALLNTKETAQYIGVSAGVVTRLANTGELEFDTCGARKVFRKEAIDAYLERNNLIQAAVDQVSTKDFEDNICALSFFSGAGGLDLGFERAGISAALYCENNRECRMTLHRNRPDVALLGDITKISADEVRRMARIPQGREIDVMFGGPPCQAFSTAGARRAFEDPRGNVFLRYLDLASELKPRYLVIENVRGLLSTPFPVESGGKPIRGGVMRYILNKLEEMGYGVSFNLYNAANFGAAQIRERVVIIAKRDGTKCDWLIPTHTDPDGKYVQNWNLPSWVTFRDVVYDIEDSRQTHTDFPEKRLLYFSMLKEGQCWNKLPIEIQEEAMGKAYKLGGGKTGFYRRIAWDRPSPTLVTSPTMPATDLCHPKELRPLSVEEYKRVQGFPDDWWIAGSIHDQYRQIGNAVPVSLGEAIGRAILDDMRGEAHDERWRNFPYSRYAHTSDQNWNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV37</accession>
    <name>B8DV37_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619611.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28338">
        <property type="protein sequence ID" value="ACL28338"/>
        <property type="gene ID" value="BLA_0033"/>
    </dbReference>
    <dbReference type="GeneID" id="66533952"/>
    <dbReference type="KEGG" id="bla:BLA_0033"/>
    <dbReference type="HOGENOM" id="CLU_568237_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="480" mass="53922" checksum="1626CB808862C3C2" modified="2009-03-03" version="1">MDTARQFIPMAPVCTVTADQVVHDFQGDIPAGVKFRCPSCDRPVQFHRGSRASTTSADASGDQAPAVRRNPRSHSSRSVHRTVRPHFRHAKNDPVARFCERYQAGLGADPRIIVPSLPMFLRKDRNRAGSGHHAQSTPTFHLEISVRRRSLGHDLISELRKDRATLTVDGISHNLADLVSDRKYTIHLENPSFGLRARISVPEQWQRNVGSPEDGEQAFIFTSEFGPNGGRRLSYGASLHAGFDYYVVARPSILRALQSCFDIAVPIGEINSSHGNLLVVRIVTLWNSLNRTQADFWLADHGFRLTSLDLDPVPVWPPQLRSNGIDEPLFSNSQQIYQTPFASRNENPVHDDIDFPRLNCDHLNPRRVGLLGFAPHGRVRSQIEGECCFLRANRYLPWSAYVLSHTYPEGLMLADAPHLPSSDEQPHASSTALMPELAIKQTQCQTLNKHLDIEQRRLEQPQHHGIPLSVSLARIRSTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV56</accession>
    <name>B8DV56_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_0054</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-01" db="PDB data bank">
            <title>The crystal structure of a LacI-type transcription regulator from Bifidobacterium animalis subsp. lactis DSM 10140.</title>
            <authorList>
                <person name="Tan K."/>
                <person name="Li H."/>
                <person name="Endres M."/>
                <person name="Joachimiak A."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 2-344</scope>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219334.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="PDB" id="5UFH">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.45 A"/>
        <property type="chains" value="A=2-344"/>
    </dbReference>
    <dbReference type="PDBsum" id="5UFH"/>
    <dbReference type="SMR" id="B8DV56"/>
    <dbReference type="STRING" id="442563.BLA_0054"/>
    <dbReference type="EnsemblBacteria" id="ACL28357">
        <property type="protein sequence ID" value="ACL28357"/>
        <property type="gene ID" value="BLA_0054"/>
    </dbReference>
    <dbReference type="GeneID" id="66532430"/>
    <dbReference type="KEGG" id="bla:BLA_0054"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.59"/>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_11"/>
    <dbReference type="OMA" id="LACEYIE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="5UFH"/>
        </source>
    </evidence>
    <sequence length="344" mass="37687" checksum="051C1BC165CD202A" modified="2009-03-03" version="1">MAKGVTIKDVAAEAGVSFKTVSNVINGTGSMRESTRGRVLEAMDKLNYTINLSARSLKTGTTGLLGLAIFDFSQPFASYLADQIIVCAREHHYGVIINTYGQNEHGLARAMRQANNLAADGWIVFADHAMGQHSKMLDQSYPLVLTGDWDAYGKVDQVTMPNVEAMRYTTNRLLDSGYRSIALFGADGSLGARHYRQATEGTQELRVQGYMQAYEEHGIEARMDMLFSGGLLTSDSGVRATNLMMDQGVRPDAIICLNDAMALGALHQLQVRGIRVPDDVQVVGFDNVPEATYANPSLTTIDPHIDSYARHAVDMLIERIQGYDGAKRVYTSDFTLVERSSTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV70</accession>
    <name>B8DV70_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane spanning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BLA_0068</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0068"/>
    <dbReference type="MEROPS" id="S54.A08"/>
    <dbReference type="EnsemblBacteria" id="ACL28371">
        <property type="protein sequence ID" value="ACL28371"/>
        <property type="gene ID" value="BLA_0068"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0068"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.73"/>
    <dbReference type="HOGENOM" id="CLU_055068_2_2_11"/>
    <dbReference type="OMA" id="NVGLFVW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="77"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL28371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="266" mass="29460" checksum="4E934B9B9B900208" modified="2009-03-03" version="1">MPRRGFSLFPDSPSARRIFSAESLRARWRSGEPVVTSAIILVCVAVWLLETLFRFVWPAGLAGMLGFGMMQPASMTREPWTLVTAMFLHQPASLWHIGFNMLTLWSVGPVLERLMGHWAFLILYMVSGIGGDAGMMIWALLNRSGEGWFTSSYGASGALFGLFAAILVVYRKVGQDLTSMIVWMAINFLMPVIVPNIAWQAHVGGFVIGGLFTILMTDGVRALRRRPVLERALIYGAVLLVLLLVVCYACNTANPMRTGSWIPFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV78</accession>
    <name>B8DV78_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pknA</name>
        <name evidence="6" type="ordered locus">BLA_0076</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218368.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0076"/>
    <dbReference type="EnsemblBacteria" id="ACL28379">
        <property type="protein sequence ID" value="ACL28379"/>
        <property type="gene ID" value="BLA_0076"/>
    </dbReference>
    <dbReference type="GeneID" id="66532451"/>
    <dbReference type="KEGG" id="bla:BLA_0076"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_11"/>
    <dbReference type="OMA" id="NVESWEV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="13"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL28379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="341" mass="37573" checksum="4329B4B8DF5B4BF0" modified="2009-03-03" version="1">MRLIEGQLIHCRYRLDSRLAQGGMGEVWKGYDIQLGRPVAIKALRKDTTNQESKLRRLRAEARNSANLAHPNIAALFEYYEHDGIGFLIMEYVPSKSLADLYHELDGPMDPIRLLPILIQTARGLFVAHSHGVIHRDVKPANIMVSDNGEVKITDFGVSYSTNQEQITQDGMVVGTAQYISPEQAQGQQATPQSDIYSLGVVAYEGLCGHRPFTGATPVDIAAAHVNNPVPPLPNTVDFQLSQFVMSMLAKDPADRPQDALTVARVLSRIERRLLDQQTALSDTTMVNINGRVPRRVTSAPHHDLQTYQSAFPFAQQTQRDAGTDSPGHAIAGGFGRSINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV80</accession>
    <name>B8DV80_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein involved in cell wall formation and stabilization of the FtsZ ring during cell division</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rodA</name>
        <name evidence="8" type="ordered locus">BLA_0078</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218375.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0078"/>
    <dbReference type="EnsemblBacteria" id="ACL28381">
        <property type="protein sequence ID" value="ACL28381"/>
        <property type="gene ID" value="BLA_0078"/>
    </dbReference>
    <dbReference type="GeneID" id="66532453"/>
    <dbReference type="KEGG" id="bla:BLA_0078"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.83"/>
    <dbReference type="HOGENOM" id="CLU_029243_3_1_11"/>
    <dbReference type="OMA" id="IFCTVGE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="447"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="479"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="580" mass="62397" checksum="BFE9A80A83086B0A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV85</accession>
    <name>B8DV85_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0083"/>
    <dbReference type="EnsemblBacteria" id="ACL28386">
        <property type="protein sequence ID" value="ACL28386"/>
        <property type="gene ID" value="BLA_0083"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0083"/>
    <dbReference type="HOGENOM" id="CLU_033863_19_0_11"/>
    <dbReference type="OMA" id="RKFPASM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="20"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="172"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="305" mass="33072" checksum="E889810463D33116" modified="2009-03-03" version="1">MSGKGEQTPSFEQTPRKMAIGIACVLIGGTCWGVNGAVSKILMEEYHAAPLWIACVREIIAGIIFLVAAMIGTPHSLRSAVTSWREYPKFVGAALTCVTLVQVAYLFSIHWTNAGTATVLQTVNLLMVLIYVCVRAKRRPTKREVIGVALAFVGVWLLATGGKLSTLSMPLPGLFWGLMDAFSCACLAIIPVGLIARYGNLTFNGLTFLISGLILLPFVKPWQNMPHFDARGWWLMAFTVVVGTVVAFWLFMAGVVRIGSMRATLLATIEPVTATISSVLWTGSVFTPVDIVGFVLILIMSFLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVB2</accession>
    <name>B8DVB2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218408.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28413">
        <property type="protein sequence ID" value="ACL28413"/>
        <property type="gene ID" value="BLA_0110"/>
    </dbReference>
    <dbReference type="GeneID" id="66532485"/>
    <dbReference type="KEGG" id="bla:BLA_0110"/>
    <dbReference type="HOGENOM" id="CLU_2932006_0_0_11"/>
    <dbReference type="OMA" id="GQYFAPW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="60" mass="6694" checksum="6EB7212C6A7CD116" modified="2009-03-03" version="1">MRIRHGHLFTRLAIAAIAALRDAGVSVETHEMNGWPHGFGADGGWIDQYFAPWLTTVFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVB4</accession>
    <name>B8DVB4_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavodoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0112</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0112"/>
    <dbReference type="EnsemblBacteria" id="ACL28415">
        <property type="protein sequence ID" value="ACL28415"/>
        <property type="gene ID" value="BLA_0112"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0112"/>
    <dbReference type="HOGENOM" id="CLU_068890_0_1_11"/>
    <dbReference type="OMA" id="PFVTHGG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12682">
        <property type="entry name" value="Flavodoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867562" description="Flavodoxin-like domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="3">
        <location>
            <begin position="49"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="199" mass="21328" checksum="7A9DC7F8448EFFC8" modified="2009-03-03" version="1">MVLGFSACGSTSGSSSNSSGSSTASNDSGNNTGTSGDTPTVTKGSNGKALIAYFSKTGTTQRAAEEIQKLTGADMFRIEPVQAYPEEYQRTTEIARDELNQNARTQVKGKVDDMAQYDTIFVGYPIWWMEPPMPVLTFLESYDLNGKTVIPFATSASSGIDGTLDMLRSSAKGANVTEGLRVTSNDEIQPWLQKIGVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVC9</accession>
    <name>B8DVC9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Branched-chain amino acid transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">livF</name>
        <name evidence="3" type="ordered locus">BLA_0127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218426.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0127"/>
    <dbReference type="EnsemblBacteria" id="ACL28430">
        <property type="protein sequence ID" value="ACL28430"/>
        <property type="gene ID" value="BLA_0127"/>
    </dbReference>
    <dbReference type="GeneID" id="66532502"/>
    <dbReference type="KEGG" id="bla:BLA_0127"/>
    <dbReference type="HOGENOM" id="CLU_027128_5_0_11"/>
    <dbReference type="OMA" id="YGVGFEQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867563" evidence="1">
        <location>
            <begin position="30"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="47"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="421" mass="43268" checksum="E0F50A5BEA792A2C" modified="2009-03-03" version="1">MRLANKMKMLTAMTAAALLALSGCGSSGGASGGSSNSVASSGDGMVIGALLPLTGTLAYLAPPEVAAIKLAISDINKAGGVLGKDVTEVEADTSDGEHADQNTSAAQSVLSKHPSVVIGPAASGVVKNVYKSIVAEKIPVISMASTSMTLSGMDPYFFRTVAPDAVQGAVMGDLIAQDGVKKLAIACFNDEYGTGMRDIILQKLKDAGVDVVYGEKDAFDPAETNYSSIATAIKNSGADATLIISYDQATPLIKALASAGVDTHKLYLVDGNTVDYSKTYDAGLLKGSKGTIPGTHVDDKFKSDLKGTGTDISDTTYAAETYDAVILAALAAEQGGSTSGETVAKNLSSVSGADGGEKCESFEACKALIKDKKKIQYFGKTGIGPFNKNNDPSSANIGIFEYDGNNVNVFQDMQSGDVPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVD5</accession>
    <name>B8DVD5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative C14orf159-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218436.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0133"/>
    <dbReference type="EnsemblBacteria" id="ACL28436">
        <property type="protein sequence ID" value="ACL28436"/>
        <property type="gene ID" value="BLA_0133"/>
    </dbReference>
    <dbReference type="GeneID" id="66532508"/>
    <dbReference type="KEGG" id="bla:BLA_0133"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.139"/>
    <dbReference type="HOGENOM" id="CLU_062537_1_0_11"/>
    <dbReference type="OMA" id="DVSNWGA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025504">
        <property type="entry name" value="DUF4392"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14336">
        <property type="entry name" value="DUF4392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4392" evidence="1">
        <location>
            <begin position="22"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="319" mass="34180" checksum="F4B4C4E77E952E2B" modified="2009-03-03" version="1">MGSITDWSKYPRISRIATAAAADVGRGSETLMTYVRGDLFRSARHLALGTEQPRRARRENRRKTKRPARALVVTGFYIPQAQQPAAETDGPLGALEVCMALRAVGGDAWLISDEHCAPVICAAAGDLLPEDRVLIAPHAKPEFDAWFNMVIDLVKRHGIDTLVFIERVGPARDGRPRNMRGVDIAEWTAPLSQLALLELHTIGVGDGGNEIGMGRVADYAISGVVAHGESIACTVAADQLVVAGTSNWGAHALVCAMRALGCPQVEPYLEPDWHRAVLDAIVAAGGLDGVHMTNVPTVDGLDPARYFGTVAQLSAFARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVE2</accession>
    <name>B8DVE2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endoglucanase E</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218447.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0140"/>
    <dbReference type="EnsemblBacteria" id="ACL28443">
        <property type="protein sequence ID" value="ACL28443"/>
        <property type="gene ID" value="BLA_0140"/>
    </dbReference>
    <dbReference type="GeneID" id="66532515"/>
    <dbReference type="KEGG" id="bla:BLA_0140"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.148"/>
    <dbReference type="HOGENOM" id="CLU_042506_2_1_11"/>
    <dbReference type="OMA" id="NSWYSYA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040794">
        <property type="entry name" value="CE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17996">
        <property type="entry name" value="CE2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CE2_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="146"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="365" mass="40970" checksum="286C475EF12B34EA" modified="2009-03-03" version="1">MQFIDAFNPAFRTMGRIGESKNHLPLWVFPYTQARFRFTGTSLAVRLRNFWNYGHTRIGVIIDNTQFSVRVPSPVEPEPDAAVSVGEDGMLTIRIASHLPNIEHRAIVFKREDGGMHYMEFAGVEIDDDAQILAPAEPASTRRIEVYGDSVSCGERNEAVLCTGKADPDEDLSAYSNSWFAYDAIAARALGADLRIISQGGAPLLDGIGWFNAPDYLGMESIWDRVQYNPALGEPTDWDFRDDDPQVVIVALGQNDSHPYDFMAADYTGEQAANWRARYAEFLGDLLERYPDAHIICTTTVLQHDRNWDRAIDEVVSELDNPQITHFDYSRAGTGTPGHPRIAEDEEMARELVAYIDSFGAELWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVF2</accession>
    <name>B8DVF2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aromatic amino acid transport protein AroP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroP</name>
        <name evidence="7" type="ordered locus">BLA_0150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218458.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0150"/>
    <dbReference type="EnsemblBacteria" id="ACL28453">
        <property type="protein sequence ID" value="ACL28453"/>
        <property type="gene ID" value="BLA_0150"/>
    </dbReference>
    <dbReference type="GeneID" id="66532524"/>
    <dbReference type="KEGG" id="bla:BLA_0150"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.158"/>
    <dbReference type="HOGENOM" id="CLU_007946_9_3_11"/>
    <dbReference type="OMA" id="VIMYLTP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="6">
        <location>
            <begin position="25"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL28453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="498" mass="53978" checksum="A3229D0D77C33980" modified="2009-03-03" version="1">MSASHGAGERNADPQQLHKSLKNRHIQLIALGGAIGTGLFYGSSESIALAGPSILLAYVIGGAAIFVIVRAMSEMSVEEPKAGAFSYYASRYWSKRAGFISGWNYWFNYVLVSMVELAVVGSFVNYWFPNIPQWASAAFFLVLITLLNLFGVSEFGEFEFWFALIKIVAVIAMIAGGLWVIVANLPTDSGVRASFANWFTVDGGFFPHGAMSRAADGHWDGLLMALVVVMFSFGGTELIGVTAGEVENPSKTIPRATNGIIWRILVFYVAALGIIMAVVPWDRIDGKMSPFVQIFDSVGVPVAAGILNFVCLTAVMSVYNSALYSNSRMLFSLARQGNAPAYLGRVNKRGVPVAGVLTSAAVTVVAVVVVFLWPQFAFNYLMSIATIAAIINWTMIMITEMLFRRRVAAGDGPGELNGLRGAEALAKIRFKLPGWNWTPYVIIAFLAMVAVLMCFSPSYRIALIAGVIWLAVLFAAYAITSRASAKRDAKTVLDSTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVH1</accession>
    <name>B8DVH1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP binding protein of ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_0170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218485.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0170"/>
    <dbReference type="EnsemblBacteria" id="ACL28472">
        <property type="protein sequence ID" value="ACL28472"/>
        <property type="gene ID" value="BLA_0170"/>
    </dbReference>
    <dbReference type="GeneID" id="66532545"/>
    <dbReference type="KEGG" id="bla:BLA_0170"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.179"/>
    <dbReference type="HOGENOM" id="CLU_000604_86_7_11"/>
    <dbReference type="OMA" id="PAADECT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="13"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="290"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="322"/>
            <end position="329"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="495" mass="54290" checksum="60B522CA26200618" modified="2009-03-03" version="1">MNGTRCALDGCSFRYASDESADGVERGVHAIDHVSLQARAGEVVMLVGRSGCGKTTVTRLLNGLAPEYFRGSLHGEARVGGLHAGVAAVEDYATEVGSVFQNPKTQYFHANSTDELAFPCENAGMEPSEIRRRIRERLRAFDVEHLHDRNIVDCSGGQQQQLAVVAATMLDPGVLVLDEPTSNLDAEAMERLRNMVKRLKRDGIAIVIAEHRLAWVADLADRYVVFDAGRVVGEYTAEQFHALPESQRRAWGLRALELSGPRGQVERIAQRAEPSGEKPVIATRGLKVGYERRRLFGRTKRGFVREVGDVNLFAGQIVGLIGRNGAGKSTFVKTVCGLVEPVAGEILVDGRAAKPGRLSALCAMVMQDVNYQLFASSVREEMLLEAMQHVRTAEDAQRVRERADGILRQLGLLDFAERHPMTLSGGQKQRLAIGVALMGEKRVVVLDEPTSGLDRHHMLQVGALMRDLADRGVCVLVVTHDDELAAEVCDRIVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVK7</accession>
    <name>B8DVK7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268986.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0206"/>
    <dbReference type="EnsemblBacteria" id="ACL28508">
        <property type="protein sequence ID" value="ACL28508"/>
        <property type="gene ID" value="BLA_0206"/>
    </dbReference>
    <dbReference type="GeneID" id="66532580"/>
    <dbReference type="KEGG" id="bla:BLA_0206"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.217"/>
    <dbReference type="HOGENOM" id="CLU_085950_0_0_11"/>
    <dbReference type="OMA" id="QDGFEPP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043755">
        <property type="entry name" value="DUF5701"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18959">
        <property type="entry name" value="DUF5701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="209" mass="23140" checksum="FAA2725ADDB2A250" modified="2009-03-03" version="1">MSMASIEANKQLERLVALGYPDVADMSEDAFRALARPLIRALERSDLGADILLVPTRELVTPESLIARTSIDRMAGFTTMPPRDIVSFLPTDGFEPPEGPFYLVIEPHTGTCYTNREPDVARKLIESDERLPLTLEEGLAIATQHPEWLLEKNGFNLLGSRSADGRVPSIWMSQSAPRLGAVWPNSRHTWLGNAYCIARRGVSLIEGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVL4</accession>
    <name>B8DVL4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible DNA polymerase III delta prime subunit</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219307.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0213"/>
    <dbReference type="EnsemblBacteria" id="ACL28515">
        <property type="protein sequence ID" value="ACL28515"/>
        <property type="gene ID" value="BLA_0213"/>
    </dbReference>
    <dbReference type="GeneID" id="66532587"/>
    <dbReference type="KEGG" id="bla:BLA_0213"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.226"/>
    <dbReference type="HOGENOM" id="CLU_006229_4_1_11"/>
    <dbReference type="OMA" id="GFCDGCH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="430" mass="47146" checksum="573208D93E4A2081" modified="2009-03-03" version="1">MSVWDAIVGQPKVVEELRRVAEGDGRGVAQSWLICGPAGSGTMQVARAFAAALESPDHGEGELPTKITSQILADRFPDVVTLSTDKVTIGIDEVRDLVTLSEQMPSTAPWRIIIIENTERMLERTTNVLLKEIEEPSAHTIWLLCAPSAQDVLPTIRSRTRLVTLGVPVADEIATWLEREVRVLEDPTKRERARAKAVGGRAGAKAARSGKSAKAPKPAPAPEPRPVSHETAVRIARLCEGNLDIARLYARYPSVLRSRDQLVNNVLKMTRASQAVVFAGELYGSAQEQANERAEQAAGERQAEFRKLNGLSPDETVPADLRRAYTALAKKDDIKRHATRMTRDVLDRAFTTIASIYRDVAVFQNDAEGSVGLINIENRDAIAELSAQLTREQTLARMDAISTARRRIAGNGNALLDIEALFCALLPERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVQ9</accession>
    <name>B8DVQ9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cation efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_0258</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0258"/>
    <dbReference type="EnsemblBacteria" id="ACL28560">
        <property type="protein sequence ID" value="ACL28560"/>
        <property type="gene ID" value="BLA_0258"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0258"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.273"/>
    <dbReference type="HOGENOM" id="CLU_056154_2_0_11"/>
    <dbReference type="OMA" id="GWATFYL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL28560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="301" mass="33183" checksum="49C4186DDB4F5021" modified="2009-03-03" version="1">MHQKKIEQQALKVGIVVNIVMVLAGFFVFFLTGLKSMFLDASFTVISVISGGVAAYLSKKTVRVSDRFPNGMFALEPIYAICKSIFTICLLLFSFLDVAQIAIAYFVHGEGERLEFGPVIIYQILAVAVCIALVAYYRARNRTLGNASLMLKAEANGTWIDGMISLGIGIVAVLLYFLPNGTPLDFLHYTGDFFITTIIVALTIKEPVTVLRDAFVELIGGTHDDEEVSELVSREASAHLPAGVKVQTIHVFKTGMNFDIDIIVNGTGDVVRVEDLVEARKRMERALEPKLHLVNVDFVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVS3</accession>
    <name>B8DVS3_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="4 8">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BLA_0272</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="4 8"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619684.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0272"/>
    <dbReference type="EnsemblBacteria" id="ACL28574">
        <property type="protein sequence ID" value="ACL28574"/>
        <property type="gene ID" value="BLA_0272"/>
    </dbReference>
    <dbReference type="GeneID" id="66532647"/>
    <dbReference type="KEGG" id="bla:BLA_0272"/>
    <dbReference type="HOGENOM" id="CLU_025154_3_0_11"/>
    <dbReference type="OMA" id="VYFPGSP"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="PTHR11098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAPRTase_N" evidence="10">
        <location>
            <begin position="54"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="NAPRTase" evidence="9">
        <location>
            <begin position="199"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL28574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="486" mass="52281" checksum="137DCC85960E23CD" modified="2009-03-03" version="1">MTSAHICALIRLGWGTTTSARGESTAAPANREEITQEKRTANTGDTMVVYDPSLMTDMYEYTMLDATLQDGTANRPCVFEVFTRHLPEGRRYGVVAGIGRLLDALEDFHLDDADLKFLSDRHIVSRGTVKWLENYHFTGSIRGYREGEVYFPNSPILQVRGSFGECTLLETLILSILNYDSAVAAAASRMVTAAKNRPCMDMGGRRTNEWAAVAAARASIVGGFKGTANLLAAKLYDLPAIGTAAHCFTLVHDSERQAFESQIAALGTNTTLLVDTYNIEEAVKTAVEVAGPNLGGVRIDSGDLAALAQRVRNQLDALGATNTKITVTNDLDEYAIASLQTAPVDSYGVGTQLVTGSGAPTCAMVYKLTERANNAGHMEPVAKKSVDKATAPGAKLAFRSYEYSLADCEHVISGSESALENFVPGEGWEDLLTDFVVNGTVDPQFQGHDGLMAAQDYHAKALAKLPITAQSLMRGEPVIPTKLEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVU3</accession>
    <name>B8DVU3_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aspC</name>
        <name evidence="3" type="ordered locus">BLA_0292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268429.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0292"/>
    <dbReference type="EnsemblBacteria" id="ACL28594">
        <property type="protein sequence ID" value="ACL28594"/>
        <property type="gene ID" value="BLA_0292"/>
    </dbReference>
    <dbReference type="GeneID" id="66532669"/>
    <dbReference type="KEGG" id="bla:BLA_0292"/>
    <dbReference type="HOGENOM" id="CLU_017584_4_3_11"/>
    <dbReference type="OMA" id="APYWTTY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="38"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="405" mass="43651" checksum="B0B80CEA63980FFA" modified="2009-03-03" version="1">MPTDQTRLPLSNRIDKVAPSATLAVDMKAKAMKAQGIDIIGFGVGEPNFATPEAIVEAAAAAVVNPANYKYSPTPGLPELRQAIASKTLRDSGYEVEPEQVVVTNGGKQAVYEAFQLIVNDGDEVIIPSPYWTSYPEMVKLAGGKPVEVFAGADVNYEPNLDDIEAARTDRTKAIIVTSPNNPTGAVWSERTIRDIAEWALDHNIWVISDEIYEHLTYDGVKTTHIGAAVPQIREQLIVLDGVAKTYAMPGWRVGWMVAPLAVAKAASKLQGHMTSNVNNIAQRAAIEAVSGPLDAVAMMRDAFNVRRLAIVAALNDINGVHCPMPEGAFYAFPNVEGLLNRPMGPNGTTFTTSAELAEALLEEGHVAAVPGEAFGAPGYMRFSYAVADEEITEGMRRFKEWAEA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVV4</accession>
    <name>ACPS_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Holo-[acyl-carrier-protein] synthase</fullName>
            <shortName evidence="1">Holo-ACP synthase</shortName>
            <ecNumber evidence="1">2.7.8.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">4'-phosphopantetheinyl transferase AcpS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">acpS</name>
        <name type="ordered locus">BLA_0303</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>apo-[ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="EC" id="2.7.8.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the P-Pant transferase superfamily. AcpS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DVV4"/>
    <dbReference type="SMR" id="B8DVV4"/>
    <dbReference type="STRING" id="442563.BLA_0303"/>
    <dbReference type="EnsemblBacteria" id="ACL28605">
        <property type="protein sequence ID" value="ACL28605"/>
        <property type="gene ID" value="BLA_0303"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0303"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.325"/>
    <dbReference type="HOGENOM" id="CLU_089696_2_0_11"/>
    <dbReference type="OMA" id="NTCGLGH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000118794" description="Holo-[acyl-carrier-protein] synthase">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00101"/>
        </source>
    </evidence>
    <sequence length="147" mass="15978" checksum="0FC41AB8C64287EC" modified="2009-03-03" version="1">MLGLGHDVVDVGAFAEQLEMPGTRMTRLFSARECRQASLRASIKHDGEALHLAAKWAAKESVVKAWCEALVGRGITERPYTVDDTPWSRIEIVDDATGCPRVVMAAEVHVELCRSLAVTESAEPVWHVSISHDGGIASAVAVLDMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVW5</accession>
    <name>B8DVW5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible oxidoreductase of the aldo/keto reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268479.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0314"/>
    <dbReference type="EnsemblBacteria" id="ACL28616">
        <property type="protein sequence ID" value="ACL28616"/>
        <property type="gene ID" value="BLA_0314"/>
    </dbReference>
    <dbReference type="GeneID" id="66532693"/>
    <dbReference type="KEGG" id="bla:BLA_0314"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.336"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_11"/>
    <dbReference type="OMA" id="RRMLPKY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="287" mass="31493" checksum="0C3666B6C00EC98A" modified="2009-03-03" version="1">MVLHRNLGPFDTTAIGLGEMPLTIENNLGPKMGVETIHAALDAGCRQIDTAWAYYCSGGEEQTGEKLVREALASWDGPRDEVLVATKVGHFRNFTDGKPTWDVDGSPENLIKRAKQSAFELGVDMIDLLYFHRPDPKIPYGESCEAMKEIRSMGIAREIGISNASIEQIDIAREILGDSLIAVQNQFSPIYTETADTLDYCGKVGLSFVCWSPLGGFRKPKDESKFDPFREVAEAHGVSYQQVVLAWELAKGSHVFVIPGAHRPATILDSLKAGDLELTPEELAKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVX1</accession>
    <name>B8DVX1_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminopeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pepC</name>
        <name evidence="3" type="ordered locus">BLA_0320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268489.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28622">
        <property type="protein sequence ID" value="ACL28622"/>
        <property type="gene ID" value="BLA_0320"/>
    </dbReference>
    <dbReference type="GeneID" id="66532699"/>
    <dbReference type="KEGG" id="bla:BLA_0320"/>
    <dbReference type="HOGENOM" id="CLU_038600_0_1_11"/>
    <dbReference type="OMA" id="WDMIVNL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00585">
        <property type="entry name" value="Peptidase_C1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004134">
        <property type="entry name" value="Peptidase_C1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363">
        <property type="entry name" value="PTHR10363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03051">
        <property type="entry name" value="Peptidase_C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005700">
        <property type="entry name" value="PepC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0788">Thiol protease</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR005700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005700-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="446" mass="51086" checksum="4DA35664EE127F87" modified="2009-03-03" version="1">MSDKISPLSSHDLDDLTSEFEGSKSNVMAMNAVTAAGINKVARNYDRARLLQRRFSTSLDNGEATHQDRSGRCWLFSSLNVARYVAKKTMNIKEFEFSQNYAMYFDKLERVNYFLQDIANLIREGEPTDSRLFQHMLHDVMGDGGQWTMAMNVYKKYGAVPKDLYPETESSKNTGELDTQLRRMLHTAVSQMEKSPEHIDEIILQATKAGHRILTIHLGEPPKSFDWEWTDKDGEFHRVGEITPVEFWNRYVGDADLESYVCLVDDPRHEHAKGKKIGIEHLNNVAGGDPTEYLNVPIQFMKDCARDVLVEQGIPVWFGADCHPMMDREDGAWATDLFEYGKVYDYDFTMDKEERVRFADSAMNHAMAFVGVDVADDNKTTRRWRVENSWGTKIADKGYFTMGDDWFDQYVFEVAVPKALLPDEYLKALDEPAQMLPAWDPMGALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVX8</accession>
    <name>B8DVX8_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate-binding protein PstS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pstS</name>
        <name evidence="6" type="ordered locus">BLA_0327</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Part of the ABC transporter complex PstSACB involved in phosphate import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PstS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268505.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0327"/>
    <dbReference type="EnsemblBacteria" id="ACL28629">
        <property type="protein sequence ID" value="ACL28629"/>
        <property type="gene ID" value="BLA_0327"/>
    </dbReference>
    <dbReference type="GeneID" id="66532706"/>
    <dbReference type="KEGG" id="bla:BLA_0327"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.351"/>
    <dbReference type="HOGENOM" id="CLU_034528_0_0_11"/>
    <dbReference type="OMA" id="NAMDLWV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005673">
        <property type="entry name" value="ABC_phos-bd_PstS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002756">
        <property type="entry name" value="PstS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870830" description="Phosphate-binding protein PstS" evidence="4">
        <location>
            <begin position="27"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="5">
        <location>
            <begin position="39"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL28629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="371" mass="38490" checksum="1C669235733F2D8D" modified="2009-03-03" version="1">MRSNLARRVLAALCGMAFIATTTACGDNTDPANRPVANASSISGSFAGAGASSQQTAVEAWVAGYQKTNPDARISYNPSGSGAGVATFLTGATVWAASDKPLDAKQVEESTSVCAGASAFDVPVYISPLAIVFNLQGVSDAGKHINMDAATIAKVFDGRITRWNDAELTAQNPGLSLPDLPITVVHRSDKSGTTLNFLEYIKAAAPADWPYELSENWPNDVGQGAKGTSGVISTIDQANGTIGYADFSQAGGMGTVAVQVGDTPTVISAEAASKAVADSTLDKSVPGKHRVVLDINHTTRVTGAYPIVLVSYDIACPAYTDANTARFAKSWLSYVTSEEGQAQAMNATGSAPLPANIAKYVRESIDAMEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVY6</accession>
    <name>B8DVY6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PT repeat family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619698.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0335"/>
    <dbReference type="EnsemblBacteria" id="ACL28637">
        <property type="protein sequence ID" value="ACL28637"/>
        <property type="gene ID" value="BLA_0335"/>
    </dbReference>
    <dbReference type="GeneID" id="66532714"/>
    <dbReference type="KEGG" id="bla:BLA_0335"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.360"/>
    <dbReference type="HOGENOM" id="CLU_026080_0_0_11"/>
    <dbReference type="OMA" id="RWMITVG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="29"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="543" mass="58495" checksum="2DA88A8760C6E1DC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVZ7</accession>
    <name>B8DVZ7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Possible cationic amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BLA_0346</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619704.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0346"/>
    <dbReference type="EnsemblBacteria" id="ACL28648">
        <property type="protein sequence ID" value="ACL28648"/>
        <property type="gene ID" value="BLA_0346"/>
    </dbReference>
    <dbReference type="GeneID" id="66532728"/>
    <dbReference type="KEGG" id="bla:BLA_0346"/>
    <dbReference type="HOGENOM" id="CLU_007946_15_7_11"/>
    <dbReference type="OMA" id="VIAKYWG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="510"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL28648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="534" mass="57411" checksum="9E94DFA763322E92" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW33</accession>
    <name>B8DW33_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">secY</name>
        <name evidence="11" type="ordered locus">BLA_0382</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268607.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0382"/>
    <dbReference type="EnsemblBacteria" id="ACL28684">
        <property type="protein sequence ID" value="ACL28684"/>
        <property type="gene ID" value="BLA_0382"/>
    </dbReference>
    <dbReference type="GeneID" id="66532765"/>
    <dbReference type="KEGG" id="bla:BLA_0382"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.409"/>
    <dbReference type="HOGENOM" id="CLU_030313_0_0_11"/>
    <dbReference type="OMA" id="FAMWLGE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL28684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="449" mass="49893" checksum="25CEFA6E4DE1E5FB" modified="2009-03-03" version="1">MRTLIQAFRTKELRNKILFVLGIIIIYRIGSFIPTPGVDYKVVNDCVANTTNNAENFIGLVNLFSGGAMLQLSIFALGVMPYITASIVVQLLRAVIPRFEALHKEGQSGEAKLTQYTRYLTIGLAVLQSTTILVTARSGALFNYQCNNVIPDASIWNMVVMIMVMTGGTGLIMWMAELITEKGIGQGMSILIFLSICSGFLPQLWQIGWGTNGTDGNWTKFAIVTVVLLVIMIFVNYVELSQRRIPVQYTRRMIGRKMYGGSSTYLPLKINMSGVIPPIFASSILAIPTLFAQFGNSQQSWVQWVNKYLANTTSVWYICLYALMIVFFTFFYTEITFNPDETADNMKQFGGFIPGIRAGSATSRYLKYVINRLNTVGAIYLLFVALLPTVLIMALKLNTQLPFGGTTLLIIAGVGLDTLRQAKAQTEQYQYAGFLFENTDHTEGKAIAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW40</accession>
    <name>TRUA_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="1">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">truA</name>
        <name type="ordered locus">BLA_0389</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619707.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DW40"/>
    <dbReference type="SMR" id="B8DW40"/>
    <dbReference type="STRING" id="442563.BLA_0389"/>
    <dbReference type="EnsemblBacteria" id="ACL28691">
        <property type="protein sequence ID" value="ACL28691"/>
        <property type="gene ID" value="BLA_0389"/>
    </dbReference>
    <dbReference type="GeneID" id="66532772"/>
    <dbReference type="KEGG" id="bla:BLA_0389"/>
    <dbReference type="HOGENOM" id="CLU_014673_0_2_11"/>
    <dbReference type="OMA" id="FLYGMVR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_1000194529" description="tRNA pseudouridine synthase A">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <sequence length="298" mass="32607" checksum="D0D17A98048BFF60" modified="2009-03-03" version="1">MTRLRIDLAYNGAAFHGWAAQPGCRTVQGTVEEALRRITRMPDAGSLRLTVAGRTDAGVHATHQVCHVDVPDQTLGQCVGHMNLTPVQALQTRLSRMMPDDIAIHGISVAPAGFDARFSALERTYVYRIADARVPWDPRLKDFAWRTDRELDIAQMNAAAALTLGLHDFGSFAIANPGGTTIREVKTAYWQRVPTRPLLGPGMGERYHTPAVESGLLCFTIVADAFARNMVRSLVGACVQVGMGKRDVDWFAGKMRVPLREGSTGPIAPQGLTLEHIAYPADDELAARAERIRAKRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW55</accession>
    <name>B8DW55_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dipeptidyl aminopeptidases/acylaminoacyl-peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619709.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0404"/>
    <dbReference type="EnsemblBacteria" id="ACL28706">
        <property type="protein sequence ID" value="ACL28706"/>
        <property type="gene ID" value="BLA_0404"/>
    </dbReference>
    <dbReference type="GeneID" id="66532788"/>
    <dbReference type="KEGG" id="bla:BLA_0404"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.432"/>
    <dbReference type="HOGENOM" id="CLU_038552_0_0_11"/>
    <dbReference type="OMA" id="PACLFIH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="515" mass="55901" checksum="62BF3D1C20C7D516" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW61</accession>
    <name>B8DW61_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268670.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28712">
        <property type="protein sequence ID" value="ACL28712"/>
        <property type="gene ID" value="BLA_0410"/>
    </dbReference>
    <dbReference type="GeneID" id="66532794"/>
    <dbReference type="KEGG" id="bla:BLA_0410"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.438"/>
    <dbReference type="HOGENOM" id="CLU_1286694_0_0_11"/>
    <dbReference type="OMA" id="TIPMQVT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="214" mass="22170" checksum="FED113EED489B898" modified="2009-03-03" version="1">MKKQSDSNDAQTPYDDEATEVFAAEGPLDETVGIDERVDLTSTTQMPAADATAPVDMNAPLYAQFAGDTDADSGLGNDGGSDDGGANASSAEPGGEPVGDDLTIPMQTTDASHQASTGEGAPRNIPLYQAPPQCKPEPERPKGASAGTIVFGVVVLLFGALTVTVGLLMNSSMFSFVEFNRITGYLFAGLGILLSLIAIVMGVSSHWRNKNRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW68</accession>
    <name>B8DW68_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase C45, acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_0417</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0417"/>
    <dbReference type="EnsemblBacteria" id="ACL28719">
        <property type="protein sequence ID" value="ACL28719"/>
        <property type="gene ID" value="BLA_0417"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0417"/>
    <dbReference type="HOGENOM" id="CLU_034532_0_0_11"/>
    <dbReference type="OMA" id="CSAFIAT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007000">
        <property type="entry name" value="PLipase_B-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04916">
        <property type="entry name" value="Phospholip_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867657" evidence="4">
        <location>
            <begin position="22"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="470" mass="53042" checksum="3BDA293CE3B2F2D2" modified="2009-03-03" version="1">MRPRLRLPMLLLSSNKGDAMALTSEQQQIVDKATLTRINGWQYLTVEGSPYEIGFEHGYLLTDEFKDAIRVYTHMTLETLGMDYSFFVDQAVKLHKDKIPQEYIEEMQGMADGFTAGGFETSLDDVIGWNDWMELTGYWWPQVAAEYSNNPPDGPKGSHCSGFVATGSATKDGKPVIAHESFDDFWSGQYFNVCESVKPAHGNSFKMQTVPGYIDSMTDFYVTSAGLAITETTIAGFVGYDVDGIPEFVRARKATQYANSIDEWVTIVNEGNNGGYANIWLLADANTNEIARYEQGLKHQELLRTKDGSFYGCNACHNPRIRNLECVDNGYNDTRQQTGARRARFEQLLPQLHGTIDDDVAKRILADKFDPYLGYVNASSRNICAHYDVDPQYYADDPHGVWNVPFFPGGSCDGKCANGDDIKALHMWGIFGRADGEPFDADEFMRQHPQWSWQKGYLYDRPSQPWTLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW70</accession>
    <name>B8DW70_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BLA_0419</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268688.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0419"/>
    <dbReference type="EnsemblBacteria" id="ACL28721">
        <property type="protein sequence ID" value="ACL28721"/>
        <property type="gene ID" value="BLA_0419"/>
    </dbReference>
    <dbReference type="GeneID" id="66532803"/>
    <dbReference type="KEGG" id="bla:BLA_0419"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.447"/>
    <dbReference type="HOGENOM" id="CLU_020854_4_1_11"/>
    <dbReference type="OMA" id="RIEPSRW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="650"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="650"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL28721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="707" mass="76507" checksum="8D120B9602A7518C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW79</accession>
    <name>B8DW79_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoserine transaminase</fullName>
            <ecNumber evidence="6">2.6.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphohydroxythreonine aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BLA_0429</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + 4-(phosphooxy)-L-threonine = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + O-phospho-L-serine = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="6"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619719.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0429"/>
    <dbReference type="EnsemblBacteria" id="ACL28730">
        <property type="protein sequence ID" value="ACL28730"/>
        <property type="gene ID" value="BLA_0429"/>
    </dbReference>
    <dbReference type="GeneID" id="66532814"/>
    <dbReference type="KEGG" id="bla:BLA_0429"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.458"/>
    <dbReference type="HOGENOM" id="CLU_061974_0_0_11"/>
    <dbReference type="OMA" id="TAFWDIA"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006272">
        <property type="entry name" value="Pser_aminoTfrase_mycobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01366">
        <property type="entry name" value="serC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="9">
        <location>
            <begin position="136"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL28730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="379" mass="40633" checksum="47443BA71D0078D3" modified="2009-03-03" version="1">MSTITIPQNMLPADGRFGSGPTKIRREQILDLTNAADTLLGTSHRQRPVKQLVESIREGLAEFFSLPAGYEVVLGNGGASAFWDVVCCSLVSRKAACGVYGSFTKKMAASLSSAPFLEEPAIYEGDFGTWRLPELTDGVDAYCWAQNETSTGVAAPVKRIAGSVNQGALTIIDATSGAGALPVDLSQTDAYYFSPQKAFGSEGGLWVAILSPEAIERAEAVKENAAVPGSIRWIPPFLSLTSAISNSRKNQTLNTPAISTLVLMESQIRYLNGNGGLDWAVKRCERSANTVYSWAEASRYASPYVVDEEARSHAVVTVDLIDAVPAAAVLEALRDNGIVDVNGYRALGRNQLRIGVFPSVDPSDVEALTHCIDYVIEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW84</accession>
    <name>B8DW84_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 5">Thymidylate synthase</fullName>
            <shortName evidence="5">TS</shortName>
            <shortName evidence="5">TSase</shortName>
            <ecNumber evidence="1 5">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">thyA</name>
        <name evidence="8" type="ordered locus">BLA_0434</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="1 5"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0434"/>
    <dbReference type="EnsemblBacteria" id="ACL28735">
        <property type="protein sequence ID" value="ACL28735"/>
        <property type="gene ID" value="BLA_0434"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0434"/>
    <dbReference type="HOGENOM" id="CLU_021669_0_0_11"/>
    <dbReference type="OMA" id="KQYLDLC"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="PTHR11548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="SSF55831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylat_synt" evidence="7">
        <location>
            <begin position="3"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="129"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="169"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="210"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="266" mass="30801" checksum="BCB4A9048584BE4B" modified="2009-03-03" version="1">MPYEDLLRKILMEGNLKNDRTGTGTISLFGQQMRFDLAKGFPLLTTKRVFFKGIAYELLWFLKGSSNVHWLQEHNVHIWDEWADENGDLGPVYGVQWRSWPAPTADDPDRTIDQISNVLELIKHNPDSRRMVVTAWNPAEVENMALPPCHALFQFYVADGRLSCQLYQRSCDMFLGVPFNIASYSLLTMMMAQQAGLEPGEFVWTGGDCHIYDNHVEQVLEQLSREPYPYPRMEIRKADSLFDYQYSNFHIADYRYHPTIKAPIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW96</accession>
    <name>B8DW96_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268756.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0446"/>
    <dbReference type="EnsemblBacteria" id="ACL28747">
        <property type="protein sequence ID" value="ACL28747"/>
        <property type="gene ID" value="BLA_0446"/>
    </dbReference>
    <dbReference type="GeneID" id="66532831"/>
    <dbReference type="KEGG" id="bla:BLA_0446"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.476"/>
    <dbReference type="HOGENOM" id="CLU_547097_0_0_11"/>
    <dbReference type="OMA" id="AWGGPHY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021804">
        <property type="entry name" value="DUF3375"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11855">
        <property type="entry name" value="DUF3375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="524" mass="59087" checksum="FBF63877F9B38FFA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-06-17" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWA1</accession>
    <name>B8DWA1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative uroporphyrin-III C-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28752">
        <property type="protein sequence ID" value="ACL28752"/>
        <property type="gene ID" value="BLA_0451"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0451"/>
    <dbReference type="HOGENOM" id="CLU_137928_0_0_11"/>
    <dbReference type="OMA" id="AHPEHWW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="118" mass="13849" checksum="A42B1C12D44DC918" modified="2009-03-03" version="1">MIQLKRAYAPAEPDDGYRILVDRLWPRGMSKAKEHLDLWMKQIAPSTDLRKAWNHNPNTILEFAESYRRELDANPAVEQLEQILADHPVVTFVYGARDPLVNHARILRDYVEERQKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWA9</accession>
    <name>B8DWA9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable solute binding protein of ABC transporter system for sugars</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_0461</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2019" name="J. Biol. Chem." volume="294" first="11701" last="11711">
            <title>Substrate preference of an ABC importer corresponds to selective growth on beta-(1,6)-galactosides in &lt;i&gt;Bifidobacterium animalis&lt;/i&gt; subsp. &lt;i&gt;lactis&lt;/i&gt;.</title>
            <authorList>
                <person name="Theilmann M.C."/>
                <person name="Fredslund F."/>
                <person name="Svensson B."/>
                <person name="Lo Leggio L."/>
                <person name="Abou Hachem M."/>
            </authorList>
            <dbReference type="PubMed" id="31186348"/>
            <dbReference type="DOI" id="10.1074/jbc.RA119.008843"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.39 ANGSTROMS) OF 28-453</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PDB" id="6H0H">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.39 A"/>
        <property type="chains" value="A/B=28-453"/>
    </dbReference>
    <dbReference type="PDBsum" id="6H0H"/>
    <dbReference type="SMR" id="B8DWA9"/>
    <dbReference type="STRING" id="442563.BLA_0461"/>
    <dbReference type="EnsemblBacteria" id="ACL28760">
        <property type="protein sequence ID" value="ACL28760"/>
        <property type="gene ID" value="BLA_0461"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0461"/>
    <dbReference type="HOGENOM" id="CLU_031285_2_0_11"/>
    <dbReference type="OMA" id="ARIWDEN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006061">
        <property type="entry name" value="SBP_1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01037">
        <property type="entry name" value="SBP_BACTERIAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870934" evidence="4">
        <location>
            <begin position="28"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="6H0H"/>
        </source>
    </evidence>
    <sequence length="453" mass="49235" checksum="6AD399840C491F48" modified="2009-03-03" version="1">MEKGRTMKFSTRAIAFLGATAMLIPLAACGGGSSNSGQPSQESNVKEIDVWAWDPSLKQIAADYEKKTGIKVNLKNVGTNTKEYTQLDNAIEAGSGAPDVAQIEYYALPQYAIKGNLLDITDKTSGYEDFYNPGPWSSVQIDGKVYALPIDAGPMAFFYNKEIFDKAGVDGEKIKTWDDYYEAAKKIHALGDEYYITSDSGDAGFFDSMTWLAGGKPFQTTNNGKDVTINLTGDNGVKEFEKFWQKLLDEKLLDTKTVGWSEDWFKGMQDGTIASLLTGAWMPGNLVNSAPAAAGKWRVALMPTPNGEKANAENGGSSLAVLKSSPKAQAAYDFIEYVAHGDGVKTHVETGAFPADKASLEADYFKNATTIKNSDGKEIDYFGGQKYNEVLAQASADVLTGYQFLPFEVKARGVFGDYLGKSYTGNQPLSEGVAAWQKALIDYGKEQGFTMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWB3</accession>
    <name>B8DWB3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable LacI-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_0465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0465"/>
    <dbReference type="EnsemblBacteria" id="ACL28764">
        <property type="protein sequence ID" value="ACL28764"/>
        <property type="gene ID" value="BLA_0465"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0465"/>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_11"/>
    <dbReference type="OMA" id="SHCVWSD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="338" mass="36635" checksum="786591AE4307D54E" modified="2009-03-03" version="1">MAGSVSMKDVARLAGVSSQTVSRVANNSSEVKPETRLRVERAMEELGYRPNYAARALKHGSFKDVGVVLFNMTSYGDSHILNGVVDAAREHGYATTIRSFEQGCPATLQSAIDQMKTLPVDGVVFILEQQVADFNTFVPSVELPVVLVSEEPSDHCPTIDSDQYGTSVVLVDYLLAKGHRNVYHIAGPSYSVAAQSRRRGWEDALRQQGIVPPSVYIGDWEADSGYQAGLALAHERDCTAVYAANDQMAYGCILGLREAGKRVPEDVSVVGVDDSLQGIVPRLELTTMREKFNELGREAFGMILAQCNGDKLPVGVKTVIPSVLVERGSVSEVEDRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWJ6</accession>
    <name>B8DWJ6_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">DNA-directed RNA polymerase subunit beta</fullName>
            <shortName evidence="6">RNAP subunit beta</shortName>
            <ecNumber evidence="6 8">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">RNA polymerase subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Transcriptase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 16" type="primary">rpoB</name>
        <name evidence="16" type="ordered locus">BLA_0548</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="6 8"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218271.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0548"/>
    <dbReference type="EnsemblBacteria" id="ACL28847">
        <property type="protein sequence ID" value="ACL28847"/>
        <property type="gene ID" value="BLA_0548"/>
    </dbReference>
    <dbReference type="GeneID" id="66533678"/>
    <dbReference type="KEGG" id="bla:BLA_0548"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.577"/>
    <dbReference type="HOGENOM" id="CLU_000524_4_1_11"/>
    <dbReference type="OMA" id="FMTWEGY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01321">
        <property type="entry name" value="RNApol_bact_RpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042107">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_ext_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019462">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_external_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010243">
        <property type="entry name" value="RNA_pol_bsu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10385">
        <property type="entry name" value="RNA_pol_Rpb2_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02013">
        <property type="entry name" value="rpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb2_1" evidence="13">
        <location>
            <begin position="43"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="12">
        <location>
            <begin position="176"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_3" evidence="14">
        <location>
            <begin position="434"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_45" evidence="15">
        <location>
            <begin position="512"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_6" evidence="10">
        <location>
            <begin position="640"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_7" evidence="11">
        <location>
            <begin position="1065"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1149"/>
            <end position="1186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF10385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ACL28847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="1186" mass="131762" checksum="F4DCA8090C9A9EA2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWK1</accession>
    <name>B8DWK1_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0237 protein BLA_0553</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0237 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218277.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0553"/>
    <dbReference type="EnsemblBacteria" id="ACL28852">
        <property type="protein sequence ID" value="ACL28852"/>
        <property type="gene ID" value="BLA_0553"/>
    </dbReference>
    <dbReference type="GeneID" id="66533683"/>
    <dbReference type="KEGG" id="bla:BLA_0553"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.583"/>
    <dbReference type="HOGENOM" id="CLU_155669_0_1_11"/>
    <dbReference type="OMA" id="MIMLVDI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd04872">
        <property type="entry name" value="ACT_1ZPV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01054">
        <property type="entry name" value="UPF0237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022986">
        <property type="entry name" value="UPF0237_ACT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="90" mass="10250" checksum="CD6AB9142165E62E" modified="2009-03-03" version="1">MNKAIITVVGQDTVGIIARVCTYLSDHHTNVLDISQTIIDGFFNMMMIVDYADADVSFETIVNDLEELGEEIGVRIRCQREEIFTKMHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWL6</accession>
    <name>B8DWL6_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">gcvH</name>
        <name evidence="6" type="ordered locus">BLA_0570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="3">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218302.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0570"/>
    <dbReference type="EnsemblBacteria" id="ACL28867">
        <property type="protein sequence ID" value="ACL28867"/>
        <property type="gene ID" value="BLA_0570"/>
    </dbReference>
    <dbReference type="GeneID" id="66533698"/>
    <dbReference type="KEGG" id="bla:BLA_0570"/>
    <dbReference type="HOGENOM" id="CLU_097408_2_2_11"/>
    <dbReference type="OMA" id="EHEWLSG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="32"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3 4">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL28867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="136" mass="14936" checksum="4E17742B3C3D71A0" modified="2009-03-03" version="1">MAEENEQGTHLDVPDFLQYSHDHVWVDESVTPAVLGITEFAANKMGDIVFVDLPEVGMRVEAGDELVQIESAKAVEPMISPVAGVVRYVNSETEDDGAVINDDPYGEGWIVKIELDDDEPDLLSAGEYAKFIAQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWN9</accession>
    <name>B8DWN9_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">BLA_0593</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218325.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0593"/>
    <dbReference type="EnsemblBacteria" id="ACL28890">
        <property type="protein sequence ID" value="ACL28890"/>
        <property type="gene ID" value="BLA_0593"/>
    </dbReference>
    <dbReference type="GeneID" id="66533721"/>
    <dbReference type="KEGG" id="bla:BLA_0593"/>
    <dbReference type="HOGENOM" id="CLU_023810_2_0_11"/>
    <dbReference type="OMA" id="EDFTRPD"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870943" description="UDP-glucose 6-dehydrogenase" evidence="11">
        <location>
            <begin position="28"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="12">
        <location>
            <begin position="326"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="147"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="264"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACL28890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="415" mass="45730" checksum="5C6BA8CD88CC0608" modified="2009-03-03" version="1">MKIAVAGTGYVGLSVALLLSQHNEVHALDIVPEKVELLNNCQSPIVDTEITRFLDGKRDGTMDLDFQATLDPAVAYTGADYAVVATPTNYDSKKNYFDTSSVEAAIKAIREYDPDCWIVIKSTIPVGYTAQLREKTGDKKIIFSPEFLREGHALYDNLHPSRIVVGAPTDDAEAVKAAQTFAMLLAEGAAPEENDRLNADGSTGIPELVCGTTEAEAIKLFANTYLALRVAYFNELDTYAESRGLNTAEIIRGVCLDPRIGTHYNNPSFGYGGYCLPKDSKQLLANYADVPQNLIGAIVESNRTRKDFIADQILSKLEGVEKPVVGIYRLTMKSGSDNFRQSSIQGIMKRIKAKGIDVLVYEPTLDDAEFFGSEVTHDLNAFKNRSDIIVANRWNESDLADAADKVYTRDLFRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWP4</accession>
    <name>B8DWP4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">H(+)-stimulated manganese uptake system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mntH</name>
        <name evidence="5" type="ordered locus">BLA_0598</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0598"/>
    <dbReference type="EnsemblBacteria" id="ACL28895">
        <property type="protein sequence ID" value="ACL28895"/>
        <property type="gene ID" value="BLA_0598"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0598"/>
    <dbReference type="HOGENOM" id="CLU_020088_2_0_11"/>
    <dbReference type="OMA" id="IATFVNS"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="PTHR11706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="135"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="438" mass="45643" checksum="777563354391A09E" modified="2009-03-03" version="1">MVSGEPVVDIDTVAEAAVADQDVAIARKDSGKPEKPIHALASMLGPAFIAAVAYVDPGNVAANLTSGAQYGYLLVWVLVLANCMAVLIQYQASKLGIVTGKSLPQILGERMGSAGSFLFFAQAEVIAIATDLAEVIGGAIALNLLFGLPLLVGGLIIGAVSTVLLLFQGGKTHKIFERLVIGLLLVITFGFIAGLFMDPPNPLKVAEGLIPRFNGGASVLMAASMLGATVMPHAIYLHSTLVNDHYAHKAHKPSIKEMLHGSRIDVVWALALAGSVNIALLVLAANSLHGMGGTDTIEGAQHTISQVLGPTVGTVFSIGLLASSLSSTSVGTYAGSEIMKGLLHWNVPMWACRITTLVPALVVLALTSNPTEALIIGQVVLSIGIPFAVIPLMRYTHNKQIMGKYVDGPVKHAICLLVVAVIIALNLVLIVLTLMGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWQ4</accession>
    <name>B8DWQ4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Possible Etk-like tyrosine kinase involved in Eps biosynthesis</fullName>
            <ecNumber evidence="18">2.7.10.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ordered locus">BLA_0612</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the etk/wzc family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="18"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0612"/>
    <dbReference type="EnsemblBacteria" id="ACL28905">
        <property type="protein sequence ID" value="ACL28905"/>
        <property type="gene ID" value="BLA_0612"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0612"/>
    <dbReference type="HOGENOM" id="CLU_009912_4_1_11"/>
    <dbReference type="OMA" id="TQVKYTP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="16">
        <location>
            <begin position="33"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_31" evidence="17">
        <location>
            <begin position="308"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ACL28905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="498" mass="53568" checksum="FE5299CADCF24B12" modified="2009-03-03" version="1">MLEWKALYMAENEVNRYSQSQSQTPVPAHEGMTIVDLLSILRKHIITIAVTFVVILGVDILYTAMSPVAYTTTTQLFATYNSSNDSANSSEQYSGSSYIMSQIKSYPDLAKTQSVLQPVVDELKLDTTPISLASQITVTNPTNTAFVNIAVTDADPSTAARIANGVAASLSNVVEKSLYTAGSNSAVKLSIVQPAQVPTKQSSPKWSLNILVGVLGGLIIGILAALLKDVLSKKIQDESDVTDIVDAPIIGRVVKDDILAGSSPVVVSEPGSPIAEDFRRIRTNLSFSTPVEGTNCRLVVVTSAGASEGKTTISVNIAAALAEDGPRVLLIDADLRHPSVAHKIDIDGSAGLTHVLSGQAAVKDVIQRYWKPNLHIIPAGPKPPNASTLLNSPLMTTLVANAMQQYDYIIIDTAPMVVANDAVIFMKQGGTLEMVCRRDQTLKRDLHEIADELETLDMPVTGVIINCAKENKKALENSNYYYYSNSSPAEKNRKNRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWT4</accession>
    <name>B8DWT4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative plasmid transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">traSA</name>
        <name evidence="1" type="ordered locus">BLA_0642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219161.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0642"/>
    <dbReference type="EnsemblBacteria" id="ACL28935">
        <property type="protein sequence ID" value="ACL28935"/>
        <property type="gene ID" value="BLA_0642"/>
    </dbReference>
    <dbReference type="GeneID" id="66533775"/>
    <dbReference type="KEGG" id="bla:BLA_0642"/>
    <dbReference type="HOGENOM" id="CLU_1096964_0_0_11"/>
    <dbReference type="OMA" id="KGSIMAT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="253" mass="28216" checksum="DB63E2AC5343A0BD" modified="2009-03-03" version="1">MNIFRNHRKLPSDRYSLGLDIADPKRTVTIPRSAHLAVIGESNSGKGSVIANIISQEVAFGGEIWFIDLKAGMEAENYCNVLARKAYTLEEAYDLLTDFNSNVDTLAAEWRGKTRSLTDAQTCHRLLVIDEAADMVRSGPNKKLSDSCIELVRSILSRSRALNCTVVVATQNPRVSTSLPYRSLLLTTVALRLNSKGEATMALGEDAVKRGARPWQIPFSRPGDGYLWDTETNQTVYLHVPFISDEELHRLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWU5</accession>
    <name>B8DWU5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0653</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619794.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0653"/>
    <dbReference type="EnsemblBacteria" id="ACL28946">
        <property type="protein sequence ID" value="ACL28946"/>
        <property type="gene ID" value="BLA_0653"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0653"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.681"/>
    <dbReference type="HOGENOM" id="CLU_018430_0_0_11"/>
    <dbReference type="OMA" id="QVSVWWA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867674" evidence="3">
        <location>
            <begin position="37"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="645"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="698" mass="75947" checksum="11B65A73A55DF048" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWV6</accession>
    <name>B8DWV6_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription termination factor Rho</fullName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">rho</name>
        <name evidence="12" type="ordered locus">BLA_0664</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619799.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0664"/>
    <dbReference type="EnsemblBacteria" id="ACL28957">
        <property type="protein sequence ID" value="ACL28957"/>
        <property type="gene ID" value="BLA_0664"/>
    </dbReference>
    <dbReference type="GeneID" id="66533797"/>
    <dbReference type="KEGG" id="bla:BLA_0664"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.692"/>
    <dbReference type="HOGENOM" id="CLU_016377_3_0_11"/>
    <dbReference type="OMA" id="TTDLMGA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036269">
        <property type="entry name" value="Rho_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00959">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68912">
        <property type="entry name" value="SSF68912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 8" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="11">
        <location>
            <begin position="294"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="41"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="209"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="415"/>
            <end position="420"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="427"/>
            <end position="432"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACL28957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="676" mass="75091" checksum="D2CEF9013BC116F2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWV7</accession>
    <name>B8DWV7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amine oxidase:FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0665"/>
    <dbReference type="EnsemblBacteria" id="ACL28958">
        <property type="protein sequence ID" value="ACL28958"/>
        <property type="gene ID" value="BLA_0665"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0665"/>
    <dbReference type="HOGENOM" id="CLU_026719_1_0_11"/>
    <dbReference type="OMA" id="DGPSWLI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="532" mass="60623" checksum="C71164A5FA9812F6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSI2</accession>
    <name>GATB_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName evidence="1">Asp/Glu-ADT subunit B</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatB</name>
        <name type="ordered locus">BLA_0668</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219120.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DSI2"/>
    <dbReference type="SMR" id="B8DSI2"/>
    <dbReference type="STRING" id="442563.BLA_0668"/>
    <dbReference type="EnsemblBacteria" id="ACL28961">
        <property type="protein sequence ID" value="ACL28961"/>
        <property type="gene ID" value="BLA_0668"/>
    </dbReference>
    <dbReference type="GeneID" id="66533801"/>
    <dbReference type="KEGG" id="bla:BLA_0668"/>
    <dbReference type="HOGENOM" id="CLU_019240_0_0_11"/>
    <dbReference type="OMA" id="ARKWWMG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000122509" description="Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B">
        <location>
            <begin position="1"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00121"/>
        </source>
    </evidence>
    <sequence length="499" mass="55096" checksum="9E045289CB28080B" modified="2009-03-03" version="1">MAEKLMKYSEAVKEFDPVIGLETHVELSTRTKLFCPAPISFGAEPNTELTPVSLGLPGSLPVLNATAVDYAIKLGLALHCQINEWSQFSRKNYFYPDMPRDYQISQYDKPTNGEGYLDVELEDGSVFRVPIERAHIEDDAGKNTHVGGADGRIEGADHSLVDYNRAGVPLIEIVTKPITGVGDRGPEIAGAYMRAIRDIVRALNISHARMEQGNMRADVNVSLRRSPDDPFGTRSETKNVNSFRGIERTVQYEIRRQAAILNDGGEILQETRHWDEASQATAGGRVKSDADDYRYFPDPDLVMLHITPEHIERLKAEMPEMPRERRNRLKAEWKFSDVEMRDVINADALDLIEETVKLGASPAGAKKWWLGELSREANAKGISLEELPINAQEVADVEKLIAEGKLNDKLAKQTVALVLKGEGTPAEIVEKHGFKVVSDDGMLQTAVDEAMAANPDVVEKLRSGNMKPMGAIIGAVMRATKGQADAKAVTKIVMEKIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSK8</accession>
    <name>B8DSK8_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Ribokinase</fullName>
            <shortName evidence="6">RK</shortName>
            <ecNumber evidence="2 6">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">rbsK</name>
        <name evidence="8" type="ordered locus">BLA_0694</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + D-ribose = ADP + D-ribose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="2 6"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219087.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0694"/>
    <dbReference type="EnsemblBacteria" id="ACL28987">
        <property type="protein sequence ID" value="ACL28987"/>
        <property type="gene ID" value="BLA_0694"/>
    </dbReference>
    <dbReference type="GeneID" id="66533827"/>
    <dbReference type="KEGG" id="bla:BLA_0694"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.724"/>
    <dbReference type="HOGENOM" id="CLU_027634_2_1_11"/>
    <dbReference type="OMA" id="IPWRDEL"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="D_ribokin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0630">Potassium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="7">
        <location>
            <begin position="14"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="22"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="50"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="236"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="270"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="322" mass="33566" checksum="DF14D3782CF14F39" modified="2009-03-03" version="1">MNQILDKLEQIHGSVSVVGSMNADYTVTTERLPGPGETVTGGPLQVLPGGKSGNQAAAAAKLGATVRMFGAVGSDSNADFLLTQLASAGVNTDGIRKVLGPSGTTVITVDSHGENTIVYSPGSNANVTVEYIESQRDLLTASSVLGLCLESPLETVTACATMCHDAGMKVLLNDSPFIATLPSELIAHADILLVNEHELVQLLHIDEPEDDDWDSFDWAQAQNRLSEFGFDQAIVTLGGDGSVVLDSTVDPSIIRIAPVRVDAVDTTGCGDSFMGTVLASLASGLSLEESAQLASYVSAYAATGYGAQASYGTAAQIRERFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSL1</accession>
    <name>B8DSL1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribose operon repressor RbsR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rbsR</name>
        <name evidence="5" type="ordered locus">BLA_0697</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619808.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0697"/>
    <dbReference type="EnsemblBacteria" id="ACL28990">
        <property type="protein sequence ID" value="ACL28990"/>
        <property type="gene ID" value="BLA_0697"/>
    </dbReference>
    <dbReference type="GeneID" id="66533830"/>
    <dbReference type="KEGG" id="bla:BLA_0697"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.727"/>
    <dbReference type="HOGENOM" id="CLU_037628_6_0_11"/>
    <dbReference type="OMA" id="VIKYCYL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="348" mass="38767" checksum="46F8C461E5E40FAC" modified="2009-03-03" version="1">MVRRVTLREVAQEAQVSVATASLVLNNKPSRISQPTQQRIRDVARRLHYVVNENARGLVTNETRLIALIVPDIENMFFASLSKCLETECRRNGYQLFISNSDDDRTLERRLMRNFVGRDIDGLLLIPSIDSYTDRALLRDQICASPCPIVIIDRLITADICDGVGFDNELGGRLAAKKLLCAGHRRFACITGNKDSVNANTRCYGFLKTLQEHEVPADSILTLDGNYRFSGGYDAADAVADFGATCLFCCNDLMALGAIDRFRELGIAIPADISIIGYDNIVKRFGLLTRLTTVEQNVSELASQSWQCLYRHIQHHDSGRNCAEANDLLLLEPQLVEGDTVAQAPIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSN7</accession>
    <name>B8DSN7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DppA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dppA</name>
        <name evidence="3" type="ordered locus">BLA_0723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218720.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="SMR" id="B8DSN7"/>
    <dbReference type="STRING" id="442563.BLA_0723"/>
    <dbReference type="EnsemblBacteria" id="ACL29016">
        <property type="protein sequence ID" value="ACL29016"/>
        <property type="gene ID" value="BLA_0723"/>
    </dbReference>
    <dbReference type="GeneID" id="66533484"/>
    <dbReference type="KEGG" id="bla:BLA_0723"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.754"/>
    <dbReference type="HOGENOM" id="CLU_017028_0_3_11"/>
    <dbReference type="OMA" id="SSWGDPQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870749" evidence="1">
        <location>
            <begin position="33"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="83"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="546" mass="59295" checksum="D104EEAC7951DB58" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSP5</accession>
    <name>B8DSP5_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal subunit assembly factor BipA</fullName>
            <ecNumber evidence="2">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GTP-binding protein BipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bipA</name>
        <name evidence="4" type="ordered locus">BLA_0731</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Binds to ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218705.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0731"/>
    <dbReference type="EnsemblBacteria" id="ACL29024">
        <property type="protein sequence ID" value="ACL29024"/>
        <property type="gene ID" value="BLA_0731"/>
    </dbReference>
    <dbReference type="GeneID" id="66533492"/>
    <dbReference type="KEGG" id="bla:BLA_0731"/>
    <dbReference type="HOGENOM" id="CLU_017016_4_0_11"/>
    <dbReference type="OMA" id="MSMLFTI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03710">
        <property type="entry name" value="BipA_TypA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00849">
        <property type="entry name" value="BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035651">
        <property type="entry name" value="BipA_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006298">
        <property type="entry name" value="TypA_GTP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="PTHR42908:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01394">
        <property type="entry name" value="TypA_BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="5"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="17"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="141"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="643" mass="70315" checksum="BA314B210737178E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSQ1</accession>
    <name>RL35_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmI</name>
        <name type="ordered locus">BLA_0737</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218698.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DSQ1"/>
    <dbReference type="SMR" id="B8DSQ1"/>
    <dbReference type="STRING" id="442563.BLA_0737"/>
    <dbReference type="EnsemblBacteria" id="ACL29030">
        <property type="protein sequence ID" value="ACL29030"/>
        <property type="gene ID" value="BLA_0737"/>
    </dbReference>
    <dbReference type="GeneID" id="66533498"/>
    <dbReference type="KEGG" id="bla:BLA_0737"/>
    <dbReference type="HOGENOM" id="CLU_169643_4_2_11"/>
    <dbReference type="OMA" id="DGSAMRH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_L35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000146122" description="50S ribosomal protein L35">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="63" mass="6996" checksum="BA982C986D872728" modified="2009-03-03" version="1">MPKMKTKTAAAKRVRLTATGKVMHAGSGMRHNLEHKSARKRRALKRDDVLQTAQAKKMKGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSQ4</accession>
    <name>B8DSQ4_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent glyceraldehyde-3-phosphate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gap</name>
        <name evidence="10" type="ordered locus">BLA_0740</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218695.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0740"/>
    <dbReference type="EnsemblBacteria" id="ACL29033">
        <property type="protein sequence ID" value="ACL29033"/>
        <property type="gene ID" value="BLA_0740"/>
    </dbReference>
    <dbReference type="GeneID" id="66533501"/>
    <dbReference type="KEGG" id="bla:BLA_0740"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.771"/>
    <dbReference type="HOGENOM" id="CLU_030140_0_0_11"/>
    <dbReference type="OMA" id="NCVAPMA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="5">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="5">
        <location>
            <begin position="226"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="7">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL29033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="352" mass="37897" checksum="7AC6B2F33B7C0044" modified="2009-03-03" version="1">MTVKIGINGFGRIGRLAFRRIFELQEKGGEAADIEVTAINDLTSPAALAYLLKYDSTHGVFKHVDGTPVDVKSTDTAIVVDGKEYPVYAERDARDLKWVANDGVEFVLECTGFYTSAEKSQAHLDAGAKKVLISAPAKDETTPTVVFGVNHDILKKDDNIVSAGSCTTNSMAAMVKLLNDKWGIKAGFMTTIHAYTGTQMILDGPRGNKSGRALRAAAINTIPHSTGAAKAIGKVVPEVNGKLQGHAQRVQVPDGSITELFTVLEKDATVDEINAAFKDAFADCAYYGYNDDEIVSGDIVGDTHGGVFDPTQTDVNTVDGVTMARTVAFYDNEYGFTSNMVRTLEYFAEISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSQ5</accession>
    <name>B8DSQ5_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase</fullName>
            <ecNumber evidence="3">4.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_0741</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218694.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0741"/>
    <dbReference type="EnsemblBacteria" id="ACL29034">
        <property type="protein sequence ID" value="ACL29034"/>
        <property type="gene ID" value="BLA_0741"/>
    </dbReference>
    <dbReference type="GeneID" id="66533502"/>
    <dbReference type="KEGG" id="bla:BLA_0741"/>
    <dbReference type="HOGENOM" id="CLU_094875_1_1_11"/>
    <dbReference type="OMA" id="PYDYVEH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00002">
        <property type="entry name" value="YbaK_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004369">
        <property type="entry name" value="Prolyl-tRNA_editing_YbaK/EbsC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006181">
        <property type="entry name" value="EbsC_YbaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00011">
        <property type="entry name" value="YbaK_EbsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="4">
        <location>
            <begin position="42"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="169" mass="18247" checksum="DE608DCF0C753793" modified="2009-03-03" version="1">MGKKKRRAAATPAIKQLEDTKVTFTTHEYEHSNDDADGYGLEAARKLGYDERQVFKTLMADTGDERVIGVVPVNGHMSLKELAHAVGAKKAEMADPKVAMRESGYVVGGISPLGQKTQHRTVLDESALEFDEILVSGGKRGLSLGVNPHDLLAVLDATTAPIATQKKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSR3</accession>
    <name>B8DSR3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and a HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_0749</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218684.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0749"/>
    <dbReference type="EnsemblBacteria" id="ACL29042">
        <property type="protein sequence ID" value="ACL29042"/>
        <property type="gene ID" value="BLA_0749"/>
    </dbReference>
    <dbReference type="GeneID" id="66533510"/>
    <dbReference type="KEGG" id="bla:BLA_0749"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.780"/>
    <dbReference type="HOGENOM" id="CLU_1297793_0_0_11"/>
    <dbReference type="OMA" id="CAPIRIL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="16"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="140"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="207" mass="22993" checksum="88743FEF1F957368" modified="2009-03-03" version="1">MTTKTSEATDRHGRYTLGIVDNDPLVAEAPRSSFERFHAPLEVIWALTDPEDALVHCLHAKGRPDVLLTDIDMPRLSGLGLFHELQTRKLPITVIGISAFPNIAEEPGLVILPKESAVEEIVQLAGMLRRDDDLTRWFPTPTKPNPLSPSELHALTHYSEGLTTTAIAHTMHVSESSMKTFAKRAYEKLDAHSRTEAIAICVRNGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DST6</accession>
    <name>B8DST6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable permease of ABC transporter for peptides</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BLA_0772</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218654.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0772"/>
    <dbReference type="EnsemblBacteria" id="ACL29065">
        <property type="protein sequence ID" value="ACL29065"/>
        <property type="gene ID" value="BLA_0772"/>
    </dbReference>
    <dbReference type="GeneID" id="66533534"/>
    <dbReference type="KEGG" id="bla:BLA_0772"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.804"/>
    <dbReference type="HOGENOM" id="CLU_036879_0_3_11"/>
    <dbReference type="OMA" id="RKEWYAN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="120"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="363" mass="39378" checksum="676553FCD08D1AEE" modified="2009-03-03" version="1">MSQAIASPADSAPSKPTAHKNRLSAGFFRFILGRFLLIIPTVFILVTIVFFVMRATGDPISAPMGGRLTPEELQRRIHGAGYDRPLIVQYFDYLGGLLHGDLGRTLTDNQPVISVLTRYGAATLELALLSLVVALLVGIGFGRIAAKHRDRAQDAGIRMFAILCYATPVFFLGLVLKLIFSVGLGVLPSSGRSSLQSEMQFSRLVSPTGLYIVDALQPGDMKVLGDVLMHAILPALALGLLTAGVFIRLVRTNVISTYNAGYIEAARSRGVSEKRLMSKHAWRPALIPIITVMGMQIALLLAGAVLTETTFEWKGLGFMLSNYLKARDFVAVQGIVILIAIIVSVVNFIVDVISALIDPRVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSU3</accession>
    <name>B8DSU3_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase</fullName>
            <ecNumber evidence="6 7">6.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">D-alanyl-D-alanine-adding enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">murF</name>
        <name evidence="11" type="ordered locus">BLA_0780</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine</text>
            <dbReference type="Rhea" id="RHEA:28374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MurCDEF family. MurF subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.10" evidence="6 7"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218644.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0780"/>
    <dbReference type="EnsemblBacteria" id="ACL29072">
        <property type="protein sequence ID" value="ACL29072"/>
        <property type="gene ID" value="BLA_0780"/>
    </dbReference>
    <dbReference type="GeneID" id="66533542"/>
    <dbReference type="KEGG" id="bla:BLA_0780"/>
    <dbReference type="HOGENOM" id="CLU_031507_0_0_11"/>
    <dbReference type="OMA" id="VEMGANH"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047480">
        <property type="term" value="F:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008766">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02019">
        <property type="entry name" value="MurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005863">
        <property type="entry name" value="UDP-N-AcMur_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01143">
        <property type="entry name" value="murF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 6 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 6 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="8">
        <location>
            <begin position="31"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="10">
        <location>
            <begin position="117"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="9">
        <location>
            <begin position="333"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="119"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL29072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="496" mass="52195" checksum="8A9748C59AF386F6" modified="2009-03-03" version="1">MMRMTLAQMVQAVHGSAEHCDCDDLETVTATSVVTDSRQVVDGALFVAIAGEHVDGHDFVDAAARQGAAAALVEREIKSAPIAQIVVPDTVAALGALAKANLEARKAIDEPFTIIGITGSVGKTTTKDLLHALLSTQGETVAPKGSFNNEIGLPLTALKVGERTRYLVAEMGANHIGEIARLTKIAPPDIAVVLKVGVAHLGEFGSVERIAQAKSEIVRGEAPNAITVLNADDERVAAMSGIAKGDVFWFGIDKAQAHDIDGYMAADDIALDDLGHPVFELVSSQGVEQRVSLGIGGRHNVMNALAAASVAKLLGMPLERIAQVLADTRRISPHRMAVSEVERDGARFTLIDDSFNANPDSMRAGIDGLMAWRSQEDQQPYRVAVLGSMLELGSDEHNLHRTIGAYALDGGVDALICVGGGDDASLNALAQDIADGGTEAKDADDMRPVRAVKTTQQADDLIRALNAEHPDMLVLLKGSHASGLSALATQWAAEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSU4</accession>
    <name>B8DSU4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UDP-N-acetylmuramyl-tripeptide synthetases</fullName>
            <ecNumber evidence="1">6.3.2.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murE</name>
        <name evidence="1" type="ordered locus">BLA_0781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.2.13" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218643.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0781"/>
    <dbReference type="EnsemblBacteria" id="ACL29073">
        <property type="protein sequence ID" value="ACL29073"/>
        <property type="gene ID" value="BLA_0781"/>
    </dbReference>
    <dbReference type="GeneID" id="66533543"/>
    <dbReference type="KEGG" id="bla:BLA_0781"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.814"/>
    <dbReference type="HOGENOM" id="CLU_810546_0_0_11"/>
    <dbReference type="OMA" id="KFDSHAN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008765">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="293" mass="31101" checksum="652CF3421E58C81E" modified="2009-03-03" version="1">MSSLSEAATHRTTLGMLADRYGYELSPKFSRAVTVTSLASDIDSVTAGSLFMPGKRIDAARVAAASRKGAYAVMLPKSMRSSDLEADIPLVYADPTPREIGQIASNMTGNPAGTLAVFAIAGINDDQIHANVEMLSQFLHMLGNPVGTICAGDSQSLDRFLDLRYPMDILSMQRVLSVCAEDGAAAVILALDDNTLQPDALQSVGADVIGYDGVANPMAGQDLVEQACERYGCGIDEGTHIAFRTDETDQMAVQADFGLDKVRSLSLAIAMVMAAGVKKANIRSALRVSRELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSV8</accession>
    <name>B8DSV8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent helicase HrpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hrpA</name>
        <name evidence="3" type="ordered locus">BLA_0795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218618.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0795"/>
    <dbReference type="EnsemblBacteria" id="ACL29087">
        <property type="protein sequence ID" value="ACL29087"/>
        <property type="gene ID" value="BLA_0795"/>
    </dbReference>
    <dbReference type="GeneID" id="66533557"/>
    <dbReference type="KEGG" id="bla:BLA_0795"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.828"/>
    <dbReference type="HOGENOM" id="CLU_001832_3_3_11"/>
    <dbReference type="OMA" id="YERVTLY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024590">
        <property type="entry name" value="HrpA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010222">
        <property type="entry name" value="RNA_helicase_HrpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11898">
        <property type="entry name" value="DUF3418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01967">
        <property type="entry name" value="DEAH_box_HrpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="19"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="241"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="1348" mass="150440" checksum="86A6E8423576BA70" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSY4</accession>
    <name>B8DSY4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Possible solute binding protein of ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218585.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0821"/>
    <dbReference type="EnsemblBacteria" id="ACL29113">
        <property type="protein sequence ID" value="ACL29113"/>
        <property type="gene ID" value="BLA_0821"/>
    </dbReference>
    <dbReference type="GeneID" id="66533583"/>
    <dbReference type="KEGG" id="bla:BLA_0821"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.855"/>
    <dbReference type="HOGENOM" id="CLU_028871_6_1_11"/>
    <dbReference type="OMA" id="DWFVNPD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027939">
        <property type="entry name" value="NMT1/THI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528">
        <property type="entry name" value="PTHR31528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870469" evidence="1">
        <location>
            <begin position="37"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="56"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="360" mass="39112" checksum="EA94BF709E5E4451" modified="2009-03-03" version="1">MKSPRHIHRHLTRIIAMLAALPTIFAVTACGSTSSANGGDDGLTKVTFMLSWAPDTNHIGVYVAKNKGYYRQAGLDVNIVAVAQSGAEQAVNNGVADFALSNLTNVSTYSTKGTELRQVMQIQQKTSAIWCALASNASITRPRDLDGKTFATFGSSESDAVVRRMIQHDGGKGNFDKVTVGTSTFQTLESGRADFGGFYSTWEGVQAKLNGPKLNCFTEPEYGVPGNADSIGIITSDRLIAQNPDLVKRFVQATQRGYEYAYDHGDEAADILVKEAPEANLDPEFVRESMKTIIDGQYWGDREQIISGKQTFGLADYQGTQAYFDFLAQSDAYTDADGRVVHAAPQSKDLATDEFLKQAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT24</accession>
    <name>B8DT24_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1,4-beta-N-acetylmuramidase</fullName>
            <ecNumber evidence="2">3.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lytC</name>
        <name evidence="2" type="ordered locus">BLA_0861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619854.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0861"/>
    <dbReference type="CAZy" id="GH25">
        <property type="family name" value="Glycoside Hydrolase Family 25"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29153">
        <property type="protein sequence ID" value="ACL29153"/>
        <property type="gene ID" value="BLA_0861"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0861"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.899"/>
    <dbReference type="HOGENOM" id="CLU_961951_0_0_11"/>
    <dbReference type="OMA" id="IDWTHRY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="291" mass="33081" checksum="23FA5551409C9EBE" modified="2009-03-03" version="1">MRMGLGLHEYGGWCNPNAVRRVARRLKTAVCALLGCVLAMFALTGCGNVNGSDQADAWNEAADPWSYSFGVHVFTEGDGRVLRPVWRVIDVAEHQRNINWQKVKQSEVDAAILRIGYGHGNEDKYFKNNLAQVRVNRIPHGLYLYSYAYDTDFAREEANFVLQTLRRYSITDKSVPIFYDMEHLDDWGGHTMPTRPIQFEQIAKVFFGVLEDAGYTNLGIYTYAHNMATRLDSDWLHGHANWIASYSDTLEYDFAGCPDLHAWQYTSTARVPGVTGDVDVSVFDPRFFDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT71</accession>
    <name>B8DT71_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">4-alpha-glucanotransferase</fullName>
            <ecNumber evidence="3 7">2.4.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Amylomaltase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 7">Disproportionating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">malQ</name>
        <name evidence="8" type="ordered locus">BLA_0908</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the disproportionating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="3 7"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219255.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0908"/>
    <dbReference type="CAZy" id="GH77">
        <property type="family name" value="Glycoside Hydrolase Family 77"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29200">
        <property type="protein sequence ID" value="ACL29200"/>
        <property type="gene ID" value="BLA_0908"/>
    </dbReference>
    <dbReference type="GeneID" id="66533888"/>
    <dbReference type="KEGG" id="bla:BLA_0908"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.951"/>
    <dbReference type="HOGENOM" id="CLU_022072_1_0_11"/>
    <dbReference type="OMA" id="QYPNWRL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102500">
        <property type="term" value="F:beta-maltose 4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003385">
        <property type="entry name" value="Glyco_hydro_77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32438">
        <property type="entry name" value="PTHR32438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02446">
        <property type="entry name" value="Glyco_hydro_77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00217">
        <property type="entry name" value="malQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="732" mass="80893" checksum="D81D5548BD91B6D7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT88</accession>
    <name>B8DT88_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_0925</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217580.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0925"/>
    <dbReference type="EnsemblBacteria" id="ACL29217">
        <property type="protein sequence ID" value="ACL29217"/>
        <property type="gene ID" value="BLA_0925"/>
    </dbReference>
    <dbReference type="GeneID" id="66533461"/>
    <dbReference type="KEGG" id="bla:BLA_0925"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.968"/>
    <dbReference type="HOGENOM" id="CLU_058671_1_0_11"/>
    <dbReference type="OMA" id="HMLRVYN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="PTHR23291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="261" mass="28481" checksum="6C9F45C00F9ED8C7" modified="2009-03-03" version="1">MTYGQQPMNGSPYGQQPYGQQPMNYANTINVQASQSYERAEHVSVTRAYGEMCLGLLVTAAMAIFTQMSGFYMRFLQATGGMGMWILAIVEIGLAIYLGMRVMKMSTTAARVCFYVYAALMGVTLSTIFLAYDLGTIGIAFLVSAGFYFALTMFGLTTKGNMLKAGPILMIALVVLIIAEVIMMFVAPSNTMLKVVTAIGILLFAGLTIYDAQFTKKAFAVYASQGPEAIKKISILCALNLYLDFINLFLYILQALGLSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTA2</accession>
    <name>B8DTA2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217602.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0939"/>
    <dbReference type="EnsemblBacteria" id="ACL29231">
        <property type="protein sequence ID" value="ACL29231"/>
        <property type="gene ID" value="BLA_0939"/>
    </dbReference>
    <dbReference type="GeneID" id="66533447"/>
    <dbReference type="KEGG" id="bla:BLA_0939"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.982"/>
    <dbReference type="HOGENOM" id="CLU_083826_0_0_11"/>
    <dbReference type="OMA" id="EHQADLH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="188" mass="20752" checksum="6068989A33850B72" modified="2009-03-03" version="1">MTDLNNSNDGEETKPHDSGRNGGDSSEISEEAAWNRFLDEYSDDLGEVERSRTARKFDRHATRQDKREEKRAILSVNDLKQGSFVDSSGPRDFTQSSWLDTDDVMDRSSVFTPPNPDLGQIRWSRLICGILLVVGVAGIIATAFLPAWATVLGIVFGISILVGAGGLFVTHRGHDETKRDEEDDGARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTC3</accession>
    <name>B8DTC3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Methionine import ATP-binding protein MetN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BLA_0962</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217623.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0962"/>
    <dbReference type="EnsemblBacteria" id="ACL29252">
        <property type="protein sequence ID" value="ACL29252"/>
        <property type="gene ID" value="BLA_0962"/>
    </dbReference>
    <dbReference type="GeneID" id="66533427"/>
    <dbReference type="KEGG" id="bla:BLA_0962"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1005"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_3_11"/>
    <dbReference type="OMA" id="VFITHEI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033232">
        <property type="term" value="F:ABC-type D-methionine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03258">
        <property type="entry name" value="ABC_MetN_methionine_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026253">
        <property type="entry name" value="ABC_MetN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041701">
        <property type="entry name" value="MetN_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018449">
        <property type="entry name" value="NIL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43166:SF5">
        <property type="entry name" value="PTHR43166:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09383">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4 6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="9"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="402"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL29252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="431" mass="46942" checksum="44F4EF7F982C6A24" modified="2009-03-03" version="1">MTQEKNAIIEFDHVSKVYAGRGKKQTKAVDDVTLSIDEGDIYGIIGYSGAGKSTLVRMINALENPTSGTVTVMGQQVSGMSESKLRAVRQKIGMIFQQFNLFSTKTVAQNVAYPLQLDHWRKDYQDKRVKELLEFVGLSEHANRYPAQLSGGQKQRVGIARALATNPKILLADEATSALDPETTTEVLELLRKINEQLGVTIVLITHQMNVVQQIAHHVAVMSGGRLVEKGTVYRVFAAPQEEVTKRFIATAMSGLPDETRVEQMHRDWSGRLVTVIVRQHDIDDENANTRIPSSGQNISELISKHGVASNLIYGGIDTVQGVAIGAITYTFDGPEAEVEPFLAELAENSDIVDFGTAAEPVDYAQAVERAGIAAPENRAADDHANTNALDFEQVDDVVTVSRINGQDTPGAQADTRVASDDANGARKETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTD6</accession>
    <name>B8DTD6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted aspartate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217642.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0975"/>
    <dbReference type="EnsemblBacteria" id="ACL29265">
        <property type="protein sequence ID" value="ACL29265"/>
        <property type="gene ID" value="BLA_0975"/>
    </dbReference>
    <dbReference type="GeneID" id="66533412"/>
    <dbReference type="KEGG" id="bla:BLA_0975"/>
    <dbReference type="HOGENOM" id="CLU_017584_15_0_11"/>
    <dbReference type="OMA" id="NEVCDVN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027619">
        <property type="entry name" value="C_S_lyase_PatB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04350">
        <property type="entry name" value="C_S_lyase_PatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="31"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="406" mass="45165" checksum="BEA5B8D9EFBCEBDC" modified="2009-03-03" version="1">MYDFETWPERHDTTSVKWKMIETELGVGHEDVLALSVADMEFVTPPAVVEALVDAARNDVFGYDYATDEYLAAVCDWMRRRHGLEADPKLISLSAGVMPAVNTALRAFTHPGDAVIIQRPVYYPFTNAAMNNGLEILNNALLFDGETGRYSMDFEDLERKASDPRCKAIMLCNPHNPVGRVWTAEELRMLGDICVANDVMILCDEIHGDLEHPGHAVTMFGTLGERYADHLIEFTAPSKSFNLAGLLCSNAIFHNAKVKQEFDIAAAKTGGSTVNHLGMVACMAAYARCEDWFEEMLAVVRRNLDTVRAFADTHDGIRLIEPEGTYLAWLDCRGLGLSNDELETFMHEQARLYFDEGYLFGQEGSGFERINLACPVRVIERMCRQLDAALCKLGVGPVAADFADCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTG6</accession>
    <name>B8DTG6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29295">
        <property type="protein sequence ID" value="ACL29295"/>
        <property type="gene ID" value="BLA_1005"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1005"/>
    <dbReference type="HOGENOM" id="CLU_3402293_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="30" mass="3412" checksum="66457DBE276649EC" modified="2009-03-03" version="1">MLDEARTSVGPHTCVFTFIWRLLDVAQAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTH1</accession>
    <name>B8DTH1_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="5">G6PD</shortName>
            <ecNumber evidence="5">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">zwf</name>
        <name evidence="9" type="ordered locus">BLA_1010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217688.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1010"/>
    <dbReference type="EnsemblBacteria" id="ACL29300">
        <property type="protein sequence ID" value="ACL29300"/>
        <property type="gene ID" value="BLA_1010"/>
    </dbReference>
    <dbReference type="GeneID" id="66533378"/>
    <dbReference type="KEGG" id="bla:BLA_1010"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1052"/>
    <dbReference type="HOGENOM" id="CLU_013524_5_1_11"/>
    <dbReference type="OMA" id="VEICVYE"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="2 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G6PD_N" evidence="7">
        <location>
            <begin position="36"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="G6PD_C" evidence="8">
        <location>
            <begin position="221"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL29300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="519" mass="58518" checksum="4B6B422D41B8F781" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-12-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTJ3</accession>
    <name>B8DTJ3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cd efflux system component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29322">
        <property type="protein sequence ID" value="ACL29322"/>
        <property type="gene ID" value="BLA_1034"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1034"/>
    <dbReference type="HOGENOM" id="CLU_097821_0_0_11"/>
    <dbReference type="OMA" id="SNTHEST"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="206" mass="21731" checksum="410009DE791239EF" modified="2009-03-03" version="1">MASKGTAVKASNTHESTVTPAGSSVQVHGESGMPVMLVQAIIIAATLCVCELVCSPIYLSFTPGLFPIGSWVLVAMLLAVAFAYVVGFALLWCAESFAYRMKRKLQPVVYSLIGAVGFAVWTIWVVLGFMNMIAGPVLGQTVSHHDTIVAGVNGAMLGFASFFFASTLGERLAKYTKVMIAIGVITVLLAIAGGFLFAAMYQSVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTK6</accession>
    <name>B8DTK6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative binding protein-dependent transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_1047</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219351.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1047"/>
    <dbReference type="EnsemblBacteria" id="ACL29335">
        <property type="protein sequence ID" value="ACL29335"/>
        <property type="gene ID" value="BLA_1047"/>
    </dbReference>
    <dbReference type="GeneID" id="66532876"/>
    <dbReference type="KEGG" id="bla:BLA_1047"/>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_11"/>
    <dbReference type="OMA" id="YVFACHE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="84"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="289" mass="31571" checksum="37AED39E825F6C34" modified="2009-03-03" version="1">MSAATAYSKNNGFHKSSKTPWGNPVVYFFSLVLVAICVVPVLYIIFGGFRTNAQITNNPAGLPNPWVISNYKEVITSDIFWTELVNSLIVGICTMVGVVVLGIMVSYVIARYRFRYSALMYALFSAGLMFPMTVGITPLYLMIRNLGLSNSLAGIILPQIAFGLPQTIIILVPFLQSIPMELEEACLLDGCSRLGFFWRMVIPLSMPGVATTGILTFVGSWNGYMLPLFVLSDESKYTLPLGVQMFSSQHSVDTARVLAFTSLAMLPALICFTIFQKKIVGGLTGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTL1</accession>
    <name>B8DTL1_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylulose kinase</fullName>
            <shortName evidence="3">Xylulokinase</shortName>
            <ecNumber evidence="3">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">xylB</name>
        <name evidence="6" type="ordered locus">BLA_1052</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + D-xylulose = ADP + D-xylulose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219345.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1052"/>
    <dbReference type="EnsemblBacteria" id="ACL29340">
        <property type="protein sequence ID" value="ACL29340"/>
        <property type="gene ID" value="BLA_1052"/>
    </dbReference>
    <dbReference type="GeneID" id="66532881"/>
    <dbReference type="KEGG" id="bla:BLA_1052"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1100"/>
    <dbReference type="HOGENOM" id="CLU_009281_12_0_11"/>
    <dbReference type="OMA" id="WHVMGVT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005998">
        <property type="term" value="P:xylulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02220">
        <property type="entry name" value="XylB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006000">
        <property type="entry name" value="Xylulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 3" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="FGGY_N" evidence="4">
        <location>
            <begin position="6"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="5">
        <location>
            <begin position="292"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="73"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="site" description="Important for activity" evidence="3">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="509" mass="53114" checksum="26387042928860B2" modified="2009-03-03" version="1">MEPMLVAGVDTSTQSCKVRVTDARTGKLVRFGQAKHPDGSTVDPQAWWEAFLEASEQAGGLDDVSAIAVGGQQHGMVILDEQGRVIRDAMLWNDISSAPQAVELIDELGAAPAADGEPEDRHARGISRWVRAVGSSPVASYTLTKLRWVSEHEPQHAARIAAVCLPHDWLSWRIAGFGPVDPGEDAHLDALFTDRSDASGTLYFDAASNTYRRDLLARGLQSAAADEPAPECLQAAARIVLPAVLGPQEAAKVKASPSIAGGAVDGGCIIAPGGGDNAMAALGLGMAVGDVSVSLGTSGVAAAVSERPAYDLNGSVSGFADCTGHFLPLACTINASRILDAGRAVLDVDYEELTDLALAARPGAGGITLVPYFDGERTPNRPDATATLSGMTLRNTNRANFARAFVEGLLCSQRDCLELIRSLGAAIERILLIGGGAKSRAVRTLAPTVLGMEITCPATDEYVAIGAARQAAWVLSGVDDAPDWPISIDAVQTGTPTPQVYDAYVQARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTM7</accession>
    <name>B8DTM7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Metalloendopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BLA_1068</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269060.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29356">
        <property type="protein sequence ID" value="ACL29356"/>
        <property type="gene ID" value="BLA_1068"/>
    </dbReference>
    <dbReference type="GeneID" id="66532895"/>
    <dbReference type="KEGG" id="bla:BLA_1068"/>
    <dbReference type="HOGENOM" id="CLU_006187_7_2_11"/>
    <dbReference type="OMA" id="FGWAQVW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="PTHR11733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M13_N" evidence="9">
        <location>
            <begin position="20"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M13" evidence="8">
        <location>
            <begin position="461"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL29356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="693" mass="78285" checksum="2495AF01FC9D886E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTN2</accession>
    <name>B8DTN2_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.117</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Tetrahydrodipicolinate N-succinyltransferase</fullName>
            <shortName evidence="4">THDP succinyltransferase</shortName>
            <shortName evidence="4">THP succinyltransferase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Tetrahydropicolinate succinylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dapD</name>
        <name evidence="6" type="ordered locus">BLA_1073</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA = (S)-2-succinylamino-6-oxoheptanedioate + CoA</text>
            <dbReference type="Rhea" id="RHEA:17325"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15685"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="EC" id="2.3.1.117"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.117" evidence="4"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218769.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1073"/>
    <dbReference type="EnsemblBacteria" id="ACL29361">
        <property type="protein sequence ID" value="ACL29361"/>
        <property type="gene ID" value="BLA_1073"/>
    </dbReference>
    <dbReference type="GeneID" id="66532900"/>
    <dbReference type="KEGG" id="bla:BLA_1073"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1122"/>
    <dbReference type="HOGENOM" id="CLU_057490_1_0_11"/>
    <dbReference type="OMA" id="TVLDTWF"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008666">
        <property type="term" value="F:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02122">
        <property type="entry name" value="DapD_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019875">
        <property type="entry name" value="DapD_actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032784">
        <property type="entry name" value="THDPS_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038361">
        <property type="entry name" value="THDPS_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026586">
        <property type="entry name" value="Type2_DapD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14789">
        <property type="entry name" value="THDPS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03535">
        <property type="entry name" value="DapD_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="THDPS_M" evidence="5">
        <location>
            <begin position="103"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Succinyl-CoA binding" evidence="4">
        <location>
            <begin position="259"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-anhydride intermediate" evidence="4">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>ligand shared between trimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="327" mass="34321" checksum="8E25538A3692E601" modified="2009-03-03" version="1">MTQSRSAWGWGLASIDAAGNVLDVWYPKLTLGEAPAAKPNHGFGNLVHEGEDLRGVRRMPVFTVSRLDDPVVDAPDAYLRLHLLSMRLAKPNTLNLDGIFGALNNVVWTNYGPFAVDDFAQRRLAVMQGNAGAGMPGMRAEVNVLAIDKFPRMLDYVVPTGVRIGDGDRVRLGAYLSEGTTVMHAGFVNFNAGTLGTCMIEGRVSQGVVVGDGSDVGGGASIMGTLSGGGKLRNSIGEHSLLGANAGIGISLGDNCVVEAGLYVTAGTKIEVWDKEKAAAGVALDVVKGADLSGKNNILFIRNSLTGAIQARPRKTGIALNDALHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTN9</accession>
    <name>B8DTN9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable solute binding protein of ABC transporter system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BLA_1080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218778.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1080"/>
    <dbReference type="EnsemblBacteria" id="ACL29368">
        <property type="protein sequence ID" value="ACL29368"/>
        <property type="gene ID" value="BLA_1080"/>
    </dbReference>
    <dbReference type="GeneID" id="66532906"/>
    <dbReference type="KEGG" id="bla:BLA_1080"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1131"/>
    <dbReference type="HOGENOM" id="CLU_019602_18_1_11"/>
    <dbReference type="OMA" id="QPTKWDG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870490" evidence="5">
        <location>
            <begin position="29"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="6">
        <location>
            <begin position="70"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="309" mass="32487" checksum="5BB11A87D9F27130" modified="2009-03-03" version="1">MKNTWKATAAFAAIVLCAGMSACGTSDASDSGKSSGTSSSSAAASFDPSTVETDETIAALVPDYVKKDGKLTVGTDTTYAPAEFIGEDGKTAVGYDVDLTKAIAKVMGLEPETAVSEFDMIIPSIGSKYDIGISSFTVTPERQEAVDFVTYYKAGSTWVTQKGNPDKVDTKDLCGVKVAVQTGTTQEEELNKMNEQCKADGKKAIELQTFAKQTDVTTAVVNGKAAVFYADSPVAGYAIEQTDGALAPLGADEGVTEEGIIVKKGDKQMDEAVQKAVQKLMDDGTYQKILENWGVSSGAIDKAEINPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTP7</accession>
    <name>B8DTP7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218797.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29376">
        <property type="protein sequence ID" value="ACL29376"/>
        <property type="gene ID" value="BLA_1088"/>
    </dbReference>
    <dbReference type="GeneID" id="66532914"/>
    <dbReference type="KEGG" id="bla:BLA_1088"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1142"/>
    <dbReference type="HOGENOM" id="CLU_1902594_0_0_11"/>
    <dbReference type="OMA" id="SWGSRFY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="133" mass="14439" checksum="DA607518DFB14D50" modified="2009-03-03" version="1">MNAQIWYVVLLSVTVIAALIGTSIVLGQSKNGPGEDHYIDLDPQMQGEPYATPVIVGDDGVTRQKDIVHDIKQMPDDTAIVDVLYAGSKKGSKDDTKAEHMTMKKVDVRRLGLKPGTTVTLHVVDGAITLIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTR9</accession>
    <name>B8DTR9_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4065 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218824.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1110"/>
    <dbReference type="EnsemblBacteria" id="ACL29398">
        <property type="protein sequence ID" value="ACL29398"/>
        <property type="gene ID" value="BLA_1110"/>
    </dbReference>
    <dbReference type="GeneID" id="66532933"/>
    <dbReference type="KEGG" id="bla:BLA_1110"/>
    <dbReference type="HOGENOM" id="CLU_110683_1_1_11"/>
    <dbReference type="OMA" id="HFITIPR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025272">
        <property type="entry name" value="SocA_Panacea"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13274">
        <property type="entry name" value="DUF4065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4065" evidence="1">
        <location>
            <begin position="28"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="170" mass="18780" checksum="2C44A1C428668F9F" modified="2009-03-03" version="1">MLASDVARHIVAHYGDAWFLTNLKLNLLVYWCQVGALRDAGAPLFADEIAVGECGPVIPAIWAEYEAFGSRMIRLRDEWQVKALGENTESLVASVMRELGWLTAADLLNLSNHPDGAWNAAREQGYESISVSHIAGSADMRREVSERTLAACVDGVERKYPNALRLLEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTS5</accession>
    <name>B8DTS5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218833.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1116"/>
    <dbReference type="EnsemblBacteria" id="ACL29404">
        <property type="protein sequence ID" value="ACL29404"/>
        <property type="gene ID" value="BLA_1116"/>
    </dbReference>
    <dbReference type="GeneID" id="66532939"/>
    <dbReference type="KEGG" id="bla:BLA_1116"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1169"/>
    <dbReference type="HOGENOM" id="CLU_013985_13_0_11"/>
    <dbReference type="OMA" id="ELHGVYR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="174" mass="20085" checksum="DBAA920DDA6E0553" modified="2009-03-03" version="1">MQDATNRRFRHATMKDYPQMERIYAHARELMARNGNPTQWGNAFPKPQTVKEDIREHRAILLADTLGGKERILAQFALCPGLDPTYAKIEGAWLDNDSYVTIHRIASSGLVRHAARDCIEWCLKHYGNVRVDTHPNNKAMQHVLESCGFARCGLIQLIDRTEDTTRIAYQRHEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTS6</accession>
    <name>B8DTS6_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine racemase</fullName>
            <ecNumber evidence="3">5.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">alr</name>
        <name evidence="7" type="ordered locus">BLA_1117</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-alanine = D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20249"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="5.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alanine racemase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1117"/>
    <dbReference type="EnsemblBacteria" id="ACL29405">
        <property type="protein sequence ID" value="ACL29405"/>
        <property type="gene ID" value="BLA_1117"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1117"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1170"/>
    <dbReference type="HOGENOM" id="CLU_028393_0_0_11"/>
    <dbReference type="OMA" id="HMTHFSD"/>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030632">
        <property type="term" value="P:D-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01201">
        <property type="entry name" value="Ala_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020622">
        <property type="entry name" value="Ala_racemase_pyridoxalP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00395">
        <property type="entry name" value="ALANINE_RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_C" evidence="6">
        <location>
            <begin position="282"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for D-alanine" evidence="3">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for L-alanine" evidence="3">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3 4">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="452" mass="48919" checksum="12FD65CA18E2B5C6" modified="2009-03-03" version="1">MSVSALEEWQFSSEQGERNYNQALREYPAQVIVDLAALRDNMRHLVDITNREGGPTEVMGVVKADAYGHGLVPSALAALAGGATWLGVAQAREALALRNAGIGVDRARVLTWVNNPLHAPYDDLIAADVDLSVATLTAIQKIAEAARAVGKPARVHIKVDTGFGRNGFTLAQIDSAIDLLLPLVDEGVFEIVGQWSHLAVADAPAVGEFVEKTDEQIRVFEEFTSRLHARGIEPRIRHLANTAATLSRPEIHYDLVRPGVALYGYEADPAMGTPSKYELRPAMTLQAQLSSVKNVGAGEGLSYGRVYVTDEPTSAAIVPVGYADGIHRSASGFNEAGSKHVNKPGAPVRVMTRDGARIFHVSGRVCMDQFILDLHGDAENMGVHIGDTVELFGPGRGEDYLEPTADDWARAADTISYEIFTCLRNRVPRLYANAFEVLDETDLGKLDQSTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTU8</accession>
    <name>B8DTU8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218865.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29427">
        <property type="protein sequence ID" value="ACL29427"/>
        <property type="gene ID" value="BLA_1139"/>
    </dbReference>
    <dbReference type="GeneID" id="66532963"/>
    <dbReference type="KEGG" id="bla:BLA_1139"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1195"/>
    <dbReference type="HOGENOM" id="CLU_042784_0_0_11"/>
    <dbReference type="OMA" id="QFASNKM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd03408">
        <property type="entry name" value="SPFH_like_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033880">
        <property type="entry name" value="SPFH_YdjI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13421">
        <property type="entry name" value="Band_7_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band_7_1" evidence="2">
        <location>
            <begin position="116"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="SHOCT" evidence="1">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="410" mass="44228" checksum="68774E2A928168B1" modified="2009-03-03" version="1">MALIRAFAGALSGTFADQWLDIITVGQFDEHAVLMPGIYQETNRDRGSNTKHSEAVISNGSRIYVPENTAAFIFDQSGIENIITESGGYEYRTGGTDSVFAGNGIGKSIFEQIGERFKYGGEPVANKRIAFVNLREIRGIKFGTPAPLMYHDRFYQTDLEIRARGMMSVQVVNPLAFIRQFVPPNVDYISFDDPNTKSQILSEFMQSFSVALNSLSNEYRISALPSQANSIALAISGDSSNAGTWESRFGLHLVGIGIESIEFTDESRELVKQYSSNRMNLSAYENISQQASNIAAQQKIAEGVQQNGFGDMGGMMLGLGFAQGVNPMTGAMPGQSVPTQTNPAAAAAVAADAQGTVAQAAAQPPAAQGTQSAMSVTEQMEALKSLKELLDAGILTQEEFNVKKRQILGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTV5</accession>
    <name>B8DTV5_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rpsG</name>
        <name evidence="10" type="ordered locus">BLA_1146</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1146"/>
    <dbReference type="EnsemblBacteria" id="ACL29434">
        <property type="protein sequence ID" value="ACL29434"/>
        <property type="gene ID" value="BLA_1146"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1146"/>
    <dbReference type="HOGENOM" id="CLU_072226_1_1_11"/>
    <dbReference type="OMA" id="NVMPHVE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_S7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_S7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01029">
        <property type="entry name" value="rpsG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="9">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL29434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="138" mass="15756" checksum="E533CCA8CEFFF724" modified="2009-03-03" version="1">MSRKGPSKKHQVLPDPIYGSIVVAQLINKILLDGKKSIAEDIVYSALDMVKDKTDQEPVAVLKRALDNIRPSLEVRSRRVGGATYQVPVEVKPARANTLSLRWLTDFSRARREKTMGRASRKRDPRRVQRPWRIRQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTW9</accession>
    <name>B8DTW9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Possible cyclopropane-fatty-acyl-phospholipid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1160"/>
    <dbReference type="EnsemblBacteria" id="ACL29448">
        <property type="protein sequence ID" value="ACL29448"/>
        <property type="gene ID" value="BLA_1160"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1160"/>
    <dbReference type="HOGENOM" id="CLU_026434_6_2_11"/>
    <dbReference type="OMA" id="QAEWAQK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="Mycolic_cyclopropane_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR003085-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="427" mass="47834" checksum="AC8E746E20FD850C" modified="2009-03-03" version="1">MAAMTVAQMIELFLKPGAPVHIESFDGSSYGSDDAPLTLQVKNSRAIYYMVNAPSELGLARAYLQGDIDSPQLVPGNPYALFKELVPLKSYLRTPNPAQLAKALASVASHGFHRPAPPDIEGPSRARRISEGLLPHSKAGDEATVSYHYDQSNEFYSMFLGPSMTYTCAVFDSPLMSLEAAQKNKIDLVLDKLALQPGERLLDIGCGWGSMVIEAAKRGIKALGVTLSEEQVEWAQRWIKDEGLEDLAEVRLMDYRDVPEGDFDGICSIGMMEHVGHKHYPSYFKEIYAKLKPGAKLLNHQITRCNSHQGKKAGQFIDRYIFPDGELSSPAEIEMVIQDTGFEVINQENLRQHYALTLHRWNENLVAHWDDAVKLVGEPKARLWGLYMAGCAFNFEMNNIQVHQFLAIKPNDEGTDTYPLRPWWPNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU14</accession>
    <name>B8DU14_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable efflux-type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BLA_1205</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218138.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1205"/>
    <dbReference type="EnsemblBacteria" id="ACL29493">
        <property type="protein sequence ID" value="ACL29493"/>
        <property type="gene ID" value="BLA_1205"/>
    </dbReference>
    <dbReference type="GeneID" id="66533030"/>
    <dbReference type="KEGG" id="bla:BLA_1205"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1267"/>
    <dbReference type="HOGENOM" id="CLU_000960_28_0_11"/>
    <dbReference type="OMA" id="GGWISTS"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="30"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="500" mass="52499" checksum="73BCBD7FC51A64F2" modified="2009-03-03" version="1">MTTRPTQGGKKRIANPAANDDRISPKLIGSIVSVGSLAFIGILTETVMTVLFPELMVEFSVNTATVQWITTIYLLSVGVTMPVSSYLKRRFTMKSVFVAAVALAVVGSFIMIVGTSFPVIIVARVIQGVGSGIATPLMINIILEQSPRSKVGRLMGVGSLVITVAPAIGPTVGGAVASIWPWRSIFVIVIPVIVLISLPIGLKCITQTKPTEAVSLNPLQFLAIIVGLAGMILSLNQGGVAVSEGVSGEPWGRSAAIAIVSLAVGVAALVFFVWSSRRSFSPLIRLGWLKDKVVMLHLIPYTLLPMVGIGFGYVITNLAQLSLGTSALVAGMLVLPGALIGAFFAPVGGMLYDKHGPTKPILGAFACCFGALVLFLGFSMYLTSVLMASFYFIFGVGYALGFSNIMTDAISGIHHEFTPDGNAVFNTALQFGGAAGTTLFSTILAIAQAGHGAEGTPVYRHATAVGGTWTFAVMLAIVAVSWIMLARAFALNKARMEQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU19</accession>
    <name>B8DU19_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619967.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1210"/>
    <dbReference type="EnsemblBacteria" id="ACL29498">
        <property type="protein sequence ID" value="ACL29498"/>
        <property type="gene ID" value="BLA_1210"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1210"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1272"/>
    <dbReference type="HOGENOM" id="CLU_078717_1_0_11"/>
    <dbReference type="OMA" id="YCEEYCS"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="238" mass="27587" checksum="348D50C3FA61C4CD" modified="2009-03-03" version="1">MNDSISYRTLQRTDYPALTKMLCETWHKQDPQMDEDLQMKLAQIDLEYCLARTTTAEVAVRDGEVVGAVLGRIDAQETRKGINQHHRSVMKIMGPLFFNKSAHQALKNMLNAEKADRQMIKQAKKDGHAYDGEIVLFIVREDMRGQGIGQHLFDWMLNEFKVNNVEHYFLYTDTDCDYGFYEDRGMVRRMEMPMEPHTPKEDTEAHQEADYLDNHLHALMFDNETSPANEGVNPLGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU21</accession>
    <name>B8DU21_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29500">
        <property type="protein sequence ID" value="ACL29500"/>
        <property type="gene ID" value="BLA_1212"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1212"/>
    <dbReference type="HOGENOM" id="CLU_120384_1_0_11"/>
    <dbReference type="OMA" id="FAVITIC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="YccF" evidence="2">
        <location>
            <begin position="3"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="YccF" evidence="2">
        <location>
            <begin position="52"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="105" mass="11347" checksum="6A5339424FB3A9C0" modified="2009-03-03" version="1">MEIAFAWFVVGLVLCVTIVGIPLGVQSFKMAQLTLTPFGQHVVYGGSVGSLLLNIVWVVLVGWWMALGYLIAGVLNCITVIGVPFGIQSFKMCKLALWPFGTTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU36</accession>
    <name>B8DU36_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619972.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1227"/>
    <dbReference type="EnsemblBacteria" id="ACL29515">
        <property type="protein sequence ID" value="ACL29515"/>
        <property type="gene ID" value="BLA_1227"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1227"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1289"/>
    <dbReference type="HOGENOM" id="CLU_089257_0_0_11"/>
    <dbReference type="OMA" id="GDLMSNM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025445">
        <property type="entry name" value="DUF4191"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13829">
        <property type="entry name" value="DUF4191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="262" mass="29728" checksum="1E8F3EF47FEEF7A4" modified="2009-03-03" version="1">MAQQEKSEKPKKRGMFEQIVTIYKFTAAEDKALPWITGAVFAAPIVVGIICGIVFHWGWVSWITLMILAVMIGLLLFTIVLTRRADNVGYKQMEGKSGAAISILGNMKRAGFDFPQEPVWVDPRTRDAVWRGTGYQGIYLIGEGNYGRVMQAMDRQEKQIKGVTAGSHIPVYRICVGDGPKQVRLKDLRNTVLRKKTYVPNNYTNPIMRKLHPRHRFALSKPQLITLNDRLHTLQRRSGMGIPKGMDPMKTHKVSRRAIRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU37</accession>
    <name>B8DU37_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Dihydrolipoyl dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">lpdA</name>
        <name evidence="12" type="ordered locus">BLA_1228</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AD011</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218108.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1228"/>
    <dbReference type="EnsemblBacteria" id="ACL29516">
        <property type="protein sequence ID" value="ACL29516"/>
        <property type="gene ID" value="BLA_1228"/>
    </dbReference>
    <dbReference type="GeneID" id="66533052"/>
    <dbReference type="KEGG" id="bla:BLA_1228"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1290"/>
    <dbReference type="HOGENOM" id="CLU_016755_0_2_11"/>
    <dbReference type="OMA" id="HMVGDRM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016668">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 9" id="KW-0274">FAD</keyword>
    <keyword evidence="2 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="11">
        <location>
            <begin position="6"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="10">
        <location>
            <begin position="366"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="471"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="162"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="198"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="8">
        <location>
            <begin position="44"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACL29516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="493" mass="52373" checksum="AF50811A477C82FB" modified="2009-03-03" version="1">MTSEHYDVVIIGAGPGGYTVALRSAELGKSVLLVERDDVVGGTCLNRGCIPSKALITATRTIDTIHRGEQIGIDCELQEIDFGKLRAFRDGTVSTMRDGLLALLTFRGVHMVQGIASVVEDGHVHVRPAQGGQTIRIRTADGDFKDGGQSLDVTAGDVVIATGSRPKPLDVAPFNHVLIDSTRALALNSFPHSAVVIGSGATALEFASMWNSAGADVTLIMRGDIVLSRSDRRAAKILMRELKRQGITIVTNAAITAVDTGENLGVTVHYTDADGNGQEVFAEWALAAIGRVPNTDGAWFAKASIELDENGLVKTDAYGRTSREHVWALGDITPGHQLAHRAYQQGYVVAETIAGLDPSPVDEYTIPTVVFSNPEFASVGYTLREAKADTELVDVTETLIPVMSNARMLMSGASGSVSVVSGKKSADQSDDVHVLGVHIVSPDASDLIAEAQQIIGNHVPLSAAARNIHPHPTFSEMLGETLLKADGRPLHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU38</accession>
    <name>B8DU38_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1229"/>
    <dbReference type="EnsemblBacteria" id="ACL29517">
        <property type="protein sequence ID" value="ACL29517"/>
        <property type="gene ID" value="BLA_1229"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1229"/>
    <dbReference type="HOGENOM" id="CLU_1072250_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021403">
        <property type="entry name" value="DUF3043"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11241">
        <property type="entry name" value="DUF3043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="259" mass="29054" checksum="BAD621BF7671346E" modified="2009-03-03" version="1">MALFKKKETESKQDVAQAPAEPTVGKGRPTPKRKDAEARNLRPLVPENTKEQRKLAKQKLRERENREYEAMRTGDLNNMPKAERLPWRIYTRDYIDARFNIGEYFIPVALVMLVASVIFTVIFPSPLVSIIIMTLLYLYLFAIVIDEVVMWRSSRNCSSPSTASSRWHAACAPDPMRGAVPSSSAAGACPNHAMPSAGISRSSRTLSETYKEGNAMRSPPSLRPALHMPTESVFQRDPPKHLLHSCGMRAGRVICMQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU40</accession>
    <name>B8DU40_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exodeoxyribonuclease V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">recD</name>
        <name evidence="3" type="ordered locus">BLA_1231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218104.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1231"/>
    <dbReference type="EnsemblBacteria" id="ACL29519">
        <property type="protein sequence ID" value="ACL29519"/>
        <property type="gene ID" value="BLA_1231"/>
    </dbReference>
    <dbReference type="GeneID" id="66533055"/>
    <dbReference type="KEGG" id="bla:BLA_1231"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1294"/>
    <dbReference type="HOGENOM" id="CLU_703330_0_0_11"/>
    <dbReference type="OMA" id="CTYIARS"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="188"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="385" mass="42855" checksum="61C1D72789D44AFB" modified="2009-03-03" version="1">MRWVGADASGCTMQKRLKNIAHPFLAFIIAAFSLVFECDVWLFTPPKQWWFISVLMLAQALAISCYWSPVWCSVALLLLNGVGEYAISGYAQFTSYFMFLAVILICYKTSNRIAAALCLLMMSYTCLETMIRPGSFTGYGCLAFCMIYAVASTIGRYMAWEQRRMERMRESVMVESRLRQLEANQYLAAYLHDALSQELALISMETQLHAVDKSVPDEERWRRVSDYTQNALADLRGIITQLRGDGDFKKNGDEPENVVALLRREAAAGDRLLHDHGFSGETVLESAQDANMHSSELCGLLSLICHELYTNMLKHAETARPYHVSISLSSSHVCIRYANGIGEQSVAGGGNGLRSLQSLITSMGGDFSHDADDGGWSGTVEIPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU57</accession>
    <name>B8DU57_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetylornithine aminotransferase</fullName>
            <shortName evidence="2">ACOAT</shortName>
            <ecNumber evidence="2">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">argD</name>
        <name evidence="4" type="ordered locus">BLA_1248</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + N(2)-acetyl-L-ornithine = L-glutamate + N-acetyl-L-glutamate 5-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:18049"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.6.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="2">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218078.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1248"/>
    <dbReference type="EnsemblBacteria" id="ACL29536">
        <property type="protein sequence ID" value="ACL29536"/>
        <property type="gene ID" value="BLA_1248"/>
    </dbReference>
    <dbReference type="GeneID" id="66533070"/>
    <dbReference type="KEGG" id="bla:BLA_1248"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1311"/>
    <dbReference type="HOGENOM" id="CLU_016922_10_1_11"/>
    <dbReference type="OMA" id="PFMVPTY"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="116"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="238"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="417" mass="44506" checksum="8EED53E4485D3EA6" modified="2009-03-03" version="1">MTSEQIDLTHDTELIGEYEQVHMHVFGTPLRVLDHGQGTHVWDVDGNEYLDFLAGIAVNSIGYAHPAWIEAVSAQAAQVAHVSNYFATRPQISLAAKLVELAGAPQGSHVYFGNSGAEANEAALKLAKLYGRSLGADKPYRIIALEHGFHGRTMGALSATWKPAIREPFQPLVPNFEFVPANDLDAMRAAFEATDSGPVASVIMELIQGEAGVLPLDPEFVRGVRSLCDEHHAKLIVDEVQTGMGRTGKWFAFQRDDLGGITPDMVTFAKGVAGGFPMGGMIAFGEELSNLFSPGTHGSTFAGNPLGAAAGLATIGVIEREDLLVNAEARGEQLRRQIRACGNPLFESVRGRGLLNAIVLTHPCAHAAMDWALEHGLIINAVAPNALRLAPPLVVSENDVDEAVHVLAAIPSDLPND</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU59</accession>
    <name>B8DU59_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Arginine repressor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">argR</name>
        <name evidence="13" type="ordered locus">BLA_1250</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Regulates arginine biosynthesis genes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-arginine biosynthesis [regulation].</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the ArgR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218074.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1250"/>
    <dbReference type="EnsemblBacteria" id="ACL29538">
        <property type="protein sequence ID" value="ACL29538"/>
        <property type="gene ID" value="BLA_1250"/>
    </dbReference>
    <dbReference type="GeneID" id="66533072"/>
    <dbReference type="KEGG" id="bla:BLA_1250"/>
    <dbReference type="HOGENOM" id="CLU_097103_1_1_11"/>
    <dbReference type="OMA" id="IMGTICG"/>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034618">
        <property type="term" value="F:arginine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00173">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001669">
        <property type="entry name" value="Arg_repress"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020899">
        <property type="entry name" value="Arg_repress_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036251">
        <property type="entry name" value="Arg_repress_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020900">
        <property type="entry name" value="Arg_repress_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34471">
        <property type="entry name" value="PTHR34471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01316">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02863">
        <property type="entry name" value="Arg_repressor_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01467">
        <property type="entry name" value="ARGREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55252">
        <property type="entry name" value="SSF55252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Arg_repressor" evidence="11">
        <location>
            <begin position="21"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Arg_repressor_C" evidence="12">
        <location>
            <begin position="111"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACL29538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="181" mass="18904" checksum="8C510215EAE7A992" modified="2009-03-03" version="1">MSEQTGSESSNGASGVGRPSTRAARLQMVRQLLADNVVTSQAQLSELLAREGFPVTQATMSRDLDEVNAAKTRLADGTIAYAVADQVPLATVPESNGQGRGEQQLAKILTGLVVSVAHASNFVIVHTPAGAAQYVASGIDKHSIDGVLGTIAGDDTILIICSDDTTAGRRAEWMLRISSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU62</accession>
    <name>B8DU62_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Diacetyl reductase ((S)-acetoin forming)</fullName>
            <ecNumber evidence="3">1.1.1.304</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">butA</name>
        <name evidence="4" type="ordered locus">BLA_1253</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-acetoin + NAD(+) = diacetyl + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:27286"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15687"/>
            <dbReference type="ChEBI" id="CHEBI:16583"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.304"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.304" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218071.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1253"/>
    <dbReference type="EnsemblBacteria" id="ACL29541">
        <property type="protein sequence ID" value="ACL29541"/>
        <property type="gene ID" value="BLA_1253"/>
    </dbReference>
    <dbReference type="GeneID" id="66533075"/>
    <dbReference type="KEGG" id="bla:BLA_1253"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1316"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_11"/>
    <dbReference type="OMA" id="MFEVNVY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052588">
        <property type="term" value="F:diacetyl reductase ((S)-acetoin forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045150">
        <property type="term" value="P:acetoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014007">
        <property type="entry name" value="23BDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02415">
        <property type="entry name" value="23BDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="261" mass="28409" checksum="C6D818D75364E3F8" modified="2009-03-03" version="1">MTDIRVAIVTGAARGIGRGIAVKLAKDGFDVAVADLEGQRQEAEETIHRIEQEGRRAFFRPTDVSQRDQVFGLVDDTVNELGTLDAMINNAGICQIKPMLDVTQEELETIYRINLFGMVYGVQAAAKKMIKLGKKTGHIVSASSIAGFEGFPILSAYSSTKFAVRGFTQAAAQELAPYNITVNGYAPGIVDTPMWTFIDEEMSKLNGKPLGQNFKDMVDTIALKRCETPDDVAGVVSFLVSDNARYVTGQTVIVDGGMQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU68</accession>
    <name>B8DU68_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BLA_1259</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619983.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1259"/>
    <dbReference type="EnsemblBacteria" id="ACL29547">
        <property type="protein sequence ID" value="ACL29547"/>
        <property type="gene ID" value="BLA_1259"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1259"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1322"/>
    <dbReference type="HOGENOM" id="CLU_026429_0_0_11"/>
    <dbReference type="OMA" id="MFIGSAP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="487" mass="52828" checksum="FA3FFC7EB2D411B9" modified="2009-03-03" version="1">MANLLFDESASNSETSKGFGWWFSGDTFERNAYEERNPHSRSLSYRLNSHPGRLTIIYFLALITVSTSLLCLPIATQPGKKTSFSTAFFTAVSALSTCGISVVNTTDHWTIFGQVVLIFSVQMGGLGVMTFASLIALAVNHHLKAMQRLLAANELGTNKLSEIRGVLQVVLMTTLVIEVVTFFALFPGLLSVNKGNVGRTLWESLFFAVMSYNNAGFTPDGAGLYVNNWAVGLPIMMSAFCGTLGFPVLLNIFRTARMHKSPKHWSLHTKITMIMTFAIVFMSLIWFLAVEWDNPVLFKDGDVDTRMRRAMVAAVMPRSSGFDLSWVPGVKECTKVFMSIVMFIGGGSTSTAGGIRVTTLAVILLVCKAAFTGHTDVNAFHKRVPQHVIMTAISITASCVALVFIASVALMLITDSSLSHAMFDTCSAFGLGGYTVGVAQENNPASLYVLAAAMVVGRLGPMTLAYAVSRPKELDVVRYPEGQIVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU77</accession>
    <name>B8DU77_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribose-phosphate pyrophosphokinase</fullName>
            <shortName evidence="6">RPPK</shortName>
            <ecNumber evidence="6">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">5-phospho-D-ribosyl alpha-1-diphosphate</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl pyrophosphate synthase</fullName>
            <shortName evidence="6">P-Rib-PP synthase</shortName>
            <shortName evidence="6">PRPP synthase</shortName>
            <shortName evidence="6">PRPPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">kprS</name>
        <name evidence="6" type="synonym">prs</name>
        <name evidence="8" type="ordered locus">BLA_1268</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="6"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619986.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1268"/>
    <dbReference type="EnsemblBacteria" id="ACL29556">
        <property type="protein sequence ID" value="ACL29556"/>
        <property type="gene ID" value="BLA_1268"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1268"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1331"/>
    <dbReference type="HOGENOM" id="CLU_033546_2_0_11"/>
    <dbReference type="OMA" id="FGWARQD"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_B">
        <property type="entry name" value="RibP_PPkinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037515">
        <property type="entry name" value="Rib-P_diPkinase_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="7">
        <location>
            <begin position="19"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ribose-5-phosphate binding" evidence="6">
        <location>
            <begin position="237"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="46"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="105"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="339" mass="36783" checksum="F0573D3ED50B6A71" modified="2009-03-03" version="1">MSAILEGKPDKNLILVQAGRIPSWATDVADQLGIDVLETTAYDFANGEMYVRYTESVRGADVFVLQSHCTPVNKSIMEQLIMIDALKRASARSITAVCPLLGYSRQDKKHRGREPISCRLVFDLLRTAGADRVMSVDLHAAQTQGFFDGPVDHLIAMPVLVDYIRDRFDGHLDNVTVVSPDAGRIRVAEQWAQRLGGGPLAFVHKTRDITRPNQAKANRVVGDVKGKDCVLVDDLIDTAGTIAGACQVLREAGARSVTVVATHGVLSGPAVDRLKSCGAREVVLTDTVPIPEEKRWDGLTVLSIAPLLSSAIKAVFEDGSVAELFDTYPEHHGQGFLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU91</accession>
    <name>B8DU91_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal-protein-alanine acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rimI</name>
        <name evidence="2" type="ordered locus">BLA_1283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218033.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1283"/>
    <dbReference type="EnsemblBacteria" id="ACL29570">
        <property type="protein sequence ID" value="ACL29570"/>
        <property type="gene ID" value="BLA_1283"/>
    </dbReference>
    <dbReference type="GeneID" id="66533108"/>
    <dbReference type="KEGG" id="bla:BLA_1283"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1345"/>
    <dbReference type="HOGENOM" id="CLU_013985_23_3_11"/>
    <dbReference type="OMA" id="FEPIGFR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006474">
        <property type="term" value="P:N-terminal protein amino acid acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006464">
        <property type="entry name" value="AcTrfase_RimI/Ard1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01575">
        <property type="entry name" value="rimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="165" mass="18724" checksum="202FF2CFFA009CA0" modified="2009-03-03" version="1">MIVDANTLDRATVCSQIAKMELQLFGKGAWSNTLIDEELSAPHRSYYVNVDDQGTIDAYAGLWYDGYDAQIMTIGVSPERQRQGIATQLINQLIAKANELHAERMLLEVRVDNEPALTLYRHFGFETMGIRKRYYQPENKDAYTMSLTLRDSRPAGFAIPLNTQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU98</accession>
    <name>B8DU98_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="8">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">BLA_1290</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8 11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8 11">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="8"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218022.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1290"/>
    <dbReference type="EnsemblBacteria" id="ACL29577">
        <property type="protein sequence ID" value="ACL29577"/>
        <property type="gene ID" value="BLA_1290"/>
    </dbReference>
    <dbReference type="GeneID" id="66533116"/>
    <dbReference type="KEGG" id="bla:BLA_1290"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1352"/>
    <dbReference type="HOGENOM" id="CLU_023296_1_1_11"/>
    <dbReference type="OMA" id="HGTVQRH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="PTHR11822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 12" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Iso_dh" evidence="13">
        <location>
            <begin position="9"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="94"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="75"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="309"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="9">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="9">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACL29577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="407" mass="45770" checksum="11CB61C66181E73C" modified="2009-03-03" version="1">MAKIKVEGKVVELDGDEMTRVIWKDIKDRLILPYLDIDLDYYDLGIENRDATDDQVTIDAAEAIKREHVGVKCATITPDEARVEEFGLKKMWKSPNGTIRNILGGTIFREPIVIDNIPRLVPGWTKPIVVARHAFGDQYKATDFKVPTSGTLTVTFTPNDGSGPIEHVVFDYPGSGVAQVQYNLDESIRGFARACFNYGLLRHYPVYLSTKNTILKAYDGEFKDIFAEVFETEYKQRYEQEGLTYEHRLIDDMVASSLKWHGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTPDGQTVEAEAAHGTVTRHYRLWQKGEKTSTNPIASIYAWTGGLKHRAKLDGTPQVANFAETLEQTIISTVEGGQMTKDLAILIDPSHEWLDTEQFMNALDENLQRNLAEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUA0</accession>
    <name>B8DUA0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218016.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29579">
        <property type="protein sequence ID" value="ACL29579"/>
        <property type="gene ID" value="BLA_1292"/>
    </dbReference>
    <dbReference type="GeneID" id="66533118"/>
    <dbReference type="KEGG" id="bla:BLA_1292"/>
    <dbReference type="HOGENOM" id="CLU_1406335_0_0_11"/>
    <dbReference type="OMA" id="YLLGTHM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="193" mass="21696" checksum="7EA3C9637BF4519A" modified="2009-03-03" version="1">MHTPSNPSNTKPHAGNARQPIDIPPLKEELETCPPDVDMHIERTPLPVHSGMLSRNHSLCPVRFRIRSCVNVELLPITAYGISERAFKICCIAFEVVRGRVGVQALRGMVTTTCCERLELMRDLMKSATSSRVDLHSKRFYGQPMPVLIDGTAVSPMRFEITIEVRVGSLQYWVNMVLDLRGSAWICTYLDMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUB3</accession>
    <name>B8DUB3_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoribosyl-AMP cyclohydrolase</fullName>
            <shortName evidence="7">PRA-CH</shortName>
            <ecNumber evidence="7">3.5.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">hisI</name>
        <name evidence="9" type="ordered locus">BLA_1305</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PRA-CH family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="7"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269090.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1305"/>
    <dbReference type="EnsemblBacteria" id="ACL29592">
        <property type="protein sequence ID" value="ACL29592"/>
        <property type="gene ID" value="BLA_1305"/>
    </dbReference>
    <dbReference type="GeneID" id="66533131"/>
    <dbReference type="KEGG" id="bla:BLA_1305"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1367"/>
    <dbReference type="HOGENOM" id="CLU_048577_5_1_11"/>
    <dbReference type="OMA" id="TGYRSCF"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01021">
        <property type="entry name" value="HisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026660">
        <property type="entry name" value="PRA-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="SSF141734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PRA-CH" evidence="8">
        <location>
            <begin position="45"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL29592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="137" mass="15575" checksum="F8854EA3BCFB4518" modified="2009-03-03" version="1">MSYESEIVYDNTKTLDPRIKDRLKYDDKGLVCAVIQQYDTHEVLMVGYMDDEALRRTLTTGRVTFWSRSRQEYWCKGDTSGHVQYVKGLSLDCDGDAILVEVDQVGAACHTGKRSCFDEGGPLPVVMGEREPREETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUH9</accession>
    <name>B8DUH9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29658">
        <property type="protein sequence ID" value="ACL29658"/>
        <property type="gene ID" value="BLA_1373"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1373"/>
    <dbReference type="HOGENOM" id="CLU_061737_0_0_11"/>
    <dbReference type="OMA" id="YVFSIWG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="305" mass="34066" checksum="CDE3A95986C0EF1A" modified="2009-03-03" version="1">MEPKSSSQRSKQKVRHDIEMICAWVSFAALVVCNVLAQTGVMGRMVKPQHSEAFTWFVPARYTDLIWAVIFVFAAVWLVRLGNDKHRARNLGKIPASLLGILFIAACVLQIAWLFCFHAVNYPATITLVFASTIVIWVLWFFSRRHDRTLWGWVPFSLWGSWLGIETITDIARAVSYYLSKDGSLSAFGQMISTIILALLLLAVACAMRWYMGDWVFGLCVLWSVLGVAIRIMDTSKITAVIVIIAESIAAALMYLPWRHLTGRLNSVDALSSAHAGAVDEQGRKSVESDGEPQSTDYPGAQEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUI3</accession>
    <name>B8DUI3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BLA_1377</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1377"/>
    <dbReference type="EnsemblBacteria" id="ACL29662">
        <property type="protein sequence ID" value="ACL29662"/>
        <property type="gene ID" value="BLA_1377"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1377"/>
    <dbReference type="HOGENOM" id="CLU_021126_0_1_11"/>
    <dbReference type="OMA" id="HMRTLHL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040177">
        <property type="entry name" value="SLC30A9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414">
        <property type="entry name" value="PTHR13414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="356" mass="39087" checksum="852C30A9521E29FF" modified="2009-03-03" version="1">MSTSTQTDMAQPRHIPPKQDNPIVQEERKHEGAAVKAALAANVGVAIAKLAAWAFTQSSAMLSESVHSIADCTNEIVLMAGGRVARKKRKNPQHPFGWFRVKYLASFVVATLLFFVGGFFSTSEAVKKITEVLSDQSARVANRGELVVALIVVVISACLEGYGLHQSVKESNERMRHTGMPHMGIYRFWRVTKSADLASVIMEDTLALIGLVFAFLGIGLAICTGDELYDALGGMFVGIVLIVGSLLLAYKTGSLLIGESVSPLTQERIIKAVEGTEGVEDLLNMQSVHMSEDNILLCLKVQTSKFDRDYDVTTVNKIEDAVRTAMPWYNWEIYVEPDMMRETQAGTPDEPVDLME</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUJ0</accession>
    <name>B8DUJ0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Possible alpha beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217900.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1384"/>
    <dbReference type="EnsemblBacteria" id="ACL29669">
        <property type="protein sequence ID" value="ACL29669"/>
        <property type="gene ID" value="BLA_1384"/>
    </dbReference>
    <dbReference type="GeneID" id="66533214"/>
    <dbReference type="KEGG" id="bla:BLA_1384"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1448"/>
    <dbReference type="HOGENOM" id="CLU_045011_9_1_11"/>
    <dbReference type="OMA" id="LLEWNCR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="212" mass="24038" checksum="9CF3401EC23494BC" modified="2009-03-03" version="1">MGENQTTNRAVSDVVFDFCGVLIDWQCHAALDGVYPEQLVADICADNDPYGFFHYEDLMDGGADFADVLELVRAEQGDEIAEVYRYYIEHYGDALPQLVDGAEELLTELCEQGVHVWGLTNWSADTFHFAFEKYPQLQRLLSGTVVSGIEKLRKPNADIYELAQSRFNLEPQTTVFFDDTQRNVDGAKSVGWHAFRFSDVAQARRDLLSLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUL8</accession>
    <name>B8DUL8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BLA_1412</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0126 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217862.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1412"/>
    <dbReference type="EnsemblBacteria" id="ACL29697">
        <property type="protein sequence ID" value="ACL29697"/>
        <property type="gene ID" value="BLA_1412"/>
    </dbReference>
    <dbReference type="GeneID" id="66533241"/>
    <dbReference type="KEGG" id="bla:BLA_1412"/>
    <dbReference type="HOGENOM" id="CLU_064906_1_0_11"/>
    <dbReference type="OMA" id="MPKFDYQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005115">
        <property type="entry name" value="Gly_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03458">
        <property type="entry name" value="Gly_transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="9">
        <location>
            <begin position="14"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="9">
        <location>
            <begin position="100"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="226"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL29697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="261" mass="27858" checksum="D78C212C7BCC5FFB" modified="2009-03-03" version="1">MEIALQSTPFFQAVEYLAIFSCGMAGGLTAVRKRYDVSSIIIIAWITALGGGIIRDVLLGALPPVGISDMGSVLTAFAAGAVTAVVHPEVDKLKWSMITIDALALGLFAVNGTSKALLYNTSGMTAVFLGTFTAMGGGVIRDMLVNEVPMVVRDPHLYVVPAVLGSIFTVWVWRAHTGRLIGDNTEMLLDVVIVLVVIVLRICSVKFNIRLPGAVQRHRVHLPATLLRGERAQTDTDGQRRKAAPDSKDAPGPRRGDPASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUN6</accession>
    <name>B8DUN6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SUF system FeS assembly protein, NifU family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217841.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1430"/>
    <dbReference type="EnsemblBacteria" id="ACL29715">
        <property type="protein sequence ID" value="ACL29715"/>
        <property type="gene ID" value="BLA_1430"/>
    </dbReference>
    <dbReference type="GeneID" id="66533260"/>
    <dbReference type="KEGG" id="bla:BLA_1430"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1494"/>
    <dbReference type="HOGENOM" id="CLU_079283_4_0_11"/>
    <dbReference type="OMA" id="MKLDSMY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="12"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="191" mass="20583" checksum="B68B42238EF5CDAB" modified="2009-03-03" version="1">MADLGSQELEQMYQEVILDASRHPHGRGTLTSEGDPAAIGGEATVTAVHESCSAARSHQFNPTCGDEVTVHVEVSDSEPHRIESVVWDGQGCSISQASLSIMVNLVEGKTVDEAMELFGQFHKLMESRGAGLDDEQAEDALGDAAVFQGVSKYPMRIKCALLGWEGLRDSLAKALASQHSEATEHDEMKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUP7</accession>
    <name>B8DUP7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217828.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29726">
        <property type="protein sequence ID" value="ACL29726"/>
        <property type="gene ID" value="BLA_1442"/>
    </dbReference>
    <dbReference type="GeneID" id="66533272"/>
    <dbReference type="KEGG" id="bla:BLA_1442"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1508"/>
    <dbReference type="HOGENOM" id="CLU_691998_0_0_11"/>
    <dbReference type="OMA" id="HTSGRYW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="400" mass="44605" checksum="47034DA4674A93CE" modified="2009-03-03" version="1">MIMARRTMREHDVVIVDYSDLNAIAIVTDRSEDPKITQGIGGPGVPAFRLQYVAGLTMVEDKVEPAVGFIWLNDDPEHISIVGVNGCLLPSTFYGVDMVQAFRDIGVDCGDGTESDDASSKLISDFISNEPLDQVLSADAWRLDDYPPRRRLDLLARAQKTLEFTDGAREKAADEVATARQAFENACAVLRKRLVWAVWCVAIIPGAYFAIAACRADVETAGRLRGIITLLMAIVFGVLITSAIREGRLARKSRSTLLAALAAQGVQENFTYAQELKIEPILRMIPQEYRDGTQIGAIIELLTSPATPDFAQATTQWDALLHQYKMEQLHTRQGEQSDLRARYEQDAETIRQTDLSDAWNEFDAQEARTQSVRQRNDELRLAIQRRGLEPDTILEKLGHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUS1</accession>
    <name>B8DUS1_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA_edit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PRORSD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217795.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29750">
        <property type="protein sequence ID" value="ACL29750"/>
        <property type="gene ID" value="BLA_1468"/>
    </dbReference>
    <dbReference type="GeneID" id="66533298"/>
    <dbReference type="KEGG" id="bla:BLA_1468"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1536"/>
    <dbReference type="HOGENOM" id="CLU_104635_0_0_11"/>
    <dbReference type="OMA" id="CHPLSND"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040285">
        <property type="entry name" value="ProX/PRXD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31423">
        <property type="entry name" value="PTHR31423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="2">
        <location>
            <begin position="24"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="159" mass="17607" checksum="5BCCEBC7A67ADD60" modified="2009-03-03" version="1">MLGTTVTLYNTLDELGIDYTEVTHPAVTTMEAAQFVRTLIDGTPIKNLFLTNRKGNYYLVLMSEDRRADLKALAQIIGTGRLSFANADDLRRVLNLEPGSVTPLALINDADQQVEVLVDTALAGQRLLMHPNTNTKAMSPEYGDLLRFIGHTGHGYRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUT5</accession>
    <name>B8DUT5_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="9">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">guaA</name>
        <name evidence="12" type="ordered locus">BLA_1482</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="9"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217770.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1482"/>
    <dbReference type="MEROPS" id="C26.957"/>
    <dbReference type="EnsemblBacteria" id="ACL29764">
        <property type="protein sequence ID" value="ACL29764"/>
        <property type="gene ID" value="BLA_1482"/>
    </dbReference>
    <dbReference type="GeneID" id="66533312"/>
    <dbReference type="KEGG" id="bla:BLA_1482"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1551"/>
    <dbReference type="HOGENOM" id="CLU_014340_0_5_11"/>
    <dbReference type="OMA" id="KRKIIGH"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9 12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 9 10" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="11">
        <location>
            <begin position="196"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="223"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACL29764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="520" mass="56023" checksum="19750AFC74CA9A26" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUU5</accession>
    <name>B8DUU5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_1492</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217756.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1492"/>
    <dbReference type="EnsemblBacteria" id="ACL29774">
        <property type="protein sequence ID" value="ACL29774"/>
        <property type="gene ID" value="BLA_1492"/>
    </dbReference>
    <dbReference type="GeneID" id="66533323"/>
    <dbReference type="KEGG" id="bla:BLA_1492"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1561"/>
    <dbReference type="HOGENOM" id="CLU_000445_65_0_11"/>
    <dbReference type="OMA" id="QKTSMDR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="39"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="ANTAR" evidence="5">
        <location>
            <begin position="180"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="159"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="252" mass="27950" checksum="7EBDA3DBD0D20C1C" modified="2009-03-03" version="1">MSNEEQESITEEPTVDNAADAIEVADAQVAKKEAKRNPTVVVAEDESVNRMDLVAMLEDNGYEVVGEAANGEEAIELTREKRPDVVCMDVKMPHMDGITAAGVICDENLAPVVMLTAFSQADLVKEAIGAGAMAYVTKPYEESKLLPALAVAMGRFAEINDLLDSVERNESELRTTQEQLRDAEEELRKTKETLEERKLIDRAKGLLMDKANFSESGAFRWIQKTSMDQRIPKKRLAQAIIEKYSDKPNDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUV3</accession>
    <name>B8DUV3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible solute binding protein of ABC transporter system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217744.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1500"/>
    <dbReference type="EnsemblBacteria" id="ACL29782">
        <property type="protein sequence ID" value="ACL29782"/>
        <property type="gene ID" value="BLA_1500"/>
    </dbReference>
    <dbReference type="GeneID" id="66533332"/>
    <dbReference type="KEGG" id="bla:BLA_1500"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1570"/>
    <dbReference type="HOGENOM" id="CLU_016838_0_1_11"/>
    <dbReference type="OMA" id="LNEHVWY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="334" mass="36419" checksum="E983AF066AF681FC" modified="2009-03-03" version="1">MRTLGNGLHAIAAILAGIALILGTSACSWFGSRQTNEPTPNGSTTPASKITVVATLNQWGSLAKQIGGNQVEVSSILPPDTTNAHSFEPNAKQVTQMRKAQVLLTNGAGYDTWADRSLPRNVTRVSVADTVGALDGDNPHLWFSRDARQAVARELTEVFSRLLPEHKAYFESNLKTWQSDEDELESQMRERSKSLKDPTYAATEDVAYYLMSDLGFRDVTPKGYAKAMLDGTEPDEKDIKAFSDLLQGRQTNLLINNPQQSAQTDATLTQAAHKASIPVIDITEQMPKDCKDLTSWIDTLSESIISKVSQEQEHEAASSPSPSVGTQQETPATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUY0</accession>
    <name>B8DUY0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Possible phospholipase/carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1527"/>
    <dbReference type="EnsemblBacteria" id="ACL29809">
        <property type="protein sequence ID" value="ACL29809"/>
        <property type="gene ID" value="BLA_1527"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1527"/>
    <dbReference type="HOGENOM" id="CLU_049413_5_0_11"/>
    <dbReference type="OMA" id="WGRDKAD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_2" evidence="2">
        <location>
            <begin position="57"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="270" mass="29442" checksum="36918C0AD576F158" modified="2009-03-03" version="1">MTEAANTTPSGPYAGQSAGERKRMEPPVGRVASVVPGHFGDRLTVTEALASRGGGNAQPNRPLFVCLHGWGSNEDDLAGIMRYVAPYSDFVSLRAPLVLQEASPRGFAMQQGAYSWFHDAVPVGDDLDYDAYAAACAIDDWVTTNVGENRDVVPIGFSQGGTLAVELLRVHPQRYRAAISLSGFVAPGNVPATTPYDDILADLNIPVFYGYGELDTVLPKYMIYETIAWLEEHTWLTARGYRGLDHAVSMEEFSDLRQWLLDQDIASGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV11</accession>
    <name>B8DV11_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA gyrase subunit A</fullName>
            <ecNumber evidence="8">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">gyrA</name>
        <name evidence="11" type="ordered locus">BLA_0006</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="8"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219027.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0006"/>
    <dbReference type="EnsemblBacteria" id="ACL28312">
        <property type="protein sequence ID" value="ACL28312"/>
        <property type="gene ID" value="BLA_0006"/>
    </dbReference>
    <dbReference type="GeneID" id="66532379"/>
    <dbReference type="KEGG" id="bla:BLA_0006"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.6"/>
    <dbReference type="HOGENOM" id="CLU_002977_6_1_11"/>
    <dbReference type="OMA" id="THHWLLF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01897">
        <property type="entry name" value="GyrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005743">
        <property type="entry name" value="GyrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="10">
        <location>
            <begin position="53"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="863"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GyrA-box" evidence="8">
        <location>
            <begin position="571"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL28312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="920" mass="102091" checksum="0AA8D8EC7DB05C91" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV27</accession>
    <name>B8DV27_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28328">
        <property type="protein sequence ID" value="ACL28328"/>
        <property type="gene ID" value="BLA_0023"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0023"/>
    <dbReference type="HOGENOM" id="CLU_1369868_0_0_11"/>
    <dbReference type="OMA" id="HACLYAV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="199" mass="21034" checksum="F2288ECE4DD0C9B1" modified="2009-03-03" version="1">MRQWRGIVSVIAAMAMIGGFAGCGQSQEQAGFSKSPQSSQTATGGASGEIGNMESEHHILPSSDVEELELRLESIGESTATGNLTLLGELHPTASYTERDGGRGMPSLQNQDELTFSDCKSYMLSVLCMGEGSVSIEWTLGTQSEQRNLECAPKIAETALGMSNVNAKSSTVKIVAEEGSKAEIAYRLDEIGKPGVVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV38</accession>
    <name>B8DV38_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219071.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28339">
        <property type="protein sequence ID" value="ACL28339"/>
        <property type="gene ID" value="BLA_0034"/>
    </dbReference>
    <dbReference type="GeneID" id="66532410"/>
    <dbReference type="KEGG" id="bla:BLA_0034"/>
    <dbReference type="HOGENOM" id="CLU_2803829_0_0_11"/>
    <dbReference type="OMA" id="ESGTLMC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="67" mass="7122" checksum="0DC9B6E176DD7D66" modified="2009-03-03" version="1">MRNLDEVIAAQGEDYAQFDQQAKQSVAACASLAMSIKSVLDTPILDESGALTDESGTLMRGFDGNPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV57</accession>
    <name>B8DV57_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-L-arabinosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">abfA</name>
        <name evidence="4" type="ordered locus">BLA_0055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219336.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0055"/>
    <dbReference type="CAZy" id="GH51">
        <property type="family name" value="Glycoside Hydrolase Family 51"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28358">
        <property type="protein sequence ID" value="ACL28358"/>
        <property type="gene ID" value="BLA_0055"/>
    </dbReference>
    <dbReference type="GeneID" id="66532431"/>
    <dbReference type="KEGG" id="bla:BLA_0055"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.60"/>
    <dbReference type="HOGENOM" id="CLU_017810_1_1_11"/>
    <dbReference type="OMA" id="SKYMRGW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-AF_C" evidence="3">
        <location>
            <begin position="302"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="513" mass="56867" checksum="ECA6626BF632521C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV58</accession>
    <name>B8DV58_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable sugar kinase</fullName>
            <ecNumber evidence="3">2.7.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.17" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219337.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0056"/>
    <dbReference type="EnsemblBacteria" id="ACL28359">
        <property type="protein sequence ID" value="ACL28359"/>
        <property type="gene ID" value="BLA_0056"/>
    </dbReference>
    <dbReference type="GeneID" id="66532432"/>
    <dbReference type="KEGG" id="bla:BLA_0056"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.61"/>
    <dbReference type="HOGENOM" id="CLU_509692_0_0_11"/>
    <dbReference type="OMA" id="ANFMRTH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07778">
        <property type="entry name" value="FGGY_L-RBK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042029">
        <property type="entry name" value="L-RBK-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="18"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="278"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="537" mass="58225" checksum="2A4F503EB902DE74" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV79</accession>
    <name>B8DV79_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable penicillin binding protein transpeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pbpA</name>
        <name evidence="2" type="ordered locus">BLA_0077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218373.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0077"/>
    <dbReference type="EnsemblBacteria" id="ACL28380">
        <property type="protein sequence ID" value="ACL28380"/>
        <property type="gene ID" value="BLA_0077"/>
    </dbReference>
    <dbReference type="GeneID" id="66532452"/>
    <dbReference type="KEGG" id="bla:BLA_0077"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.82"/>
    <dbReference type="HOGENOM" id="CLU_009289_1_0_11"/>
    <dbReference type="OMA" id="MWAPVTG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transpeptidase" evidence="1">
        <location>
            <begin position="157"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="488" mass="51509" checksum="7598CBB77C388953" modified="2009-03-03" version="1">MNKTLRQLFTAVIVLFVILGISSSIIMVNRANRLSHDSRNTRALYQTYGAPRGSILASDGTIIAKSDPVNDSFSYQRSYPQGDIYAPITGYFSIAQNADRGIEASENELLTGESNALFWQHVKALFTGKENKGASIETSIDPKLQTAAMEALKNNDGAAVAIEPKTGRILAMASTPSYDPNELASHDTGSVSKAYTELVTNPSNPMLNRAISELYPPGSTFKTVVAAAALDSGKYQLDTQIPAGASYTLPGTQTQLTNAEEPGNGTDGKISLKDAMAWSSNTAFAQLGVALGDESVSNMAKKFGFDKPIVIDGTDSNGLPMQAVASRFPTNVGDDRLALASIGQGDTVETPLQNAMIAAAIANDGKVMKPTLVDRVRFSDLSVMPDTKPQVMDTAFSADTANKLTEAMEAVVTDANPNLEIPGVKVAAKTGTAQIGANNSSIDGWVMGFAPADDPKIAVAVVVHNVDLYGSFAAGPIMTAIMKEALQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV84</accession>
    <name>B8DV84_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable dipeptidyl peptidase IV</fullName>
            <ecNumber evidence="3">3.4.14.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.14.5" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218379.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0082"/>
    <dbReference type="ESTHER" id="bifan-b2eam2">
        <property type="family name" value="DPP4N_Peptidase_S9"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.073"/>
    <dbReference type="EnsemblBacteria" id="ACL28385">
        <property type="protein sequence ID" value="ACL28385"/>
        <property type="gene ID" value="BLA_0082"/>
    </dbReference>
    <dbReference type="GeneID" id="66532457"/>
    <dbReference type="KEGG" id="bla:BLA_0082"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.87"/>
    <dbReference type="HOGENOM" id="CLU_006105_2_1_11"/>
    <dbReference type="OMA" id="VTHMTPQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPPIV_N" evidence="2">
        <location>
            <begin position="163"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="583"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="665"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="804" mass="87354" checksum="E85CB36831A025AC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV92</accession>
    <name>B8DV92_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable cation-transporting ATPase V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BLA_0090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218387.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0090"/>
    <dbReference type="EnsemblBacteria" id="ACL28393">
        <property type="protein sequence ID" value="ACL28393"/>
        <property type="gene ID" value="BLA_0090"/>
    </dbReference>
    <dbReference type="GeneID" id="66532466"/>
    <dbReference type="KEGG" id="bla:BLA_0090"/>
    <dbReference type="HOGENOM" id="CLU_001771_6_3_11"/>
    <dbReference type="OMA" id="AQVVIMN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="685"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="713"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL28393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="744" mass="79606" checksum="7CF5F1295F3D8651" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-12-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVA4</accession>
    <name>B8DVA4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative DNA-damage-inducible protein J</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RelB/DinJ antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28405">
        <property type="protein sequence ID" value="ACL28405"/>
        <property type="gene ID" value="BLA_0102"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0102"/>
    <dbReference type="HOGENOM" id="CLU_154558_5_2_11"/>
    <dbReference type="OMA" id="NMTTAIN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007337">
        <property type="entry name" value="RelB/DinJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38781">
        <property type="entry name" value="PTHR38781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04221">
        <property type="entry name" value="RelB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02384">
        <property type="entry name" value="RelB_DinJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="86" mass="9762" checksum="9063FF1F7F942510" modified="2009-03-03" version="1">MSETATVSFRTDPKVKEEAKALYESMGMDLSTALNVFLRQSIRDNGMPFKITREQPESIEARRQTEAHEGRSFTSSESLMKDLMDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVB5</accession>
    <name>B8DVB5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0113"/>
    <dbReference type="EnsemblBacteria" id="ACL28416">
        <property type="protein sequence ID" value="ACL28416"/>
        <property type="gene ID" value="BLA_0113"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0113"/>
    <dbReference type="HOGENOM" id="CLU_060077_8_0_11"/>
    <dbReference type="OMA" id="MPHIDRS"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="136" mass="15711" checksum="93A3A034F2079C6A" modified="2009-03-03" version="1">MGATMYTMKQACELTGLSYETLKFYCRSELVPRVHRDARNHRVFDDHNIAWIRSLVCLRRCGLGIAEMKRCVALCLEGEASIPQRREILAEKREELQHRLQDIEDSIAYIDAKEQFYEAVLDGTTPYVSNVLGLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVD3</accession>
    <name>B8DVD3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Branched-chain amino acid transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">livF</name>
        <name evidence="4" type="ordered locus">BLA_0131</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218431.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0131"/>
    <dbReference type="EnsemblBacteria" id="ACL28434">
        <property type="protein sequence ID" value="ACL28434"/>
        <property type="gene ID" value="BLA_0131"/>
    </dbReference>
    <dbReference type="GeneID" id="66532506"/>
    <dbReference type="KEGG" id="bla:BLA_0131"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.137"/>
    <dbReference type="HOGENOM" id="CLU_1164080_0_0_11"/>
    <dbReference type="OMA" id="MIAMNNA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870519" evidence="2">
        <location>
            <begin position="38"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="3">
        <location>
            <begin position="45"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="239" mass="24610" checksum="2915EEE963545F6F" modified="2009-03-03" version="1">MNNAKIKSWMVTATAMAAAAMLTLSGCGSGAESKADADEATFTAAGLLPLTGSMAYLGPANIATMKLAQNDINAAGGVLGKDIDIVSADTSDADHADQNTSSAQSVLAREPSVVVGPPSSSVVKNTFKQVTSSQVPMISSGATSTAFSGLNDYFFRTIPPDTVQGVVLGQIIVQDGVKNLAIAVFNDEYGTSLRDVVAKTVGDAGVNVVYGEKETFDPTETSFSSMVTNIKSTKPDALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVD9</accession>
    <name>B8DVD9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane transport protein possibly for shikimate</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">shiA</name>
        <name evidence="7" type="ordered locus">BLA_0137</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218444.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0137"/>
    <dbReference type="EnsemblBacteria" id="ACL28440">
        <property type="protein sequence ID" value="ACL28440"/>
        <property type="gene ID" value="BLA_0137"/>
    </dbReference>
    <dbReference type="GeneID" id="66532512"/>
    <dbReference type="KEGG" id="bla:BLA_0137"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.145"/>
    <dbReference type="HOGENOM" id="CLU_001265_39_5_11"/>
    <dbReference type="OMA" id="SWVGGYV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="36"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL28440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="463" mass="49484" checksum="86110603BBCFF4E3" modified="2009-03-03" version="1">MTAVETETEAGRRAPALAGERAHALRRAGKSSVGTIIAASMVGTTIEFYDFYAYGTAAANYFPRVFFSDATNPTVALLLSLVTFAVAFLARPVGSLIFGHFGDSIGRKATLVVSLMTMGVATFLIGCLPGYDMWGVWAVLALCVCRFVQGIGLGGEWSGAALVATENAPANKRALYGSFPELGAPIGFFLCNGTYVLLELFNDDAAMLAWGWRVPFLLSSLLVVVGLLVRVHMEETPAFRAAKQDQRVVKAPALEVFRTSWRQVLQATFLVAVTYTLFYTLATWSLAWATKSDAQGGGGLGFSTKEYMTMLMVSVCVFALFIVLSCVFADRIGRRRVIIGSSVALLAFAALFPLLMNRAVVGVHNTAAAMLFLCLGFALMGIAFGPIGALLPELFSVNVRYTGSGIGYNIAAIVGAAFVPSVATWLSSHWGVGSVGLYLGVMALCCLVAILTCRETKNVDYMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVF3</accession>
    <name>B8DVF3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP binding protein of ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_0151</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218459.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28454">
        <property type="protein sequence ID" value="ACL28454"/>
        <property type="gene ID" value="BLA_0151"/>
    </dbReference>
    <dbReference type="GeneID" id="66532525"/>
    <dbReference type="KEGG" id="bla:BLA_0151"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.159"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OMA" id="WKEYGDQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="233" mass="25323" checksum="F87B6CE4A618D57E" modified="2009-03-03" version="1">MAYIEFNDVVKEYPAGSSSIRALDGASFAADEGELSVILGQSGAGKTTALNILGGMDTATSGRVIVGGRDITDLNHHDLVTYRRNDIGFVFQFYNLIPNLTALENVELASQICTDHFDPAQTLAKVGLADRLGNFPAQLSGGEQQRVSIARALAKKPKLLLCDEPTGALDYETGKEVLQLLQDICRTERMTVLIVTHNSALAPMAHKVIRFRSGKVTSQETNEHPVPISQIEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVG0</accession>
    <name>B8DVG0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative secreted polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_0159</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218472.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0159"/>
    <dbReference type="EnsemblBacteria" id="ACL28461">
        <property type="protein sequence ID" value="ACL28461"/>
        <property type="gene ID" value="BLA_0159"/>
    </dbReference>
    <dbReference type="GeneID" id="66532535"/>
    <dbReference type="KEGG" id="bla:BLA_0159"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.169"/>
    <dbReference type="HOGENOM" id="CLU_540446_0_0_11"/>
    <dbReference type="OMA" id="KSECGTR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="4">
        <location>
            <begin position="293"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="227"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="508" mass="53690" checksum="EB28FE99D58AF170" modified="2009-03-03" version="1">MGGKSSGQGNDTPHDAAQHGTTQHSTAHADDFDTMHAEFADTATGSAADSAAYEPTAPRKRRNAVIAIAVTALIIVGVLAAIIIPISRANHRHAEEEHSAALADCESAQREFATLNTTYTVTLANAGKLAKGDGKTISEDHATALASKIEHIDDTHTVSSLVKSECDTRQSTDDLNELTRRFGAASTSMVNRMRDVQTDADTLRRLVEGARNSNRRGELQKQLTIAKAAYERSANKAAENLRAALQAQIANAGALLEPGSTATNPQVNDALGSLTDATNAVINAMPLDCEFAACVALTFDDGPNKQITPQLLAALKQADAPATFFVQGQFVSGSNTQLLANMAAQGNEIGSMSWRHKQLHTLSPAELTKWFNDTDDVIESAGAGKPTLFRPPDGAWSEDVVDAAKRSGQSVILWNVDSRDWDAQASAADIAKTVLDGASSGAIIALHDGNERTVEAIPQIVSGLRERGFTPVTVSTLLDGELEPGTVFYARGDTAQDSAPSDGVEVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVI4</accession>
    <name>B8DVI4_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT</fullName>
            <ecNumber evidence="1">6.3.5.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murT</name>
        <name evidence="4" type="ordered locus">BLA_0183</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57928"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:59488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:143132"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+) = beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:143132"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with GatD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurCDEF family. MurT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.13" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0183"/>
    <dbReference type="EnsemblBacteria" id="ACL28485">
        <property type="protein sequence ID" value="ACL28485"/>
        <property type="gene ID" value="BLA_0183"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0183"/>
    <dbReference type="HOGENOM" id="CLU_041534_0_0_11"/>
    <dbReference type="OMA" id="WLWDVDY"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140282">
        <property type="term" value="F:carbon-nitrogen ligase activity on lipid II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02214">
        <property type="entry name" value="Lipid_II_synth_MurT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043703">
        <property type="entry name" value="Lipid_II_synth_MurT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013564">
        <property type="entry name" value="MurT_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08353">
        <property type="entry name" value="MurT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="2">
        <location>
            <begin position="60"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="MurT_C" evidence="3">
        <location>
            <begin position="366"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="491" mass="53221" checksum="AC77101E051A2DFA" modified="2009-03-03" version="1">MRTHAPWYGFATPFVGKSVRWASRLLHHGGSAFPGKVVERFDPTFLSRTLSTLPLGVVLVSGTNGKTTTTRMVATMLESLGLKVFTNPTGSNFTRGVVSSILTEVPLNGRLDADIAVLELDEAYAVHFVEQVQPRYALLLNVMRDQLDRFGEIDNTARLLGHVAAATRGTVVLNREDPRIARLRDVVKDGVRTRYFGLAEGLRHYFPADDDMTTTFQVQSADSAQAPEAADAQIVDVAHDVGTAHELHADVMLTKVGDHHAQMVIDGREYESDVKLEGVYNLFNAAAALAVVRAVQADLRKPNAVGYAAAQLGRADSARARAFTARAHTFADADTDALFAALADVTPAFGRGEVIDVNGSPVELLLVKNPMGFRLALASFPPESADTMIAINDQYADGRDMSWLWDVDFTSLRPTGVAMVSGVRAWDMALRLEYDQVPVARVEPDLNAAVREFVNANPGTPKHIYCTYTAMLAIRAELATVADVADAGVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVM8</accession>
    <name>B8DVM8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619673.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0227"/>
    <dbReference type="EnsemblBacteria" id="ACL28529">
        <property type="protein sequence ID" value="ACL28529"/>
        <property type="gene ID" value="BLA_0227"/>
    </dbReference>
    <dbReference type="GeneID" id="66532603"/>
    <dbReference type="KEGG" id="bla:BLA_0227"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.239"/>
    <dbReference type="HOGENOM" id="CLU_629569_0_0_11"/>
    <dbReference type="OMA" id="TCGFGSY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="31"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="425" mass="46807" checksum="40CDBA92C0C1C7F8" modified="2009-03-03" version="1">MSEQSAEMSEAKPVSVSRRLGRLQFHKSGKFRVLQLADVQDGPKISKDTIALITAAIRDARPDLVVFSGNQIAGYDPAFAATFTKRRWKTAVGAAPKSADLAHTRELVRGQIEQMVQPMVDAGVPWAVTYGNHDFQCGLTNAELDGIFREFPLCVNPSTRAKFGAETWSRALPKERVIASGEPGTFSMPVCDESGNTVFGIVLVDSGDYSETGGYGAPSQTALRFLRTVPQWFGEGVESIVFQHMPLPQYYRVLKPVPRTTDRSVEGYRNYSGSYFVLDDAKTERGGYLGEGVSCPDLDSGEFDILRDSHAYFAVAAGHDHRNAFAGEYAGVQMIATPTCGFDSYGPIPERRAARLFEFDERHPFSPRTQLLQFGELVGKPSSKKAYVYGMSSASKPKSEGVNLLHKPSTVSRLWHSVGNWLFNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVP5</accession>
    <name>B8DVP5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0244"/>
    <dbReference type="EnsemblBacteria" id="ACL28546">
        <property type="protein sequence ID" value="ACL28546"/>
        <property type="gene ID" value="BLA_0244"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0244"/>
    <dbReference type="HOGENOM" id="CLU_019396_0_0_11"/>
    <dbReference type="OMA" id="CARWDAY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="912" mass="98336" checksum="3F6D22E58741E3F7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVR0</accession>
    <name>B8DVR0_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">ffh</name>
        <name evidence="10" type="ordered locus">BLA_0259</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0259"/>
    <dbReference type="EnsemblBacteria" id="ACL28561">
        <property type="protein sequence ID" value="ACL28561"/>
        <property type="gene ID" value="BLA_0259"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0259"/>
    <dbReference type="HOGENOM" id="CLU_009301_6_0_11"/>
    <dbReference type="OMA" id="DTAGRHK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00959">
        <property type="entry name" value="ffh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54" evidence="9">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="505"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="527"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="153"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="251"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="309"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL28561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="590" mass="62745" checksum="3FF7C68C9DED7BA7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVS2</accession>
    <name>B8DVS2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Possible reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268389.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0271"/>
    <dbReference type="EnsemblBacteria" id="ACL28573">
        <property type="protein sequence ID" value="ACL28573"/>
        <property type="gene ID" value="BLA_0271"/>
    </dbReference>
    <dbReference type="GeneID" id="66532646"/>
    <dbReference type="KEGG" id="bla:BLA_0271"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_11"/>
    <dbReference type="OMA" id="YSMINRW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="PTHR43150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="32"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="335" mass="37454" checksum="8436DE69A7CA8E90" modified="2009-03-03" version="1">MPDFITHYSPAPDRYDRMQYAHVGTSGLQLPRIALGLWHNFGDLTPYGQMQQIVFTAFDHGIFHFDLANNYGPMYGAAERNFGHIMRESLRPYRDELIISTKAGFDMWAGPNGVGGSRKYLLSSLDQSLERLGLDYVDIFYHHCPDPNTPLEETVGALETAVTSGRALYVGLSNYDGPLLEQAAQMLAERHVPFIINQNRYNIFDRTIERNGLKEATSKLGKGLITFSPLEQGLLTNRYLNGIPADSRIGHDDRFLNKSALTESRLTQIRELNDLALSRGQTLAEMSLAWLLNDPAVTTVLVGASKPQQILDDIAALNNTHFTPEELARIDSISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVT0</accession>
    <name>B8DVT0_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-6-phosphate isomerase</fullName>
            <shortName evidence="7">GPI</shortName>
            <ecNumber evidence="7">5.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphoglucose isomerase</fullName>
            <shortName evidence="7">PGI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphohexose isomerase</fullName>
            <shortName evidence="7">PHI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">pgi</name>
        <name evidence="9" type="ordered locus">BLA_0279</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268405.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0279"/>
    <dbReference type="EnsemblBacteria" id="ACL28581">
        <property type="protein sequence ID" value="ACL28581"/>
        <property type="gene ID" value="BLA_0279"/>
    </dbReference>
    <dbReference type="GeneID" id="66532656"/>
    <dbReference type="KEGG" id="bla:BLA_0279"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.296"/>
    <dbReference type="HOGENOM" id="CLU_017947_3_1_11"/>
    <dbReference type="OMA" id="IGVWYIN"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4 7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL28581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="565" mass="63025" checksum="DC9FE1EB448F7703" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVU5</accession>
    <name>B8DVU5_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Transcription termination/antitermination protein NusG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">nusG</name>
        <name evidence="10" type="ordered locus">BLA_0294</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Participates in transcription elongation, termination and antitermination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the NusG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268433.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0294"/>
    <dbReference type="EnsemblBacteria" id="ACL28596">
        <property type="protein sequence ID" value="ACL28596"/>
        <property type="gene ID" value="BLA_0294"/>
    </dbReference>
    <dbReference type="GeneID" id="66532672"/>
    <dbReference type="KEGG" id="bla:BLA_0294"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.314"/>
    <dbReference type="HOGENOM" id="CLU_067287_0_1_11"/>
    <dbReference type="OMA" id="DGPFNGF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00948">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001062">
        <property type="entry name" value="Transcrpt_antiterm_NusG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015869">
        <property type="entry name" value="Transcrpt_antiterm_NusG_bac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265:SF2">
        <property type="entry name" value="PTHR30265:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00338">
        <property type="entry name" value="NUSGTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00922">
        <property type="entry name" value="nusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01014">
        <property type="entry name" value="NUSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="3 5 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 5 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NGN" evidence="8">
        <location>
            <begin position="142"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="9">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="38"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL28596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="330" mass="35644" checksum="48010E010468C483" modified="2009-03-03" version="1">MTDEVNLENIDDLPINLDAVSADDNTADAQEVQIDQVEAASESEDIAEGMAYDAVSAGDDAQPSDQAAAQEDSLTDSVDDSAAVDSDAHSEGTADEDTQHADAEEAAADEAPEAAAEAEEEAEEDAGSKAVKEFSKSLRTLEGKWYVLHTYSGYEKRVKSNIESRVQSFGLEDTIFQVEVPMEEVEKHTEKGKKVVTRVRVPGYVLIRMYPDENARRIVRETEGVTGFVGPSREPAPLSRKEVVSMMAPMIASHALKEAGDKPAAAKKRTLEVSYKVGDQVTVTDGPFTSMSAVVSDVEPATQKLTVLVSIFGRDTPVELGFDQVQRLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW21</accession>
    <name>B8DW21_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpmC</name>
        <name evidence="6" type="ordered locus">BLA_0370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268587.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0370"/>
    <dbReference type="EnsemblBacteria" id="ACL28672">
        <property type="protein sequence ID" value="ACL28672"/>
        <property type="gene ID" value="BLA_0370"/>
    </dbReference>
    <dbReference type="GeneID" id="66532753"/>
    <dbReference type="KEGG" id="bla:BLA_0370"/>
    <dbReference type="HOGENOM" id="CLU_158491_3_3_11"/>
    <dbReference type="OMA" id="EHELGIM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_L29_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL28672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="82" mass="9325" checksum="D29BA7EF459372BA" modified="2009-03-03" version="1">MPVGSEEYTIKNLNEKTNAEIEGFIKKSKEELFNLRFQHATGQLENTARLKAVKRDIARMYTVLRERELGISQAPAATETKA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW23</accession>
    <name>RL14_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplN</name>
        <name type="ordered locus">BLA_0372</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268590.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DW23"/>
    <dbReference type="SMR" id="B8DW23"/>
    <dbReference type="STRING" id="442563.BLA_0372"/>
    <dbReference type="EnsemblBacteria" id="ACL28674">
        <property type="protein sequence ID" value="ACL28674"/>
        <property type="gene ID" value="BLA_0372"/>
    </dbReference>
    <dbReference type="GeneID" id="66532755"/>
    <dbReference type="KEGG" id="bla:BLA_0372"/>
    <dbReference type="HOGENOM" id="CLU_095071_2_1_11"/>
    <dbReference type="OMA" id="AKEVLCI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_L14P_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000166899" description="50S ribosomal protein L14">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <sequence length="122" mass="13253" checksum="23D416327F4AC9F5" modified="2009-03-03" version="1">MIQQETRLHVADNTGAKELLAIRVLGGSKRRYAGIGDVIVASVKDAIPGGSVKKGDVVKAVVVRTVKERRRADGSYIKFDENAAVILGSGREPKGTRIFGPVGRELRDKRFMRIVSLAPEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW65</accession>
    <name>B8DW65_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="6">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">lysS</name>
        <name evidence="9" type="ordered locus">BLA_0414</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6 7">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="6"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619713.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0414"/>
    <dbReference type="EnsemblBacteria" id="ACL28716">
        <property type="protein sequence ID" value="ACL28716"/>
        <property type="gene ID" value="BLA_0414"/>
    </dbReference>
    <dbReference type="GeneID" id="66532799"/>
    <dbReference type="KEGG" id="bla:BLA_0414"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.442"/>
    <dbReference type="HOGENOM" id="CLU_008255_6_0_11"/>
    <dbReference type="OMA" id="EIFGEKC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="236"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL28716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="554" mass="61419" checksum="10DD5493037C8BEC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW71</accession>
    <name>B8DW71_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carboxypeptidase C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0420"/>
    <dbReference type="EnsemblBacteria" id="ACL28722">
        <property type="protein sequence ID" value="ACL28722"/>
        <property type="gene ID" value="BLA_0420"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0420"/>
    <dbReference type="HOGENOM" id="CLU_032786_0_0_11"/>
    <dbReference type="OMA" id="TATAWYH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="PTHR11802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="513" mass="57001" checksum="74BFC00E2407CEC2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW75</accession>
    <name>B8DW75_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Myosin-crossreactive antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268697.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0424"/>
    <dbReference type="EnsemblBacteria" id="ACL28726">
        <property type="protein sequence ID" value="ACL28726"/>
        <property type="gene ID" value="BLA_0424"/>
    </dbReference>
    <dbReference type="GeneID" id="66532808"/>
    <dbReference type="KEGG" id="bla:BLA_0424"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.452"/>
    <dbReference type="HOGENOM" id="CLU_024043_2_0_11"/>
    <dbReference type="OMA" id="CRLIHKR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050151">
        <property type="term" value="F:oleate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010354">
        <property type="entry name" value="Oleate_hydratase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37417">
        <property type="entry name" value="PTHR37417"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06100">
        <property type="entry name" value="MCRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="708" mass="79954" checksum="77F3EAEB81926F7B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW77</accession>
    <name>B8DW77_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sensor protein</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268708.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0427"/>
    <dbReference type="EnsemblBacteria" id="ACL28728">
        <property type="protein sequence ID" value="ACL28728"/>
        <property type="gene ID" value="BLA_0427"/>
    </dbReference>
    <dbReference type="GeneID" id="66532812"/>
    <dbReference type="KEGG" id="bla:BLA_0427"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.456"/>
    <dbReference type="HOGENOM" id="CLU_000445_89_2_11"/>
    <dbReference type="OMA" id="SEHARME"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="206"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="462" mass="50640" checksum="D303D94BFFEC9265" modified="2009-03-03" version="1">MPQFTTTVIAVAFILLAVGAVIGLLVLLYDWLAPLISRTTHGVSLPDSIGDLVSRLRRRRSRDDEDGDDDDDDELDDEAAALLSILPAASIVVDDSDDVVRANPAAYRLGIVNDDVIVDSRVLDAVRKVREHGGKTSLEITTSTPKRFALPEPVDTEEDLKTSTVSRPNWLKLVIGRIDEQFVVVLIDDISESVRFSQMRDDFVTNVSEMIIRPSEDLQRLADVLEHGGMSPEQVAQAARDVRRSSAYVDHMVKNLLLLIKAQGDAPNAQSAVLDVREQVEVAVNELLPQARQRGITVSITGKGEPKVRGNATAIRAAIGKLVDNAIEYSPDNANVSVLIETTRDTKDALVRVVDRGTGIPLKEQPRIFERFYRGANQNERTQSGVGLGLAIVKHVAIMHHGNVQVWSRPGQGSTFSLVLPLVPESAEEAGEISRRRADGNRDGENAPTQAMRNQSTRHTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWA6</accession>
    <name>B8DWA6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidyl-prolyl cis-trans isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268772.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0458"/>
    <dbReference type="EnsemblBacteria" id="ACL28757">
        <property type="protein sequence ID" value="ACL28757"/>
        <property type="gene ID" value="BLA_0458"/>
    </dbReference>
    <dbReference type="GeneID" id="66532841"/>
    <dbReference type="KEGG" id="bla:BLA_0458"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.487"/>
    <dbReference type="HOGENOM" id="CLU_100497_0_0_11"/>
    <dbReference type="OMA" id="AIGWSKS"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025241">
        <property type="entry name" value="DUF4190"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13828">
        <property type="entry name" value="DUF4190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4190" evidence="2">
        <location>
            <begin position="87"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="196" mass="21318" checksum="28B6467A63A9CAEB" modified="2009-03-03" version="1">MRLCRAFLQYALHMTANDTLGSPYSSPDPNEHGDNPYVGDPGYSQVPQQAYTAQYATPQPNYTQQYPPQGAYGYPMAPVDQWNGMCIAGFICSFFFPLVGLVLSIIALVQINKTGEKSRGMAIAGIVIGGISTALALIAIIMVICGLAIGLGALAETGWDDYEYHYDTHSDYSQFDEVGADYLAHIRSVDQLMKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWA7</accession>
    <name>B8DWA7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0459</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268776.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0459"/>
    <dbReference type="EnsemblBacteria" id="ACL28758">
        <property type="protein sequence ID" value="ACL28758"/>
        <property type="gene ID" value="BLA_0459"/>
    </dbReference>
    <dbReference type="GeneID" id="66532842"/>
    <dbReference type="KEGG" id="bla:BLA_0459"/>
    <dbReference type="HOGENOM" id="CLU_1599510_0_0_11"/>
    <dbReference type="OMA" id="YMPPAAN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025241">
        <property type="entry name" value="DUF4190"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13828">
        <property type="entry name" value="DUF4190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4190" evidence="3">
        <location>
            <begin position="104"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="166" mass="18288" checksum="74B1B49268DDC38F" modified="2009-03-03" version="1">MTNYQPNYDSNNPYGRGLSEPPMQQEPNQTPFAQPQYGDYGAQGNAQQPYAQPQYGQYARGSGQQYGQPDYTQNMSNYAPYGQCNQSQYGNGYSPEPTTWNGLCIAGFVCSFLVPIVGLILSIIALTQINRTGEKSRGMAIAGIVISVVIWLFSFIFMASGNSIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWE6</accession>
    <name>B8DWE6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28797">
        <property type="protein sequence ID" value="ACL28797"/>
        <property type="gene ID" value="BLA_0498"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0498"/>
    <dbReference type="HOGENOM" id="CLU_3022781_0_0_11"/>
    <dbReference type="OMA" id="ANTWENM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="55" mass="6079" checksum="B47089D39093576D" modified="2009-03-03" version="1">MVSETDKPQADPATGEPEVDAEGCATAHKHKVAEQNEKDLLFESADTWQHMEVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWK4</accession>
    <name>B8DWK4_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glucose--hexose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">UDP-glucose--hexose-1-phosphate uridylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">galT</name>
        <name evidence="17" type="ordered locus">BLA_0556</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="5"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0556"/>
    <dbReference type="EnsemblBacteria" id="ACL28855">
        <property type="protein sequence ID" value="ACL28855"/>
        <property type="gene ID" value="BLA_0556"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0556"/>
    <dbReference type="HOGENOM" id="CLU_029960_1_1_11"/>
    <dbReference type="OMA" id="HAIYYPP"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="PTHR11943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GalP_UDP_transf" evidence="15">
        <location>
            <begin position="78"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="GalP_UDP_tr_C" evidence="16">
        <location>
            <begin position="254"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="13">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ACL28855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="423" mass="47838" checksum="0FBE6FE3AA2FC6B9" modified="2009-03-03" version="1">MSQTPNQPEFAHYQPGEYAAEHLRITPTTLSDGRDFFYLDDEPEYVNGSRTRVLDDPRDLDYRFAPHLNAEGVEVKYAAPQMRRDPLTGDWIPMATARMNRPITAGAGATAKGNPLAARKPGDPYQDGEVPDTDYDVVVFENRFPSMVQVPGVPNEVRYVDGNPLWQERPAAGRCEVICFDSDENGLPADLPVERLRTVVEAWAFRTAELSAIDGIEQVFPFENHGEEIGVSLAHPHGQIYAYPFIAPKLETELQHTQAYFERTGGNLLRDLMHAEIDAGERVIMRNHSWVAYVPAAARWPLEVHVQPLRDGILTLDQLNDAERWDLAQMYSTLLRRGNRFFDKGDGKGMDLPYIAAWHQAPVRDARRENYRLNLQFFSFRRAANKIKYLAGSESGMAAWVSDTTPELIAQRFHELGPVDIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWK7</accession>
    <name>B8DWK7_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dihydroorotate oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BLA_0559</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0559"/>
    <dbReference type="EnsemblBacteria" id="ACL28858">
        <property type="protein sequence ID" value="ACL28858"/>
        <property type="gene ID" value="BLA_0559"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0559"/>
    <dbReference type="HOGENOM" id="CLU_013640_2_0_11"/>
    <dbReference type="OMA" id="ERIKMGA"/>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="8">
        <location>
            <begin position="29"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL28858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="338" mass="37104" checksum="8699052A5F56C28E" modified="2009-03-03" version="1">MIRFCQITGKMPPLMWLCRTMLNYTDPILETNVMGINFANPFGLSAGLDKNCDMAAVLDHAGFGFETVGSTTSRPCAGNPRPWFHRLPEYDSMMVHVGLANDGSDVVIERAEDAWRRTQSMQLSVSIARTNDDQVGDLNEGIEDYCISMERAAGRTAMVEVNVSCPNTTVGEPFTESAENLDKLFAALDRIERPQPTLVKMPLNKPWPQFKEFLDVLAAHNVQGVTIANLQKDRTGLDDIPKDWLGGLSGGPCTVASTELIRRTYAEYGDRFAIAGVGGVFTPEQAYEKIRAGSSLIMFISSLMYRGPQQITVLKRGLAKLLRRDGFGSVAEAVGVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWM1</accession>
    <name>B8DWM1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0575"/>
    <dbReference type="EnsemblBacteria" id="ACL28872">
        <property type="protein sequence ID" value="ACL28872"/>
        <property type="gene ID" value="BLA_0575"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0575"/>
    <dbReference type="HOGENOM" id="CLU_059319_0_0_11"/>
    <dbReference type="OMA" id="WSPTATN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007137">
        <property type="entry name" value="DUF348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011098">
        <property type="entry name" value="G5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03990">
        <property type="entry name" value="DUF348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07501">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01208">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51109">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="G5" evidence="3">
        <location>
            <begin position="102"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="319" mass="34097" checksum="48231C0216056483" modified="2009-03-03" version="1">MAGVVATQSMYSRAEAQPTPSATAYSITESNHAASRGNAREAMDGDTSYVTVKVNGKSRVVLGQDFTDVKSVLDAGDITLEPGDQVNPSLTTKVDESTTISIERQGAKMETTESKIPFNTVKKDDPSLPKGTEKVQTEGEEGILEKTNLVTRTGDKVVSSNTFATWVKKAPVEKVVLVGTGNPQPAATSAPAQTSNNSNTNANNSSQQAAASSIGSTAPVGEMQQWAHDYLLANGGSEGDFTATVYIISRESGWNVNATNPSSGAYGLAQALPGSKMASHGADWQSNYQTQLKWFWDYCKGRYGSVQGAYNFWQANHWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWN3</accession>
    <name>B8DWN3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218319.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0587"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28884">
        <property type="protein sequence ID" value="ACL28884"/>
        <property type="gene ID" value="BLA_0587"/>
    </dbReference>
    <dbReference type="GeneID" id="66533715"/>
    <dbReference type="KEGG" id="bla:BLA_0587"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.618"/>
    <dbReference type="HOGENOM" id="CLU_025996_25_0_11"/>
    <dbReference type="OMA" id="RTYCAII"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="337" mass="38127" checksum="78EC937F21F037B0" modified="2009-03-03" version="1">MPEISVIIPVYNQEEYVGACMDSLLDQSFEDFEVLAVNDGSTDASVSILEGYEQRDGRVQLIDQNNSGVSVARNNGLSHAKGEWVCFIDPDDYVAPDYLDTLLKATERNTDIAMSTCVAFDDQRSARQHFFPESFTARAADEKVELFRQLMDGSYAQPKGFVTAIGVPWGKLYRHAFLQEHGLQFDAALPRMQDNLFNMQAFQLAHEIVYVDYAGYYYRMGGLSARTYKNNARGLYHPAIDERARLMREYHLDGDATLLRAWNEEQVNLYFQELKAVIMLADPQSVKQAARTRAQALGPRLDQIDVSALSPAIRFKYTMMRNATLCSLLVRALRAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWP7</accession>
    <name>B8DWP7_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pyridoxal 5'-phosphate synthase subunit PdxT</fullName>
            <ecNumber evidence="4">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Pdx2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Pyridoxal 5'-phosphate synthase glutaminase subunit</fullName>
            <ecNumber evidence="4">3.5.1.2</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">pdxT</name>
        <name evidence="7" type="ordered locus">BLA_0601</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="4"/>
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        <property type="nucleotide sequence ID" value="NC_011835.1"/>
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        <property type="protein sequence ID" value="ACL28898"/>
        <property type="gene ID" value="BLA_0601"/>
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        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
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        <property type="entry name" value="PdxT/SNO_CS"/>
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        <property type="entry name" value="PLP_synth_Pdx2"/>
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        <property type="entry name" value="PDXT_SNO_1"/>
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        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0315">Glutamine amidotransferase</keyword>
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    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="L-glutamine binding" evidence="4 6">
        <location>
            <begin position="68"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="4 6">
        <location>
            <begin position="164"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4 5">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4 5">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL28898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="216" mass="23317" checksum="D962E6BC7C83C995" modified="2009-03-03" version="1">MVVDVSYISKEHSEDATTASSGVTGILAVQGAFAEHAAMLDRLGAPWKLLRAREDFDESIDRVILPGGESTTQGKLLRSTGLFEPINEHIKAGKPVFGTCAGMILLAQRLENDPNVYFGALDATVRRNAYGRQLGSFMATENVATFHADGTPAGVIENFPLVFIRGPFVAETGANARVMCEANGNTVALQQGRILATAFHPEITPDTRIHEFFLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWQ1</accession>
    <name>B8DWQ1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP binding protein of ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BLA_0605</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_011835.1"/>
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    <dbReference type="KEGG" id="bla:BLA_0605"/>
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    </dbReference>
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        <property type="entry name" value="ABC1_TM_sf"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
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    </feature>
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    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="668"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="705"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="777"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="809"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="895"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="928"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="21"/>
            <end position="323"/>
        </location>
    </feature>
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        <location>
            <begin position="354"/>
            <end position="594"/>
        </location>
    </feature>
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        <location>
            <begin position="670"/>
            <end position="938"/>
        </location>
    </feature>
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        <location>
            <begin position="984"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="391"/>
            <end position="398"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="1017"/>
            <end position="1024"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL28902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="1193" mass="128724" checksum="579B1C366FC5EBD1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWV5</accession>
    <name>B8DWV5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tubuliform spidroin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0663"/>
    <dbReference type="EnsemblBacteria" id="ACL28956">
        <property type="protein sequence ID" value="ACL28956"/>
        <property type="gene ID" value="BLA_0663"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0663"/>
    <dbReference type="HOGENOM" id="CLU_027190_0_0_11"/>
    <dbReference type="OMA" id="VGSYTTH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867675" evidence="2">
        <location>
            <begin position="42"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="671" mass="69610" checksum="74D32EC68F0ED4E4" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSJ7</accession>
    <name>B8DSJ7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamyl-Q tRNA(Asp) synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gluQ</name>
        <name evidence="7" type="ordered locus">BLA_0683</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219101.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0683"/>
    <dbReference type="EnsemblBacteria" id="ACL28976">
        <property type="protein sequence ID" value="ACL28976"/>
        <property type="gene ID" value="BLA_0683"/>
    </dbReference>
    <dbReference type="GeneID" id="66533816"/>
    <dbReference type="KEGG" id="bla:BLA_0683"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.712"/>
    <dbReference type="HOGENOM" id="CLU_015768_0_0_11"/>
    <dbReference type="OMA" id="WLLRMED"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="6">
        <location>
            <begin position="4"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL28976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="338" mass="37708" checksum="7A34B8864CDC5A8A" modified="2009-03-03" version="1">MAGRFAPTPSGRMHLGNAFAMLAAWLSARSRHEPIYLRIEDIDTPRVLPGADRMIMDDLTWLGLDWDGEPVYQSARQAVYDAVFERLRSLDGDALLYPCFCSRAEIRAASAPQEGDGFLVYPGTCRRLRDEDRDEVERRLAAGRRHSWRLAVPGAQEPGAFVAFDDLVYGAQSFNVGRELGDVILRRSDGLYAYQFVVTVDDLLMGVSDVVRGRDLLRSTALQIWLRGQMLRTGLGSHNLPAADPQYAHVPLLDNAAGVRLAKRERSLDLGRLREAGVRPDQVIGYCAWHMGLCEGVLERPEAMSAQQALNLFSWRKVRRHAGDVVVPGNIVEVLRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSL4</accession>
    <name>B8DSL4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD+ synthetase</fullName>
            <ecNumber evidence="2">6.3.5.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.5.1" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219452.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0700"/>
    <dbReference type="EnsemblBacteria" id="ACL28993">
        <property type="protein sequence ID" value="ACL28993"/>
        <property type="gene ID" value="BLA_0700"/>
    </dbReference>
    <dbReference type="GeneID" id="66533903"/>
    <dbReference type="KEGG" id="bla:BLA_0700"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.730"/>
    <dbReference type="HOGENOM" id="CLU_1507796_0_0_11"/>
    <dbReference type="OMA" id="EGIRMIM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="178" mass="19037" checksum="F9D8BE70CCDAFDD3" modified="2009-03-03" version="1">MIMNNGFVPVATASPNTRVADPMANAELCCDAIVRAANAGAKVVALPEVVLTSYIADDMLCHDIVLGAAEETLAHLVAETAKLDVVFSVGLPLCVNGKIYNTLAICHAGEIMGVVPKTYIPTYGVDFEGRWFSSGPADVTYITVAGQEHVPFGSHQVFRCCQMPQLCLGYEICEDIWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSM2</accession>
    <name>B8DSM2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29001">
        <property type="protein sequence ID" value="ACL29001"/>
        <property type="gene ID" value="BLA_0708"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0708"/>
    <dbReference type="HOGENOM" id="CLU_041900_3_3_11"/>
    <dbReference type="OMA" id="WWALWRA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_ISL3" evidence="1">
        <location>
            <begin position="174"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="443" mass="50175" checksum="A49F79C66A9B536C" modified="2009-03-03" version="1">MNEETRPEPEFSVFDPQRFLGLDEMGLRVLSWRRLGRPDGPGLRQIRCEPDSHDARWCPSCGAYARVRSSWLRTLAHVPYGDDAVHLLVRVRRYECVPCSRSWSDDPEAVGAGRGVLSVPAVMWALRRVCLDSMTVSACARLLHVAWAVVDRAVRERGMLLLEQADRFSSVRAIGVDEHVWRHGAFGDRYVTVIVDLTPRCDGRPARLLDMVPGRSAQVLREWMQARGGEFTRRVGVVAMDAFAGWKQAVESVVPHAVEVIDPFHVVQLAAARVTRVRCRLQRDATGRRGVKGDRLYDCRRALLTSDEYLGARGRARLMALFAIQANRDLMLAHDAYQRVIHAYRCDDGRRGERMMRELIDDLTGPGRYKGCRELASLGRVLKRRMRDILALFRHPRSSNGPTEAINGRLETLRGNAMGFANTTSYIQRCLIHSSQLKDILTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSM9</accession>
    <name>B8DSM9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Deoxyribonuclease/rho motif-related TRAM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BLA_0715</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218728.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0715"/>
    <dbReference type="EnsemblBacteria" id="ACL29008">
        <property type="protein sequence ID" value="ACL29008"/>
        <property type="gene ID" value="BLA_0715"/>
    </dbReference>
    <dbReference type="GeneID" id="66533476"/>
    <dbReference type="KEGG" id="bla:BLA_0715"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.746"/>
    <dbReference type="HOGENOM" id="CLU_014689_7_0_11"/>
    <dbReference type="OMA" id="FYAGDMK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="6">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="436" mass="48275" checksum="E111227B4CA212FB" modified="2009-03-03" version="1">MEATVDIERYADQGRCVAHIDGRVVFVRFALPGERVRIELDEPTNRNDRFWTGEVVEVLEPSPDRVEPLWPLAAPLAMGGGAGGADLIHVSLEGQERWKEATLKDVMKRLGHVDLDDVPVYAMPGDEQAHGLHWRTRIEMVTDDEGRPSMRRRGTHVRVPIDTMPLATRAVLEVAEMNGVWDGNLPENAQIRIAVPEPRVDAEQIADPEALRKAIGRNYAIMVDGKVRHGSRALKETIMVDGKPFEYTVDAGGFWQMHREAPMVLPQYVIDQIRETPGDRAPRNGRNLVIWDLYSGSGLFTLPLATLLDDRAKLVSIEGAKDAVANARRNLRNAGIHTVQALCGDVLHTLDKDIDPQRAHPDIVVLDPPRAGAKAKVCHKIANSGAPIVVYIACDPASLARDTATLTEHGYRIHSIAAFDIYPQTHHVETVAVFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSN0</accession>
    <name>B8DSN0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type Mn2+/Zn2+ transport systems, permease components</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218727.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0716"/>
    <dbReference type="EnsemblBacteria" id="ACL29009">
        <property type="protein sequence ID" value="ACL29009"/>
        <property type="gene ID" value="BLA_0716"/>
    </dbReference>
    <dbReference type="GeneID" id="66533477"/>
    <dbReference type="KEGG" id="bla:BLA_0716"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.747"/>
    <dbReference type="HOGENOM" id="CLU_075797_0_0_11"/>
    <dbReference type="OMA" id="WRTRNPG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016566">
        <property type="entry name" value="UCP010219"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11361">
        <property type="entry name" value="DUF3159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010219">
        <property type="entry name" value="UCP010219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="256" mass="28358" checksum="7F74857C2F2ECD98" modified="2009-03-03" version="1">MSNQNERHASNTRPARARSGMAALANAGENDEFSVIAAIGGVRGVVESMLPGLLFVVLFICTSDLRMTVIASAALAVVQVVVRLIQRQSVMGALGGLVAVGICLFWAWKSGEARNYYMYGFITNAAYIVLLLVSMAVRVPGLGFLVEFIRSLPTEHFKAWLSGWRSDRALYKAYARITWLWIGLFALRLIVQVPLYMTNQVGWLGTTRLVMGIPFWALAIWISYLIVADPLHRHRMLEKERESTSTEGGDAHPTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSP9</accession>
    <name>B8DSP9_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tyrosine recombinase XerC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">xerD</name>
        <name evidence="10" type="synonym">xerC</name>
        <name evidence="14" type="ordered locus">BLA_0735</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the 'phage' integrase family. XerC subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'phage' integrase family. XerD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218701.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0735"/>
    <dbReference type="EnsemblBacteria" id="ACL29028">
        <property type="protein sequence ID" value="ACL29028"/>
        <property type="gene ID" value="BLA_0735"/>
    </dbReference>
    <dbReference type="GeneID" id="66533496"/>
    <dbReference type="KEGG" id="bla:BLA_0735"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.766"/>
    <dbReference type="HOGENOM" id="CLU_027562_9_0_11"/>
    <dbReference type="OMA" id="HSFASHM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011932">
        <property type="entry name" value="Recomb_XerD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02225">
        <property type="entry name" value="recomb_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0229">DNA integration</keyword>
    <keyword evidence="8 10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="13">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="12">
        <location>
            <begin position="110"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACL29028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="307" mass="33978" checksum="47C77B0507D37241" modified="2009-03-03" version="1">MNGELPMLEARFLAHIDVERGLSAATVQAYENDIDQYVRWLGEQGIAKAASITSNDVEDFVAAQSKSGTSAVSLARRLASIHMFHRFMQSERVVADDVSQSVRPPKSAETLPEVLTVDEVQRLLDAARHDDASEAVSMRDSALLELMYATGCRVSEAVGLDFTDVDMDAQVVRLTGKGAKQRLVPFGTYAANALRAYVEHARPELENKAKGERERSAIFLNKRGKRLTRQSVWEIIKHAGALAHVSKPLHPHTLRHSFATHMLQGGADVRTVQELLGHASVKTTQMYTHVSQDTLIETYITSHPRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSR9</accession>
    <name>B8DSR9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable transcriptional repressor in the Rok (NagC/XylR) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218679.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0755"/>
    <dbReference type="EnsemblBacteria" id="ACL29048">
        <property type="protein sequence ID" value="ACL29048"/>
        <property type="gene ID" value="BLA_0755"/>
    </dbReference>
    <dbReference type="GeneID" id="66533515"/>
    <dbReference type="KEGG" id="bla:BLA_0755"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.786"/>
    <dbReference type="HOGENOM" id="CLU_036604_13_1_11"/>
    <dbReference type="OMA" id="ELCECGK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="401" mass="42926" checksum="9DDE43B212AF2933" modified="2009-03-03" version="1">MNSRTTTEQQTLSEYNRARTLQYLHHHGIASRAQIAKALHLTPAALSKISNHLLASGAIVETGALEGKGNRRSIGLAVNARAFQVLGVKFARSLIEIGLFDLAGKPSFIRELPTVENTTIPQAIESLHAEIRRLLAEHPHILAIGMAVPGPYLRDRGHTAVVSSMGQWRQVNFRAEFEHAFDVPVIIEQDARAGALAQYLFDPNPANENLAYYLLGEGIGLGVIDHGTVINGSLGAATEIGHVSIDVNGKACDCGNVGCLERYCSAVAIHEAMLGNGMLATDSRLTHREACAELFARAQSGDGQARELVERIGTFVGYGCVTICNAFNPSRIVIGDIVAQAGEPLLQRVREVVGERVIPEITQSTQIELSALPTDAAVTGAAAVAITYILDHPSQFFASGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSU0</accession>
    <name>B8DSU0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable FtsW-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fstW</name>
        <name evidence="8" type="ordered locus">BLA_0777</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218649.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0777"/>
    <dbReference type="EnsemblBacteria" id="ACL29069">
        <property type="protein sequence ID" value="ACL29069"/>
        <property type="gene ID" value="BLA_0777"/>
    </dbReference>
    <dbReference type="GeneID" id="66533539"/>
    <dbReference type="KEGG" id="bla:BLA_0777"/>
    <dbReference type="HOGENOM" id="CLU_029243_0_2_11"/>
    <dbReference type="OMA" id="KLWWSNL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="460" mass="49390" checksum="7892F0794E464263" modified="2009-03-03" version="1">MDMPKPERQPRSMRSAQDGKSSGAIPSVKPLVRRSRRSGAPQPWTVTHDDPATAARIASKRPSPQFGMIDFAGEYKGWRVLLNPLGCYYGFIVAVGILTVFGIIMVFSSSSVDMVAAGSSPWAKALNQVGFSVVGLVLALVAAHCKGRTLKWLALPMYLVSVAVQVFTFFFGIDVGGNRGWLRIAGIQFQPAEFMKFTICLWFPLVMISMMRLKPGIRQSWKAWDLGDWGRTFGLYVLGLGSVLLGKDLGTALVIILIGLMAIVASGFPMKYVGLVGIAAVVGVAILTVFSSNRMSRIMATYTGCTADNIDVCYQATHSNYALASGGLLGVGLGNSREKWNYLPAAHNDFIFAIIGEETGFVGAALVVLLFVVIAWCLVAVAMQMHNRYASVALLCFMMWIVGQALINIAVVVEILPVMGVPLPFVSAGGSSMIFCLMAAGACVSLMRAQPQIGAAHSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSW8</accession>
    <name>B8DSW8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218607.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29097">
        <property type="protein sequence ID" value="ACL29097"/>
        <property type="gene ID" value="BLA_0805"/>
    </dbReference>
    <dbReference type="GeneID" id="66533567"/>
    <dbReference type="KEGG" id="bla:BLA_0805"/>
    <dbReference type="HOGENOM" id="CLU_2285965_0_0_11"/>
    <dbReference type="OMA" id="VIPTCAM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="101" mass="10650" checksum="ECED6D74E1912158" modified="2009-03-03" version="1">MTASKPARGRRIAVYVALIPLCALLALPGAIGMVQAIRILLGCDHAAGYSTGVRELEAWTSLLFTTPLAVMPTCAMIIFVVLAITEASRGKSPPSSPSRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSZ9</accession>
    <name>B8DSZ9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218563.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0836"/>
    <dbReference type="EnsemblBacteria" id="ACL29128">
        <property type="protein sequence ID" value="ACL29128"/>
        <property type="gene ID" value="BLA_0836"/>
    </dbReference>
    <dbReference type="GeneID" id="66533598"/>
    <dbReference type="KEGG" id="bla:BLA_0836"/>
    <dbReference type="HOGENOM" id="CLU_168842_2_0_11"/>
    <dbReference type="OMA" id="KIGVQHA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021456">
        <property type="entry name" value="DUF3107"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11305">
        <property type="entry name" value="DUF3107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="75" mass="8150" checksum="1A3D0C9B8EA07A5F" modified="2009-03-03" version="1">MDIEIGIQNVARTVTFTTDEAAETVTATIDRALEEHKPIVLTDNKDRRIIVPADSLGYVIVGSEQRHAVGFGNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT05</accession>
    <name>B8DT05_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Band 7 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0842</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218552.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0842"/>
    <dbReference type="EnsemblBacteria" id="ACL29134">
        <property type="protein sequence ID" value="ACL29134"/>
        <property type="gene ID" value="BLA_0842"/>
    </dbReference>
    <dbReference type="GeneID" id="66533604"/>
    <dbReference type="KEGG" id="bla:BLA_0842"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.876"/>
    <dbReference type="HOGENOM" id="CLU_024949_5_0_11"/>
    <dbReference type="OMA" id="AMTQQMK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="3">
        <location>
            <begin position="21"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="302" mass="33367" checksum="B92222D25B4DEA39" modified="2009-03-03" version="1">MSPSLIGIGVIALVVIVLLCMAIYVVPQQQAYIIERFGKFRSVRFAGIHLLIPFVDRIAMKTNMRVSQLNVKLETKTLDNVFVTIVASTQYRVNPDNVAKAYYELRDPQGQLRSYMEDALRSAIPMLTLDDAFARKDSVAADVQQTVGSEMARFGFTVVKTLITAIDPSPAVKSAMDSINAAQREKEATRQHAEAMRIQIETQAAAEAEKVRLQGEGQANYRREIADGIVDQIKSLQEVGMDIGAVNNVVLFNQYLDVLRSLSESKNAKTLVMPAATPGGYSELFDQMTQAMLTTQESSPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT29</accession>
    <name>B8DT29_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Allergen V5/Tpx-1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219223.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="SMR" id="B8DT29"/>
    <dbReference type="STRING" id="442563.BLA_0866"/>
    <dbReference type="EnsemblBacteria" id="ACL29158">
        <property type="protein sequence ID" value="ACL29158"/>
        <property type="gene ID" value="BLA_0866"/>
    </dbReference>
    <dbReference type="GeneID" id="66533844"/>
    <dbReference type="KEGG" id="bla:BLA_0866"/>
    <dbReference type="HOGENOM" id="CLU_130822_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLH" evidence="1">
        <location>
            <begin position="46"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="1">
        <location>
            <begin position="113"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="175" mass="19649" checksum="16342F0D2B605F45" modified="2009-03-03" version="1">MISNVRGGKIENGVAMPDKLNGSVTYRYTYDYTHEPLKAEITFTPSVWFTDVNVYSTPHAVDIQWLADNKITTGWLVNGCYVFRGMDNVKRRDMAAFLHRLAAKAGKGTNVTPKNNFKDVNAKTPHVADIQWLAGAGVTEGWKVGNSYEFRGMNNVVRQDMAAFLHHLNDKVLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT39</accession>
    <name>B8DT39_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Possible ATP binding protein of ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0876</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219235.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0876"/>
    <dbReference type="EnsemblBacteria" id="ACL29168">
        <property type="protein sequence ID" value="ACL29168"/>
        <property type="gene ID" value="BLA_0876"/>
    </dbReference>
    <dbReference type="GeneID" id="66533855"/>
    <dbReference type="KEGG" id="bla:BLA_0876"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.916"/>
    <dbReference type="HOGENOM" id="CLU_782269_0_0_11"/>
    <dbReference type="OMA" id="CYSGHAY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="137"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="354" mass="38478" checksum="3E074B962FEBB974" modified="2009-03-03" version="1">MTEHHDSKDTDSKDTPTTPQENASENAAPDTFDYVVDYWDDEGSASNDSSDAVIEALSATVDANATDPTDGDTDADGEPAADKSRETAPAHSNENAQVTVPDVVQVADHLDSSLQAEEDGEDAALAGSSIFRAYPMLSLHDVTVSDPKTKEHIWQHLTFRCEAGECYAIMVDAHDTRRHATLLALIGGFIAPSSGEIMTKTTPYEDMDAEQLRGHRLGMITPQFSLRGDLNAVENLTYVMNASGQTFMKPVKGLAQDLLVRTRFGENTKADESTLADELDPVDAARLSIARALAIDPDYIIADNLTVNLNETDTKQVLNLLKAQVSTPDKQRTVIVVTASEQIAKQFDNIIDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT70</accession>
    <name>B8DT70_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosilase</fullName>
            <ecNumber evidence="2">3.2.1.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.20" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219257.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0907"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29199">
        <property type="protein sequence ID" value="ACL29199"/>
        <property type="gene ID" value="BLA_0907"/>
    </dbReference>
    <dbReference type="GeneID" id="66533887"/>
    <dbReference type="KEGG" id="bla:BLA_0907"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.950"/>
    <dbReference type="HOGENOM" id="CLU_006462_2_3_11"/>
    <dbReference type="OMA" id="DYYIFAG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032450">
        <property type="term" value="F:maltose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="18"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="534" mass="59488" checksum="9C0A2A5077B9CCB5" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTC8</accession>
    <name>B8DTC8_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Formate acetyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.54</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pyruvate formate-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pflB</name>
        <name evidence="11" type="ordered locus">BLA_0967</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>acetyl-CoA + formate = CoA + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:11844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Fermentation; pyruvate fermentation; formate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.54" evidence="8"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217631.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="SMR" id="B8DTC8"/>
    <dbReference type="STRING" id="442563.BLA_0967"/>
    <dbReference type="EnsemblBacteria" id="ACL29257">
        <property type="protein sequence ID" value="ACL29257"/>
        <property type="gene ID" value="BLA_0967"/>
    </dbReference>
    <dbReference type="GeneID" id="66533422"/>
    <dbReference type="KEGG" id="bla:BLA_0967"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1010"/>
    <dbReference type="HOGENOM" id="CLU_023898_0_0_11"/>
    <dbReference type="OMA" id="PYGGIKM"/>
    <dbReference type="UniPathway" id="UPA00920">
        <property type="reaction ID" value="UER00891"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008861">
        <property type="term" value="F:formate C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01678">
        <property type="entry name" value="PFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005949">
        <property type="entry name" value="Form_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019777">
        <property type="entry name" value="Form_AcTrfase_GR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001150">
        <property type="entry name" value="Gly_radical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004184">
        <property type="entry name" value="PFL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01228">
        <property type="entry name" value="Gly_radical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02901">
        <property type="entry name" value="PFL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01255">
        <property type="entry name" value="pyr_form_ly_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00850">
        <property type="entry name" value="GLY_RADICAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51149">
        <property type="entry name" value="GLY_RADICAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51554">
        <property type="entry name" value="PFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="5 7 8" id="KW-0556">Organic radical</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFL" evidence="10">
        <location>
            <begin position="14"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine radical" evidence="9">
        <location>
            <begin position="666"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycine radical" evidence="7">
        <location>
            <position position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL29257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="792" mass="89369" checksum="0897C4023F0389FF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTD0</accession>
    <name>B8DTD0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ribonuclease D</fullName>
            <ecNumber evidence="2">3.1.13.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.13.5" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0969"/>
    <dbReference type="EnsemblBacteria" id="ACL29259">
        <property type="protein sequence ID" value="ACL29259"/>
        <property type="gene ID" value="BLA_0969"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0969"/>
    <dbReference type="HOGENOM" id="CLU_042387_3_0_11"/>
    <dbReference type="OMA" id="FMRVDTF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033890">
        <property type="term" value="F:ribonuclease D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041605">
        <property type="entry name" value="Exo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18305">
        <property type="entry name" value="DNA_pol_A_exoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HRDC" evidence="1">
        <location>
            <begin position="228"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="430" mass="49266" checksum="38C45126E0EB0E8D" modified="2009-03-03" version="1">MNKEPVLQTEPKEGVPEVTDTLAGFELICEQYAAVNTPLATDAERASGYRYGHEDWLIQFKRDGAPIALLDPIALDEQGVDWNAFNEAVGDAEWILHDSRQDLPGFAQIGLKPRRLFDTEIAAKLLGLHRVGLAYVTAHFLGITLAKEHSAADWSYRPLPRDWRNYAALDVELLSDLERAMTHELKRQGKWEWAQEEFDYALHEGLQPPKPHPVPWMRISHINVLQRDRRGLAVAKALWTERDRLAREYDISPSLLLADSAIIEAAQRKPHNASQFRAVRSLNERVRMHLGNEQDKMFERYAPIQRKVKPSLWKRTIQEALDLPSDELPELPGKAAGHGEDVVNAPRSAKFWQTHEPKRYRQLQRCKAVLNQISQDTCTPTDVLLKPQILRNLCWTDHPHRRDVAQFLAQQGARPWQVDLLSESLSRAIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTE1</accession>
    <name>B8DTE1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Succinate dehydrogenase flavoprotein subunit</fullName>
            <ecNumber evidence="11">1.3.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">sdhA</name>
        <name evidence="11" type="ordered locus">BLA_0980</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.1" evidence="11"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269123.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0980"/>
    <dbReference type="EnsemblBacteria" id="ACL29270">
        <property type="protein sequence ID" value="ACL29270"/>
        <property type="gene ID" value="BLA_0980"/>
    </dbReference>
    <dbReference type="GeneID" id="66533407"/>
    <dbReference type="KEGG" id="bla:BLA_0980"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1023"/>
    <dbReference type="HOGENOM" id="CLU_014312_6_2_11"/>
    <dbReference type="OMA" id="DPIPIQP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="9">
        <location>
            <begin position="11"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="10">
        <location>
            <begin position="498"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL29270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="619" mass="66322" checksum="CB416DCF9A1FF2C0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTH4</accession>
    <name>B8DTH4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate ammonia-lyase</fullName>
            <ecNumber evidence="3">4.3.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ansB</name>
        <name evidence="3" type="ordered locus">BLA_1013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1013"/>
    <dbReference type="EnsemblBacteria" id="ACL29303">
        <property type="protein sequence ID" value="ACL29303"/>
        <property type="gene ID" value="BLA_1013"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1013"/>
    <dbReference type="HOGENOM" id="CLU_021594_4_1_11"/>
    <dbReference type="OMA" id="EICENYV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008797">
        <property type="term" value="F:aspartate ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="1">
        <location>
            <begin position="40"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="2">
        <location>
            <begin position="437"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="511" mass="55257" checksum="0000A1B753B77359" modified="2009-03-03" version="1">MECLRECGTADRRACGKEKADSMDSTRQAAETRLEHDVIGTMEIPADVYWGIHTQRAMGNFTVTGIADGSHTALIRAYATVKRACAIANYQLGMLDARKAHHIEQACLEIENGALADQFPVDVLQGGAGTSLNMNMNEVIANRALELAGKPRGDYGYIHPNDDVNRSQSTNDTYPAACRLAILQGLKPLREATQRLREAFHMQADRHSNDIKIGRTQLQDAVPMTYGQEIHAWASFLATDLEAMNTLAKRLCVFNLGATAIGTGICADLRFRHTATTVLAEITDLPITAASDPVAAVTDTSSYIEASAVLKNLAVHLKKAADDLRLLNSGPRCGFGDLTVPPRQAGSSIMPGKINPVIPECVDQCCFTIFGMDVTVNWACAEGQLQLNAFDPLIIHEILTAMTIAINAMDMFRTKCVDGLRINVEQGRRDAEMSPSICAALNGKIGYEQAMSIAKEAVATGKSVREVAGERTDADRTELDSLLDIAAMSRKLGQTCRDVDADGNVISPTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTJ0</accession>
    <name>B8DTJ0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative septum formation initiator subfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217716.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1031"/>
    <dbReference type="EnsemblBacteria" id="ACL29319">
        <property type="protein sequence ID" value="ACL29319"/>
        <property type="gene ID" value="BLA_1031"/>
    </dbReference>
    <dbReference type="GeneID" id="66533358"/>
    <dbReference type="KEGG" id="bla:BLA_1031"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1078"/>
    <dbReference type="HOGENOM" id="CLU_085342_1_0_11"/>
    <dbReference type="OMA" id="RRVFSCD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007060">
        <property type="entry name" value="FtsL/DivIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04977">
        <property type="entry name" value="DivIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="190" mass="20473" checksum="7481777FC5FC62D6" modified="2009-03-03" version="1">MSKRPHVSKPQSAPSSSKKERTHTKGANTGPIAFFIALFVIAVGSIQIISAFHTYAINLSELNSLKKQEAVLAAQKKDLENDIARWDDPAYVTAQARERLGYVFPGEQAIKVEHPEAVSGEQPKSDANANTETGQSNLPWYSELAYSFKESDARKPDATNNGNTAESRQQNDPDATAGTDAPQDGGSAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTJ6</accession>
    <name>B8DTJ6_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">greA</name>
        <name evidence="11" type="ordered locus">BLA_1037</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GreA/GreB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217724.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1037"/>
    <dbReference type="EnsemblBacteria" id="ACL29325">
        <property type="protein sequence ID" value="ACL29325"/>
        <property type="gene ID" value="BLA_1037"/>
    </dbReference>
    <dbReference type="GeneID" id="66533351"/>
    <dbReference type="KEGG" id="bla:BLA_1037"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1084"/>
    <dbReference type="HOGENOM" id="CLU_101379_0_0_11"/>
    <dbReference type="OMA" id="TWLTQEA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00830">
        <property type="entry name" value="GREAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="10">
        <location>
            <begin position="9"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="9">
        <location>
            <begin position="84"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL29325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="160" mass="17514" checksum="46E023E76EE3CB43" modified="2009-03-03" version="1">MEQEEKVVLLTQEAYDKMKEELAHREGEYRDEITERIAAARAEGDLSENGGYQAAREEQSKNEGRINELIVKLRNAKIIEAPKAGEVGNGSLVTIELGGNEMQYVIGSRDITVATDYDVISPESPIGGAIIGHKVGDVVTYKAPNGREISVTIKESEPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTK0</accession>
    <name>B8DTK0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_1041</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619918.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1041"/>
    <dbReference type="EnsemblBacteria" id="ACL29329">
        <property type="protein sequence ID" value="ACL29329"/>
        <property type="gene ID" value="BLA_1041"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1041"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1088"/>
    <dbReference type="HOGENOM" id="CLU_031357_0_0_11"/>
    <dbReference type="OMA" id="SIMMYIA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="3">
        <location>
            <begin position="149"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="167"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="578" mass="63177" checksum="C729925D423D47D9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTK7</accession>
    <name>B8DTK7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beta-xylosidase</fullName>
            <ecNumber evidence="8">3.2.1.37</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">xynB</name>
        <name evidence="8" type="ordered locus">BLA_1048</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="8"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219350.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1048"/>
    <dbReference type="CAZy" id="GH43">
        <property type="family name" value="Glycoside Hydrolase Family 43"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29336">
        <property type="protein sequence ID" value="ACL29336"/>
        <property type="gene ID" value="BLA_1048"/>
    </dbReference>
    <dbReference type="GeneID" id="66532877"/>
    <dbReference type="KEGG" id="bla:BLA_1048"/>
    <dbReference type="HOGENOM" id="CLU_016508_2_1_11"/>
    <dbReference type="OMA" id="LVNYYNT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH43_C2" evidence="7">
        <location>
            <begin position="335"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="541" mass="61774" checksum="404221737E5837F2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTL6</accession>
    <name>B8DTL6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sua5/YciO/YrdC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218750.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1057"/>
    <dbReference type="EnsemblBacteria" id="ACL29345">
        <property type="protein sequence ID" value="ACL29345"/>
        <property type="gene ID" value="BLA_1057"/>
    </dbReference>
    <dbReference type="GeneID" id="66532886"/>
    <dbReference type="KEGG" id="bla:BLA_1057"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1105"/>
    <dbReference type="HOGENOM" id="CLU_031397_3_1_11"/>
    <dbReference type="OMA" id="GMLKSHY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="222" mass="22972" checksum="7E8BF7537A0DE48B" modified="2009-03-03" version="1">MADVRSADEQTLADARRIIADGGLVVIPTDTVYGIACDPCNAAAIARIYAAKHRPADKALQVIMPDLSVLPKLGLALPTPLDALARRFLPGAFSPIAVADDDSPLLTVRVDDSGARTQGIRVPDSEVTLRVLRAIGPVAASSANRSGNESAQTVDEAVAALGDSVDLYIDGGPTVSHTASTVVAADPDAPDGIVILREGRLEADAVRRAVREEARHGGTAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTM6</accession>
    <name>B8DTM6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1067"/>
    <dbReference type="EnsemblBacteria" id="ACL29355">
        <property type="protein sequence ID" value="ACL29355"/>
        <property type="gene ID" value="BLA_1067"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1067"/>
    <dbReference type="HOGENOM" id="CLU_1764454_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="147" mass="15818" checksum="6D430B7DCE14A807" modified="2009-03-03" version="1">MWHSRLVLEASNVGLDLNYVVTMSMRTPREGYTGQQAPSQMASDEQGSPMRPQTQQATSAAPQSTLSRSSMAPGDDGGNPVDPFNQMPPDCLSPDAAASMPQQGDQRDAALEPLVGNGMPPQDLEHGCATDTTNSRKEVRPEDQDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTN0</accession>
    <name>B8DTN0_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gltA</name>
        <name evidence="6" type="ordered locus">BLA_1071</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218767.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1071"/>
    <dbReference type="EnsemblBacteria" id="ACL29359">
        <property type="protein sequence ID" value="ACL29359"/>
        <property type="gene ID" value="BLA_1071"/>
    </dbReference>
    <dbReference type="GeneID" id="66532898"/>
    <dbReference type="KEGG" id="bla:BLA_1071"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1120"/>
    <dbReference type="HOGENOM" id="CLU_025068_0_0_11"/>
    <dbReference type="OMA" id="TVGWCAQ"/>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="430" mass="48379" checksum="9904BCD08B11ECE4" modified="2009-03-03" version="1">MGEAHLHVEADEFKLPVVKATAGPDGIVMSSLRNNNWVSLDPGFLTTAQCESRITYIDGEHSILRYRGYPIEQLCEQSDFLEVSWLLRNGELPTKAEYNRFVEDINHHTMVGEDFRTFMGSFPRGAQPMSVMASAINALAAFNPDTTDISDPEQLDEAAMIIMAKARTVVSYILRRRRDEPMLYPDYARGYVDDFIRMCFAVPYERFESDPLYVHAFGRLLIIHADHEQNCSTSVVRIAGSAHANLYSAVAAGINALSGPRHGGANEAVLRQLMAIRDSGMSVKQFVEKAKVEGSRISGLGHRVYKSYDPRAAIAKHYLEKIMENKATLKLLPGDEQLFDVALQLEDIALNDDYFVSRNLYPNVDFYTGLIYRAIGFGPSMFTPLFALGRIPGWIAQYREMLADPMTKIGRPRQVYTGAVLRDYVPIDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTP3</accession>
    <name>B8DTP3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CTP synthase (UTP-ammonia lyase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1084"/>
    <dbReference type="EnsemblBacteria" id="ACL29372">
        <property type="protein sequence ID" value="ACL29372"/>
        <property type="gene ID" value="BLA_1084"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1084"/>
    <dbReference type="HOGENOM" id="CLU_052626_4_2_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="102" mass="11936" checksum="6640D411C4A0451C" modified="2009-03-03" version="1">MVPELQISFFDPVTRKTYRTDYLWRLADGRAIVGEFDGMEKYVNPQMVGSKTIEQRVLAERERDEALRRCGVSQIVHFSYNDVMHPDQLRRKLEQAGVPYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTP5</accession>
    <name>B8DTP5_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2 8">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">glmS</name>
        <name evidence="11" type="ordered locus">BLA_1086</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2 8"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269062.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1086"/>
    <dbReference type="EnsemblBacteria" id="ACL29374">
        <property type="protein sequence ID" value="ACL29374"/>
        <property type="gene ID" value="BLA_1086"/>
    </dbReference>
    <dbReference type="GeneID" id="66532912"/>
    <dbReference type="KEGG" id="bla:BLA_1086"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1140"/>
    <dbReference type="HOGENOM" id="CLU_012520_5_2_11"/>
    <dbReference type="OMA" id="ASEYRYA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 11" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="296"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="475"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="8">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="8">
        <location>
            <position position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL29374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="630" mass="68471" checksum="7E55132996CDB934" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTQ2</accession>
    <name>B8DTQ2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable ATP-binding protein of ABC transporter system for peptides</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">oppD</name>
        <name evidence="5" type="ordered locus">BLA_1093</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218804.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1093"/>
    <dbReference type="EnsemblBacteria" id="ACL29381">
        <property type="protein sequence ID" value="ACL29381"/>
        <property type="gene ID" value="BLA_1093"/>
    </dbReference>
    <dbReference type="GeneID" id="66532919"/>
    <dbReference type="KEGG" id="bla:BLA_1093"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1147"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_11"/>
    <dbReference type="OMA" id="PEIDRKW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="265" mass="28136" checksum="64504435CD8757FE" modified="2009-03-03" version="1">MSVDLQSVNVSIAGRQIVRDVCLQIRDGQRVGLIGSSGSGKSMIARAIMGLLPQDTQLSGSINVNGTQTVGMNDVQLARLRGAAMGMVFQNPAASLNPLLRVREQIELPLKLHYDLPAQDRAERVANMAAKVGLPADVLDRFPHQLSGGQQQRVSIATALITSPRLIIADEPTTALDSITQQQILELLVGLVDEAGASMLFVTHDFSVLASATQYCYVLREGSIVDAGRTDALLADPADEYTAMLVTAARALSLHVDGSGGANHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTS3</accession>
    <name>B8DTS3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_1114</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1114"/>
    <dbReference type="EnsemblBacteria" id="ACL29402">
        <property type="protein sequence ID" value="ACL29402"/>
        <property type="gene ID" value="BLA_1114"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1114"/>
    <dbReference type="HOGENOM" id="CLU_044754_2_0_11"/>
    <dbReference type="OMA" id="IHNMPFP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016205">
        <property type="entry name" value="Glycerol_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43616">
        <property type="entry name" value="PTHR43616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="3">
        <location>
            <begin position="40"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="385" mass="41853" checksum="6519186482EDE588" modified="2009-03-03" version="1">MNPDHCRSAAACHLYISVSSRKEQHTHGNQCSGFRRPSRPNRYISTPGVAKEVRKYIEDYDHPVIITGVKSADAFLDYTGEDEFFAPVLRYDGSSSERNARELAEQAKALDADAIIAIGAGKLSDTAKNVAEMMDVDLIIVPTLACACAAYSPYSVDYDDEHRFLGVPVHPRNSVALLVDSAMIAQTPPEKFIGGIGDTIAKFYESDPVFAQADDLTVFDQLSRQSARLVRDTLLSESEPALDALNQGAYDDPHVRTLIDTIIGIAGTVGGFGGVRARESGAHTVHDGLTRIPGSAETMHGEKVAYGVLVQLITEGKEDEARDLLPFYNKIGLPHSWKQMNLPFTDENLKTVADFAADPGSPFHAAVPDVTADQIIDAMRTVEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTT5</accession>
    <name>B8DTT5_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="6">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">purD</name>
        <name evidence="9" type="ordered locus">BLA_1126</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GARS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="6"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218846.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1126"/>
    <dbReference type="EnsemblBacteria" id="ACL29414">
        <property type="protein sequence ID" value="ACL29414"/>
        <property type="gene ID" value="BLA_1126"/>
    </dbReference>
    <dbReference type="GeneID" id="66532950"/>
    <dbReference type="KEGG" id="bla:BLA_1126"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1180"/>
    <dbReference type="HOGENOM" id="CLU_027420_3_1_11"/>
    <dbReference type="OMA" id="KATVCKY"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="108"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL29414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="420" mass="44842" checksum="158510446CCCD870" modified="2009-03-03" version="1">MKVLVIGSGAREHAIAYTLLKGASVEEVTVAPGNPGMELDGIRTLSLNPSNQAALIDFVRNNDYDWVFVGPEVPLIEGIVDALAAAGIKAFGPSKAAAQIEGSKDFAKRLMERHNIPTAAYRTFDDLRSATDYVNEHGAPIVVKADGLAAGKGVTVAMDVETALDALNDIFVDHRFGSAGARVVIEDYLEGQEFSLMSFVNGTEFWPMPISQDHKRAYDNDEGPNTGGMGAYSPVPQIGQDVVDEALETIVKPTVEAMASEGTPFVGILYAGLIATADGPKVIEFNARFGDPETEVILPRLHSDLGQAIQAMLDGEAPEFTWLEEGTTLGVVLAADGYPTNVLKGAKVPQFKTGTDSHVFYAGVKREGDDLVADSGRVLLVEVSADDIPSARKKVYEILDNADTAGMFYRHDIGAKALQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTU3</accession>
    <name>B8DTU3_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218857.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1134"/>
    <dbReference type="EnsemblBacteria" id="ACL29422">
        <property type="protein sequence ID" value="ACL29422"/>
        <property type="gene ID" value="BLA_1134"/>
    </dbReference>
    <dbReference type="GeneID" id="66532958"/>
    <dbReference type="KEGG" id="bla:BLA_1134"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1188"/>
    <dbReference type="HOGENOM" id="CLU_1375866_0_0_11"/>
    <dbReference type="OMA" id="NMEIWRS"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="198" mass="22006" checksum="C7CA0293E575C769" modified="2009-03-03" version="1">MDAHELTQAAFVSELNKQYLSRFHQKDVSRWLNSGNKTSTGTIGFPKYETMAMIADFFGVDVGYLTGETDETSFDLEHASEYLGMSGESVAALRGWIIGEDADSQMRNYRSETLNALFESPKFASVASKLLTLHEMSTLWKSNPERFNTLMESLASDSDLPDDLTFQLIIGAFYGMASESFSTLLKDAYPTPTEQATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTU4</accession>
    <name>B8DTU4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218861.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1135"/>
    <dbReference type="EnsemblBacteria" id="ACL29423">
        <property type="protein sequence ID" value="ACL29423"/>
        <property type="gene ID" value="BLA_1135"/>
    </dbReference>
    <dbReference type="GeneID" id="66532959"/>
    <dbReference type="KEGG" id="bla:BLA_1135"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1191"/>
    <dbReference type="HOGENOM" id="CLU_590085_0_0_11"/>
    <dbReference type="OMA" id="IMSITIQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="512" mass="54981" checksum="DD4C12025F816F3F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTY8</accession>
    <name>B8DTY8_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218929.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1179"/>
    <dbReference type="EnsemblBacteria" id="ACL29467">
        <property type="protein sequence ID" value="ACL29467"/>
        <property type="gene ID" value="BLA_1179"/>
    </dbReference>
    <dbReference type="GeneID" id="66533004"/>
    <dbReference type="KEGG" id="bla:BLA_1179"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1238"/>
    <dbReference type="HOGENOM" id="CLU_054927_0_0_11"/>
    <dbReference type="OMA" id="RSDEIGM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="1">
        <location>
            <begin position="51"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="321" mass="35682" checksum="C00834B6969F4CF2" modified="2009-03-03" version="1">MIGTNHDANRSDPIRRKIEMLGTSLSLPTVRRAMGILEGEHASARRGGNDDLLDIRAYEVGDEARQIDWKISARNGRAMIAQRERLSSTRVYLLLDAGVEMTEVCPSDEMAYRIAANALCMFAALSLRRSDEVSLVFGDSSNITRVPFHGGLAQFEHTLDKALDRGWRFPRNIDALLDYAAHIRDREALIVLATDDHALDDTHMRAIRRITQTHPLVLINVGTINPFSSDPIPSRPHASLVDGATDRRIPAFLRNTKAAQELDTHRAYLLQALDRELLRCGSRMIHASSSEGMFHAFVRLLSLSHASVFTPVTIPEGTANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU16</accession>
    <name>B8DU16_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BLA_1207</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29495">
        <property type="protein sequence ID" value="ACL29495"/>
        <property type="gene ID" value="BLA_1207"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1207"/>
    <dbReference type="HOGENOM" id="CLU_036805_8_2_11"/>
    <dbReference type="OMA" id="YCKARVG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="319" mass="36372" checksum="3FC8123874F98ACC" modified="2009-03-03" version="1">MELEADELLGEGNRRNGYRERRLRTVIGEIVLRVPKPREDTYFPERVMRPYSRVDRAMVGVVYRAYVNGMSTRRIEKVADELESGRLSPSTVSRMRASLDGEVDALRQAEFDAGSPVQYLWLDATYVKCRDDDSRVCSQATVTAIGAFMDGTRRFVGFDLVDTESYDSWKRFLLSLRRRGVAGVRLVTSDAHAGLRRAIMEVFDGASWQRCFVHMQRDLTARIRHRKDQGRAMHALSAVPRQPDAAMTRAAYDAAVVRIGAIDRRAGELLEDAREDALAHLAFHREHWVRLRTNNVQERANAEIKRRTRAVQSSPHASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU43</accession>
    <name>B8DU43_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1234"/>
    <dbReference type="EnsemblBacteria" id="ACL29522">
        <property type="protein sequence ID" value="ACL29522"/>
        <property type="gene ID" value="BLA_1234"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1234"/>
    <dbReference type="HOGENOM" id="CLU_663364_0_0_11"/>
    <dbReference type="OMA" id="WNARASQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="45"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="454" mass="48797" checksum="1C08153F0BA7FBD8" modified="2009-03-03" version="1">MQAAWNARASQEPAGCSRTRWVWRNAPRSITWCSRCSPKGMDRRQTQPQALEAMRLFDLDYAADRRFSELSGGEAQRLMLARAVCSRPDMLLVDEPTAQLDTRTAHSVSHVLGNLANQGMIVLVATHDPDTRDACARNRSGLLCARGGRGRVGMGLRSIFSEAIRNIGSGTAHALALFLVVLLGGVLLGGYEAYTVVAMECESLTRVRAVADVDSVIGGTVDGSACDRLTRTTDGAITQAGAMRAGGEITALSTPNNALQSYEVTPGMLSLVASNGTTTDSIDMSGIWVPTEVARDFGLTIGSTLSTSHGEAMVAGIYSWPNDGRDTRFAYTFLVPRAASQGTYNECWVRQWPRSGAASNLLYSTLGVGEGSGQAGVTSLDKGFDSHYDPYATYMGRVTHWIPYLSILIGVVIGVLAVRVRRLEYAAALHSGSRSRRCCSASARRCSSGPDWEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU50</accession>
    <name>B8DU50_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Possible rRNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1241"/>
    <dbReference type="EnsemblBacteria" id="ACL29529">
        <property type="protein sequence ID" value="ACL29529"/>
        <property type="gene ID" value="BLA_1241"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1241"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1304"/>
    <dbReference type="HOGENOM" id="CLU_021322_3_2_11"/>
    <dbReference type="OMA" id="FLAEGPQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="2">
        <location>
            <begin position="35"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="SpoU_methylase" evidence="1">
        <location>
            <begin position="132"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="292" mass="31922" checksum="ACCF7530CDB9AC2A" modified="2009-03-03" version="1">MPIDQQVLTNTKAERIRRISELTNRKHRQKAGKFLIEGPQCVREALTWQPQIIQDVYVRTDGADPDSPIASTALGKLAGEAMEERIHVHKMTQEVEHRVSHDAQGVFAVADLNSCRDLLGRVPQTPHPFLAAFWQMRDPGNAGTVIRSADAAGCDAVVLVGDCVDIFNPKVIRATTGSLFHLPVLAMDERAFFDLCRERDTTVLAADVYGTEGKPPVSLPDLLRNRELVEGSKAVLFGNEARGLTTELLDECAMSVSIPIYGKAESLNLGTSAAVMLTTLAMSSRIETMGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU65</accession>
    <name>B8DU65_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Superfamily II DNA and RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218067.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1256"/>
    <dbReference type="EnsemblBacteria" id="ACL29544">
        <property type="protein sequence ID" value="ACL29544"/>
        <property type="gene ID" value="BLA_1256"/>
    </dbReference>
    <dbReference type="GeneID" id="66533078"/>
    <dbReference type="KEGG" id="bla:BLA_1256"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1319"/>
    <dbReference type="HOGENOM" id="CLU_023500_0_0_11"/>
    <dbReference type="OMA" id="QGRRWEN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="555" mass="63803" checksum="94FB0FE3AB733877" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU92</accession>
    <name>B8DU92_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="6">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tsaD</name>
        <name evidence="8" type="synonym">gcp</name>
        <name evidence="8" type="ordered locus">BLA_1284</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="6"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218031.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1284"/>
    <dbReference type="EnsemblBacteria" id="ACL29571">
        <property type="protein sequence ID" value="ACL29571"/>
        <property type="gene ID" value="BLA_1284"/>
    </dbReference>
    <dbReference type="GeneID" id="66533109"/>
    <dbReference type="KEGG" id="bla:BLA_1284"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1346"/>
    <dbReference type="HOGENOM" id="CLU_023208_0_2_11"/>
    <dbReference type="OMA" id="HLEGHIY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="7">
        <location>
            <begin position="26"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="136"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="347" mass="36156" checksum="EC4BEC4C1AC25D99" modified="2009-03-03" version="1">MSNQIILGIESTCDETAAAVVQGKTLLANVVASSMDEHARYGGVIPEIASRAHAQSFVPVVSKALADANMTIDDVDAIAVSAGPGLAGCLAVGVSGAKALAWSANKPIYGINHVIGHVAVTQLQFGDLPANTMALIVSGGHTSLLHVNDIARDVEVVGTTLDDAAGECFDKVARLLGFPYPGGPYIDRHAQHGDPHAIKVPQGLTQGRAGKEHPYDFSFSGVKTAIARWIEERQGSGQEIPVDDVCASLAGSVAQVLSRKSMRGCEQFDSTTLIVGGGFSANSQLREALMEVGCNHGVDVRIPQIKLCTDNGAMVAMLGSNLVEAGVAPSDMEFPIDSAMPLTKICM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUA2</accession>
    <name>B8DUA2_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">def</name>
        <name evidence="3" type="ordered locus">BLA_1294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218014.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1294"/>
    <dbReference type="EnsemblBacteria" id="ACL29581">
        <property type="protein sequence ID" value="ACL29581"/>
        <property type="gene ID" value="BLA_1294"/>
    </dbReference>
    <dbReference type="GeneID" id="66533120"/>
    <dbReference type="KEGG" id="bla:BLA_1294"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1356"/>
    <dbReference type="HOGENOM" id="CLU_061901_1_2_11"/>
    <dbReference type="OMA" id="RAFSYNV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="160" mass="18109" checksum="E337D23BACA56E48" modified="2009-03-03" version="1">MAIREIRVVPDPVLRTPCDPITEITPAVRNLVQDLLDTVDDPGRAGVSANQIGVSLRAFSYNIDGKIGYVLNPVLEETRGEQYGDEGCLSLPKLWYKTKRADYARVRGMDLDGNEIVLEGDGIMGRMLQHETDHLDGHLYIDRLEKDERRAAMRRMRSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUA7</accession>
    <name>B8DUA7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable phosphatidate cytidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cdsA</name>
        <name evidence="2" type="ordered locus">BLA_1299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218006.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1299"/>
    <dbReference type="EnsemblBacteria" id="ACL29586">
        <property type="protein sequence ID" value="ACL29586"/>
        <property type="gene ID" value="BLA_1299"/>
    </dbReference>
    <dbReference type="GeneID" id="66533125"/>
    <dbReference type="KEGG" id="bla:BLA_1299"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1361"/>
    <dbReference type="HOGENOM" id="CLU_037294_0_0_11"/>
    <dbReference type="OMA" id="FGKHPMA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="322" mass="35317" checksum="8F4B410815E352CB" modified="2009-03-03" version="1">MDSQMQRDREAKADEAINAINRKAGRNMPQAVGTAIALIAIILLCLWASPILFVVLVVLFMIAGLWELRVDFATINLHIPLVTLWICSTVTLLAVYFYPRHVVAMAVCVAVSLIAVAFSATLQVWHGRRVEKELDNKALTTPDAPDRRTEQHSHLTQVAVAMFTVLYIPLLASCIVMPLTFNEHYFAHAMLIVFMPALSDTGGLFAGMLFGRHKLSPRISPKKSVEGLCGSMLFAVAGAYAVFACTYEPALWATRWWAPLLTGVIIGIVGTYGDLCASMLKRDMGIKDMGHMLKGHGGVLDRVDSILMCAPFICVLLWATGL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUC3</accession>
    <name>HIS1_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP phosphoribosyltransferase</fullName>
            <shortName evidence="1">ATP-PRT</shortName>
            <shortName evidence="1">ATP-PRTase</shortName>
            <ecNumber evidence="1">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisG</name>
        <name type="ordered locus">BLA_1315</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Feedback inhibited by histidine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP phosphoribosyltransferase family. Long subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217986.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DUC3"/>
    <dbReference type="SMR" id="B8DUC3"/>
    <dbReference type="STRING" id="442563.BLA_1315"/>
    <dbReference type="EnsemblBacteria" id="ACL29602">
        <property type="protein sequence ID" value="ACL29602"/>
        <property type="gene ID" value="BLA_1315"/>
    </dbReference>
    <dbReference type="GeneID" id="66533140"/>
    <dbReference type="KEGG" id="bla:BLA_1315"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1377"/>
    <dbReference type="HOGENOM" id="CLU_038115_1_1_11"/>
    <dbReference type="OMA" id="YVMMDYD"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP_PRibTrfase_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000118243" description="ATP phosphoribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00079"/>
        </source>
    </evidence>
    <sequence length="283" mass="31023" checksum="EF8481C273C5285B" modified="2009-03-03" version="1">MLRIAVPNKGMLSEPAWAMLSEAGYTLRSNPRQLVVEDPDNDVELFYLRPLDIAVYVGMGTIDVGITGHDLLLNSGTDAQEEMNLGFGGSTFRFAAPQDSPITTLDDVEGKRVGTSFDKLVHDYLTEHGINATPIHLDGAVESSVQLGVADLIADVVSTGTTLRNAGLRIFGEPILHSEAVLIRSPRLDPQDERLERLERRLHGVLTAKRYVLMDFDIPVEKISAAVQITPGFESPTISPLHDKQWAAVRVMVPKAKVNQLMDQLYEVGARGIIVTAIQATRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUD2</accession>
    <name>B8DUD2_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">crcB</name>
        <name evidence="10" type="ordered locus">BLA_1324</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217976.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29611">
        <property type="protein sequence ID" value="ACL29611"/>
        <property type="gene ID" value="BLA_1324"/>
    </dbReference>
    <dbReference type="GeneID" id="66533149"/>
    <dbReference type="KEGG" id="bla:BLA_1324"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1386"/>
    <dbReference type="HOGENOM" id="CLU_114342_3_3_11"/>
    <dbReference type="OMA" id="TWMLETH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00494">
        <property type="entry name" value="crcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL29611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="125" mass="13688" checksum="4CF3E1D302ED8152" modified="2009-03-03" version="1">MELIAVGFGCALGAVCRYLLENGFNNWTMDPISILVINCVGCFLMGLFTAIIERREPSKAMAKFMTTGFCGGLTTFSTFSADTYKLLQTNAWQAIALVLASLFLGMLLYALGHRLPRRNAHADVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUD4</accession>
    <name>B8DUD4_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA polymerase-binding protein RbpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbpA</name>
        <name evidence="2" type="ordered locus">BLA_1326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Bind 1 Zn(2+) per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with the RNAP catalytic core and with free principal sigma factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase-binding protein RbpA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217973.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1326"/>
    <dbReference type="EnsemblBacteria" id="ACL29613">
        <property type="protein sequence ID" value="ACL29613"/>
        <property type="gene ID" value="BLA_1326"/>
    </dbReference>
    <dbReference type="GeneID" id="66533151"/>
    <dbReference type="KEGG" id="bla:BLA_1326"/>
    <dbReference type="HOGENOM" id="CLU_134276_0_0_11"/>
    <dbReference type="OMA" id="VWECRCG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001000">
        <property type="term" value="F:bacterial-type RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01483">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038638">
        <property type="entry name" value="RbpA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025182">
        <property type="entry name" value="RNApol-bd_RbpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13397">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="115" mass="13284" checksum="7EBC8CB487E19314" modified="2009-03-03" version="1">MAERSLRGMSIGAKSLESDDNVDFAARVEVAYVCPKGHRTILPFAESADLPNEWECRCGATAHRENEEDEQPDEITKPTRTHWDMLMERRSEDELAALLEKRLKMHHDGWIPDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUL5</accession>
    <name>B8DUL5_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Heme chaperone HemW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hemN</name>
        <name evidence="11" type="ordered locus">BLA_1409</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1409"/>
    <dbReference type="EnsemblBacteria" id="ACL29694">
        <property type="protein sequence ID" value="ACL29694"/>
        <property type="gene ID" value="BLA_1409"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1409"/>
    <dbReference type="HOGENOM" id="CLU_027579_1_0_11"/>
    <dbReference type="OMA" id="HIPWCVR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010723">
        <property type="entry name" value="HemN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06969">
        <property type="entry name" value="HemN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00562">
        <property type="entry name" value="HemN-like__clustered_with_heat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL29694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="420" mass="46474" checksum="F3FCD91FBF56C856" modified="2009-03-03" version="1">MPFEVYVHVPFCIRRCGYCDFNTYTALDLGEGASRANYATLAIREMRVVHEWQLAHGVVEPPASTVFFGGGTPTLLPAGDLVAMLDAVREIWGIREDAEITTEANPDSVDPGYLRLLRDGGFTRISFGMQSSVPHVLRTLDRTHNPSNVAADVEAAHRLGLETSVDLIYGAPGESIEDWCDSVRSAIDLGVHHISAYALTVEPHTKMGRRIAAGEIEAPDDDDEATKYELADQLLSAAGLEWYEISNWARPGHESRHNLGYWRNVDWAGIGPGAHSHYNAVRRMDMGIGHDPKAGIPVGANGQGYPARDTWTSMRAWDIPHPRVWAVALQHNRVPWQDFELIDCDENAEELLMLGVRLREGLNVSAFAERTGMKIPSTAIDTLVNEGLLTRSDDALIATLRGRLLNDLVIERLMDAAFHH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUL7</accession>
    <name>RS20_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsT</name>
        <name type="ordered locus">BLA_1411</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds directly to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217863.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DUL7"/>
    <dbReference type="SMR" id="B8DUL7"/>
    <dbReference type="STRING" id="442563.BLA_1411"/>
    <dbReference type="EnsemblBacteria" id="ACL29696">
        <property type="protein sequence ID" value="ACL29696"/>
        <property type="gene ID" value="BLA_1411"/>
    </dbReference>
    <dbReference type="GeneID" id="66533240"/>
    <dbReference type="KEGG" id="bla:BLA_1411"/>
    <dbReference type="HOGENOM" id="CLU_160655_0_1_11"/>
    <dbReference type="OMA" id="GVIHKNA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00500">
        <property type="entry name" value="Ribosomal_S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002583">
        <property type="entry name" value="Ribosomal_S20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036510">
        <property type="entry name" value="Ribosomal_S20_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33398">
        <property type="entry name" value="PTHR33398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01649">
        <property type="entry name" value="Ribosomal_S20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46992">
        <property type="entry name" value="SSF46992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00029">
        <property type="entry name" value="S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000135774" description="30S ribosomal protein S20">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="86" mass="9247" checksum="24972CF8A2607640" modified="2009-03-03" version="1">MANIKSQKKRVRTNEKAHQRNVAVKSALKTYIRRTREAIASGDKAAAEAAFAIAGRKLDQAAGKGVIAKNQAANRKSSLALQINAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUL9</accession>
    <name>B8DUL9_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Branched-chain-amino-acid transaminase</fullName>
            <ecNumber evidence="9">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ilvE</name>
        <name evidence="14" type="ordered locus">BLA_1413</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="9"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217861.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1413"/>
    <dbReference type="EnsemblBacteria" id="ACL29698">
        <property type="protein sequence ID" value="ACL29698"/>
        <property type="gene ID" value="BLA_1413"/>
    </dbReference>
    <dbReference type="GeneID" id="66533242"/>
    <dbReference type="KEGG" id="bla:BLA_1413"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1477"/>
    <dbReference type="HOGENOM" id="CLU_031922_0_2_11"/>
    <dbReference type="OMA" id="LTEVFAC"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="PTHR11825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACL29698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="375" mass="41548" checksum="D25BE51783EF713A" modified="2009-03-03" version="1">MTNDSHHNPEALDKLAEDWTVLPNPNPASDAKREELIDRPAFGQVFSDSMAHMTWTKGEGWNDRRIEPYAPLKMDPGASVLHYAQECFEGLKAYRHADGSTWLFRPDCNAERLQNSAKRLYLPEVPIDDFLGSCAALVEQDVKWVPSRREYTLYLRPFIFASEAFLGVRAPEEVEYCVIASPSGPYFPGGVKPVSIWVEDKWFRTGPGGTGFAKCGGNYAASLLGEYRGISEGCEQVCFVDAATKTYLEELGGMNMMVVYKDGHVETPSLTGNILPGVTRRSIIQLLEDDGHDVVETMIALDQLLDDIKSGKVTEVFACGTAAIVTPIGRFKSEKFDVTVGDGEPGELTMAIRNQLLGIQLGEIADPHDWMWKVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUM0</accession>
    <name>B8DUM0_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General stress protein CTC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplY</name>
        <name evidence="6" type="synonym">ctc</name>
        <name evidence="9" type="ordered locus">BLA_1414</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217860.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1414"/>
    <dbReference type="EnsemblBacteria" id="ACL29699">
        <property type="protein sequence ID" value="ACL29699"/>
        <property type="gene ID" value="BLA_1414"/>
    </dbReference>
    <dbReference type="GeneID" id="66533243"/>
    <dbReference type="KEGG" id="bla:BLA_1414"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1478"/>
    <dbReference type="HOGENOM" id="CLU_075939_1_0_11"/>
    <dbReference type="OMA" id="HVDFYEV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01334">
        <property type="entry name" value="Ribosomal_L25_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_TL5_C" evidence="8">
        <location>
            <begin position="100"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="179"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL29699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="208" mass="22616" checksum="80374229BACFE4DB" modified="2009-03-03" version="1">MANNSIVLEGELRTEFGKGPARRMRVAKEIPATIYAGGDQPVYVKLPMRETSLALRHTNALFTIKFGADSKLAVVKDVQRNPVKRIIEHIDFYEVKAGEKIEVEVPVFVEGTPKGGAIAVVDAQELKVRADVSNLPERIVVSVEGLQDGDNIFARDLELPEGVELDIADPEESVVTIEIPQEDPADFETAEPADAVPAEDEKDAGAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUN1</accession>
    <name>B8DUN1_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="6">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BLA_1425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="6"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217847.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1425"/>
    <dbReference type="EnsemblBacteria" id="ACL29710">
        <property type="protein sequence ID" value="ACL29710"/>
        <property type="gene ID" value="BLA_1425"/>
    </dbReference>
    <dbReference type="GeneID" id="66533254"/>
    <dbReference type="KEGG" id="bla:BLA_1425"/>
    <dbReference type="HOGENOM" id="CLU_067442_2_0_11"/>
    <dbReference type="OMA" id="TQWKGER"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="265" mass="28965" checksum="4FCD57AA59C674DA" modified="2009-03-03" version="1">MTDAMFVVDTTSDDAPLSSDELQTGWTLRLPEEVRRHAIGSMRLKEGDELQLSDGTGLRIQAVVDDPKSGIVRVLGFTKEERPVVRLGLIQALAKNGHDEQAIDMATQIGVDEVTPWQADRSIARFKAGRTDRKWMQTLRAATEQSRRAFIPELHGMATSKQVLAMIRRDMVHGNLVIVLHQDANATWSDVERQVEELAAKCLDDGKERTVSVVVGPEGGISDQEVEVFAEAGALVCVLGRNILRASAAGPVALGLLSRAIGRYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUP1</accession>
    <name>B8DUP1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ErfK/YbiS/YcfS/YnhG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_1435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1435"/>
    <dbReference type="EnsemblBacteria" id="ACL29720">
        <property type="protein sequence ID" value="ACL29720"/>
        <property type="gene ID" value="BLA_1435"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1435"/>
    <dbReference type="HOGENOM" id="CLU_497543_0_0_11"/>
    <dbReference type="OMA" id="MNNISHG"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022029">
        <property type="entry name" value="PG-bd_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12229">
        <property type="entry name" value="PG_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_4" evidence="5">
        <location>
            <begin position="81"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="4">
        <location>
            <begin position="355"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="499" mass="53229" checksum="F3644A811D86A40F" modified="2009-03-03" version="1">MNGPAAGKRHHVWPWIVLALVVVLAGACAGLVAFFNTRALPGTTLWGVDVSGKTQQQIAQAISNEVDGTKIPVSYEGKTGSVTLADLGVKVDAQQIAQEAVDAKRHENVFARYAPWAKHDVNPAIDAKDANPEALDEQLGTNSVKPVDAKLQVGDDGSTIAVIEGTEGHGADPTETANEAVRVVQSLGAQEPKTVEVQLKTISPAITTDEANKAKSTLDKLMAQKPGVYIGKERFAAFTPSMILAATTIDPNGNGTLPQGQIRNGNVVYDATALQKAYDEQIKPNIKSTKEDREVIVNNNGTEIEVIKEGHDGVTLDDGADANIGTKAIDAFGKGNGTVSVSGKLDPMKVKETKRHVVVDLSDHTVTALENGNAVKTMHMSAGQGNDYATGKCQASGDMCTPEGDFEIWLKYPSQNMSGTLTLSDGKKETWDVKNVGFVNYFSKSGCAIHRIATQTPYTDAQIQALGENTSHGCVGIGWDMAEWFYNWCVDGTSVHVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUP3</accession>
    <name>B8DUP3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amylopullulanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">apuB</name>
        <name evidence="3" type="ordered locus">BLA_1437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217833.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1437"/>
    <dbReference type="EnsemblBacteria" id="ACL29722">
        <property type="protein sequence ID" value="ACL29722"/>
        <property type="gene ID" value="BLA_1437"/>
    </dbReference>
    <dbReference type="GeneID" id="66533267"/>
    <dbReference type="KEGG" id="bla:BLA_1437"/>
    <dbReference type="HOGENOM" id="CLU_1599514_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="182" mass="18264" checksum="B63567EC834E4820" modified="2009-03-03" version="1">MNYVVVLNHNDQPTDLNGVTAGKYGVLVSNGKTYLHPAVSDTTAAAAVAAPADTGKDVSKAGSTVQIAGGDAIAVPARSALLLGPTAVMSEPDNPDNPNNPDNPDNSDQPDKPSGDNAHNGANNAANGANNASASHGGTASTGSSIAVIIAMVIVLLIAGSGMLLRIHSPHERTLNRQETSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUR1</accession>
    <name>B8DUR1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217811.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29740">
        <property type="protein sequence ID" value="ACL29740"/>
        <property type="gene ID" value="BLA_1457"/>
    </dbReference>
    <dbReference type="GeneID" id="66533287"/>
    <dbReference type="KEGG" id="bla:BLA_1457"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1524"/>
    <dbReference type="HOGENOM" id="CLU_120441_0_1_11"/>
    <dbReference type="OMA" id="NALMFWA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007165">
        <property type="entry name" value="Phage_holin_4_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37309">
        <property type="entry name" value="PTHR37309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04020">
        <property type="entry name" value="Phage_holin_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="121" mass="12958" checksum="803896B141CFD96C" modified="2009-03-03" version="1">MGNFLIRWFILTIAAAVMVVLLPGMHVVGHPPILGIAAFSLFMALFNASLKPVVQMLALPFSVLTFGLLALVINWLFMELASWLAINLFDVGVTIGGFWWAVLGSLIMSLVSGIVSAAVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUT0</accession>
    <name>B8DUT0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014482940.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1477"/>
    <dbReference type="EnsemblBacteria" id="ACL29759">
        <property type="protein sequence ID" value="ACL29759"/>
        <property type="gene ID" value="BLA_1477"/>
    </dbReference>
    <dbReference type="GeneID" id="66533307"/>
    <dbReference type="KEGG" id="bla:BLA_1477"/>
    <dbReference type="HOGENOM" id="CLU_013985_34_5_11"/>
    <dbReference type="OMA" id="CSKIMLL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="128" mass="14443" checksum="AFFB613E895C3F94" modified="2009-03-03" version="1">MRHTGHHGERTAWWGRNLQKWIPVSSILRRLIVCEREGTIVSSCVCVIIPNLTRGVRPYAFVENVVTRADARGHGYATACLNHAKALAQQAGCYKMMLLTGSHDPKTLDFYRHAGYSSTDKTAFIQWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUU0</accession>
    <name>B8DUU0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217762.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1487"/>
    <dbReference type="EnsemblBacteria" id="ACL29769">
        <property type="protein sequence ID" value="ACL29769"/>
        <property type="gene ID" value="BLA_1487"/>
    </dbReference>
    <dbReference type="GeneID" id="66533318"/>
    <dbReference type="KEGG" id="bla:BLA_1487"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1556"/>
    <dbReference type="HOGENOM" id="CLU_713395_0_0_11"/>
    <dbReference type="OMA" id="PYWYNNN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="409" mass="45474" checksum="0899339D8EADCFC6" modified="2009-03-03" version="1">MGRHQRAEASGLISFVICAIIGGFGMYWYMQAASAFWQISQRRFMVCAGIVAACGVASFIAGYLRRRSYNTFRGIWMFHLRRIFEVLALSIVYASTLFLTSYMLFNVMNGAMGKTVFSTYIPAICAAFAGVSGYLTFVQAELMDAKTLASLLPFFIISGVCTASFTTNDPYWFNNNFSQLGDRTTFAARMFNSTLILGGICIIIISYFAVSELIATYRVRGPHGTVHMRNPHFSYHVPKFRARIIALSILLVLCGVCFIGIGCFRYTPHPILHNVFARGMPCVMFVMLIGLPWLAPQLSRSFFVISDLALVVCAVEGVMWLKGHNTLTNVEALAAMLFLGWFIVFSRQIASIEADRIQQQLLLRQTVSLDELDANEVLDDAAETEFQTVLDEDPGIVGNDSKGVPAQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUV0</accession>
    <name>B8DUV0_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dephospho-CoA kinase</fullName>
            <ecNumber evidence="1">2.7.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephosphocoenzyme A kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">coaE</name>
        <name evidence="2" type="ordered locus">BLA_1497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3'-dephospho-CoA + ATP = ADP + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18245"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoaE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.24" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217748.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1497"/>
    <dbReference type="EnsemblBacteria" id="ACL29779">
        <property type="protein sequence ID" value="ACL29779"/>
        <property type="gene ID" value="BLA_1497"/>
    </dbReference>
    <dbReference type="GeneID" id="66533329"/>
    <dbReference type="KEGG" id="bla:BLA_1497"/>
    <dbReference type="HOGENOM" id="CLU_057180_1_1_11"/>
    <dbReference type="OMA" id="QMDIEQK"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00152">
        <property type="entry name" value="TIGR00152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="19"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="213" mass="23549" checksum="0EDDF846B6D94A4C" modified="2009-03-03" version="1">MQTVNGWRCMRIALTGGIAAGKSTVATRMAEDGADVIDYDHLAHILQEPCSPAIDPLVKAFGPGILNGRGGVDRRILSRHVFGEGAPDNATETLNGIMHPLVYELARNRERSLVGDGRKHVIVHDIPLLGEVMDTIPFVFDAIACVMAPEDLRVRRLVETRGMTEEQAHIRVYVQGDEASRLRYADVVIDATQPIEQTFEYVDSLVGQWFAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUW5</accession>
    <name>B8DUW5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Na+/xyloside symporter related transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218949.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1512"/>
    <dbReference type="EnsemblBacteria" id="ACL29794">
        <property type="protein sequence ID" value="ACL29794"/>
        <property type="gene ID" value="BLA_1512"/>
    </dbReference>
    <dbReference type="GeneID" id="66533909"/>
    <dbReference type="KEGG" id="bla:BLA_1512"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1583"/>
    <dbReference type="HOGENOM" id="CLU_027408_0_0_11"/>
    <dbReference type="OMA" id="GLYTAWM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001927">
        <property type="entry name" value="Na/Gal_symport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="PTHR11328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00792">
        <property type="entry name" value="gph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="428"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="481" mass="52165" checksum="7099651F2E59ADA7" modified="2009-03-03" version="1">MSDTVSNNASPATEVTKEAGRVKLPFKEMVSYSFTDMAGNLLYVTLSSYIMYFYTDVFGISASGALGAATILLVARFADAISAVVWGSIVDHTRTKWGQCRPWFLWLAVPFAVTVFIAFTAPSLPNETSKFWYALVTYVLAAGAVYTGIQTPITAILPNLTSDPVERNNANSFRMLGGNIGSFITSAFTIPLVGFFGTMLGGGDRSGFMAVTALYGVIAIVLLVLAFRNLRERNYHPEVQKPIPFKDSLRAAKGNWPWVILVTAFVIYWIAQSTRNGMAVYYAKYNLGNENLTSLFNGVQVIGIVGTIAMPILANKLKNKTLTMIIGLAIGAIGQLLMPLAGSNVPLALTFWTIGVIGAAIACGMPFGMLADTVDYGEWKTGIHAAGFLTAVGSAFCIQVGSGFGAFLPLQIMNANGYVANAQQSQQALNAISFCFIWLPVIVYAIVAAIMCFYRKYEKMEPMIKEEIAVRRAREVEEVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUY9</accession>
    <name>B8DUY9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DSBA oxidoreductase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_1536</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218987.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1536"/>
    <dbReference type="EnsemblBacteria" id="ACL29818">
        <property type="protein sequence ID" value="ACL29818"/>
        <property type="gene ID" value="BLA_1536"/>
    </dbReference>
    <dbReference type="GeneID" id="66533933"/>
    <dbReference type="KEGG" id="bla:BLA_1536"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1614"/>
    <dbReference type="HOGENOM" id="CLU_000288_47_3_11"/>
    <dbReference type="OMA" id="FAVYKAM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="3">
        <location>
            <begin position="117"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="345" mass="37965" checksum="73F6C0C430313303" modified="2009-03-03" version="1">MAANSKQPKRESRAQRRQEEQARVQAKRERLQKERRTQTIIGIVVTVVLIALIAIAGIAVYRNTHPSAARQQEAANEQSAAQATLKDSKVKPAKASELGGLLMSKNGYNKPVEGVPTVGIYMDFMCPGCGNLNRNLDQDLVKMMDAGQINIDLHIMSFMDRYSWINGDSNNVDDYSSRTANAAIYVAEHDDDPNHLLNFITNLYAKDFQPEEGSGYKQVTDDQIKVRMDGTGISKDVQGKAMQRGYDKWLDAVNTYTPTRSELFNRSGQLKGSMSTPTMTINGYYWDMNSSEVTSHKTLAEAFLEAIGLAQNKVGDAEVRPSIGATGKPLIGYADDNAGAATNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV01</accession>
    <name>B8DV01_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA small subunit methyltransferase G</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">16S rRNA 7-methylguanosine methyltransferase</fullName>
            <shortName evidence="2">16S rRNA m7G methyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gidB</name>
        <name evidence="2" type="synonym">rsmG</name>
        <name evidence="3" type="ordered locus">BLA_1548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the N7 position of a guanine in 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1548"/>
    <dbReference type="EnsemblBacteria" id="ACL29830">
        <property type="protein sequence ID" value="ACL29830"/>
        <property type="gene ID" value="BLA_1548"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1548"/>
    <dbReference type="HOGENOM" id="CLU_065341_5_0_11"/>
    <dbReference type="OMA" id="WDRHVLN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00074">
        <property type="entry name" value="16SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003682">
        <property type="entry name" value="rRNA_ssu_MeTfrase_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760">
        <property type="entry name" value="PTHR31760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02527">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003078">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00138">
        <property type="entry name" value="rsmG_gidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="130"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="243" mass="26386" checksum="007BBB56DE696FBC" modified="2009-03-03" version="1">MSDEQIEQSGILETIFGDALPKVRAFYEKLKSEGEPRGLIGPRDVDILWERHLLNSAAVVPFIRQATSGKQFRSVADIGSGGGFPGLVAAAMLPDHTFTLIEPMERRCEWLSECVETMGLENVQIVRARSEEAIAALEQARGKSSGRGHAKNTVTPEVAQAIRHPFTVVTCRAVAPMTKLTGWTLPLVAPHGELIALKGRSAGAEIEKARKVIAQYGGRHARVKEAEVAPGLEPTHVLIVDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV02</accession>
    <name>B8DV02_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Single-stranded nucleic acid binding R3H domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_1549</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219008.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1549"/>
    <dbReference type="EnsemblBacteria" id="ACL29831">
        <property type="protein sequence ID" value="ACL29831"/>
        <property type="gene ID" value="BLA_1549"/>
    </dbReference>
    <dbReference type="GeneID" id="66533947"/>
    <dbReference type="KEGG" id="bla:BLA_1549"/>
    <dbReference type="HOGENOM" id="CLU_042512_3_0_11"/>
    <dbReference type="OMA" id="MLDIASW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02414">
        <property type="entry name" value="jag_KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02644">
        <property type="entry name" value="R3H_jag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038008">
        <property type="entry name" value="Jag_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039247">
        <property type="entry name" value="KhpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034079">
        <property type="entry name" value="R3H_KhpB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35800">
        <property type="entry name" value="PTHR35800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="SSF82708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="3">
        <location>
            <begin position="98"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="180" mass="20359" checksum="9524DB133DBD4EEC" modified="2009-03-03" version="1">MVQTDDKTLDQLNEEADIAADYLEGLLDIADYEGDIEMGVRNGRPMVQIVADDDTDIKHLIGKNGEVVDALQQLTRLAVQQATGERSHLIVDVDGFLKRKRQTLRDMALDAVDEVRETGEPVDLKPMNSFERKIIHDVVRDEGLRSRSHGEEPHRYVTVYLKRAEADGEAVEEDEFLVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV18</accession>
    <name>B8DV18_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CP_ATPgrasp_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0014"/>
    <dbReference type="EnsemblBacteria" id="ACL28319">
        <property type="protein sequence ID" value="ACL28319"/>
        <property type="gene ID" value="BLA_0014"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0014"/>
    <dbReference type="HOGENOM" id="CLU_2421051_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007302">
        <property type="entry name" value="CP_ATPgrasp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04174">
        <property type="entry name" value="CP_ATPgrasp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP_ATPgrasp_1" evidence="1">
        <location>
            <begin position="24"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="98" mass="11176" checksum="8F5650F7631481AB" modified="2009-03-03" version="1">MKRATVAMICGLLCGSFRKICRGEDNLRIPSGASSPLFECDIERRTTPRLFRDVRVRYKTVFFLIMVGLLCGDAVIDHTAENYGRLLTQMYGNRPYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV25</accession>
    <name>B8DV25_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219051.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28326">
        <property type="protein sequence ID" value="ACL28326"/>
        <property type="gene ID" value="BLA_0021"/>
    </dbReference>
    <dbReference type="GeneID" id="66532396"/>
    <dbReference type="KEGG" id="bla:BLA_0021"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.22"/>
    <dbReference type="HOGENOM" id="CLU_914200_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="304" mass="33932" checksum="BEB3A15B036D204A" modified="2009-03-03" version="1">MAEYSGSSGYAEYEYLGTANGTSFAKRHPYLLWQIIGWSILLADAVFFVVAALQDFGEWCYPVIVFPFIAALFAVIGSPFLIYFSRKAKIPQAASKREASVVRSHITMISQIRGESHPVLMALLIIALALGLLVLTLQLGMRGYILPGFLAMVAMVVVPFVVYAQYSAAQRKRFMAVPDAAYLVGVHYADQSRYESVELRETDALMMPVPAKPSTAMLDFVYNWLREYLATDWLTVTVLSFDDLLRSGVVVNDSDTEDTDPTASFPLIPARQFNLDGDARAQLDEESKAIGAFWLSRWRGYTQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV33</accession>
    <name>B8DV33_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RE_EcoO109I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619608.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28334">
        <property type="protein sequence ID" value="ACL28334"/>
        <property type="gene ID" value="BLA_0029"/>
    </dbReference>
    <dbReference type="GeneID" id="66532406"/>
    <dbReference type="KEGG" id="bla:BLA_0029"/>
    <dbReference type="HOGENOM" id="CLU_1010601_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032793">
        <property type="entry name" value="RE_EcoO109IR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14511">
        <property type="entry name" value="RE_EcoO109I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RE_EcoO109I" evidence="2">
        <location>
            <begin position="89"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="317" mass="36218" checksum="A380867FFA24870A" modified="2009-03-03" version="1">MKYAFQPEILRQTLHSLIKICICRIRTLRLIHMEDQVRIYDSAAEEEARRESARSILNAYIQSRIAFYDGTGSSSMTYERLLGKDFAIYALRGIETAEDYAREAFHAVESSSEETAMGTRWQELIASIAENAIDTGDLTATRDGAVYVIELKSQENTTNSSSFPNELRSLRQRMKEITGRKRASNQRVEAAICITRSTISKDEWRTFEVSGVTQENADLKNFRYRYLSGTAMWQWLCGIDSPYGLIRPFSSINSEAVLLARESSLERVTTQLLEELDKNGLPHTLDGVAELSDRYKAEKEAKRREREAKRNARNTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV47</accession>
    <name>B8DV47_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multidrug-efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BLA_0045</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619616.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0045"/>
    <dbReference type="EnsemblBacteria" id="ACL28348">
        <property type="protein sequence ID" value="ACL28348"/>
        <property type="gene ID" value="BLA_0045"/>
    </dbReference>
    <dbReference type="GeneID" id="66532421"/>
    <dbReference type="KEGG" id="bla:BLA_0045"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.49"/>
    <dbReference type="HOGENOM" id="CLU_040011_0_0_11"/>
    <dbReference type="OMA" id="PMVVDMT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="19"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL28348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="419" mass="44297" checksum="7A60DEF5AC2C79A3" modified="2009-03-03" version="1">MSTVSLEQTSSALSRSDRIRLLASFLVFPLLWCSGLFMVAAVLLPQRLRDVMGADAATAAFGVINACTAFISLLSNLVVGNLSDHTRSRFGRRTPWVISGGIVGGVSLALVGFLDNVWLIGISYCVCMIGLNMMIAPVIATLSDRVPANMRGTMSAFLAGGTAVGSALGQMLGSRFLSNQIPGFLLSGTLMGLAGICTVLVWPKEPSSKHLAKTSNGFGDMLKSFIPPTKGARDFWLAFVGRSLFIFAYYMILNYQLYVLEDYVGQSAQQAGNTIAVMSMVSMIVGLVSSLAGGPISDRIGKRKIMIVLASVLMAVGFVLPWILHSPLSMILFAGFSGFGYGLYGAVDQALNVDVLPNKEEAGKDLGILNIATTLGQMVGPIVTSAVVAATGGYTVVFPVAIGFAAFASLFIMLIKSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV72</accession>
    <name>B8DV72_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N6-adenine-specific methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0070"/>
    <dbReference type="EnsemblBacteria" id="ACL28373">
        <property type="protein sequence ID" value="ACL28373"/>
        <property type="gene ID" value="BLA_0070"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0070"/>
    <dbReference type="HOGENOM" id="CLU_038123_0_0_11"/>
    <dbReference type="OMA" id="LCRADAL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041497">
        <property type="entry name" value="Thump-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18096">
        <property type="entry name" value="Thump_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thump_like" evidence="1">
        <location>
            <begin position="348"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="420" mass="45994" checksum="07E1F0F6864F7F47" modified="2009-03-03" version="1">MANGCGTGSLVGMANLQMSQETREFIRAHAGEDVRELALHTKRDVPGLDLPFALDQIAGREIARTKLPQWAACEGIVYPPHLAMEQCSSQFTAEYKAQVAAQLVEEESEPTLVDLTGGFGVDFSAMVRGFAHGTYVERQERLCEVARHNLRELGLGGRADVVCGDGVDHLAQMPPATLIYLDPARRDEHGARTYAIEDCTPNALALRGQLLDKAPFVMIKLSPMLDWRKTIADFVGSVAQVHITATGNECKEIVVVLARGEHERVRVVCVNDAQRLEFEVGADSAGSWQRADVLDACELGAQRYLYEPNAAIMKAGAFGEITRNYDVRQIGANSHLFVSEHPVADFPGRAFEITALGTMNKRDVRQVLGGISAANVSVRNFPLTVQQLRRKLKLRDGGDVYLFATTVAGGHMLLRTRKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV81</accession>
    <name>B8DV81_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Possible phosphoprotein phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0079</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218376.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0079"/>
    <dbReference type="EnsemblBacteria" id="ACL28382">
        <property type="protein sequence ID" value="ACL28382"/>
        <property type="gene ID" value="BLA_0079"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0079"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.84"/>
    <dbReference type="HOGENOM" id="CLU_025431_1_1_11"/>
    <dbReference type="OMA" id="ITQDHTW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017018">
        <property type="term" value="F:myosin phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="517" mass="55799" checksum="4C7A88C6818AD621" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV91</accession>
    <name>B8DV91_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Probable ferredoxin/ferredoxin-NADP reductase</fullName>
            <ecNumber evidence="11">1.18.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">fprA</name>
        <name evidence="11" type="ordered locus">BLA_0089</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.2" evidence="11"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0089"/>
    <dbReference type="EnsemblBacteria" id="ACL28392">
        <property type="protein sequence ID" value="ACL28392"/>
        <property type="gene ID" value="BLA_0089"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0089"/>
    <dbReference type="HOGENOM" id="CLU_024722_4_0_11"/>
    <dbReference type="OMA" id="RFNFIGN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004324">
        <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 8" id="KW-0521">NADP</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="10">
        <location>
            <begin position="8"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="457"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="207"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="393"/>
            <end position="395"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL28392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="482" mass="53414" checksum="046524E32CEA90A1" modified="2009-03-03" version="1">MTQDSELRIAVIGAGPAGVYSSDIFLRQLAKLGDELGLGTDARIDLFEKLPVPFGLVRYGVAPDHPSIKFIASALEKTLDNPNIHLYADVEFGKDVTLEDLLERYDAILFATGAIKDKPLAIPGADLDGVYGAARFVEWYDGYPTGVREWPLEAERVAVIGGGNVAMDVARELMRNADDLRAKTDIPDNVYEGIKNNKAKELHLFIRRGVAQAKFSVQELREMEKLPGVQLIIDEDDFELDDDTVEEAGKDKLTRQMVEELFVIRDMAEDMEDDGDVDFEGNPADRKYYIHFNSAPTEILGEDGKVRGIRVERTETGADGKMHRTGEFTDYPVEAVYHAIGYKPESVPGIAYDEGGAHLANANGDGRITVDHENGEVRERLYATGWAKRGPVGLIGSTKSDALMIVTAMLEDLAQNKENARLAPDRDPESIDRLLAERGVRPIDFAGWKRVDAYERAEGAKEGREHKKVIDPDQFRALAHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVF0</accession>
    <name>B8DVF0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP binding protein of ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_0148</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0148"/>
    <dbReference type="EnsemblBacteria" id="ACL28451">
        <property type="protein sequence ID" value="ACL28451"/>
        <property type="gene ID" value="BLA_0148"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0148"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OMA" id="MGCEDID"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="243" mass="25838" checksum="B88886ED61A6C34F" modified="2009-03-03" version="1">MSSAHDFHATGVTAVVNNDAGGTRTIFKDLSFAVHGGEIVDITGPSGSGKSTLLTSFARLNVNTTGKFVLDGVDSDTLSPQQWRERVAYLPQTSVLIGDNVADAIRLPWSLKIRVSQDHEAAEQKLPDSLIRSTLDSLGCDDIDLARAVQDLSGGQAARVSLTRTLLTHPGVLLADEVDAGLDEENADKVADILRKAADNGTAVVRIRHRKPDGRANRIMVLANGTISPLKTAQSAPSTHTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVH2</accession>
    <name>B8DVH2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Periplasmic solute binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_0171</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218486.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0171"/>
    <dbReference type="EnsemblBacteria" id="ACL28473">
        <property type="protein sequence ID" value="ACL28473"/>
        <property type="gene ID" value="BLA_0171"/>
    </dbReference>
    <dbReference type="GeneID" id="66532546"/>
    <dbReference type="KEGG" id="bla:BLA_0171"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.180"/>
    <dbReference type="HOGENOM" id="CLU_016838_7_0_11"/>
    <dbReference type="OMA" id="ETWVPKV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015304">
        <property type="entry name" value="ZinT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09223">
        <property type="entry name" value="ZinT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="ZinT" evidence="4">
        <location>
            <begin position="353"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="527" mass="57290" checksum="A85563542C5DE248" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVI2</accession>
    <name>B8DVI2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218498.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0181"/>
    <dbReference type="EnsemblBacteria" id="ACL28483">
        <property type="protein sequence ID" value="ACL28483"/>
        <property type="gene ID" value="BLA_0181"/>
    </dbReference>
    <dbReference type="GeneID" id="66532557"/>
    <dbReference type="KEGG" id="bla:BLA_0181"/>
    <dbReference type="HOGENOM" id="CLU_066192_18_0_11"/>
    <dbReference type="OMA" id="MKQSAFA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="90" mass="10183" checksum="81EC99A09C18EDDA" modified="2009-03-03" version="1">MRSFNSMLDEQMDDPEFATVFEAEIERLNAAVAVSRAREEARLTQEQLAERSGVSRVTINRIERGKLNPSMKTLSRLARAMGKQVRVSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVJ3</accession>
    <name>B8DVJ3_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Polyphosphate kinase</fullName>
            <ecNumber evidence="6 7">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-polyphosphate phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Polyphosphoric acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 12" type="primary">ppk</name>
        <name evidence="12" type="ordered locus">BLA_0192</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="6 7">An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the polyphosphate kinase 1 (PPK1) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="6 7"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218510.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0192"/>
    <dbReference type="EnsemblBacteria" id="ACL28494">
        <property type="protein sequence ID" value="ACL28494"/>
        <property type="gene ID" value="BLA_0192"/>
    </dbReference>
    <dbReference type="GeneID" id="66532567"/>
    <dbReference type="KEGG" id="bla:BLA_0192"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.201"/>
    <dbReference type="HOGENOM" id="CLU_009678_5_0_11"/>
    <dbReference type="OMA" id="NIKWARK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009358">
        <property type="term" value="C:polyphosphate kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1840.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00347">
        <property type="entry name" value="Polyphosphate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003414">
        <property type="entry name" value="PP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041108">
        <property type="entry name" value="PP_kinase_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024953">
        <property type="entry name" value="PP_kinase_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036830">
        <property type="entry name" value="PP_kinase_middle_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025200">
        <property type="entry name" value="PPK_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025198">
        <property type="entry name" value="PPK_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036832">
        <property type="entry name" value="PPK_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30218">
        <property type="entry name" value="PTHR30218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02503">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13090">
        <property type="entry name" value="PP_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17941">
        <property type="entry name" value="PP_kinase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13089">
        <property type="entry name" value="PP_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015589">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140356">
        <property type="entry name" value="SSF140356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03705">
        <property type="entry name" value="poly_P_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 6 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PP_kinase_N" evidence="9">
        <location>
            <begin position="44"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase" evidence="8">
        <location>
            <begin position="159"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C_1" evidence="11">
        <location>
            <begin position="374"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C" evidence="10">
        <location>
            <begin position="547"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphohistidine intermediate" evidence="6">
        <location>
            <position position="479"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="608"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="636"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACL28494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="744" mass="83583" checksum="834244725D38E461" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVJ4</accession>
    <name>B8DVJ4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619662.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28495">
        <property type="protein sequence ID" value="ACL28495"/>
        <property type="gene ID" value="BLA_0193"/>
    </dbReference>
    <dbReference type="GeneID" id="66533955"/>
    <dbReference type="KEGG" id="bla:BLA_0193"/>
    <dbReference type="HOGENOM" id="CLU_2380414_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="94" mass="10842" checksum="3FC01AE9AF949137" modified="2009-03-03" version="1">MFNHSNTAAILRRVAHCSPKISHFHEHTKSANVPWCFVVRRAIRMAAIIQTISRAELNARRTETAARIGTAKRAHPWTYSEFFRELSDFSARSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVP4</accession>
    <name>B8DVP4_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268336.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0243"/>
    <dbReference type="EnsemblBacteria" id="ACL28545">
        <property type="protein sequence ID" value="ACL28545"/>
        <property type="gene ID" value="BLA_0243"/>
    </dbReference>
    <dbReference type="GeneID" id="66532619"/>
    <dbReference type="KEGG" id="bla:BLA_0243"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.258"/>
    <dbReference type="HOGENOM" id="CLU_017584_4_3_11"/>
    <dbReference type="OMA" id="FYVMARF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="34"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="398" mass="44022" checksum="156A6F70DF8D11FE" modified="2009-03-03" version="1">MINEKYKAMLGEKSVIRMISERAAARRAEIGADEVFDFSIGNPSVPCTPAFTNAVIDLYENEAPSALHGYSPSVGITSFRGAVADSLNRRFGMDYTEQHIFPTSGATGSLAHAFRAVTKPGDEVLTFAPFFPEYIPYVEGTGATLTVVPPDTTAFQIDFEAFERALNPNVAVVLINTPNNPSGAAYSAATLERLAGILRDKQTEYGHDIFIVSDEPYREIMFDGAAQAYPAKFYDNTLTCYSFSKSLSLPGERIGYVAVNPRATDADVLVPMFAQISRTIGHNCPSSTMQLAVERVIDDTSDLSIYEANMNLLYDALVDLGFEVVRPSGTFYIFPKALEEDANEFARKAMEYDLFMVPSDSFGMPGYLRLSYCVETEHLRKAIVRLRQFVTEVYGERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVP9</accession>
    <name>B8DVP9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">recG</name>
        <name evidence="4" type="ordered locus">BLA_0248</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268350.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0248"/>
    <dbReference type="EnsemblBacteria" id="ACL28550">
        <property type="protein sequence ID" value="ACL28550"/>
        <property type="gene ID" value="BLA_0248"/>
    </dbReference>
    <dbReference type="GeneID" id="66532624"/>
    <dbReference type="KEGG" id="bla:BLA_0248"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.263"/>
    <dbReference type="HOGENOM" id="CLU_005122_7_1_11"/>
    <dbReference type="OMA" id="DNGFQAC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045562">
        <property type="entry name" value="RecG_dom3_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19833">
        <property type="entry name" value="RecG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="342"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="568"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="790" mass="86920" checksum="5ED447BE433AA856" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVS1</accession>
    <name>B8DVS1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268388.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0270"/>
    <dbReference type="EnsemblBacteria" id="ACL28572">
        <property type="protein sequence ID" value="ACL28572"/>
        <property type="gene ID" value="BLA_0270"/>
    </dbReference>
    <dbReference type="GeneID" id="66532645"/>
    <dbReference type="KEGG" id="bla:BLA_0270"/>
    <dbReference type="HOGENOM" id="CLU_142113_1_0_11"/>
    <dbReference type="OMA" id="QTKERPD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021400">
        <property type="entry name" value="DUF3039"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11238">
        <property type="entry name" value="DUF3039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="97" mass="10936" checksum="4FEEA90D29280555" modified="2009-03-03" version="1">MSFAYNDALDDNTTAATEPSSDTGTAVLERPKAQERRADDGDADRFAHYVSRDRIAESRLTGRPVVALCGKVWVPKRNPKDYPICPECKRIYEEMTK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVT9</accession>
    <name>RL21_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplU</name>
        <name type="ordered locus">BLA_0288</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268422.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DVT9"/>
    <dbReference type="SMR" id="B8DVT9"/>
    <dbReference type="STRING" id="442563.BLA_0288"/>
    <dbReference type="EnsemblBacteria" id="ACL28590">
        <property type="protein sequence ID" value="ACL28590"/>
        <property type="gene ID" value="BLA_0288"/>
    </dbReference>
    <dbReference type="GeneID" id="66532665"/>
    <dbReference type="KEGG" id="bla:BLA_0288"/>
    <dbReference type="HOGENOM" id="CLU_061463_3_0_11"/>
    <dbReference type="OMA" id="HRQEITR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018258">
        <property type="entry name" value="Ribosomal_L21_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01169">
        <property type="entry name" value="RIBOSOMAL_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000166703" description="50S ribosomal protein L21">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <sequence length="102" mass="11044" checksum="A0674511688ACDDB" modified="2009-03-03" version="1">MYAIVKAGGHQEKVEVGDTILVNRLDAKNGETVEFPVALVVDGEKVIIAAADLAKISVKAEVVNDDAKGPKIRIQKFKNKTGVARRKGHRQKLTQLKITAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVU9</accession>
    <name>B8DVU9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biotin acetyl-CoA-carboxylase synthetase</fullName>
            <ecNumber evidence="2">6.3.4.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.4.15" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268441.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0298"/>
    <dbReference type="EnsemblBacteria" id="ACL28600">
        <property type="protein sequence ID" value="ACL28600"/>
        <property type="gene ID" value="BLA_0298"/>
    </dbReference>
    <dbReference type="GeneID" id="66532676"/>
    <dbReference type="KEGG" id="bla:BLA_0298"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.318"/>
    <dbReference type="HOGENOM" id="CLU_051096_5_1_11"/>
    <dbReference type="OMA" id="DESVNGW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="43"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="298" mass="32201" checksum="06B00AB5682FD5F4" modified="2009-03-03" version="1">MTTELNGDYRRAREKAHVISLDTVTSTNDYAAQLVADGRLDRNGMTIVLAREQTQGRGRLDHTWVSVPGKSFIASVICIVNADTAKDPQVNGWLQMIAGMSVIDALRETVMSANMDWLDHTRGNPSMRSELQLKWPNDIVYQGMKLGGILAQLVQIPGDENSVAIIFGVGLNLDLAPDQLPTAQSTSLQLIASCVNGAACVPADQLADMIAAGLVNALSKRLWYFGENPAGYAQNLHRRIAEECWTLGKPVLVHRTDGTTLTGEAVAINEDASLSVRDDSGQVHVVRTGDVGVLPVED</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVW3</accession>
    <name>NRDI_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein NrdI</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nrdI</name>
        <name type="ordered locus">BLA_0312</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably involved in ribonucleotide reductase function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NrdI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268475.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DVW3"/>
    <dbReference type="SMR" id="B8DVW3"/>
    <dbReference type="STRING" id="442563.BLA_0312"/>
    <dbReference type="EnsemblBacteria" id="ACL28614">
        <property type="protein sequence ID" value="ACL28614"/>
        <property type="gene ID" value="BLA_0312"/>
    </dbReference>
    <dbReference type="GeneID" id="66532691"/>
    <dbReference type="KEGG" id="bla:BLA_0312"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.334"/>
    <dbReference type="HOGENOM" id="CLU_114845_0_0_11"/>
    <dbReference type="OMA" id="NTHRFVG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00128">
        <property type="entry name" value="NrdI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020852">
        <property type="entry name" value="RNR_Ib_NrdI_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004465">
        <property type="entry name" value="RNR_NrdI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37297">
        <property type="entry name" value="PTHR37297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07972">
        <property type="entry name" value="Flavodoxin_NdrI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005087">
        <property type="entry name" value="NrdI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00333">
        <property type="entry name" value="nrdI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000191753" description="Protein NrdI">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00128"/>
        </source>
    </evidence>
    <sequence length="141" mass="15745" checksum="4CE91E41A926C56D" modified="2009-03-03" version="1">MSAVVYFSSASRNTERFVEHCDFPSCGVNVFRIPLQPNAAPLNVREPYIIIVPTYGGGDARKAVPPQVKRFLNDPANREWIRGVIASGNTNFGEAYAAAGPIISRKCHVPLMYRFELMGTREDVHAVREGVRRFFSDTPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVW9</accession>
    <name>B8DVW9_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyrrolidone-carboxylate peptidase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-oxoprolyl-peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Pyroglutamyl-peptidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pcp</name>
        <name evidence="9" type="ordered locus">BLA_0318</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619694.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0318"/>
    <dbReference type="EnsemblBacteria" id="ACL28620">
        <property type="protein sequence ID" value="ACL28620"/>
        <property type="gene ID" value="BLA_0318"/>
    </dbReference>
    <dbReference type="GeneID" id="66532697"/>
    <dbReference type="KEGG" id="bla:BLA_0318"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.341"/>
    <dbReference type="HOGENOM" id="CLU_043960_4_2_11"/>
    <dbReference type="OMA" id="HHIATRA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016920">
        <property type="term" value="F:pyroglutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00501">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000816">
        <property type="entry name" value="Peptidase_C15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PTHR23402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01470">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015592">
        <property type="entry name" value="Prld-crbxl_pptds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="SSF53182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL28620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="225" mass="24365" checksum="4E6020AE09D1DDC9" modified="2009-03-03" version="1">MQELSVVMSGFDPYEDVTANPALIVPDTLAEQGMGGAMDSDDDLKDVAITVHAVHMPVSFSKAWPILEAALEEHRPQIVVATGLKRASRGILLERCAINVKDTNRPDADNKVPSHHVINAAGPAAYWTGLPLNAILGAFAADEIPASLSSNAGTFVCNALFYKLQDWASRQGRTLSGFVNLPPVDEREHSQHGLTLDQQIRAGRDVIRETARYYVKPIGVNTLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVX3</accession>
    <name>B8DVX3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Predicted acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0322</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0322"/>
    <dbReference type="EnsemblBacteria" id="ACL28624">
        <property type="protein sequence ID" value="ACL28624"/>
        <property type="gene ID" value="BLA_0322"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0322"/>
    <dbReference type="HOGENOM" id="CLU_005679_11_2_11"/>
    <dbReference type="OMA" id="NRWLTNP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="6"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="625" mass="69550" checksum="CE1F799D90FDD152" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVY2</accession>
    <name>B8DVY2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Xanthine/uracil permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BLA_0331</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619696.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0331"/>
    <dbReference type="EnsemblBacteria" id="ACL28633">
        <property type="protein sequence ID" value="ACL28633"/>
        <property type="gene ID" value="BLA_0331"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0331"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.355"/>
    <dbReference type="HOGENOM" id="CLU_024508_0_1_11"/>
    <dbReference type="OMA" id="RKGSYFF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904823">
        <property type="term" value="P:purine nucleobase transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026033">
        <property type="entry name" value="Azg-like_bact_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005353">
        <property type="entry name" value="PbuG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="464" mass="48737" checksum="E95778FF8465A2A4" modified="2009-03-03" version="1">MEKFFHLKENGTSVSTEVMAGLTTFFAMSYIIVVNPQILSQTGMPWGGVFLATIIAAIIGTLVMGLFANVPYAQAPGMGLNAFFTYTVCFGLGFTWQETLAMVFLCGLINILITVTKVRKMIIKAIPEPLQQAIGGGIGLFVAYVGLLNVNFITFTPKDTKAAGQGLATGATPGMATLNSPVLWLFLIGLLLAIVFTILKVKGGLLITIIITAVIGIPMGLTTMSNSVSLGETFSQLPQTFGALFTGEGFGSLFSDPAKLPLVLVTIFAFSMSDTFDTLGTFIGTGRRTGIFSKADEESLENGHGFSSKMDKALFADSIATSIGAICGTSNTTTYVESSAGIAAGGRTGLTSVIVAACFAVSAFFAPVISAVPSAATAGVLVIVGCLMAASLKEVKWDDITEAIPAFFAAVFMAFSYSISYGIAGGFITYCIVKVCKKKANEVHPIVWIVSALFILDFICMAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVY7</accession>
    <name>B8DVY7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Superfamily I DNA and RNA helicases and helicase subunits</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619699.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0336"/>
    <dbReference type="EnsemblBacteria" id="ACL28638">
        <property type="protein sequence ID" value="ACL28638"/>
        <property type="gene ID" value="BLA_0336"/>
    </dbReference>
    <dbReference type="GeneID" id="66532715"/>
    <dbReference type="KEGG" id="bla:BLA_0336"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.361"/>
    <dbReference type="HOGENOM" id="CLU_000788_1_0_11"/>
    <dbReference type="OMA" id="LELAWWQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="1212" mass="133800" checksum="CA8576280319FFE0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVY9</accession>
    <name>B8DVY9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cation transport ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0338"/>
    <dbReference type="EnsemblBacteria" id="ACL28640">
        <property type="protein sequence ID" value="ACL28640"/>
        <property type="gene ID" value="BLA_0338"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0338"/>
    <dbReference type="HOGENOM" id="CLU_1458604_0_0_11"/>
    <dbReference type="OMA" id="GPSWTGN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08666">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867652" evidence="1">
        <location>
            <begin position="28"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="SAF" evidence="2">
        <location>
            <begin position="32"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="192" mass="20162" checksum="73314D6F1C6D75F5" modified="2009-03-03" version="1">MLWQLRHMLLALSVGVALFCTLQCVALATATRQAVVAARDLDAGLVIATGDVEMVEMPDHDALRHALGCPDDAVGLVTQTRIEKGDILLTTDVGELPQVPEHHTVIDVRLGLGQHSFPIGTVVELRSTQACADDARASPEGCVVSSHAVVMAQPRLDDTGSTVTQMAMSAVEALQVLAAQEHGTLIAARGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW02</accession>
    <name>B8DW02_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thymidylate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0351</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268552.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0351"/>
    <dbReference type="EnsemblBacteria" id="ACL28653">
        <property type="protein sequence ID" value="ACL28653"/>
        <property type="gene ID" value="BLA_0351"/>
    </dbReference>
    <dbReference type="GeneID" id="66532734"/>
    <dbReference type="KEGG" id="bla:BLA_0351"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.377"/>
    <dbReference type="HOGENOM" id="CLU_083552_1_1_11"/>
    <dbReference type="OMA" id="VTVDHQR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015269">
        <property type="entry name" value="UPF0029_Impact_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="PTHR16301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09186">
        <property type="entry name" value="DUF1949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0029" evidence="2">
        <location>
            <begin position="19"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1949" evidence="3">
        <location>
            <begin position="144"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="211" mass="23041" checksum="9717F18B0E4090BC" modified="2009-03-03" version="1">MRTLLNPADEPAHDAFVEKKSEFIGDACHVDSLEDALAFVETVRERHPKARHVAYAAIVTGDDGRVMERMSDDGEPSGTAGKPILDVLRANELTDCVIAVTRYFGGILLGSGGLIRAYSTGASIAVKAADVAQIVVCARYAVPLDYSQLGPMRHLVEVMGAVEESADFSDHVVLIVLVRDDARESFEHRVREQFSATVTPEYVGRCHRAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW03</accession>
    <name>B8DW03_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AbrB family trancriptional regulator fused to LRR containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0352"/>
    <dbReference type="EnsemblBacteria" id="ACL28654">
        <property type="protein sequence ID" value="ACL28654"/>
        <property type="gene ID" value="BLA_0352"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0352"/>
    <dbReference type="HOGENOM" id="CLU_077890_0_0_11"/>
    <dbReference type="OMA" id="TMPFPNI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="228" mass="25307" checksum="6C9EA75EE5BF8687" modified="2009-03-03" version="1">MADGEQTAQTARNTQADGVQDAAGNQGEASEAQTPQFEPLTVTYERLRHSTDPQELHEFARRPLPDRAKQAAFSRATALLEAVAGNQHTPLEDRVFLAETMPFPNVLVKLSEDPSPEVRRAVAANRDDKNWLVGRLTKDEVPEVRDEALRNPQTSWKMRMEGAQNPEVDAQTLDFLSRLGVELEPDAPRILSTMVRRGVALNPNAGAETIERLKEDPVPEVAKAAQRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW29</accession>
    <name>RL18_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplR</name>
        <name type="ordered locus">BLA_0378</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268596.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DW29"/>
    <dbReference type="SMR" id="B8DW29"/>
    <dbReference type="STRING" id="442563.BLA_0378"/>
    <dbReference type="EnsemblBacteria" id="ACL28680">
        <property type="protein sequence ID" value="ACL28680"/>
        <property type="gene ID" value="BLA_0378"/>
    </dbReference>
    <dbReference type="GeneID" id="66532761"/>
    <dbReference type="KEGG" id="bla:BLA_0378"/>
    <dbReference type="HOGENOM" id="CLU_098841_0_1_11"/>
    <dbReference type="OMA" id="NKQIYAQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_B">
        <property type="entry name" value="Ribosomal_L18_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004389">
        <property type="entry name" value="Ribosomal_L18_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="PTHR12899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00060">
        <property type="entry name" value="L18_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000166207" description="50S ribosomal protein L18">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <sequence length="123" mass="13234" checksum="8F68F4703305CB19" modified="2009-03-03" version="1">MSVKIFGKGKKAALKRRHARIRKRISGTAERPRLVVTRSNRHMVAQIVDDNAGKTLVSESTLMADFADFQGTKTEAAKKVGELLAKKAKDAGITTVVFDRGGNMYHGRVAAVAEGAREGGLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW57</accession>
    <name>B8DW57_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR-repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268659.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0406"/>
    <dbReference type="EnsemblBacteria" id="ACL28708">
        <property type="protein sequence ID" value="ACL28708"/>
        <property type="gene ID" value="BLA_0406"/>
    </dbReference>
    <dbReference type="GeneID" id="66532790"/>
    <dbReference type="KEGG" id="bla:BLA_0406"/>
    <dbReference type="HOGENOM" id="CLU_010138_1_0_11"/>
    <dbReference type="OMA" id="GYLPYYK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025117">
        <property type="entry name" value="DUF4037"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13228">
        <property type="entry name" value="DUF4037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4037" evidence="2">
        <location>
            <begin position="505"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="710" mass="77870" checksum="294D52C500E67CC1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW58</accession>
    <name>B8DW58_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator of two-component system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_0407</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268661.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0407"/>
    <dbReference type="EnsemblBacteria" id="ACL28709">
        <property type="protein sequence ID" value="ACL28709"/>
        <property type="gene ID" value="BLA_0407"/>
    </dbReference>
    <dbReference type="GeneID" id="66532791"/>
    <dbReference type="KEGG" id="bla:BLA_0407"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.435"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OMA" id="NVLRKTQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="10"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="169"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="236" mass="25200" checksum="04173634C2E88830" modified="2009-03-03" version="1">MSERERQGIRIAVVDDHEMFRAGVIATLQPYFTIVGQAADVPSAIEMIADTQPDVVLLDVHVPGGEGGGGAEILRKSQPHAPQTAFLALSVSDSAQDVGSVIRAGARGYVTKTITGNDLIHSIEQVSDGYAVFSPKLAGFVLSAFQGAPLSDGMDASNESAAGGDTVAHDAELDSLSTREQEVMRLIARGYTYKEVGAELFISVKTVETHVSNVLRKLQLSNRNELTLWAADRHIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW69</accession>
    <name>B8DW69_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminopeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pepC</name>
        <name evidence="3" type="ordered locus">BLA_0418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619715.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="MEROPS" id="C01.086"/>
    <dbReference type="EnsemblBacteria" id="ACL28720">
        <property type="protein sequence ID" value="ACL28720"/>
        <property type="gene ID" value="BLA_0418"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0418"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.446"/>
    <dbReference type="HOGENOM" id="CLU_038600_0_1_11"/>
    <dbReference type="OMA" id="DDGGWWQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00585">
        <property type="entry name" value="Peptidase_C1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004134">
        <property type="entry name" value="Peptidase_C1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363">
        <property type="entry name" value="PTHR10363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03051">
        <property type="entry name" value="Peptidase_C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005700">
        <property type="entry name" value="PepC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0788">Thiol protease</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR005700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005700-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="452" mass="52101" checksum="5F4B8C4ED7DE71FA" modified="2009-03-03" version="1">MELTKQDLSQMAEAYKKDAAQQIAEQAVKNNGIHASSEREHVVVTENNFVFSVDVDSEAVANQRQSGRCWMFSALNFLRFHMEKSLKLPKGSFQLSQNYNFFYDKLEKSNFFMENIIKYVGSDLNDRRVDFLLATPQQDGGDFDPICALIEKYGVVPLEAMPDTAVTKNTSEFNAVLNRVLREDAFKLRKLVREGKSEKEVDDARRAMLSEIYRILCVSFGEPPKTVDFEYRDTDKKYHADRGLTPLEFYKKYLGDVKLEDYVGVMNLPVEGMEYGKMYTIDMTGEVLGSKRKLHYVNVPIDVMKEATIKQLKAGEPVWFGCDVLQDSDFVKGILSLNLYDVQKMFGIKFDMDKGERFQYNQSLPTHAMTMAGVDLDADGKPIRWKVENSWGTTAHGKPVGHQGYFIMDDSWFDQYMYEVAVRKEYLPEEYQKALETEPEVLPYWNTFNPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW94</accession>
    <name>B8DW94_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Axe</fullName>
            <ecNumber evidence="3">3.1.1.72</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">axe</name>
        <name evidence="3" type="ordered locus">BLA_0444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.72" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="B8DW94"/>
    <dbReference type="ESTHER" id="bifa0-b8dw94">
        <property type="family name" value="Cutinase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28745">
        <property type="protein sequence ID" value="ACL28745"/>
        <property type="gene ID" value="BLA_0444"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0444"/>
    <dbReference type="HOGENOM" id="CLU_1040765_0_0_11"/>
    <dbReference type="OMA" id="LMGDPSH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046555">
        <property type="term" value="F:acetylxylan esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="PTHR33630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="267" mass="29277" checksum="69939EA7F29E8A0A" modified="2009-03-03" version="1">MRVITVRGTNEQLNGGMLGPLAQQIASASPGHIQVTPLEYAASVEPGTQADGVNLLMSTLNGQAEQCPAQHTVLLGYSQGAMVVGDALSAPDVRPNEDNGYTLSDRASENVIVAELFGDPRFNSETSYDVGDFTKGTNGVMGARGPHELDRYASRTQSYCNYDDPICQTYGSRKGHREYATNGLRDQAHTRRAAVNRRMRMHMRNIWRAHVRGISWNTYRCTEREPWQAMRSSARIAGNRSPSTRRATPTSCSRCGGRNSTANSNHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWB6</accession>
    <name>B8DWB6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268789.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0468"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28767">
        <property type="protein sequence ID" value="ACL28767"/>
        <property type="gene ID" value="BLA_0468"/>
    </dbReference>
    <dbReference type="GeneID" id="66532853"/>
    <dbReference type="KEGG" id="bla:BLA_0468"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.497"/>
    <dbReference type="HOGENOM" id="CLU_023978_1_0_11"/>
    <dbReference type="OMA" id="VICDNCT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="428" mass="48477" checksum="D5BA5346928CE82E" modified="2009-03-03" version="1">MAILDVLDLLLVIVGGVSIAYQGFCILVSLFAKPVTFPAAPMDKRYAVLISARNEEQVVGNLIRDIQSQSYPSKLIDIWLVADNCDDGTAQLARDLGCHVVERFNQQQVGKGYALTYLLNAMIDSKASDQYDAFFVFDADNRLDKHYFEEMNKAYQSGFRILTSYRNSVNLSENWVSSGSALWFIRESRFVSASRMWLGNSCHVGGTGFMFSQEVMRRNQGWKFHLLTEDLEFTMDSVLHGDRIGYVGSAILYDEQPVTFAQSWRQRLRWSKGFLQVFRYYGPALVRRAIQERDFSSIDLTLFICPFTVLAIIRVLLGTIFAACGFISWSSQGAALFNWMLGVVSSMVFMMVLAGLTMVVERKQIGASNRELFAYALSFPIYILSYVPISFQAVFAKAQWKPIEHQGSSGAEDPRIREQDREERAMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWD7</accession>
    <name>B8DWD7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BLA_0489</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218183.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28788">
        <property type="protein sequence ID" value="ACL28788"/>
        <property type="gene ID" value="BLA_0489"/>
    </dbReference>
    <dbReference type="GeneID" id="66533622"/>
    <dbReference type="KEGG" id="bla:BLA_0489"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.519"/>
    <dbReference type="HOGENOM" id="CLU_007946_1_2_11"/>
    <dbReference type="OMA" id="FNSDNRV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004754">
        <property type="entry name" value="Amino_acid_antiprt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00905">
        <property type="entry name" value="2A0302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL28788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="511" mass="54324" checksum="4AFB6141B3B397F3" modified="2009-03-03" version="1">MADSGQHASNAPAMVEGSGAAAAGPRSTVGFVGLFALVVSAMVGGGIFSLPQNMAQHASAGGQIVAWAITGVGMWFIVNTFRVLTHVKPHMQDGLYSYARSGFGDFVGFLVAYGYWLCNCFSLVAYGVLIMSTLDIFMPGTFTNGNNVAATIGSSLILWLMLAVALLGTKTGALINVAGTVCKIIPVIVFVVALAAVFKTGVFLRGFWGLGAQGTPLGFDVHRIGAQVSDSMLVTLWLFIGMEGAVVVSGSARHPRDVSRATTAGYLTVLVLYILVSLLPLGVYSSGQVARMPNPSMSVIMEQCFGQGGSIMVNAGVIISVVFAWLVWMIMISQMPLYAARDGIYPRSFLATNRFGAPSTGLVWTAVTCQLLLILCHFVNGDAWDVMISITSVMAMPCYLLCCVYLWKIAVREPPAFPSAAARRRALATGVLGTLFSLFLVYSAGLRYLMMACALYAIGLPLLVVARRQRRPGVPLRQLFSHRGWVVLSLIVVLGVCGLVYTVHGGVFGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWH3</accession>
    <name>B8DWH3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tmp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218236.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0525"/>
    <dbReference type="EnsemblBacteria" id="ACL28824">
        <property type="protein sequence ID" value="ACL28824"/>
        <property type="gene ID" value="BLA_0525"/>
    </dbReference>
    <dbReference type="GeneID" id="66533655"/>
    <dbReference type="KEGG" id="bla:BLA_0525"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.553"/>
    <dbReference type="HOGENOM" id="CLU_084466_1_0_11"/>
    <dbReference type="OMA" id="WDSLCAQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025503">
        <property type="entry name" value="DUF4391"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14335">
        <property type="entry name" value="DUF4391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="199"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="242" mass="26403" checksum="48F70587F047B8BE" modified="2009-03-03" version="1">MAIEAHCGTLSALTLALPRSCAVPESRGTLPKGMFVAKVAVSAKTKQHLIHAIDGITMLAILRAANTGVEQGRRIPEVLVIGLRLADGIEEAPHDIVELIQAQRKSGIVFVCVRNVEFEGAMREEACFVVRRPLSERSGHAPTFHEFASAWIPSGEALLEIADAAATTDDLWDSLCSQVIFGSTDFADLDARIVRASRIAQLRTQIAKLEGDHARAKTQERRNEAHAKLRKARAQLESLEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWH4</accession>
    <name>B8DWH4_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0526</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218238.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0526"/>
    <dbReference type="EnsemblBacteria" id="ACL28825">
        <property type="protein sequence ID" value="ACL28825"/>
        <property type="gene ID" value="BLA_0526"/>
    </dbReference>
    <dbReference type="GeneID" id="66533656"/>
    <dbReference type="KEGG" id="bla:BLA_0526"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.554"/>
    <dbReference type="HOGENOM" id="CLU_017584_4_3_11"/>
    <dbReference type="OMA" id="IHMEVGQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="48"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="409" mass="44919" checksum="8B11F14D30C41A80" modified="2009-03-03" version="1">MTGADEQTKDSQRQNMRPPFAKRAALARPFMGMRISNEAKRLRAQGVDVINLSLGQPDYGAPEPVREAMRDLYDGRPLPYSDSMGLSELREAIARFYRTAHDVEVDPKRIVITEGGSAALLLATALSVDEGDEVIIADPSYPSNRELVRSFGGKVVDVPTSAATRFHLDQPLVRQYWSERTRAVMITSPSNPTGTTIAPDVLRDVCAYAAHHGAWRIMDETYLDLTDVEADGSRVESALAVDPEAMVCGSFSKFFGMTGWRLGWMVVPEFALDAVDNLATNFFLGAHTPSQYAALACFTPQSLRICEERRQELLERRAFVVDALARIGLPLEVVPNGAFYAYFNISSTGLDAQTFCERALHEAHVALTPGGDFGPATGSTHVRLSYAASMSDLEVGFERLGDFVASLRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWI3</accession>
    <name>DAPB_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
            <shortName evidence="1">HTPA reductase</shortName>
            <ecNumber evidence="1">1.17.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dapB</name>
        <name type="ordered locus">BLA_0535</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:35323"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:35331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218250.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DWI3"/>
    <dbReference type="SMR" id="B8DWI3"/>
    <dbReference type="STRING" id="442563.BLA_0535"/>
    <dbReference type="PRIDE" id="B8DWI3"/>
    <dbReference type="EnsemblBacteria" id="ACL28834">
        <property type="protein sequence ID" value="ACL28834"/>
        <property type="gene ID" value="BLA_0535"/>
    </dbReference>
    <dbReference type="GeneID" id="66533665"/>
    <dbReference type="KEGG" id="bla:BLA_0535"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.564"/>
    <dbReference type="HOGENOM" id="CLU_047479_0_1_11"/>
    <dbReference type="OMA" id="HHPNKAD"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016726">
        <property type="term" value="F:oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00102">
        <property type="entry name" value="DapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022664">
        <property type="entry name" value="DapB_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00036">
        <property type="entry name" value="dapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01298">
        <property type="entry name" value="DAPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword id="KW-0457">Lysine biosynthesis</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000118843" description="4-hydroxy-tetrahydrodipicolinate reductase">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="76"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="108"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="148"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="253" mass="26772" checksum="34AC9B79FF2FF8B3" modified="2009-03-03" version="1">MIRVSVVGAKGRMGSHVVEAVRAADDTELALALDAGDDLTQITPQNTDVVVEFTVPAVSLNNVLTLVRQGVNVVVGTTGWTDEKLDQVRAALAETETIDGRKQSVFIAPNFAISAVLADVFARIAAPYFESAEVIELHHPDKVDAPSGTAIHTAHAIADARKAAGLGEMPDNTQTDDGSRGAVIDGVHVHAVRLRGLNAHEEVLLGNAGEQLVIRADSFDRISFMPGVLLAVRKVDSGEFPGLTVGLDQFLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWI7</accession>
    <name>B8DWI7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATP-dependent exoDNAse (Exonuclease V) beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0539"/>
    <dbReference type="EnsemblBacteria" id="ACL28838">
        <property type="protein sequence ID" value="ACL28838"/>
        <property type="gene ID" value="BLA_0539"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0539"/>
    <dbReference type="HOGENOM" id="CLU_003219_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDDEXK_1" evidence="2">
        <location>
            <begin position="501"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="905" mass="98306" checksum="335173BFF9903D6D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWJ2</accession>
    <name>B8DWJ2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transglutaminase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0544</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218263.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0544"/>
    <dbReference type="EnsemblBacteria" id="ACL28843">
        <property type="protein sequence ID" value="ACL28843"/>
        <property type="gene ID" value="BLA_0544"/>
    </dbReference>
    <dbReference type="GeneID" id="66533674"/>
    <dbReference type="KEGG" id="bla:BLA_0544"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.573"/>
    <dbReference type="HOGENOM" id="CLU_012121_2_0_11"/>
    <dbReference type="OMA" id="YPTPKET"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="671"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="3">
        <location>
            <begin position="514"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="829" mass="88971" checksum="9D9774D0BE0AD0A7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWL7</accession>
    <name>B8DWL7_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nudC</name>
        <name evidence="8" type="ordered locus">BLA_0571</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218303.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0571"/>
    <dbReference type="EnsemblBacteria" id="ACL28868">
        <property type="protein sequence ID" value="ACL28868"/>
        <property type="gene ID" value="BLA_0571"/>
    </dbReference>
    <dbReference type="GeneID" id="66533699"/>
    <dbReference type="KEGG" id="bla:BLA_0571"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.602"/>
    <dbReference type="HOGENOM" id="CLU_037162_0_4_11"/>
    <dbReference type="OMA" id="TIARYMI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000210">
        <property type="term" value="F:NAD+ diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015376">
        <property type="entry name" value="Znr_NADH_PPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09297">
        <property type="entry name" value="zf-NADH-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="230"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="369" mass="41039" checksum="5FD006D466AA7C4A" modified="2009-03-03" version="1">MFAPLALTQALPYLPLAQGDIDYQVERRADPQLIEQVLQMPSTCVLLCRKGKVAVPFGQHNMAQLAASRMRLATLPGSYVARALEHGNNGVVAMYLGRYKGAHDEHAIALDLTAVEEGEELRRVEERAAAAGHAVDAAFGDDVDARESADSNAVNMFEQAVERFDWVDLRMFAPHASSREIGQAVTMLSLANWHDMQRHCPHCGAPTEPAMSGWAQRCTSESDDHRILFPRVEPAVICTVVDAKDRLLLQHNRAWKHSNLFSVSAGFVETGENLEHACRRETMEETGIRVGEVKYLGSQPWPFPFSLMMGFKAQALSNDIHVDGDETIAARWVTRDEYTNLLVTGEIEAPGKATIARVMIEEWYGRELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWM4</accession>
    <name>B8DWM4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28875">
        <property type="protein sequence ID" value="ACL28875"/>
        <property type="gene ID" value="BLA_0578"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0578"/>
    <dbReference type="HOGENOM" id="CLU_607900_0_0_11"/>
    <dbReference type="OMA" id="ETHMEAT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018674">
        <property type="entry name" value="DUF2142_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09913">
        <property type="entry name" value="DUF2142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="444" mass="49896" checksum="148D3F426890B803" modified="2009-03-03" version="1">MRESWKMMALFLIISMVEGIAFITTTAPLTMADPDMHLPSTYALATGQSFNITRAPESHRQYDPRTSEVPSSMPVGGRQLLTGEARYLQGSVNGAKNALVESINPFDLTRNDEYATQCDRLNNLAEGERIITTPTRSNQYMFFAYIPQAIGMKFGFLTHANPSTCINYARASNLVCYLLLFLLAIAVIPTAKGIIALLGMLPLPVFCSSTLMTDGTLFAAVALFIAVCVRLMQRERRLNNWQVAALTVGTCLICFLKYVYIPIILLPWLACKALSGKQKVWYTASTVLVVGATVLCWQKFFGYNPERVEGLYAYNFNAALHNPFGTTFRILANVFLTTFNMVQSNPTLIVCLILLLIAWMFGQDARIAVPRRTTMQVYTLVGFIVFATLFLMYIPFLLTWTLPSESLRLDGLQVRYYYPILPLLVIPFIYRYKTGTKDLVTVHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWM5</accession>
    <name>B8DWM5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Possible glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619772.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0579"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28876">
        <property type="protein sequence ID" value="ACL28876"/>
        <property type="gene ID" value="BLA_0579"/>
    </dbReference>
    <dbReference type="GeneID" id="66533707"/>
    <dbReference type="KEGG" id="bla:BLA_0579"/>
    <dbReference type="HOGENOM" id="CLU_033536_7_3_11"/>
    <dbReference type="OMA" id="VCILIPT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="9"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="335" mass="37221" checksum="69C9BF2E4AE6C5B5" modified="2009-03-03" version="1">MTTHQTTAVLIPCLNEEQTIGKVVADFRRELPDAVIYVYDNASDDRTSQVAADAGAIVRMAPERGKGNVLRRMLRDIDADRYVLVDGDDTYPAEDVHTLLDTLDQGWDMVVGDRLSSTYFTENKRPFHNTGNRLVRSAINSTFHAQIRDVMSGYRVFDNLFAKAYGVMSNGFEIETEMTIFALDRKLRVTEVPIQYRDRPEGSTSKLSTFSDGAKVLNLIFRLAYENRPLPFFGTLGGIIGGVGLGLALWVCIEFAQTGMVRRFPLLIGSTMLMIIGVIAVFTGLVLAVFARKDRSRFAFAAQTYIAASGRHPSVSEPYRACVDEVSHEPVTDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWP1</accession>
    <name>B8DWP1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Galactosyl transferase CpsD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BLA_0595</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619778.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0595"/>
    <dbReference type="EnsemblBacteria" id="ACL28892">
        <property type="protein sequence ID" value="ACL28892"/>
        <property type="gene ID" value="BLA_0595"/>
    </dbReference>
    <dbReference type="GeneID" id="66533725"/>
    <dbReference type="KEGG" id="bla:BLA_0595"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.627"/>
    <dbReference type="HOGENOM" id="CLU_024920_3_0_11"/>
    <dbReference type="OMA" id="YWRFFVN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="8">
        <location>
            <begin position="317"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL28892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="511" mass="57478" checksum="FF30D0CE8FDBB2F3" modified="2009-03-03" version="1">MAQAKSDAQLAEEVDVRSSRVLRWRFVMNLALMLFDALVYFATSMIVLVVSHGTNLVTTRLQLNLPIDPWLYSAACAAIYVYCMHVAGVYHRHVFADGYQLNMLLLKGGFIAWVAICALNFIIQCNIFFYMVCLTSLIVWVAEMIVRFIARVILTSKHRKGEYSYPTVIVGSPEGIGQILKFLNQRRQLNYKPIRLCPIRVNSETGLIEADPNTELLSKEVHESWNSPIDVIEYGPQLAGRIAETGAQTVMVTDVLDRFSDNLSTFALQMESVNLEIALITSALDIAEHATQMRNIQGMSIMTISLPQYSPSAQIKKRVFDLVVSTIAIILSSPIMLIVALAIKIEDGGPVFYKQERIGLRGKPFYIHKFRSMRVDADAHLKEVLAAQGQELGARYKLKHDPRITKVGNFIRKTSLDELPQFFDVFMGSMSVVGPRPQRSFEVAEYDPVYATRLLVKPGITGPWQVSGRNDLNEEESRQLDVSYVQDWSVMGDVVYILRTIGTVLHPSGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWQ3</accession>
    <name>B8DWQ3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619780.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0611"/>
    <dbReference type="EnsemblBacteria" id="ACL28904">
        <property type="protein sequence ID" value="ACL28904"/>
        <property type="gene ID" value="BLA_0611"/>
    </dbReference>
    <dbReference type="GeneID" id="66533742"/>
    <dbReference type="KEGG" id="bla:BLA_0611"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.642"/>
    <dbReference type="HOGENOM" id="CLU_020572_0_0_11"/>
    <dbReference type="OMA" id="PSMMGAD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025101">
        <property type="entry name" value="DUF4012"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13196">
        <property type="entry name" value="DUF4012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="609" mass="66593" checksum="07D46B43A236BD3A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSJ5</accession>
    <name>B8DSJ5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Possible sortase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0681</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219103.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="MEROPS" id="C60.007"/>
    <dbReference type="EnsemblBacteria" id="ACL28974">
        <property type="protein sequence ID" value="ACL28974"/>
        <property type="gene ID" value="BLA_0681"/>
    </dbReference>
    <dbReference type="GeneID" id="66533814"/>
    <dbReference type="KEGG" id="bla:BLA_0681"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.710"/>
    <dbReference type="HOGENOM" id="CLU_045680_1_3_11"/>
    <dbReference type="OMA" id="AMMFTRL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05827">
        <property type="entry name" value="Sortase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042002">
        <property type="entry name" value="Sortase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01076">
        <property type="entry name" value="sortase_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="342" mass="37188" checksum="ABE0FF37C4C41352" modified="2009-03-03" version="1">MRRKRRNGGEGTAARQWQPLTFEQATDVADVVQLRRSLRRRMIALRVFAIVLAIVAVVVGATPFVLQWRSSQQLSAQTRMVNQRVLGWPYPQAENKLRDARAYNQRLAASGQPILGEAVDPFSQRAGGSSVSEKGDSAASKDSEYQSLLDTGGGIMGSVSIPKISVNLPIYHGTSEEALAAGAGHLYGTSLPAGGLNTHAVITGHRGLVDAPMFTRLDEIKNGDYFYIDVMGEKLAYAVDSITVINPDDTSRLRVVPGEDRVTLMTCTPYGVNTQRLLVSGHRVSIPYPAPNPSDVHDGRLVGIMAAIVALAIGLIAATWFSRARTRVERMRHARPDDVMSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSJ9</accession>
    <name>B8DSJ9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycerol uptake facilitator-like protein in Mip family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glpF</name>
        <name evidence="8" type="ordered locus">BLA_0685</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219099.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0685"/>
    <dbReference type="EnsemblBacteria" id="ACL28978">
        <property type="protein sequence ID" value="ACL28978"/>
        <property type="gene ID" value="BLA_0685"/>
    </dbReference>
    <dbReference type="GeneID" id="66533818"/>
    <dbReference type="KEGG" id="bla:BLA_0685"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.714"/>
    <dbReference type="HOGENOM" id="CLU_020019_9_2_11"/>
    <dbReference type="OMA" id="FTSHHYY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="244" mass="26451" checksum="FCE94E8C56D21C4F" modified="2009-03-03" version="1">MEYSLFTKLAAEFVGTAVLMIFGNGAVANVELKNTKGHNAGWLNIAMGYGFGVMFPVLMFGGVSGAHINPAMTIAQAVNGMFPWSNVLPYIIAQILGAAVGQLIVYVCYYPHYKETENAEAILSTFCTTDAQATRRNYFINEFFGTMILVLGALCCLELQWGRQNYASASIVVGFIVWGLVCSMGGPTGPGLNPARDLMPRVLHSILPIPHKGSSRWNEAWIPVVAPIIGGIIGCWLFHVLFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSN1</accession>
    <name>B8DSN1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218726.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0717"/>
    <dbReference type="EnsemblBacteria" id="ACL29010">
        <property type="protein sequence ID" value="ACL29010"/>
        <property type="gene ID" value="BLA_0717"/>
    </dbReference>
    <dbReference type="GeneID" id="66533478"/>
    <dbReference type="KEGG" id="bla:BLA_0717"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.748"/>
    <dbReference type="HOGENOM" id="CLU_069776_1_0_11"/>
    <dbReference type="OMA" id="FDGPRWF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022183">
        <property type="entry name" value="DUF3710"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12502">
        <property type="entry name" value="DUF3710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="285" mass="31120" checksum="C2F6C4970853A572" modified="2009-03-03" version="1">MGLFGFGRKKKKQQDDERLAEAVDSRTEDVAVEDSEDDEQTEVLEGARTEVGVDYEGRGETVGPWDVDDANAPDYDEYLSLGAYYLPFVQGIQLRIKANNATHEIVGATMTIGNSSLEVEAFAAPKTMGLWDDVREDLLASNPEAEAVDGIFGTEVKLPVKLPNGKTAHTRIVGVDGPRWMLRGIFSGKAASDPDGTETKILNDAFAQIVVERGDEPLSPRDPIPMARPLTPNERRALAAQEEDGDLAGDDHSKIPGRPDGPLSTDQQVEQQTTLRRGPMFSEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSQ6</accession>
    <name>B8DSQ6_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <shortName evidence="5">HMBPP reductase</shortName>
            <ecNumber evidence="5">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">ispH</name>
        <name evidence="6" type="ordered locus">BLA_0742</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24488"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24825"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IspH family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="5"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0742"/>
    <dbReference type="EnsemblBacteria" id="ACL29035">
        <property type="protein sequence ID" value="ACL29035"/>
        <property type="gene ID" value="BLA_0742"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0742"/>
    <dbReference type="HOGENOM" id="CLU_027486_1_0_11"/>
    <dbReference type="OMA" id="HNKYVVD"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426">
        <property type="entry name" value="PTHR30426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="241"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="331" mass="35918" checksum="3C5D2D9B1EC35D51" modified="2009-03-03" version="1">MRRKAGMTKRIILANPRGFCAGVDRAIQSVQTILNTAAPREDDLPPVYVRRQIVHNRHVVDELAEQGAVFVDELSEIPQAAAQAGIPVVFSAHGVSPQVVREANELGMSVVDASCPLVSKVHREVLRFVREGYEIVYIGHRGHDEAVGVIGESPEHVHLIEHERDVDDLDFSPDQKLVLLSQTTLSVDETTGTIAALQRRFPWIELPPSSDICYATSNRQAAVKLVAEQADAMVIVGSANSSNSVRLMEVANEALGGRGTAHRVDDADELDSAWFEGVSAVGVSSGASVPDELVQGVIDALQRLGFTEVDTVETIEENMHFVLPAALRKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSS6</accession>
    <name>B8DSS6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218666.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29055">
        <property type="protein sequence ID" value="ACL29055"/>
        <property type="gene ID" value="BLA_0762"/>
    </dbReference>
    <dbReference type="GeneID" id="66533523"/>
    <dbReference type="KEGG" id="bla:BLA_0762"/>
    <dbReference type="HOGENOM" id="CLU_2876773_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="63" mass="7150" checksum="E3AC55A98FBCAA6E" modified="2009-03-03" version="1">MNTTQEALKELHRDIARMFDTLIAHVGDDTAAWHQAALLSMIDGRIVAILATTTSKEENRWDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DST2</accession>
    <name>B8DST2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage prohead protease, HK97 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218658.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0768"/>
    <dbReference type="EnsemblBacteria" id="ACL29061">
        <property type="protein sequence ID" value="ACL29061"/>
        <property type="gene ID" value="BLA_0768"/>
    </dbReference>
    <dbReference type="GeneID" id="66533530"/>
    <dbReference type="KEGG" id="bla:BLA_0768"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.800"/>
    <dbReference type="HOGENOM" id="CLU_478066_0_0_11"/>
    <dbReference type="OMA" id="MNDNINT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024455">
        <property type="entry name" value="Phage_capsid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006433">
        <property type="entry name" value="Prohead_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04586">
        <property type="entry name" value="Peptidase_S78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05065">
        <property type="entry name" value="Phage_capsid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01554">
        <property type="entry name" value="major_cap_HK97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01543">
        <property type="entry name" value="proheadase_HK97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1188">Viral release from host cell</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="587" mass="64304" checksum="865B0767280D1336" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSX2</accession>
    <name>B8DSX2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YggT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218601.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0809"/>
    <dbReference type="EnsemblBacteria" id="ACL29101">
        <property type="protein sequence ID" value="ACL29101"/>
        <property type="gene ID" value="BLA_0809"/>
    </dbReference>
    <dbReference type="GeneID" id="66533571"/>
    <dbReference type="KEGG" id="bla:BLA_0809"/>
    <dbReference type="HOGENOM" id="CLU_136788_5_0_11"/>
    <dbReference type="OMA" id="QFARSWR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003425">
        <property type="entry name" value="CCB3/YggT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02325">
        <property type="entry name" value="YGGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="96" mass="11451" checksum="3BCC2A14F19D3487" modified="2009-03-03" version="1">MLSTLFGFFFHIVDLLIEAYIAVLFARMIFDWVLVLAPRWRPTGFVATLLRIIYQLTEPPLRFLRRYIKPIPLGRVYFDVSFLVLYFVLVILRILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT14</accession>
    <name>B8DT14_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="2">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">panE</name>
        <name evidence="5" type="ordered locus">BLA_0851</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218540.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0851"/>
    <dbReference type="EnsemblBacteria" id="ACL29143">
        <property type="protein sequence ID" value="ACL29143"/>
        <property type="gene ID" value="BLA_0851"/>
    </dbReference>
    <dbReference type="GeneID" id="66533613"/>
    <dbReference type="KEGG" id="bla:BLA_0851"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.887"/>
    <dbReference type="HOGENOM" id="CLU_031468_0_0_11"/>
    <dbReference type="OMA" id="WEKWVFL"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00004"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="3">
        <location>
            <begin position="4"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="ApbA_C" evidence="4">
        <location>
            <begin position="190"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="336" mass="37649" checksum="2BE342F459809920" modified="2009-03-03" version="1">MKYAILGAGGMGIQYGVLLQEFAHQQVDFVDTWTENVEKIREQGGAYVSQDGEGRHLVPINVYYPEEYAGDPDVWIVFVKQHQLPEFLERTAPHFREHQVVFSAMNGYGHFEKLAEYFPKHRIYGGTALIGAYVYGPGDFNFTGGAHAKAMNLCAYDEHDVEEDPIERQLFADFQAATLNPTIVRHFLGMCLAKIVFNSVLNTLCTMYQIRFGEFASHPAAPILTERLVDEAYGAAEAAGVQLLGTRESEVETIMHTASIAHPLHYPSMYQDLTRCRPTEVDYINGYIARLGREHGYACPLHEFVTQEVHLAEHAFAIHHPDIAAKAASQSVELAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT15</accession>
    <name>B8DT15_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218538.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0852"/>
    <dbReference type="EnsemblBacteria" id="ACL29144">
        <property type="protein sequence ID" value="ACL29144"/>
        <property type="gene ID" value="BLA_0852"/>
    </dbReference>
    <dbReference type="GeneID" id="66533614"/>
    <dbReference type="KEGG" id="bla:BLA_0852"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.888"/>
    <dbReference type="HOGENOM" id="CLU_061829_2_0_11"/>
    <dbReference type="OMA" id="IHLMCKE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="219" mass="24219" checksum="360EFB448485DCD1" modified="2009-03-03" version="1">MLVRHATLDDLDALAAVEAACFPPQEAADIDQLANRVESYPNHFWLLVNPAEPDNDCFPAQVDDGMLVSFIDGPCVGSPDLTDDMYASTALHADDAPWQMILGVNTAPMYQHRGCASFLMRHVILDSALSHRHGIVLACKEKMLPFYSSFGFIDEGRSQSVHGNAVWHQMRLPFTTSADARDDAPGADIRQATITMAMHETTAYMDHERTITSQFPQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT36</accession>
    <name>B8DT36_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219231.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0873"/>
    <dbReference type="EnsemblBacteria" id="ACL29165">
        <property type="protein sequence ID" value="ACL29165"/>
        <property type="gene ID" value="BLA_0873"/>
    </dbReference>
    <dbReference type="GeneID" id="66533852"/>
    <dbReference type="KEGG" id="bla:BLA_0873"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.912"/>
    <dbReference type="HOGENOM" id="CLU_022171_0_0_11"/>
    <dbReference type="OMA" id="AREFACL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="510"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="658"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="696"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="749" mass="84165" checksum="E893E2D9840E00C5" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT37</accession>
    <name>B8DT37_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative riboflavin-specific deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219233.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29166">
        <property type="protein sequence ID" value="ACL29166"/>
        <property type="gene ID" value="BLA_0874"/>
    </dbReference>
    <dbReference type="GeneID" id="66533853"/>
    <dbReference type="KEGG" id="bla:BLA_0874"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.914"/>
    <dbReference type="HOGENOM" id="CLU_503153_0_0_11"/>
    <dbReference type="OMA" id="HIDSPTI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="543" mass="61423" checksum="C93010F4B4E84CE8" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT52</accession>
    <name>B8DT52_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="6 12">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">BLA_0889</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 12">
            <text>a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="6 12"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219287.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0889"/>
    <dbReference type="CAZy" id="GT39">
        <property type="family name" value="Glycosyltransferase Family 39"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29181">
        <property type="protein sequence ID" value="ACL29181"/>
        <property type="gene ID" value="BLA_0889"/>
    </dbReference>
    <dbReference type="GeneID" id="66533868"/>
    <dbReference type="KEGG" id="bla:BLA_0889"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.931"/>
    <dbReference type="HOGENOM" id="CLU_021079_0_0_11"/>
    <dbReference type="OMA" id="AGNHHPW"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="GlyclTrfase_39-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="Glyco_trans_39/83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="PTHR10050"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="PMT" evidence="13">
        <location>
            <begin position="121"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_4TMC" evidence="14">
        <location>
            <begin position="346"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ACL29181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="537" mass="60313" checksum="B2999041FE0E3229" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT60</accession>
    <name>B8DT60_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chaperone protein-like DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219274.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0897"/>
    <dbReference type="EnsemblBacteria" id="ACL29189">
        <property type="protein sequence ID" value="ACL29189"/>
        <property type="gene ID" value="BLA_0897"/>
    </dbReference>
    <dbReference type="GeneID" id="66533877"/>
    <dbReference type="KEGG" id="bla:BLA_0897"/>
    <dbReference type="HOGENOM" id="CLU_017633_0_0_11"/>
    <dbReference type="OMA" id="RVCPTCV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="10"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="351" mass="37132" checksum="4DFDC1839CBCF98D" modified="2009-03-03" version="1">MAENDWLNKDFYKTLGVSKDADEKEITKAYRKLARKYHPDINKTKEGEEKFKDISEAYDVLKDKDSRQKYDAIRSFGAGGARFTGGAGGGGFNAGDFSDIFGSMFGGGGGNGGSHIRFSTNGGGSHGAGFDDIFSMFGGGAGNGGFGGGRGYGDYSDGAYAGYRPAPHPEDGDDLSSKITLTFRQAVKGATVSLKAAGKKFKTKVPAGVKNGQKIKIAGKGKPGQHGGKPGDMYLTVTVTEDPKFTMDGKDLVMDLPITVGQAVDGAKISARDFDGNDVTFKVEKGTSSGEEVRVRGKGVETRTGTGDLVGRIQIRVPKHPTMGEKHAAKEFDKACGDFVEELATENTETK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT62</accession>
    <name>DNAK_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dnaK</name>
        <name type="ordered locus">BLA_0899</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="1">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219269.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DT62"/>
    <dbReference type="SMR" id="B8DT62"/>
    <dbReference type="STRING" id="442563.BLA_0899"/>
    <dbReference type="PRIDE" id="B8DT62"/>
    <dbReference type="EnsemblBacteria" id="ACL29191">
        <property type="protein sequence ID" value="ACL29191"/>
        <property type="gene ID" value="BLA_0899"/>
    </dbReference>
    <dbReference type="GeneID" id="66533879"/>
    <dbReference type="KEGG" id="bla:BLA_0899"/>
    <dbReference type="HOGENOM" id="CLU_005965_2_1_11"/>
    <dbReference type="OMA" id="ISIKRHM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_1000133132" description="Chaperone protein DnaK">
        <location>
            <begin position="1"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="583"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="499"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="1">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="621" mass="66754" checksum="FB0F508170464873" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTA1</accession>
    <name>B8DTA1_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">trpD</name>
        <name evidence="6" type="ordered locus">BLA_0938</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate</text>
            <dbReference type="Rhea" id="RHEA:11768"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217600.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0938"/>
    <dbReference type="EnsemblBacteria" id="ACL29230">
        <property type="protein sequence ID" value="ACL29230"/>
        <property type="gene ID" value="BLA_0938"/>
    </dbReference>
    <dbReference type="GeneID" id="66533448"/>
    <dbReference type="KEGG" id="bla:BLA_0938"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.981"/>
    <dbReference type="HOGENOM" id="CLU_034315_4_1_11"/>
    <dbReference type="OMA" id="GPMTNPA"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="1 3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycos_trans_3N" evidence="5">
        <location>
            <begin position="7"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_3" evidence="4">
        <location>
            <begin position="77"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="93"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="111"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="350" mass="36284" checksum="9903798AC52397F9" modified="2009-03-03" version="1">MADITWKSILTKLVQGNHLTAEESEWFVDDLMKGNANPAAVGAVLATQQQLGLTADEIAGAAKAMVSHAVPLEVNRECTDIVGTGGDGAHTVNLSTMGAVIAAAAGVTIVKHGNRAASSKCGAADCLEALGLPLDLKPQAVAEVADEVGITFAFAKTFHPAMRFVGPVRAALGVPCVFNVLGPLTNPATPKHMAIGCANRAMSPIMAAVYAANGQSGMVYTSNEGLDEMAPTGPISVWEFKDGKVCETEFDPIEELGLAKVTIEDLRGGEPDYNAQAARDLFAGKDVPFRTTALLNAASAIVADGSLIDASAPLGERFRQAHAIAEQAVDSGRAAALLDEWIAVASKHVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTB4</accession>
    <name>B8DTB4_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gyrA</name>
        <name evidence="8" type="ordered locus">BLA_0953</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0953"/>
    <dbReference type="EnsemblBacteria" id="ACL29243">
        <property type="protein sequence ID" value="ACL29243"/>
        <property type="gene ID" value="BLA_0953"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0953"/>
    <dbReference type="HOGENOM" id="CLU_002977_6_1_11"/>
    <dbReference type="OMA" id="ATGGVRC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="7">
        <location>
            <begin position="23"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="982" mass="106019" checksum="E9FA6C758E905AF3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTB6</accession>
    <name>B8DTB6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0955"/>
    <dbReference type="EnsemblBacteria" id="ACL29245">
        <property type="protein sequence ID" value="ACL29245"/>
        <property type="gene ID" value="BLA_0955"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0955"/>
    <dbReference type="HOGENOM" id="CLU_021151_2_1_11"/>
    <dbReference type="OMA" id="QWDSWRR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021421">
        <property type="entry name" value="DUF3071"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11268">
        <property type="entry name" value="DUF3071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="432" mass="47574" checksum="93F47199D88E4745" modified="2009-03-03" version="1">MGTGSFPAAQFDHVTPDGDLVFTADGMPFLVRVDDTFERAMLEAKQIRSEKRITTAVHQQRTLPISQIQSLIRAGADPEHIARQYELSEVIVRRFATSIEAEKKYAIEQFLRVRAPKESKVRTLSELIDRTLAAARVRPESVQWKATRRGLEPWRISATFISAGHRIHAEWSWNMHDNTVVCINNAASKLIGEMGSVTGASFDDAGTQTALDEALPSSVDLPGDSARSARIEQTMRAWNGSGNEEPSNEQETLTTNETEARTATDTARAADAYAHATMDAMPEDAGTTPAEEASQSESAPSAVEEPVQKGTDTSSQSDSPHSDDAPEPAPSQEHRPDEPSQLRKRVPISALYPKQKAPAQFTPKNTGAQRPAIKPDAVQSQPEQHGDDDTPTQQQPQVHRNTSEQHSPHRSNRASMPSWDEIMFGKDPHKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTC1</accession>
    <name>B8DTC1_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BLA_0960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269135.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0960"/>
    <dbReference type="EnsemblBacteria" id="ACL29250">
        <property type="protein sequence ID" value="ACL29250"/>
        <property type="gene ID" value="BLA_0960"/>
    </dbReference>
    <dbReference type="GeneID" id="66533429"/>
    <dbReference type="KEGG" id="bla:BLA_0960"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1003"/>
    <dbReference type="HOGENOM" id="CLU_012062_16_3_11"/>
    <dbReference type="OMA" id="ELYNDHA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="179" mass="19442" checksum="8104D153853C0638" modified="2009-03-03" version="1">MSTIIMHTSEGDIKINLFDEQTPKTVENFLGLASGKKEWTDPFTGKPSHEAFYDGLTFHRIIKDFMIQGGCPLGTGTGGPGYDFDDEIDPSLKFDKPYLLAMANAGLRRGADGKIHGTNGSQFFITTVPTPWLNGHHTIFGEVADEASRAVVATIDGVATDAQDRPLEPVMIEGIEIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTE9</accession>
    <name>B8DTE9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Possible ATP binding protein of ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_0988</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0988"/>
    <dbReference type="EnsemblBacteria" id="ACL29278">
        <property type="protein sequence ID" value="ACL29278"/>
        <property type="gene ID" value="BLA_0988"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0988"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OMA" id="ADRANDW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="15"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="249"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="304" mass="33099" checksum="7ECC191DA8778109" modified="2009-03-03" version="1">MVDQIHQPTHTPVAIEAIDLVKDYGTGESLVHALKDVNVQFEQGRFTAIMGPSGSGKSTLMHVMSGLDSATSGSVVFQGRDLTKLNDKQLTLLRRNYIGFIFQSFNLLPMFTAEQNIVMPLTLAGKKVDRAWFDRLVDTLGLRERLGHRPNELSGGQQQRVAIARALITRPSLVFADEPTGALDSASSAEVLGFLKASVRELGQTIIMVTHDPVAASYADRAIVFSDGHIIADVSDPQPAQMSDLLMKERERSTKTAGRSAVQTMPANQNPPIARQPRNNPADIGGQPAQGTLMQAPKPPQQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTG3</accession>
    <name>B8DTG3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Copper-translocating P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BLA_1002</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619904.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1002"/>
    <dbReference type="EnsemblBacteria" id="ACL29292">
        <property type="protein sequence ID" value="ACL29292"/>
        <property type="gene ID" value="BLA_1002"/>
    </dbReference>
    <dbReference type="GeneID" id="66533385"/>
    <dbReference type="KEGG" id="bla:BLA_1002"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1045"/>
    <dbReference type="HOGENOM" id="CLU_001771_11_1_11"/>
    <dbReference type="OMA" id="ACGMNMV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007029">
        <property type="entry name" value="YHS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04945">
        <property type="entry name" value="YHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="786"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="811"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="TRASH" evidence="8">
        <location>
            <begin position="896"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL29292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="941" mass="100404" checksum="E746D43C070241E8" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTG8</accession>
    <name>B8DTG8_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="3 6">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gnd</name>
        <name evidence="8" type="ordered locus">BLA_1007</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 6">
            <text>6-phospho-D-gluconate + NADP(+) = CO2 + D-ribulose 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 6">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="3 6"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217685.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1007"/>
    <dbReference type="EnsemblBacteria" id="ACL29297">
        <property type="protein sequence ID" value="ACL29297"/>
        <property type="gene ID" value="BLA_1007"/>
    </dbReference>
    <dbReference type="GeneID" id="66533381"/>
    <dbReference type="KEGG" id="bla:BLA_1007"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1049"/>
    <dbReference type="HOGENOM" id="CLU_024540_4_2_11"/>
    <dbReference type="OMA" id="VIMVKAG"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="3 6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="7">
        <location>
            <begin position="181"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="130"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="188"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="485" mass="52813" checksum="F08D028222D8CA67" modified="2009-03-03" version="1">MSAPANVGVVGLAAMGASLARNLARHGNAVAIYNRHYSRTEKLMEEYGDEGAFYPAKTVKEFVDLLERPRTAIIMVKAGSATDAVINELAEYMEPGDIIVDGGNAYFKDTIRRERELRAKGLHFVGMGVSGGEEGALLGPSMMPGGSDESWERLKPILESIAAKATDGEPCVMHVGENGAGHFVKMVHNGIEYADMQLIAESYDIMRRGLNMTPDEIGGVFESWNKTDLDSYLIEITAEVLHKKDPRTGKPLVDVIVDHAGMKGTGTWTVQTALELGVPVTGIAEAVFARGLSDQNVLREMAQQNPFAGPDGHIDLGDLSREEFIGQIRNALYASKIIAYAQGFNEISVAARTYGWNIDMAHLARIWRAGCIIRAQFLDRISEAFESGQADVSLLFAPYFKSGIEHSEADWRSVVATSAKSGLPAPVFSSSLAYFDGLRAKRLPAALTQGQRDLFGAHTYGRVDMPGAYHILWATPEQNEVKISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTM2</accession>
    <name>B8DTM2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218759.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29351">
        <property type="protein sequence ID" value="ACL29351"/>
        <property type="gene ID" value="BLA_1063"/>
    </dbReference>
    <dbReference type="GeneID" id="66532892"/>
    <dbReference type="KEGG" id="bla:BLA_1063"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1111"/>
    <dbReference type="HOGENOM" id="CLU_1851251_0_0_11"/>
    <dbReference type="OMA" id="RSAMYII"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="143" mass="16169" checksum="BCAF3A9B0CF38E90" modified="2009-03-03" version="1">MKHSAMYIISGIGALVLFVAFLFYTSAPVNLVGWFKLSDLLTIIGGLMFIIPFYIVSVRRKMRDNAPNPWAWQYLPVIGMVLMVIGLIFPNGKLTVGVIDLCDVLYLFGCVFMLMIFVYPFGSVNEEMLESDVDERVDDDARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTM5</accession>
    <name>B8DTM5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metalloendopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29354">
        <property type="protein sequence ID" value="ACL29354"/>
        <property type="gene ID" value="BLA_1066"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1066"/>
    <dbReference type="HOGENOM" id="CLU_201632_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="PTHR11733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M13" evidence="2">
        <location>
            <begin position="3"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="72" mass="8761" checksum="E29E19637A182869" modified="2009-03-03" version="1">MQVQRFFLGYAQIWRTKMRDELAEQYLQIDPHSPAEDRTNGIARNVNLFYKAFGVTDNDRMWLKPEERVRIW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTN1</accession>
    <name>RLMH_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase H</fullName>
            <ecNumber evidence="1">2.1.1.177</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA (pseudouridine1915-N3)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">23S rRNA m3Psi1915 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (pseudouridine-N3-)-methyltransferase RlmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rlmH</name>
        <name type="ordered locus">BLA_1072</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10221"/>
            <dbReference type="Rhea" id="RHEA-COMP:10222"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:74486"/>
            <dbReference type="EC" id="2.1.1.177"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA methyltransferase RlmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.177" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218768.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DTN1"/>
    <dbReference type="SMR" id="B8DTN1"/>
    <dbReference type="STRING" id="442563.BLA_1072"/>
    <dbReference type="EnsemblBacteria" id="ACL29360">
        <property type="protein sequence ID" value="ACL29360"/>
        <property type="gene ID" value="BLA_1072"/>
    </dbReference>
    <dbReference type="GeneID" id="66532899"/>
    <dbReference type="KEGG" id="bla:BLA_1072"/>
    <dbReference type="HOGENOM" id="CLU_100552_0_0_11"/>
    <dbReference type="OMA" id="NEPYHHQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070038">
        <property type="term" value="F:rRNA (pseudouridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18081">
        <property type="entry name" value="RlmH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00658">
        <property type="entry name" value="23SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003742">
        <property type="entry name" value="RlmH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33603">
        <property type="entry name" value="PTHR33603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02590">
        <property type="entry name" value="SPOUT_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004505">
        <property type="entry name" value="MT_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00246">
        <property type="entry name" value="tRNA_RlmH_YbeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000199811" description="Ribosomal RNA large subunit methyltransferase H">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="127"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00658"/>
        </source>
    </evidence>
    <sequence length="159" mass="18186" checksum="89A05ACA1270F015" modified="2009-03-03" version="1">MNIDIVCVGKVKERYLRDAIDEYRKRLSRFAKVDVIEVADEKTPEHASDTLNAQIKEKEGERILKHLRDGAFVVALAIEGDQLTSEQLAARIAQWGLHGVSHLQFVIGGSLGLDPRVLRRANMPLSFSKMTFPHQLMRVILLEQIYRAFKINAHEPYHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTN6</accession>
    <name>B8DTN6_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Cell division protein FtsX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ftsX</name>
        <name evidence="14" type="ordered locus">BLA_1077</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Part of the ABC transporter FtsEX involved in cellular division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218773.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1077"/>
    <dbReference type="EnsemblBacteria" id="ACL29365">
        <property type="protein sequence ID" value="ACL29365"/>
        <property type="gene ID" value="BLA_1077"/>
    </dbReference>
    <dbReference type="GeneID" id="66532903"/>
    <dbReference type="KEGG" id="bla:BLA_1077"/>
    <dbReference type="HOGENOM" id="CLU_073546_1_0_11"/>
    <dbReference type="OMA" id="ETGIMRL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004513">
        <property type="entry name" value="ABC_transpt_FtsX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040690">
        <property type="entry name" value="FtsX_ECD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47755">
        <property type="entry name" value="PTHR47755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18075">
        <property type="entry name" value="FtsX_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003097">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10 14" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX_ECD" evidence="13">
        <location>
            <begin position="56"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="12">
        <location>
            <begin position="212"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR003097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACL29365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="307" mass="34176" checksum="C84D3ED8FE7815A3" modified="2009-03-03" version="1">MRFRFILSETWTSLRRNVPMLLSVMLVTFISFLFIGASLLTQAQITKAKGDWYDKVEVVVWLCPDGNSQSANCSTGKAATTAQINELQKVIQQELPNDVSQVTFMSREDFYNNSFVKQYPKGEYQGRTLTAADMQDSLWLKLKNPENYRVVSEVLSNRDGVEEVVDQRQIFEPVFAILNRATVATGGLAVIMVIAAIMLTGTTIRMSAASRREETEIMRLVGASNWTIRLPFILEGVIASLAGSLLSCGALALFVKVFVTDWLAKSVTWIPYVDQTTVWLVSPILIVGAMVLSVLASSIALRRYLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTP0</accession>
    <name>B8DTP0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable solute binding protein of ABC transporter system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_1081</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218779.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1081"/>
    <dbReference type="EnsemblBacteria" id="ACL29369">
        <property type="protein sequence ID" value="ACL29369"/>
        <property type="gene ID" value="BLA_1081"/>
    </dbReference>
    <dbReference type="GeneID" id="66532907"/>
    <dbReference type="KEGG" id="bla:BLA_1081"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1133"/>
    <dbReference type="HOGENOM" id="CLU_019602_18_1_11"/>
    <dbReference type="OMA" id="KVEFSVM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870770" evidence="4">
        <location>
            <begin position="38"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="5">
        <location>
            <begin position="70"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="311" mass="32694" checksum="1233785770116983" modified="2009-03-03" version="1">MFGNAQSTMKKVAAFALGAAVILGSAACGTTDETQTAAKDSQNATSIVDSVKKDDKIAAMLPQKIAESGKLTVGMEMTYAPAEFVAEDGKTPEGYDVDLAKALAKTLGVKADFISSSFDSIVPSVGSKYDLGITAMTITEEREDSVDFVSYYKAGSMWVVKKGNPDKVDAKNLCGTKIAVQVGTTQEEDANKIKEQCAADGKAAVEVMPSKQQTDAATNVVTGKADVFYADSPVAGYAISQTDGQLEELGEVEGTIKQGIAIKKGDTQLAEAVQAAMQHLMDDGTYMKILKAWGVESGALDKAEINPKDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTP6</accession>
    <name>B8DTP6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pseudouridine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1087"/>
    <dbReference type="EnsemblBacteria" id="ACL29375">
        <property type="protein sequence ID" value="ACL29375"/>
        <property type="gene ID" value="BLA_1087"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1087"/>
    <dbReference type="HOGENOM" id="CLU_016902_0_2_11"/>
    <dbReference type="OMA" id="PTRFVYF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="8"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="230" mass="26372" checksum="06A2B3BB235CFF4C" modified="2009-03-03" version="1">MVYENERIIVVDKPHFLATTPRGMWYRETALMRLRERYREPNIIPAHRLDRPTAGIVVFVRDPAARGAYQMLFQEHRTRKCYECLAPIRPLATPRTGTVVHGSPPRIWPLVRRSRIRKTRGVLCAQEIPGQVNAETAIELEALHARMSARMGMSIGVYRLLPRTGKTHQLRVHMNSLGLPIVGDDFYPRIEERAYDDFSQPLQLVARSLAFTDPFTGDPLEFSSKIELGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTQ0</accession>
    <name>B8DTQ0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transporter permease protein for peptides</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BLA_1091</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218802.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1091"/>
    <dbReference type="EnsemblBacteria" id="ACL29379">
        <property type="protein sequence ID" value="ACL29379"/>
        <property type="gene ID" value="BLA_1091"/>
    </dbReference>
    <dbReference type="GeneID" id="66532917"/>
    <dbReference type="KEGG" id="bla:BLA_1091"/>
    <dbReference type="HOGENOM" id="CLU_036879_0_1_11"/>
    <dbReference type="OMA" id="TFVVIQF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="94"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="320" mass="34290" checksum="F7B8FBA771E07C3B" modified="2009-03-03" version="1">MKYVLRRIAMFLVALLAISLIVFLMLRVLPGDIAAVMAGTNSPPERVAQLRAQMGLDKPLPQQYFEWVGGLLHGDFGMTMLTGQPVASVVASRAAITFPLIVLGMLVALLFGIPLGYLAVRTTNRAAKALFQTIAIIGGAIPALWGGLLLILLFARGLGVFEVFPAQGFPSRGWTDPSRALLSLVLPALTVGMIVGATIMRYTRSSLQTIASSGYVEMAMACGMTRRQALWHVGMRLAMPQLVSVIGLTFAEMVTGVMVIENLFALPGIGTGLVSDLGHRDLIAVQSELFMLAAFFLVIGLLVDLTHRALDPRLGEGSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTQ4</accession>
    <name>B8DTQ4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cystathionine gamma-synthase</fullName>
            <ecNumber evidence="4">2.5.1.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">metB</name>
        <name evidence="4" type="ordered locus">BLA_1095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.48" evidence="4"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218806.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1095"/>
    <dbReference type="EnsemblBacteria" id="ACL29383">
        <property type="protein sequence ID" value="ACL29383"/>
        <property type="gene ID" value="BLA_1095"/>
    </dbReference>
    <dbReference type="GeneID" id="66532921"/>
    <dbReference type="KEGG" id="bla:BLA_1095"/>
    <dbReference type="HOGENOM" id="CLU_018986_2_0_11"/>
    <dbReference type="OMA" id="YKQDGVG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102028">
        <property type="term" value="F:cystathionine gamma-synthase activity (acts on O-phosphohomoserine)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="391" mass="41348" checksum="06C3CDA88BDAAE59" modified="2009-03-03" version="1">MTRADTNYAHDGIATRAIHAGQEPDALTGAVSTPIYMTSTFKQDGVGGLRGGYDYSRSVNPTRTSFDEQLAAVEGAAFSMSFSSGLAAIDVLLRATMRPGDSILIGNDVYGGTYRLLSKVFVPWGVELDVVDATDVAALNAALGAKSYRYVWVETPSNPLLGITDIALTAQLAHEHGTKVVVDNTFASPILQHPLADGADAVVYSTTKYIGGHSDVVGGAVLVNDPEVADAVAFLQNAAGAVPSPFDSWLDIRGLKTLGLRVRKHSANALEIAQWLERRPEIERVWYPGLESHPGHEIAARQMHGGFGGMISVQLAGGPEAAQRFASSTRLFTLAESLGGVESLIEVPAAMTHASVSGTTLEVPANLVRLSIGIEDDGDLIADLEQALQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTR6</accession>
    <name>B8DTR6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA or RNA helicase of superfamily II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1107"/>
    <dbReference type="EnsemblBacteria" id="ACL29395">
        <property type="protein sequence ID" value="ACL29395"/>
        <property type="gene ID" value="BLA_1107"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1107"/>
    <dbReference type="HOGENOM" id="CLU_005588_1_0_11"/>
    <dbReference type="OMA" id="YNLAYEI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021835">
        <property type="entry name" value="DUF3427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11907">
        <property type="entry name" value="DUF3427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="246"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="463"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="1020" mass="116927" checksum="7AB8A939942609F0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTS0</accession>
    <name>B8DTS0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Death-on-curing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1111"/>
    <dbReference type="EnsemblBacteria" id="ACL29399">
        <property type="protein sequence ID" value="ACL29399"/>
        <property type="gene ID" value="BLA_1111"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1111"/>
    <dbReference type="HOGENOM" id="CLU_2328157_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="98" mass="11189" checksum="87289E9147BE9359" modified="2009-03-03" version="1">MTFFGITPRERYADVFEQISDFASRFAKDHIFPDGNKRTAVKMALAILAMHGWNVRADDAEEPERNELYQWVQSIVTGRCDAGELAAFLRGHAVRLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTS9</accession>
    <name>B8DTS9_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1-deoxy-D-xylulose-5-phosphate synthase</fullName>
            <ecNumber evidence="6">2.2.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">dxs</name>
        <name evidence="14" type="ordered locus">BLA_1120</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AD011</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="6"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218838.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1120"/>
    <dbReference type="EnsemblBacteria" id="ACL29408">
        <property type="protein sequence ID" value="ACL29408"/>
        <property type="gene ID" value="BLA_1120"/>
    </dbReference>
    <dbReference type="GeneID" id="66532944"/>
    <dbReference type="KEGG" id="bla:BLA_1120"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1174"/>
    <dbReference type="HOGENOM" id="CLU_009227_1_4_11"/>
    <dbReference type="OMA" id="QVGYHAQ"/>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052865">
        <property type="term" value="P:1-deoxy-D-xylulose 5-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02007">
        <property type="entry name" value="TPP_DXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13292">
        <property type="entry name" value="DXP_synthase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="13">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACL29408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="615" mass="66223" checksum="896A915119DA39A0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTT1</accession>
    <name>B8DTT1_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">N5-carboxyaminoimidazole ribonucleotide synthase</fullName>
            <shortName evidence="3 5">N5-CAIR synthase</shortName>
            <ecNumber evidence="3 5">6.3.4.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 5">5-(carboxyamino)imidazole ribonucleotide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5 7" type="primary">purK</name>
        <name evidence="7" type="ordered locus">BLA_1122</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19317"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the PurK/PurT family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.18" evidence="3 5"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218841.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1122"/>
    <dbReference type="EnsemblBacteria" id="ACL29410">
        <property type="protein sequence ID" value="ACL29410"/>
        <property type="gene ID" value="BLA_1122"/>
    </dbReference>
    <dbReference type="GeneID" id="66532946"/>
    <dbReference type="KEGG" id="bla:BLA_1122"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1176"/>
    <dbReference type="HOGENOM" id="CLU_011534_0_1_11"/>
    <dbReference type="OMA" id="ITFDHEH"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034028">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="121"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="162"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="192"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="276"/>
            <end position="277"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="383" mass="41705" checksum="777AECCADC0B1BF3" modified="2009-03-03" version="1">MPSLSDETGGQITRLLPGATIGIVGGGQLGRMMALAAKYMGFRIGTLDPTPDCPTAQVADFQIVADYDDQDAIHELAERSDVLTYEFENVDADALDAVRDIVAIPQGTDLLRVTQNRIAEKTFINDHGIATAPWRPVGSRAELDAALAEIGYPAVLKTCEGGYDGHGQIVLRTPDDLAEVWPDEGFPQAILEGFVDFAFEASILVSGNGDDYQTFPIVRNIHRDNILHLTLAPADVDEQVARTAHELALELARGFKLAGTLAIELFVKADGTVIVNELAPRPHNSGHYTIEACDFDQFDMHVLGIAGWNLPTPRLLSPAVMVNVLGQHIAPTQAVEPMHPEWHVHDYGKAEAKFNRKMGHITVLCENPRDAAQSLEQTGCWDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-12-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTU2</accession>
    <name>B8DTU2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">5-nitroimidazole antibiotic resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29421">
        <property type="protein sequence ID" value="ACL29421"/>
        <property type="gene ID" value="BLA_1133"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1133"/>
    <dbReference type="HOGENOM" id="CLU_067890_1_0_11"/>
    <dbReference type="OMA" id="FEFTEKM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="183" mass="20562" checksum="077F81E4218DBD50" modified="2009-03-03" version="1">MHPSTPEKPSTTRPMRRADREVRSFEEIIDILRNCTEVRVAYQDAQGLTIVPVNFAFVYNNDDSSHNLRLLMHSATQGRKIEAIHASGNALPVAFEMDCDSLIYTGRTPCATSTAYRSIIGTGVASLLNDEHEKIDALKLLMKQRTDMHNVELLPRQVSKVAVWQIISTEFTAKAHPLPSDMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTU6</accession>
    <name>B8DTU6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218863.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29425">
        <property type="protein sequence ID" value="ACL29425"/>
        <property type="gene ID" value="BLA_1137"/>
    </dbReference>
    <dbReference type="GeneID" id="66532961"/>
    <dbReference type="KEGG" id="bla:BLA_1137"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1193"/>
    <dbReference type="HOGENOM" id="CLU_1746104_0_0_11"/>
    <dbReference type="OMA" id="VICITLM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="149" mass="16048" checksum="A104D3618E0F8576" modified="2009-03-03" version="1">MNKKSLAGPRALTIIGSLAMLVSLVLPYATSSNDTMTAFTIAERWKEMQSVANMSVGVSEIILVMIIAIAIFTVLALIFALAAKGIPTLVFVVLAILAYVYFNLSFTPYGSYGFGFGVYLFYVAAIAVIAGSIWMIAIKRHNKAAIPNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTY0</accession>
    <name>B8DTY0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BLA_1171</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218915.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1171"/>
    <dbReference type="EnsemblBacteria" id="ACL29459">
        <property type="protein sequence ID" value="ACL29459"/>
        <property type="gene ID" value="BLA_1171"/>
    </dbReference>
    <dbReference type="GeneID" id="66532996"/>
    <dbReference type="KEGG" id="bla:BLA_1171"/>
    <dbReference type="HOGENOM" id="CLU_009723_1_0_11"/>
    <dbReference type="OMA" id="GYTHRRI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="565"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="598"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="638"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="677"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="727"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="763"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="790"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="834" mass="90492" checksum="8E68A9AD97BAE8BA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTY2</accession>
    <name>B8DTY2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218917.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1173"/>
    <dbReference type="EnsemblBacteria" id="ACL29461">
        <property type="protein sequence ID" value="ACL29461"/>
        <property type="gene ID" value="BLA_1173"/>
    </dbReference>
    <dbReference type="GeneID" id="66532998"/>
    <dbReference type="KEGG" id="bla:BLA_1173"/>
    <dbReference type="HOGENOM" id="CLU_532838_0_0_11"/>
    <dbReference type="OMA" id="KETRYYQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="516" mass="55158" checksum="F4D0044515A41251" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTZ3</accession>
    <name>B8DTZ3_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ESAT-6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WXG100 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218164.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1184"/>
    <dbReference type="EnsemblBacteria" id="ACL29472">
        <property type="protein sequence ID" value="ACL29472"/>
        <property type="gene ID" value="BLA_1184"/>
    </dbReference>
    <dbReference type="GeneID" id="66533010"/>
    <dbReference type="KEGG" id="bla:BLA_1184"/>
    <dbReference type="HOGENOM" id="CLU_151185_6_0_11"/>
    <dbReference type="OMA" id="ITEWTIT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03930">
        <property type="entry name" value="WXG100_ESAT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="97" mass="10603" checksum="16FB8E1CECCA2B8C" modified="2009-03-03" version="1">MSQYQVDSERIAASSAAVCSSITAIRDAVTTMYANLNALQDAWRGAAAAQFNMVASEWRRTQQQMELSLEAMQQALTQASTVYADAEMQATRLFATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU05</accession>
    <name>B8DU05_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATPase involved in DNA repair</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218150.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1196"/>
    <dbReference type="EnsemblBacteria" id="ACL29484">
        <property type="protein sequence ID" value="ACL29484"/>
        <property type="gene ID" value="BLA_1196"/>
    </dbReference>
    <dbReference type="GeneID" id="66533021"/>
    <dbReference type="KEGG" id="bla:BLA_1196"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1258"/>
    <dbReference type="HOGENOM" id="CLU_024630_0_0_11"/>
    <dbReference type="OMA" id="DELWHRF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007139">
        <property type="entry name" value="DUF349"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03993">
        <property type="entry name" value="DUF349"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="394"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="472" mass="52338" checksum="E30C9D57A3E261E6" modified="2009-03-03" version="1">MADSNVTESKTTDNAVANDEATTPAAAVPSPAAMKAHAPSPAVLAKSPVAHLASSSSHDDVELKEAESFGRVDGNGTVYVKEGEEEREVGQFPDASADEALALYARRYLDLKAKLDVFANRLKSNSIKPREIDETLAALTEEVKQPAVVGDIPALQSQLEELRKKAAAKKDAIAKARKEAMTKAIAERTSIVEKAEALAAGLGDNTNWRSTADKFRSLFEQWQEHQRTTIRIDKAEADALWKRFSGARTTFNQARRKWAQARDAERSHAKAQKEAIIAEANEIKDSTAWGETSRKFNELMDRWKKAGRAGRNEDDALWAQFRAAADTFFNARQADREQISSNEKENLAQKEALLAKAEALVPVETGEQAKQARVKLAQIQEEWDQIGYVPREDMRRIEGRLDAVDNQIKAVEDAAWKKTDPEADARKSSFEGQLKAQLAELDEQIAKESDAKKKAKLEAEKATKEQWLNAIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU20</accession>
    <name>B8DU20_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218132.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1211"/>
    <dbReference type="EnsemblBacteria" id="ACL29499">
        <property type="protein sequence ID" value="ACL29499"/>
        <property type="gene ID" value="BLA_1211"/>
    </dbReference>
    <dbReference type="GeneID" id="66533035"/>
    <dbReference type="KEGG" id="bla:BLA_1211"/>
    <dbReference type="HOGENOM" id="CLU_123836_1_0_11"/>
    <dbReference type="OMA" id="GEWYAGV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010428">
        <property type="entry name" value="Zincin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038555">
        <property type="entry name" value="Zincin_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06262">
        <property type="entry name" value="Zincin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="122" mass="13848" checksum="1B2E46C55E16B683" modified="2009-03-03" version="1">MHMSEPEFERTVTEAVRSVPERFKKALSNIAITVADEPTDKEYVSMTHGDGELLGLYQGTPITQRTTGYAGVLPDRITIFKGPHERICATHAQMVEQIRKTVLHELGHYFGFDDKYLHSHGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU34</accession>
    <name>B8DU34_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ykoE</name>
        <name evidence="2" type="ordered locus">BLA_1225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218111.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1225"/>
    <dbReference type="EnsemblBacteria" id="ACL29513">
        <property type="protein sequence ID" value="ACL29513"/>
        <property type="gene ID" value="BLA_1225"/>
    </dbReference>
    <dbReference type="GeneID" id="66533049"/>
    <dbReference type="KEGG" id="bla:BLA_1225"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1287"/>
    <dbReference type="HOGENOM" id="CLU_089225_0_0_11"/>
    <dbReference type="OMA" id="GVIFWAW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017195">
        <property type="entry name" value="ABC_thiamin-permease_prd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09819">
        <property type="entry name" value="ABC_cobalt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037394">
        <property type="entry name" value="ABC_thiamine-permease_YkoE_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="202" mass="21659" checksum="D350C0D3796A9F17" modified="2009-03-03" version="1">MIYPSQASSRKWRVLDITVTSVIAVASGVVFWMWDWVCMAPLTLFENITPGFEGLLNGFWLFAGPLAAVIVRKPGAALYAETVAAFLELTLGNQWGVGGSLIVGLMQGLGAELAFALFAYKVWTNLVVLLSGALSGAMCGVYYWFTNPGWGMMRVSIYLGTSVVGGVIAAAACIALSRAIARTGALAQFAHWRVRDSEAKRA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU51</accession>
    <name>SYFA_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="1">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="1">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pheS</name>
        <name type="ordered locus">BLA_1242</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218088.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DU51"/>
    <dbReference type="SMR" id="B8DU51"/>
    <dbReference type="STRING" id="442563.BLA_1242"/>
    <dbReference type="EnsemblBacteria" id="ACL29530">
        <property type="protein sequence ID" value="ACL29530"/>
        <property type="gene ID" value="BLA_1242"/>
    </dbReference>
    <dbReference type="GeneID" id="66533064"/>
    <dbReference type="KEGG" id="bla:BLA_1242"/>
    <dbReference type="HOGENOM" id="CLU_025086_0_0_11"/>
    <dbReference type="OMA" id="DWHNFTA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00281">
        <property type="entry name" value="Phe_tRNA_synth_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004188">
        <property type="entry name" value="Phe-tRNA_ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022911">
        <property type="entry name" value="Phe_tRNA_ligase_alpha1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PTHR11538:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02912">
        <property type="entry name" value="Phe_tRNA-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000199299" description="Phenylalanine--tRNA ligase alpha subunit">
        <location>
            <begin position="1"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with beta subunit</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00281"/>
        </source>
    </evidence>
    <sequence length="355" mass="38721" checksum="FB277F3AF6E3DD0C" modified="2009-03-03" version="1">MAEGIVFDADAVSKDIAEGIAAIQQASTMEELKAIKAKYAGANSAMTRASKAIGSLAKNEKKEAGKVMGKLRADFGRAYGTKEASVKAAQEAAELAAETVDMTLPIRRKPLGARHPLPKLMEDVEDFFVGMGWQISDGPEVETEWFDFDALNFGPDHPARQMQDTFYVKGNQSKDAAGFVGSNMVLRTQTSSDQVRGLISHGVPLYIACPGRVFRTDELDATHTPVFHQVEALAVDKNLTMADLKGVLDKLAVAMFGPEAKSRLRPSYFPFTEPSAELDLWFPDKKGGPGWIEWGGCGMVNPNVLRSAGIDPDIYTGFAFGVGVERTLLLRHDINDMHDLVEGDVRFSEQFVMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU52</accession>
    <name>B8DU52_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="14">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="14">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 19" type="primary">pheT</name>
        <name evidence="19" type="ordered locus">BLA_1243</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="14"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1243"/>
    <dbReference type="EnsemblBacteria" id="ACL29531">
        <property type="protein sequence ID" value="ACL29531"/>
        <property type="gene ID" value="BLA_1243"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1243"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1306"/>
    <dbReference type="HOGENOM" id="CLU_016891_0_0_11"/>
    <dbReference type="OMA" id="ISYNWLK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02796">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00283">
        <property type="entry name" value="Phe_tRNA_synth_beta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004532">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033714">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="SSF54991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00472">
        <property type="entry name" value="pheT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14 19" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="16">
        <location>
            <begin position="39"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="B5" evidence="18">
        <location>
            <begin position="440"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="17">
        <location>
            <begin position="773"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="503"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ACL29531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="866" mass="94623" checksum="477BB34811ED4097" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU55</accession>
    <name>B8DU55_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="7">Glutamate N-acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">Ornithine acetyltransferase</fullName>
                <shortName evidence="7">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="7">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">N-acetylglutamate synthase</fullName>
                <shortName evidence="7">AGSase</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">argJ</name>
        <name evidence="8" type="ordered locus">BLA_1246</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Heterotetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ArgJ family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="7"/>
    <dbReference type="EC" id="2.3.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218081.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1246"/>
    <dbReference type="EnsemblBacteria" id="ACL29534">
        <property type="protein sequence ID" value="ACL29534"/>
        <property type="gene ID" value="BLA_1246"/>
    </dbReference>
    <dbReference type="GeneID" id="66533068"/>
    <dbReference type="KEGG" id="bla:BLA_1246"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1309"/>
    <dbReference type="HOGENOM" id="CLU_027172_2_0_11"/>
    <dbReference type="OMA" id="DYVHENS"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103045">
        <property type="term" value="F:methione N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="PTHR23100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5023436280" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="7">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023436281" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="7">
        <location>
            <begin position="183"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="7">
        <location>
            <begin position="182"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="390" mass="40355" checksum="A2E8365E77927A42" modified="2009-03-03" version="1">MSVTFAKGFEAAGVVAGISSQTGKQDVALVVNNGPLNAAAGVFTSNRFCAAPVQWSRKQVSDGELKAVILNSGGANACTGEEGYQQTVRTAEAVALMMHVEPSEIAVCSTGLIGELLPLDKVIEGAQKAFDSLDSSAQAGSDAAHAIMTTDTKPKTVNRLGSNEFRIGGMVKGSGMIAPQLATMLCVITTDAVVSAGQLQAALTAAVDRSFNRIDVDGCMSTNDTVLLLASGASGITPDPDEFNGLVADCCSSLARQIIGDGEGASHDIRIRVTGATSEDAALACGRAVAASNLLKCAISGNDPNWGRVVSSLGTVPADVAPYDPNEVSVTINGVRICANGGPDRDRSEVDMTLREIDIDIDLNAGESEACVWTDDLTHEYVHINADYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU66</accession>
    <name>B8DU66_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1257"/>
    <dbReference type="EnsemblBacteria" id="ACL29545">
        <property type="protein sequence ID" value="ACL29545"/>
        <property type="gene ID" value="BLA_1257"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1257"/>
    <dbReference type="HOGENOM" id="CLU_043473_1_0_11"/>
    <dbReference type="OMA" id="PPMHRET"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="346" mass="37018" checksum="02CEA798935CD6F9" modified="2009-03-03" version="1">MTLLKATEAPLSQTYSLALLDLDGVVYRGKDPVAFASESIRQAEHLGMTIEYTTNNSSRMQSVVADQLRGFGLDVEPWQVITSSVVAARMVSKHVPQGAKVLVVGAEHLQDEVGKAGLTPVQYASDHPTAVIQGWFPQMTWQMLAEASFAVENGAMYFVTNRDLTIPREAGIAPGCGSMIQAVINATGVQPIASAGKPESAMYDEARELAAQGDTEPVCKARSLAIGDRLDTDIEAGNRGGYDSLAVLTGVTNPTELMCAPKHLRPTYIVRDLRGLNEAYPRIDVDEAGTRATCAQAQASLTHRRLTVNDPNDVNALRAACALTWQAADSGQDVAAFALPEFSLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUB6</accession>
    <name>B8DUB6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29595">
        <property type="protein sequence ID" value="ACL29595"/>
        <property type="gene ID" value="BLA_1308"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1308"/>
    <dbReference type="HOGENOM" id="CLU_205074_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="49" mass="5415" checksum="796B757EDED57091" modified="2009-03-03" version="1">MSDMAQKIGELKGKAEVKADEVKMKAGELKGKAEAKLDELKKDHEDQSK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUC2</accession>
    <name>HIS2_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosyl-ATP pyrophosphatase</fullName>
            <shortName evidence="1">PRA-PH</shortName>
            <ecNumber evidence="1">3.6.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisE</name>
        <name type="ordered locus">BLA_1314</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PRA-PH family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.31" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217988.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DUC2"/>
    <dbReference type="SMR" id="B8DUC2"/>
    <dbReference type="STRING" id="442563.BLA_1314"/>
    <dbReference type="EnsemblBacteria" id="ACL29601">
        <property type="protein sequence ID" value="ACL29601"/>
        <property type="gene ID" value="BLA_1314"/>
    </dbReference>
    <dbReference type="GeneID" id="66533139"/>
    <dbReference type="KEGG" id="bla:BLA_1314"/>
    <dbReference type="HOGENOM" id="CLU_123337_2_1_11"/>
    <dbReference type="OMA" id="WMAAEYQ"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01020">
        <property type="entry name" value="HisE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000149047" description="Phosphoribosyl-ATP pyrophosphatase">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01020"/>
        </source>
    </evidence>
    <sequence length="87" mass="9768" checksum="569405820AAACE18" modified="2009-03-03" version="1">MKTFESLFAELSEKAANQTPGSLTVDELGKGTHFIGKKIIEEAGETWIAAEYEGAERTAEEMSQLIYHLQVMMIDRGITLDDIYKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUD3</accession>
    <name>B8DUD3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Probable hydrolase or phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217975.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1325"/>
    <dbReference type="EnsemblBacteria" id="ACL29612">
        <property type="protein sequence ID" value="ACL29612"/>
        <property type="gene ID" value="BLA_1325"/>
    </dbReference>
    <dbReference type="GeneID" id="66533150"/>
    <dbReference type="KEGG" id="bla:BLA_1325"/>
    <dbReference type="HOGENOM" id="CLU_045011_19_4_11"/>
    <dbReference type="OMA" id="YLCGKFG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="239" mass="26650" checksum="3064CE2B2C96371F" modified="2009-03-03" version="1">MTEPRRVVLLDLDGTLTESGPGIIKCVIKAFEAVDVPVPNDEALQRFIGPAIIDSMKLNGIPPQKLDEAVRVYRHFYGDANVFNDPNEPGRKVPGRLVNSMYEGIPEQLRKMREMGYYLAVCTAKPEYQAIPICEHFHLTDLVDGIYGASKDNSRITKEAVITYALDRIGVDRNAGDRALMVGDRWTDVDGAKLNGLDCLGCGWGYAEPNELREHGAYRVVPFVSELADAVNDYFTERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUE7</accession>
    <name>B8DUE7_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Holliday junction ATP-dependent DNA helicase RuvB</fullName>
            <ecNumber evidence="6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">ruvB</name>
        <name evidence="8" type="ordered locus">BLA_1341</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a complex with RuvA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="6"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217959.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1341"/>
    <dbReference type="EnsemblBacteria" id="ACL29626">
        <property type="protein sequence ID" value="ACL29626"/>
        <property type="gene ID" value="BLA_1341"/>
    </dbReference>
    <dbReference type="GeneID" id="66533166"/>
    <dbReference type="KEGG" id="bla:BLA_1341"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1403"/>
    <dbReference type="HOGENOM" id="CLU_055599_1_0_11"/>
    <dbReference type="OMA" id="IHRMSRP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00016">
        <property type="entry name" value="DNA_helic_RuvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041445">
        <property type="entry name" value="AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004605">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008824">
        <property type="entry name" value="RuvB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008823">
        <property type="entry name" value="RuvB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42848">
        <property type="entry name" value="PTHR42848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17864">
        <property type="entry name" value="AAA_lid_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05491">
        <property type="entry name" value="RuvB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05496">
        <property type="entry name" value="RuvB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00635">
        <property type="entry name" value="ruvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 6 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="AAA" evidence="7">
        <location>
            <begin position="65"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="73"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="355" mass="38709" checksum="043D98608FD6213E" modified="2009-03-03" version="1">MEYSGADNLDARDESLRMVSAVPVGNEPVSDEELRPHVLEGFIGQPRLKAQLQLFLDAARKRDVAPDHILMAGPPGLGKTTLAMIVANELGVPIRVTSGPAIQHAGDLASILSSLDVGEVLFIDEIHRLPRAAEELLYIAMEDFRVDVMVGKGPGASSIPLTLPRFTVIGATTREGMLPSPLRARFGFTAHLDFYPHEELEKLIERSASVLGLPLEDQAARQLSLRSRGTPRIANRLLRRVRDWAIVHDLDSVGADDVKDALALYQIDSEGLDRLDIAVLNAIVRQFNGGPVGLNNLSAMVGEEAETVETVCEPYLVREGFLIRTPKGRLATAKAWEHLGLKPDDGTPDDVSKLF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUE9</accession>
    <name>RUVC_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Crossover junction endodeoxyribonuclease RuvC</fullName>
            <ecNumber evidence="1">3.1.21.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Holliday junction nuclease RuvC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Holliday junction resolvase RuvC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ruvC</name>
        <name type="ordered locus">BLA_1343</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RuvC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217955.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DUE9"/>
    <dbReference type="SMR" id="B8DUE9"/>
    <dbReference type="STRING" id="442563.BLA_1343"/>
    <dbReference type="EnsemblBacteria" id="ACL29628">
        <property type="protein sequence ID" value="ACL29628"/>
        <property type="gene ID" value="BLA_1343"/>
    </dbReference>
    <dbReference type="GeneID" id="66533168"/>
    <dbReference type="KEGG" id="bla:BLA_1343"/>
    <dbReference type="HOGENOM" id="CLU_091257_0_2_11"/>
    <dbReference type="OMA" id="AICHIWR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16962">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00034">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020563">
        <property type="entry name" value="X-over_junc_endoDNase_Mg_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002176">
        <property type="entry name" value="X-over_junc_endoDNase_RuvC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30194">
        <property type="entry name" value="PTHR30194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02075">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00696">
        <property type="entry name" value="RSOLVASERUVC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00228">
        <property type="entry name" value="ruvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01321">
        <property type="entry name" value="RUVC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000195236" description="Crossover junction endodeoxyribonuclease RuvC">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="193" mass="20896" checksum="6184908DDC495777" modified="2009-03-03" version="1">MIVLGVDPGLTRCGVGVIEAGAYRRLSFIHVDVVRSDPHESQDLRLLKIYDGLCAKMDEFIPDTVSIERVFAQENRNTVLGTAQAAGMAMLAAAQRGIPVALHTPTESKMAITGNGKAEKIQMERMVARILNLNALPTPADAADALAIAICHALRPSGALEGGEREQHLTPAQRQWAQATQHATRRRGVRRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUG5</accession>
    <name>B8DUG5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1359"/>
    <dbReference type="EnsemblBacteria" id="ACL29644">
        <property type="protein sequence ID" value="ACL29644"/>
        <property type="gene ID" value="BLA_1359"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1359"/>
    <dbReference type="HOGENOM" id="CLU_033401_5_1_11"/>
    <dbReference type="OMA" id="GARFMDC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="253" mass="28276" checksum="941A2090F2C8FFA8" modified="2009-03-03" version="1">MQRAWRTSKRPAHVSRRSSNHCICRVNLWTLTMAAIRDTQPPRLPKFPMGGEGLIESRLSLLTAEDDQDSRRFFDQQASTIDMTAAALLNCEFRNLAIDTIIAERTHVNHVLVDSCRTALLGIRSIGMENSIAVHCSFGAVQANTAKIIGMEIRGCRIDYLNCRDAICRDIMFRDCEIGELDGNDAKFSRIAFAGTRIDVLSLQHAICADVDLRGARLREIRNVDSLHGTTMSLEQIADLSEVFARSIGIRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUJ4</accession>
    <name>B8DUJ4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MutT/nudix family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217895.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1388"/>
    <dbReference type="EnsemblBacteria" id="ACL29673">
        <property type="protein sequence ID" value="ACL29673"/>
        <property type="gene ID" value="BLA_1388"/>
    </dbReference>
    <dbReference type="GeneID" id="66533218"/>
    <dbReference type="KEGG" id="bla:BLA_1388"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1452"/>
    <dbReference type="HOGENOM" id="CLU_1538155_0_0_11"/>
    <dbReference type="OMA" id="FGEKHLT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="177" mass="20287" checksum="5BF6641F9191D0BE" modified="2009-03-03" version="1">MTEEPLSLELEDAEWPFEYIDHDRPIARAIVIDAHAYFYFLRVQRTDVFGNAVTIETSGGGIEPGETPTEAVMREVREELGAEIEILGEIGLVSDCYNRIHRHNINHYYLCQALSFGETNLTELERTRFNLSTLKLTYAQAIAEYRRCEDSKLGRLIAARELPMLERAWGMLGKLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUL3</accession>
    <name>B8DUL3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamate synthase (NADPH) small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gltD</name>
        <name evidence="7" type="ordered locus">BLA_1407</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217873.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1407"/>
    <dbReference type="EnsemblBacteria" id="ACL29692">
        <property type="protein sequence ID" value="ACL29692"/>
        <property type="gene ID" value="BLA_1407"/>
    </dbReference>
    <dbReference type="GeneID" id="66533236"/>
    <dbReference type="KEGG" id="bla:BLA_1407"/>
    <dbReference type="HOGENOM" id="CLU_000422_3_1_11"/>
    <dbReference type="OMA" id="DCVGTAH"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer4_20" evidence="6">
        <location>
            <begin position="39"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="147"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="511" mass="55918" checksum="EA9CA6F2DC28CBF4" modified="2009-03-03" version="1">MGDPRGFLKVRSRREPAERPVEERIKDWLDVHAESGLQDWTQEQAARCMDCGTPFCMSGCPLGNIIPEWNDLVRQGQWEDAYHRLSMTNNFPEVTGRICPALCESACVLGIHQPPTMIKNDEVTIIDQAWDLEYVKPLPPERLSDQTVAVVGSGPAGLACAQQLTRAGHTVVVFERDDEVGGLMRYGIPNFKLEKGLLDRRVKQMEAEGTRFRTNTEIGKDLGWDDLRSQFDAVVVAIGSTVPRDMSIPGRDLDGIHFAMEFLPDATRRVFGKQPIHDITAKDKHVVIIGGGDTGSDCLGTSIRQGAKDVTVLQIMPQEPTKRPDNQPWPTFARLYQKTSSMEEGGEYVYSTDSVNFVGSEEDAAKITVSDNTQTEGFISDGNGHVTGLKVVSVAPGKDGPFTRQPGTERVIPADLVLISVGFLHPDTETLQAQLPVDLDGRGNVARDDAFQTSQDGVFSCGDAGRGQSLVVWAIAEGRSCAAAVDRYLTGCTELPAPIVASERPMALPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUM7</accession>
    <name>B8DUM7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BLA_1421</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1421"/>
    <dbReference type="EnsemblBacteria" id="ACL29706">
        <property type="protein sequence ID" value="ACL29706"/>
        <property type="gene ID" value="BLA_1421"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1421"/>
    <dbReference type="HOGENOM" id="CLU_015237_4_2_11"/>
    <dbReference type="OMA" id="CAFFRIT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="216"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="283"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="418"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL29706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="454" mass="50236" checksum="8C25B38DB4B6487A" modified="2009-03-03" version="1">MVALVVVAIVLFWQSLLMASLESAIVRVTRANLNNLMIEAQTDSELSQFTRQKKIAKIHRVQHLVANRHATSSACAFLRILSNVLIGACVVCIAAIFASPVWLQLIYGVLAALVVAFVSVLARPRSVGSDKPLEILLAYSHLASFAYACAPFLHPRKSKSARKTELSENEELEEIHLEQGRAAINRVLETNRFDPEVSEMLHNVLALSDSLTREIMVPRTDMICIEKDDTLEDFLKLCSRSGYSRIPVIGNDIDDLLGIAYMKDAVRATIFNNAALSRPIESIMRKPMLVPELKPADDLFHEMQQTCHHVAVVVDEYGGIAGMVTIEDALEQIVGELQDEHDHTQHGEPRQIGEHKWSMPARTPIAELEDIFEIDLDEDDVDTVYGLLTKLLGRVPIVGSSAVTRGLRLTAVDSAGRRKKASTIVVEPESDVDQTTLESDADSPDSNSTKKEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUP2</accession>
    <name>B8DUP2_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="9">CTP synthetase</shortName>
            <shortName evidence="9">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">pyrG</name>
        <name evidence="12" type="ordered locus">BLA_1436</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014482910.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1436"/>
    <dbReference type="MEROPS" id="C26.964"/>
    <dbReference type="EnsemblBacteria" id="ACL29721">
        <property type="protein sequence ID" value="ACL29721"/>
        <property type="gene ID" value="BLA_1436"/>
    </dbReference>
    <dbReference type="GeneID" id="66533266"/>
    <dbReference type="KEGG" id="bla:BLA_1436"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1500"/>
    <dbReference type="HOGENOM" id="CLU_011675_5_0_11"/>
    <dbReference type="OMA" id="EFNNAYR"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="15"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="313"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="9">
        <location>
            <begin position="394"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="9">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="525"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="527"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="26"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="159"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="199"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACL29721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="561" mass="61916" checksum="181A910BF389EC47" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUQ3</accession>
    <name>B8DUQ3_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="6">Shikimate kinase</fullName>
                <shortName evidence="6">SK</shortName>
                <ecNumber evidence="6">2.7.1.71</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">3-dehydroquinate synthase</fullName>
                <shortName evidence="7">DHQS</shortName>
                <ecNumber evidence="7">4.2.3.4</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">aroB</name>
        <name evidence="6" type="synonym">aroK</name>
        <name evidence="10" type="ordered locus">BLA_1448</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).</text>
    </comment>
    <comment type="function">
        <text evidence="6">Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="6"/>
    <dbReference type="EC" id="4.2.3.4" evidence="7"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1448"/>
    <dbReference type="EnsemblBacteria" id="ACL29732">
        <property type="protein sequence ID" value="ACL29732"/>
        <property type="gene ID" value="BLA_1448"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1448"/>
    <dbReference type="HOGENOM" id="CLU_001201_5_2_11"/>
    <dbReference type="OMA" id="VSIWLRC"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00110">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0170">Cobalt</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DHQ_synthase" evidence="9">
        <location>
            <begin position="249"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="579"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="583"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="24"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="253"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="287"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="311"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="351"/>
            <end position="354"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL29732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="644" mass="70270" checksum="B304101C7BFEAF76" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUW6</accession>
    <name>B8DUW6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1513"/>
    <dbReference type="EnsemblBacteria" id="ACL29795">
        <property type="protein sequence ID" value="ACL29795"/>
        <property type="gene ID" value="BLA_1513"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1513"/>
    <dbReference type="HOGENOM" id="CLU_013148_3_1_11"/>
    <dbReference type="OMA" id="LYSGMAD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Glyco_hydro_127"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Glyco_hydro_127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="669" mass="75168" checksum="15C6CBD6B6BC237B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUY6</accession>
    <name>B8DUY6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP binding protein of ABC transporter for sugars</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">msiK</name>
        <name evidence="6" type="ordered locus">BLA_1533</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218984.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1533"/>
    <dbReference type="EnsemblBacteria" id="ACL29815">
        <property type="protein sequence ID" value="ACL29815"/>
        <property type="gene ID" value="BLA_1533"/>
    </dbReference>
    <dbReference type="GeneID" id="66533930"/>
    <dbReference type="KEGG" id="bla:BLA_1533"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_11"/>
    <dbReference type="OMA" id="PRNMYDK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="377" mass="41347" checksum="12B0DC8E0C4AFB9B" modified="2009-03-03" version="1">MAEVIFDHVTRIYPGNDKPSVDDLNLDIKDGEFLVLVGPSGCGKSTTLRMLAGLEEVNKGRILIGGKDVTTMQPKDRDIAMVFQNYALYPHMTVADNMGFALKIAGTPKDEIRKRVEKAAEILDLTEFLDRKPKALSGGQRQRVAMGRAIVREPKVFLMDEPLSNLDAKLRVQTRTQIAALQRQLGVTTLYVTHDQTEALTMGDRIAVIKLGILQQVGAPTELYDRPANVFVAGFIGSPSMNINTHPVVNGKAQIGADTMELPKEALDKLTPEDKNEIIVGFRPEDASLAAPDEANAFSLKVVNVEDLGSDGYIYGNIITDDSVAQKTTDTLMSDQNQLTTIRVNPRVLPKVGDVVKIKVNPAKMHLFSPSTELRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUZ9</accession>
    <name>B8DUZ9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ParB-like partition proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_1546</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219001.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1546"/>
    <dbReference type="EnsemblBacteria" id="ACL29828">
        <property type="protein sequence ID" value="ACL29828"/>
        <property type="gene ID" value="BLA_1546"/>
    </dbReference>
    <dbReference type="GeneID" id="66533944"/>
    <dbReference type="KEGG" id="bla:BLA_1546"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1625"/>
    <dbReference type="HOGENOM" id="CLU_023853_7_3_11"/>
    <dbReference type="OMA" id="MYELIMG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="4">
        <location>
            <begin position="184"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="462" mass="50920" checksum="797229319E66E721" modified="2009-03-03" version="1">MASKSRLGRGLGALFPTLPDEQEFQHEAQAAKPEPTKPEPAKKTTARKAAKKAPSKPSKAATEPKKAPYDPEAYADVDGPISPLSSTIPSMGAMTIHAETVNKLSAPMTLQPQAAEHHAAQQPDRPSSPVKTHGKRATMPAISSMTHHPSDMFFDGTPLADTAKPKEEESEAPELKPVAGGYLVELNPNQIGPNLYQPRTTFNEEELQELADSIKEVGVLQPIVVRKRPQEQIDEAKRRQSEEHAADRFAGRMDSEYELIMGERRWRASQLAGLTEIPVIVKTTSDEYMLRDALLENLHRVALNPLEEAAAYQQMIDEFGLTQKQLAQSVSKSRPQIANTLRLMNLPASVQKKVAAGQLSSGHARALLGLDTDEEMEQLAQRIIDEGLSVRSVEEIVSMSANKETRKPKTNRNNPWAGSPIQQHLSERFATKVSIKGSEQHGRIEIVFSSPEEMQRIIDLLG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV04</accession>
    <name>RNPA_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease P protein component</fullName>
            <shortName evidence="1">RNase P protein</shortName>
            <shortName evidence="1">RNaseP protein</shortName>
            <ecNumber evidence="1">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Protein C5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rnpA</name>
        <name type="ordered locus">BLA_1551</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RnpA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268877.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DV04"/>
    <dbReference type="SMR" id="B8DV04"/>
    <dbReference type="STRING" id="442563.BLA_1551"/>
    <dbReference type="EnsemblBacteria" id="ACL29833">
        <property type="protein sequence ID" value="ACL29833"/>
        <property type="gene ID" value="BLA_1551"/>
    </dbReference>
    <dbReference type="GeneID" id="66533949"/>
    <dbReference type="KEGG" id="bla:BLA_1551"/>
    <dbReference type="HOGENOM" id="CLU_117179_4_0_11"/>
    <dbReference type="OMA" id="THHVVIR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00227">
        <property type="entry name" value="RNase_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33992">
        <property type="entry name" value="PTHR33992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00188">
        <property type="entry name" value="rnpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_1000194608" description="Ribonuclease P protein component">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00227"/>
        </source>
    </evidence>
    <sequence length="118" mass="13309" checksum="9D480FE62EFE4974" modified="2009-03-03" version="1">MERLKNHREFVAVLKRRRRVSDADIVLHYVVRTPSTPTGAAPARRLGLAVSKSVGNAVVRNTVKRRFRVLAHRYEHELPADCDIVLRAKPGAAHASFQSLEAQIQALFRAVMRKSEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV31</accession>
    <name>B8DV31_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219062.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28332">
        <property type="protein sequence ID" value="ACL28332"/>
        <property type="gene ID" value="BLA_0027"/>
    </dbReference>
    <dbReference type="GeneID" id="66532404"/>
    <dbReference type="KEGG" id="bla:BLA_0027"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.27"/>
    <dbReference type="HOGENOM" id="CLU_820550_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="360" mass="40987" checksum="5FE99E5553CE3284" modified="2009-03-03" version="1">MAGKEKIDVRILRYTENGQKRYMAASCLLVLILSIVNAYVHEIEYMLRKKEYNYSWSELYNYFIDFYPNVNSPFSLLLELFSFLSTLAIALAVVVEGEGKMLILSKFSYWLCVGSCSVLAVMSRALFSGLGVIKAIAVIVSSIIILYYLGRFSIVIGQKNFINARMAFDKSVSLIYLKLYERYGGERSAARSLVKVFVLLSILLIMAIGPWVLLITDALSATRYDNGNILSVLLVFLFIYCLTFVALLKNEEHGMNGLLLVTSCFVPLLPLLFYVFHSIHNSIHYVIIFFIALSLSFWSLFCVACSRMSSGELSEKLRKRRPWILVAEIESIHSIKARLYMKIHLKYIDRVEYMNGLGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV36</accession>
    <name>B8DV36_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Viral A-type inclusion protein repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219068.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28337">
        <property type="protein sequence ID" value="ACL28337"/>
        <property type="gene ID" value="BLA_0032"/>
    </dbReference>
    <dbReference type="GeneID" id="66532409"/>
    <dbReference type="KEGG" id="bla:BLA_0032"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.32"/>
    <dbReference type="HOGENOM" id="CLU_388151_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="332"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="711" mass="80413" checksum="044135BADCD2BEAF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV68</accession>
    <name>B8DV68_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">glgP</name>
        <name evidence="11" type="ordered locus">BLA_0066</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218359.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0066"/>
    <dbReference type="CAZy" id="GT35">
        <property type="family name" value="Glycosyltransferase Family 35"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28369">
        <property type="protein sequence ID" value="ACL28369"/>
        <property type="gene ID" value="BLA_0066"/>
    </dbReference>
    <dbReference type="GeneID" id="66532442"/>
    <dbReference type="KEGG" id="bla:BLA_0066"/>
    <dbReference type="HOGENOM" id="CLU_010198_1_1_11"/>
    <dbReference type="OMA" id="KHKRTFT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="PTHR11468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 10 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL28369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="818" mass="92681" checksum="4C279851B00203BD" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV90</accession>
    <name>B8DV90_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BLA_0088</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0410 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28391">
        <property type="protein sequence ID" value="ACL28391"/>
        <property type="gene ID" value="BLA_0088"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0088"/>
    <dbReference type="HOGENOM" id="CLU_160040_4_0_11"/>
    <dbReference type="OMA" id="WIADMIV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007341">
        <property type="entry name" value="Transgly_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33884">
        <property type="entry name" value="PTHR33884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04226">
        <property type="entry name" value="Transgly_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="85" mass="8569" checksum="B83A9540AAF714F2" modified="2009-03-03" version="1">MDTMFWIWTLIVGAVIGAIAGAITNNGHSMGWISNILAGLAGSALGQGLFGSWGPSLGGMAVVPSVLGAVIVVAIVSFIVMKVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV96</accession>
    <name>B8DV96_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Queuine tRNA-ribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">tgt</name>
        <name evidence="7" type="ordered locus">BLA_0094</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:24104"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="EC" id="2.4.2.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.29" evidence="4"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218391.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0094"/>
    <dbReference type="EnsemblBacteria" id="ACL28397">
        <property type="protein sequence ID" value="ACL28397"/>
        <property type="gene ID" value="BLA_0094"/>
    </dbReference>
    <dbReference type="GeneID" id="66532470"/>
    <dbReference type="KEGG" id="bla:BLA_0094"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.100"/>
    <dbReference type="HOGENOM" id="CLU_022060_0_0_11"/>
    <dbReference type="OMA" id="GIDLFDC"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:queuine tRNA-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101030">
        <property type="term" value="P:tRNA-guanine transglycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGT" evidence="6">
        <location>
            <begin position="57"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="134"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="4">
        <location>
            <begin position="342"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL28397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="445" mass="49232" checksum="774D0F6AECAAFCFE" modified="2009-03-03" version="1">MTANTESIVQAPAPQLVEHPRGAEPGKPGDRSAFRFEQTTRLPDSPNGKGKGGARYGRTGILHTPHGDIKTPAFVPVATQGAMKAVLPESMTQLGAQCLLSNAFHLYERPGEDVLDEAGGLAKFMNWNGPTFTDSGGFQVLSLGAGFKKTLAMDVKGMKSDDVIAEGKERMAFVDEDGVTFKSPLNGSLHRFSAEISMNIQHKLGADIMFAFDELTTLMNTRRYQENSVERTYRWAQRCVAEHERLTQSRLGKPYQALYGVVQGANYEDLRRHAASQIASLDFDGVGIGGAMEKRIIGDICAWICDEMPESRPRHVLGIAAVDDIFACVENGGDTFDCVAPARCGRNGAIFTRDGRYNIKRAQYKHDFGPLEEGCQCYTCTHYTRAYVDHLLRAHEMNGFTLATIHNEYFFVHLLDDIRASIDGGYFDEFRDETLARFYANGSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVB1</accession>
    <name>B8DVB1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218407.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0109"/>
    <dbReference type="EnsemblBacteria" id="ACL28412">
        <property type="protein sequence ID" value="ACL28412"/>
        <property type="gene ID" value="BLA_0109"/>
    </dbReference>
    <dbReference type="GeneID" id="66532484"/>
    <dbReference type="KEGG" id="bla:BLA_0109"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_11"/>
    <dbReference type="OMA" id="AYDCIDV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="341" mass="37729" checksum="99B183A2A69C884E" modified="2009-03-03" version="1">MQYTTLGPSDLEVSRICLGCMSFGDAGNGQHSWTLDEESSRAIVQQALDAGINFLDTAIVYQNGTSEEYLGRALSSMAARDDVVVATKFLPRTDEEIENGVSGQQHVRDNLDMSLRHLGMDHVDLYIYHMWDWRTPIEEIMEGFANAVAAGKTRYIGAANIAAWQLEKANAIAREHGWPQFISVQNHMNLLFREDEREMLPCAQEEGIALTPYSSLASGRLSRRPGETSRRLREDSFAHGKYDAAAAMDADIIDEVRRIAEARGVTMTTVSLAWLLTKVTAPIIGATKPHHLDGAVAAVDFELSDSEIAALERPYQPHPIVGVMAQNTKENAAVAKSWERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVF7</accession>
    <name>B8DVF7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Possible MarR-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218469.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0156"/>
    <dbReference type="EnsemblBacteria" id="ACL28458">
        <property type="protein sequence ID" value="ACL28458"/>
        <property type="gene ID" value="BLA_0156"/>
    </dbReference>
    <dbReference type="GeneID" id="66532532"/>
    <dbReference type="KEGG" id="bla:BLA_0156"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.166"/>
    <dbReference type="HOGENOM" id="CLU_083287_12_1_11"/>
    <dbReference type="OMA" id="MQREFTR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="197" mass="22586" checksum="1D593BB5FD6AECC9" modified="2009-03-03" version="1">MDYQLEAVHELMFAMWASRSKATRSFERGAQGEMFVLRELSFQGARTPSQLAQAMGATSGRISSILASLTKKGWIVRTGDPQDRRSVVVELSDEGRRAVRQRSDRLIENLSWVFSQMGERRTREFVGLLSEFMTYLSICEPDGSYPTVEQVEEAFERRARLHERMREMVRNGEQWHGSCRPHDAPSSNDADVDRPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVI0</accession>
    <name>B8DVI0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrogen regulatory protein N-II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">glnB</name>
        <name evidence="4" type="ordered locus">BLA_0179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the P(II) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218496.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0179"/>
    <dbReference type="EnsemblBacteria" id="ACL28481">
        <property type="protein sequence ID" value="ACL28481"/>
        <property type="gene ID" value="BLA_0179"/>
    </dbReference>
    <dbReference type="GeneID" id="66532555"/>
    <dbReference type="KEGG" id="bla:BLA_0179"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.189"/>
    <dbReference type="HOGENOM" id="CLU_082268_0_0_11"/>
    <dbReference type="OMA" id="YRGTEHV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017918">
        <property type="entry name" value="N-reg_PII_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002332">
        <property type="entry name" value="N-reg_PII_urydylation_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115">
        <property type="entry name" value="PTHR30115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00638">
        <property type="entry name" value="PII_GLNB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00496">
        <property type="entry name" value="PII_GLNB_UMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="O-UMP-tyrosine" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602187-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="112" mass="11841" checksum="8E73DEEADB84CA3D" modified="2009-03-03" version="1">MKLITAIIQPHKLDDVKEALASAGVHGLTVSEANGYGRQRGHTEIYRGAEYTVDLIPKVRVEVLSDDADAETLVDVIVKSAGSGTIGDGKVWVAPLDMVVRVRTGETGSAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVI8</accession>
    <name>B8DVI8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218504.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0187"/>
    <dbReference type="EnsemblBacteria" id="ACL28489">
        <property type="protein sequence ID" value="ACL28489"/>
        <property type="gene ID" value="BLA_0187"/>
    </dbReference>
    <dbReference type="GeneID" id="66532563"/>
    <dbReference type="KEGG" id="bla:BLA_0187"/>
    <dbReference type="HOGENOM" id="CLU_030006_10_0_11"/>
    <dbReference type="OMA" id="ADQMIFE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="78"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="345" mass="37939" checksum="618AA617112A929E" modified="2009-03-03" version="1">MANALKKALIGGAVAAGLGVWAVAPRTFNNKRKNFVPTLPDVLYAHRGLHDAGSGLSQQHAGESGEYIALARRMALRAGYGSIDEPGPLAPENSLAAFAAAAEAGYGIELDVQLTLDNKAVVCHDPDLLRVAGDPRNIRDLTYDELVRIPLFPTAAPGAEVSPLLPGATENPPLVTTPSQAPAGYYQHVPLLEDVLRVVDGRVPIIVEFKFENYRTWDDRDEELMQTAAALLDAYQGLYVVESFNPAAMNWYKREHPDVCRGQLAEDTEFTKNPVLWMAGKLMFNEISRPDFVAYDFRNGNGAMLRFVRRMGAMAVAWTVRTSDELAGAQPYFDRFIFEAFVPKQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVI9</accession>
    <name>UPP_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="1">2.4.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">UMP pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UPRTase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">upp</name>
        <name type="ordered locus">BLA_0188</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Allosterically activated by GTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218505.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DVI9"/>
    <dbReference type="SMR" id="B8DVI9"/>
    <dbReference type="STRING" id="442563.BLA_0188"/>
    <dbReference type="EnsemblBacteria" id="ACL28490">
        <property type="protein sequence ID" value="ACL28490"/>
        <property type="gene ID" value="BLA_0188"/>
    </dbReference>
    <dbReference type="GeneID" id="66532564"/>
    <dbReference type="KEGG" id="bla:BLA_0188"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.198"/>
    <dbReference type="HOGENOM" id="CLU_067096_2_3_11"/>
    <dbReference type="OMA" id="TYATRMP"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006223">
        <property type="term" value="P:uracil salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01218_B">
        <property type="entry name" value="Upp_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034332">
        <property type="entry name" value="Upp_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005765">
        <property type="entry name" value="Ura_phspho_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01091">
        <property type="entry name" value="upp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0021">Allosteric enzyme</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000164811" description="Uracil phosphoribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="131"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>uracil</name>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="202"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>uracil</name>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01218"/>
        </source>
    </evidence>
    <sequence length="213" mass="23365" checksum="5475715835A96914" modified="2009-03-03" version="1">MELHVLNHPLIEHKLTVLRDKNTPSSTFRELVSELVSLEAYEATRNLEVVDKPIETPVAPMVGKQIAKPRPIIVPVLRAGLGMLDGMTRMMPSAEVGFLGMKRDEEHPTQQITYANRLPDDLSGRQCFLIDPMLATGGTLVTATHYLMDKGAKDVTAICIIAAPEGIKFVEENIREDINFRVVVCGVDEGLNGKSYIVPGLGDAGDRLYGVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVJ8</accession>
    <name>B8DVJ8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Type II secretion system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BLA_0197</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0197"/>
    <dbReference type="EnsemblBacteria" id="ACL28499">
        <property type="protein sequence ID" value="ACL28499"/>
        <property type="gene ID" value="BLA_0197"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0197"/>
    <dbReference type="HOGENOM" id="CLU_064089_2_1_11"/>
    <dbReference type="OMA" id="WIEAWSA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="71"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="209" mass="22319" checksum="B1AF5E9928CE65C4" modified="2009-03-03" version="1">MAGFWAWCAAICAALASYLHMVGNERIAARRLRELDGLARSQIALAGRGNALQRRLLEVCPGWEPSPTLLLQLLEAAIAQGVAIPRALECIGACCGGACAQVLGHVSAALLRGVCWDEAWAVLEHDGSSPASSALGLACRTLRAAWEDGVSPLPQIHAAIEQMDGSERARIEQRASRLSVRLLLPMGLCLLPAFLLIAVVPTIMSFMRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVK2</accession>
    <name>B8DVK2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA polymerase III, subunits gamma and tau</fullName>
            <ecNumber evidence="6">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaX</name>
        <name evidence="6" type="ordered locus">BLA_0201</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DnaX/STICHEL family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="6"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218518.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0201"/>
    <dbReference type="EnsemblBacteria" id="ACL28503">
        <property type="protein sequence ID" value="ACL28503"/>
        <property type="gene ID" value="BLA_0201"/>
    </dbReference>
    <dbReference type="GeneID" id="66532575"/>
    <dbReference type="KEGG" id="bla:BLA_0201"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.212"/>
    <dbReference type="HOGENOM" id="CLU_006229_5_1_11"/>
    <dbReference type="OMA" id="DDPWNQP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18137">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022754">
        <property type="entry name" value="DNA_pol_III_gamma-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012763">
        <property type="entry name" value="DNA_pol_III_sug/sutau_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045085">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12169">
        <property type="entry name" value="DNA_pol3_gamma3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02397">
        <property type="entry name" value="dnaX_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="5">
        <location>
            <begin position="36"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="382"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="595"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="769"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="831"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="411"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="595"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="664"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL28503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="850" mass="91096" checksum="25D031164AC375FD" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVK8</accession>
    <name>B8DVK8_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="3">2.3.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Alpha-IPM synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Alpha-isopropylmalate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">leuA</name>
        <name evidence="5" type="ordered locus">BLA_0207</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218524.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0207"/>
    <dbReference type="EnsemblBacteria" id="ACL28509">
        <property type="protein sequence ID" value="ACL28509"/>
        <property type="gene ID" value="BLA_0207"/>
    </dbReference>
    <dbReference type="GeneID" id="66532581"/>
    <dbReference type="KEGG" id="bla:BLA_0207"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.219"/>
    <dbReference type="HOGENOM" id="CLU_004588_3_2_11"/>
    <dbReference type="OMA" id="WPDKVID"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="4">
        <location>
            <begin position="72"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="637" mass="70261" checksum="6FE81D4757613E49" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVM1</accession>
    <name>B8DVM1_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF559 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219300.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0220"/>
    <dbReference type="EnsemblBacteria" id="ACL28522">
        <property type="protein sequence ID" value="ACL28522"/>
        <property type="gene ID" value="BLA_0220"/>
    </dbReference>
    <dbReference type="GeneID" id="66532594"/>
    <dbReference type="KEGG" id="bla:BLA_0220"/>
    <dbReference type="HOGENOM" id="CLU_052626_2_1_11"/>
    <dbReference type="OMA" id="MVARCTE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007569">
        <property type="entry name" value="DUF559"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04480">
        <property type="entry name" value="DUF559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF559" evidence="1">
        <location>
            <begin position="231"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="340" mass="39230" checksum="7B7B8406E7D096F6" modified="2009-03-03" version="1">MITNEINKKPHGMMADVEQTQIRMSGRCSAFLNERKMDATFGLLTALELLGITTPWLRAAYSRWEKDRYLQIIADSRGMRYAEKHRYGVAYYTMNVPIHRVEVSPGIYCTDPVCTWFMMARFVSLDYLVALGDAILGPNNRLSELGLHYELEDFISYIEEVEQWTADPSHSRKRAPRGIGECRLAIELMRQRVESPQESIVRIDVLMKHGLPEPKINYVVNLENGHTARLDMAYPQWKIAIEYDGKQHEESWEEDNLRRNKLAELGWAIIVVTRADVATPEAQLACAYRIAARIEERTHEPMPVFADGYTTEELAMVVSGKPVRPRKWRRKRGMGKREVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVR8</accession>
    <name>B8DVR8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted metal-binding, possibly nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268381.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0267"/>
    <dbReference type="EnsemblBacteria" id="ACL28569">
        <property type="protein sequence ID" value="ACL28569"/>
        <property type="gene ID" value="BLA_0267"/>
    </dbReference>
    <dbReference type="GeneID" id="66532642"/>
    <dbReference type="KEGG" id="bla:BLA_0267"/>
    <dbReference type="HOGENOM" id="CLU_100236_0_0_11"/>
    <dbReference type="OMA" id="RLDHRNP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003772">
        <property type="entry name" value="YceD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02620">
        <property type="entry name" value="YceD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="198" mass="21532" checksum="C8D7C13BC30F18F5" modified="2009-03-03" version="1">MARIEYTDWTVPVAQVGSRAGQTMQVDRDFPAPGGIGDSIVGVKEGEPIHVNGQFDSIIDGLIFTGTFTAPVTAVCARCDRDLSGDWSEQVTAFFPYEDADAGKTKNEDVEIIAGEEESGDTYPLIDNGAFANIEPLLRDTFVSALPLNPLCKPDCKGLCPQCGLDLNESPEHVHEVTDLRFADLEALKEQLEREQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVS9</accession>
    <name>B8DVS9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mannose-1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.22</ecNumber>
            <ecNumber evidence="3">5.3.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.22" evidence="3"/>
    <dbReference type="EC" id="5.3.1.8" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268403.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0278"/>
    <dbReference type="EnsemblBacteria" id="ACL28580">
        <property type="protein sequence ID" value="ACL28580"/>
        <property type="gene ID" value="BLA_0278"/>
    </dbReference>
    <dbReference type="GeneID" id="66532655"/>
    <dbReference type="KEGG" id="bla:BLA_0278"/>
    <dbReference type="HOGENOM" id="CLU_035527_0_1_11"/>
    <dbReference type="OMA" id="LIVCNEK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008928">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GDP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005976">
        <property type="term" value="P:polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001538">
        <property type="entry name" value="Man6P_isomerase-2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01050">
        <property type="entry name" value="MannoseP_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="MannoseP_isomer" evidence="2">
        <location>
            <begin position="362"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="403" mass="43561" checksum="DBB6778C6B82B7DE" modified="2009-03-03" version="1">MSNGFDDFYAIIPAGGTGTRLWPLSREAKPKFLFDLLGSGRTLIQSTFDRLAAIAGMDHVCISTGERHVDAVEEQMPEVAPEHIFAEPAPRDSTAAIALATAVLARRHGNDIVVGSFAADHVIRGKVAFVDAVRQAVATARAGYVTTIGIAASRPSTAFGYIHEGESLAARVPDAPDAVLVERFVEKPNAATAQAYLNTGEYRWNAGMFVMRADVLLDHLHRVKPQLARAIDAIADAVIEDDRDLARAQAEAHERGENVRETVNPDDFHAHRDEAMRKYWQGIEKIAFDYAVAEPLSVEGGVAMIPGDFGWDDIGDFNSVAALLPSVDERNLKILGNTEQVVTLDSAGDIVVPNSERTVALLGVNDMVVVDTPDALLITPRARSQEVKSMVKTLAESGCDELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVT8</accession>
    <name>B8DVT8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribonuclease G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rne</name>
        <name evidence="8" type="ordered locus">BLA_0287</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268419.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0287"/>
    <dbReference type="EnsemblBacteria" id="ACL28589">
        <property type="protein sequence ID" value="ACL28589"/>
        <property type="gene ID" value="BLA_0287"/>
    </dbReference>
    <dbReference type="GeneID" id="66532664"/>
    <dbReference type="KEGG" id="bla:BLA_0287"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.305"/>
    <dbReference type="HOGENOM" id="CLU_003468_2_2_11"/>
    <dbReference type="OMA" id="YLDTMAP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019307">
        <property type="entry name" value="RNA-bd_AU-1/RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004659">
        <property type="entry name" value="RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30001">
        <property type="entry name" value="PTHR30001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10150">
        <property type="entry name" value="RNase_E_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00757">
        <property type="entry name" value="RNaseEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="514"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="981"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1006"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="368"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="1028" mass="115257" checksum="045E0D6DA7B43DE3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVV0</accession>
    <name>B8DVV0_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_0299</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BioY family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0299"/>
    <dbReference type="EnsemblBacteria" id="ACL28601">
        <property type="protein sequence ID" value="ACL28601"/>
        <property type="gene ID" value="BLA_0299"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0299"/>
    <dbReference type="HOGENOM" id="CLU_077931_1_1_11"/>
    <dbReference type="OMA" id="AGYLWSY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003784">
        <property type="entry name" value="BioY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34295">
        <property type="entry name" value="PTHR34295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02632">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016661">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870928" description="Biotin transporter" evidence="4">
        <location>
            <begin position="35"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR016661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="205" mass="20733" checksum="69C60CFB689184F8" modified="2009-03-03" version="1">MHSVTRVNLRSLVRTLAPSLIVALLLCGSTMAGKIPVPGTPVPITLQTFVLMTAALTLGWRRATAGTVLYLGLGAAGLPVFSGGGSTLSLIGPSGGFLFGFVPSVMLTAVLAGTANRAITSLRTKHDMHPALAGAARFIACFMACAFGFLIAGYGFGAAFQSTVTGMPLGITAASTLVFVPGDLIKIAVASLLALPVLASADSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVV5</accession>
    <name>B8DVV5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein involved in the export of O-antigen and teichoic acid</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268460.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0304"/>
    <dbReference type="EnsemblBacteria" id="ACL28606">
        <property type="protein sequence ID" value="ACL28606"/>
        <property type="gene ID" value="BLA_0304"/>
    </dbReference>
    <dbReference type="GeneID" id="66532683"/>
    <dbReference type="KEGG" id="bla:BLA_0304"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.326"/>
    <dbReference type="HOGENOM" id="CLU_083547_0_0_11"/>
    <dbReference type="OMA" id="PYWIGRT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="236" mass="25771" checksum="3954369824AB82C9" modified="2009-03-03" version="1">MPDSEQQEIARLRSEPAATPTTPSSAGVMAQNIVSKHPEATIPESDISLADIERKQSNPVKWTVSIVLVLAALIAPFWVGRSFAVHSTARVIEQLGHFTSYGIALVSWGVTTMIFVSLIMMIVDNRRMAWFGSFIVFLSLEQFIGGLSLFKLNFWSSTYVIYGSHAYVANAANLGVIASALALAVFAIVWVGLLVMIRKDSPLNVLTHVWVSFIMFLVFELAALAILFCGGFMAVA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVV8</accession>
    <name>PNP_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Polynucleotide phosphorylase</fullName>
            <shortName evidence="1">PNPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pnp</name>
        <name type="ordered locus">BLA_0307</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)</text>
            <dbReference type="Rhea" id="RHEA:22096"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268467.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DVV8"/>
    <dbReference type="SMR" id="B8DVV8"/>
    <dbReference type="STRING" id="442563.BLA_0307"/>
    <dbReference type="EnsemblBacteria" id="ACL28609">
        <property type="protein sequence ID" value="ACL28609"/>
        <property type="gene ID" value="BLA_0307"/>
    </dbReference>
    <dbReference type="GeneID" id="66532686"/>
    <dbReference type="KEGG" id="bla:BLA_0307"/>
    <dbReference type="HOGENOM" id="CLU_004217_2_2_11"/>
    <dbReference type="OMA" id="LHILDVM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01595">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014069">
        <property type="entry name" value="GPSI/PNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015848">
        <property type="entry name" value="PNPase_PH_RNA-bd_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036456">
        <property type="entry name" value="PNPase_PH_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="PTHR11252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03726">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46915">
        <property type="entry name" value="SSF46915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03591">
        <property type="entry name" value="polynuc_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02696">
        <property type="entry name" value="pppGpp_PNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000185723" description="Polyribonucleotide nucleotidyltransferase">
        <location>
            <begin position="1"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="587"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="658"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="727"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="739"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="521"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="873" mass="97727" checksum="7C8231CD6473C758" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVW1</accession>
    <name>B8DVW1_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonucleoside-diphosphate reductase subunit beta</fullName>
            <ecNumber evidence="4">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nrdF</name>
        <name evidence="7" type="ordered locus">BLA_0310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 6">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="4 6">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268473.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0310"/>
    <dbReference type="EnsemblBacteria" id="ACL28612">
        <property type="protein sequence ID" value="ACL28612"/>
        <property type="gene ID" value="BLA_0310"/>
    </dbReference>
    <dbReference type="GeneID" id="66532689"/>
    <dbReference type="KEGG" id="bla:BLA_0310"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.332"/>
    <dbReference type="HOGENOM" id="CLU_052495_0_0_11"/>
    <dbReference type="OMA" id="IGYKYQR"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026494">
        <property type="entry name" value="RNR_NrdF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="PTHR23409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000355">
        <property type="entry name" value="NrdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04171">
        <property type="entry name" value="RNR_1b_NrdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL28612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="321" mass="36742" checksum="9D211CEBDD4DA8A3" modified="2009-03-03" version="1">MPKLIDRVTAINWNRLDDEKDLEVWDRLTGNFWLPEKVPVSNDIPDWRQMSDAEHTLTMRVFTGLTLLDTIQGTVGAVSLIPDALTPHEEAVYTNIAFMESVHAKSYSSIFSTLCSTREIDEAFDWSEKNPHLQRKAQIVLDYYEGDDPLKRKVASTLLESFLFYSGFYLPMYFSSHAKLTNTADVIRLIIRDEAVHGYYIGYKYQKGLEMASDAKRAEMETYTYDLLNELYENEVEYTHSLYDEVGLSDDVEKFLHYNANKALMNLGYPALFPSEICDVNPAILAALSPNADENHDFFSGSGSSYVMGRAEETDDDDWDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVW6</accession>
    <name>B8DVW6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Possible protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268481.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0315"/>
    <dbReference type="EnsemblBacteria" id="ACL28617">
        <property type="protein sequence ID" value="ACL28617"/>
        <property type="gene ID" value="BLA_0315"/>
    </dbReference>
    <dbReference type="GeneID" id="66532694"/>
    <dbReference type="KEGG" id="bla:BLA_0315"/>
    <dbReference type="HOGENOM" id="CLU_011540_0_2_11"/>
    <dbReference type="OMA" id="MREYVGQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001539">
        <property type="entry name" value="Peptidase_U32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032525">
        <property type="entry name" value="Peptidase_U32_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01136">
        <property type="entry name" value="Peptidase_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16325">
        <property type="entry name" value="Peptidase_U32_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01276">
        <property type="entry name" value="PEPTIDASE_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_U32_C" evidence="2">
        <location>
            <begin position="415"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="511" mass="56668" checksum="FBB9CCB2EFE69ADF" modified="2009-03-03" version="1">MKRRGKPEVLAPAGNLRGLKTAVDYGADAVYCGGKSFGMRSAPRNLSLDDFREGAAYAHERGARVYVTLNILPRNNEITAIERYIEDLRTTGVDALIVTDIGVMMLAHRIAPELELHVSTQAGVTNYLAANALHDLGARRVVLAREMDLQAVRDIRANIPDDLDIETFVHGSMCMAFSGRCLISNYLTGRDGNHGECAQPCRWKYSLVEEKRPGQVFPVEETAQGTYLFNSQDMNMMAHLDDLIDSGATSLKIEGRSKSAYYVAAMTNAYKTAVNEYMVQRGFEDEAGNELKPFHDRVVRAGEEGFADSARDTIMLNADAAFAGMPNWDSANDEGEAGGISNRQARRTGLKRQGQLVEESDDGWRHAPVRPAPHVELPQWLMEEPYKVAHRDYSTGFYYPEQKVTQNTDRSAYFRDWLVVGEVLSWSPEEGGRVTIMSRNKMEPGQLVEFLLPGRAPLEYVVPDGGIRDADGNEVPMVNNPAHVFSLPLGVEVPVNAALRSRTKKPTLKAE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVZ4</accession>
    <name>CH10_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Chaperonin-10</fullName>
            <shortName evidence="1">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">groES</name>
        <name evidence="1" type="synonym">groS</name>
        <name type="ordered locus">BLA_0343</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268536.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DVZ4"/>
    <dbReference type="SMR" id="B8DVZ4"/>
    <dbReference type="STRING" id="442563.BLA_0343"/>
    <dbReference type="EnsemblBacteria" id="ACL28645">
        <property type="protein sequence ID" value="ACL28645"/>
        <property type="gene ID" value="BLA_0343"/>
    </dbReference>
    <dbReference type="GeneID" id="66532722"/>
    <dbReference type="KEGG" id="bla:BLA_0343"/>
    <dbReference type="HOGENOM" id="CLU_132825_2_0_11"/>
    <dbReference type="OMA" id="EVKYSGE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000146888" description="Co-chaperonin GroES">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="98" mass="10711" checksum="5B9346C161A95663" modified="2009-03-03" version="1">MSFPLTPLEDKIIVKQAEAETQTASGLIIPDNAKEKPQQGEVLAVGPGRRDDEGKRVPMDVKVGDKVLYSKYGGTEVHFKGEEYLIVSARDLLAVVND</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW05</accession>
    <name>RL13_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplM</name>
        <name type="ordered locus">BLA_0354</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268555.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DW05"/>
    <dbReference type="SMR" id="B8DW05"/>
    <dbReference type="STRING" id="442563.BLA_0354"/>
    <dbReference type="EnsemblBacteria" id="ACL28656">
        <property type="protein sequence ID" value="ACL28656"/>
        <property type="gene ID" value="BLA_0354"/>
    </dbReference>
    <dbReference type="GeneID" id="66532737"/>
    <dbReference type="KEGG" id="bla:BLA_0354"/>
    <dbReference type="HOGENOM" id="CLU_082184_2_1_11"/>
    <dbReference type="OMA" id="DFVVIIN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_L13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000166851" description="50S ribosomal protein L13">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <sequence length="149" mass="16651" checksum="C36DC8BE0A52F2A7" modified="2009-03-03" version="1">MKTFTPKPADLTHDWYIIDAKDVVLGRLSVAAANLLRGKNKPSFAPHADSGNYVIIINADKIALTGDKMDKELYSHSGRPGGLRRDSYAELLKNKPERIIMHAVKGMLPKNKLAKVQLTRLRVFAGEEHPHVGQNPQVYEIEQISQQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW13</accession>
    <name>B8DW13_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rplC</name>
        <name evidence="8" type="ordered locus">BLA_0362</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268572.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0362"/>
    <dbReference type="EnsemblBacteria" id="ACL28664">
        <property type="protein sequence ID" value="ACL28664"/>
        <property type="gene ID" value="BLA_0362"/>
    </dbReference>
    <dbReference type="GeneID" id="66532745"/>
    <dbReference type="KEGG" id="bla:BLA_0362"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.389"/>
    <dbReference type="HOGENOM" id="CLU_044142_4_1_11"/>
    <dbReference type="OMA" id="KRMAGRY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_L3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_L3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="PTHR11229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="216" mass="23209" checksum="353DBCE876919ADE" modified="2009-03-03" version="1">MSQNKNRNALLGKKLGMSQVWDENGFFVPVTLVEVSTNVVTAVKNEETDGYKAVQLGYGQVDPRKVTKPMAGHFAKAGVTPRRHLAEVRTENVEDFEPGQELTAEVFPEGVQVDVTGTTKGKGFAGTIKRWGFKSYRRTHGSHKNERRPGSVGACATPSRILKGKRMAGRMGHVTNTVQNLTVVSSDVENGILAIKGAIPGPKGGIVLVRSAVKGA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW15</accession>
    <name>RL23_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplW</name>
        <name type="ordered locus">BLA_0364</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268576.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DW15"/>
    <dbReference type="SMR" id="B8DW15"/>
    <dbReference type="STRING" id="442563.BLA_0364"/>
    <dbReference type="EnsemblBacteria" id="ACL28666">
        <property type="protein sequence ID" value="ACL28666"/>
        <property type="gene ID" value="BLA_0364"/>
    </dbReference>
    <dbReference type="GeneID" id="66532747"/>
    <dbReference type="KEGG" id="bla:BLA_0364"/>
    <dbReference type="HOGENOM" id="CLU_037562_3_2_11"/>
    <dbReference type="OMA" id="FEVDHRA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000184066" description="50S ribosomal protein L23">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <sequence length="98" mass="10911" checksum="8BA8338A3C87B6DE" modified="2009-03-03" version="1">MVAIHKPAHDIILKPVVSEKSYALSDMGQYTFVVAPNANKVQIKQAIEEIFKVKVTNVNTLNRAGKRTRTRTGYGRRVNQKRAIVTVAEGQSIDIFGN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW20</accession>
    <name>RL16_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplP</name>
        <name type="ordered locus">BLA_0369</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268585.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DW20"/>
    <dbReference type="SMR" id="B8DW20"/>
    <dbReference type="STRING" id="442563.BLA_0369"/>
    <dbReference type="EnsemblBacteria" id="ACL28671">
        <property type="protein sequence ID" value="ACL28671"/>
        <property type="gene ID" value="BLA_0369"/>
    </dbReference>
    <dbReference type="GeneID" id="66532752"/>
    <dbReference type="KEGG" id="bla:BLA_0369"/>
    <dbReference type="HOGENOM" id="CLU_078858_2_1_11"/>
    <dbReference type="OMA" id="KGAVEYW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01342">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_L16_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="PTHR12220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_1000166337" description="50S ribosomal protein L16">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="139" mass="15636" checksum="2E839593FC2A411E" modified="2009-03-03" version="1">MLIPKRTKYRKQHRPDRHGMSKGGNEINFGDFAIQALAPAYVTNRQIEAARIAMTRYIKRGGKVWITIFPDRPLTKHPLGARMGSGKGTPEFWIANVHPGRVMFEIGGVSEDVAREALRRAIDKLPMKCRVIAREGGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW48</accession>
    <name>B8DW48_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0397</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0397"/>
    <dbReference type="EnsemblBacteria" id="ACL28699">
        <property type="protein sequence ID" value="ACL28699"/>
        <property type="gene ID" value="BLA_0397"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0397"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.425"/>
    <dbReference type="HOGENOM" id="CLU_086032_0_0_11"/>
    <dbReference type="OMA" id="WPGWALN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="226" mass="24076" checksum="4C0CAE860B45E430" modified="2009-03-03" version="1">MANNSGSKGPSNAGRRTSQSGARRQPQPTQTSAVHSLRYVRIVVAVFVMLFVLALVSAFGWPGWAVRTPAKPVAVPTATPSKATVKAKALPGDATALLRAMPDHVSNFARVQADSTDAWADSNPIEEYKLTYSNGNDKDAVQLTVAQWSDSEKAQGQYTKLTGDLKGSSLANGVVKVNGDVTGNYEVKTAESDDTQATAVWRNDTVVFSVTGTKNSVVSVYQLFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW82</accession>
    <name>B8DW82_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UspA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268717.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0432"/>
    <dbReference type="EnsemblBacteria" id="ACL28733">
        <property type="protein sequence ID" value="ACL28733"/>
        <property type="gene ID" value="BLA_0432"/>
    </dbReference>
    <dbReference type="GeneID" id="66532817"/>
    <dbReference type="KEGG" id="bla:BLA_0432"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.461"/>
    <dbReference type="HOGENOM" id="CLU_049301_2_3_11"/>
    <dbReference type="OMA" id="LPAHAKC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="3">
        <location>
            <begin position="5"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="3">
        <location>
            <begin position="159"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="351" mass="37965" checksum="B2115E6CB1D22BFB" modified="2009-03-03" version="1">MNDNTILVGVDGSHASYKATWWAANYAKHMGLSLQIVCAYSLPSYAAVSFDATYTSMGDDNAAHNDAQEILSKAKAIADEQGVNAQTLIVTGDPSSVFVELSRNYNLIVIGNRGKGGLAERLLGTTSSSLPAYAYCPIVVVPYTDDKDNLLHLNNVITKVAVGSDDTKWGLRALQIAADFAANWGAELDVITVVPGNTNLDDPAQKQKFEDVLDARLESICTTHPDLKIRKSIVAGRAVETLTKASHTHDIVVVGSCGRGGLTGLLFNSTSQGLLQHSASPVYVVPRKFVEAEEQRVKTGTASGTETAEVTSLEEFVREVPVERASEETERQIEIDIDPKAHEYRQDDNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW93</accession>
    <name>B8DW93_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268740.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28744">
        <property type="protein sequence ID" value="ACL28744"/>
        <property type="gene ID" value="BLA_0443"/>
    </dbReference>
    <dbReference type="GeneID" id="66532829"/>
    <dbReference type="KEGG" id="bla:BLA_0443"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.474"/>
    <dbReference type="HOGENOM" id="CLU_141478_0_0_11"/>
    <dbReference type="OMA" id="PRIASMF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870531" evidence="2">
        <location>
            <begin position="34"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="120" mass="12387" checksum="78066B2D602F43C7" modified="2009-03-03" version="1">MVSRTIGTRCRSLLAAVGALTLCVALGACGARHDERAAEGRSQVAPSPTPSQTAQERTRGTDSLLSADLIEQIRQLDGNSDPQTTRSVFAGILFNGPGHESPGGPGRGATPDATRTSRCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWC4</accession>
    <name>B8DWC4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Permeases of the major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268802.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0476"/>
    <dbReference type="EnsemblBacteria" id="ACL28775">
        <property type="protein sequence ID" value="ACL28775"/>
        <property type="gene ID" value="BLA_0476"/>
    </dbReference>
    <dbReference type="GeneID" id="66532861"/>
    <dbReference type="KEGG" id="bla:BLA_0476"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.505"/>
    <dbReference type="HOGENOM" id="CLU_123281_0_2_11"/>
    <dbReference type="OMA" id="CIADMII"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021517">
        <property type="entry name" value="DUF3180"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11377">
        <property type="entry name" value="DUF3180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="205" mass="22724" checksum="005235019217F1FF" modified="2009-03-03" version="1">MKARRTPWWWYVIAMLVGLLAGMGISHLEETRGLGLAGIPYLASAVMVVVGFIVLYLAWQVHKYTTTDPKKRAQLKPMDSERCVNTLIVSKALAIAGALLAGWYGGQIVMLYDRFEAPFFRHIVIECIIAVIASVIDMVLGIISEGLCQLPPNMGPEHPKVVRKRREERLARFTNRASGLPMQAAGHHAGNNGADESDKWEKPCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWF6</accession>
    <name>B8DWF6_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VbhA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218205.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28807">
        <property type="protein sequence ID" value="ACL28807"/>
        <property type="gene ID" value="BLA_0508"/>
    </dbReference>
    <dbReference type="GeneID" id="66533638"/>
    <dbReference type="KEGG" id="bla:BLA_0508"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.537"/>
    <dbReference type="HOGENOM" id="CLU_206518_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900723">
        <property type="term" value="P:negative regulation of protein adenylylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11586">
        <property type="entry name" value="VbhA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041535">
        <property type="entry name" value="VbhA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033788">
        <property type="entry name" value="VbhA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043038">
        <property type="entry name" value="VbhA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18495">
        <property type="entry name" value="VbhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VbhA" evidence="1">
        <location>
            <begin position="21"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="71" mass="7676" checksum="9E007D8FA30739C3" modified="2009-03-03" version="1">MSVKESDVEMVRAAKAARNTRNLALALHSAEMEGGHVSDVLLHEAHDYANGLIDAATLGLRVCARYGLNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWF7</accession>
    <name>B8DWF7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0509"/>
    <dbReference type="EnsemblBacteria" id="ACL28808">
        <property type="protein sequence ID" value="ACL28808"/>
        <property type="gene ID" value="BLA_0509"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0509"/>
    <dbReference type="HOGENOM" id="CLU_3305444_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="43" mass="4874" checksum="2A994D1D4D76A13C" modified="2009-03-03" version="1">MSEPVFDPYLVPGTDLLRNLSGAHTQRELAEIEHSLVTARHWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWJ4</accession>
    <name>B8DWJ4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0546</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0546"/>
    <dbReference type="EnsemblBacteria" id="ACL28845">
        <property type="protein sequence ID" value="ACL28845"/>
        <property type="gene ID" value="BLA_0546"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0546"/>
    <dbReference type="HOGENOM" id="CLU_1369873_0_0_11"/>
    <dbReference type="OMA" id="GDIEDWD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="113"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="202" mass="22606" checksum="2EEF4C3DF6C3456E" modified="2009-03-03" version="1">MSRIPYPPAPEPGWYDDDVDAVPGVAFPAYGTQEMRRVQAHRQDGQVSEQPEWHGEPDDYAGEPDEYTAEPGSEGDAQWDGTVLSKRFARETEREAVLTNAVTNQHIDINMNTLLGRKPSHDIPEGSKSVRLIDPTRTVSRNHCAISYGEHGTLWLEDMGSLNGTYVVHDDEEMRVSQGMPVELDLPANIRIGDQFFTLDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWL0</accession>
    <name>B8DWL0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable lipoate protein ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">snoP</name>
        <name evidence="2" type="ordered locus">BLA_0564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218293.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0564"/>
    <dbReference type="EnsemblBacteria" id="ACL28861">
        <property type="protein sequence ID" value="ACL28861"/>
        <property type="gene ID" value="BLA_0564"/>
    </dbReference>
    <dbReference type="GeneID" id="66533693"/>
    <dbReference type="KEGG" id="bla:BLA_0564"/>
    <dbReference type="HOGENOM" id="CLU_022986_5_2_11"/>
    <dbReference type="OMA" id="YAYLDDW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="188"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="387" mass="42101" checksum="B3B46EFB0AA4EFD3" modified="2009-03-03" version="1">MRSGEVKIPGGKLVRVTLQGDEVRGWHATIDGDFFMEANAGSVLGRAQSAIDAHLPELPDDWEHWGSADYLAFYRALSGELRGVIGDTLIGANGEAIALAVVRALVGGGARESAQTAEREFERIREARATRQGERAQSGDEPAPMLIGLQDAKRRWARMNPQTVVDIPRMPAEQMQVDELWATQVANGERQATLRIWDWAAPAVVCGKFQSIADEVDLEYAKEHGIEVVRRDTGGGAMFIEPQNTITYSLYVPEPVVAGLDARQCYQFCDMWLLEALAACGVRAHFAGLNDIASAAGKIGGAAERRFPASGEGPGCLLHHDTLAYAMNTEHLQHVLRPSKEKMSDKAVKSASKRVDPMNSQTSCTRAQIVDCMLETASRFGVVGNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWM7</accession>
    <name>B8DWM7_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="4 6">2.7.7.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rfbA</name>
        <name evidence="8" type="ordered locus">BLA_0581</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:15225"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glucose-1-phosphate thymidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.24" evidence="4 6"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218313.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0581"/>
    <dbReference type="EnsemblBacteria" id="ACL28878">
        <property type="protein sequence ID" value="ACL28878"/>
        <property type="gene ID" value="BLA_0581"/>
    </dbReference>
    <dbReference type="GeneID" id="66533709"/>
    <dbReference type="KEGG" id="bla:BLA_0581"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.612"/>
    <dbReference type="HOGENOM" id="CLU_029499_9_0_11"/>
    <dbReference type="OMA" id="FTWLDTG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02538">
        <property type="entry name" value="G1P_TT_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005907">
        <property type="entry name" value="G1P_thy_trans_s"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43532">
        <property type="entry name" value="PTHR43532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01207">
        <property type="entry name" value="rmlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="7">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="296" mass="32948" checksum="8475604EC7BCB127" modified="2009-03-03" version="1">MKGIILAGGSGTRLYPLTTVTSKQLLPVYDKPMIFYPLSALMMAGIRDILIISTPKDLPNFERLLGDGSRYGISLQYKVQPSPDGLAQAFLLGEDFIGDDACALVLGDNIFYGNGLGRQLRKAAALEHGATVFGYYVDDPERYGVVEFDKEHKAVSIVEKPEHPASNYAVTGLYFYDNRVVDFAKQVKPSPRGELEITDLNRMYLDDGSLHVQTLGRGYAWLDTGTMDSLFEAGEFVRTVEHAQGLPISVIEEIAYENRWIDRDQLLAAAERYGKSPYGKHLLDVAEHRFLSTIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWN8</accession>
    <name>B8DWN8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cps1A</name>
        <name evidence="1" type="ordered locus">BLA_0592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0592"/>
    <dbReference type="CAZy" id="GT32">
        <property type="family name" value="Glycosyltransferase Family 32"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28889">
        <property type="protein sequence ID" value="ACL28889"/>
        <property type="gene ID" value="BLA_0592"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0592"/>
    <dbReference type="HOGENOM" id="CLU_068623_0_0_11"/>
    <dbReference type="OMA" id="YSDIVRC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008441">
        <property type="entry name" value="AfumC-like_glycosyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05704">
        <property type="entry name" value="Caps_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="353" mass="39964" checksum="5E04944C5D71BFA6" modified="2009-03-03" version="1">MSRISPMPPTRCIRAISSAVTDNTQGAWILPRKAEHLYTWKAAMGKLHNIRTKLKRYRKECVSAWRLFGPKLAMEGYLAHTVGIGVDRYYTDLSQATWSTLMEDLPYSMSIPAVDEQQCANAPIWVMWWQGVDNQAPDIIQACVRSIRKHANGHPVHVISKQNLHEYASIDESVVQAAECGEIPMAVLSDIIRCTLLYQHGGAWIDATVYLTDDINPEVFTHPIYSIPVHQKNPTRNWTSYFIASTQGNPLFDYAGRSLTHLVTRGKGIPEYFMLDVMLSVAYTRHAEFTAMIDAIPANNEGRFALSEQMDSTEAQPRIPSSTYINKLTYQIDYPTTVNGKETIYQRLLDGEF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWP6</accession>
    <name>PDXS_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal 5'-phosphate synthase subunit PdxS</fullName>
            <shortName evidence="1">PLP synthase subunit PdxS</shortName>
            <ecNumber evidence="1">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Pdx1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pdxS</name>
        <name type="ordered locus">BLA_0600</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">In the presence of PdxT, forms a dodecamer of heterodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218336.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DWP6"/>
    <dbReference type="SMR" id="B8DWP6"/>
    <dbReference type="STRING" id="442563.BLA_0600"/>
    <dbReference type="EnsemblBacteria" id="ACL28897">
        <property type="protein sequence ID" value="ACL28897"/>
        <property type="gene ID" value="BLA_0600"/>
    </dbReference>
    <dbReference type="GeneID" id="66533730"/>
    <dbReference type="KEGG" id="bla:BLA_0600"/>
    <dbReference type="HOGENOM" id="CLU_055352_1_0_11"/>
    <dbReference type="OMA" id="RYANRGW"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PTHR31829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00343">
        <property type="entry name" value="TIGR00343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0704">Schiff base</keyword>
    <feature type="chain" id="PRO_1000188213" description="Pyridoxal 5'-phosphate synthase subunit PdxS">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="234"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01824"/>
        </source>
    </evidence>
    <sequence length="291" mass="31343" checksum="EE3C1213DFF087B1" modified="2009-03-03" version="1">METTRNELNRNLAQMLKGGVIMDVTTPEQARIAEDAGACAVMALERIPADIRAAGGVSRMSDPAMIKGIQEAVSIPVMAKVRIGHIAEARILQAIEIDYIDESEVLSPADDVYHIDKREFDVPFVCGAKNLGEALRRIEEGASMIRTKGEPGTGDVIQAVRHMRTMTKQIRELASLRDDEVYEAAKQLAVPYELAKYVHDNGRLPVVNFAAGGVATPADAALMMELGAEGVFVGSGIFKSGDPAKRAAAIVQATANWRDADLLARLSENLGEAMVGINEDEIETIMAARGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWT0</accession>
    <name>B8DWT0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BLA_0638</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28931">
        <property type="protein sequence ID" value="ACL28931"/>
        <property type="gene ID" value="BLA_0638"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0638"/>
    <dbReference type="HOGENOM" id="CLU_000960_34_2_11"/>
    <dbReference type="OMA" id="CLIMLRS"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="9"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL28931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="464" mass="48701" checksum="8017E0A5F9057C7C" modified="2009-03-03" version="1">MDAKHVGALMAALMAAIFAFQLNASMLSPVLTTMRVELNTTDAEIGLTQTVFFTACAVFSLFLPRLGDLKGRKKVLIGMLACTAIGCVISACATNVTMLMIGRVIQGVAGPVVPMTLLMLHAEVTDNARYARLMAILTSVNGGIAGVDALLGGWLAGNFGFRSVFWVMCGVAVLAVVLVWSFARESTADETPKMDWLGAILLSAAFLAAYLAINEIEKLAGANWWLIAIEIVVAAVLFVIFWHVENAQKNPMVTTTYLKERRTWGLLLTTLLTMTGVFAVMNGIVPALAQDTSVGASMSADTVSLATLTPYALVGLVFGPVAGVIASKMGYRSTLRGGLIVSAIAMVFGVFVCQSPHIWGLVVLSVVLGLSYAGTANIMLNGLGIVLSPEDNPGYLPGLNAGAFNLGAGLSYAILYGVQQGFSDAHGATMGYTGAMIAGIILLVLAFLSSLLIPKPAQNAAEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWU0</accession>
    <name>B8DWU0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="6">3.2.1.78</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_0648</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="6"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219151.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="SMR" id="B8DWU0"/>
    <dbReference type="STRING" id="442563.BLA_0648"/>
    <dbReference type="CAZy" id="CBM10">
        <property type="family name" value="Carbohydrate-Binding Module Family 10"/>
    </dbReference>
    <dbReference type="CAZy" id="GH5">
        <property type="family name" value="Glycoside Hydrolase Family 5"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28941">
        <property type="protein sequence ID" value="ACL28941"/>
        <property type="gene ID" value="BLA_0648"/>
    </dbReference>
    <dbReference type="GeneID" id="66533781"/>
    <dbReference type="KEGG" id="bla:BLA_0648"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.676"/>
    <dbReference type="HOGENOM" id="CLU_018488_1_1_11"/>
    <dbReference type="OMA" id="GTAPNGY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.32.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002883">
        <property type="entry name" value="CBM10/Dockerin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036601">
        <property type="entry name" value="CBM10_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009031">
        <property type="entry name" value="CBM_fam10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02013">
        <property type="entry name" value="CBM_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01064">
        <property type="entry name" value="CBM_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51763">
        <property type="entry name" value="CBM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867576" evidence="4">
        <location>
            <begin position="30"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="CBM10" evidence="5">
        <location>
            <begin position="342"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL28941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="378" mass="40032" checksum="D95D905F52197655" modified="2009-03-03" version="1">MHTNMKKTLAAVVGAMTLAAVLPATAAQAADNSLHVSGGKIYSAGKQFVPQGINHAYQWYPEHTSSIGDIANTGANTVRVVLSGGRYGTTSASEVSNIVNECKSNNLVCILEDHDTTGYGDTAYAADAKSLSDAVQFWKSVGSAVKGQEDYVMINLGNEPYGNNTASQWTQGTKDAIRQMRDAGFRHTLVLTAPNWGQDWQGVMKDNAKSVYSQDSNVLFDVHMYGVYSTADKVKSYIDSFVNQGLPLMVGEFGNKHSDGIPDAATIMSYTKEKGVGMLAWSWCGNTEGVEYLDLVNNWNAGSLSGWGNMFVNGANGLKSRGIEKAGIYGGGSNSGGSGNTGGNSGTTDDGYPICSSASVDPDGDGWGWENNASCKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSI8</accession>
    <name>B8DSI8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Orotate phosphoribosyltransferase</fullName>
            <ecNumber evidence="2">2.4.2.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pyrE</name>
        <name evidence="2" type="ordered locus">BLA_0674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.2.10" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219111.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0674"/>
    <dbReference type="EnsemblBacteria" id="ACL28967">
        <property type="protein sequence ID" value="ACL28967"/>
        <property type="gene ID" value="BLA_0674"/>
    </dbReference>
    <dbReference type="GeneID" id="66533807"/>
    <dbReference type="KEGG" id="bla:BLA_0674"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.702"/>
    <dbReference type="HOGENOM" id="CLU_080162_0_0_11"/>
    <dbReference type="OMA" id="RTMNEEQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="220" mass="23765" checksum="3BF99A8B4E1F550D" modified="2009-03-03" version="1">MSQSQGFRPTGVSNSEQAASRTVSREEAVDFSAMEPREQLKRMLREHMADRPFSELSDVTFDSHGASLIGHILLDTIEEAGYSVDDFDAVGALTAAAVPMVCAMMHAAASRGEDLNGFVMDFVFPSIKGPSIEGKRVLLLDAWLSEKSYVQTSSLVTLRNGNELSLDFGIVEAQGAEVVAVASLIGGVDMVDPVIRVVNPADDSTAELPFIEVFRESELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSJ2</accession>
    <name>B8DSJ2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0678"/>
    <dbReference type="EnsemblBacteria" id="ACL28971">
        <property type="protein sequence ID" value="ACL28971"/>
        <property type="gene ID" value="BLA_0678"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0678"/>
    <dbReference type="HOGENOM" id="CLU_2166049_0_0_11"/>
    <dbReference type="OMA" id="RNRIRYT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="132" mass="14565" checksum="7FD4D55AD727618F" modified="2009-03-03" version="1">MLRYAQGESPVQLFREAGLDPSLIGYKRIECAIARWRRQMNVAATTVKQPRGKRGNAVMADLRAPTHIDASFAPQAIGSRGDIRDVLIAQQVRRIDELERQVDELSRELRKLSAPHGDAGSDPMGASGETRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSM4</accession>
    <name>B8DSM4_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">thgA</name>
        <name evidence="4" type="ordered locus">BLA_0710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218733.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0710"/>
    <dbReference type="EnsemblBacteria" id="ACL29003">
        <property type="protein sequence ID" value="ACL29003"/>
        <property type="gene ID" value="BLA_0710"/>
    </dbReference>
    <dbReference type="GeneID" id="66533471"/>
    <dbReference type="KEGG" id="bla:BLA_0710"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.741"/>
    <dbReference type="HOGENOM" id="CLU_051638_3_2_11"/>
    <dbReference type="OMA" id="FYSGTHP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039369">
        <property type="entry name" value="LacA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43017">
        <property type="entry name" value="PTHR43017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mac" evidence="3">
        <location>
            <begin position="12"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="213" mass="24031" checksum="B830D940AC2D9887" modified="2009-03-03" version="1">MTNGTSADTREYERMLSGELYIADDPYLKEHSLKRRRLVQEINRSDYDEFDKREALFRELFGSFGEGSYIEPPFRADYGCNTYIGRNFYANTDCIFLDVARIDIGDNVFCGPRVSLLTPYHPIDAQVRNEQLEGGKPISIGNDVWFGGNVTVCPGVTIGDDVVIGAGSVVVKDIPSHCIAVGNPCRPIRAITDADHEQWQRKAREYRAWKEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSM6</accession>
    <name>B8DSM6_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aconitate hydratase</fullName>
            <shortName evidence="10">Aconitase</shortName>
            <ecNumber evidence="10">4.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">acnA</name>
        <name evidence="13" type="ordered locus">BLA_0712</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:17941"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="ChEBI" id="CHEBI:57872"/>
            <dbReference type="EC" id="4.2.1.99"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <text evidence="10">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="10"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218731.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0712"/>
    <dbReference type="EnsemblBacteria" id="ACL29005">
        <property type="protein sequence ID" value="ACL29005"/>
        <property type="gene ID" value="BLA_0712"/>
    </dbReference>
    <dbReference type="GeneID" id="66533473"/>
    <dbReference type="KEGG" id="bla:BLA_0712"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.743"/>
    <dbReference type="HOGENOM" id="CLU_013476_2_1_11"/>
    <dbReference type="OMA" id="NGGIMQY"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00718"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047456">
        <property type="term" value="F:2-methylisocitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01580">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044137">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006249">
        <property type="entry name" value="Aconitase/IRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="PTHR11670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01341">
        <property type="entry name" value="aconitase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="11">
        <location>
            <begin position="63"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_C" evidence="12">
        <location>
            <begin position="691"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACL29005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="899" mass="97986" checksum="880EE1503F38C9B0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSN9</accession>
    <name>B8DSN9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_0725</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218716.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0725"/>
    <dbReference type="EnsemblBacteria" id="ACL29018">
        <property type="protein sequence ID" value="ACL29018"/>
        <property type="gene ID" value="BLA_0725"/>
    </dbReference>
    <dbReference type="GeneID" id="66533486"/>
    <dbReference type="KEGG" id="bla:BLA_0725"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.756"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OMA" id="PKYLFCD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="17"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="268" mass="29516" checksum="B2A6091CA793BE42" modified="2009-03-03" version="1">MSKQARTVTNPDDPVVARAVDLVKTYGDTDSQVTALNHVSVEFQRGELTAIMGPSGSGKSTLMHCMAGLDVPTSGQVFVEDLEVSSMKQKQLTQLRRKEIGFIFQSFNLVPTLTAEENILLPLQIAHRPVDRDWFRKVVGVVGLENRLDHRPSQLSGGQQQRVACARAMMERPSVIFADEPTGNLDSRSSREVLGFLRQCVQDYGQSIVMVTHDPRAASFADRVLVLSDGSITQDMDHPTYDDILAVFAEHDDPDNGPVDVEPAAREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSP0</accession>
    <name>B8DSP0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ABC transport system integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BLA_0726</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619816.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0726"/>
    <dbReference type="EnsemblBacteria" id="ACL29019">
        <property type="protein sequence ID" value="ACL29019"/>
        <property type="gene ID" value="BLA_0726"/>
    </dbReference>
    <dbReference type="GeneID" id="66533487"/>
    <dbReference type="KEGG" id="bla:BLA_0726"/>
    <dbReference type="HOGENOM" id="CLU_012341_1_0_11"/>
    <dbReference type="OMA" id="LIMWRLS"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="814"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="869"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="907"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="17"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="311"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="515"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="846"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="691"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL29019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="944" mass="99971" checksum="ADA8F71E9562F15A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSP3</accession>
    <name>B8DSP3_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prephenate dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">pheA</name>
        <name evidence="12" type="ordered locus">BLA_0729</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218708.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0729"/>
    <dbReference type="EnsemblBacteria" id="ACL29022">
        <property type="protein sequence ID" value="ACL29022"/>
        <property type="gene ID" value="BLA_0729"/>
    </dbReference>
    <dbReference type="GeneID" id="66533490"/>
    <dbReference type="KEGG" id="bla:BLA_0729"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.760"/>
    <dbReference type="HOGENOM" id="CLU_035008_0_2_11"/>
    <dbReference type="OMA" id="PLMIYRE"/>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="10">
        <location>
            <begin position="7"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="11">
        <location>
            <begin position="252"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="site" description="Essential for prephenate dehydratase activity" evidence="9">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001500-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACL29022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="371" mass="40930" checksum="AAC54E78828E91DA" modified="2009-03-03" version="1">MTRQSTRIHYLGPQGSFTHQAAIESAAEASRRLHMDVADFEFVACDTVPQILHAVELGQGWGTIAWENNVEGFVVPNLDLMMDAADAAGFLRVGVNVRFDAFVTERTYRHACEQYASEIAVDDAQIPARDNANAYGAASTPPTIDELAIRDCTAVCAHSHGLAQCRRFAREHGLKPVPAASNAAACRDLQDFQIALGPSICANIYGLHRVAANVGDFDGARTEFLTIAPRSQVVERLRIPRSDPKTEFESVIAFIPLVTGPGVLANLLDVLRDAQLNMVSLISRPVKGRDGTYSFLATLDAAPWDERFVNALVEICEHGDWVRTLAVYPRDERNYPTVSEWMLPAGGVRFEGEPHMANWRESADVRKELLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSS7</accession>
    <name>B8DSS7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted ATP-dependent serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218663.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0763"/>
    <dbReference type="EnsemblBacteria" id="ACL29056">
        <property type="protein sequence ID" value="ACL29056"/>
        <property type="gene ID" value="BLA_0763"/>
    </dbReference>
    <dbReference type="GeneID" id="66533525"/>
    <dbReference type="KEGG" id="bla:BLA_0763"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.795"/>
    <dbReference type="HOGENOM" id="CLU_688243_0_0_11"/>
    <dbReference type="OMA" id="GDSHKNT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="400" mass="43494" checksum="F6BC5DD1305F56FF" modified="2009-03-03" version="1">MGVEVAANPQQQAIADALWDNVEKQARAQHDGRRIALTRACDVKVERPVFLHNPLVPTKVLTLIAGRAGVSKSTLSIDIAAKATLGKLTGDWQHQPVTVAFAAIEDDMGMQKARLQAAGADMNRVLFLTVDDTRDGNTVSTGLQLPDDTATLRDTLREHDVKLLVIDPITSCIDGNTDKRDDVRRSLDPLAATAQELGIAIIGILHFNKGGGYASDKVSGSHAFRDTVRSLILVAKDDETGECVVTLDKSSYTPQQGASYKYTLAPRFITDDDGERMEVPIIAGFTPTDTNVNEVINRNVTGGDTTGRAADNEVADWLTAYLAENGPTNCKQIAADAKDAEGYTFKQLQHARERLTSPRVIARKDPTYTGRGRRSLWELEQPECTSTYYAPSTHGVKYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSS9</accession>
    <name>B8DSS9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218661.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29058">
        <property type="protein sequence ID" value="ACL29058"/>
        <property type="gene ID" value="BLA_0765"/>
    </dbReference>
    <dbReference type="GeneID" id="66533527"/>
    <dbReference type="KEGG" id="bla:BLA_0765"/>
    <dbReference type="HOGENOM" id="CLU_2894947_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="62" mass="6979" checksum="9CDD757694950E91" modified="2009-03-03" version="1">MNDIYQLPALNRTIDALHLDDDRHAAQITAARLIAEQLDYSDKPTATLCAAYVRLLHDLTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>B8DST1</accession>
    <name>B8DST1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218659.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29060">
        <property type="protein sequence ID" value="ACL29060"/>
        <property type="gene ID" value="BLA_0767"/>
    </dbReference>
    <dbReference type="GeneID" id="66533529"/>
    <dbReference type="KEGG" id="bla:BLA_0767"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.799"/>
    <dbReference type="HOGENOM" id="CLU_2231285_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="105" mass="11960" checksum="426B485C92F1AF77" modified="2009-03-03" version="1">MNPIIYADMHEHRLGLSFIAAQYDDTGIEAMLDQSNTIDFTSPDELDALADYARHELADWLEECARQYRNATQPTDNTDTEDTTMHRNPTHPYTGTPQPNRTTMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DST4</accession>
    <name>B8DST4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP binding protein of ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_0770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218656.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0770"/>
    <dbReference type="EnsemblBacteria" id="ACL29063">
        <property type="protein sequence ID" value="ACL29063"/>
        <property type="gene ID" value="BLA_0770"/>
    </dbReference>
    <dbReference type="GeneID" id="66533532"/>
    <dbReference type="KEGG" id="bla:BLA_0770"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.802"/>
    <dbReference type="HOGENOM" id="CLU_000604_86_2_11"/>
    <dbReference type="OMA" id="YEACPND"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="18"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="307"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="342"/>
            <end position="349"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="576" mass="62958" checksum="583543DC46B988ED" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSV2</accession>
    <name>B8DSV2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidoglycan-binding LysM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29081">
        <property type="protein sequence ID" value="ACL29081"/>
        <property type="gene ID" value="BLA_0789"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0789"/>
    <dbReference type="HOGENOM" id="CLU_136034_2_7_11"/>
    <dbReference type="OMA" id="FAWIIFT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="70"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="122" mass="13317" checksum="8F8D9206947EDD68" modified="2009-03-03" version="1">MFEGVVMRSKSIVQVQAKTVSERYRNSFLRAHHRVLAVVVTISACFALCCVTAGARESDAVVEAASSEVVHYTVQPGDSLWSIASRFPGDSSSAYQRVERLKQVNNLRGGSLRAGQHLVIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSZ0</accession>
    <name>B8DSZ0_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)</fullName>
            <ecNumber evidence="4">1.17.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">ispG</name>
        <name evidence="6" type="ordered locus">BLA_0827</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:43604"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:10623"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IspG family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.3" evidence="4"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218578.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0827"/>
    <dbReference type="EnsemblBacteria" id="ACL29119">
        <property type="protein sequence ID" value="ACL29119"/>
        <property type="gene ID" value="BLA_0827"/>
    </dbReference>
    <dbReference type="GeneID" id="66533588"/>
    <dbReference type="KEGG" id="bla:BLA_0827"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.861"/>
    <dbReference type="HOGENOM" id="CLU_042258_0_0_11"/>
    <dbReference type="OMA" id="PTCGRTQ"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00159">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016425">
        <property type="entry name" value="IspG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="PTHR30454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004640">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00612">
        <property type="entry name" value="ispG_gcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="400" mass="42217" checksum="F33977F126B52C12" modified="2009-03-03" version="1">MSEPTFRKTGEAAVSESPLHARRKSRRIMVGPVPVGGGAPISVQSMTNTKTSDVGATLQQIAELTAAGCDIVRVAVPNQEDADALPKIVAKSPIPVIADIHFQSKYVFEAIDAGCAAVRVNPGNIRKFDEVGPQICKAATDAGISLRIGVNAGSLDKELYAKYGGPTPEALVASALKEARMFEDVGFHDFKISVKHHDPVTMVETYRLLASKGDWPLHLGVTEAGPAWQGTIKSCVAFGALLAEGIGDTIRVSLSAPPVEEVKVGCKILEYLGLRPRKFDIISCPSCGRAQVDVIQLANAVTEGLKGITAPIRVAVMGCIVNGPGEAREADLGVASGNGKGRIFIKGEVVETVPEDRIVETLLKYAHEIAATMGENEDGMGTGPVVMPLTGENLHRKPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSZ3</accession>
    <name>B8DSZ3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218572.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29122">
        <property type="protein sequence ID" value="ACL29122"/>
        <property type="gene ID" value="BLA_0830"/>
    </dbReference>
    <dbReference type="GeneID" id="66533592"/>
    <dbReference type="KEGG" id="bla:BLA_0830"/>
    <dbReference type="HOGENOM" id="CLU_1623931_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="163" mass="18305" checksum="608B558CCC3B6833" modified="2009-03-03" version="1">MTSIFESVSNQLSSLPHLIPSFVRKPNENDERIDDLENQIARLDRESKWCDVELDRRIKELTAEVDSLKRTQHHDRSLRTADRVLAIVFMSLAALILVPMFLTLFHVIDPSGETIRWVVFALFAVAGGMGVAITIAHGKLPRTRDSLIVFVCAALLLLVACLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT57</accession>
    <name>B8DT57_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0894</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0894"/>
    <dbReference type="EnsemblBacteria" id="ACL29186">
        <property type="protein sequence ID" value="ACL29186"/>
        <property type="gene ID" value="BLA_0894"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0894"/>
    <dbReference type="HOGENOM" id="CLU_069356_44_1_11"/>
    <dbReference type="OMA" id="RAPKGDM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="222" mass="24957" checksum="A80BBFF9AA26494E" modified="2009-03-03" version="1">MCDARKWWRNMAERPETQEKRKVILRAATEVFGEKGATKGTLEDIAEKVGMTRAGVLHHFGSKDNLLLQTVIYRDSVDLEDYPEDMARGGMPEDGAITFRHLIKTAKANEARPGLVKAFIAFCADSIREDSPAYDYFVSRYRNLRRMLEKALRIMADELGKSVDDATICNTAMSILAVMDGLQIQWMLDPDAIGLAEETERAIKLMLAGALDLNDEERDAIL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT61</accession>
    <name>GRPE_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">grpE</name>
        <name type="ordered locus">BLA_0898</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219270.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DT61"/>
    <dbReference type="SMR" id="B8DT61"/>
    <dbReference type="STRING" id="442563.BLA_0898"/>
    <dbReference type="EnsemblBacteria" id="ACL29190">
        <property type="protein sequence ID" value="ACL29190"/>
        <property type="gene ID" value="BLA_0898"/>
    </dbReference>
    <dbReference type="GeneID" id="66533878"/>
    <dbReference type="KEGG" id="bla:BLA_0898"/>
    <dbReference type="HOGENOM" id="CLU_057217_4_0_11"/>
    <dbReference type="OMA" id="YAYEKIA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_1000164179" description="Protein GrpE">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="229" mass="24732" checksum="FA3857C9C64A64F0" modified="2009-03-03" version="1">MSDFNKDDYLNDLPDADELANGQASPDADGADAPSDTGEQLKDDMLKDAAAEQSAGEQASEESAKAAAEATADAASDGDAEGSSLTPLGQAKKEAAEYLEALQRERAEFINYRNRTKKDMDRARQQGIIDVLTAMLPGLDDIDRIREHGEMDDSFKAVAAKIDKTFEKFGVEKFGLKGEDFDPTKHEAILHKPDPEASKATVDTVVEAGYRIGDRVIRAARVVVASPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT79</accession>
    <name>B8DT79_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">trpS</name>
        <name evidence="9" type="ordered locus">BLA_0063</name>
        <name evidence="10" type="ordered locus">BLA_0916</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218354.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0063"/>
    <dbReference type="EnsemblBacteria" id="ACL28366">
        <property type="protein sequence ID" value="ACL28366"/>
        <property type="gene ID" value="BLA_0063"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29208">
        <property type="protein sequence ID" value="ACL29208"/>
        <property type="gene ID" value="BLA_0916"/>
    </dbReference>
    <dbReference type="GeneID" id="66532439"/>
    <dbReference type="KEGG" id="bla:BLA_0063"/>
    <dbReference type="KEGG" id="bla:BLA_0916"/>
    <dbReference type="HOGENOM" id="CLU_029244_0_1_11"/>
    <dbReference type="OMA" id="LGHYFGT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL28366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL29208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="367" mass="40223" checksum="1EF324A2228CF9F0" modified="2009-03-03" version="1">MTDDMNAQLTAAGNEMSASFLAAKKRSDETLAKLKANPGKFTMLTGDRPTGRLHLGHFFGSIRERVAMQNLGVNTNIIIADYQVITDRDTTEHIDDNVLNLVLDYMAAGIDPEKTMIFTHSAVPAENQLMLPFLSLVTEAELHRNPTVKSEMESSGHALTGLLLTYPVHQACDILFCKANVVPIGKDNLPHVEITRTIARRFNERYAKKNPVFPEPAAILSEAPEIPGLDGRKMSKSYGNSIMLGATAEETAKLIKKSPTDSERTITFDPVNRPQVSALLTTAGLVTGRDPSEIAAEIGNAGAGALKKYVIDSVNEFLAPHRERRAELAKDMDSVRDILHDGNARANAIANQTLDEVREAMGMRYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT86</accession>
    <name>B8DT86_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0923"/>
    <dbReference type="EnsemblBacteria" id="ACL29215">
        <property type="protein sequence ID" value="ACL29215"/>
        <property type="gene ID" value="BLA_0923"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0923"/>
    <dbReference type="HOGENOM" id="CLU_051632_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="304" mass="31770" checksum="D14B3547A76A1921" modified="2009-03-03" version="1">MVTSFTGAYGSLAKLQVEDFLNLTRMTALADAASSGSSVSVASLNAAAGSVIADLTGNADAYPQIAIAEDPAGTDDREANGRYAFQTMMDMGAYPMVAAMFTITAMTMGSFSGARVRRRMYASPQRTGSMLFQQFACCGLFGVLVSLFYLALALALPVAAGLPITGVDPRGFLLCALTMVAYSLTAAASGFMVSMIAVNSAAINAIANVYGLVIMFTSGMAFPVDLMPKVMIVIGKCTPGWWFCRSISAAMNSEGTVSVSNWFPGIALVLLFGVAFIALGLALSQMRRLRPNLAAPASTQLAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT90</accession>
    <name>B8DT90_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase</fullName>
            <ecNumber evidence="8 9">2.8.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA-i(6)A37 methylthiotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">miaB</name>
        <name evidence="14" type="ordered locus">BLA_0927</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37067"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="Rhea" id="RHEA-COMP:10376"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="ChEBI" id="CHEBI:74417"/>
            <dbReference type="EC" id="2.8.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.3" evidence="8 9"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0927"/>
    <dbReference type="EnsemblBacteria" id="ACL29219">
        <property type="protein sequence ID" value="ACL29219"/>
        <property type="gene ID" value="BLA_0927"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0927"/>
    <dbReference type="HOGENOM" id="CLU_018697_2_2_11"/>
    <dbReference type="OMA" id="CEHFHIP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01864">
        <property type="entry name" value="tRNA_metthiotr_MiaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="12">
        <location>
            <begin position="35"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="178"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="11">
        <location>
            <begin position="410"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACL29219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="491" mass="54591" checksum="149F9D4F2D798C2B" modified="2009-03-03" version="1">MTPEERRTNISQAQHTTQVEPGAPQYGGASGRGRGLYYVHTLGCQMNVHDSERIAGVMEENGYRPASEEQFLAHDVDVVIMNTCAVRENATERMYGTIGKWKRFKYRNPHAQIAIGGCMAQLDRERIAKRTPWVDAVFGTKNIEDLPALLDQARAAQHTQVKVNEDLTLFPSQLPAHRASAHSAWVAISMGCNNTCTFCIVPTTRGKERDRRPGDVLAEIRETVTNGAKEITLLGQNVNSYGYGIGDRYAFSKLLRACGEIEGLERVRFTSPHPAAFTDDVIAAMAETPNVMHQLHFPLQSGSDRILRAMRRSYRSERFLGILAKIREAMPDAQISTDIIVGFPGETEEDFQQTLRVVEEARFSSAFTFIYSPRPGTPAAAMEQVPYDVALDRLERLLAVQERITEEILEKFVGRDVEVMITGVTGKKDAETHRYTGREKTGVLVHVGVPEGHDAPQIGDFVTATVTHAGRHNLIADPDLAKGQTYAIRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT99</accession>
    <name>B8DT99_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome hibernation promoting factor</fullName>
            <shortName evidence="2">HPF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hpf</name>
        <name evidence="5" type="ordered locus">BLA_0936</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with 100S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217596.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0936"/>
    <dbReference type="EnsemblBacteria" id="ACL29228">
        <property type="protein sequence ID" value="ACL29228"/>
        <property type="gene ID" value="BLA_0936"/>
    </dbReference>
    <dbReference type="GeneID" id="66533450"/>
    <dbReference type="KEGG" id="bla:BLA_0936"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.979"/>
    <dbReference type="HOGENOM" id="CLU_071472_0_0_11"/>
    <dbReference type="OMA" id="HGGYGVI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00839">
        <property type="entry name" value="HPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034694">
        <property type="entry name" value="HPF_long/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="4">
        <location>
            <begin position="156"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="228" mass="25606" checksum="43421A97E56EC443" modified="2009-03-03" version="1">MDIVLTGRHIQIKQKFRDVVESKMNRVTTIAPDAQRVQVVLSHEGNPRLHDTAVRVELTVVAGSTVVRAEASSLDEVSALDLALDKLTLRLRRARDRRKDHRKNYTPVPVDAGKFVPPSEEREDIMGDEDVDNSPASAVAGDLGPGESVEVHVGDTPIVIRRKLHVAEPMSIDEALYEMELIGHDFFLFVNKDTGRPSVVYHRHGWSYGVFEIDTPENIKKLEEERKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTA8</accession>
    <name>B8DTA8_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gyrB</name>
        <name evidence="7" type="ordered locus">BLA_0945</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217608.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0945"/>
    <dbReference type="EnsemblBacteria" id="ACL29237">
        <property type="protein sequence ID" value="ACL29237"/>
        <property type="gene ID" value="BLA_0945"/>
    </dbReference>
    <dbReference type="GeneID" id="66533441"/>
    <dbReference type="KEGG" id="bla:BLA_0945"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.988"/>
    <dbReference type="HOGENOM" id="CLU_006146_4_1_11"/>
    <dbReference type="OMA" id="NTWEVDG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Toprim" evidence="6">
        <location>
            <begin position="554"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="779" mass="85564" checksum="3FD2BB86F5057FC0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTC4</accession>
    <name>B8DTC4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Permease protein of ABC transporter system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_0963</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217625.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0963"/>
    <dbReference type="EnsemblBacteria" id="ACL29253">
        <property type="protein sequence ID" value="ACL29253"/>
        <property type="gene ID" value="BLA_0963"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0963"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1006"/>
    <dbReference type="HOGENOM" id="CLU_077375_0_1_11"/>
    <dbReference type="OMA" id="TFWSAIF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="28"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="236" mass="25643" checksum="328A13A6BA8C69B4" modified="2009-03-03" version="1">MHILAFDQTTLASRSDWSVLRPLLGQSVVQTLQMVLITIVVGGFLGLILGVILYGTRPGNLFENRYVYRILDILVNIIRPIPFIIFLAAMQPLTIKVIGTSIGTAAAIFPMCVMCTFATSRLVEQNLVPVDPGVIEAARSMGASKFTIIRTVLIPEALAPLILAYAFLFIGVLDMSAMAGYIGGGGLGNFAIAYGYQKFDQTVTWTAVIIMILLVQVVQSIANAIAKHLLRRTQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTC5</accession>
    <name>B8DTC5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase, M20/M25/M40 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217628.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0964"/>
    <dbReference type="EnsemblBacteria" id="ACL29254">
        <property type="protein sequence ID" value="ACL29254"/>
        <property type="gene ID" value="BLA_0964"/>
    </dbReference>
    <dbReference type="GeneID" id="66533425"/>
    <dbReference type="KEGG" id="bla:BLA_0964"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1007"/>
    <dbReference type="HOGENOM" id="CLU_023257_1_1_11"/>
    <dbReference type="OMA" id="EWHHPAF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="183"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="387" mass="42132" checksum="D08C83415EBEFCE1" modified="2009-03-03" version="1">MTDHTEHVEIALTDELLGIRRRLHRHPERSFKEFETSMRLRNLLESHGITVLDNPLDTGVIGEIKGEHDGPQIGLRADIDALPVHEDSGLVFASENEGVMHACGHDIHMTSLLGAAFWLAAHRELIHGTIRLVFQPAEELGQGARAVADAGLVDGLDAMIGTHNNPDYKPGQIAVGVDPMMAGCVKFRVNLHAQGTHAGYPHRGTGPLEAMAAMVLSLQTIVSRNASPFHPLVISVTEVHGGDVWNVVPAEAGFQGTARYFHREDGDLAERRFRQVIESTAAAYDIAVDYVWDDFQRPLVSDPDLATLAMSHVPEYAQLEPIHPSMAGEDFAEYEGHTRLLFAFIGSNGSGGCADLHSPKFVALDDAVKTGAEFYANSALEVLEHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTC9</accession>
    <name>B8DTC9_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pyruvate formate-lyase-activating enzyme</fullName>
            <ecNumber evidence="9">1.97.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pflA</name>
        <name evidence="11" type="ordered locus">BLA_0968</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[formate C-acetyltransferase] + H(+) + L-methionine + semiquinone [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:19225"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:12190"/>
            <dbReference type="Rhea" id="RHEA-COMP:12191"/>
            <dbReference type="Rhea" id="RHEA-COMP:14480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29947"/>
            <dbReference type="ChEBI" id="CHEBI:32722"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:140311"/>
            <dbReference type="EC" id="1.97.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <dbReference type="EC" id="1.97.1.4" evidence="9"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217632.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0968"/>
    <dbReference type="EnsemblBacteria" id="ACL29258">
        <property type="protein sequence ID" value="ACL29258"/>
        <property type="gene ID" value="BLA_0968"/>
    </dbReference>
    <dbReference type="GeneID" id="66533421"/>
    <dbReference type="KEGG" id="bla:BLA_0968"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1011"/>
    <dbReference type="HOGENOM" id="CLU_058969_1_1_11"/>
    <dbReference type="OMA" id="IGVPNKR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043365">
        <property type="term" value="F:[formate-C-acetyltransferase]-activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012838">
        <property type="entry name" value="PFL1_activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001989">
        <property type="entry name" value="Radical_activat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02493">
        <property type="entry name" value="PFLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01087">
        <property type="entry name" value="RADICAL_ACTIVATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="71"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL29258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="300" mass="33884" checksum="B1127DBD6054B4E7" modified="2009-03-03" version="1">MSNSESNHGASAFRTTTRHMLKSSKEYQRKTLMGGLSGFESPIGLDRRDRINALKTGDIGFVHSWDINTSVDGPGTRMTVFLSGCPLRCQYCQNPDTWKMRDGKPVYLDAMVVKIERYKDLFEATKGGITFSGGESMMQPAFVSRVFRAAKEMGVHTCLDTSGFLNANYSDEMIDDIDLCLLDVKSGDEETYKRVTGGVLQPTIDFGQRLNRRGKKIWVRFVLVPGLTSSEENVENVARICESFGDAVEHIDVLPFHQLGRPKWHELRIPYPLEDQKGPSQALRDRVRQQFESHGFTVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTD9</accession>
    <name>B8DTD9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">safC</name>
        <name evidence="4" type="ordered locus">BLA_0978</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217645.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0978"/>
    <dbReference type="EnsemblBacteria" id="ACL29268">
        <property type="protein sequence ID" value="ACL29268"/>
        <property type="gene ID" value="BLA_0978"/>
    </dbReference>
    <dbReference type="GeneID" id="66533409"/>
    <dbReference type="KEGG" id="bla:BLA_0978"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1021"/>
    <dbReference type="HOGENOM" id="CLU_067676_2_0_11"/>
    <dbReference type="OMA" id="WEYVEDH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="223" mass="24415" checksum="ABCA8306492B4891" modified="2009-03-03" version="1">MDRTSFENHARAWDWIETREFALEPDLVHEARTLMQEDNDPSVSACEGAMLSMFKTMSGASSVIVIGTGSLVQTARIACSLNDDDKLTAVDSTPQGHSQIKRLFRTAATMTRATLRTVNADPTQFLSRLNGDDYDLIVVCGDASNYPAAYEQAPRLLRRHGVIIFTDVLAMESPDSKGGLTNPADRGDKAVAMRELIDAVTDDDRFISALSQTGWGMLIATLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTG1</accession>
    <name>B8DTG1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Possible ATP-dependent RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_1000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1000"/>
    <dbReference type="EnsemblBacteria" id="ACL29290">
        <property type="protein sequence ID" value="ACL29290"/>
        <property type="gene ID" value="BLA_1000"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1000"/>
    <dbReference type="HOGENOM" id="CLU_003041_27_1_11"/>
    <dbReference type="OMA" id="NFGNRVD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="57"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="283"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="658" mass="74340" checksum="61718D55282B7B93" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTH7</accession>
    <name>B8DTH7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29306">
        <property type="protein sequence ID" value="ACL29306"/>
        <property type="gene ID" value="BLA_1016"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1016"/>
    <dbReference type="HOGENOM" id="CLU_2876785_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="76" mass="8685" checksum="A351D6956721DA31" modified="2009-03-03" version="1">MVCGRRASTKRWFMRLLPYIPFIVPELAIGRVPMDDLTISGFRVDYRQLGASYVNRIPALRSLDELEFGSPVVLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTI4</accession>
    <name>B8DTI4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible N-acetyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1023"/>
    <dbReference type="EnsemblBacteria" id="ACL29313">
        <property type="protein sequence ID" value="ACL29313"/>
        <property type="gene ID" value="BLA_1023"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1023"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1069"/>
    <dbReference type="HOGENOM" id="CLU_013985_4_3_11"/>
    <dbReference type="OMA" id="IFAHNQP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="185" mass="20639" checksum="5F92DF2AE00F6B00" modified="2009-03-03" version="1">MQQFRYRLATVDDVAVITDIYNEAVMAGGSTADTVPVTYEARRRWIESHVDPYAVFVFETIAGDGEAEEVGFGAISVFYDRPGYDGVCDLAYYVTARWQRRGVGRFALRTLLNECRARAMRKACAIIFSDNTASNALVESFGFEPFGEMPEAAYDSRGVLHDMSYWCLDLTPLDAKGAVEGIARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTJ1</accession>
    <name>B8DTJ1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217717.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1032"/>
    <dbReference type="EnsemblBacteria" id="ACL29320">
        <property type="protein sequence ID" value="ACL29320"/>
        <property type="gene ID" value="BLA_1032"/>
    </dbReference>
    <dbReference type="GeneID" id="66533357"/>
    <dbReference type="KEGG" id="bla:BLA_1032"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1079"/>
    <dbReference type="HOGENOM" id="CLU_097805_1_0_11"/>
    <dbReference type="OMA" id="IAHRCPC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007511">
        <property type="entry name" value="DUF501"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37163">
        <property type="entry name" value="PTHR37163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04417">
        <property type="entry name" value="DUF501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="202" mass="21898" checksum="5E027236D9CC4AF4" modified="2009-03-03" version="1">MSKEGRNANGIETLAAETLQRVMEHPATQNDIATVETQLGRYPRGMVAVGARCVGDGTPLVVITGPVLPGGIPFPTTMYLTSPEAVKAVSHLEADGLMRQYNEMLADDTNLRAQYERAHAAYLAFRHGLAERLNESEEHIEGISAGGMPVRVKCLHALVAQSLVMGPGVNPIGDMALERMRNEFDPTVCRCVRAQSDGQETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTM1</accession>
    <name>B8DTM1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Possible helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218757.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1062"/>
    <dbReference type="EnsemblBacteria" id="ACL29350">
        <property type="protein sequence ID" value="ACL29350"/>
        <property type="gene ID" value="BLA_1062"/>
    </dbReference>
    <dbReference type="GeneID" id="66532891"/>
    <dbReference type="KEGG" id="bla:BLA_1062"/>
    <dbReference type="HOGENOM" id="CLU_001613_7_2_11"/>
    <dbReference type="OMA" id="ITLHQFA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="489" mass="53493" checksum="CBB15984BF317455" modified="2009-03-03" version="1">MKQSEALEIMLAGASAFLTGAPGAGKTYVLNRFVQAKREQGSTVAVTATTGIAATHVDGQTIHAWSGIGVADSLTDSLIKTIRTRRRKQIKSTDVLVIDEISMMHAWLFDMVDEVCRIIRKDSRPFGGLQVVLSGDFFQLPPVGASRRNTAMTPTPEYVSMRERYAQAGKNPEGFVTESFAWDALDPVICYLDEQHRQDDGQLLRVLTDIRGDMVSQIDKDILITRYQVPLEEGKQAVSLFPQNRQADLVNERQLAQIDGDEHEFFAEARGQANLIERLKRNMLAPEHLVLKKNAVVMAVRNDAEGRYVNGSLGMVIGFLKDARGGWPIVEFENGNVVTMKRADWEMMDGDDVLASVSQVPLRCAWAITIHKSQGMTLDSAIMDLSRTFAPGMGYVALSRVEKLDGLYLNGVHNRMFNVSADAVLLDDALRAGSARAAAQLAEQGADSFSHRSPDHAVLGATGESGAAESTQTLFDALDEFGGTGEPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTN4</accession>
    <name>B8DTN4_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide chain release factor 2</fullName>
            <shortName evidence="4">RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">prfB</name>
        <name evidence="6" type="ordered locus">BLA_1075</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="4">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218771.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1075"/>
    <dbReference type="EnsemblBacteria" id="ACL29363">
        <property type="protein sequence ID" value="ACL29363"/>
        <property type="gene ID" value="BLA_1075"/>
    </dbReference>
    <dbReference type="GeneID" id="66532901"/>
    <dbReference type="KEGG" id="bla:BLA_1075"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1125"/>
    <dbReference type="HOGENOM" id="CLU_036856_6_0_11"/>
    <dbReference type="OMA" id="YVFHPYQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00020">
        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0488">Methylation</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCRF" evidence="5">
        <location>
            <begin position="84"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="4">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="377" mass="41861" checksum="71453E85E2D619A5" modified="2009-03-03" version="1">MAEFDYSQAISDARAKYESIALALDTDRLKSQEAELEQQASAPGLWDDSEHAQKVMSQLSACQSQLKHLSSAASRLDDVATLIELGQEENDADTLHEAQTEIESIQKDLDQMEIETLMDGEYDSRSAVVTIRSGAGGVDAADFAQMLLRMYLRWAERNGYKAKVMDTSYAEEAGIKSATFQIDAPYAYGRMSVEGGTHRLVRISPFDNQGRRQTSFAAVEVVPLVEATDHIEVPDSEIRVDTYCASGPGGQGVNTTYSAVRITHLPTGIVVTMQDERSQIQNRAAAMAVLQSRLLVLRHEEEAKKKKELAGDIKASWGDQMRSYVLHPYQMVKDLRTGCETSQTQAVFDGDIDEFIQAGIRWRHEQRLEAAAEEANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2021-02-10" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTR1</accession>
    <name>B8DTR1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF1706"/>
    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="47" mass="5686" checksum="A197ADB0829F4907" modified="2009-03-03" version="1">MLAYQLGWIGLLLDWEHAEQEGHVMHMPAPEYSWNRLGELYEMFYET</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
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                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
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        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29393">
        <property type="protein sequence ID" value="ACL29393"/>
        <property type="gene ID" value="BLA_1105"/>
    </dbReference>
    <dbReference type="GeneID" id="66532929"/>
    <dbReference type="KEGG" id="bla:BLA_1105"/>
    <dbReference type="HOGENOM" id="CLU_1861294_0_0_11"/>
    <dbReference type="OMA" id="EHTEVAW"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="127" mass="14449" checksum="963022DFE6336D36" modified="2009-03-03" version="1">MRQSLEQVDPQLIAHTLDEGSATDRIDLLDVLYELMERKLYPNKEKLDDDEHTKVAWALEDGAYSVTRIRHDSLLFHALFRHFNGNEKALTDALAPSIIDELSADLYALMTPEMLAQRIASLLARNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTZ9</accession>
    <name>B8DTZ9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">BLA_1190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
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                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
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    </dbReference>
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            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="260" mass="26778" checksum="D6A4BF558AFFD5C0" modified="2009-03-03" version="1">MHITTMVLGIIGILIAGLYLYANGNISGTPRAAAMSDCRSSVSHANSARSLLTTAVGDAKTYRASHVTDMSDEQLRNLTSYLDQSAQQPSVPSCSIIANDGVLQTNAVNAKKLAHNATTLTRDLLLATTGVLPQELQGDEQTGDPSYSPSETQMPTESPQPPTSPSTDSSTHGTTSDDAKSHNDSGTANELASPSAQPSNTSRTSPEPSPSPSASMSTSSEDAGTGKRKQKESGSSASSQSEGNGSNTTKSNGTKSGNVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU02</accession>
    <name>B8DU02_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protease</fullName>
        </submittedName>
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        <name evidence="3" type="primary">clpC</name>
        <name evidence="3" type="ordered locus">BLA_1193</name>
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    <organism evidence="3 4">
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Bifidobacteriales</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
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                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ACL29481">
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        <property type="gene ID" value="BLA_1193"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|442563.4.peg.1255"/>
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    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="32"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="156" mass="17466" checksum="DDC456FA7B688416" modified="2009-03-03" version="1">MGNGGPGVERAQQQFRPEFLNRLDDIIVFRQLTEPQVRQIVDLDVTKINDRLFERHMELDLTDKAKDLLAEKGFDPLLGARPLRRVIQRDIEDTISEKILMGDLHDNERVIVDAEGDGILGEFTFRGEPFELPAAGEGDESKDVVPEPAAAASEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU30</accession>
    <name>B8DU30_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1221</name>
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    <organism evidence="2 3">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
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                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ACL29509">
        <property type="protein sequence ID" value="ACL29509"/>
        <property type="gene ID" value="BLA_1221"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_022171_0_0_11"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <location>
            <begin position="262"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
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            <begin position="422"/>
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        <location>
            <begin position="514"/>
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        </location>
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        </location>
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        </location>
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        <location>
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            <end position="690"/>
        </location>
    </feature>
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        <location>
            <begin position="696"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="720"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ACL29509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="765" mass="84804" checksum="0A3A9BF25C013D89" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU45</accession>
    <name>B8DU45_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1236</name>
    </gene>
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            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
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                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
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            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218097.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1236"/>
    <dbReference type="EnsemblBacteria" id="ACL29524">
        <property type="protein sequence ID" value="ACL29524"/>
        <property type="gene ID" value="BLA_1236"/>
    </dbReference>
    <dbReference type="GeneID" id="66533058"/>
    <dbReference type="KEGG" id="bla:BLA_1236"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1299"/>
    <dbReference type="HOGENOM" id="CLU_089225_0_0_11"/>
    <dbReference type="OMA" id="ETIFLIC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017195">
        <property type="entry name" value="ABC_thiamin-permease_prd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09819">
        <property type="entry name" value="ABC_cobalt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037394">
        <property type="entry name" value="ABC_thiamine-permease_YkoE_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="206" mass="21589" checksum="3DA7E670DEBF3C18" modified="2009-03-03" version="1">MSASVIEAKPVLKWRVVDIAVASVIGVASALIYWFVAFATAAPWSLLEGVVPGLAGIFNGLWLFAGPLAAIIVRKPGAALYAEIVAGVLEALMGNMWGGVETFLIALVQGLFAEIAFAVFAYKKWNLGVTVLSGALSGVGCWGYSFFTHLQAIDLGGSYGVVYLITTVLSGALVAGVVMWYLYLGIARTGALDQFASGRAVRGAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU58</accession>
    <name>B8DU58_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ornithine carbamoyltransferase</fullName>
            <ecNumber evidence="3">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">argF</name>
        <name evidence="10" type="ordered locus">BLA_1249</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218077.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1249"/>
    <dbReference type="EnsemblBacteria" id="ACL29537">
        <property type="protein sequence ID" value="ACL29537"/>
        <property type="gene ID" value="BLA_1249"/>
    </dbReference>
    <dbReference type="GeneID" id="66533071"/>
    <dbReference type="KEGG" id="bla:BLA_1249"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1312"/>
    <dbReference type="HOGENOM" id="CLU_043846_3_2_11"/>
    <dbReference type="OMA" id="DGNNVCN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="9">
        <location>
            <begin position="5"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="8">
        <location>
            <begin position="153"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="52"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ornithine binding" evidence="6">
        <location>
            <begin position="233"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="269"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL29537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="320" mass="35281" checksum="CBCE8F2AB2771969" modified="2009-03-03" version="1">MGELRHMLRDDDVNHEEQKQILELGMKFRADRFYHRPFEGPQGVAVIFDKPSTRTRSSFSIGVAELGGYPLVIDKSGSQLGRGEPVADTAEVLTRMAYGIVWRTFEQSRVEQMARVATVPVVNALTDEFHPCQVLADFLTLAQFKGGVDNLENLKIAYVGDAANNMSNSYLLAGAVAGMDVRVAGPNGYLPDQKIVEDAQAIAETTGGSIMVTVDPEQAVDGVDCIFTDTWVSMGEEAEYAIRSKPFWPYQVNERLMGLAKPDALFQHCLPAYRGKEVTTGVIDGPQSVVWDEAENRLHAQKALLTWLIGKQRGDESLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU69</accession>
    <name>B8DU69_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">K+ transport systems, NAD-binding component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218061.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1260"/>
    <dbReference type="EnsemblBacteria" id="ACL29548">
        <property type="protein sequence ID" value="ACL29548"/>
        <property type="gene ID" value="BLA_1260"/>
    </dbReference>
    <dbReference type="GeneID" id="66533082"/>
    <dbReference type="KEGG" id="bla:BLA_1260"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1323"/>
    <dbReference type="HOGENOM" id="CLU_046525_3_1_11"/>
    <dbReference type="OMA" id="PEYEAGC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="2">
        <location>
            <begin position="135"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="216" mass="23433" checksum="EC5A3D005334A905" modified="2009-03-03" version="1">MPENRSVLVVGLGRFGSAVATTLDALGQDVLAVDKDPELVNRWSSQIPTVQADMTDVLAIEQLNASDFDTAVVAIGDSVEASVITAGNLLDAGISDIWAKSVSKEHARILQRIGARHIINAETDAGKRVGHLVSGNYLDYIELEGAYSVVKIHTPPQFVGYTIGEAKIHDRYGVTIVGVKSPGHEFQYASNDLQLKRNDELIIMGKQDQIDHFIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU76</accession>
    <name>B8DU76_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nicotinate mononucleotide adenylyltransferase</fullName>
            <shortName evidence="6">NaMN adenylyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">nadD</name>
        <name evidence="8" type="ordered locus">BLA_1267</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NadD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18" evidence="6"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1267"/>
    <dbReference type="EnsemblBacteria" id="ACL29555">
        <property type="protein sequence ID" value="ACL29555"/>
        <property type="gene ID" value="BLA_1267"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1267"/>
    <dbReference type="HOGENOM" id="CLU_069765_1_0_11"/>
    <dbReference type="OMA" id="IHIGHLI"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00244">
        <property type="entry name" value="NaMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00482">
        <property type="entry name" value="TIGR00482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="45"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="234" mass="26255" checksum="87FA66431B553ADC" modified="2009-03-03" version="1">MNGTTPMDRSMSELSPYAQREVELVSQHGRRSARGNWHAHARIGIMGGTFDPIHNGHLVAASEVAWVYDLDEVIFVPTGRPVFKLDKHVTNEEDRYLMTVIATASNPKFVVSRVDIDRPGVTYTIDTLRDIRARYPDAELFFITGADAVAEIMRWKDAERMFDIAHFVAVTRPGYSSKVPLPAGKVDMLEIPALAISSTDVRQRARNGEPVWYLVPDGVVQYIAKHGIYDEDAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUA6</accession>
    <name>RRF_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-recycling factor</fullName>
            <shortName evidence="1">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">frr</name>
        <name type="ordered locus">BLA_1298</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269087.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DUA6"/>
    <dbReference type="SMR" id="B8DUA6"/>
    <dbReference type="STRING" id="442563.BLA_1298"/>
    <dbReference type="EnsemblBacteria" id="ACL29585">
        <property type="protein sequence ID" value="ACL29585"/>
        <property type="gene ID" value="BLA_1298"/>
    </dbReference>
    <dbReference type="GeneID" id="66533124"/>
    <dbReference type="KEGG" id="bla:BLA_1298"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1360"/>
    <dbReference type="HOGENOM" id="CLU_073981_2_0_11"/>
    <dbReference type="OMA" id="FNPMNNG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000194900" description="Ribosome-recycling factor">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <sequence length="184" mass="20218" checksum="0F1BF604F05E5920" modified="2009-03-03" version="1">MANVVDQSKEQMKKSVESTKENFAGIRTGRANPALLNGIVVEYYGAPTPLKHVATIGVPEPRTLSVTPFDPSQANAVEKALRDSDLGASPRRNGSAILLTMPELTEDRRKEYVKLAKSKAEDGKVAVRNIRRKSKEAIDKAVKDGEMGEDEGDRLLKELDKVTKATTDELDALLEAKQKEIMEV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUB2</accession>
    <name>HIS6_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Imidazole glycerol phosphate synthase subunit HisF</fullName>
            <ecNumber evidence="1">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">IGP synthase cyclase subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">IGP synthase subunit HisF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ImGP synthase subunit HisF</fullName>
            <shortName evidence="1">IGPS subunit HisF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisF</name>
        <name type="ordered locus">BLA_1304</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218001.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DUB2"/>
    <dbReference type="SMR" id="B8DUB2"/>
    <dbReference type="STRING" id="442563.BLA_1304"/>
    <dbReference type="EnsemblBacteria" id="ACL29591">
        <property type="protein sequence ID" value="ACL29591"/>
        <property type="gene ID" value="BLA_1304"/>
    </dbReference>
    <dbReference type="GeneID" id="66533130"/>
    <dbReference type="KEGG" id="bla:BLA_1304"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1366"/>
    <dbReference type="HOGENOM" id="CLU_048577_4_0_11"/>
    <dbReference type="OMA" id="IFHYKET"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01013">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000148905" description="Imidazole glycerol phosphate synthase subunit HisF">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01013"/>
        </source>
    </evidence>
    <sequence length="256" mass="27499" checksum="838A9344947CCC2F" modified="2009-03-03" version="1">MSLAVRVIPCLDVDDGRVVKGVHFENLRDAGDPVELAAEYYRQGADELTFLDVTASSSHRQTMVNVVTRTAEQIFIPLTVGGGVRTPEDVDSLLRCGADKVSVNTAAINDPTLISRVAERFGNQVLVLSVDARRERGEQHTQSGFEVTTMGGRKSTGIDALWWARRAEELGAGEVLLNSMDADGTQQGFDLEMIRAMREVVSIPIIASGGAGKAQDFPPAIAAGADAVLAASIFHYGKVTIGEVKDELRRAGYAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUB8</accession>
    <name>B8DUB8_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="15">Indole-3-glycerol phosphate synthase</fullName>
                <shortName evidence="15">IGPS</shortName>
                <ecNumber evidence="15">4.1.1.48</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="14">Tryptophan synthase beta chain</fullName>
                <ecNumber evidence="14">4.2.1.20</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="14 18" type="primary">trpB</name>
        <name evidence="15" type="synonym">trpC</name>
        <name evidence="18" type="ordered locus">BLA_1310</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 15">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 14">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7 14">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 14">Belongs to the TrpB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the TrpC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="15"/>
    <dbReference type="EC" id="4.2.1.20" evidence="14"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619996.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1310"/>
    <dbReference type="EnsemblBacteria" id="ACL29597">
        <property type="protein sequence ID" value="ACL29597"/>
        <property type="gene ID" value="BLA_1310"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1310"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1372"/>
    <dbReference type="HOGENOM" id="CLU_020620_1_0_11"/>
    <dbReference type="OMA" id="ATAGKWF"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_B">
        <property type="entry name" value="IGPS_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 15" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="9 15" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="13 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="11 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="IGPS" evidence="16">
        <location>
            <begin position="12"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="PALP" evidence="17">
        <location>
            <begin position="323"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="14">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ACL29597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="694" mass="75344" checksum="87CF3D82555CD768" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUD7</accession>
    <name>B8DUD7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1329"/>
    <dbReference type="EnsemblBacteria" id="ACL29616">
        <property type="protein sequence ID" value="ACL29616"/>
        <property type="gene ID" value="BLA_1329"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1329"/>
    <dbReference type="HOGENOM" id="CLU_691997_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WYL" evidence="2">
        <location>
            <begin position="194"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="398" mass="44435" checksum="FAAA32FBB925DC85" modified="2009-03-03" version="1">MSSAKVAAHAIDAGDEAEDEDGANGKGHKKSSFQTGSEVDRRLRLMLFLSAHMGEEYSLSELAVRFIGVPKNDDERKKFVQTIHKDINTLTTVSDDGEMAGSQFFDIDWSLLEAEGIVCATNSLGLERLAGISPQYMSMLTASVNYLAHAPLLPAEERSQAVDLYDRLRQYVEPGQTPWLSLTGYEVEPRSFGIVKKAIAEHALLDMKYTDGSGRIRERLVAPSKIYVDEGVYYVALWTDVEDVAPAALHKIVHKDMTINKETGEPRIWQILRIARIEEVQEVEPTKPMQIPDVSVSDLRKWSIETSTSAAFITDQPHLEFIRTLGDAEVEPCGEGEKVRLQIQSDSWFVAFCIAHARHILAVAPETLRTMIIARAKRELSMLDENGEADSAEEHHAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUE5</accession>
    <name>APT_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="1">APRT</shortName>
            <ecNumber evidence="1">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">apt</name>
        <name type="ordered locus">BLA_1339</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217961.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DUE5"/>
    <dbReference type="SMR" id="B8DUE5"/>
    <dbReference type="STRING" id="442563.BLA_1339"/>
    <dbReference type="EnsemblBacteria" id="ACL29624">
        <property type="protein sequence ID" value="ACL29624"/>
        <property type="gene ID" value="BLA_1339"/>
    </dbReference>
    <dbReference type="GeneID" id="66533164"/>
    <dbReference type="KEGG" id="bla:BLA_1339"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1401"/>
    <dbReference type="HOGENOM" id="CLU_063339_3_2_11"/>
    <dbReference type="OMA" id="KPGIVFR"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00103">
        <property type="entry name" value="PUR_PYR_PR_TRANSFER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0660">Purine salvage</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000116231" description="Adenine phosphoribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <sequence length="193" mass="20613" checksum="9EFE9D6D4969992C" modified="2009-03-03" version="1">MSQTDIHVANAASMSQDDARYLISLIRTVPDFPREGILFRDFMPVFADSRGLRILLDALIAALPVHTDEFDAVAGLEARGFLFGPALAAQLGKGFIAIRKAGKLPPPVHACSYALEYGKATLEIEDTSVRNNERILIVDDLIATGGSAAAAKDLIESAGGKVAGYEFVMELEGLDGRTALGDYPYGSLLKMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUE6</accession>
    <name>B8DUE6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Preprotein translocase, YajC subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yajC</name>
        <name evidence="9" type="ordered locus">BLA_1340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YajC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1340"/>
    <dbReference type="EnsemblBacteria" id="ACL29625">
        <property type="protein sequence ID" value="ACL29625"/>
        <property type="gene ID" value="BLA_1340"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1340"/>
    <dbReference type="HOGENOM" id="CLU_116157_3_1_11"/>
    <dbReference type="OMA" id="RAINKEY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33909">
        <property type="entry name" value="PTHR33909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00739">
        <property type="entry name" value="yajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="86"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="101"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL29625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="142" mass="15646" checksum="87E7F84EC707237C" modified="2009-03-03" version="1">MLIVLIVLMGVMMFYSSRKAKKQQQERQAFRTSLAPGTEVITIGGLIGKVVEVDEQYEEIVLDSEGSLLRFSLQSVSRAYVRPAYVSDDDVDENGNPLPKDEPAQITSNEPESDGSETVVEETSVVETPEDADSSPFETQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUF5</accession>
    <name>B8DUF5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217948.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1349"/>
    <dbReference type="EnsemblBacteria" id="ACL29634">
        <property type="protein sequence ID" value="ACL29634"/>
        <property type="gene ID" value="BLA_1349"/>
    </dbReference>
    <dbReference type="GeneID" id="66533174"/>
    <dbReference type="KEGG" id="bla:BLA_1349"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1411"/>
    <dbReference type="HOGENOM" id="CLU_134254_0_0_11"/>
    <dbReference type="OMA" id="MDQLLAW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="27"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="169" mass="18982" checksum="E59745C9474FA3AF" modified="2009-03-03" version="1">MVGNLVLHDISYQYTDSSEPLFDHFNASLSHGWTALLADNGLGKTTLAQLICGRRTPTRGEVQPSPRTLICAYCKQECVSEPEGLAEFRDDWFAESIALRDALGIGDDWGYRYDPLSGGERKRLQIACALYSRPDVLVLDEPTNHVDEHTRGIVVSHERWFLDEVCGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUG7</accession>
    <name>B8DUG7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulatory protein, AsnC/Lrp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_1361</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1361"/>
    <dbReference type="EnsemblBacteria" id="ACL29646">
        <property type="protein sequence ID" value="ACL29646"/>
        <property type="gene ID" value="BLA_1361"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1361"/>
    <dbReference type="HOGENOM" id="CLU_091233_1_0_11"/>
    <dbReference type="OMA" id="QTVTHYV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="176" mass="19798" checksum="CF853E20BC9F2E44" modified="2009-03-03" version="1">MTGDMAEGNISANDQAILELLENDARLDARDLADILGEEAQEVQQAVRRMEEQKIICGYHTVINYNKVLRDERIMAFIEVEVSPMKGKGYDHTAALLAKYPEIDSLYLITGDNDFICLVQGKTMFEVCQFVADRIAVMENVQSTKTLFVLKQYKQSGILTGAGRPNRAEDRLVVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUJ3</accession>
    <name>B8DUJ3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix, HxlR type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217896.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1387"/>
    <dbReference type="EnsemblBacteria" id="ACL29672">
        <property type="protein sequence ID" value="ACL29672"/>
        <property type="gene ID" value="BLA_1387"/>
    </dbReference>
    <dbReference type="GeneID" id="66533217"/>
    <dbReference type="KEGG" id="bla:BLA_1387"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1451"/>
    <dbReference type="HOGENOM" id="CLU_111585_2_0_11"/>
    <dbReference type="OMA" id="CPTNQLL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="114" mass="13026" checksum="CA966EB2504F251F" modified="2009-03-03" version="1">MEKLDIFAKDCPARFPLQVISGKWGLLVILALEKKPLRFSELVHNIGGISERMASQTLKYLEQIGVVRREVLQRSKPPQVYYELTSLGRRFLKPLGELVETVSAHVDTMAYRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUJ5</accession>
    <name>B8DUJ5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1389"/>
    <dbReference type="EnsemblBacteria" id="ACL29674">
        <property type="protein sequence ID" value="ACL29674"/>
        <property type="gene ID" value="BLA_1389"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1389"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1453"/>
    <dbReference type="HOGENOM" id="CLU_013985_34_1_11"/>
    <dbReference type="OMA" id="IAGFDGW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017255">
        <property type="entry name" value="AcTrfase_GNAT_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037663">
        <property type="entry name" value="Acetyltransf_GNAT_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="145" mass="15893" checksum="ACFA30C3271A2C49" modified="2009-03-03" version="1">MIRPMTIDDYDAVCACCMSCTGMGLNTIDDSRDGIAKYLARNPTTCFVDERDGRITGVIIAGHDGRRGYIYHTAVSPDHRHQGIGTALVEAALHALTDEGIAKVALVVFARNADGNAFWQRLGFTSRDDLTYRNKALAELTRIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUJ7</accession>
    <name>B8DUJ7_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dihydroorotate dehydrogenase</fullName>
            <shortName evidence="9">DHOD</shortName>
            <shortName evidence="9">DHODase</shortName>
            <shortName evidence="9">DHOdehase</shortName>
            <ecNumber evidence="9">1.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">pyrD</name>
        <name evidence="12" type="ordered locus">BLA_1391</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of dihydroorotate to orotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-dihydroorotate + A = AH2 + orotate</text>
            <dbReference type="Rhea" id="RHEA:18073"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="9">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.3.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1391"/>
    <dbReference type="EnsemblBacteria" id="ACL29676">
        <property type="protein sequence ID" value="ACL29676"/>
        <property type="gene ID" value="BLA_1391"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1391"/>
    <dbReference type="HOGENOM" id="CLU_042042_0_0_11"/>
    <dbReference type="OMA" id="SCPHAKG"/>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04740">
        <property type="entry name" value="DHOD_1B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00224">
        <property type="entry name" value="DHO_dh_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033888">
        <property type="entry name" value="DHOD_1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024920">
        <property type="entry name" value="Dihydroorotate_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01037">
        <property type="entry name" value="pyrD_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 9" id="KW-0288">FMN</keyword>
    <keyword evidence="8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="11">
        <location>
            <begin position="29"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="90"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="212"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="66"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="264"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACL29676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="324" mass="34302" checksum="50C70F7BDC53A9EA" modified="2009-03-03" version="1">MDERAKENETMNETTSSVYEPHEWKHGTVVAGIPWRNPVGTASGTFQVDACGQFYDVSQLGAVTTKGVSPVPWLGNPGVRTAECPAGTVNAVGLQNPGVDHYLEYDLPKLKNMGATVVSNVAGHCDDDYAQVVAKLADSDADMLEINVSCPNVTHGGMSVGTDPMALSRLMERLRPMTDKPMIVKLTPNVTDITAIAKAAVESGADALSMINTLVGMRINIKTGEPIIANRTGGVSGPAVFPVGLACVWRVRTALPDVPIIGIGGIDSGEKALEYLYAGANAVEVGGAALYDPTAPIRVARELDDLLDSRPQLAHKLVKGDTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUQ5</accession>
    <name>B8DUQ5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Permeases of the major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1450"/>
    <dbReference type="EnsemblBacteria" id="ACL29734">
        <property type="protein sequence ID" value="ACL29734"/>
        <property type="gene ID" value="BLA_1450"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1450"/>
    <dbReference type="HOGENOM" id="CLU_133285_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="136" mass="14359" checksum="F152E88E797A29C4" modified="2009-03-03" version="1">MPRPWVMAGVAVQCVVFLTAGIRSHDLWPFVCACFGLVGAVGVQLSLAMAIPRHALGLGDVTASGMAGFATGYFGLECYLWFWLCMGVLGVGWVPAYSVYSRVRSRGRTGDGVGRLRVPFVPVIATAAALAVMCCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUR0</accession>
    <name>B8DUR0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate/bisphosphoglycerate mutase</fullName>
            <ecNumber evidence="1">5.4.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.2.-" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217812.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1456"/>
    <dbReference type="EnsemblBacteria" id="ACL29739">
        <property type="protein sequence ID" value="ACL29739"/>
        <property type="gene ID" value="BLA_1456"/>
    </dbReference>
    <dbReference type="GeneID" id="66533286"/>
    <dbReference type="KEGG" id="bla:BLA_1456"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1523"/>
    <dbReference type="HOGENOM" id="CLU_033323_9_0_11"/>
    <dbReference type="OMA" id="FREQCYG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="225" mass="24845" checksum="536AFCF9A4AEE699" modified="2009-03-03" version="1">MIVHVHLVRHGQTFFNRYNRLQGWSNSPLTQAGLDDAIHAGNALKDITFAAAYCSDTTRAQVTAQTILDINAANGHDVPVIHADMHFREQFYGYFEGQDMGAAWLAAGGPHGAPTYHAIVEQFGLGATRDFLKEADPFHDAESDEEYWRRVDGAFALIAANADLRDGDDVLMISHGNTLLSLMQRFAPAGYDLSERPANGSVTMIDFDTVKSLDDAIEVISYNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUR3</accession>
    <name>B8DUR3_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pcrA</name>
        <name evidence="10" type="ordered locus">BLA_1459</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014483170.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1459"/>
    <dbReference type="EnsemblBacteria" id="ACL29742">
        <property type="protein sequence ID" value="ACL29742"/>
        <property type="gene ID" value="BLA_1459"/>
    </dbReference>
    <dbReference type="GeneID" id="66533289"/>
    <dbReference type="KEGG" id="bla:BLA_1459"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1526"/>
    <dbReference type="HOGENOM" id="CLU_004585_3_1_11"/>
    <dbReference type="OMA" id="YQDTNRT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="8">
        <location>
            <begin position="17"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="9">
        <location>
            <begin position="329"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="730"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL29742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="907" mass="100123" checksum="45FB3D481739FF9E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUS4</accession>
    <name>B8DUS4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein GntR, HTH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217790.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29753">
        <property type="protein sequence ID" value="ACL29753"/>
        <property type="gene ID" value="BLA_1471"/>
    </dbReference>
    <dbReference type="GeneID" id="66533301"/>
    <dbReference type="KEGG" id="bla:BLA_1471"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1539"/>
    <dbReference type="HOGENOM" id="CLU_017584_10_4_11"/>
    <dbReference type="OMA" id="IFEMFSI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="139" mass="15156" checksum="82B45744EB807423" modified="2009-03-03" version="1">MQLLISTTSMTPIYEQIVDQIRALIKEGRLKAGEPLDSVRSLARTCRISALTVKKAYDVLEREGLVVTVQGKGSFVAQISPNIVAEELNRQVEEQFAQAIAKARRLGLTREEILELVVMLLEDTSADSGDAPEGTEGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUS8</accession>
    <name>B8DUS8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chorismate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217786.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1475"/>
    <dbReference type="EnsemblBacteria" id="ACL29757">
        <property type="protein sequence ID" value="ACL29757"/>
        <property type="gene ID" value="BLA_1475"/>
    </dbReference>
    <dbReference type="GeneID" id="66533305"/>
    <dbReference type="KEGG" id="bla:BLA_1475"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1543"/>
    <dbReference type="HOGENOM" id="CLU_131518_2_2_11"/>
    <dbReference type="OMA" id="WECADMS"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="101" mass="11374" checksum="66CE258266CBD7DE" modified="2009-03-03" version="1">MQCNSLDEVRSHIDAIDDQTIALIGGRGQYAVQASAFKKDEEGVRDTNRMERVIAKVRGKAERCGANPDVVEAIYREIISRFINMEMREFHDHPSPTPAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUT4</accession>
    <name>B8DUT4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transposase, IS4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BLA_1481</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the transposition of the insertion sequence IS5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29763">
        <property type="protein sequence ID" value="ACL29763"/>
        <property type="gene ID" value="BLA_1481"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1481"/>
    <dbReference type="HOGENOM" id="CLU_049873_1_2_11"/>
    <dbReference type="OMA" id="VEHIFGF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008490">
        <property type="entry name" value="Transposase_InsH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05598">
        <property type="entry name" value="DUF772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="DUF772" evidence="6">
        <location>
            <begin position="51"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="5">
        <location>
            <begin position="137"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="325" mass="36603" checksum="7BE329CCD434A2D6" modified="2009-03-03" version="1">MDKQMTISAFSDELAQVRTKKKAFLDQIERIVPWKEWLAMIQPCYYKGERGNKPYPLEIMLRLYLLQNLYDLSDEATVAEAIDSRAFSEFCGVDSSNQVPNGDTLGRFRNLLIKNGLQEKLFAQVVAALMERGLILKKGTIVDSTIISAPSSTKNKEKKRDPDAHQVKKGNTWHFGYKAHIGVDKDSGLVHTVEATPANVHDVAEVPKLLTGEEETVYGDSGYLGAGKREDAVVRNKAGRKIKYKINRRPSQMKKLSKSGQYAAKKAERAKSSVRAKVEHVFGVVKKQLRFRKTRYRGLEKQQAKFNIMFALANLILADRPCLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUU6</accession>
    <name>B8DUU6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible NTP pyrophosphatase in MutT family</fullName>
            <ecNumber evidence="2">3.6.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.13" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217753.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1493"/>
    <dbReference type="EnsemblBacteria" id="ACL29775">
        <property type="protein sequence ID" value="ACL29775"/>
        <property type="gene ID" value="BLA_1493"/>
    </dbReference>
    <dbReference type="GeneID" id="66533324"/>
    <dbReference type="KEGG" id="bla:BLA_1493"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1562"/>
    <dbReference type="HOGENOM" id="CLU_062658_3_0_11"/>
    <dbReference type="OMA" id="DYQVHPG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="54"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="209" mass="23830" checksum="0C6C3E0F2075ACD7" modified="2009-03-03" version="1">MSKQTYRRFDPWRSTPIQEEARETIVGGHYFNIDRVSLTSPTVGHFERLILHKNNGDSVGVIGLTKDGRVPLIEQYRIPVHRWTLEIPAGHAVDKGERPIDVAHRKLAEEVGYKAGVMTQFCRFINTPSYSTQHTALYFAYDLEPIDEREQYANEARAQVRFLTPQECYELVLNGTILDAKSIIAIQRLYMAPNHMIGVSPYDGAPARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUW9</accession>
    <name>B8DUW9_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonine ammonia-lyase</fullName>
            <ecNumber evidence="4">4.3.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ilvA</name>
        <name evidence="7" type="ordered locus">BLA_1516</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="4"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1516"/>
    <dbReference type="EnsemblBacteria" id="ACL29798">
        <property type="protein sequence ID" value="ACL29798"/>
        <property type="gene ID" value="BLA_1516"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1516"/>
    <dbReference type="HOGENOM" id="CLU_021152_4_1_11"/>
    <dbReference type="OMA" id="LIHPFDH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04886">
        <property type="entry name" value="ACT_ThrD-II-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044561">
        <property type="entry name" value="ACT_ThrD-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005789">
        <property type="entry name" value="Thr_deHydtase_catblc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01127">
        <property type="entry name" value="ilvA_1Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="6">
        <location>
            <begin position="339"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="415" mass="44478" checksum="A4C136953443846E" modified="2009-03-03" version="1">MQAMRRDHAAELKMAAERLEGTAKHTQIIASPVLSEMTGHTILLKPENLQVTGSFKIRGAYNKIASLTDEELERGIVTASAGNHAQGVAYAAHERGAKATILMPEITPPLKVDATKAYGADVVLHGDVFDEAAAYAIELSQREGMIYVPPFDDYEVLCGQGTIAMEILEDVPGVTDIVVPLGGGGLGAGVALAVKMFRPEVRVIGAIPEGSPAFRRSFDAGHVVPADKVVTSAEGVAVRRPGDLTFALLNEFLDDLVEVSERDINEMILLMLEKHKMVVEAAGAVSLAALEHLNLRSRKFAEAPGEHVVVPIMSGGNIDTVTIGAVIQKGMIARGRIMNFEVELPDTPGQLVKVATILAKARANVIALDHDQFKANGHYTNSVALGVTVETNGPDHIEQVMQMLRDAGYSPKRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUZ3</accession>
    <name>B8DUZ3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_1540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1540"/>
    <dbReference type="EnsemblBacteria" id="ACL29822">
        <property type="protein sequence ID" value="ACL29822"/>
        <property type="gene ID" value="BLA_1540"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1540"/>
    <dbReference type="HOGENOM" id="CLU_1318829_0_0_11"/>
    <dbReference type="OMA" id="HMHERQA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867634" evidence="2">
        <location>
            <begin position="36"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="3">
        <location>
            <begin position="62"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="187" mass="19969" checksum="04F5DE0AB0E538D9" modified="2009-03-03" version="1">MFAVVGAVLVVALFISSLFLFHVGGLGEVKTTAEGADHGVVAPCVSPAEDGSKPKYLDSKSVTTRVLNGTKFSGFANAVGRALQNREFVVQSIDNYDNAKVERTTIVFGKNAIPQAYTLAANFPDAQLQMDDRQDKLVDVILGATFQNLTKTDELPKTGSEIPNIEGCKPANDMKDLPKAPEHTSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUZ7</accession>
    <name>B8DUZ7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Virulence factor MVIN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BLA_1544</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1544"/>
    <dbReference type="EnsemblBacteria" id="ACL29826">
        <property type="protein sequence ID" value="ACL29826"/>
        <property type="gene ID" value="BLA_1544"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1544"/>
    <dbReference type="HOGENOM" id="CLU_004442_0_0_11"/>
    <dbReference type="OMA" id="QPRHENN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1087"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="490"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1013"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1048"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1132"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="523"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1058"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1142"/>
            <end position="1160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL29826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="1277" mass="137063" checksum="E3314475EC46457E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV03</accession>
    <name>B8DV03_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Membrane protein insertase YidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Foldase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Membrane integrase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Membrane protein YidC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">oxaA</name>
        <name evidence="16" type="ordered locus">BLA_1550</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219010.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1550"/>
    <dbReference type="EnsemblBacteria" id="ACL29832">
        <property type="protein sequence ID" value="ACL29832"/>
        <property type="gene ID" value="BLA_1550"/>
    </dbReference>
    <dbReference type="GeneID" id="66533948"/>
    <dbReference type="KEGG" id="bla:BLA_1550"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1629"/>
    <dbReference type="HOGENOM" id="CLU_036138_3_1_11"/>
    <dbReference type="OMA" id="ERYKNDR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="274"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="280"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ACL29832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="336" mass="38664" checksum="955BFDC220481356" modified="2009-03-03" version="1">MNSENFLLDAGIWGFVYKILTPIEWLMTWVMWVFHKLFTFIGMPEHGISWALAIIFLVIVVQACVFPLYYKSMKGMRAMQAMQPKMMKIQNKYKGKNDPASKEAMQREMMKLYKDNNANPAGSCLPMLLQGPVFMCMFYVLSAIPYIARGKRSPLGAFDVATAESFSQSTYFGVKITDSFTTATTTGKVVIGIFVALMCACLWYMQFYSMRRNTAPASVNRQSQMMQKAMLWVFPIMYIFSGVAMPFAVLIYWLANNICNLLRTMWQVHEFPTPGSPAAEAKEIRDHDNENKKREKEGRPSLEEEELIKAKQEAESRVTQGFQREQPKRKNRGRKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV06</accession>
    <name>DNAA_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dnaA</name>
        <name type="ordered locus">BLA_0001</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DnaA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219016.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DV06"/>
    <dbReference type="SMR" id="B8DV06"/>
    <dbReference type="STRING" id="442563.BLA_0001"/>
    <dbReference type="EnsemblBacteria" id="ACL28307">
        <property type="protein sequence ID" value="ACL28307"/>
        <property type="gene ID" value="BLA_0001"/>
    </dbReference>
    <dbReference type="GeneID" id="66532374"/>
    <dbReference type="KEGG" id="bla:BLA_0001"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1"/>
    <dbReference type="HOGENOM" id="CLU_026910_2_2_11"/>
    <dbReference type="OMA" id="FPAFKIV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018312">
        <property type="entry name" value="Chromosome_initiator_DnaA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01008">
        <property type="entry name" value="DNAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000189782" description="Chromosomal replication initiator protein DnaA">
        <location>
            <begin position="1"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="277"/>
            <end position="284"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="583" mass="64801" checksum="4EDA0431A1861F57" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV08</accession>
    <name>B8DV08_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">DNA replication and repair protein RecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">recF</name>
        <name evidence="10" type="ordered locus">BLA_0003</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the RecF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219019.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0003"/>
    <dbReference type="EnsemblBacteria" id="ACL28309">
        <property type="protein sequence ID" value="ACL28309"/>
        <property type="gene ID" value="BLA_0003"/>
    </dbReference>
    <dbReference type="GeneID" id="66532376"/>
    <dbReference type="KEGG" id="bla:BLA_0003"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.3"/>
    <dbReference type="HOGENOM" id="CLU_040267_1_1_11"/>
    <dbReference type="OMA" id="GESWSYA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00365">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001238">
        <property type="entry name" value="DNA-binding_RecF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018078">
        <property type="entry name" value="DNA-binding_RecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042174">
        <property type="entry name" value="RecF_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32182:SF0">
        <property type="entry name" value="PTHR32182:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00611">
        <property type="entry name" value="recf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00617">
        <property type="entry name" value="RECF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="SMC_N" evidence="9">
        <location>
            <begin position="4"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="431"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL28309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="475" mass="51827" checksum="589BCB8AF9DD418C" modified="2009-03-03" version="1">MITVSRLALDHFRSWTNCVLDFKPGVNILEGPNGLGKTNIVEALEVLSTGSSHRASTSQPLVEQGFPAAAIRANIEELSEDFENNTETIDDRTTTFELTIRVRGANRARVDGGPSLYMRDIVGRVPLVAFTPDDQRLVWGDPAVRRSFIDQAASVLVRGYTDLLQRFTHIAKQRAALLKQIGAQEGVSVSEEARQMRMNGLEVWTAQFIETGLELTRQRMAVIGMLNEYFGTIVQELSDVDQTATLVYEPSFDELYLTQGAEAGEQGGPERVKAAISEHFQRIYTGEVARGVNLIGPQRDDVSIELNGMPAREYSSNGESWTLALALKMALYRLLERKAGERPIVVLDDVFAQLDPSRRAKIMEFALRQDQVIITVAAAGDVPELPGDAHAHVIDVAALKLQGSGGEGTAFMPEPLPADDPFAGQLAAVQASRRTAGMHAGSDGKHKVEQSADQSAEQVSGEREIGLTKHESAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV24</accession>
    <name>B8DV24_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219048.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0020"/>
    <dbReference type="EnsemblBacteria" id="ACL28325">
        <property type="protein sequence ID" value="ACL28325"/>
        <property type="gene ID" value="BLA_0020"/>
    </dbReference>
    <dbReference type="GeneID" id="66532395"/>
    <dbReference type="KEGG" id="bla:BLA_0020"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.21"/>
    <dbReference type="HOGENOM" id="CLU_088936_0_0_11"/>
    <dbReference type="OMA" id="PVWRECA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="63"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="251" mass="28232" checksum="951C199062FF288C" modified="2009-03-03" version="1">MDYQSENAQTIDRWVDEGWQWGVPISHDAFVDAQHGSWNILLTPTKPVPHEWVGDVRGKRVLGLASGGAQQMPVMAALGAQCTVLDYSSRQCEREYEVADREGYDIEVIQADMTQPLPFADESFDLIINPVSNCYIEQVKPVFRECYRVLKPGGSLIGGYDNGINYIFDNEETTLTYALPFNPLHDERARQLLLDEDAGMQFSHTLDEQIGGQLEAGFTLRALYEDTNGEGNLHEHHVPTFVATWSVKPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV89</accession>
    <name>B8DV89_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BLA_0087</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0410 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218384.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28390">
        <property type="protein sequence ID" value="ACL28390"/>
        <property type="gene ID" value="BLA_0087"/>
    </dbReference>
    <dbReference type="GeneID" id="66532462"/>
    <dbReference type="KEGG" id="bla:BLA_0087"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.92"/>
    <dbReference type="HOGENOM" id="CLU_160040_4_0_11"/>
    <dbReference type="OMA" id="HEMPGGI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007341">
        <property type="entry name" value="Transgly_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33884">
        <property type="entry name" value="PTHR33884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04226">
        <property type="entry name" value="Transgly_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="84" mass="8553" checksum="F84EE6CF3FB2B080" modified="2009-03-03" version="1">MHWLWVLIVGAIIGAIAGAITHHSGAMGRISNIIAGLVGSALGEALLGHWGPQLAGMAIIPSLIGAIVVVAVVSFFLMRSSAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVD1</accession>
    <name>B8DVD1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sucrose phosphorylase</fullName>
            <ecNumber evidence="7">2.4.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">scrP</name>
        <name evidence="7" type="ordered locus">BLA_0129</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family. Sucrose phosphorylase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.7" evidence="7"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218429.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="SMR" id="B8DVD1"/>
    <dbReference type="STRING" id="442563.BLA_0129"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28432">
        <property type="protein sequence ID" value="ACL28432"/>
        <property type="gene ID" value="BLA_0129"/>
    </dbReference>
    <dbReference type="GeneID" id="66532504"/>
    <dbReference type="KEGG" id="bla:BLA_0129"/>
    <dbReference type="HOGENOM" id="CLU_021358_1_0_11"/>
    <dbReference type="OMA" id="PNATQFT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009018">
        <property type="term" value="F:sucrose phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044262">
        <property type="term" value="P:cellular carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11355">
        <property type="entry name" value="AmyAc_Sucrose_phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015325">
        <property type="entry name" value="Suc_Porlyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016377">
        <property type="entry name" value="Sucrose_GGa_phosphorylase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022527">
        <property type="entry name" value="Sucrose_phospho"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09244">
        <property type="entry name" value="DUF1964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003059">
        <property type="entry name" value="Sucrose_phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03852">
        <property type="entry name" value="sucrose_gtfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="6">
        <location>
            <begin position="6"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>sucrose</name>
            <dbReference type="ChEBI" id="CHEBI:17992"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>sucrose</name>
            <dbReference type="ChEBI" id="CHEBI:17992"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="190"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>sucrose</name>
            <dbReference type="ChEBI" id="CHEBI:17992"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>sucrose</name>
            <dbReference type="ChEBI" id="CHEBI:17992"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="289"/>
            <end position="290"/>
        </location>
        <ligand>
            <name>sucrose</name>
            <dbReference type="ChEBI" id="CHEBI:17992"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="342"/>
            <end position="345"/>
        </location>
        <ligand>
            <name>sucrose</name>
            <dbReference type="ChEBI" id="CHEBI:17992"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>sucrose</name>
            <dbReference type="ChEBI" id="CHEBI:17992"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR003059-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR003059-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL28432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="506" mass="56156" checksum="7ACB7DAF815C210D" modified="2009-03-03" version="1">MKNKVQLITYADRLGDGNLASMTDILRTRFDGVYEGVHILPFFTPFDGADAGFDPIDHTKVDARLGDWDDIAELAKTHDIMVDAIVNHMSWQSKQFQDVLANGEDSEYYPMFLTMSSVFPDGATEEELAGIYRPRPGLPFTHYSFAGKTRLVWVTFTPQQVDIDTDSAKGWEYLMSIFDQMSKSHVKYIRLDAVGYGAKEAGTSCFMTPKTFELISRLREEGAKRGLEILIEVHSYYKKQVEIAAKVDRVYDFALPPLLLHSLFTGKVDALAHWTEIRPNNAVTVLDTHDGIGVIDIGSDQLDRSLKGLVPDADVDNMVETIAKNTHGESKAATGAAASNLDLYQVNSTYYSALGCNDQHYIAARAVQFFLPGVPQVYYVGALAGENDMELLKRTNVGRDINRHYYTTSEIDKNLERPVVKALNALARFRNELPAFDGDFSYSVGDDESIAFSWNGFGSSATLTFTPSKGMGVENPQSVATLVWTDSTGEHRTDDLIANPPVMQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVE6</accession>
    <name>B8DVE6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218451.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0144"/>
    <dbReference type="EnsemblBacteria" id="ACL28447">
        <property type="protein sequence ID" value="ACL28447"/>
        <property type="gene ID" value="BLA_0144"/>
    </dbReference>
    <dbReference type="GeneID" id="66532519"/>
    <dbReference type="KEGG" id="bla:BLA_0144"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.152"/>
    <dbReference type="HOGENOM" id="CLU_081578_2_1_11"/>
    <dbReference type="OMA" id="RRIGTNF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006938">
        <property type="entry name" value="DUF624"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04854">
        <property type="entry name" value="DUF624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="211" mass="23085" checksum="E8E894B4767B90E4" modified="2009-03-03" version="1">MIAGGIFRQDNPYNTVMNRIGDIAMLSVAWFVCCLPVVTIGVSTAAACEVAREMQEDRDNGIFKGFWRAIKRRFGTGMLLTLFLGVLIALGAFDLWWISRSMAGDMASVLYGVTLAVFIIVAMLFAFLLPLSGRSKLSAGEQIKQSAKLATMKPFIALVVAAIYALPIVLLATLPSAVMWVPLVWCIFGGGASAWAQMWLIRRAFDLQPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVH6</accession>
    <name>B8DVH6_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dipeptidase</fullName>
            <ecNumber evidence="4">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pepDB</name>
        <name evidence="5" type="ordered locus">BLA_0175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the peptidase C69 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268977.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="MEROPS" id="C69.001"/>
    <dbReference type="EnsemblBacteria" id="ACL28477">
        <property type="protein sequence ID" value="ACL28477"/>
        <property type="gene ID" value="BLA_0175"/>
    </dbReference>
    <dbReference type="GeneID" id="66532551"/>
    <dbReference type="KEGG" id="bla:BLA_0175"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.185"/>
    <dbReference type="HOGENOM" id="CLU_014823_4_1_11"/>
    <dbReference type="OMA" id="TWYGQKL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="PTHR12994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
        <property type="entry name" value="Peptidase_C69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="522" mass="57906" checksum="24964606CE43CC8F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVJ0</accession>
    <name>B8DVJ0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28491">
        <property type="protein sequence ID" value="ACL28491"/>
        <property type="gene ID" value="BLA_0189"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0189"/>
    <dbReference type="HOGENOM" id="CLU_3230228_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="43" mass="4942" checksum="95E91E113F4241D8" modified="2009-03-03" version="1">MHRFVISADCPHDKPVHSRAYLPYEIADSSFGALQADTPWRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVK9</accession>
    <name>B8DVK9_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">BLA_0208</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0208"/>
    <dbReference type="CAZy" id="GT51">
        <property type="family name" value="Glycosyltransferase Family 51"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28510">
        <property type="protein sequence ID" value="ACL28510"/>
        <property type="gene ID" value="BLA_0208"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0208"/>
    <dbReference type="HOGENOM" id="CLU_006354_6_2_11"/>
    <dbReference type="OMA" id="LAQMAMI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867648" description="Peptidoglycan glycosyltransferase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="12">
        <location>
            <begin position="102"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="11">
        <location>
            <begin position="366"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="658"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="677"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACL28510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="805" mass="85605" checksum="B38493E8BEB4DC9E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVL2</accession>
    <name>B8DVL2_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA topoisomerase 1</fullName>
            <ecNumber evidence="8">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">topA</name>
        <name evidence="11" type="ordered locus">BLA_0211</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="8"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219309.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0211"/>
    <dbReference type="EnsemblBacteria" id="ACL28513">
        <property type="protein sequence ID" value="ACL28513"/>
        <property type="gene ID" value="BLA_0211"/>
    </dbReference>
    <dbReference type="GeneID" id="66532585"/>
    <dbReference type="KEGG" id="bla:BLA_0211"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.224"/>
    <dbReference type="HOGENOM" id="CLU_002929_2_0_11"/>
    <dbReference type="OMA" id="YAQPKQR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03363">
        <property type="entry name" value="TOPRIM_TopoIA_TopoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005733">
        <property type="entry name" value="TopoI_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025589">
        <property type="entry name" value="Toprim_C_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034149">
        <property type="entry name" value="TOPRIM_TopoI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13368">
        <property type="entry name" value="Toprim_C_rpt"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01051">
        <property type="entry name" value="topA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="10">
        <location>
            <begin position="5"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="8">
        <location>
            <begin position="176"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="828"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="892"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="923"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL28513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="986" mass="107165" checksum="E46E6915BDCAF539" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVL7</accession>
    <name>B8DVL7_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dipeptidase</fullName>
            <ecNumber evidence="4">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pepD</name>
        <name evidence="5" type="ordered locus">BLA_0216</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the peptidase C69 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219304.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="MEROPS" id="C69.001"/>
    <dbReference type="EnsemblBacteria" id="ACL28518">
        <property type="protein sequence ID" value="ACL28518"/>
        <property type="gene ID" value="BLA_0216"/>
    </dbReference>
    <dbReference type="GeneID" id="66532590"/>
    <dbReference type="KEGG" id="bla:BLA_0216"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.229"/>
    <dbReference type="HOGENOM" id="CLU_014823_4_1_11"/>
    <dbReference type="OMA" id="DLTYSHE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="PTHR12994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
        <property type="entry name" value="Peptidase_C69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="541" mass="60591" checksum="FCB4F7476D7875E8" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVN6</accession>
    <name>B8DVN6_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycerol-3-phosphate dehydrogenase [NAD(P)+]</fullName>
            <ecNumber evidence="7">1.1.1.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(P)H-dependent glycerol-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gpsA</name>
        <name evidence="16" type="ordered locus">BLA_0235</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:11096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7 13">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 11">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.94" evidence="7"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268319.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0235"/>
    <dbReference type="EnsemblBacteria" id="ACL28537">
        <property type="protein sequence ID" value="ACL28537"/>
        <property type="gene ID" value="BLA_0235"/>
    </dbReference>
    <dbReference type="GeneID" id="66532611"/>
    <dbReference type="KEGG" id="bla:BLA_0235"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.250"/>
    <dbReference type="HOGENOM" id="CLU_033449_0_2_11"/>
    <dbReference type="OMA" id="NRMFGNM"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004367">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00394">
        <property type="entry name" value="NAD_Glyc3P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7 13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_Gly3P_dh_N" evidence="14">
        <location>
            <begin position="3"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_Gly3P_dh_C" evidence="15">
        <location>
            <begin position="181"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="256"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ACL28537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="332" mass="34460" checksum="0B8D8B485DB8163A" modified="2009-03-03" version="1">MANVTVLGAGAWGTAFGQVLADAGNDVMMWAIEPEIVKAIQTEHRNPVRLPSVEKLPDNMKATGDRAEAVAHADVVVVAIAAQYARGALEEFKGLIPDSALIVSLMKGIEKSTGKRMDQVVCEALDLPTQRFAAVSGPNLSKQIAARQPAATVIGCTDIDNARMMANLCTTDYFKAFITADVIGLELCGSLKNVVALAVGMSHGAGYGENTAAMIETRGLAELTAVGTAAGALPETFHGLAGVGDLIATCGSPLSRNYTFGFNLGKGMSVAEATKASDGVAEGVATASAVVELGEKYHVDTPLAKAVTRVLDDGISFSQMVSEMFPQGITVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVT3</accession>
    <name>B8DVT3_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ribonuclease</fullName>
            <ecNumber evidence="12">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">BLA_0282</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 12">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the RNase HII family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="12"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268411.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0282"/>
    <dbReference type="EnsemblBacteria" id="ACL28584">
        <property type="protein sequence ID" value="ACL28584"/>
        <property type="gene ID" value="BLA_0282"/>
    </dbReference>
    <dbReference type="GeneID" id="66532659"/>
    <dbReference type="KEGG" id="bla:BLA_0282"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.300"/>
    <dbReference type="HOGENOM" id="CLU_036532_3_0_11"/>
    <dbReference type="OMA" id="DGKHDYL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07182">
        <property type="entry name" value="RNase_HII_bacteria_HII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF18">
        <property type="entry name" value="PTHR10954:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10 12 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_HII" evidence="13">
        <location>
            <begin position="20"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_HII" evidence="13">
        <location>
            <begin position="183"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACL28584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="258" mass="27689" checksum="5F0D54313CC3A2EF" modified="2009-03-03" version="1">MAPSFALERQIAADGFDVIVGFDEVGRGSLAGPVMVGAAAFLARNLDEAQTAMPQYLADSKTLTEHRRESLYEPLQAWVDGFAIGSASNAEIDAWGISHALGIAALRALDGVERALGMGSPGDSEIRGFDERCKYSGTWAYTKHSPQQHADGLHVGAILDGPNDYISKALGTFEAPAVPMPAQVRTLVKADAQCASVAAAAVLAKVTRDRLMEQLARDHAEYARYGWERNKGYGSKAHREAIAQCGPSDLHRVSWHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVV1</accession>
    <name>B8DVV1_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin carboxylase</fullName>
            <ecNumber evidence="2">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">jadJ</name>
        <name evidence="11" type="ordered locus">BLA_0300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268445.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0300"/>
    <dbReference type="EnsemblBacteria" id="ACL28602">
        <property type="protein sequence ID" value="ACL28602"/>
        <property type="gene ID" value="BLA_0300"/>
    </dbReference>
    <dbReference type="GeneID" id="66532678"/>
    <dbReference type="KEGG" id="bla:BLA_0300"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.320"/>
    <dbReference type="HOGENOM" id="CLU_000395_3_6_11"/>
    <dbReference type="OMA" id="HEIQVTC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="10">
        <location>
            <begin position="4"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="123"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="531"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="505"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL28602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="624" mass="68142" checksum="D315CF8A474BE0B2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVW7</accession>
    <name>B8DVW7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BLA_0316</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenosine + H(+) + H2O = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:24409"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosine + phosphate = adenine + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27642"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:27643"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27646"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:27647"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:11853"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0316"/>
    <dbReference type="EnsemblBacteria" id="ACL28618">
        <property type="protein sequence ID" value="ACL28618"/>
        <property type="gene ID" value="BLA_0316"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0316"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.339"/>
    <dbReference type="HOGENOM" id="CLU_065784_3_2_11"/>
    <dbReference type="OMA" id="CICGDCY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16833">
        <property type="entry name" value="YfiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003730">
        <property type="entry name" value="Cu_polyphenol_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038371">
        <property type="entry name" value="Cu_polyphenol_OxRdtase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011324">
        <property type="entry name" value="Cytotoxic_necrot_fac-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30616">
        <property type="entry name" value="PTHR30616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02578">
        <property type="entry name" value="Cu-oxidase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64438">
        <property type="entry name" value="SSF64438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL28618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="363" mass="39216" checksum="8AB5930D16D1A287" modified="2009-03-03" version="1">MEQEDKAAREGGKDADGKTYDDAILDSSAIEPTDDEGNPIPVTIPVVLSPGITVIYTTRLGGVSAEEWAHFNLGGKSGDDPVAVERNREALADELHVKLSLIDQVHSGKSVDIDEVYTENKPFGFDASGSHTEAQAKAKRAGEPVVDDVESENAEVQVIEGDAQVTCRKDIAIGVFAADCLPVLFADPQAGVVAAAHCGRKGLQRNVIAATVDMMVKKGASKENIVATLGPAICGDCYEVGDQIADEFDAQFPGTFTLTRFGGPGIDLNKAALMELHQAGIKDDRIFSSQPRVNAATQYLSQDAELEELCREDNEGDPALEERIKGIRYSMCTLENPLWFSHRRAELAHKRHEGRMLALIVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW01</accession>
    <name>B8DW01_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Possible 2-hydroxyacid dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.95</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="4"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268550.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0350"/>
    <dbReference type="EnsemblBacteria" id="ACL28652">
        <property type="protein sequence ID" value="ACL28652"/>
        <property type="gene ID" value="BLA_0350"/>
    </dbReference>
    <dbReference type="GeneID" id="66532733"/>
    <dbReference type="KEGG" id="bla:BLA_0350"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.376"/>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_11"/>
    <dbReference type="OMA" id="KHGAWQQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="2">
        <location>
            <begin position="37"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="3">
        <location>
            <begin position="130"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="335" mass="36488" checksum="B36B93DC61E7DFA2" modified="2009-03-03" version="1">MTQILETQPERTDLPLTVMPCVVADMIEPFKANFEVLRDVTRLRMYTDTTLDPDEIVRRCEGADAVIVIGVHIDDNLYTRLTHTQGHAKCFAFGGTGVASYIDLARARQDGVRVCNVRRYGDAAVAELAIALMMELARHVGELDTQVREGSWHGVFGTELAGKTLGLVGFGGIGQHVARIANGFGMRIQVWNSHVHADALAANPEIALVDGIDDLMATSDIVSLHLPLTDETRGGITFENLNHLRPGSMLINTARAEIIAPGALERRLERGDLLAGLDVFDKEPLPQDSPLRSVPGVVLTPHVAWRADGAYASLTRQVMEAIVSFYEGGDFNVVV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW16</accession>
    <name>RL2_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplB</name>
        <name type="ordered locus">BLA_0365</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268578.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DW16"/>
    <dbReference type="SMR" id="B8DW16"/>
    <dbReference type="STRING" id="442563.BLA_0365"/>
    <dbReference type="EnsemblBacteria" id="ACL28667">
        <property type="protein sequence ID" value="ACL28667"/>
        <property type="gene ID" value="BLA_0365"/>
    </dbReference>
    <dbReference type="GeneID" id="66532748"/>
    <dbReference type="KEGG" id="bla:BLA_0365"/>
    <dbReference type="HOGENOM" id="CLU_036235_2_1_11"/>
    <dbReference type="OMA" id="SCIELRP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000165723" description="50S ribosomal protein L2">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="276" mass="30439" checksum="A568AB48ED35E8CA" modified="2009-03-03" version="1">MAIRVYKPTTPGRRNASVSDFSDLTRSTPEKSLIRKNSKTGGRNNYGRMTSRHRGGGHKRQYRLIDFRRWDKDGVPATVAQIEYDPNRSARIALLHYADGEKRYIIAPEGIKQGDRIETGANADIKPGNNLPLRNIPTGTVVHAIELRPLGGAKIARSAGAAVQLVAKDGAYAQLRMPSGEIRNVDARCRATVGEVGNSDHANIQLGKAGRARWMGKRPITRGESMNPVDHPHGGRTRGGKPPVSPWGKGEVRTRRPKKASNKMIVRRRPNGKNRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW28</accession>
    <name>RL6_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplF</name>
        <name type="ordered locus">BLA_0377</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268595.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DW28"/>
    <dbReference type="SMR" id="B8DW28"/>
    <dbReference type="STRING" id="442563.BLA_0377"/>
    <dbReference type="EnsemblBacteria" id="ACL28679">
        <property type="protein sequence ID" value="ACL28679"/>
        <property type="gene ID" value="BLA_0377"/>
    </dbReference>
    <dbReference type="GeneID" id="66532760"/>
    <dbReference type="KEGG" id="bla:BLA_0377"/>
    <dbReference type="HOGENOM" id="CLU_065464_1_2_11"/>
    <dbReference type="OMA" id="KPDPYKG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_L6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000166790" description="50S ribosomal protein L6">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <sequence length="179" mass="18975" checksum="0E2829F79504728A" modified="2009-03-03" version="1">MASHIGKLPIEIPAGVEVTINGQEFAAKGAKGSDSYTIPEGVTAKVEGNEIIVTANDDLRPTRAKHGLARSIVASMVKGVHDGYSKSLDIVGTGYRAQMKGKGIEFSLGYSHTITVNPPEGITLELPNPNQVIVKGTDKQAVGQVAANIRKLRAPEPYKGKGIKYSDEVIRRKAGKAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW63</accession>
    <name>B8DW63_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">O-acetylhomoserine (Thiol)-lyase</fullName>
            <ecNumber evidence="3">4.4.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.11" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0412"/>
    <dbReference type="EnsemblBacteria" id="ACL28714">
        <property type="protein sequence ID" value="ACL28714"/>
        <property type="gene ID" value="BLA_0412"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0412"/>
    <dbReference type="HOGENOM" id="CLU_018986_5_3_11"/>
    <dbReference type="OMA" id="ANDHILC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018826">
        <property type="term" value="F:methionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="243" mass="25229" checksum="77E8ECC813DF9A14" modified="2009-03-03" version="1">MTAPLTDWLTMAHFSTLAIHAGYDSADCTNGDAAVPPIYLSAAFDMQSAAHGDALSAGAAEGFSYSRMANPTLDVLERRIAALEGGRSAVAFASGMTAVSAALLCAAEGGGRIIAARNLYGASVDAMDSLFPEFGIETDFVDDINDLALVESLIGPDTRAIFAGSVANPSTEVADVAALASVAHRHGIPLIIDNTVPTPYLFRPIELGADVVVHSTTNSKWMAAVSRSRGFSMAPTCSPMCRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW67</accession>
    <name>B8DW67_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28718">
        <property type="protein sequence ID" value="ACL28718"/>
        <property type="gene ID" value="BLA_0416"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0416"/>
    <dbReference type="HOGENOM" id="CLU_3340705_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="37" mass="3958" checksum="BB766A8498ADF857" modified="2009-03-03" version="1">MFDGRISRFGAFWPFGAPATDMNQVVQIVGKASVANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW72</accession>
    <name>B8DW72_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_0421</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268691.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0421"/>
    <dbReference type="EnsemblBacteria" id="ACL28723">
        <property type="protein sequence ID" value="ACL28723"/>
        <property type="gene ID" value="BLA_0421"/>
    </dbReference>
    <dbReference type="GeneID" id="66532805"/>
    <dbReference type="KEGG" id="bla:BLA_0421"/>
    <dbReference type="HOGENOM" id="CLU_007946_6_0_11"/>
    <dbReference type="OMA" id="SRWVWTA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL28723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="509" mass="53952" checksum="C666C4CA20C741A7" modified="2009-03-03" version="1">MTAATKSQGTPAPNNTGAGGPVTVKRTLSVFDLVVFGMIFMVPIAPFSILASVANTSHGMPALAYVIAMVAMLFTAFSFDLMVPRYPSSGSIFVYASDEINGPVGFVVGWLMLLQYLITPAVMLIMAGLAIHEYVPAVPVWAWCLIFLAIITVIAMRGAGATVMVDKLALVAELIVLLLFFIFGVIYVAKNPSVAHFSFEGFYNPGHFEMGAVMSAVSLCALSFVGFGSVVTLDDQSLDPKHGPSRAMIVIVLILGALYMAMSLLTMCMDPSGKLMAANPNNGFYLVAGLAGKWLGVLCAVANALALGIFTSLSGMTAGASLLRVMAKDDALPSVFAKISPKTRVATVATGFVAVLTLALIFIVLPIGMTTGAKISNYGALSTYFMLNIAVIWGLGIKAKILEHGKFWRTIIFPLIGAIVTGVIFCSLGGEVLIVGTVWLVLGIIFYYVWTKALHHTPDLLSDSRAKGETKAQRIARNAQADAHAKQVAQNVLDQQTAADSMSNESSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW80</accession>
    <name>B8DW80_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0430"/>
    <dbReference type="EnsemblBacteria" id="ACL28731">
        <property type="protein sequence ID" value="ACL28731"/>
        <property type="gene ID" value="BLA_0430"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0430"/>
    <dbReference type="HOGENOM" id="CLU_016043_11_4_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50911">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C51" evidence="2">
        <location>
            <begin position="5"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="136" mass="14737" checksum="4503FCD34E461053" modified="2009-03-03" version="1">MDEHQGQLPQGFDANHETGDRGNAYPYGQCTWWAYERRAQLGLNTGSHFGNAGSWAVSAGSMGYWVDNTPRNTGDALVFSPGQEGASGVYGHVAVVEKVNPDGSIEISESNVQGVGVISHRTFTSAQARNFQYIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW85</accession>
    <name>B8DW85_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrofolate reductase</fullName>
            <ecNumber evidence="3">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dfrA</name>
        <name evidence="9" type="ordered locus">BLA_0435</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268723.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0435"/>
    <dbReference type="EnsemblBacteria" id="ACL28736">
        <property type="protein sequence ID" value="ACL28736"/>
        <property type="gene ID" value="BLA_0435"/>
    </dbReference>
    <dbReference type="GeneID" id="66532820"/>
    <dbReference type="KEGG" id="bla:BLA_0435"/>
    <dbReference type="HOGENOM" id="CLU_043966_5_0_11"/>
    <dbReference type="OMA" id="RDNQLPW"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017925">
        <property type="entry name" value="DHFR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="PTHR48069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00075">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="8">
        <location>
            <begin position="36"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL28736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="227" mass="25684" checksum="6836EEE6BF889F87" modified="2009-03-03" version="1">MESGSSRSGYHEPVPGSAGPEVFEDDWGDDFPKTFSVNLIWAQANDKEGRSGAIGYEGEMPWHLPEDLKRFKELTVSHPVIMGRKTWEALNEKFRPLPNRDNIVLSRDRDFRAPGATVVDNLEEALDMARQEAIPDDGLDRSEIWVIGGSQLFNQMLPMASKIYMTQVDAKVNADAYAPDLTEALNNGSWKLMENSGWLTPKKPEGIDRYRYLTFERNTGDEQAEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW97</accession>
    <name>B8DW97_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0447"/>
    <dbReference type="EnsemblBacteria" id="ACL28748">
        <property type="protein sequence ID" value="ACL28748"/>
        <property type="gene ID" value="BLA_0447"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0447"/>
    <dbReference type="HOGENOM" id="CLU_086277_0_0_11"/>
    <dbReference type="OMA" id="WLDVVEH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025449">
        <property type="entry name" value="DUF4194"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13835">
        <property type="entry name" value="DUF4194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="247" mass="26691" checksum="191657C2F698184B" modified="2009-03-03" version="1">MLSAEYEEGVADEAGMADLANVHALFDGDIGDMPAPAREAAIALKRNRSISGDMYHQALDYMEHVRRSLNNDMLVPVIDTYYEVMYAEPITADEYGIRSLKTRASLSAREAVMLAALRRKVLDYENVGAAAADWLISKEEIVNTMSTGAGPLAGRNSEEAVQAQVDRLIGSAKNNGFLAPVEDDEGMYVITKLVPVVLNPERIAAWLGADDASTAQPEPDGTGDDSDGSGHTGQDEHPEDDDMEALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW98</accession>
    <name>B8DW98_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268761.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0448"/>
    <dbReference type="EnsemblBacteria" id="ACL28749">
        <property type="protein sequence ID" value="ACL28749"/>
        <property type="gene ID" value="BLA_0448"/>
    </dbReference>
    <dbReference type="GeneID" id="66532833"/>
    <dbReference type="KEGG" id="bla:BLA_0448"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.478"/>
    <dbReference type="HOGENOM" id="CLU_274258_0_0_11"/>
    <dbReference type="OMA" id="ETQTPFY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1143"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="334"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="640"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="1165" mass="130664" checksum="19D5B499AC0AB35F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWD0</accession>
    <name>B8DWD0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Erythrocyte binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28781">
        <property type="protein sequence ID" value="ACL28781"/>
        <property type="gene ID" value="BLA_0482"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0482"/>
    <dbReference type="HOGENOM" id="CLU_920300_0_0_11"/>
    <dbReference type="OMA" id="WYETHEK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="296" mass="32766" checksum="35CAB6A995736698" modified="2009-03-03" version="1">MYAGNEAGSQTELINPNEIAAMGRRPPTSHRRQPDDDDRGFYRRLAVTCVSILAVLAVLIAVIFGIGRHRQSIIAAKRTECERSLVGLDDKVVAYQDLVGGDGELASKIADVDVKDMTVVKQLDIEMASESPATVNCDVSSVEEFENRIAQAKASSQWYDEHTASLRSAIQAVNESRHAKQAEDAHASLEEVLRNADNILTSAQGHVTDEAVWDDLSKLIGEARNRSGETDMGRIGTLMDDLNARMDAVERSNRENLRQEEQARAEAERKAQEAEQKRKEAEAKAKAEEEKNKDKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWD9</accession>
    <name>B8DWD9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28790">
        <property type="protein sequence ID" value="ACL28790"/>
        <property type="gene ID" value="BLA_0491"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0491"/>
    <dbReference type="HOGENOM" id="CLU_2714225_0_0_11"/>
    <dbReference type="OMA" id="ERKAEHQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="84" mass="9545" checksum="93FF6234DE811C56" modified="2009-03-03" version="1">MGYRLLTRKVVVMADEKKPHETLKERFDDFKADVDVHKAEHQEKDAIKDVERAAKHDAKSDVDLDKAAANVDKAIEREAEAKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWE0</accession>
    <name>B8DWE0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DppA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dppA</name>
        <name evidence="3" type="ordered locus">BLA_0492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619741.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0492"/>
    <dbReference type="EnsemblBacteria" id="ACL28791">
        <property type="protein sequence ID" value="ACL28791"/>
        <property type="gene ID" value="BLA_0492"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0492"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.522"/>
    <dbReference type="HOGENOM" id="CLU_017028_0_3_11"/>
    <dbReference type="OMA" id="YDFFTWE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870936" evidence="1">
        <location>
            <begin position="36"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="99"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="566" mass="60758" checksum="319787F21C7C9EE7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWG8</accession>
    <name>B8DWG8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Anaerobic ribonucleoside-triphosphate reductase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nrdG</name>
        <name evidence="8" type="ordered locus">BLA_0520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0520"/>
    <dbReference type="EnsemblBacteria" id="ACL28819">
        <property type="protein sequence ID" value="ACL28819"/>
        <property type="gene ID" value="BLA_0520"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0520"/>
    <dbReference type="HOGENOM" id="CLU_089926_2_0_11"/>
    <dbReference type="OMA" id="NQVIHYL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043365">
        <property type="term" value="F:[formate-C-acetyltransferase]-activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012837">
        <property type="entry name" value="NrdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352:SF2">
        <property type="entry name" value="PTHR30352:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00299">
        <property type="entry name" value="anaerobic_ribonucleoside-triph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02491">
        <property type="entry name" value="NrdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="249" mass="28312" checksum="C28F4DE31D579033" modified="2009-03-03" version="1">MAEAANMNDSANGTWRSTGKPRLHDFAAGETGRGPAIPTPMSNNPKPGQWTNRMSHNMIADYKRFLMTDGEGIRCSLYVSGCPFHCVECYNSSIWDFQAGHEYNDKLEAQIMDDLAQSFVQGITFLGGEPLLNTGVLLPLARKIRERFGHTKDIWCWTGYTWEELMRDGETQDKLDLLHEIDILVDGRYIKTLHDSLLQFRGSRNQRILDVQESFRQGKPVVWAKLHDQERFIPEIYGKERAAGEGDAS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWI2</accession>
    <name>DAPA_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="1">HTPA synthase</shortName>
            <ecNumber evidence="1">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dapA</name>
        <name type="ordered locus">BLA_0534</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269222.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DWI2"/>
    <dbReference type="SMR" id="B8DWI2"/>
    <dbReference type="STRING" id="442563.BLA_0534"/>
    <dbReference type="EnsemblBacteria" id="ACL28833">
        <property type="protein sequence ID" value="ACL28833"/>
        <property type="gene ID" value="BLA_0534"/>
    </dbReference>
    <dbReference type="GeneID" id="66533664"/>
    <dbReference type="KEGG" id="bla:BLA_0534"/>
    <dbReference type="HOGENOM" id="CLU_049343_7_1_11"/>
    <dbReference type="OMA" id="GMDACVP"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0457">Lysine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0704">Schiff base</keyword>
    <feature type="chain" id="PRO_1000134858" description="4-hydroxy-tetrahydrodipicolinate synthase">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="1">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="303" mass="32204" checksum="1BEC4403872EAA5E" modified="2009-03-03" version="1">MSDGIMHLLDPAPFGRVLPAMITPMKPNGDVDFDMAQTVAKQLVADGADGLVVNGTTGESPTTHMDEKVELVKAVKEVVDVPVISGAGSNDTAHTVRMVEQTQEAGADAVLVVCPYYSRPSQQGIFCHYQAVNESADKPIIVYDVPGRTGVRIALDTYVHLAELDHVKAVKDATGDIAGAVRKRMETGLTWYSGDDALYLPFLSIGAVGIISVVAHAAAKPMRELAEAFDRGDIAKAQGLANRIAPVIEAMNGTGFQAVMAKAALKVRGIMECTTMRLPNIGPNDEQIEVVRDGLRASGLIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWJ3</accession>
    <name>B8DWJ3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218264.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0545"/>
    <dbReference type="EnsemblBacteria" id="ACL28844">
        <property type="protein sequence ID" value="ACL28844"/>
        <property type="gene ID" value="BLA_0545"/>
    </dbReference>
    <dbReference type="GeneID" id="66533675"/>
    <dbReference type="KEGG" id="bla:BLA_0545"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.574"/>
    <dbReference type="HOGENOM" id="CLU_1329795_0_0_11"/>
    <dbReference type="OMA" id="IAQYAPE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="215" mass="23620" checksum="5883AE969A9C2AD0" modified="2009-03-03" version="1">MVDYQTAVAAVQDPQADPILLAKIAYENPEFGANVAVHPRAYPGLKRWLAEFGDKRARMTLAQMGVIATADPVEDRFDESETPSGQRNPEPARAVKLAVEQLVRNSGAQQPVQARPTRFTQPAQSTQAAQHTLATQPDRATASNPNAQYSANGEFTPQLAMTTSDPAVMHDIAQYAPDLHVYLVQNPYIYPELLNWLASLNETEVNEAIAARRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWK5</accession>
    <name>B8DWK5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable DeoR-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_0557</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0557"/>
    <dbReference type="EnsemblBacteria" id="ACL28856">
        <property type="protein sequence ID" value="ACL28856"/>
        <property type="gene ID" value="BLA_0557"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0557"/>
    <dbReference type="HOGENOM" id="CLU_060699_3_0_11"/>
    <dbReference type="OMA" id="STHEPGF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="273" mass="29328" checksum="81B7BBE834AE3565" modified="2009-03-03" version="1">MCDNVRMISSQRQHLILGRLRTRGAVRITALSKEFGVSAMTIRRDIAELADKGLLRRVHGGAVSTSTLLSEPLFSVKSQMDIGLKDAIAGEAIKFVSPGDVIAIGGGTTAYVFAQHLLESPNANGITILTNSIPVAELVQALESKDVEVIVTGGVITRSNSLVGPIADKVIASLRVNTVFLGTHSVSMPRGFLMPNSLEAATDMAMMDIADRTIILTDHTKWSSTSLSLFAKFDQVDTVITDDGLDPDSVAKTRDLVKELVLAHQIETEEESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWN4</accession>
    <name>B8DWN4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oligosaccharide repeat unit polymerase Wzy</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218320.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28885">
        <property type="protein sequence ID" value="ACL28885"/>
        <property type="gene ID" value="BLA_0588"/>
    </dbReference>
    <dbReference type="GeneID" id="66533716"/>
    <dbReference type="KEGG" id="bla:BLA_0588"/>
    <dbReference type="HOGENOM" id="CLU_610682_0_0_11"/>
    <dbReference type="OMA" id="NIFINIM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="448" mass="49921" checksum="0310C45DFBB03DF1" modified="2009-03-03" version="1">MTDTTETVQRQAEYSPRIREVVNALMDYALVLAIIYNSNSLWALAGDNFSLSCFVLLAVCMAYMLCCWREARHRLHRVGSAMLVLVLATVIGQLVMAVSHGGSGYTNGTWFQYALIVPALMGCMLMRGHEYVRKVLLNRLVVVAAVFAAISVVLWAASSFLLLPPSHVERLSWVHNVPPIYSYADVYYNVQDAHVLGMTVWRNSSIFNEPPCAVAFYGMVLAIDLYIGKKVHWGADLCIIGALVTSLSTGGALYVLVLLVPLLWKAMLHVQRRGLRYALLSVAALVSIAAVVAGTRIVISKMATSYSGQTHLLDFTEGFRIWWQRPLTGFGFDSDEYIWTHYMSAYRDGMGYTSGLLFLLIHGGLVLALYMIVPFVLLVLGSHDWHMWYFAGFVMIVFITAPVQNCAFLLLVAAYGYASFIWRYSRRMSSLPLVARTPLTHEGSEGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWN6</accession>
    <name>B8DWN6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218322.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0590"/>
    <dbReference type="EnsemblBacteria" id="ACL28887">
        <property type="protein sequence ID" value="ACL28887"/>
        <property type="gene ID" value="BLA_0590"/>
    </dbReference>
    <dbReference type="GeneID" id="66533718"/>
    <dbReference type="KEGG" id="bla:BLA_0590"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.621"/>
    <dbReference type="HOGENOM" id="CLU_065769_1_0_11"/>
    <dbReference type="OMA" id="HYRRFFS"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025536">
        <property type="entry name" value="DUF4422"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14393">
        <property type="entry name" value="DUF4422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF4422" evidence="1">
        <location>
            <begin position="9"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="254" mass="29993" checksum="FECA46694614A40B" modified="2009-03-03" version="1">MSVSSETIMYIVSHKDFDAPQLPGYVPILAGAVKNHASIEVKDNTGDNISAKNPGFCELTAQYWVWKNRDDRDANIGFVHYRRYFYIDHRKAQIVPAEQFSRDLEQYDVVLPEPWVLRKTIGDQFAQFHNLDDLEVVRSIMQEQCPEYVPALDELLKSHSLHAYNMFVMSGERFDAYMTWLFRILDEAERRIDVSKYDAYNQRLFGFLSERLLNVWVNARKLRVKEYPVYMPEQSARKENLRTRVKSLLFEHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWR9</accession>
    <name>B8DWR9_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fkbP</name>
        <name evidence="7" type="ordered locus">BLA_0627</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 4"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619787.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0627"/>
    <dbReference type="EnsemblBacteria" id="ACL28920">
        <property type="protein sequence ID" value="ACL28920"/>
        <property type="gene ID" value="BLA_0627"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0627"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.658"/>
    <dbReference type="HOGENOM" id="CLU_053307_0_0_11"/>
    <dbReference type="OMA" id="AHYTGWT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867575" description="Peptidylprolyl isomerase" evidence="5">
        <location>
            <begin position="31"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="236"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL28920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="322" mass="33835" checksum="3FE4565C8A4B9BDE" modified="2009-03-03" version="1">MTQAKSAGIRKRAVQAVAAMCVAATCFAFAACGNSNASESTGKSSASSSASSGLTKIEGVKDTAKVGEKPVLEFKKPLNVPDNSYAILQEGDGEVIKPGNRVCAQGMAVDGKTGDIKMSTWETNQMDCSLVAPKKGEKTSALLSVIDGLKLNSTVVFGSNDSTADSSNLIVMTLKSQSTDLTKAEGTKVKDIPSDLPKVTNAADGKPSIDMNGYKDSDKLVVQPLIEGDGEKLDSNSYAVVKYTGWLLDGKQFDSSWDRNSTFDVNMQGGVIEGWLEGLKGQKVGSEVLLVVPPSLGYGDQAQGEIPANSTLVFVVDILAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWT9</accession>
    <name>B8DWT9_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Formyl-CoA:oxalate CoA-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">frc</name>
        <name evidence="2" type="ordered locus">BLA_0647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219152.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0647"/>
    <dbReference type="EnsemblBacteria" id="ACL28940">
        <property type="protein sequence ID" value="ACL28940"/>
        <property type="gene ID" value="BLA_0647"/>
    </dbReference>
    <dbReference type="GeneID" id="66533780"/>
    <dbReference type="KEGG" id="bla:BLA_0647"/>
    <dbReference type="HOGENOM" id="CLU_033975_2_1_11"/>
    <dbReference type="OMA" id="KFDIPCA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033608">
        <property type="term" value="F:formyl-CoA transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017659">
        <property type="entry name" value="Formyl_CoA_transfer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03253">
        <property type="entry name" value="oxalate_frc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="443" mass="48905" checksum="BF3CCC91FCA4D189" modified="2009-03-03" version="1">MADKSTAPLAGIKVIDWTQVQSGPSCTQILAWLGAEVIKLEKVHGGDPTRNEMNDVDGSYSLYFLQLNANKKSITLDMKDPEGKKILTDLLKDADVFVENIGPGDVEKLGFGWDEVHKINPKLIMASLKGFNQGSRFEHVKAFEPVAQCAGGAASTTGWWEGDKNIPTQSGAALGDSNTGMHLTIAILTALLQRERTGEGVFVYQSMQNAVLNLCRIKLRDQLILDHLHQLSYYDCYPGYKFGKAIPRAANAEGGLVLGWCYRAKGWETDPNAYVYIVIQQSQKGFENFCNAMGFQDWLTDPKFSTPNARDEHKQEVYKRVEEYTMQYDKYTLTKELGAKGVPVGPVLDWNELENDPDLNEDGTLITIDQGDARGKFKTIGLPFTMSNYAPDYQRAPKLGENNEEILKSLGYTDEQIADLATKGVIGSNDGVKADLTAAPAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWV9</accession>
    <name>B8DWV9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Possible acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.57</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.57" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219122.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0667"/>
    <dbReference type="EnsemblBacteria" id="ACL28960">
        <property type="protein sequence ID" value="ACL28960"/>
        <property type="gene ID" value="BLA_0667"/>
    </dbReference>
    <dbReference type="GeneID" id="66533800"/>
    <dbReference type="KEGG" id="bla:BLA_0667"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.695"/>
    <dbReference type="HOGENOM" id="CLU_046132_0_0_11"/>
    <dbReference type="OMA" id="AWWRIIG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004145">
        <property type="term" value="F:diamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="34"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="347" mass="38773" checksum="346512C43416B139" modified="2009-03-03" version="1">MTAVVDGDSGEGTARSRELPSQITIPCIQGEMVYLRPASVGDLASMDALDAYVNASGVTGKDRVAERAAVQAWVRRSQAWVDGIESRKSGIGDPESRRTIAWAMLTVPEEHEDETVNEHTATEFIGMIFLIDIDGWARSARIQVILGKEYRGRGYSRDAMPRVMTYGFADEPEGLGLHRIWVAVPEKNTRSYSVYQSLGFVPSGTSRDALWDEANNKYQDLNVLDTLVDEYDPVRAMDAFGMHVITTNPGMEKALLLHQHSTAIRKQALSDTIASQPEAHSDEAQDETTMGDKMKSDSARIAQDNIESENTWPYNSTERNKSKKAWWRRLGHDRMSSRNANDSQQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSI5</accession>
    <name>B8DSI5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter, integral membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0671"/>
    <dbReference type="EnsemblBacteria" id="ACL28964">
        <property type="protein sequence ID" value="ACL28964"/>
        <property type="gene ID" value="BLA_0671"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0671"/>
    <dbReference type="HOGENOM" id="CLU_051674_1_0_11"/>
    <dbReference type="OMA" id="EWHKLWT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="311" mass="32558" checksum="B49DDC11A2CAD054" modified="2009-03-03" version="1">MQSANPTGTPSGTVPGAAHGAAHGASHARRLGFGGALRAEWCKVWSVTSTYVLLVLAIVFFAVNSLMMGWLMRFVESQGDGMPLGNEDLWAAVSSGADNVLLIVGILGVMVLTSEFSSSSIITSLTVNPRRTMFMNAKALVLAVVTFLASFVGMLLAWGCAAIMMGSSVSTGNAEMPAAMPWVTLLGIPLAMALGAVMSMGFGALCRSTAGGVLCVVVLFMIVPSMLQMVQLLGEKFTWVVSLNNCLPANALTYFTGVGANSFSNSASAQLSMGATHPFQPSWGWAGLIYLAWAVVVYAAGVIVMDRRDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSJ1</accession>
    <name>B8DSJ1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative fumarylacetoacetate (FAA) hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">faaH</name>
        <name evidence="3" type="ordered locus">BLA_0677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219108.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0677"/>
    <dbReference type="EnsemblBacteria" id="ACL28970">
        <property type="protein sequence ID" value="ACL28970"/>
        <property type="gene ID" value="BLA_0677"/>
    </dbReference>
    <dbReference type="GeneID" id="66533810"/>
    <dbReference type="KEGG" id="bla:BLA_0677"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.705"/>
    <dbReference type="HOGENOM" id="CLU_028458_4_2_11"/>
    <dbReference type="OMA" id="YALSIDM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018833">
        <property type="entry name" value="DUF2437"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10370">
        <property type="entry name" value="DUF2437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2437" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="64"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="273" mass="29751" checksum="F43A040D683AA407" modified="2009-03-03" version="1">MRLARFSRNDTPQYAFVQKDATDGKDYLVVLDGHPLLQQVTPTGERVALDEDGVRLLAPVIPSKVYGLAKNYEAHAQFMHEHNQSPQAHAPAEMVIFTKPSTSVIGPDDPIVYPTYSHDMNYEPEVAVVMGRIAKNVPVDKAMDYVLGFTCVNDVTLRDLQGSDPMWTRAKGFDTSCPLGPWIVTKDEFDWRDARIGFTLNGEDVPAASGTTANLIHNIAEQIAGISSFSTLLPGDVIMTGTPNASGTLKPGDEAIVRVEGIGELRNVVVQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSL2</accession>
    <name>B8DSL2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-damage-inducible protein J</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RelB/DinJ antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219443.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0698"/>
    <dbReference type="EnsemblBacteria" id="ACL28991">
        <property type="protein sequence ID" value="ACL28991"/>
        <property type="gene ID" value="BLA_0698"/>
    </dbReference>
    <dbReference type="GeneID" id="66533905"/>
    <dbReference type="KEGG" id="bla:BLA_0698"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.728"/>
    <dbReference type="HOGENOM" id="CLU_154558_5_3_11"/>
    <dbReference type="OMA" id="ADAKCMF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015643">
        <property type="term" value="F:toxic substance binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044010">
        <property type="term" value="P:single-species biofilm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026262">
        <property type="entry name" value="DinJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007337">
        <property type="entry name" value="RelB/DinJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38781">
        <property type="entry name" value="PTHR38781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04221">
        <property type="entry name" value="RelB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003108">
        <property type="entry name" value="DinJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02384">
        <property type="entry name" value="RelB_DinJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="89" mass="10090" checksum="C1A05E3C9FA535EE" modified="2009-03-03" version="1">MNMTSVTVRVDEDTKKQASDIAEDFGFDLSSVTRAFYRQIVRERRIPLNLSYSNVPEETLEALAEARRMAKEGAPRFQDADAMFDSLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSL6</accession>
    <name>B8DSL6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219371.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28995">
        <property type="protein sequence ID" value="ACL28995"/>
        <property type="gene ID" value="BLA_0702"/>
    </dbReference>
    <dbReference type="GeneID" id="66533898"/>
    <dbReference type="KEGG" id="bla:BLA_0702"/>
    <dbReference type="HOGENOM" id="CLU_160596_0_0_11"/>
    <dbReference type="OMA" id="IMYHDKA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="83" mass="10097" checksum="65F8B4CE119B793E" modified="2009-03-03" version="1">MHYFTPKRCETTTKIMYHDRQTAWQAAEQSRIERGVELWVYQCQYCGQWHLTHRDPALAQAVGHFKRSQKPYSRKKGFKPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSM0</accession>
    <name>B8DSM0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable alpha-1,4-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">aglA</name>
        <name evidence="4" type="ordered locus">BLA_0706</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="4"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219382.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0706"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28999">
        <property type="protein sequence ID" value="ACL28999"/>
        <property type="gene ID" value="BLA_0706"/>
    </dbReference>
    <dbReference type="GeneID" id="66533894"/>
    <dbReference type="KEGG" id="bla:BLA_0706"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.737"/>
    <dbReference type="HOGENOM" id="CLU_006462_0_1_11"/>
    <dbReference type="OMA" id="MNNHDVP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032450">
        <property type="term" value="F:maltose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="3">
        <location>
            <begin position="18"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="591" mass="66632" checksum="F74334F96BAC5DF9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSM1</accession>
    <name>B8DSM1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible solute binding protein of ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0707"/>
    <dbReference type="EnsemblBacteria" id="ACL29000">
        <property type="protein sequence ID" value="ACL29000"/>
        <property type="gene ID" value="BLA_0707"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0707"/>
    <dbReference type="HOGENOM" id="CLU_031285_12_3_11"/>
    <dbReference type="OMA" id="FQFKVEI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867570" evidence="1">
        <location>
            <begin position="37"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="449" mass="49321" checksum="FCB9713486765C6B" modified="2009-03-03" version="1">MRKGSKMNRTVKATVGLVAIAAMSLTGLAACGGSSADDGKGKVYFLNFKPEAADQWVALAKKYTDKTGVQVKVQTAASGTYEQTLKSELAKSDAPTIFQVNGPVGYQNWKGYTADLKDTGIYNELNNKDIALKDGDKVVGIPYVMETYGIIYNKDLLKKYTELPGAKIKDVKEIDSFDKLKEVADDMQAKKDQLGIKGAFTSAGFDSSSDWRFKTHLANIPLSYEFKEDGVTTQPETIKGTYLPNFKNIFDLYLKDSTTAPSQLSSKTGDDANSEFALGEAAFYQNGTWAWTDLQKAGMKPDQVGMLPIYIGAKGEENQGLATGSENYLCINAKASEADQKASKDFLNWVVTSDEGIKALSEDMGFTTPFKTFDKVKSDNPLVEEAVEDSNSGKEQVAWNFTMMPSEEWKNQLGQAMLAYAQGNGSWDDVQKAFVDNWKTEYDNAHANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSN2</accession>
    <name>B8DSN2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Possible exodeoxyribonuclease</fullName>
            <ecNumber evidence="3">3.1.11.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269170.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0718"/>
    <dbReference type="EnsemblBacteria" id="ACL29011">
        <property type="protein sequence ID" value="ACL29011"/>
        <property type="gene ID" value="BLA_0718"/>
    </dbReference>
    <dbReference type="GeneID" id="66533479"/>
    <dbReference type="KEGG" id="bla:BLA_0718"/>
    <dbReference type="HOGENOM" id="CLU_027539_3_0_11"/>
    <dbReference type="OMA" id="WWSYRGR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037493">
        <property type="entry name" value="ExoIII-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43250">
        <property type="entry name" value="PTHR43250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="286" mass="32253" checksum="1C1A4B8A68AC3C7C" modified="2009-03-03" version="1">MALTITTSNLNGIRAAKRKGFDHWAKAHTPNVWCMQETRAPQEIIADIYGELAADYVHAGKIASPEELHTLVDVCRIKGRAGVGMISDMPVLETRVGLPGLEEDVDSGRWIEADVRTEQGYVITVVCVYVHAGGLVDDPKEAQKYRFLDTMTERMQQLQDEAASGGRQAVVCGDFNIAHNPIDLKNPKSNENNNGYFPRERAYMDKWIDQMDYVDVMRDLAGDIQGPYTWWSQRGRAFDNDSGWRLDYQFATPELAQQARGFVVDRASSYDSRWSDHAPLTISYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSP4</accession>
    <name>B8DSP4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase, class IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0730"/>
    <dbReference type="EnsemblBacteria" id="ACL29023">
        <property type="protein sequence ID" value="ACL29023"/>
        <property type="gene ID" value="BLA_0730"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0730"/>
    <dbReference type="HOGENOM" id="CLU_105324_0_0_11"/>
    <dbReference type="OMA" id="GYFWLYG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="186" mass="20385" checksum="1A79BF186BAC329A" modified="2009-03-03" version="1">MHICACPEIPRDAYDGAMSQNTNVTEYVTAGDDAQESALPWSYRQRPWLRYLIDVVSGAALGIVGTFAHRMGAAQNIPYGLVLALLLVALGAWSARSRDGVAGFALYFIASTTVLYFLALRSGDVLIAAGFASDSLPFWSQHAGYSWLFGVVVVQLLLLVFPRRFFSMPTRRVGRRKSENDSGTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSS2</accession>
    <name>B8DSS2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phage-related integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_0758</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218675.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0758"/>
    <dbReference type="EnsemblBacteria" id="ACL29051">
        <property type="protein sequence ID" value="ACL29051"/>
        <property type="gene ID" value="BLA_0758"/>
    </dbReference>
    <dbReference type="GeneID" id="66533518"/>
    <dbReference type="KEGG" id="bla:BLA_0758"/>
    <dbReference type="HOGENOM" id="CLU_027562_17_5_11"/>
    <dbReference type="OMA" id="YTHITQS"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="61"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="166"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="366" mass="41069" checksum="992E370D189B2ED0" modified="2009-03-03" version="1">MSYTVGKYETKKCVKWEVRYRTPGGRTTRKRGFLRKMDAEAWAAENVEIAKAKGTFITQSAGNTPVAELWQSWIETKRTRCKPSYMESLGGAWNKHVGPQWGARKVGSIRHDEVQEWVNKLAGEYSASVVIRARDMLKGLLKAAVKNRLIASNPADDITVPRKKRKDHVYLTAEQLMALADEAGWRRPAVLALGTTGMRWGELVGLRVRDLDAKGHRLRIERNAVEVKGEVVIGTPKTYEKRTITYPAILEPMLVEMAQGRDGDEPLFVDQQGKMLRRTHGPNSPSSWFYWAKKRALGDVLARKMTVHDLRHTAASLLVSAGANVKVVQRQLGHESAAMTLDTYADLFDADLDVVRVEMDSIFPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSV0</accession>
    <name>B8DSV0_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.1.399</ecNumber>
            <ecNumber evidence="7">1.1.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-oxoglutarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">serA</name>
        <name evidence="14" type="ordered locus">BLA_0787</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.399" evidence="6"/>
    <dbReference type="EC" id="1.1.1.95" evidence="7"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0787"/>
    <dbReference type="EnsemblBacteria" id="ACL29079">
        <property type="protein sequence ID" value="ACL29079"/>
        <property type="gene ID" value="BLA_0787"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0787"/>
    <dbReference type="HOGENOM" id="CLU_019796_9_2_11"/>
    <dbReference type="OMA" id="YGNIGTQ"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="13">
        <location>
            <begin position="333"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00021582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACL29079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="403" mass="43495" checksum="A52540AE7D543BCA" modified="2009-03-03" version="1">MGSMPKALLLENIHPLAAESLRAHGFEVETRKGALSERELIDALEGVDVLGVRSKTTVTRAVIDARPTLTAIGCFCIGTNQVDLNHAAKNGIAVFNAPYSNTRSVVELVICDIICLMRRIPAHTHHMKHGVWDKSASGSHEVRGKTLGIIGYGNIGSQLSVLAEALGMSVIFYDLEEKLALGNARRCETLHELLNEADAVTIHVDGRKSNTGFFGEKQFSQMKQNAIFINASRGFVVDLDALKEHLDSGHLSGAAIDVFQNEPKKTGDPFSTPLADEDNMILTPHIGGSTLEAQENIAQFVSQRLEDYWFKASTMLSVNLPQITTGPCKGAARIAHLHANLPGVLAKVNQVLGEQDINISAQALGTEGEIGYVVTDVTKCPDEVTIDALDAITGTIRTRVIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSW0</accession>
    <name>B8DSW0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29089">
        <property type="protein sequence ID" value="ACL29089"/>
        <property type="gene ID" value="BLA_0797"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0797"/>
    <dbReference type="HOGENOM" id="CLU_032121_0_0_11"/>
    <dbReference type="OMA" id="QFRDMKD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018721">
        <property type="entry name" value="DUF2252"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39441">
        <property type="entry name" value="PTHR39441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10009">
        <property type="entry name" value="DUF2252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="481" mass="54506" checksum="98F5C23EFA06DC46" modified="2009-03-03" version="1">MSDGNLVESSEAHPMFDMSAWTEFKNPEDRTNAGLKLRERFPLSSHAVWRVQTKRRDVIGLLEEQNKMRVPDLVPLRFKRMSANAFTFYRGGAAIMANDLARTPTTCIPVQCIGDAHIGNFGIFYSPSKRLVFDINDFDETATGPWEWDIKRLAVSVEIAGRNIGLKEKERHDAVYRCVKQYRETLREFSQMGFLNTWYTHFDVEDSLAHLEKAMKAKPSKTLHGAIAKARSKDSKKAANKLTYLDGNRLRFKTEPPELVQINDIRGYEDIDALRGRLRQLFDTYRDSLYEDRRHVLEQYHYQDTARKVVGVGSVGTRCWISAFIGRDIDDPLILQMKEAVASVLAKYVGHSPYSTHGERVIQGQKLVQSTADILLGWSRFVANDGLPRDYYVRQLWNGKGSIDLDTLHADSLSNLGSLCAWCLAHAHARSGDSVAISGYLGDSDEFETAMMSFCDSYADQNEDDFELFTQLIASGELPCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSY6</accession>
    <name>B8DSY6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29115">
        <property type="protein sequence ID" value="ACL29115"/>
        <property type="gene ID" value="BLA_0823"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0823"/>
    <dbReference type="HOGENOM" id="CLU_187423_0_0_11"/>
    <dbReference type="OMA" id="AHTVGNE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="57" mass="6689" checksum="57C44AC6D845E70F" modified="2009-03-03" version="1">MTGGDSVEQIVDAERERERLLLRSGVDRIVRFRVRETYDCARFIRKLLEAGVPLRKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSY8</accession>
    <name>RECO_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA repair protein RecO</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Recombination protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">recO</name>
        <name type="ordered locus">BLA_0825</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA repair and RecF pathway recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecO family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218580.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DSY8"/>
    <dbReference type="SMR" id="B8DSY8"/>
    <dbReference type="STRING" id="442563.BLA_0825"/>
    <dbReference type="EnsemblBacteria" id="ACL29117">
        <property type="protein sequence ID" value="ACL29117"/>
        <property type="gene ID" value="BLA_0825"/>
    </dbReference>
    <dbReference type="GeneID" id="66533586"/>
    <dbReference type="KEGG" id="bla:BLA_0825"/>
    <dbReference type="HOGENOM" id="CLU_066632_1_1_11"/>
    <dbReference type="OMA" id="LCTQSET"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00201">
        <property type="entry name" value="RecO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022572">
        <property type="entry name" value="DNA_rep/recomb_RecO_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003717">
        <property type="entry name" value="RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042242">
        <property type="entry name" value="RecO_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33991">
        <property type="entry name" value="PTHR33991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02565">
        <property type="entry name" value="RecO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11967">
        <property type="entry name" value="RecO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00613">
        <property type="entry name" value="reco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000193362" description="DNA repair protein RecO">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00201"/>
        </source>
    </evidence>
    <sequence length="239" mass="26414" checksum="F0B0D52A233DB4BE" modified="2009-03-03" version="1">MALYRDEAVVLRTAKLGEADRIITLLTRDHGKVRAVAKGVRRTKSRFGARLEPFMRVDLLLGEGRTFDSVRQAESISAYAGGITGDYATYTAASAMCETAADLLPAEHEPAAAQYRLLIAALGALSRHLHDPQAIALSYILRAMSLAGWTIRLDSCVVCGSQDVEFFSASAGGAMCPNDHTPDAVRVPVHVFDQLRALEQGDWPQLDMLQTPDPRCENIVREWAQYYLERPIRSLRLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSZ6</accession>
    <name>B8DSZ6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218568.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0833"/>
    <dbReference type="EnsemblBacteria" id="ACL29125">
        <property type="protein sequence ID" value="ACL29125"/>
        <property type="gene ID" value="BLA_0833"/>
    </dbReference>
    <dbReference type="GeneID" id="66533595"/>
    <dbReference type="KEGG" id="bla:BLA_0833"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.867"/>
    <dbReference type="HOGENOM" id="CLU_031872_0_0_11"/>
    <dbReference type="OMA" id="LFAHVPW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018766">
        <property type="entry name" value="Zinicin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042271">
        <property type="entry name" value="Zinicin_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39420">
        <property type="entry name" value="PTHR39420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10103">
        <property type="entry name" value="Zincin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03624">
        <property type="entry name" value="TIGR03624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="552" mass="59522" checksum="D627DC7EB62AC642" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT21</accession>
    <name>B8DT21_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29150">
        <property type="protein sequence ID" value="ACL29150"/>
        <property type="gene ID" value="BLA_0858"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0858"/>
    <dbReference type="HOGENOM" id="CLU_1425481_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="190" mass="21586" checksum="281C2D57B064FC8C" modified="2009-03-03" version="1">MSMKSVARHDGPRTRAQRIRCAKHRRARIRAAYRRHLTSMAAGNTYALHAASSGDPLAMPAVANHVTARNGDHDNVKPSAARKAAHPRAGVQNAAPQPTGEKNSRRVNPVTRQWRRFKETKFYEIWNKRPKFSYGAYTVVFIAMVILATMFLWWSTNTKLKYDPASELNFLQQVTGDAYHYRLPPRAISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT42</accession>
    <name>B8DT42_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable potassium transport system protein kup</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">kup</name>
        <name evidence="13" type="ordered locus">BLA_0879</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Transport of potassium into the cell.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the HAK/KUP transporter (TC 2.A.72) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219239.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0879"/>
    <dbReference type="EnsemblBacteria" id="ACL29171">
        <property type="protein sequence ID" value="ACL29171"/>
        <property type="gene ID" value="BLA_0879"/>
    </dbReference>
    <dbReference type="GeneID" id="66533858"/>
    <dbReference type="KEGG" id="bla:BLA_0879"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.919"/>
    <dbReference type="HOGENOM" id="CLU_008142_4_1_11"/>
    <dbReference type="OMA" id="TILLYEW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01522">
        <property type="entry name" value="Kup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023051">
        <property type="entry name" value="K+_uptake_low_affin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="PTHR30540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="365"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACL29171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="730" mass="81247" checksum="F3F5AFE9FA14F28E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT51</accession>
    <name>B8DT51_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal RNA small subunit methyltransferase I</fullName>
            <ecNumber evidence="7">2.1.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">16S rRNA 2'-O-ribose C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">rRNA (cytidine-2'-O-)-methyltransferase RsmI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rsmI</name>
        <name evidence="10" type="ordered locus">BLA_0888</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42924"/>
            <dbReference type="Rhea" id="RHEA-COMP:10285"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.198"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the methyltransferase superfamily. RsmI family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.198" evidence="7"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219288.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0888"/>
    <dbReference type="EnsemblBacteria" id="ACL29180">
        <property type="protein sequence ID" value="ACL29180"/>
        <property type="gene ID" value="BLA_0888"/>
    </dbReference>
    <dbReference type="GeneID" id="66533867"/>
    <dbReference type="KEGG" id="bla:BLA_0888"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.930"/>
    <dbReference type="HOGENOM" id="CLU_044779_0_1_11"/>
    <dbReference type="OMA" id="RTMVFFE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070677">
        <property type="term" value="F:rRNA (cytosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000453">
        <property type="term" value="P:enzyme-directed rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11648">
        <property type="entry name" value="RsmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01877">
        <property type="entry name" value="16SrRNA_methyltr_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018063">
        <property type="entry name" value="SAM_MeTrfase_RsmI_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005917">
        <property type="entry name" value="MTase_YraL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00096">
        <property type="entry name" value="TIGR00096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01296">
        <property type="entry name" value="RSMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="9">
        <location>
            <begin position="30"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL29180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="315" mass="34236" checksum="24F04689AA92C1C7" modified="2009-03-03" version="1">MNEQSEHTGIAEDPADETRTLHVDVPRGTVVLAATPIGNTADASARLVALLERADIVAAEDTRRLYALANRLSVHVGGRVVANHDHNERGKADALLDHVANGETVLVVSDAGMPTINDPGLAIVRRAIERGLPVTCAPGPSAVLDALALSGLPTDRFCYEGFLPRKHSERMQALRALKGERRTIVFYETLHRIAESMADLEEVFGPDRRMALCRELTKDYEQIRRGTIHEINESVANDPPRGEMVLVIAGASEDEADPAQSLSVEELAELAMQYAQAHGMRIKDAIAEVIGKHPNADGTLANRKQVYNAVLALRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT75</accession>
    <name>B8DT75_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_0912</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219250.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0912"/>
    <dbReference type="EnsemblBacteria" id="ACL29204">
        <property type="protein sequence ID" value="ACL29204"/>
        <property type="gene ID" value="BLA_0912"/>
    </dbReference>
    <dbReference type="GeneID" id="66533892"/>
    <dbReference type="KEGG" id="bla:BLA_0912"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.955"/>
    <dbReference type="HOGENOM" id="CLU_037628_6_4_11"/>
    <dbReference type="OMA" id="FAEFMSG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="336" mass="36893" checksum="51FB80752C5C17A5" modified="2009-03-03" version="1">MNASIQDVAKAAHVSISTVSRSFTRPELVSAATREKVLRIAEELNFSTSRSAAALKTGRAMRVALLMSDHIRLWFSASVIEGLNSVLHAEGYDISIFQISSIEERRDFFEMLPVRRNADAVIVASFDADETEIAQLASANVPIIGINSVMPRELGFTAAVNIDDTQGSILAARHLINLGHRDIAYVRTNRDVSLHFSVQQRFDSFMECCAGSGISPTVIVAQEGPDRIRRVLTDLMSLERMPTAIACQEDGIAVPLIFQLERSGYEVPNDISVIGYDNSFYANDIGLTTIAQDPIEMAKMAAEMTVKLIEGEKPEHLFRTIPAELVVRSSTAKHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT78</accession>
    <name>B8DT78_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218356.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0915"/>
    <dbReference type="EnsemblBacteria" id="ACL29207">
        <property type="protein sequence ID" value="ACL29207"/>
        <property type="gene ID" value="BLA_0915"/>
    </dbReference>
    <dbReference type="GeneID" id="66532440"/>
    <dbReference type="KEGG" id="bla:BLA_0915"/>
    <dbReference type="HOGENOM" id="CLU_161187_0_0_11"/>
    <dbReference type="OMA" id="DDYARWA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021426">
        <property type="entry name" value="DUF3073"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11273">
        <property type="entry name" value="DUF3073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="115" mass="12915" checksum="0915FAC3C4B9E8D3" modified="2009-03-03" version="1">MGRGRQKAKQQKIARKLKYMTTDTDYDELAKELGAHEPGTGSFDPFADVENDEFEAQDVDETVDDLDEYAKWAAEAAAKATTGEMPETHAQPKPKPHKPIPMPVPETFKHTDQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT92</accession>
    <name>B8DT92_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="14">DNA translocase FtsK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ftsK</name>
        <name evidence="14" type="ordered locus">BLA_0929</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homohexamer. Forms a ring that surrounds DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FtsK/SpoIIIE/SftA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0929"/>
    <dbReference type="EnsemblBacteria" id="ACL29221">
        <property type="protein sequence ID" value="ACL29221"/>
        <property type="gene ID" value="BLA_0929"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0929"/>
    <dbReference type="HOGENOM" id="CLU_001981_2_0_11"/>
    <dbReference type="OMA" id="IPNVDRE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025199">
        <property type="entry name" value="FtsK_4TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041027">
        <property type="entry name" value="FtsK_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13491">
        <property type="entry name" value="FtsK_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17854">
        <property type="entry name" value="FtsK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
        <property type="entry name" value="FtsK_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00843">
        <property type="entry name" value="Ftsk_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="13">
        <location>
            <begin position="574"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="315"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="397"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="931"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="338"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="407"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="591"/>
            <end position="598"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACL29221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="951" mass="101536" checksum="BEEEFFA5F1BB5130" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTA3</accession>
    <name>B8DTA3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative acyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.51</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.51" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217603.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0940"/>
    <dbReference type="EnsemblBacteria" id="ACL29232">
        <property type="protein sequence ID" value="ACL29232"/>
        <property type="gene ID" value="BLA_0940"/>
    </dbReference>
    <dbReference type="GeneID" id="66533446"/>
    <dbReference type="KEGG" id="bla:BLA_0940"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.983"/>
    <dbReference type="HOGENOM" id="CLU_027938_4_0_11"/>
    <dbReference type="OMA" id="MAWFFTG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="34"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="246" mass="27262" checksum="6ADDA053A779746A" modified="2009-03-03" version="1">MLYWFFMRTLGPVARHRFKPVAEGLQNIPRTGGGIIAANHLAVIDDALLPLTCPRMIHFMGKAEYFEGKGIKGKFKKWWFTSVGVFPVDRSGGSKSLGALEHAREIIEEGHLFGIHIEGTRSPDGRLYKGHTGAARLALETGCPIIPAAIIGSRELQKPGQVIPGKGHSKVIYGEPIEVEKTPSDEVTHERLRELTDEITRRIQAMSGQEYVPEYAQVVKQQMKEEQDVLDSAGAEAAADLEREHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTD7</accession>
    <name>B8DTD7_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Na(+)/H(+) antiporter NhaA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Sodium/proton antiporter NhaA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">nhaA</name>
        <name evidence="9" type="ordered locus">BLA_0976</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29251"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217643.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0976"/>
    <dbReference type="EnsemblBacteria" id="ACL29266">
        <property type="protein sequence ID" value="ACL29266"/>
        <property type="gene ID" value="BLA_0976"/>
    </dbReference>
    <dbReference type="GeneID" id="66533411"/>
    <dbReference type="KEGG" id="bla:BLA_0976"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1019"/>
    <dbReference type="HOGENOM" id="CLU_015803_0_0_11"/>
    <dbReference type="OMA" id="MGLMLRC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015081">
        <property type="term" value="F:sodium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006885">
        <property type="term" value="P:regulation of pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01844">
        <property type="entry name" value="NhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023171">
        <property type="entry name" value="Na/H_antiporter_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004670">
        <property type="entry name" value="NhaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30341">
        <property type="entry name" value="PTHR30341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06965">
        <property type="entry name" value="Na_H_antiport_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00773">
        <property type="entry name" value="NhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0050">Antiport</keyword>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL29266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="466" mass="49997" checksum="479E5B6636BEF1E6" modified="2009-03-03" version="1">MSNRQRGVWASIRKVAASDRISGLIMLGFALLGLVLANLPATYHWFEELSHFHLGIPGTNIDMGLGHWAQDGLLTIFFLVVGLELRQELTTGSLSNVRAAAVPMLCAVGGMLVPPVLFVAVISLFSNFGAGDPGSLIIANGSMFSFAETAHGWAIPTATDIAFSLAVLALFAKALPGSIRAFLMTLATVDDLLAIILIAVFFSSLNAWYWFVGIAICAVAWYFLVRMKKVPWFGVAVIGILAWVMMYEAGVHPTLAGVLVGLLTPARAMYGERSPRAERYADKLQPFSALLALPIFAFFATGVHFDSITPMLLVSPVVIAIIVALFVGKPLGIMATAWLSTHIGPFAMPKGLRVRDMFPASIACGIGFTVSFLIASLAYANAELSAEARFGVLLGSLVAAAVSAVLLSRQSARFARMDSVEERLAAMERPLEATRTLRDGTVVVSQTMGRDAEQDLAQLKEEDSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTE4</accession>
    <name>B8DTE4_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0102 protein BLA_0983</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0102 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0983"/>
    <dbReference type="EnsemblBacteria" id="ACL29273">
        <property type="protein sequence ID" value="ACL29273"/>
        <property type="gene ID" value="BLA_0983"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0983"/>
    <dbReference type="HOGENOM" id="CLU_115353_2_1_11"/>
    <dbReference type="OMA" id="RNWRCGR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00048">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003509">
        <property type="entry name" value="UPF0102"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34039">
        <property type="entry name" value="PTHR34039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02021">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00252">
        <property type="entry name" value="TIGR00252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="125" mass="14097" checksum="37B672B7E9C39677" modified="2009-03-03" version="1">MLLAPDLTAKQIGSLGERLCRAWLIEHHWHVLACNWHCRFGEIDIIALTSHSTIVFVEVKTRRSTSCGIPEEAVHAAKQMRVRRAAICWLGEHGSTIRHIGVRFDVIAVTVTPTDVFIHHVPEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTE7</accession>
    <name>B8DTE7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type cobalt transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cbiO</name>
        <name evidence="5" type="ordered locus">BLA_0986</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0986"/>
    <dbReference type="EnsemblBacteria" id="ACL29276">
        <property type="protein sequence ID" value="ACL29276"/>
        <property type="gene ID" value="BLA_0986"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0986"/>
    <dbReference type="HOGENOM" id="CLU_000604_86_7_11"/>
    <dbReference type="OMA" id="LAYGMEQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="274"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="311"/>
            <end position="318"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="511" mass="56469" checksum="B81E0F92A4D65B88" modified="2009-03-03" version="1">MTDVITVMNLGWQYAPSSAHGTPRGALHDVSCYVAEGTLAGIVGPTGSGKSTLAQALTGIIPHILDGTLTGFIRVAGMNVKSTSVSNISAKVGYVPQNPVDLFVTNEVENEIAFPLENRGVAPDEIRSRVDEVLDRLHIEGLRHRDPRMLSEGEMMRVAIGSAIAAEPEVLILDEVLAVLDEDGAQDLYAILDDLMKRNHTSVVMIDLDTRWLREHADSVLVMVGGEVIRRTTREVFLREASLLESVGVSRSRDDHTPLTIARLEPQDVTDPIIIFDHVYYLHPHSENSDAPQLRDVNLRIPRGSFVGVVGPNGSGKTTLLSMMNSQILPSRGHVIVDENDTAECRVRRMAREVAYLDQDPLHMMLTRNVRKEIEFAPRALGVPAQEVNKRVNALIRAFDLFDIEDADPIRLSTGQTRLVALASTLATQAPILVLDEPVSGLDYRLKTKFMTLVRDLNKQGITVIMASNDDDLVERYCTHALRMEEGRIVDFGPLHSAQLRSLDHDQEGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTE8</accession>
    <name>B8DTE8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobalt transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_0987</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217661.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29277">
        <property type="protein sequence ID" value="ACL29277"/>
        <property type="gene ID" value="BLA_0987"/>
    </dbReference>
    <dbReference type="GeneID" id="66533400"/>
    <dbReference type="KEGG" id="bla:BLA_0987"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1030"/>
    <dbReference type="HOGENOM" id="CLU_056469_2_3_11"/>
    <dbReference type="OMA" id="IRAYKMS"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="267" mass="29938" checksum="AC5688AF37382462" modified="2009-03-03" version="1">MRSQFYVPVDGWLNRVDVRVKLFTMIAVIVMCSIWGNWVFLTAMLLAEHLFLLSTRIPARKTLKVWSFFLPVIVIVFCIMLLTVHLPGWTLWRWGSWLVTSGTMDLCAVVALRIADIVFAVFTVLFTTSRAAWISGLAGLGLPYTAGAAVTDAIQWLPTYAATVHDLVLTQHIRGRYARIGKHNPLTRTAAWCSAHARAIIAAPAHLSHLNRARSITALAHGAHIDRMGAKRTYLHPAHMRLTDWMLLILVLVYIAAVIVMMVVFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTH9</accession>
    <name>B8DTH9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_1018</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29308">
        <property type="protein sequence ID" value="ACL29308"/>
        <property type="gene ID" value="BLA_1018"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1018"/>
    <dbReference type="HOGENOM" id="CLU_1657392_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="159" mass="17578" checksum="C7A4FF3A94B1B7E2" modified="2009-03-03" version="1">MALTHVLMAADVVGALLVPTLAARLLDKGTAAMSFHAMTVTALQMIAASLDMSVFDFRQLGTASMVTRTMSDVVNIQVAITDVIMMMLPVPFIFVVALTFAFSLDTVLDNEANNLSVGQRQLLTIARVFLADPACSFSMRRQARWTPARSRRLQRRWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTK1</accession>
    <name>B8DTK1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell envelope-related transcriptional attenuator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1042"/>
    <dbReference type="EnsemblBacteria" id="ACL29330">
        <property type="protein sequence ID" value="ACL29330"/>
        <property type="gene ID" value="BLA_1042"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1042"/>
    <dbReference type="HOGENOM" id="CLU_945483_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LytR_cpsA_psr" evidence="2">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="294" mass="32042" checksum="40B3F45C418AB8B8" modified="2009-03-03" version="1">MTKPKHGPCSLISVPRDSLVQVGDQMLKINAVMQVFGKKELVTQVESITGQHIDHVAKLTFGGLTKVVDALGGVELCYDQDVDDEKSELHWKSGCHVVDGRTALAFSRMRYSDPRSDFGRSDRQRQVIGAIAQKATAKSTLLNIGKLKKVGEAALGSLTVDDKSTPWTMLQMLLAFRDASGSNGITGSLYWTDPGYYVDGVGSSVLLDNQKNLELFKQLHDGDHAPGQWAQPPNNNSYPHTRVALDSPRYRRIVDAWALKHHIGRCAPQSAGNGGGTRDTSCVQPCLLSPRSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTL2</accession>
    <name>B8DTL2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Possible XylR-type repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219344.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="SMR" id="B8DTL2"/>
    <dbReference type="STRING" id="442563.BLA_1053"/>
    <dbReference type="EnsemblBacteria" id="ACL29341">
        <property type="protein sequence ID" value="ACL29341"/>
        <property type="gene ID" value="BLA_1053"/>
    </dbReference>
    <dbReference type="GeneID" id="66532882"/>
    <dbReference type="KEGG" id="bla:BLA_1053"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1101"/>
    <dbReference type="HOGENOM" id="CLU_036604_13_2_11"/>
    <dbReference type="OMA" id="FFIRHQQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="411" mass="44157" checksum="29AC05817EDD708D" modified="2009-03-03" version="1">MATLKRINQDDLRNHNLSVVLNQVLRSPQPLSRADLAKATGLTKATMSLLVSLLIEHGVLREGVPLVQAVYGRPSTPLIIAGGRVCGIGIQINTDGYGYTVLDLDGSTVAERWVDRDLHEVDADEIFADLDAMLLDQEQTLREQGYILAGTGIALPGLVTEDAHLIVARNLGWENIDLMQYDVIKRLNVVAGNESNMAATAHLPGYATQVHDEGMVGPDGSFIYVSTDIGIGGAIVRDGKVVDGGHGFAGEIGHLSVQLDGPQCRCGRHGCLEVYAGRRSMVERAGLASGDAAASQQAIDMFTQAVFDGAEPMHNVYLKAFGAMVSAIVSTINLSDVDTVIIGGCWAQLSAEERERMQAEVQRQILARDKVEAHILLTRDMRRPALIGAAQIGLRKFVDNPLAYLTADSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTP1</accession>
    <name>B8DTP1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease protein of ABC transporter system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BLA_1082</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218787.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1082"/>
    <dbReference type="EnsemblBacteria" id="ACL29370">
        <property type="protein sequence ID" value="ACL29370"/>
        <property type="gene ID" value="BLA_1082"/>
    </dbReference>
    <dbReference type="GeneID" id="66532908"/>
    <dbReference type="KEGG" id="bla:BLA_1082"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1135"/>
    <dbReference type="HOGENOM" id="CLU_019602_1_2_11"/>
    <dbReference type="OMA" id="VFEYINL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="70"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="291"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="328" mass="36405" checksum="B98739C380B98781" modified="2009-03-03" version="1">MPHHVEHDSEGLPIPNRIKAKPVKRPGQIVAAIIVVIFAAMIVKGLITNPRFEWNVVWKYLFNERVLEGVGYTLLLTVISMVVAIVLAVVLAVMRKSVNPVLRGVSWFYIWFFRGTPVYTQLVFWGLFAVLIPRLSLGIPLTSVEFWSIDSQAIITAFNAAWIGLALNEAAYLAEIVRAGLDAVDPGQEEAAKALGMKRSMIMRRVILPQAMRIIIPPTGNETIGMLKTTSLVLAVPFTLDLQYATNAIANRIYKPIPLLLVASIWYLFITSILMVIQSMLEKHFGRGFQARPVGPKGKQPPLPGKTDGEPKDDVNKTNQAEFMGYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTP9</accession>
    <name>B8DTP9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Solute binding protein of ABC transporter system for peptides</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_1090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1090"/>
    <dbReference type="EnsemblBacteria" id="ACL29378">
        <property type="protein sequence ID" value="ACL29378"/>
        <property type="gene ID" value="BLA_1090"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1090"/>
    <dbReference type="HOGENOM" id="CLU_017028_7_3_11"/>
    <dbReference type="OMA" id="KESPWVP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="129"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="576" mass="63061" checksum="9F4BED88FB12A680" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTQ1</accession>
    <name>B8DTQ1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable ABC transporter permease protein for peptides</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_1092</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218803.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1092"/>
    <dbReference type="EnsemblBacteria" id="ACL29380">
        <property type="protein sequence ID" value="ACL29380"/>
        <property type="gene ID" value="BLA_1092"/>
    </dbReference>
    <dbReference type="GeneID" id="66532918"/>
    <dbReference type="KEGG" id="bla:BLA_1092"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1146"/>
    <dbReference type="HOGENOM" id="CLU_028518_5_2_11"/>
    <dbReference type="OMA" id="RAWWVVS"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="86"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="294" mass="31304" checksum="629206D22F9295BF" modified="2009-03-03" version="1">MNRQSVRTHFRRVGIVVSTMWSRGTGRFSLIVLGLWVLVSLVSLFWTPRSLWQTDGYNVWAKPSREHWLGTDGTGADVLSWLMAGSRTNLAIVVLTVCFALAFGLLLVSLMVSHSTLLANGTVVAIDALISIPTVLIALMLAVPLGASILGIVLACGFGYGLNLARVARPQAMLSARSLYVESALSNGASAARVFFTHVLTNIRPVVTVQCSLAAGTAVLAETGLTYLGVGVPSGVPSWGYSLASSVKFITIYPLTVVWPGLIVTVVVMALNLFGDALHDAADPLSNPRLRRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTQ8</accession>
    <name>B8DTQ8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218813.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1099"/>
    <dbReference type="EnsemblBacteria" id="ACL29387">
        <property type="protein sequence ID" value="ACL29387"/>
        <property type="gene ID" value="BLA_1099"/>
    </dbReference>
    <dbReference type="GeneID" id="66532925"/>
    <dbReference type="KEGG" id="bla:BLA_1099"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1152"/>
    <dbReference type="HOGENOM" id="CLU_013985_3_6_11"/>
    <dbReference type="OMA" id="FIDYLAH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="185" mass="20805" checksum="080E37F02A66CEE0" modified="2009-03-03" version="1">MPTLHTERLVLRPWRESDAATLYEYAKNPNIGPIAGWPPHQSIEESLDVIRNVFDGPEDYAIALADDPDTAIGAISLKLAGNSDFFPANDTTQAEMGFWIGEPFWGNGYIPEAARELLRRGFENLGLSAIWCAYYEGNTKSARTQEKIGFEPIRVTQNVPVPLLGETRTEHVNRMTREQWETLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTR8</accession>
    <name>B8DTR8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Possible type I restriction-modification system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218823.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1109"/>
    <dbReference type="EnsemblBacteria" id="ACL29397">
        <property type="protein sequence ID" value="ACL29397"/>
        <property type="gene ID" value="BLA_1109"/>
    </dbReference>
    <dbReference type="GeneID" id="66532932"/>
    <dbReference type="KEGG" id="bla:BLA_1109"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1162"/>
    <dbReference type="HOGENOM" id="CLU_011736_6_1_11"/>
    <dbReference type="OMA" id="YVFRRAI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="DUF1524"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="DUF262"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="DUF1524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="DUF262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF262" evidence="1">
        <location>
            <begin position="17"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1524" evidence="2">
        <location>
            <begin position="438"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="649" mass="75025" checksum="F2572E7CFFA75DEE" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTT7</accession>
    <name>B8DTT7_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="5">ATase</shortName>
            <ecNumber evidence="5">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
            <shortName evidence="5">GPATase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">purF</name>
        <name evidence="10" type="ordered locus">BLA_1128</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="5"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218848.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1128"/>
    <dbReference type="MEROPS" id="C44.001"/>
    <dbReference type="EnsemblBacteria" id="ACL29416">
        <property type="protein sequence ID" value="ACL29416"/>
        <property type="gene ID" value="BLA_1128"/>
    </dbReference>
    <dbReference type="GeneID" id="66532952"/>
    <dbReference type="KEGG" id="bla:BLA_1128"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1182"/>
    <dbReference type="HOGENOM" id="CLU_022389_3_3_11"/>
    <dbReference type="OMA" id="ENAQPTF"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 6 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="12"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5 7">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL29416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="518" mass="56868" checksum="5D097F0A9D2382CD" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTV3</accession>
    <name>B8DTV3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Possible low specificity-threonine aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tal</name>
        <name evidence="4" type="ordered locus">BLA_1144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218872.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1144"/>
    <dbReference type="EnsemblBacteria" id="ACL29432">
        <property type="protein sequence ID" value="ACL29432"/>
        <property type="gene ID" value="BLA_1144"/>
    </dbReference>
    <dbReference type="GeneID" id="66532968"/>
    <dbReference type="KEGG" id="bla:BLA_1144"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1200"/>
    <dbReference type="HOGENOM" id="CLU_049619_1_0_11"/>
    <dbReference type="OMA" id="ETDCEVF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="341" mass="37721" checksum="3A39D8936DEC464D" modified="2009-03-03" version="1">MLSFENDYSSTAAPQIVARMQAMANEQNSGYGKDQYCDAAANKIRKACDAAQADVWFLVGGTQTNQTVLSAITPQYAGVVCPESAHINTHEAGAIEATGHKVLALPQHDGKITGEQLDEYCQSFENDLNHEHMVYPGCVYISQPTEYGTVYTREELASISQVAHDHNLPLYVDGARLGMALTADMNDVQLPDLARLADVFTIGGTKCGTMFGEAVVFPRGNSPRNFTTIVKQHGALLAKGWLLGLQFDTLFTDDLYFKLAKHANAEADKIRKALFEKHYDIEYISQTNQIFIVVTTQRAQELTKSVKLGFMEQVDADHVMLRICTSWATTDEQVDELIKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTV8</accession>
    <name>B8DTV8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218879.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1149"/>
    <dbReference type="EnsemblBacteria" id="ACL29437">
        <property type="protein sequence ID" value="ACL29437"/>
        <property type="gene ID" value="BLA_1149"/>
    </dbReference>
    <dbReference type="GeneID" id="66532974"/>
    <dbReference type="KEGG" id="bla:BLA_1149"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1206"/>
    <dbReference type="HOGENOM" id="CLU_077680_3_1_11"/>
    <dbReference type="OMA" id="PIATDFY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="224" mass="25700" checksum="D07C564C5770BA5B" modified="2009-03-03" version="1">MVRSRTAQLIFQSFYCAFGIVGILGSFGMYDGSFDNVFYVYFTNLSNYLCIAVMFFELVQTANRKQDGYVKLSPALKFISVTAILLTFFVFNLLLANAPDRNPLENFKVTSITFHVVLPLMFVADWLLFYEHRKVKWTYPLYSTVFPLVYLAFVYMRAWLVNFDTAVPKLYPYFFIDANQQGIAGVVRWCLILLAAFIVLGYILMAVDRMMPAAKESTPIDSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTV9</accession>
    <name>B8DTV9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29438">
        <property type="protein sequence ID" value="ACL29438"/>
        <property type="gene ID" value="BLA_1150"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1150"/>
    <dbReference type="HOGENOM" id="CLU_1431994_0_0_11"/>
    <dbReference type="OMA" id="VRMSMSE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="194" mass="20920" checksum="52C9E7FDF4AD300E" modified="2009-03-03" version="1">MQGVRMSMSEEIKDSRITDALANRRSVIIVGRATIAAKLALFESLLANLPESARLGVIDESGALAEIPENATVIDAKLKGVDAIHRIIRDDKLDTIACPSMRRGDIVRMLMDVSGQENGQVLMINGNIDDATQTLTSDLPMILLKSSPSGHTEFSDAAIKAMNPVVIELSADDSIRTVTEVDLHAEGLNTIDVR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-01-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTX7</accession>
    <name>PUP_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Prokaryotic ubiquitin-like protein Pup</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Bacterial ubiquitin-like modifier</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pup</name>
        <name type="ordered locus">BLA_1168</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Strongly interacts with the proteasome-associated ATPase ARC through a hydrophobic interface; the interacting region of Pup lies in its C-terminal half. There is one Pup binding site per ARC hexamer ring.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The N-terminal unstructured half of Pup provides a signal required to initiate unfolding and degradation by the proteasome but is not needed for pupylation, while the C-terminal helical half of Pup interacts with ARC to target proteins to the proteasome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic ubiquitin-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218910.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DTX7"/>
    <dbReference type="SMR" id="B8DTX7"/>
    <dbReference type="STRING" id="442563.BLA_1168"/>
    <dbReference type="EnsemblBacteria" id="ACL29456">
        <property type="protein sequence ID" value="ACL29456"/>
        <property type="gene ID" value="BLA_1168"/>
    </dbReference>
    <dbReference type="GeneID" id="66532993"/>
    <dbReference type="KEGG" id="bla:BLA_1168"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1226"/>
    <dbReference type="HOGENOM" id="CLU_183816_0_0_11"/>
    <dbReference type="OMA" id="PQEFAHT"/>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070490">
        <property type="term" value="P:protein pupylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02106">
        <property type="entry name" value="Pup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008515">
        <property type="entry name" value="Ubiquitin-like_Pup"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05639">
        <property type="entry name" value="Pup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03687">
        <property type="entry name" value="pupylate_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-1017">Isopeptide bond</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="chain" id="PRO_0000390570" description="Prokaryotic ubiquitin-like protein Pup">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="ARC ATPase binding" evidence="1">
        <location>
            <begin position="27"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="cross-link" description="Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-? in acceptor proteins)" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="71" mass="7656" checksum="29FE8969EB1AD69F" modified="2009-03-03" version="1">MPSASGHHQIPAETQRHDDDQTQETAQGLSAAAMLAQEQADDLDAILDDIETVLETNAEEYVSSFVQKGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTX9</accession>
    <name>B8DTX9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein HB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hup</name>
        <name evidence="2" type="ordered locus">BLA_1170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218914.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1170"/>
    <dbReference type="EnsemblBacteria" id="ACL29458">
        <property type="protein sequence ID" value="ACL29458"/>
        <property type="gene ID" value="BLA_1170"/>
    </dbReference>
    <dbReference type="GeneID" id="66532995"/>
    <dbReference type="KEGG" id="bla:BLA_1170"/>
    <dbReference type="HOGENOM" id="CLU_105066_3_1_11"/>
    <dbReference type="OMA" id="PAHEGIN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="93" mass="9922" checksum="3547BA66A75AE1DC" modified="2009-03-03" version="1">MAYNKSDLVAKISQKSGLTKAQAEAAVNAFRDVFIEAMKNGEGLKLTGLLSAERVKRAARTGRNPRTGETIEIPATYGVRISAGSLLKKAVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTZ0</accession>
    <name>B8DTZ0_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Uracil-DNA glycosylase</fullName>
            <shortName evidence="8">UDG</shortName>
            <ecNumber evidence="4 8">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">ung</name>
        <name evidence="11" type="ordered locus">BLA_1181</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="4 8"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218931.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1181"/>
    <dbReference type="EnsemblBacteria" id="ACL29469">
        <property type="protein sequence ID" value="ACL29469"/>
        <property type="gene ID" value="BLA_1181"/>
    </dbReference>
    <dbReference type="GeneID" id="66533006"/>
    <dbReference type="KEGG" id="bla:BLA_1181"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1241"/>
    <dbReference type="HOGENOM" id="CLU_032162_3_1_11"/>
    <dbReference type="OMA" id="WEAVTEQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="PTHR11264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="10">
        <location>
            <begin position="54"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL29469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="239" mass="26309" checksum="1CFBA2B01DBC0658" modified="2009-03-03" version="1">MTEIKPLEELMDPGWAEALRPVEPQIRHMGRLLRERIGHGEHIAPASRNILRAFTIPFDSIRVLIVGQDPYPTPGYAVGLSFSVAPNVHPLPKSLVNIFKELEDDLHVPPPCNGDLTPWTHRGVELLNRCLTVEIGRPNSHQNLGWEPVTDCAVRALNNRVDEHGKPKPLAAILWGRNAQTLEPLLTNAAIIKSAHPSPLSASRGFFGSHPFSRANAALKQMGAEPVDWSLPSSDCPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTZ8</accession>
    <name>B8DTZ8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218159.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1189"/>
    <dbReference type="EnsemblBacteria" id="ACL29477">
        <property type="protein sequence ID" value="ACL29477"/>
        <property type="gene ID" value="BLA_1189"/>
    </dbReference>
    <dbReference type="GeneID" id="66533015"/>
    <dbReference type="KEGG" id="bla:BLA_1189"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1250"/>
    <dbReference type="HOGENOM" id="CLU_035969_0_0_11"/>
    <dbReference type="OMA" id="PEWVPWS"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021391">
        <property type="entry name" value="DUF3027"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11228">
        <property type="entry name" value="DUF3027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="376" mass="41255" checksum="30A28206D73F6743" modified="2009-03-03" version="1">MATSEFDPIALARAEAIDTAHEPEDVGEFVTSEAHDDGVTDFRFEALMKGYEGWQWSVTLYHDVELDHWTIDESSLIPTDKALLPPKWVPWKDRLLPSDLSVTDSIGTPEDDERLDDGIGIDEAVSRTEELNAEQQAVETVQAQEGGSPDEQADALTAVEDVVEAVEELDLSRRHVLSELGQTQTAQRWYEGPHGPKSLSTKTADGNLCSTCGFFIPLAGSLKTMFGVCANRWSPDDGKVVSVDHGCGEHSEIRPPEPSRMWVQTKPAYDDLHIDVVAQHGRDERKDEELLESLDEVDAESLAGLKQKALDMDDDMPDTSSFGIGSVSPQDFSGEEPEADSTVERSAAKEVCEDEDAEQIDSMCTSETVIAEEAGE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU04</accession>
    <name>SYH_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="1">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisS</name>
        <name type="ordered locus">BLA_1195</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619961.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DU04"/>
    <dbReference type="SMR" id="B8DU04"/>
    <dbReference type="STRING" id="442563.BLA_1195"/>
    <dbReference type="EnsemblBacteria" id="ACL29483">
        <property type="protein sequence ID" value="ACL29483"/>
        <property type="gene ID" value="BLA_1195"/>
    </dbReference>
    <dbReference type="GeneID" id="66533020"/>
    <dbReference type="KEGG" id="bla:BLA_1195"/>
    <dbReference type="HOGENOM" id="CLU_025113_3_0_11"/>
    <dbReference type="OMA" id="YQIQKVW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000199115" description="Histidine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <sequence length="466" mass="51436" checksum="6EC78AA492DA79BC" modified="2009-03-03" version="1">MAKGASISGFPEWLPAERVVEQRVIDTLREVFELNGFIGIETRAVEQGSSLLKKGETSKEIYLLSRLQEVGHESDIPVEQRLGLHFDLTVPLSRYVVEHSGALPFPFKRWQIQKVWRGERPQEGRFREFVQADIDVVGDGTLPSHYEVELPLVMVNALERLREFGLPKATVHANNRKLSEGFYRGLGLTDIEGVLREIDKLDKIGPQAVTDLLVETCGATEAQANACLELAQVTAEDGQELIEKFNGLCEIHHIPFDGDEYAMAKEGLDTLSMIIDEARRIRPGSVMADLKIARGLDYYTGSVYETFLEGASDLGSICSGGRYDNLATQGNRKYPGVGLSIGLSRLVSYMLHRAGATASRMSPACVLVAVWDEENRGDSNAIANTLRSRGIAADVAPTAAKLGKQIKYADKLGIPYVWFPNENPENDGSDEVKNIITGDQRPADAQSWQPDTVYAQQTVSINADNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU08</accession>
    <name>B8DU08_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamate-binding protein of ABC transporter system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gluB</name>
        <name evidence="7" type="ordered locus">BLA_1199</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1199"/>
    <dbReference type="EnsemblBacteria" id="ACL29487">
        <property type="protein sequence ID" value="ACL29487"/>
        <property type="gene ID" value="BLA_1199"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1199"/>
    <dbReference type="HOGENOM" id="CLU_019602_18_4_11"/>
    <dbReference type="OMA" id="IFATYSI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867533" evidence="5">
        <location>
            <begin position="26"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="6">
        <location>
            <begin position="31"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="271" mass="29215" checksum="94D503956EC62833" modified="2009-03-03" version="1">MARKAIAMVCAASALFGMAACGSSSADGEKKIRIGIKYDQPGLGFKKSGTFEGFDVDVARYVANQLGYTDAEIEFLEAPSKQREAMLQNGDVDMILATYSITDERKKAVSFAGPYFVAGQDLMVRADDHSINGPEDLNGKRLCSVTGSTSAKVVKERFAKEVQLMEQPGYAECATALFSGIVDAVTTDDIILAGLASASRGKLRVVGKPFTQEYYGVGIRKGDTAFAKQINAAIEDMIKSGEWERAIEKNTEGTDYQPDPTYNPPTPDEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU39</accession>
    <name>B8DU39_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase-like deacylases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218106.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1230"/>
    <dbReference type="EnsemblBacteria" id="ACL29518">
        <property type="protein sequence ID" value="ACL29518"/>
        <property type="gene ID" value="BLA_1230"/>
    </dbReference>
    <dbReference type="GeneID" id="66533054"/>
    <dbReference type="KEGG" id="bla:BLA_1230"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1293"/>
    <dbReference type="HOGENOM" id="CLU_029469_2_0_11"/>
    <dbReference type="OMA" id="HITIPGF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="200"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="455" mass="48695" checksum="8BE4862B3AF23611" modified="2009-03-03" version="1">MILTADQIRARVDADWPQILGVVEDRIALRPISAHGINGEHMRKSAEYVANKLREVGVDAKAVQARDKDGNPSAWEVIGSLEVNPNAPTVLLYAHHDVQPVPDEKEWDTAPFEATLKGDRLYGRGACDDAGGIAIHYGALRALGDQLGVNIKVFIEGEEEMGSASFIPFIEAHHDEFDSDVIIVADSGNWAPDVPSLTTSLRGNATCDVHVKVLGHPVHSGQYGGPVLDANTLASMLIAKMYDEKGELAIPGLMEGEPIGGLQRDLDEADMRAAAGVVDSFTLVGTGSLASRLWTKPSATVIGFDAHPVKDSFNVISPETTFRVSLRVAPQQDPHVAMDAMVDFFEKNAPFGAEVHVEPLEAGMGWAMNPDCEATQDALTSLKEAFGIDPVNKGEGGSIPFIPELQKIFPDAQVLVTGPEDPISNAHSPNESVSVSGLRKDVVAEALLLDKLGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU46</accession>
    <name>B8DU46_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP binding protein of ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BLA_1237</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218096.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1237"/>
    <dbReference type="EnsemblBacteria" id="ACL29525">
        <property type="protein sequence ID" value="ACL29525"/>
        <property type="gene ID" value="BLA_1237"/>
    </dbReference>
    <dbReference type="GeneID" id="66533059"/>
    <dbReference type="KEGG" id="bla:BLA_1237"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1300"/>
    <dbReference type="HOGENOM" id="CLU_000604_38_0_11"/>
    <dbReference type="OMA" id="NWGYRHA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="633"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="658"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="697"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="823"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="17"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="337"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="369"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL29525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="851" mass="91755" checksum="45DA6413C5A5990C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU60</accession>
    <name>B8DU60_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Argininosuccinate synthase</fullName>
            <ecNumber evidence="2 9">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">argG</name>
        <name evidence="10" type="ordered locus">BLA_1251</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="2 9"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218073.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1251"/>
    <dbReference type="EnsemblBacteria" id="ACL29539">
        <property type="protein sequence ID" value="ACL29539"/>
        <property type="gene ID" value="BLA_1251"/>
    </dbReference>
    <dbReference type="GeneID" id="66533073"/>
    <dbReference type="KEGG" id="bla:BLA_1251"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1314"/>
    <dbReference type="HOGENOM" id="CLU_032784_4_2_11"/>
    <dbReference type="OMA" id="QCEVVTF"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="Argininosuccinate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="PTHR11587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="SSF69864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="10"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL29539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="412" mass="45676" checksum="D6494AAA7816823E" modified="2009-03-03" version="1">MSDKNRIVLAYSGGLDTSVAIPYLKDRTGKDVVAVSLDVGQGGESLETIKERALACGAVEAYIVDARDEFANEYCMQALKANAMYEGVYPLVSAISRPLITKHLVRAAHQFGADTIAHGCTGKGNDQVRFEVSIQSIDPELKAISPIRDLSLTRDVEIAYANEHDLPIVQTEKSPFSIDQNVWGRAIETGFLEDPWNAPTKDCYSYTDDPDFPPVEDEVVIEFKEGVPVKIDGREVTPLQAIEEMNRRAGAQGIGRVDLIEDRLVGIKSRELYEAPGAIALITAHEELENMCLEREQHRIKRGIDKRWAELVYDAQWFSPAVHSLNAFINDTQRYVSGEIRMVMHGGRAVVVGRRSDSSLYDYNLATYDSGDTFDQNASNGFIEIYGLPTKVAAARDVRFGNGIEVPQNDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU83</accession>
    <name>B8DU83_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Possible magnesium and cobalt transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">corA</name>
        <name evidence="7" type="ordered locus">BLA_1275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269082.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1275"/>
    <dbReference type="EnsemblBacteria" id="ACL29562">
        <property type="protein sequence ID" value="ACL29562"/>
        <property type="gene ID" value="BLA_1275"/>
    </dbReference>
    <dbReference type="GeneID" id="66533100"/>
    <dbReference type="KEGG" id="bla:BLA_1275"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1337"/>
    <dbReference type="HOGENOM" id="CLU_007127_8_1_11"/>
    <dbReference type="OMA" id="GILHTDH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="316" mass="36373" checksum="6717FFA77FC5C4A8" modified="2009-03-03" version="1">MLRMFSTVDGQVRQISKPENGSWLALADPTDVELATVSQETGIDLADLRAPLDDEERSRVDVEDDYTMIIVDIPTVEERSGRDWYETIPLSIIVTKTMIITVCMQDTPVLHPFMEGTIRGFNTFMRSRFILQILYRNATMYLRYLRIIDRETDKLELRLRHSMQNREILMLLELSKTLVYFNTSLKSNEIVMEKLMTLTRIKQYPEDEDLLEDVITENKQAIEMANIYSGVLANMTDAFASIVSNNLNNVMRIFTMISITLSIPTLIFSMYGMNFQQGMIGMPLSDSKWGFLVIVLLACVLAGAVIWFLTRSRLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUB0</accession>
    <name>B8DUB0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_1302</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619994.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1302"/>
    <dbReference type="EnsemblBacteria" id="ACL29589">
        <property type="protein sequence ID" value="ACL29589"/>
        <property type="gene ID" value="BLA_1302"/>
    </dbReference>
    <dbReference type="GeneID" id="66533128"/>
    <dbReference type="KEGG" id="bla:BLA_1302"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OMA" id="ISMPAPD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="28"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="236" mass="25091" checksum="189D90CE13DBD8B9" modified="2009-03-03" version="1">MTKTFGSLTAVDKLNLTVAQGETFALLGVNGAGKTTTISMLCGLTKPTSGNAYLLGESVLTDAKRIKPQINLSPQETAVAPNLSVTENLRLIAGIYGQSAQQAKASTQQALDEFGLNAVASQKAHTLSGGMQRRLSIAMGLITNPKILFLDEPTVGLDIFARRELWNVIKGLKGRVTILLTTHYLEEVEALADRIAIMVAGRTIAIGTVAELKKQTGENNLEDAFVKLVGGNNELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUC1</accession>
    <name>B8DUC1_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10 11">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10 11">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 15" type="primary">rpe</name>
        <name evidence="15" type="ordered locus">BLA_1313</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10 13">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10 11">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10 11"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1313"/>
    <dbReference type="EnsemblBacteria" id="ACL29600">
        <property type="protein sequence ID" value="ACL29600"/>
        <property type="gene ID" value="BLA_1313"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1313"/>
    <dbReference type="HOGENOM" id="CLU_054856_2_1_11"/>
    <dbReference type="OMA" id="WLQVDGG"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="143"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="176"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="198"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 12">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ACL29600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="224" mass="24469" checksum="D4A284598C306D3A" modified="2009-03-03" version="1">MATMDIKIAPSILSADFCNLERDLERISNADMVHVDVMDHHFVPNLTIGEPVVKRICEVTDLPVDVHLMIDDPDRWAPGYAERGAHSVTFHMGATHAPVRLARQLHDMGCEAWFAVRPAEPVEPIFDILEEFDTILIMTVEPGFGGQKFLANQMGKVRRLRDEITRRGLDTNIQVDGGVSPKTAATVAQAGANILVAGSAVYGAADPAKAINEIRDTAAAAYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUE3</accession>
    <name>B8DUE3_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate--CoA ligase [ADP-forming] subunit alpha</fullName>
            <ecNumber evidence="2">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="2">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 7" type="primary">sucD</name>
        <name evidence="7" type="ordered locus">BLA_1337</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217963.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1337"/>
    <dbReference type="EnsemblBacteria" id="ACL29622">
        <property type="protein sequence ID" value="ACL29622"/>
        <property type="gene ID" value="BLA_1337"/>
    </dbReference>
    <dbReference type="GeneID" id="66533162"/>
    <dbReference type="KEGG" id="bla:BLA_1337"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1399"/>
    <dbReference type="HOGENOM" id="CLU_052104_0_0_11"/>
    <dbReference type="OMA" id="VIICITE"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA_binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="105"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2 3">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="305" mass="31363" checksum="F8ECF79DF9978F2E" modified="2009-03-03" version="1">MNVFIEDDAPVIVQGITGHQGMTHTARMLKANTNIVGGVNPRKAGTTLEFEDGNGVPVRVPVFATCQEAKDITGAKASVVFVPPRFAKDAVVEAVEAGFEVVVVITEGIPVADSAYFVELALSKGVRIVGPNCPGLLTLPESTDTHGVNLGIIPDGIVSRGPLGLVSKSGTLTYQLMGELSDIGFTACLGAGGDPIVGTTLLEALEAFEADPNTKAVMMIGEIGGNAEQDAAQWAAKNMTKPVVAYIAGFTAPEGKQMGHAGAIVSGGKGTAQDKQAALEAAGIRVGRTPSEAAQIMREVLSAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUF2</accession>
    <name>B8DUF2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipid A biosynthesis lauroyl acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_1346</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217951.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1346"/>
    <dbReference type="EnsemblBacteria" id="ACL29631">
        <property type="protein sequence ID" value="ACL29631"/>
        <property type="gene ID" value="BLA_1346"/>
    </dbReference>
    <dbReference type="GeneID" id="66533171"/>
    <dbReference type="KEGG" id="bla:BLA_1346"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1408"/>
    <dbReference type="HOGENOM" id="CLU_049421_3_1_11"/>
    <dbReference type="OMA" id="GMRSYMR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004960">
        <property type="entry name" value="LipA_acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30606">
        <property type="entry name" value="PTHR30606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03279">
        <property type="entry name" value="Lip_A_acyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="331" mass="37539" checksum="D5C898CB2B89D7C3" modified="2009-03-03" version="1">MFDRLMAWLARHPNALPERMVRGGFLAAADVTWALHIGSVRQLERNLAHVLSWRDGTDPDRRTLRKLSRKGMRSYFTYFSEAMTVGARSKEQLLARIHGSGDGFEAIKHQAGSEGTGSAPIAMGHQGNWDYDGFWAQFDVAPVTTVAEKLANREMLDAFVSIREHLGMTIFLTGTPKLTERLEEALRTPHTLVPLLADRDLSRHGEFVNAFGSFIRVARGPAAIAFDTGTPLFVVNTYREKLSGERRRLARTPYGYVCEVSGPIDVERYRSMPREEAIRCICQDWVDIWARGIAAHPEDWHMLQPIFLEDLDMERLKDVPEELRAQATMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUG1</accession>
    <name>B8DUG1_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">dnaJ</name>
        <name evidence="11" type="ordered locus">BLA_1355</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217936.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1355"/>
    <dbReference type="EnsemblBacteria" id="ACL29640">
        <property type="protein sequence ID" value="ACL29640"/>
        <property type="gene ID" value="BLA_1355"/>
    </dbReference>
    <dbReference type="GeneID" id="66533186"/>
    <dbReference type="KEGG" id="bla:BLA_1355"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1418"/>
    <dbReference type="HOGENOM" id="CLU_017633_0_7_11"/>
    <dbReference type="OMA" id="DLHCTVT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="3"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="10">
        <location>
            <begin position="131"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="144"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="161"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="187"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="201"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="131"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="343"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="355"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL29640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="382" mass="42325" checksum="92C397453994F74D" modified="2009-03-03" version="1">MADYYSVLGVERDATEEEIKRAYRKMSRKYHPDLAGPQFEEKFKEVNTAYEVLSDPEKRRMFDMGVDPNDPRGGAGYGGGQPFGGFDMGDVFGQFFDAFGGGTGNGPIPRSQPGRDQLEELTIDLRTAVFGAEQHLKFSTYGTCQNCEGTGSEHEEPPITCPTCHGSGYTQKVVRTLLGQMMTSVPCETCQGHGNIFQHPCTQCQGSGRVRTERDVVIPVPGGVQNDSRLRVPGQGEAGECNGQPGDLYVDITVRKDERFTRQGDDLHCWIRVPMTWAVLGHAMEIDSFDGKQQLDIPAGTQPEQTVEIKNLGMTKLNDKDQRGNLIVHINVQIPTKLSDSERSLMEQFAQQQKDEKPVRQSSQPATPQKRGFFSKIKDALG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-26" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUH3</accession>
    <name>WHIA_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable cell division protein WhiA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">whiA</name>
        <name type="ordered locus">BLA_1367</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in cell division and chromosome segregation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the WhiA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217922.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DUH3"/>
    <dbReference type="SMR" id="B8DUH3"/>
    <dbReference type="STRING" id="442563.BLA_1367"/>
    <dbReference type="EnsemblBacteria" id="ACL29652">
        <property type="protein sequence ID" value="ACL29652"/>
        <property type="gene ID" value="BLA_1367"/>
    </dbReference>
    <dbReference type="GeneID" id="66533198"/>
    <dbReference type="KEGG" id="bla:BLA_1367"/>
    <dbReference type="HOGENOM" id="CLU_053282_0_0_11"/>
    <dbReference type="OMA" id="CDAEAAW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043937">
        <property type="term" value="P:regulation of sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01420">
        <property type="entry name" value="HTH_type_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003802">
        <property type="entry name" value="Sporulation_regulator_WhiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023054">
        <property type="entry name" value="Sporulation_regulator_WhiA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039518">
        <property type="entry name" value="WhiA_LAGLIDADG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37307">
        <property type="entry name" value="PTHR37307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02650">
        <property type="entry name" value="HTH_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14527">
        <property type="entry name" value="LAGLIDADG_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00647">
        <property type="entry name" value="DNA_bind_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000376447" description="Probable cell division protein WhiA">
        <location>
            <begin position="1"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="282"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01420"/>
        </source>
    </evidence>
    <sequence length="320" mass="35026" checksum="9493028DDC309FC5" modified="2009-03-03" version="1">MALLDEVKSELSNIDGGSPAVQKAQVTSMLYFGRGFRKVQRESSTQIIVQPQFDSMEAAHWLQETIESLYKIPAALKSVDVKTPQGSMRRYAVDVGARAGFALAVRTGMIDPRLNRIVRGLPTDLSNGNIAQIKGVWRGAFMSAGVLSDPDKPSALEIICPNEETADSLIAMGQRLGIRAAKHTVRSSVRVHLSDPDAIERLLTMMGASSTVRDWTGKRPDTESHHRANRLANFDDANMRRSAKAAAEAVVKVQHAFDVLGDDIPQNLRAAGQLRIDHPDFSLEELGRAARPQISKDAVAGRIRRLLQRAEKAEQDAAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUJ2</accession>
    <name>B8DUJ2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217897.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1386"/>
    <dbReference type="EnsemblBacteria" id="ACL29671">
        <property type="protein sequence ID" value="ACL29671"/>
        <property type="gene ID" value="BLA_1386"/>
    </dbReference>
    <dbReference type="GeneID" id="66533216"/>
    <dbReference type="KEGG" id="bla:BLA_1386"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1450"/>
    <dbReference type="HOGENOM" id="CLU_024566_1_0_11"/>
    <dbReference type="OMA" id="CQGTVPQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="302" mass="33222" checksum="65EEC0DBEE287B20" modified="2009-03-03" version="1">MTGIFGAIIGDIVGSKYEANPIKTKHFPLFSNGCRFTDDTVMTCAVAEGIMNGGSADDFIDAMKKYGRMYPNAGYGPRFMRWLFSDSREPIGSFGNGSAMRISPCAWMMSCGFTARTGFMPIGGRELAERSITVTHDDPEGVRGGMAVADSIFLARYYFGGCRGEHERSLADDPAACRQRIEDHIIHEYGYNMSRSLGKIRSDYRFDATCQGSVPEAITCFLESTGFEDAIRNAVSLGGDSDTQAAIAASIAQAAYGIPDSIAEQALSYLPMPLRDVLTRWDAFYRDLDEPPLFFEHRPYNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUM2</accession>
    <name>B8DUM2_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 15">NAD(P) transhydrogenase subunit beta</fullName>
            <ecNumber evidence="6 15">7.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Nicotinamide nucleotide transhydrogenase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">pntB</name>
        <name evidence="18" type="ordered locus">BLA_1416</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 15">The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell inner membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the PNT beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="6 15"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217858.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1416"/>
    <dbReference type="EnsemblBacteria" id="ACL29701">
        <property type="protein sequence ID" value="ACL29701"/>
        <property type="gene ID" value="BLA_1416"/>
    </dbReference>
    <dbReference type="GeneID" id="66533245"/>
    <dbReference type="KEGG" id="bla:BLA_1416"/>
    <dbReference type="HOGENOM" id="CLU_007866_4_0_11"/>
    <dbReference type="OMA" id="KRGMSAG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:NAD(P)+ transhydrogenase (AB-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012136">
        <property type="entry name" value="NADH_DH_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034300">
        <property type="entry name" value="PNTB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02233">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000204">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="8 15" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14 15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0520">NAD</keyword>
    <keyword evidence="11 15" id="KW-0521">NADP</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 15" id="KW-1278">Translocase</keyword>
    <keyword evidence="10 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="PNTB" evidence="17">
        <location>
            <begin position="12"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ACL29701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="471" mass="49156" checksum="95E429EFA9AB05F0" modified="2009-03-03" version="1">MNTTPIDIIAWFAYLLSAVMFVMGLHYMNSPKTARKGNFISAAGMVVAVVMAFVKLFITGFENAIAIWLLIAGIIIGAVAGVASAKRVKMTDMPQLVSVFNTVGGGAAALVALNDILAGEGTPSIVVLITAGLGVMIGSVTFTGSLIAAGKLQGVKWVRNLSLPGKSFWNILFIVLMVASFVLLCVFPQQRLLWAILTTVFALCYGLVFVIPIGGADMPVVISVLNACTGTAVAMSGLAIDNVALIIAGALVGSAGVTLSVLMSKAMNRPLMSVLAGGFGGSNASAGDGEGPEGTMKETSADDLAVQLVYADKVIFVPGFGLAQAQAQRELADLGELLKEHGVEVEYAIHPVAGRMPGHMNVLLAEANVPYDELVDLDDINPQFPAANVSLVVGANDVTNPAARRPGTPVSGMPILDVDKSQNVVVMKRGRGKGYAGIENELYYEDNTQMLFGDAKQSLQSVIAAVKELLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUM5</accession>
    <name>B8DUM5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fadD</name>
        <name evidence="3" type="ordered locus">BLA_1419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217855.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="SMR" id="B8DUM5"/>
    <dbReference type="STRING" id="442563.BLA_1419"/>
    <dbReference type="EnsemblBacteria" id="ACL29704">
        <property type="protein sequence ID" value="ACL29704"/>
        <property type="gene ID" value="BLA_1419"/>
    </dbReference>
    <dbReference type="GeneID" id="66533248"/>
    <dbReference type="KEGG" id="bla:BLA_1419"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1483"/>
    <dbReference type="HOGENOM" id="CLU_000022_45_5_11"/>
    <dbReference type="OMA" id="GEGEKMP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="98"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="686" mass="76124" checksum="54D9EAB6A9A41D5E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUN5</accession>
    <name>B8DUN5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted metal-sulfur cluster biosynthetic enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217842.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1429"/>
    <dbReference type="EnsemblBacteria" id="ACL29714">
        <property type="protein sequence ID" value="ACL29714"/>
        <property type="gene ID" value="BLA_1429"/>
    </dbReference>
    <dbReference type="GeneID" id="66533259"/>
    <dbReference type="KEGG" id="bla:BLA_1429"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1493"/>
    <dbReference type="HOGENOM" id="CLU_091588_0_0_11"/>
    <dbReference type="OMA" id="AGACGCE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="1">
        <location>
            <begin position="87"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="190" mass="20451" checksum="D6316501ED940B81" modified="2009-03-03" version="1">MSDNLVPEPQSTIFDAVNAVVGNEDEAQAIIANPSLAKDILGNDDASAVKSECCGGHGVQSQDHECACRSDGIELKGVDEIGRATAADVKEALHQVIDPELGIDVIDLGLVYGIEIDELGRAIITMTLTTPACPLTDLIEDECASTLAGLVEEFRIDWTWTPRWTVDKITPEGRDQLAALGFNLDNMPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUP6</accession>
    <name>B8DUP6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217829.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29725">
        <property type="protein sequence ID" value="ACL29725"/>
        <property type="gene ID" value="BLA_1441"/>
    </dbReference>
    <dbReference type="GeneID" id="66533271"/>
    <dbReference type="KEGG" id="bla:BLA_1441"/>
    <dbReference type="HOGENOM" id="CLU_1207901_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="229" mass="25508" checksum="AE69B205AF0A9543" modified="2009-03-03" version="1">MDVRVHELQLTRARAEQLMDRQRKANAVANMQRRRAPELAYLEERRRQTIDFATLTIAGLSLLTVAVIVGRVYAMWMYAIACVGVVVCGFALISAVLLLLRGAVVNRAVIELSKAAVLARSRVGDDPDRAGQSQNDADTVRALFTGQAATEQEVEPCTKNYALNRRLEQNERAALEQLGRQADDAAREYQSVVGQVATLRGDTESSHAQELDLERQNKLFEAFVNEHGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUS2</accession>
    <name>B8DUS2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217793.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29751">
        <property type="protein sequence ID" value="ACL29751"/>
        <property type="gene ID" value="BLA_1469"/>
    </dbReference>
    <dbReference type="GeneID" id="66533299"/>
    <dbReference type="KEGG" id="bla:BLA_1469"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1537"/>
    <dbReference type="HOGENOM" id="CLU_1324321_0_0_11"/>
    <dbReference type="OMA" id="NGMLILI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025699">
        <property type="entry name" value="ABC2_memb-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13346">
        <property type="entry name" value="ABC2_membrane_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="206" mass="22656" checksum="8DAF6007134B22A3" modified="2009-03-03" version="1">MKGLFVRDAIWLGKQRMLLVCMLALTVFYLFSDLHAFGVAFLPLMLAMLVCRTVQNDVSRACRRMFFTMPFNTRDYLIEKYCGAIIPPMLLSLVLMALGTLSPQMAWNQVPVALVMVLATVSVTVAVEIPIILAFRDRAAVMRIVAMAVIFTICVLVVSVTNNQDILVALTSIPDGLLMLIGGVVCLVCTAASGSISHRLLSRAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUV1</accession>
    <name>B8DUV1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">30S ribosomal protein S1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsA</name>
        <name evidence="3" type="ordered locus">BLA_1498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217746.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1498"/>
    <dbReference type="EnsemblBacteria" id="ACL29780">
        <property type="protein sequence ID" value="ACL29780"/>
        <property type="gene ID" value="BLA_1498"/>
    </dbReference>
    <dbReference type="GeneID" id="66533330"/>
    <dbReference type="KEGG" id="bla:BLA_1498"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1568"/>
    <dbReference type="HOGENOM" id="CLU_015805_4_1_11"/>
    <dbReference type="OMA" id="WQQFART"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="36"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="123"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="209"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="294"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="493" mass="55220" checksum="2D68BC84F02A3927" modified="2009-03-03" version="1">MAENKAEVEKVAINDIGTVDDFIKAVDSTIKNFDDGDLVEGTVVKVDHDEVLLDIGYKTEGVIPSRELSIKKDVDPDDVVKVGDTIEALVVTKEDKEGRLILSKKRAQYERAWGDIEKIKENDGVVEGTVIEAVKGGLIVDIGLRGFLPASLVEMRRVRDLSPYIGQKIKAKVLELDKNRNNVVLSRRQYLEETQSEVRETFLSQLKKGQIREGVVSSIVNFGAFVDLGGVDGLIHVSELSWKHIDHPSEVVKVGDKVTVEVLDVDLDRERISLSLKATQEDPWQRFARTHVPGQIVRGKVTKIVQFGVFISVEDGIEGLVHISELANRHVENPETVVKPGEEVFVKVIDVDLDRRRISLSLKQANDSVDPNSEDFDPALYGMPAEYDEDGNYKYPEGFDPNTNEWIPGYEKQREEWEAQYASAHGLWELHKEFVRKELENAEASAQEDGQAPAKEEKVEETSNYSSESESNGTLADSDQLAALREQLLSEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUW8</accession>
    <name>B8DUW8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sir2-type regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_1515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1515"/>
    <dbReference type="EnsemblBacteria" id="ACL29797">
        <property type="protein sequence ID" value="ACL29797"/>
        <property type="gene ID" value="BLA_1515"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1515"/>
    <dbReference type="HOGENOM" id="CLU_023643_3_2_11"/>
    <dbReference type="OMA" id="EQCKKCR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="216" mass="23954" checksum="6E52BDB8EEF38129" modified="2009-03-03" version="1">MQVYDIDAFLTDKEAREYSWRWQKESPVWNAKPGKAHYALVDLEKAGMLSLIATQNFDALHEKAGNSPSKIVNLHGTIGTSHCMKCHAKYDTADIMARLDEEPDPHCHHQLPYRGNMPCNGLLKTDVVYFGEALPEGAMERSIRAAQQADELWVVGSTLEVFPAASIVPAAAQAGVPITIMNMGRTQYDSLATRLIHEDIAVALPELVQRTIADNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV30</accession>
    <name>B8DV30_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0026"/>
    <dbReference type="EnsemblBacteria" id="ACL28331">
        <property type="protein sequence ID" value="ACL28331"/>
        <property type="gene ID" value="BLA_0026"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0026"/>
    <dbReference type="HOGENOM" id="CLU_110454_2_2_11"/>
    <dbReference type="OMA" id="KMDTNRQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11537">
        <property type="entry name" value="NTP-PPase_RS21-C6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025984">
        <property type="entry name" value="DCTPP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12643">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029826">
        <property type="entry name" value="UCP029826_pph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="99" mass="11338" checksum="57DBFCA6B736FED1" modified="2009-03-03" version="1">MIHQFSADRDWQQFHAPANMAKSVSIEAGELLECFQWSDEPRDGDWEHVYEELADVMIYCIQMADVLDVDLDEIIRSKMAKNAKKYPVEASRGSSAKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV34</accession>
    <name>B8DV34_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0030"/>
    <dbReference type="EnsemblBacteria" id="ACL28335">
        <property type="protein sequence ID" value="ACL28335"/>
        <property type="gene ID" value="BLA_0030"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0030"/>
    <dbReference type="HOGENOM" id="CLU_354457_0_0_11"/>
    <dbReference type="OMA" id="MSHTLKC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="556"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="591"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="625"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="762"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="782" mass="85162" checksum="510FDC266D4781AA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV49</accession>
    <name>B8DV49_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA protection during starvation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0047</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Dps family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219320.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0047"/>
    <dbReference type="EnsemblBacteria" id="ACL28350">
        <property type="protein sequence ID" value="ACL28350"/>
        <property type="gene ID" value="BLA_0047"/>
    </dbReference>
    <dbReference type="GeneID" id="66532423"/>
    <dbReference type="KEGG" id="bla:BLA_0047"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.51"/>
    <dbReference type="HOGENOM" id="CLU_098183_1_0_11"/>
    <dbReference type="OMA" id="DDYSIGR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016722">
        <property type="term" value="F:oxidoreductase activity, acting on metal ions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01043">
        <property type="entry name" value="DPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002177">
        <property type="entry name" value="DPS_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023188">
        <property type="entry name" value="DPS_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42932">
        <property type="entry name" value="PTHR42932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005900">
        <property type="entry name" value="Dps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01346">
        <property type="entry name" value="HELNAPAPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00818">
        <property type="entry name" value="DPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin" evidence="3">
        <location>
            <begin position="21"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="160" mass="18276" checksum="7DF13AC55BE2680A" modified="2009-03-03" version="1">MALSFIIPGLDEVASEKIIGILQERLSQEQEAALVLKHAHWNVAGPNFIAVHEMLDPQVDEVLAMADETAERIAALGGSPSGRPDDIVRYRTWDKFELEGRQNTLDYLRALDKYYDSFIKADRTAIKELDDLDVISSNIVQDHVLKLEQFQWFMRSFLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV52</accession>
    <name>B8DV52_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_0050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219325.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0050"/>
    <dbReference type="EnsemblBacteria" id="ACL28353">
        <property type="protein sequence ID" value="ACL28353"/>
        <property type="gene ID" value="BLA_0050"/>
    </dbReference>
    <dbReference type="GeneID" id="66532426"/>
    <dbReference type="KEGG" id="bla:BLA_0050"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.54"/>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_11"/>
    <dbReference type="OMA" id="CVAVDFR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="371" mass="40358" checksum="1556A38700166DC3" modified="2009-03-03" version="1">MAGHRGAKRPSIFEVAKLAGVSHQTVSRVINHSPNVAEATRAKVEHAIAELGYHPSNSARSLASNRTRTVGMIAGGQRFYGPVSALASIEATARAHGMFVSVAMVHEAECTQQEFDDLCGMFMQQGVDAFIFLTPTDEMFKVACKSQVSQPCVIITSSHGGVSVSEGLHMFNARQRRRVSLVGIDQWAGMASVMRLIRKHGHRNVLFFAGPGQWRDASTRLMAWNKLCAQNTVNSVTVQCGDDWESADAYRRMNHILDNIGSNGGRLPTCAVCSNDVMAIGVIRALLEHGVRVPDDMSVTGFDDMPGMSNLYPPLTTVRQDFDDLGTMAMKEALFLMGEEAEPGYPNSQHGVGLVSADLIVRQSVRAAPRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV60</accession>
    <name>ARAA_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-arabinose isomerase</fullName>
            <ecNumber evidence="1">5.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">araA</name>
        <name type="ordered locus">BLA_0058</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of L-arabinose to L-ribulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-L-arabinopyranose = L-ribulose</text>
            <dbReference type="Rhea" id="RHEA:14821"/>
            <dbReference type="ChEBI" id="CHEBI:16880"/>
            <dbReference type="ChEBI" id="CHEBI:40886"/>
            <dbReference type="EC" id="5.3.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arabinose isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.4" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219339.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DV60"/>
    <dbReference type="SMR" id="B8DV60"/>
    <dbReference type="STRING" id="442563.BLA_0058"/>
    <dbReference type="EnsemblBacteria" id="ACL28361">
        <property type="protein sequence ID" value="ACL28361"/>
        <property type="gene ID" value="BLA_0058"/>
    </dbReference>
    <dbReference type="GeneID" id="66532434"/>
    <dbReference type="KEGG" id="bla:BLA_0058"/>
    <dbReference type="HOGENOM" id="CLU_045663_0_0_11"/>
    <dbReference type="OMA" id="HMLEICP"/>
    <dbReference type="UniPathway" id="UPA00145">
        <property type="reaction ID" value="UER00565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008733">
        <property type="term" value="F:L-arabinose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00519">
        <property type="entry name" value="Arabinose_Isome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024664">
        <property type="entry name" value="Ara_Isoase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038583">
        <property type="entry name" value="AraA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004216">
        <property type="entry name" value="Fuc/Ara_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003762">
        <property type="entry name" value="Lara_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38464">
        <property type="entry name" value="PTHR38464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11762">
        <property type="entry name" value="Arabinose_Iso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02610">
        <property type="entry name" value="Arabinose_Isome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001478">
        <property type="entry name" value="L-ara_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50443">
        <property type="entry name" value="SSF50443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0054">Arabinose catabolism</keyword>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000146224" description="L-arabinose isomerase">
        <location>
            <begin position="1"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00519"/>
        </source>
    </evidence>
    <sequence length="505" mass="55987" checksum="EF64A716269F520D" modified="2009-03-03" version="1">MAMENPFEGKEIWFGVGSQDLYGEEALRQVAQQSAEIVDSLNASGRIPVKLVLKPTLKSSDGVRRFMVDASADDSCIGVITWMHTFSPAKMWIRGLEALRKPLLQLNTQHHFEIPWETIDMDFMNLNQAAHGDREYGYIVTRLGIPRKIVVGHYTDPAVADKIGVWARACAGWQASNTMNVMRWGDNMRNVAVTEGDKTEAERVFGASINTWAVNELVAAYDAVKENQIKDLIEDYKAKYEIAPELLDKDYDSLFIAAREECAMVNMMRANGCTAGVDNFEDLGALPQLPGVGPQRFPSEYGWGFSAEGDWKTAVLVRIGAVMGYGLEGGASLMEDYSYNFTPGNEMIMGSHMLEVSPSVGTIAKPRLEIHPLGIGGKADPVRLVFTVAPKKDAVVVSLADVRTRFRMLMNVVDVVEPLGSLDKLPCARALWKPEPNLEISAECWLRAGGSHHTCMTTSVGREAWEDFARIAGVELAAIDAETTPREFERELEIEDVFHELANRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVA0</accession>
    <name>B8DVA0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AraJ-like protein probably involved in transport of arabinose polymers</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BLA_0098</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0098"/>
    <dbReference type="EnsemblBacteria" id="ACL28401">
        <property type="protein sequence ID" value="ACL28401"/>
        <property type="gene ID" value="BLA_0098"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0098"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.104"/>
    <dbReference type="HOGENOM" id="CLU_001265_61_2_11"/>
    <dbReference type="OMA" id="GSIVIHQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="13"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL28401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="408" mass="42517" checksum="9B797CCF28B062AA" modified="2009-03-03" version="1">MATRADRGGKQGRTGGNGLGLFALAAGAFVLGAAEFVMMGILPQTAQTLQVSIPTAGHFISAYAIGVCVGTLMLVFGRRIPPRTLIVMFMVIACAGNALSAMAVNAPMLVGARFLAGLPHGAFFGTATLVAKLLARKGKEARAVASMVTGQTVANMLGVPAGTLLAEHMSWRLAFVALAVCAAVTAVLARAWIPSVAPVRDAGLRGQFRFLRQPGPWMVLIAVFVGNTGIFCWWSYVSPWLQKVGGWPNNTISALMMLAGFGMVVGGLIGGRIADRWVPGGTSALGQCIACVGLLAVFLVPGSRWSTALFAFVISFALFFVSAPQQLLMAEAGKGGGELIGGATVQIAFNFGNAVGSMVGGGVLDASHMNYHYPALSGVPFAALAVLLLVLYSVRYERRGRDENPLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVC3</accession>
    <name>B8DVC3_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">crcB</name>
        <name evidence="11" type="ordered locus">BLA_0121</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218419.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0121"/>
    <dbReference type="TCDB" id="1.A.43.3.4">
        <property type="family name" value="the camphor resistance or fluoride exporter (fluc) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28424">
        <property type="protein sequence ID" value="ACL28424"/>
        <property type="gene ID" value="BLA_0121"/>
    </dbReference>
    <dbReference type="GeneID" id="66532496"/>
    <dbReference type="KEGG" id="bla:BLA_0121"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.127"/>
    <dbReference type="HOGENOM" id="CLU_079832_0_0_11"/>
    <dbReference type="OMA" id="VIAWFGT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL28424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="310" mass="33787" checksum="7BED2A6BDD89E58D" modified="2009-03-03" version="1">MTTRPEHLTHADATSPGDVDASSAAAEPGDSDAHLHLYDSQSFSPATGAPHEPVTPDFRKEMLQPHPTGAAAARRPPSIPLSPRKRMQAKFNPLADGMMYLVIFIGGMLGTVLRYSLWLLWPQPLSKGGLLMAFHPATLIANLCACFIFAVLVSYMSQAVWVKKRTRQLANGGFGMGMCGGFSTLSAMMVEDITSLHSHSYLGFFLYTLFTFVAAFAIAWFGSWLGLRLARKRTGMHVRERMETVRKPAIGVRVPTANGVQMTPSAGDDPNPSTDELPIISEEEHLDLLADPHMVEPLQRTAGKRDGGAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVE0</accession>
    <name>ILVC_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ketol-acid reductoisomerase (NADP(+))</fullName>
            <shortName evidence="1">KARI</shortName>
            <ecNumber evidence="1">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Acetohydroxy-acid isomeroreductase</fullName>
            <shortName evidence="1">AHIR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Ketol-acid reductoisomerase type 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Ketol-acid reductoisomerase type I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ilvC</name>
        <name type="ordered locus">BLA_0138</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218445.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DVE0"/>
    <dbReference type="SMR" id="B8DVE0"/>
    <dbReference type="STRING" id="442563.BLA_0138"/>
    <dbReference type="EnsemblBacteria" id="ACL28441">
        <property type="protein sequence ID" value="ACL28441"/>
        <property type="gene ID" value="BLA_0138"/>
    </dbReference>
    <dbReference type="GeneID" id="66532513"/>
    <dbReference type="KEGG" id="bla:BLA_0138"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.146"/>
    <dbReference type="HOGENOM" id="CLU_033821_0_1_11"/>
    <dbReference type="OMA" id="RAMFSWL"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000190910" description="Ketol-acid reductoisomerase (NADP(+))">
        <location>
            <begin position="1"/>
            <end position="350"/>
        </location>
    </feature>
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        <location>
            <begin position="3"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="3">
        <location>
            <begin position="184"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="26"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
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        <location>
            <begin position="84"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
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        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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        </ligand>
    </feature>
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        <location>
            <position position="228"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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        <location>
            <position position="232"/>
        </location>
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            <dbReference type="ChEBI" id="CHEBI:18420"/>
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        </ligand>
    </feature>
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        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <sequence length="350" mass="38583" checksum="BEAD33BB96DE7E31" modified="2009-03-03" version="1">MAAQIWYEDDGDLSVLDGKKVAIIGYGSQGHAHALNLRDSGVDVVVGLRPNSKSVEFAKEQGLEVKSVPEAAAEADVIMILAPDQYQKGIWENDIEPNIKPGAALAFAHGFNIHYGYIKPSEDHPVFMVAPKGPGHIVRREYVAGRGVPVVTAVEQDPRGDGWDLALAYAKALGALRAGAIKTTFKEETETDLFGEQNVLLGGVNKLVEMGFEVLTDAGYQPEIAYFEVCHELKMIVDLMNEGGLNKDRWSCSDTAQYGDYVSTVIDEHTRERMQYHLQRIQDGSFAKEFMDDQAAGAPKFKQLQEEYSNVRIEEVGPKLRAMFSWNNDAAKDADEANSFTGKIARAQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVE8</accession>
    <name>B8DVE8_BIFA0</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">BLA_0146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="ACL28449"/>
        <property type="gene ID" value="BLA_0146"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="53" mass="6027" checksum="F15C2CF2FF0CC475" modified="2009-03-03" version="1">MYDEGPHIVLRRDGVCIVAKTPDGDMPQIEYWGRDFAFDTAGDALRQLDMRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVI6</accession>
    <name>B8DVI6_BIFA0</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">BLA_0185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
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            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28487.1"/>
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    </dbReference>
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        <property type="protein sequence ID" value="ACL28487"/>
        <property type="gene ID" value="BLA_0185"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_131526_5_0_11"/>
    <dbReference type="OMA" id="NSAMPNF"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008769">
        <property type="entry name" value="PhaF_PhaI"/>
    </dbReference>
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        <property type="entry name" value="Phasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="99" mass="10510" checksum="024E156F33FF1AED" modified="2009-03-03" version="1">MPDFGEGLRKVFLAGVGAIAATAEKGQELVNDLVKRGELTVEQGKKLNSELAHKAGEKSDSLKEKLADASNTVRNAAAGLSDQAEQTIKKATEKKSDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVK0</accession>
    <name>B8DVK0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TadE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218516.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0199"/>
    <dbReference type="EnsemblBacteria" id="ACL28501">
        <property type="protein sequence ID" value="ACL28501"/>
        <property type="gene ID" value="BLA_0199"/>
    </dbReference>
    <dbReference type="GeneID" id="66532573"/>
    <dbReference type="KEGG" id="bla:BLA_0199"/>
    <dbReference type="HOGENOM" id="CLU_116311_3_0_11"/>
    <dbReference type="OMA" id="YVASHHN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="127" mass="13013" checksum="1D9F0A3DEE2E37ED" modified="2009-03-03" version="1">MGGHAFGQALRRLQCDDEGAATAEFAVVLPVIVMLAALMLYLGRASVVSVGCQDAAANAARALMVQGSGSGSQAMAQAAAGDGARIEVRPAGIGFEVIAHCAVVADPWGIVPRMVTGRAHGIWQERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVK1</accession>
    <name>B8DVK1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0200"/>
    <dbReference type="EnsemblBacteria" id="ACL28502">
        <property type="protein sequence ID" value="ACL28502"/>
        <property type="gene ID" value="BLA_0200"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0200"/>
    <dbReference type="HOGENOM" id="CLU_104210_2_1_11"/>
    <dbReference type="OMA" id="ASAYWSG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021202">
        <property type="entry name" value="Rv3654c-like"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03816">
        <property type="entry name" value="tadE_like_DECH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="157" mass="15872" checksum="BD71A058EE95E504" modified="2009-03-03" version="1">MGLRGSAPRRGMSAAARRVPTRSAPCIPHGLRAQDAGNASPSAVGIVLVVAVLLCTIAAGARIAMARAQARTAADMSALAAADAYWNEAAADPCGIGSAVARNNAGAVESCEVIDMDVAMEVSTATGVPFVERVSARARAGPRRCDEVDATRGASQP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVK3</accession>
    <name>RECR_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Recombination protein RecR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">recR</name>
        <name type="ordered locus">BLA_0202</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218519.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DVK3"/>
    <dbReference type="SMR" id="B8DVK3"/>
    <dbReference type="STRING" id="442563.BLA_0202"/>
    <dbReference type="EnsemblBacteria" id="ACL28504">
        <property type="protein sequence ID" value="ACL28504"/>
        <property type="gene ID" value="BLA_0202"/>
    </dbReference>
    <dbReference type="GeneID" id="66532576"/>
    <dbReference type="KEGG" id="bla:BLA_0202"/>
    <dbReference type="HOGENOM" id="CLU_060739_1_0_11"/>
    <dbReference type="OMA" id="DVMAIEN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01025">
        <property type="entry name" value="TOPRIM_recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00017">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000093">
        <property type="entry name" value="DNA_Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023628">
        <property type="entry name" value="Rcmb_RecR_C4-type_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015967">
        <property type="entry name" value="Rcmb_RecR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034137">
        <property type="entry name" value="TOPRIM_RecR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30446">
        <property type="entry name" value="PTHR30446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02132">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00615">
        <property type="entry name" value="recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01300">
        <property type="entry name" value="RECR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_1000195365" description="Recombination protein RecR">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Toprim" evidence="1">
        <location>
            <begin position="82"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00017"/>
        </source>
    </evidence>
    <sequence length="200" mass="21796" checksum="A72B3D7FEC452E96" modified="2009-03-03" version="1">MALAYDGAIQRLIDSFASLPGIGPKGAQRIAFYLLQAPDAESQRLVDAINEVKEKVRFCEVCGNVCESSPCTICSDPRRDHGTICVVEEPKDVMSIERTREYRGLYQVLGGAINPMANVGPSDLNIAQLLNRLHDGEVKEIIVALNPNIEGEATTTYLSRLLAPLDIKVTRLASGLPVGGDLEYADEITLSRALEGRREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVN2</accession>
    <name>B8DVN2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, AsnC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268308.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0231"/>
    <dbReference type="EnsemblBacteria" id="ACL28533">
        <property type="protein sequence ID" value="ACL28533"/>
        <property type="gene ID" value="BLA_0231"/>
    </dbReference>
    <dbReference type="GeneID" id="66532607"/>
    <dbReference type="KEGG" id="bla:BLA_0231"/>
    <dbReference type="HOGENOM" id="CLU_170329_3_0_11"/>
    <dbReference type="OMA" id="ETHIAFR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="6"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="92" mass="9588" checksum="45005BCF0C79472F" modified="2009-03-03" version="1">MADAIVLITTQADKVSEAAKKIVEIPGVKDVYSVAGDVDLVAIVSADDFDDLSTIIPDGIAKVPGVAGTQTLMAFRTYSREDDLAAFDLGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVN4</accession>
    <name>B8DVN4_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="7">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">murA</name>
        <name evidence="9" type="ordered locus">BLA_0233</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="7"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268315.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0233"/>
    <dbReference type="EnsemblBacteria" id="ACL28535">
        <property type="protein sequence ID" value="ACL28535"/>
        <property type="gene ID" value="BLA_0233"/>
    </dbReference>
    <dbReference type="GeneID" id="66532609"/>
    <dbReference type="KEGG" id="bla:BLA_0233"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.247"/>
    <dbReference type="HOGENOM" id="CLU_027387_0_0_11"/>
    <dbReference type="OMA" id="CRFGQRN"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="14"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate binding" evidence="7">
        <location>
            <begin position="28"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="2-(S-cysteinyl)pyruvic acid O-phosphothioketal" evidence="7">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL28535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="442" mass="47438" checksum="84ED3E1E25D0DB8D" modified="2009-03-03" version="1">MDVEKTDDVLHVVGGKPLNGTIKVRGAKNFVSKAMVAALLAPGTSVLKNVPEIRDVHVVSDLLRLHGVNVDVNGDEGIVTIDAKNVQLADVADVDTLSGSSRIPILFSGPLLHRLGEAFIPALGGCNIGGRPIDFHLETLRKLGATVDKEHKDGIHITAPNGLHGAKIHLPYPSVGATEQTLLAAVLADGKTELSGAATEPEIMDLVAVLQKMGAIISVDVDRTFRIEGVKELKGYTHTALTDRIEAASWASAALATHGDVFVKGATQPEMMTFLNVFRKIGGEFDITDRGIRFWHPGGDLKPVAIETDVHPGFMTDWQQPLVVALTQANGLSIVHETVYENRFGFTKPLVEMGATVQLYRECLGSLPCRFQQRNYKHSAVIFGPTPLEGRDIDVPDLRGGFSHLIAALAAKGPSDVRGISLIDRGYADFRGKLTALGAQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVR2</accession>
    <name>B8DVR2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP binding protein of ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_0261</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268375.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0261"/>
    <dbReference type="EnsemblBacteria" id="ACL28563">
        <property type="protein sequence ID" value="ACL28563"/>
        <property type="gene ID" value="BLA_0261"/>
    </dbReference>
    <dbReference type="GeneID" id="66532636"/>
    <dbReference type="KEGG" id="bla:BLA_0261"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.278"/>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_11"/>
    <dbReference type="OMA" id="CTHIADI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="404"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="626"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="682"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="633"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="438"/>
            <end position="445"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL28563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="733" mass="80839" checksum="B04BE3FBE87FC113" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVS4</accession>
    <name>B8DVS4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Permeases of the major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268393.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0273"/>
    <dbReference type="EnsemblBacteria" id="ACL28575">
        <property type="protein sequence ID" value="ACL28575"/>
        <property type="gene ID" value="BLA_0273"/>
    </dbReference>
    <dbReference type="GeneID" id="66532648"/>
    <dbReference type="KEGG" id="bla:BLA_0273"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.290"/>
    <dbReference type="HOGENOM" id="CLU_077680_3_1_11"/>
    <dbReference type="OMA" id="VAYCAFT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="206" mass="22467" checksum="80417CB026460C58" modified="2009-03-03" version="1">MRYLAGIWRLAIAALCFIGTSPAWHAVSLWAFLMYQIGFIAGIVMLWSGCASILRGVQPPALLRGFVLTYAFSLAAVHFFVTPAAEFGVPAQQVIPLSAQVLALIVVGMLAVDFFAFEPHRAFKPVYPLVWLVYLPLYAAFAIARAYWFPHSGPTANAYPYDYLIITQFTWGGAGVACLKIVAIYLAVGVVLCLFDRALPAKSAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVT6</accession>
    <name>B8DVT6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Predicted permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BLA_0285</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the auxin efflux carrier (TC 2.A.69) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268417.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0285"/>
    <dbReference type="EnsemblBacteria" id="ACL28587">
        <property type="protein sequence ID" value="ACL28587"/>
        <property type="gene ID" value="BLA_0285"/>
    </dbReference>
    <dbReference type="GeneID" id="66532662"/>
    <dbReference type="KEGG" id="bla:BLA_0285"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.303"/>
    <dbReference type="HOGENOM" id="CLU_056175_2_2_11"/>
    <dbReference type="OMA" id="TTFFWTL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="313" mass="33205" checksum="12471DFB2A860085" modified="2009-03-03" version="1">MGGLISAMEGFCVIGIVIAAGYAAARLQIGGAQAQYVFNRLSFFIASPCLMFAILAQENITHLFDSTIIVAFCSAVGVGLVFLVLNRLFFHLKAPDATIGVLNSLYLNSNNIGLPIATYILGNPALVAPILVMQQALFTPVGLTVLDVTTKGKFSVKQVLKQPLHQPLLIGTVLGIIVSVVSSKVGHFIVPNFLFDPIDMIGDSAVPMILMAFGMSLHGTKPMQNKSNLPAIWTVAALKNIVMPLIAFGIAFAMGFRGPTLYGCVVLAALPTGQNVYNYAARYNVGMTFARDGILISTMTSPIVIAIIAALLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVV9</accession>
    <name>B8DVV9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LemA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">lemA</name>
        <name evidence="7" type="ordered locus">BLA_0308</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LemA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268470.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0308"/>
    <dbReference type="EnsemblBacteria" id="ACL28610">
        <property type="protein sequence ID" value="ACL28610"/>
        <property type="gene ID" value="BLA_0308"/>
    </dbReference>
    <dbReference type="GeneID" id="66532687"/>
    <dbReference type="KEGG" id="bla:BLA_0308"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.330"/>
    <dbReference type="HOGENOM" id="CLU_056714_0_1_11"/>
    <dbReference type="OMA" id="VETQYQR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023353">
        <property type="entry name" value="LemA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007156">
        <property type="entry name" value="MamQ_LemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34478">
        <property type="entry name" value="PTHR34478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04011">
        <property type="entry name" value="LemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140478">
        <property type="entry name" value="SSF140478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL28610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="191" mass="21355" checksum="831ABF7DE81767C8" modified="2009-03-03" version="1">MSGWIIALIVIAIILVLTIWVIGMYNSLIGMRNRVGNSWAQVDVLLKQRADLIPNLVEVVKGYATHESTVFEQVTKARAGVVEVANNPNSTLEQRAAAEQALTNAMVNLRAIVEAYPDLKANQNFLDLQGRLASLEDKIAYGRQFYNDTVLKYNNRIMQVPTNIIAGMFHFQPAQYFAADEADRSVPQVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVW4</accession>
    <name>B8DVW4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaredoxin-like protein NrdH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nrdH</name>
        <name evidence="2" type="ordered locus">BLA_0313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268477.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0313"/>
    <dbReference type="EnsemblBacteria" id="ACL28615">
        <property type="protein sequence ID" value="ACL28615"/>
        <property type="gene ID" value="BLA_0313"/>
    </dbReference>
    <dbReference type="GeneID" id="66532692"/>
    <dbReference type="KEGG" id="bla:BLA_0313"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.335"/>
    <dbReference type="HOGENOM" id="CLU_026126_9_0_11"/>
    <dbReference type="OMA" id="PACVQCD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="87" mass="9572" checksum="5925B1A7CED947E8" modified="2009-03-03" version="1">MHITIYSKPNCPQCAATKRAFDRLGAPYTVVDITTDPVALATLQEAGFRQAPVVFVDSDFWTGYRPDRIRDVARRLQTVSSASGVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVW8</accession>
    <name>B8DVW8_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">4-diphosphocytidyl-2C-methyl-D-erythritol synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">MEP cytidylyltransferase</fullName>
            <shortName evidence="7">MCT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">ispD</name>
        <name evidence="8" type="ordered locus">BLA_0317</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="EC" id="2.7.7.60"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.60" evidence="7"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268485.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0317"/>
    <dbReference type="EnsemblBacteria" id="ACL28619">
        <property type="protein sequence ID" value="ACL28619"/>
        <property type="gene ID" value="BLA_0317"/>
    </dbReference>
    <dbReference type="GeneID" id="66532696"/>
    <dbReference type="KEGG" id="bla:BLA_0317"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.340"/>
    <dbReference type="HOGENOM" id="CLU_061281_2_1_11"/>
    <dbReference type="OMA" id="ERQHSVY"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050518">
        <property type="term" value="F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00108">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001228">
        <property type="entry name" value="IspD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018294">
        <property type="entry name" value="ISPD_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01295">
        <property type="entry name" value="ISPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5 7 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="7">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="7">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="275" mass="29596" checksum="F2FBE5FEEEEC34EC" modified="2009-03-03" version="1">MTQQTKVPVVAVVLAAGSGVRFDPAKPKQLVALNGKPIVAWSIEAFENDEHVDDIVVVVNNTVREAVEQLIDDASYAKVRAIITGGAERSDSTEAALTTLADAGIPQDAKILIHDAVRPFVSRQEIDGCIDALDEFTAATVACPSTDTILLTQDLGDREVIQSVPERRHSFRAQTPQAFRFGTIRDAYAKAAGDPDFRPTDDTRVVVDYLPDQPVAIVGGSPRNMKVTTQDDMPLARALANALAGAPRGPQNERQRAAKEQLHAMFGKAFGVEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVX7</accession>
    <name>B8DVX7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator of two-component system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_0326</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268504.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0326"/>
    <dbReference type="EnsemblBacteria" id="ACL28628">
        <property type="protein sequence ID" value="ACL28628"/>
        <property type="gene ID" value="BLA_0326"/>
    </dbReference>
    <dbReference type="GeneID" id="66532705"/>
    <dbReference type="KEGG" id="bla:BLA_0326"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.350"/>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_11"/>
    <dbReference type="OMA" id="IDRVWGS"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="132"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="132"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL28628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="235" mass="26629" checksum="7F7834331AC7B367" modified="2009-03-03" version="1">MTRILVVEDEPSYLDPLLYQLTREGYEAHGAATGEEAWELYEEMEFDLVLLDLMLPGISGTTLCRRMHELRRVPIIMVTAKSTENDVIVGLEIGADDYVTKPYSFRELLARIHAVLRRSLEPRASGTPGGNDETLTCGPIEMSVASHEVRIHGELTQFPLKEFEVLEYLMRNKGRVLTRQQLIGRVWGSDYVGDTKTLDVHVKRIRAKIEADPSNPALLTTVRGLGYRICDERSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVY8</accession>
    <name>B8DVY8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268522.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0337"/>
    <dbReference type="EnsemblBacteria" id="ACL28639">
        <property type="protein sequence ID" value="ACL28639"/>
        <property type="gene ID" value="BLA_0337"/>
    </dbReference>
    <dbReference type="GeneID" id="66532716"/>
    <dbReference type="KEGG" id="bla:BLA_0337"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.362"/>
    <dbReference type="HOGENOM" id="CLU_188172_0_0_11"/>
    <dbReference type="OMA" id="SELPPHW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="80" mass="9278" checksum="9EAEC8C367F0FB75" modified="2009-03-03" version="1">MTNKNEEPTSSHDAARPYSATRRTPRVHRRVVHQGTERFDADGVKPEPSEMQTAQQRQADDDKRILGELPPHWAVFEERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVZ1</accession>
    <name>B8DVZ1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="4">6.3.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="4"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0340"/>
    <dbReference type="EnsemblBacteria" id="ACL28642">
        <property type="protein sequence ID" value="ACL28642"/>
        <property type="gene ID" value="BLA_0340"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0340"/>
    <dbReference type="HOGENOM" id="CLU_066245_1_0_11"/>
    <dbReference type="OMA" id="VAVCWPW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="PTHR23407:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="5"/>
            <end position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="155"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="235" mass="25607" checksum="13B241B63D0DEE38" modified="2009-03-03" version="1">MAEAKRMLRHEVFVRRRGTSLSMSMQAGEQCAQIACEAGLFQSPSRIIACHVSMGTEISTIPLLSIALGCGYTVLVPKMGVDLDLGWGVLRSLDDLLRLHVPDEVAVDQMEPSLFPHAQTRRPGEPEGQTYPPEALQMCSTVIVPALLVNPAGVRLGRGAAWYDRALRFAGPQADLMAMCWPWEFVDAPLPCEEHDVRMNAVLTPRGFTRLGSTGPTRAHTDDPSCDSPAGEPDE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW17</accession>
    <name>RS19_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsS</name>
        <name type="ordered locus">BLA_0366</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268580.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DW17"/>
    <dbReference type="SMR" id="B8DW17"/>
    <dbReference type="STRING" id="442563.BLA_0366"/>
    <dbReference type="EnsemblBacteria" id="ACL28668">
        <property type="protein sequence ID" value="ACL28668"/>
        <property type="gene ID" value="BLA_0366"/>
    </dbReference>
    <dbReference type="GeneID" id="66532749"/>
    <dbReference type="KEGG" id="bla:BLA_0366"/>
    <dbReference type="HOGENOM" id="CLU_144911_0_1_11"/>
    <dbReference type="OMA" id="FPEMVGH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000146368" description="30S ribosomal protein S19">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <sequence length="92" mass="10522" checksum="A53377D6CCB11BC5" modified="2009-03-03" version="1">MTRSIKKGPFVDAHLQKKVDEQNAKGTHNVIKTWSRRSMITPDFIGHTFAVHDGRKHVPVFVTESMVGHKLGEFAPTRTFKGHVKDDKKSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWA5</accession>
    <name>B8DWA5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268771.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28756">
        <property type="protein sequence ID" value="ACL28756"/>
        <property type="gene ID" value="BLA_0457"/>
    </dbReference>
    <dbReference type="GeneID" id="66532840"/>
    <dbReference type="KEGG" id="bla:BLA_0457"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.486"/>
    <dbReference type="HOGENOM" id="CLU_1923488_0_0_11"/>
    <dbReference type="OMA" id="KHTARTH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="131" mass="14763" checksum="161D04382DDBD30C" modified="2009-03-03" version="1">MAEDKTSDELTERDIEDLNDPDDNPDVADADATEHNLRRAVIICFIVTSVMCLCINIVVLLMLQRKGKLDKAAANLDEFKENMQHLASDKSRQIARNKDVRKAMDTISQHIREIPSEAQSAVTRVRDSLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWC7</accession>
    <name>B8DWC7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polypeptide deformylase</fullName>
            <ecNumber evidence="3">3.5.1.88</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fms</name>
        <name evidence="3" type="ordered locus">BLA_0479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268808.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0479"/>
    <dbReference type="EnsemblBacteria" id="ACL28778">
        <property type="protein sequence ID" value="ACL28778"/>
        <property type="gene ID" value="BLA_0479"/>
    </dbReference>
    <dbReference type="GeneID" id="66532864"/>
    <dbReference type="KEGG" id="bla:BLA_0479"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.508"/>
    <dbReference type="HOGENOM" id="CLU_061901_3_1_11"/>
    <dbReference type="OMA" id="HEMDHFE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="142" mass="15679" checksum="5A5E429484687BB6" modified="2009-03-03" version="1">MQRTIVTDTSFLSRPSDPADPADPLDAAIAQDLKETLAAHREECVGMAANMIGEPKRVIAFVDEGLGSAITVMFNPQITAADGEYDACEGCLSLHGERHTPRFRRIEVDYTTRKGRARHATFTDWTAQIIQHEIDHCNGVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWC9</accession>
    <name>B8DWC9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268812.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0481"/>
    <dbReference type="EnsemblBacteria" id="ACL28780">
        <property type="protein sequence ID" value="ACL28780"/>
        <property type="gene ID" value="BLA_0481"/>
    </dbReference>
    <dbReference type="GeneID" id="66532866"/>
    <dbReference type="KEGG" id="bla:BLA_0481"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.510"/>
    <dbReference type="HOGENOM" id="CLU_089225_0_1_11"/>
    <dbReference type="OMA" id="FRMIGSI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017195">
        <property type="entry name" value="ABC_thiamin-permease_prd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09819">
        <property type="entry name" value="ABC_cobalt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037394">
        <property type="entry name" value="ABC_thiamine-permease_YkoE_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="210" mass="22402" checksum="CE3D31245583F944" modified="2009-03-03" version="1">MSTGITQSPRPSSSRFRWTPADIALGAALGVGCGLVFWGFNFAYTPISSVLGSILPGIASVLHAVWYFSGTLAVLILRKPGAAVYVNVVGSAVEMLLGNNFAFGFVFISAILQGVFAEIPFAATRYRVFNLPMAVLSGLCTALEYGFYLLFFRYQGVALLSPRGIVHMISELVGGALIAGVFSWLLFVAVAKTGALDHFASGRAVHVREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWF2</accession>
    <name>B8DWF2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Possible MarR-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218202.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0504"/>
    <dbReference type="EnsemblBacteria" id="ACL28803">
        <property type="protein sequence ID" value="ACL28803"/>
        <property type="gene ID" value="BLA_0504"/>
    </dbReference>
    <dbReference type="GeneID" id="66533635"/>
    <dbReference type="KEGG" id="bla:BLA_0504"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.534"/>
    <dbReference type="HOGENOM" id="CLU_083287_29_1_11"/>
    <dbReference type="OMA" id="NIDRAQH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="183" mass="20596" checksum="65EFE0599022B2C5" modified="2009-03-03" version="1">MDRVQGVNSPGMLRPSLEIKALHNLIGRYWNGIVPPDSMMSGANMPIVQYLHEHRDSDVFQYDIERAFSITRSTASRVLGLMEKKGLITRSAVDWDARVRKIELTPTASDLVVEIMRAAHQLETTLFTGFTPDEQERFMDDLARMRANLVETGLVGSERTAVEPATRTRQDATHQQQKGDEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWG4</accession>
    <name>B8DWG4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BLA_0516</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FldB/FldC dehydratase alpha/beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0516"/>
    <dbReference type="EnsemblBacteria" id="ACL28815">
        <property type="protein sequence ID" value="ACL28815"/>
        <property type="gene ID" value="BLA_0516"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0516"/>
    <dbReference type="HOGENOM" id="CLU_002393_1_0_11"/>
    <dbReference type="OMA" id="DNHFNCP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018709">
        <property type="entry name" value="CoA_activase_DUF2229"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008275">
        <property type="entry name" value="CoA_E_activase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010327">
        <property type="entry name" value="FldB/FldC_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09989">
        <property type="entry name" value="DUF2229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06050">
        <property type="entry name" value="HGD-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00241">
        <property type="entry name" value="CoA_E_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="5">
        <location>
            <begin position="21"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="BcrAD_BadFG" evidence="5">
        <location>
            <begin position="352"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2229" evidence="6">
        <location>
            <begin position="725"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1071"/>
            <end position="1093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL28815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="1555" mass="169735" checksum="966366CBCB3AA437" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWI0</accession>
    <name>B8DWI0_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanine aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Lysyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">pepN</name>
        <name evidence="16" type="ordered locus">BLA_0532</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218245.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0532"/>
    <dbReference type="MEROPS" id="M01.009"/>
    <dbReference type="EnsemblBacteria" id="ACL28831">
        <property type="protein sequence ID" value="ACL28831"/>
        <property type="gene ID" value="BLA_0532"/>
    </dbReference>
    <dbReference type="GeneID" id="66533662"/>
    <dbReference type="KEGG" id="bla:BLA_0532"/>
    <dbReference type="HOGENOM" id="CLU_007335_1_1_11"/>
    <dbReference type="OMA" id="CAYTNTG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012778">
        <property type="entry name" value="Pept_M1_aminopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02412">
        <property type="entry name" value="pepN_strep_liv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="15">
        <location>
            <begin position="22"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="13">
        <location>
            <begin position="247"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1_C" evidence="14">
        <location>
            <begin position="546"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ACL28831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="874" mass="97620" checksum="C50DE92F6175F9F4" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWJ1</accession>
    <name>B8DWJ1_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0543"/>
    <dbReference type="EnsemblBacteria" id="ACL28842">
        <property type="protein sequence ID" value="ACL28842"/>
        <property type="gene ID" value="BLA_0543"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0543"/>
    <dbReference type="HOGENOM" id="CLU_026152_4_1_11"/>
    <dbReference type="OMA" id="KLMVRQF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="DUF58" evidence="2">
        <location>
            <begin position="237"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="431" mass="46610" checksum="C400D1611E5E4CDD" modified="2009-03-03" version="1">MPPSPARASTVQCRRSSTTCRCRRRDSTKPTNPRMASADMAIRKYVSPLGWAVAGMFVLTLALFLCLGWVEMLAFALVCATLLVSSAALSVGNTAFTATLSVSNTRVSVNQTMHAMVTVSNPSTSVTASASGDLPISQSNYGSLEWHHERFAIPSLGAHQSKQTAIPLTATHRAVVTVGPLSVRKGDPFGLVRREHRLTEQIRVYIHPDIVPLHTLHAGIIRDLEGNPSDDLVNDDLSFFGLREYEYGDDVRNVHWLSTAKTGTLMIRQFEATRRTDSSVSLDVAAFSYASAEEFELAVSVFASIGVQCVSERRALYAQSGRLHVQPRKPADFLDTCSEIEPETRGGTMLANLAREALLACDKASLYCFVAGSAHEVDDLRRLGAAIPDSATCVVVQVVAGASSAVRTLPECVFITVGVLDDLPLLMEVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWR2</accession>
    <name>B8DWR2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translation initiation inhibitor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219194.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0620"/>
    <dbReference type="EnsemblBacteria" id="ACL28913">
        <property type="protein sequence ID" value="ACL28913"/>
        <property type="gene ID" value="BLA_0620"/>
    </dbReference>
    <dbReference type="GeneID" id="66533751"/>
    <dbReference type="KEGG" id="bla:BLA_0620"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.651"/>
    <dbReference type="HOGENOM" id="CLU_100715_7_3_11"/>
    <dbReference type="OMA" id="GSYFKEP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00004">
        <property type="entry name" value="TIGR00004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="132" mass="13764" checksum="DECE5D77CF1F20D0" modified="2009-03-03" version="1">MYENLQAVTTMEAPAALGAYSQAVKANGFVFVSGQLGIDPATGELDGVTAAEQAARALKNITNILAAAGCGVEHVCRATIYLRNVEDFSEVDGVYAKTFTGTVKPARVAFGNNMIPKGALVEIDVIAVCPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWR4</accession>
    <name>B8DWR4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative sugar transport integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_0622</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0622"/>
    <dbReference type="EnsemblBacteria" id="ACL28915">
        <property type="protein sequence ID" value="ACL28915"/>
        <property type="gene ID" value="BLA_0622"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0622"/>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_11"/>
    <dbReference type="OMA" id="IFSFYWK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="24"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL28915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="229" mass="24901" checksum="2464B3972E9DC102" modified="2009-03-03" version="1">MIPGTGLFRNIARAFGAMKFWEALGGTFLVATIVSISTVFFSTLAGYSFSKLRFRGRNALLMLVVATMTIPQQLSVVPLYIMANKAGLFGSLWAVIIPGLVSAFGVFWMTQYIGDALPYELIEAARVDGCSMFRTFLHVAIPAARPAAAMLFLFTFIAQWTNYFWPMLILGPNKNKMLTVAAATLKGAYFTDYTIVMSGVVLTTAPLLLLFFFAGKQLVSGIMAGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWR8</accession>
    <name>B8DWR8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Retinitis pigmentosa GTPase regulator-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0626</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0626"/>
    <dbReference type="EnsemblBacteria" id="ACL28919">
        <property type="protein sequence ID" value="ACL28919"/>
        <property type="gene ID" value="BLA_0626"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0626"/>
    <dbReference type="HOGENOM" id="CLU_054157_0_0_11"/>
    <dbReference type="OMA" id="LPDFAMP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867669" evidence="3">
        <location>
            <begin position="35"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="426" mass="45259" checksum="29A005B043BAA36A" modified="2009-03-03" version="1">MRGVVTPIFGLLAVACIVFGILNQTIWQPNPQIAATAPVRNTQYLLVDQGVANLVDKNVRIEAASPSATANDGVCMALTSPKDAAGWLAGQPYERITGLSNWSTLSYAEQGAQGEANTSGADVAFKDSNMWKEVNCGAGKASLDLKDAAGTDVVLADFGQKVSDGSLEMHWTRHDIPNFSIPWYFAGGLCAVLAVLCASVFAMDMSARRKKVSEDAERARQERQEQRKDEPKIGEALAGSLAALKPRSKGKSKTKGGPRHGRHAGKQEDEQPTTPTIVDPHARNLVAEQAQQANENASVEVSVANGSDEASETATRTVSNDGSATDGTTTSVITEAELQDYFARLAREVGMESSTPSEQGEPEAERVQDTDESESSEDEQSAESNESTESTEPEDVTETSEGGEASQEETEGEQSAAAESGDKEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWS1</accession>
    <name>B8DWS1_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP synthase epsilon chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP synthase F1 sector epsilon subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">F-ATPase epsilon subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">atpC</name>
        <name evidence="9" type="ordered locus">BLA_0629</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219181.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0629"/>
    <dbReference type="EnsemblBacteria" id="ACL28922">
        <property type="protein sequence ID" value="ACL28922"/>
        <property type="gene ID" value="BLA_0629"/>
    </dbReference>
    <dbReference type="GeneID" id="66533760"/>
    <dbReference type="KEGG" id="bla:BLA_0629"/>
    <dbReference type="HOGENOM" id="CLU_084338_4_0_11"/>
    <dbReference type="OMA" id="AADHFVW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="PTHR13822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0139">CF(1)</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_DE_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL28922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="102" mass="10549" checksum="08252F25F5F6CE47" modified="2009-03-03" version="1">MAGATIAVNIVSSERPVWSGEAKQVVVPAYAGGMGILPGHEPVLSVIEEGRLDVTDPNGKKFSFEVTGGFISFDSNKLTVAVENARSIAFQAEGADQSGIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWS8</accession>
    <name>B8DWS8_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">ATP synthase subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F0 sector subunit a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">atpB</name>
        <name evidence="13" type="ordered locus">BLA_0636</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cell membrane</location>
            <topology evidence="11 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the ATPase A chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219170.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0636"/>
    <dbReference type="EnsemblBacteria" id="ACL28929">
        <property type="protein sequence ID" value="ACL28929"/>
        <property type="gene ID" value="BLA_0636"/>
    </dbReference>
    <dbReference type="GeneID" id="66533767"/>
    <dbReference type="KEGG" id="bla:BLA_0636"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.667"/>
    <dbReference type="HOGENOM" id="CLU_041018_0_1_11"/>
    <dbReference type="OMA" id="FTHAVRL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045083">
        <property type="entry name" value="ATP_synth_F0_asu_bact/mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11410">
        <property type="entry name" value="PTHR11410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACL28929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="270" mass="30279" checksum="33ADF9FD0C8508BF" modified="2009-03-03" version="1">MVDVFSAGALTLAESSMEMPSIDDFLPPEILFQGTPFAINRIIFVRILATIIMLLVLGITAARAKLVPGRWQGAVEWLIEFIKKDIVYQVMGEVRGKRYVPMITTVFLTLLVFNLCGEVPGMNIAASATITLPLVFAMWCFAQYWIAGIREKGLGHFLRDELFPKGVPWPIYILLSPIQLLELLVIRPFSLTIRLFANMVSGHLILALCLSATQYFLIDVVNKFMMPFGVVTFAAGVFMYLFEVLVACLQAYIFAILTTAYINMSYPEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWT5</accession>
    <name>B8DWT5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RepB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">repB</name>
        <name evidence="3" type="ordered locus">BLA_0643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gram-positive plasmids replication protein type 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28936">
        <property type="protein sequence ID" value="ACL28936"/>
        <property type="gene ID" value="BLA_0643"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0643"/>
    <dbReference type="HOGENOM" id="CLU_1060345_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005727">
        <property type="term" value="C:extrachromosomal circular DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003916">
        <property type="term" value="F:DNA topoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002631">
        <property type="entry name" value="Plasmid_rep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01719">
        <property type="entry name" value="Rep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="262" mass="31129" checksum="1D7E6828DB915A49" modified="2009-03-03" version="1">MTDDNTQTSLNDKGRYWAGLIYPDSCPDDWKATMQMSGLQILVSPVHDKDIEDPKTGKLKKPHRHVVAMWTNTTTRRNATRFFEQFNGPKTILRVESPRGMARYLVHLDNPEKVQYLPEDVIEINGADWKKIALTDEERPEVMELLELIEEWEVHGYFELLKLCELKKPKLLPVAAKATTYCREVIWSYWQFKERNSKFKDELMERQREELRRKKATEQTKQRAQRKKLDQSARKSRKNRRVKNQPQKSAKKQRRKNHGHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWV1</accession>
    <name>B8DWV1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable solute binding protein of ABC transporter system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219131.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0659"/>
    <dbReference type="EnsemblBacteria" id="ACL28952">
        <property type="protein sequence ID" value="ACL28952"/>
        <property type="gene ID" value="BLA_0659"/>
    </dbReference>
    <dbReference type="GeneID" id="66533792"/>
    <dbReference type="KEGG" id="bla:BLA_0659"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.687"/>
    <dbReference type="HOGENOM" id="CLU_017028_7_3_11"/>
    <dbReference type="OMA" id="KNASLMW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="100"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="511" mass="55867" checksum="BB9F26F9E827D888" modified="2009-03-03" version="1">MTEHGNRRARKIRPWIVFFVIIAVLGAAAGVGITGLRGGNSGLNAVVGSLRGGRKLEVGLLDEPTSLDIRSNSERSVQQALMGNVYETLVTFNDEQAIASGLAARWTQTTDGLRYTFFLRNGLTFSDGTPLDASSVVRSLQQTLAGDHTNDGLSNITAVENNDARSVTFTLSSPNPRLLPALASQAGAIVNPNAKNPDFAHHSYGSGPFIVNAVQPGSIELTRNEHYWADKPKTSQATLRYYTDEQKMADDLKAGKLNVALPRSAHIAEQLSHTSGITLQDGFSTRKTLLALNSKSESPFSDEQVRQFTRYAIDARQIANAEPGAKAQLSGPISQMQPGYVDLDNLFQHDLGKASSMRWYFAADYFKPFNLLADEAHRELAQTLVDQIAAIPMPVSLEVVDSATLNSRVQSGDYTCALIEMDDPHDYTRFVDGSAMFGYVNGTVQQQYRKALEQTDFKDYREQLREFDRLVSDDAASAWLYTGKDYVAAQNDVQGVDANLAGSRLALAQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSJ3</accession>
    <name>B8DSJ3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Possible cell surface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0679</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219105.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0679"/>
    <dbReference type="EnsemblBacteria" id="ACL28972">
        <property type="protein sequence ID" value="ACL28972"/>
        <property type="gene ID" value="BLA_0679"/>
    </dbReference>
    <dbReference type="GeneID" id="66533812"/>
    <dbReference type="KEGG" id="bla:BLA_0679"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.708"/>
    <dbReference type="HOGENOM" id="CLU_028873_2_0_11"/>
    <dbReference type="OMA" id="FENGYAN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026466">
        <property type="entry name" value="Fim_isopep_form_D2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041033">
        <property type="entry name" value="Prealbumin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17802">
        <property type="entry name" value="SpaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04226">
        <property type="entry name" value="RrgB_K2N_iso_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870859" evidence="2">
        <location>
            <begin position="30"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="SpaA" evidence="3">
        <location>
            <begin position="393"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="560" mass="57734" checksum="75E812060BB4DE02" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSK2</accession>
    <name>B8DSK2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Possible membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0688"/>
    <dbReference type="EnsemblBacteria" id="ACL28981">
        <property type="protein sequence ID" value="ACL28981"/>
        <property type="gene ID" value="BLA_0688"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0688"/>
    <dbReference type="HOGENOM" id="CLU_176071_0_0_11"/>
    <dbReference type="OMA" id="IFRVYST"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="112" mass="12341" checksum="27E63C8C8545DD66" modified="2009-03-03" version="1">MQRQVEADKAKAAGLLNVYTTQLSSKKPGLQAAGRTWTYETILGQYRELKAKYPNALLVWGPDYTNYSRSGHPSDYYVMLSGETFATAQAAKGWCTANGYGSEDCLPVHLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSK5</accession>
    <name>B8DSK5_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ssb</name>
        <name evidence="6" type="ordered locus">BLA_0691</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219091.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0691"/>
    <dbReference type="EnsemblBacteria" id="ACL28984">
        <property type="protein sequence ID" value="ACL28984"/>
        <property type="gene ID" value="BLA_0691"/>
    </dbReference>
    <dbReference type="GeneID" id="66533824"/>
    <dbReference type="KEGG" id="bla:BLA_0691"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.720"/>
    <dbReference type="HOGENOM" id="CLU_078758_1_0_11"/>
    <dbReference type="OMA" id="GQMQERT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL28984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="210" mass="21544" checksum="63EF68E538750121" modified="2009-03-03" version="1">MAGETIITVVGNLTRDPELRTVGNGSTVVNFTIASSTRTFNRNTNQWDDGDTLFLNCSAWDSARTSMATNIANSLSKGMRVIAQGRLTQRSYQAQDGSQRSVVELRVDEIGPALSRATAQVTRQTSSGFNGGQQGGGYGNNGGGYQGGAGYSGGGFNGGNGGYQGGASAPAPQAPSAPVSDPWSNDSGSSNAFGSFGTSDFGGDSDEPEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSL8</accession>
    <name>B8DSL8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0704"/>
    <dbReference type="EnsemblBacteria" id="ACL28997">
        <property type="protein sequence ID" value="ACL28997"/>
        <property type="gene ID" value="BLA_0704"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0704"/>
    <dbReference type="HOGENOM" id="CLU_120898_0_0_11"/>
    <dbReference type="OMA" id="DHRHRKP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025329">
        <property type="entry name" value="DUF4235"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14019">
        <property type="entry name" value="DUF4235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="132" mass="14748" checksum="B1DA1A03DCE57F18" modified="2009-03-03" version="1">MQSAHTRDTNEKLANLDNTTKETVQRIDKVNNKITDLREQRMRDPDTLGDKAFKLAFPALIGMVAGKAFQSVWNLVTNKVHPSPNDDEADRKQGLLMSVLFAAASAAFSTVVTTYSDKLTQSIVGRLQRKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSP1</accession>
    <name>B8DSP1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218710.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0727"/>
    <dbReference type="EnsemblBacteria" id="ACL29020">
        <property type="protein sequence ID" value="ACL29020"/>
        <property type="gene ID" value="BLA_0727"/>
    </dbReference>
    <dbReference type="GeneID" id="66533488"/>
    <dbReference type="KEGG" id="bla:BLA_0727"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.758"/>
    <dbReference type="HOGENOM" id="CLU_176807_0_0_11"/>
    <dbReference type="OMA" id="PERSMTR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="83" mass="9291" checksum="4A14820B4A6348BE" modified="2009-03-03" version="1">MRLPERIPVGARVVVRITDGVDEYTGRHQYRDYVGHVRAWDGRTLQLTRDAAANGSRPAQDVDISATDIAILKPVPERPAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSQ7</accession>
    <name>B8DSQ7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldose 1-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0743"/>
    <dbReference type="EnsemblBacteria" id="ACL29036">
        <property type="protein sequence ID" value="ACL29036"/>
        <property type="gene ID" value="BLA_0743"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0743"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.774"/>
    <dbReference type="HOGENOM" id="CLU_052486_1_0_11"/>
    <dbReference type="OMA" id="NIDLIRP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09022">
        <property type="entry name" value="Aldose_epim_Ec_YihR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037480">
        <property type="entry name" value="YihR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="314" mass="34168" checksum="5281B66126AD9906" modified="2009-03-03" version="1">MSALPPRTGQQFSISHGDYTAVIAQLGATLRVFRYQGDDVTVSTGPDDVVTCCVGRVLVPFPNRLEHGSYDFDGAHYQLPINEPERDNAIHGFGMNYYWQLERLTEDSVTLSWRVPLTEGYPFSLQVFITYTLSNSGMRIDCDAVNNGDGPAPWAMAVHPWFSNGEDAHGNAIDAVTSRCSVQIPANTHVLTNGNLIPTGTEPVDGTKFDFRTAALLDRQPYDDALTDLTHAADGTVTAVFTRPDGRQVAIIGDESITSFQVCTGTGFPEAIHPTGVAVEPQTAYANTFRTGIDLIEIAPGDTAHTTIRYQVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSR2</accession>
    <name>B8DSR2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Folylpolyglutamate synthase</fullName>
            <ecNumber evidence="6">6.3.2.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">folC</name>
        <name evidence="6" type="ordered locus">BLA_0748</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="6"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0748"/>
    <dbReference type="EnsemblBacteria" id="ACL29041">
        <property type="protein sequence ID" value="ACL29041"/>
        <property type="gene ID" value="BLA_0748"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0748"/>
    <dbReference type="HOGENOM" id="CLU_015869_1_2_11"/>
    <dbReference type="OMA" id="YFEMGTL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="5">
        <location>
            <begin position="134"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="4">
        <location>
            <begin position="301"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="514" mass="56094" checksum="FDBBB48CF6B32115" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSR5</accession>
    <name>B8DSR5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0751</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29044">
        <property type="protein sequence ID" value="ACL29044"/>
        <property type="gene ID" value="BLA_0751"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0751"/>
    <dbReference type="HOGENOM" id="CLU_091254_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="180" mass="20096" checksum="B852FF87DCFAE3DC" modified="2009-03-03" version="1">MLQQHIVWNGTGVFFQDQKRDYLISNEHCKGYVKDRQEAFGTQWALVSVANDAGLTVGDQLTVFLESGAIETVNTTTSHIDHQHFHLPDSLGNDSYPLSRTLLTKGTGGFATVIAVPEDGRNRCKILVYKLYESDIQNLDSVYAIDTDGRLNEMLSGTTDYLSTDFAPNPRMHWKAPDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSS5</accession>
    <name>B8DSS5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218667.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29054">
        <property type="protein sequence ID" value="ACL29054"/>
        <property type="gene ID" value="BLA_0761"/>
    </dbReference>
    <dbReference type="GeneID" id="66533522"/>
    <dbReference type="KEGG" id="bla:BLA_0761"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.792"/>
    <dbReference type="HOGENOM" id="CLU_2614897_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="78" mass="8898" checksum="97BD63DCB01C1DC3" modified="2009-03-03" version="1">MTEQQITDNRHALVESLPPQFTREQLAAATNTTTTLWALKEDRHAGPKCTHTVNGQTWYARDDFAAWLYRQPATPDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSU1</accession>
    <name>B8DSU1_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13 14">UDP-N-acetylmuramoylalanine--D-glutamate ligase</fullName>
            <ecNumber evidence="5 13 14">6.3.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">D-glutamic acid-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 17" type="primary">murD</name>
        <name evidence="17" type="ordered locus">BLA_0778</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 14">
            <text>ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13 14">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.9" evidence="5 13 14"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218648.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0778"/>
    <dbReference type="EnsemblBacteria" id="ACL29070">
        <property type="protein sequence ID" value="ACL29070"/>
        <property type="gene ID" value="BLA_0778"/>
    </dbReference>
    <dbReference type="GeneID" id="66533540"/>
    <dbReference type="KEGG" id="bla:BLA_0778"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.811"/>
    <dbReference type="HOGENOM" id="CLU_032540_0_0_11"/>
    <dbReference type="OMA" id="CNFENYL"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008764">
        <property type="term" value="F:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00639">
        <property type="entry name" value="MurD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005762">
        <property type="entry name" value="MurD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01087">
        <property type="entry name" value="murD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13 14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 13 14" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 13 14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="12 13 14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13 14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="16">
        <location>
            <begin position="111"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="15">
        <location>
            <begin position="325"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="113"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ACL29070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="481" mass="50721" checksum="A8E0BE19375C32A9" modified="2009-03-03" version="1">MSNQEFNAAGKCVVVAGLGISGRSMAKILRDAGATVIGVDEKLEAADLHSFDDIDWDEVDLVCTSPVFNPRTPFIVEAQSRGIEVISEVELAWRMRVPSERTGSPAPWIGITGTNGKTSTTEMTSEMLKACGYTAPAVGNIGNALSAAALDPVNDVLCVELSSFQLHFTYSLELDCAAITNIAADHLDWHGGMANYATDKSKVFDGAKRVIAYNAQDARVSELARTAQTAEGCEHIGFTLGEPVSGQIGIKDGWIVDMSGLCGGQTGEAYALAPIADFTHLAEPDGTIYPHLLADALTALILVVGLGADVATALNALKRFAPGGHRIQTVAELASPEGTIRFVDDSKATNAHAARASLNSFAPGSVVWIAGGLSKGATFEELVEQERNRLKAVVVIGIDQKPMLEALKAKAPELPLTVIDPADNATVMERAIDAAADFAEPGDVVLLAPACASMDQFKSYADRGDQFAAQAKRWVNGHAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSW3</accession>
    <name>B8DSW3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218612.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0800"/>
    <dbReference type="EnsemblBacteria" id="ACL29092">
        <property type="protein sequence ID" value="ACL29092"/>
        <property type="gene ID" value="BLA_0800"/>
    </dbReference>
    <dbReference type="GeneID" id="66533562"/>
    <dbReference type="KEGG" id="bla:BLA_0800"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.833"/>
    <dbReference type="HOGENOM" id="CLU_093114_0_0_11"/>
    <dbReference type="OMA" id="MKVEQSA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="249" mass="26528" checksum="88570FB52869C702" modified="2009-03-03" version="1">MSDDDKRNPNNPDNPGDENDAFWAFESDPDLAREMESLNQELANLEQNASTDDAGESATGESEDGNAPEDVSDEFSQIMNANAEIGFDDELEGILGNKAKRAILVTRLTSADLLAAFCSLADITAQCIDSREGAVAVLRNLNGDGPEAAAKDLTEVVAGLSVLLLVDRADKMTAVPYANGTAEDAELPPPFVLETLAHFVEDLMLGLTTVDALAQQGVRIVDSADLDHDHALKIIAEHTNFGRDGSSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSW6</accession>
    <name>B8DSW6_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Histidinol dehydrogenase</fullName>
            <shortName evidence="10">HDH</shortName>
            <ecNumber evidence="5 10">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 17" type="primary">hisD</name>
        <name evidence="17" type="ordered locus">BLA_0803</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10 11 16">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="5 10"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619837.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0803"/>
    <dbReference type="EnsemblBacteria" id="ACL29095">
        <property type="protein sequence ID" value="ACL29095"/>
        <property type="gene ID" value="BLA_0803"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0803"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.836"/>
    <dbReference type="HOGENOM" id="CLU_006732_3_1_11"/>
    <dbReference type="OMA" id="MVTGPGN"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0520">NAD</keyword>
    <keyword evidence="9 10 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 15" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ACL29095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="466" mass="49717" checksum="44E158D51CBA1FEE" modified="2009-03-03" version="1">MSQDNYMRIIDLRGKELTRAEMLDAMPRAEMGTDEASEIVQPILDNVRENGAAALREYAEKFDHIVPKSFRVPTDVMDAAVACLDPEVRAAIEESVRRARAVAKSQVPEDFHTDLAEGARVSERWIPIQRVGLYVPGGKAVYPSSVIMNVVPAQAAGVESLAIATPPSRDNAQGWPNKTILATCAILGVDEVYAVGGAQAIAMFAYGATDLDNPVSPVLCEPVDKITGPGNIFVATAKRLVSGIVGIDAVAGPTEIAIIADKTSNPAYVAADLIGQAEHDELAGSVLITDDDQLAEAVQAELNKRVPRTEHSERVATSLSGKQSGIILTDGIEQSIDAANAYAAEHLEVQTADPDAVIAKIRNAGAIFRGNYSPVPLGDYMSGSNHVLPTSGTARFAAGLGVHTFMKPVEVIEYDEQGLKELAARVNALAVSEDLPAHGESVLTRFIDDPYNKETITEQEEEAGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSY9</accession>
    <name>B8DSY9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolases of the alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0826"/>
    <dbReference type="EnsemblBacteria" id="ACL29118">
        <property type="protein sequence ID" value="ACL29118"/>
        <property type="gene ID" value="BLA_0826"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0826"/>
    <dbReference type="HOGENOM" id="CLU_503295_0_0_11"/>
    <dbReference type="OMA" id="YWSWPVI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="430"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="558" mass="62028" checksum="CBCB47318006FB50" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT03</accession>
    <name>MURI_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamate racemase</fullName>
            <ecNumber evidence="1">5.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murI</name>
        <name type="ordered locus">BLA_0840</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Provides the (R)-glutamate required for cell wall biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamate = D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12813"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="EC" id="5.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.3" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218555.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DT03"/>
    <dbReference type="SMR" id="B8DT03"/>
    <dbReference type="STRING" id="442563.BLA_0840"/>
    <dbReference type="EnsemblBacteria" id="ACL29132">
        <property type="protein sequence ID" value="ACL29132"/>
        <property type="gene ID" value="BLA_0840"/>
    </dbReference>
    <dbReference type="GeneID" id="66533602"/>
    <dbReference type="KEGG" id="bla:BLA_0840"/>
    <dbReference type="HOGENOM" id="CLU_052344_1_0_11"/>
    <dbReference type="OMA" id="MPWGPRT"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008881">
        <property type="term" value="F:glutamate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00258">
        <property type="entry name" value="Glu_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018187">
        <property type="entry name" value="Asp/Glu_racemase_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004391">
        <property type="entry name" value="Glu_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF2">
        <property type="entry name" value="PTHR21198:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00067">
        <property type="entry name" value="glut_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00923">
        <property type="entry name" value="ASP_GLU_RACEMASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000125601" description="Glutamate racemase">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="43"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="188"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00258"/>
        </source>
    </evidence>
    <sequence length="258" mass="28801" checksum="27B4B90800E14D34" modified="2009-03-03" version="1">MTSSAPVGVFDSGLGGISVVRQIRTDLPHERILYFGDSANAPYGTKTPEQVRDLSFRIVEDFVEQGAKAVVIACNTATSSAVQELREHYDIPIIGMEPALKVACDRGHGERQSVIVAATPLTLRERKFAALMHRFEDAHTIHKQPCPRLVEIVERGELDDHDLVMRTLHDYFDQYDLAHTDSVVLGCTHFVFYRDYFRELLPNNVAIVDGNEGTARHLEVVLESLGKLAPEEQDGGVILRNSDPGERIAELAQQLLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT19</accession>
    <name>B8DT19_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619849.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0856"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29148">
        <property type="protein sequence ID" value="ACL29148"/>
        <property type="gene ID" value="BLA_0856"/>
    </dbReference>
    <dbReference type="GeneID" id="66533836"/>
    <dbReference type="KEGG" id="bla:BLA_0856"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.894"/>
    <dbReference type="HOGENOM" id="CLU_023845_2_1_11"/>
    <dbReference type="OMA" id="KVYYLVR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="326" mass="35989" checksum="DB0516C8FF01F14E" modified="2009-03-03" version="1">MQYSVTAVVVSYNRAGLLDECLSALNAQTRRPDSLVIVDNASTDGALQVARDFAGRTPIPAYILELRENTGGAGGFCAGIAYAVANGSAEPGIAEYVWLMDDDTVPTPTALEQLLAAADECVTVNDRLPTALGSKAVWVDGREHLMNKPRPRAVLAKGEREMAGGAYQVRSLSFVSCMLNMGAIRGRRRLPISAFFLWNDDFEYTTALLRNGVGYYVPASEVVHKTKKFGSSDADPGQRFYNEVRNKIWMLRFCRSDFSFGGLLSFLAKTARRWLLTVMRAGDRPLILQCLRDGWRDGWHTEPESNAEIFARACPPLVPDIERISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT28</accession>
    <name>B8DT28_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Leucine-rich repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269241.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0865"/>
    <dbReference type="EnsemblBacteria" id="ACL29157">
        <property type="protein sequence ID" value="ACL29157"/>
        <property type="gene ID" value="BLA_0865"/>
    </dbReference>
    <dbReference type="GeneID" id="66533843"/>
    <dbReference type="KEGG" id="bla:BLA_0865"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.903"/>
    <dbReference type="HOGENOM" id="CLU_1458594_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870473" evidence="1">
        <location>
            <begin position="28"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="185" mass="20427" checksum="2ADFB669690D1002" modified="2009-03-03" version="1">MNTLKKMAVSAVAALAGVMMVAPTAMAANGTIPIDAAHFPDTAFRVRIAQEFDSYPKDGKLTIAERNAVTEIRGGDSYEIKFAKGIGYFPTLENLYLYNQLLTSIDLSHNAKLQNLNLSRNKLTKIDLSRNPELRDLDLSSNKLISINVSKNTKLTEFDFQSNPLLWISSIAPAVNVDIYSPFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT47</accession>
    <name>B8DT47_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Probable permease protein of ABC transporter system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BLA_0884</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219294.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29176">
        <property type="protein sequence ID" value="ACL29176"/>
        <property type="gene ID" value="BLA_0884"/>
    </dbReference>
    <dbReference type="GeneID" id="66533863"/>
    <dbReference type="KEGG" id="bla:BLA_0884"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.924"/>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_11"/>
    <dbReference type="OMA" id="IYYWPLA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="33"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="348"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="383"/>
            <end position="390"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL29176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="598" mass="67240" checksum="C417EC0B021FD70C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT83</accession>
    <name>B8DT83_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase sensor of two-component system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217575.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0920"/>
    <dbReference type="EnsemblBacteria" id="ACL29212">
        <property type="protein sequence ID" value="ACL29212"/>
        <property type="gene ID" value="BLA_0920"/>
    </dbReference>
    <dbReference type="GeneID" id="66533466"/>
    <dbReference type="KEGG" id="bla:BLA_0920"/>
    <dbReference type="HOGENOM" id="CLU_000445_20_3_11"/>
    <dbReference type="OMA" id="ADANSHM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="191"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="388" mass="42248" checksum="246B61F3FE213C44" modified="2009-03-03" version="1">MIISVGAHALMFVVSVLFSVMLSGDTDTTFVIGLLFCVILCSLIRLAPLRCWIALAMMFCMVCLFVPQWIALMPIVGFDLGLRVQSLGRSFQMLVCVPPLVCGIVAGQHSPALHDLSAAATSPLVMALWILCALTSLAVLGGWVFALAQRRQRCFQSLADDQRERIRRSRARLADVESARSADLQHARLTERTRIAREIHDNVGHLLTRAIMLTNADQVIATSTGDTLHADQFGQLGHTLDEAMTMIRKSVHGLKDEGTDFRAMVEDAMATAKQSDVEIRLSNAIDAVPSHVAHAFTAVIRGALTNTIRHSAASEAHVHLIDLPGLWQLIVQGNGGVPERGRVASMGIGIADIEERARALDGTATCGYHNGGWRVFMSVPKTAERNMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT96</accession>
    <name>B8DT96_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0933"/>
    <dbReference type="EnsemblBacteria" id="ACL29225">
        <property type="protein sequence ID" value="ACL29225"/>
        <property type="gene ID" value="BLA_0933"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0933"/>
    <dbReference type="HOGENOM" id="CLU_179041_0_1_11"/>
    <dbReference type="OMA" id="MRLTVFW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021408">
        <property type="entry name" value="DUF3046"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11248">
        <property type="entry name" value="DUF3046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="79" mass="9038" checksum="0F459B0842A32417" modified="2009-03-03" version="1">MREREFWQLLEEVFGRSYGRALAHDQGLTKLHGMTVVEALAAGEEPRVVWNVLCGQMDVPDAKRWGRDHNAPPLPVDFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTD3</accession>
    <name>B8DTD3_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="2">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">clpP</name>
        <name evidence="4" type="ordered locus">BLA_0972</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0972"/>
    <dbReference type="MEROPS" id="S14.008"/>
    <dbReference type="EnsemblBacteria" id="ACL29262">
        <property type="protein sequence ID" value="ACL29262"/>
        <property type="gene ID" value="BLA_0972"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0972"/>
    <dbReference type="HOGENOM" id="CLU_058707_3_2_11"/>
    <dbReference type="OMA" id="RDYWMKA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="204" mass="22525" checksum="D80A5C57911F445E" modified="2009-03-03" version="1">MSDLITSPRMAGEDMPAGPADPIFNRLLKDRIIWLGEEVKDDMANRICAQMLMLAAEDPKSDIWLYINSPGGSITAGMAIYDTMQLIEPDVATVGIGMCASMGQFLLSSGTKGKRFLTSHARVLMHQPSGGIGGTTTDVRINAELIMDMKKTLGELTAEQTGHTIEEIYRDNEYDHWFTAEEALEYGFVDKLVSTHETMNSDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTI2</accession>
    <name>B8DTI2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Possible B-hexosaminidase</fullName>
            <ecNumber evidence="5">3.2.1.52</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_1021</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.52" evidence="5"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1021"/>
    <dbReference type="CAZy" id="GH3">
        <property type="family name" value="Glycoside Hydrolase Family 3"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29311">
        <property type="protein sequence ID" value="ACL29311"/>
        <property type="gene ID" value="BLA_1021"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1021"/>
    <dbReference type="HOGENOM" id="CLU_008392_0_1_11"/>
    <dbReference type="OMA" id="VKHYPGL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867593" evidence="3">
        <location>
            <begin position="29"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3" evidence="4">
        <location>
            <begin position="86"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="419" mass="43559" checksum="83CC445F2AA48DA7" modified="2009-03-03" version="1">MVRIVTTVIVTLAIVAIAIGAFAPVRHATDSDTTNGKAAPTSVPSRTSSPAPSTTISMPQTASPSPTPKTDGTSDRAKRIVEAMSLDERAGQLVMAALQYGNDPATLQAMIQEQHVGNVILMGNWVSGVENVARATQALQRLNASTGLPGLLIATDQEGGTVQHLSGPGFDAMPSATAQGQMPLDRLRAAARDWALPLKRSGLAMNLAPSVDTVTIERAVNEPIGALYRDFGLDAQRNGEHAAAFIEGMRAGGVGSAIKHYPGLGSVRGNTDFTANGIVDDTTTENGTEVNAFTSAIRQGKPAMVMVSLATYKLIDPDNPAAFSPAIVTDMLRRGTPFDGVVISDSLSAGAVSSIAPQDLGVRFIDAGGDICCMNAASYTQPILDGIRSRAAADKGFAAKVTASAERVVRLKIELGLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTI7</accession>
    <name>B8DTI7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein, family 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217713.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1028"/>
    <dbReference type="EnsemblBacteria" id="ACL29316">
        <property type="protein sequence ID" value="ACL29316"/>
        <property type="gene ID" value="BLA_1028"/>
    </dbReference>
    <dbReference type="GeneID" id="66533361"/>
    <dbReference type="KEGG" id="bla:BLA_1028"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1074"/>
    <dbReference type="HOGENOM" id="CLU_028871_2_2_11"/>
    <dbReference type="OMA" id="FIWDPVL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870875" evidence="1">
        <location>
            <begin position="32"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="66"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="321" mass="34315" checksum="84DC777355D4733F" modified="2009-03-03" version="1">MSRSTMLRFTSAACAALLSLSCSACGEPNAADSSTTMRVAYLSTANYLTTVRGEDFLDETMQHTNVKFTGPYNPTDAYSAVLSGNADATSTGTGSYINFVAQGQPWVAFAIEYYTGDSQGIVASPKSGVNSLEDLYGRNVAIIKRGGTGDYVLHKAFEHDGLDVGRVNIVEMSPSNFQAAFTSGQIDALSSFDQNLAAAMATPGAKLLVNATEYGNKNVSIHMVSKDFATKHPEAVKAMYRALVRESDVAQATPSIITDAYREFGASDDVTEQIARFNVPVIKPIDAEGLKMLESQAQEYVDFGFIDAMPDLQAASMDCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTR7</accession>
    <name>B8DTR7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Filamentation induced by cAMP protein Fic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fic</name>
        <name evidence="2" type="ordered locus">BLA_1108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1108"/>
    <dbReference type="EnsemblBacteria" id="ACL29396">
        <property type="protein sequence ID" value="ACL29396"/>
        <property type="gene ID" value="BLA_1108"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1108"/>
    <dbReference type="HOGENOM" id="CLU_1136323_0_0_11"/>
    <dbReference type="OMA" id="YPIVRAF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="PTHR13504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="120"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="271" mass="31223" checksum="5E44AF54A42BECDF" modified="2009-03-03" version="1">MPCVRGFRSRQMRDLCSCIDDWAYLATMEKQIEAWKELRRLDALMRRLGNRYPIVRAFSRLESKISCSLDGYDASLEDVLSYPERYIIERRRTVGSERAILNYLYTLGYGTVMVRGGQPLDWKFVRELHRQLCDGLTAAEPVLVAPRNMASGTMDDLFAWWDNNDISDSVIDDIIRFHYRFLALRPFAQGTGRMSRLLLLLQLIARGVLHEPILTMSIWLEGNIAEYRTCLDEAILRGNEQPLLMFFHDGFSDCAGAACNSVVSHSDSYRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTU1</accession>
    <name>B8DTU1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218854.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1132"/>
    <dbReference type="EnsemblBacteria" id="ACL29420">
        <property type="protein sequence ID" value="ACL29420"/>
        <property type="gene ID" value="BLA_1132"/>
    </dbReference>
    <dbReference type="GeneID" id="66532956"/>
    <dbReference type="KEGG" id="bla:BLA_1132"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1186"/>
    <dbReference type="HOGENOM" id="CLU_107924_1_0_11"/>
    <dbReference type="OMA" id="SAEDHYK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="223" mass="24936" checksum="86186421B621C2C5" modified="2009-03-03" version="1">MDGNNDAGRSIPAISKKWKIAGVVIAALSCMVVGCLLMLGFYSLFPGTMPAFLKEKVGTSDTQVIRSMERTKEVALLRLGITGIISQENKSHFFNMEIPGTERARFIQYTFDAKLGFEGKDVSIKETGKNTFDVEIPEFKFIGYDHPEYRMIVEQNGALSFGTQQIDSLDMINNILTEKTKQEYVDSNRDLLEEQAKSFYASIVMGVNPEAKLNFTFQTPKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTX2</accession>
    <name>B8DTX2_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoserine phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">serB</name>
        <name evidence="14" type="ordered locus">BLA_1163</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + O-phospho-D-serine = D-serine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24873"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58680"/>
            <dbReference type="EC" id="3.1.3.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-serine = L-serine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="3.1.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="6"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218899.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1163"/>
    <dbReference type="EnsemblBacteria" id="ACL29451">
        <property type="protein sequence ID" value="ACL29451"/>
        <property type="gene ID" value="BLA_1163"/>
    </dbReference>
    <dbReference type="GeneID" id="66532988"/>
    <dbReference type="KEGG" id="bla:BLA_1163"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1221"/>
    <dbReference type="HOGENOM" id="CLU_036368_4_3_11"/>
    <dbReference type="OMA" id="CINEPDL"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00029">
        <property type="entry name" value="phosphoserine_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACL29451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="233" mass="25271" checksum="2BB4EEF7D66A0096" modified="2009-03-03" version="1">MSAPLSQHLDNTDTLADPLPALGMPGLLVMDVDSTLIDEEVIDELGEEVGVGDEIAAITARAMNGELDFRQALDERVALLRGMPAQIFDRVYERLHFTNGAHELIDTLHAHGWKVGVVSGGFHEIVDRLAADAHLDYHIANRLGVDARRGMLTGEVVGDVVTKEVKLSRLRSWAQENDIARIQTVAVGDGANDLPMIGAAGLGIAFCAKPTVRTAAPHTIDERDLRKVLDFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTX3</accession>
    <name>B8DTX3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1164"/>
    <dbReference type="EnsemblBacteria" id="ACL29452">
        <property type="protein sequence ID" value="ACL29452"/>
        <property type="gene ID" value="BLA_1164"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1164"/>
    <dbReference type="HOGENOM" id="CLU_044208_1_1_11"/>
    <dbReference type="OMA" id="LFIYWIG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="267" mass="29304" checksum="07E08479C481D65B" modified="2009-03-03" version="1">MPRAGNGSASVSVLSRCCESGALMPLIVEKRWDNQSMHFTVTLAEAQLQCATSSDGLIGAMTAWLVSLMEHVGGVGVALAIALESIFPPIPSEIILPLAGFTAARGSMSLFGAILWATMGSLLGAWALYGIARWFGLHRIHKAVDRIPGVSRKDVNKANEWFNKYGTWSVLIGRVIPVVRSLISIPAGFNQMNFAKFSGWTFLGSAIWNTVLVTAGYMLGDQWCSILGVLNVFEDVIIVVFALMLVFFAWRWVRNLIRERRSTQSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTY3</accession>
    <name>B8DTY3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29462">
        <property type="protein sequence ID" value="ACL29462"/>
        <property type="gene ID" value="BLA_1174"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1174"/>
    <dbReference type="HOGENOM" id="CLU_2407353_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="97" mass="10216" checksum="CBF636BDDCB6632A" modified="2009-03-03" version="1">MCNGIMIGSNSAFNATSGTTTQCVCAGNAQECIALLVPLVRGSFHALDGLMAACRSDTGTWSGRAAELFHERLQAMEPRASACMQTLQMLDGLLSTM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTZ2</accession>
    <name>CH60_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chaperonin GroEL</fullName>
            <ecNumber evidence="1">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Chaperonin-60</fullName>
            <shortName evidence="1">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">groEL</name>
        <name evidence="1" type="synonym">groL</name>
        <name type="ordered locus">BLA_1183</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + a folded polypeptide = ADP + phosphate + an unfolded polypeptide.</text>
            <dbReference type="EC" id="5.6.1.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218937.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DTZ2"/>
    <dbReference type="SMR" id="B8DTZ2"/>
    <dbReference type="STRING" id="442563.BLA_1183"/>
    <dbReference type="PRIDE" id="B8DTZ2"/>
    <dbReference type="EnsemblBacteria" id="ACL29471">
        <property type="protein sequence ID" value="ACL29471"/>
        <property type="gene ID" value="BLA_1183"/>
    </dbReference>
    <dbReference type="GeneID" id="66533009"/>
    <dbReference type="KEGG" id="bla:BLA_1183"/>
    <dbReference type="HOGENOM" id="CLU_016503_3_0_11"/>
    <dbReference type="OMA" id="TDTDKME"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000147017" description="Chaperonin GroEL">
        <location>
            <begin position="1"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="477"/>
            <end position="479"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <sequence length="537" mass="56438" checksum="784D06124C05A9D3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU10</accession>
    <name>B8DU10_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Permease protein of ABC transporter for glutamate</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gluD</name>
        <name evidence="9" type="ordered locus">BLA_1201</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218142.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1201"/>
    <dbReference type="EnsemblBacteria" id="ACL29489">
        <property type="protein sequence ID" value="ACL29489"/>
        <property type="gene ID" value="BLA_1201"/>
    </dbReference>
    <dbReference type="GeneID" id="66533026"/>
    <dbReference type="KEGG" id="bla:BLA_1201"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1263"/>
    <dbReference type="HOGENOM" id="CLU_019602_1_3_11"/>
    <dbReference type="OMA" id="IGRGQWQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="76"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="348"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL29489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="363" mass="40407" checksum="2357736E5B4BAC50" modified="2009-03-03" version="1">MGNSDESSLLFDQPGPKGLKRIRIINWVATILFVVVLVLIVLRLHNPPDGENQLSWELWKPALDGEAWSDFYLPGLWATLRAAFLAVIGSVVFGLVFGIGRLLPSRIVQGICAIVIEFCRAVPVLIMMIFFWRAFAFLDLPSPSYWAVVISLVFYNGSVVAELIRSGVGNLPGGQHEAAVALGMTRTQSLMSIEVPQAIYAMLPAAVTQLVVVLKDTALGSIIMYTDLLQESRRLGSMYFNILQTLVVAAVIYFIICWLLSRLAEWLPVRMQQHTLAPTEPEPVAPIAIMDPSNVNQIAVAKEGRPLGGSQRLYHVHHRGTNARIHGWRRTRYVQGYDETQPQSQHVPAEHHMHHHSKGAGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU71</accession>
    <name>B8DU71_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">recN</name>
        <name evidence="9" type="ordered locus">BLA_1262</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">May be involved in recombinational repair of damaged DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the RecN family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619984.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1262"/>
    <dbReference type="EnsemblBacteria" id="ACL29550">
        <property type="protein sequence ID" value="ACL29550"/>
        <property type="gene ID" value="BLA_1262"/>
    </dbReference>
    <dbReference type="GeneID" id="66533084"/>
    <dbReference type="KEGG" id="bla:BLA_1262"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1325"/>
    <dbReference type="HOGENOM" id="CLU_018297_3_0_11"/>
    <dbReference type="OMA" id="QVICVTH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003128">
        <property type="entry name" value="RecN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00634">
        <property type="entry name" value="recN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="8">
        <location>
            <begin position="2"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR003128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL29550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="573" mass="62035" checksum="0C4E2DFD47238FAB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU73</accession>
    <name>B8DU73_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Threonine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">thrC</name>
        <name evidence="8" type="ordered locus">BLA_1264</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218056.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1264"/>
    <dbReference type="EnsemblBacteria" id="ACL29552">
        <property type="protein sequence ID" value="ACL29552"/>
        <property type="gene ID" value="BLA_1264"/>
    </dbReference>
    <dbReference type="GeneID" id="66533086"/>
    <dbReference type="KEGG" id="bla:BLA_1264"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1327"/>
    <dbReference type="HOGENOM" id="CLU_015170_3_1_11"/>
    <dbReference type="OMA" id="FGRIAFQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thr_synth_N" evidence="7">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="PALP" evidence="6">
        <location>
            <begin position="100"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="495" mass="54972" checksum="92C375AD770E4D80" modified="2009-03-03" version="1">MSTFHSTRSSDEAFTSKQAIRKGIADDGGLFVTDALGETKIDISDLAGKSYQQIALTVLSVLLDDYTEEELSQCIAEAYGSQWSDERITPVKPLGNDFIMELFNGPTCAFKDVALQILPRLMARTTPADGDCDEKIMIVTATSGDTGKAALAGFADAQGTGITVFYPQGKVSRVQELQMTTQQGSNVNVCAVDGNFDDAQSTVKRIFGDRDLASRLEADAHVRLSSANSINVGRLVPQVVYYFSAYAQLLEQQVINVGDQVDFVVPTGNFGNVLAGYYAKLLGLPVRQLVVASDRNNVLFDFLTTGTYNSKRPFFETTSPSMDILVSSNLERMLYYMSERDPRMITYLMNDLAEWGTYEVPPEMLMEIRKVFATGWADEDQVREMIADCWDRNHYVIDPHTACGYFVMQQMPADPQVPRVLLSTASPYKFPRVVNEALGLKADGTDFECMDELHAKSGTPIPQMLRNLENAEVRFRDCVEVSDMGHYVEECADRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU89</accession>
    <name>B8DU89_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_1281</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1281"/>
    <dbReference type="EnsemblBacteria" id="ACL29568">
        <property type="protein sequence ID" value="ACL29568"/>
        <property type="gene ID" value="BLA_1281"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1281"/>
    <dbReference type="HOGENOM" id="CLU_087829_1_1_11"/>
    <dbReference type="OMA" id="SVIVVEW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00150">
        <property type="entry name" value="T6A_YjeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="203" mass="21602" checksum="94B7461594FEE8E4" modified="2009-03-03" version="1">MLEPNPSPAPRQPDSTITLQVPTAQAMHELGERLARSLHGGEVILLSGPLGAGKTTLAQGLGEGLGIQEPIVSPTFTIARELDGTLADGTPAHLIHVDAYRLGSNDYAPGQAQADLLLDELESLGLDEELEEPGTRTIILMEWGEQMAVALADERLEIRIQRPTDHVSAPIGRNEPTADGERIVTITPVGTRFALAEPADTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU95</accession>
    <name>B8DU95_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218027.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29574">
        <property type="protein sequence ID" value="ACL29574"/>
        <property type="gene ID" value="BLA_1287"/>
    </dbReference>
    <dbReference type="GeneID" id="66533113"/>
    <dbReference type="KEGG" id="bla:BLA_1287"/>
    <dbReference type="HOGENOM" id="CLU_1988284_0_0_11"/>
    <dbReference type="OMA" id="MEGMSDN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="125" mass="14197" checksum="5A59A0A7F57842B5" modified="2009-03-03" version="1">MSRNTDDRRALAAIESERMEDQIAYYRKPFMVLWAAVQEASSELEEDYGLSSDVSQLWVAERLRQVSDSLVDRLAEKAVQHGTSKSNVARAADSDPTNAMRRFPRLRPGAVRTRLLIDEVLDSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUC6</accession>
    <name>B8DUC6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sbp family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217983.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1318"/>
    <dbReference type="EnsemblBacteria" id="ACL29605">
        <property type="protein sequence ID" value="ACL29605"/>
        <property type="gene ID" value="BLA_1318"/>
    </dbReference>
    <dbReference type="GeneID" id="66533143"/>
    <dbReference type="KEGG" id="bla:BLA_1318"/>
    <dbReference type="HOGENOM" id="CLU_135532_0_0_11"/>
    <dbReference type="OMA" id="TGFFFNI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009709">
        <property type="entry name" value="DUF1290"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06947">
        <property type="entry name" value="DUF1290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018579">
        <property type="entry name" value="Sbp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR018579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="110" mass="11795" checksum="6B443D2CB14269DE" modified="2009-03-03" version="1">MAAVLGLIIGVVVGLFVKPDIPIWLQPYLPIMVVAALDALLGAARAYFERSFSDKVFVISFFSNVVTATLLVLLGNQLGVGSQLSTAVIVVLGIRIFSNVSAIRRFIFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUF1</accession>
    <name>B8DUF1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_1345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1345"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29630">
        <property type="protein sequence ID" value="ACL29630"/>
        <property type="gene ID" value="BLA_1345"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1345"/>
    <dbReference type="HOGENOM" id="CLU_009583_2_1_11"/>
    <dbReference type="OMA" id="VCPYSWD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="28"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="389" mass="43192" checksum="8C1888C37633B7C3" modified="2009-03-03" version="1">MHTKSGTAGQQNALRVGIICPYSFETPGGVQNHIRDFARQLRRRGHEVQVFAPGRRTADMPQYVHTNNSSFAIPYNGSWAHLSYFLNAGHTTRKWVRDGGFDILHLHEPETPSLSHKPLVMHDAPPMVATFHASIEPYPRALRLFTRYLRKYLSPLREAIFVSESAQKTAEHYLPQQVGVQTIPNGIECDFYRRAEPNPQWQGSPEAPTIGFLGRMGEERKGFTVFAQAAKIVHEAFPSARFLVAGDGQEDGGKTLDAIGADKGLRERFEFLGRVSDADKARFYRSLSMYVAPQTGGESFGIVLAEAMAAGCPVIASDLDAFRAVTEEGSSAALFVNRDANDCARRMTELIEDPARRQSLSQAGSIRSRSFDWNTVVDEVLEVYAKALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUG3</accession>
    <name>B8DUG3_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transketolase</fullName>
            <ecNumber evidence="5">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">tkt</name>
        <name evidence="11" type="ordered locus">BLA_1357</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217933.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1357"/>
    <dbReference type="EnsemblBacteria" id="ACL29642">
        <property type="protein sequence ID" value="ACL29642"/>
        <property type="gene ID" value="BLA_1357"/>
    </dbReference>
    <dbReference type="GeneID" id="66533188"/>
    <dbReference type="KEGG" id="bla:BLA_1357"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1420"/>
    <dbReference type="HOGENOM" id="CLU_009227_0_0_11"/>
    <dbReference type="OMA" id="HHTEGIE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="PTHR43522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="10">
        <location>
            <begin position="373"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL29642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="698" mass="76360" checksum="C1B8CBAABB58448F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUG4</accession>
    <name>B8DUG4_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Transaldolase</fullName>
            <ecNumber evidence="6 7">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">tal</name>
        <name evidence="8" type="ordered locus">BLA_1358</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 7">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the transaldolase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="6 7"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217932.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1358"/>
    <dbReference type="EnsemblBacteria" id="ACL29643">
        <property type="protein sequence ID" value="ACL29643"/>
        <property type="gene ID" value="BLA_1358"/>
    </dbReference>
    <dbReference type="GeneID" id="66533189"/>
    <dbReference type="KEGG" id="bla:BLA_1358"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1421"/>
    <dbReference type="HOGENOM" id="CLU_050771_1_0_11"/>
    <dbReference type="OMA" id="ATECYYQ"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00955">
        <property type="entry name" value="Transaldolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00493">
        <property type="entry name" value="Transaldolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004732">
        <property type="entry name" value="Transaldolase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036915">
        <property type="entry name" value="Trnald_Bac_Plnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00876">
        <property type="entry name" value="tal_mycobact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0704">Schiff base</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="7">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="368" mass="39862" checksum="B70B8C4A3088E7FC" modified="2009-03-03" version="1">MTASTQAISDAGVSIWLDDLSRTRIESGNLEELIKNDNVVGVTTNPSIFQKALSQVGPYDAQLKELGKVDVETAIRELTTTDVRNACDIFKPVAEASDYVNGRVSIEVDPRLAHETAETEKQAEELWAKVDRPNAMIKIPATLEGLPAITATLAKGISVNVTLIFSLERYEQVIDAFIEGMVQADANGKDLSKMASVASFFVSRVDTAVDKKLEEIGSLEAKGLEGKAAVANARLAYELFEKKFAEDPRWAALEAKGAKKQRPLWASTGTKNAAYSDVKYVDELVAKDVVNTMPEKTLLAVADHGQATLGIIPGNYDEAHDIMNDLAEVGINFKDVTDKLEADGVAAFIKSWDSVLTDVQSGIDRVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUG6</accession>
    <name>B8DUG6_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217930.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1360"/>
    <dbReference type="EnsemblBacteria" id="ACL29645">
        <property type="protein sequence ID" value="ACL29645"/>
        <property type="gene ID" value="BLA_1360"/>
    </dbReference>
    <dbReference type="GeneID" id="66533191"/>
    <dbReference type="KEGG" id="bla:BLA_1360"/>
    <dbReference type="HOGENOM" id="CLU_017584_4_3_11"/>
    <dbReference type="OMA" id="SQGANQY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="28"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="399" mass="44242" checksum="69FC8161A60E9156" modified="2009-03-03" version="1">MKPINQTIAHLKPSGIRKYFDLANSMEGVISLGVGEPDFDTPWHISAKAVESFEDGHTHYTANRGLIALRKQIAGYYHSRYGIDYDPQSEILVTVGGSEAVDLCCRTLISPGDEVIVLDPNYVAYEPAILMAGGVPVRIELTQDNDFKLLPEDLERAINDHTKAIILNFPSNPTGGVMTREDYERVVPILKESGIYVISDEIYSELLFEGEFCSPANFEQIRDQVLVINGFSKAFAMTGWRLGYLLSNADLSQQLTKVHQFVIMSAPTSAQYAAIEALEHGIADTESMRREYESRRNLICARLNRMGLTTNVPKGTFYVFTNITSSGLTSDEFCVRLLEEHKVAIVPGTAFGDSGEGFVRISYATSMENIKEACSRIEAFLESLHLPSESVDSHHGSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUH6</accession>
    <name>B8DUH6_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UvrABC system protein C</fullName>
            <shortName evidence="6">Protein UvrC</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Excinuclease ABC subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">uvrC</name>
        <name evidence="11" type="ordered locus">BLA_1370</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with UvrB in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UvrC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1370"/>
    <dbReference type="EnsemblBacteria" id="ACL29655">
        <property type="protein sequence ID" value="ACL29655"/>
        <property type="gene ID" value="BLA_1370"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1370"/>
    <dbReference type="HOGENOM" id="CLU_014841_3_2_11"/>
    <dbReference type="OMA" id="HIECFDN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00203">
        <property type="entry name" value="UvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 6" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="GIY-YIG" evidence="9">
        <location>
            <begin position="25"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="8">
        <location>
            <begin position="218"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="UVRC" evidence="10">
        <location>
            <begin position="269"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="376"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="571"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL29655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="759" mass="84853" checksum="550707D53729C64D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUI2</accession>
    <name>B8DUI2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP binding protein of ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_1376</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217912.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1376"/>
    <dbReference type="EnsemblBacteria" id="ACL29661">
        <property type="protein sequence ID" value="ACL29661"/>
        <property type="gene ID" value="BLA_1376"/>
    </dbReference>
    <dbReference type="GeneID" id="66533206"/>
    <dbReference type="KEGG" id="bla:BLA_1376"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1440"/>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_11"/>
    <dbReference type="OMA" id="AQADKMR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="327"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="359"/>
            <end position="366"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="533" mass="58648" checksum="E816DEEC3C4B028E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUK9</accession>
    <name>B8DUK9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable ATP binding protein of ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_1403</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269094.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1403"/>
    <dbReference type="EnsemblBacteria" id="ACL29688">
        <property type="protein sequence ID" value="ACL29688"/>
        <property type="gene ID" value="BLA_1403"/>
    </dbReference>
    <dbReference type="GeneID" id="66533232"/>
    <dbReference type="KEGG" id="bla:BLA_1403"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1467"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_11"/>
    <dbReference type="OMA" id="HVLMIRQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="11"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="280" mass="31125" checksum="8E2FD0634EF24204" modified="2009-03-03" version="1">MEGLDCETRALAMHNVHLRRYGRVIVDDVNLEIGRGEKWILFGPNGIGKSSLISMMSTRAFPTSGDIDVLGRRLGKVDVFSYRHLIGLSSAELSRAFPPFEDPLDVVVTALSATTGRWKDTYTSDEYARARRLMEDFGIAYLAGKQFGRLSEGERTRTLICRALMAQSELLILDEPTTGLDLGAREITIRALSSLHDDPRTIIVVTHHLEEIPQGFDHIAIMGRQSTVTSQPDPADPAPGTIEYAGDLEHGLTAERLSRLFGMPLDVHHIDDRWSAFARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUL4</accession>
    <name>B8DUL4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glutamate synthase (NADPH) large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">gltB</name>
        <name evidence="16" type="ordered locus">BLA_1408</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AD011</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutamate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1408"/>
    <dbReference type="MEROPS" id="C44.003"/>
    <dbReference type="EnsemblBacteria" id="ACL29693">
        <property type="protein sequence ID" value="ACL29693"/>
        <property type="gene ID" value="BLA_1408"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1408"/>
    <dbReference type="HOGENOM" id="CLU_000422_8_2_11"/>
    <dbReference type="OMA" id="RVMGPEQ"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015930">
        <property type="term" value="F:glutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="SSF69336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="15">
        <location>
            <begin position="27"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ACL29693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="1522" mass="166791" checksum="19D27514963576BC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUM6</accession>
    <name>B8DUM6_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GTPase Era</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 12" type="primary">era</name>
        <name evidence="12" type="ordered locus">BLA_1420</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217854.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1420"/>
    <dbReference type="EnsemblBacteria" id="ACL29705">
        <property type="protein sequence ID" value="ACL29705"/>
        <property type="gene ID" value="BLA_1420"/>
    </dbReference>
    <dbReference type="GeneID" id="66533249"/>
    <dbReference type="KEGG" id="bla:BLA_1420"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1484"/>
    <dbReference type="HOGENOM" id="CLU_038009_0_2_11"/>
    <dbReference type="OMA" id="WAEVDVI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00436">
        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Era-type G" evidence="11">
        <location>
            <begin position="20"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="10">
        <location>
            <begin position="230"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="8">
        <location>
            <begin position="28"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="8">
        <location>
            <begin position="54"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="8">
        <location>
            <begin position="75"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="8">
        <location>
            <begin position="149"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="8">
        <location>
            <begin position="178"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="28"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="75"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="149"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACL29705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="331" mass="36808" checksum="EEE82EB443E01427" modified="2009-03-03" version="1">MADQTHTKGVDAVSGVTPYRSGFVAVVGRPNVGKSTLINALIGMQIAIASSRPETTRKAIRGVLTTDNAQIVLVDTPGIHRPRTLLGQRLNDVVDESLADSDEIAFLLPADQEIGPGDRRILSRLRSQFATKNDDGTFKWKVPLIAIVTKIDRLNRTELVNKLIEINEFADFADIVPVSALGDDNLQEVRTVLIEHLPEGPQMYPTDQVTEERPEDAIAELVRGVLLEELDDELPHSLAVVVDSIDMPEDMDEDDAQAMHGKARVMVSIYVERDSQKPIIIGRHAEHLVRIKKRLRTPVNRLVGRKANLDLHVKVAKNWQSDPKKLDRLGF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUQ4</accession>
    <name>AROC_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chorismate synthase</fullName>
            <shortName evidence="1">CS</shortName>
            <ecNumber evidence="1">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aroC</name>
        <name type="ordered locus">BLA_1449</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="1">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the chorismate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217819.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DUQ4"/>
    <dbReference type="SMR" id="B8DUQ4"/>
    <dbReference type="STRING" id="442563.BLA_1449"/>
    <dbReference type="EnsemblBacteria" id="ACL29733">
        <property type="protein sequence ID" value="ACL29733"/>
        <property type="gene ID" value="BLA_1449"/>
    </dbReference>
    <dbReference type="GeneID" id="66533279"/>
    <dbReference type="KEGG" id="bla:BLA_1449"/>
    <dbReference type="HOGENOM" id="CLU_034547_2_0_11"/>
    <dbReference type="OMA" id="MLSINAV"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000132754" description="Chorismate synthase">
        <location>
            <begin position="1"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="134"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="257"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="317"/>
            <end position="321"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <sequence length="396" mass="42181" checksum="0AD4C00080EA3927" modified="2009-03-03" version="1">MLRWQTAGESHGEALVAMIEGMPSGVRVTSQDIRDALARRRLGYGRGARMKFEQDQVRLLTGVRFGSTLGSPIAIEIGNTEWPKWTEVMSADPLDHELAREGRNAPLSRPRPGHADLTGMRKYGFDDARPVLERSSARETASRVALGEVAALFLEQVAGIRTVSHVISIGGAGVESDNTPLPGPDDVAALDASPVRTLDKDAEERMVARIDEAKAKADTLGGVIEVIAYGVPAGIGTYVESDRRLDAALAAAVMGIQAIKGVEIGDGFLEAGRPGSMAHDEMVPGDDGCIARLSNRAGGIEGGMSNGQPIRVRAAMKPIPSIPRALRTVDITTGEAAQAINQRSDSTAVPAAAVVAEAMVRLTLAQHLLEKFGGDSIEETRRNIEGYLASWPEHMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUX3</accession>
    <name>B8DUX3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar permease of ABC transporter system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">msmG</name>
        <name evidence="7" type="ordered locus">BLA_1520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1520"/>
    <dbReference type="EnsemblBacteria" id="ACL29802">
        <property type="protein sequence ID" value="ACL29802"/>
        <property type="gene ID" value="BLA_1520"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1520"/>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_11"/>
    <dbReference type="OMA" id="FMRNFIA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
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    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="96"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="301" mass="33357" checksum="AFBE9B9BE09A44EC" modified="2009-03-03" version="1">MTTATANTMSQQSAQQSATMNTAPAKAEKFRKDRRINWWLTAVVAVFSLTILVPLYFTVVTALKTPAEAGTFSLPTSWQWGNFAAASAKVDYPRAALNSAIITVLAVSLTLVTNTFVAYAIARNMDKRFFRFLYYFFIAAMFVPFPVVMLPLAKQMGSWHLDNQAGLIVLYVILGLGTNLFIATGFIRSIPVSLEEAARIDGAGTWRIFWKIIFPLMGPINATIAIMTALWAWNDFLLPLIILTDQSNQTIPLAQYVFSSQFATNYPQAFASYLMAMAPVLVVYIFAQKWVVGGVMRGAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUY3</accession>
    <name>B8DUY3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cation-transporting ATPase PacL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">pacL1</name>
        <name evidence="12" type="ordered locus">BLA_1530</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1530"/>
    <dbReference type="EnsemblBacteria" id="ACL29812">
        <property type="protein sequence ID" value="ACL29812"/>
        <property type="gene ID" value="BLA_1530"/>
    </dbReference>
    <dbReference type="GeneID" id="66533927"/>
    <dbReference type="KEGG" id="bla:BLA_1530"/>
    <dbReference type="HOGENOM" id="CLU_002360_3_3_11"/>
    <dbReference type="OMA" id="GVHRMAK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
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        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="769"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="813"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="852"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="902"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="934"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="966"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="11">
        <location>
            <begin position="39"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACL29812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="996" mass="106349" checksum="5CD264F6364FE587" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUY4</accession>
    <name>B8DUY4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA/rRNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218981.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1531"/>
    <dbReference type="EnsemblBacteria" id="ACL29813">
        <property type="protein sequence ID" value="ACL29813"/>
        <property type="gene ID" value="BLA_1531"/>
    </dbReference>
    <dbReference type="GeneID" id="66533928"/>
    <dbReference type="KEGG" id="bla:BLA_1531"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1606"/>
    <dbReference type="HOGENOM" id="CLU_021322_0_0_11"/>
    <dbReference type="OMA" id="QVPPYEY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="2">
        <location>
            <begin position="69"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="331" mass="35367" checksum="832537AB235CC6A3" modified="2009-03-03" version="1">MATKKGPTKGSGGKHRNSLRGKGPTPKAEDRVYHKAYKAKKQAEKRQRSDPRLAARRRAAHFTSNSDDLVIGRNSVLEALRVGVPASVLYVANRIEHDDRTREIVRLAGQHGLNLLEADRLEMDRIARSGNHQGVILKADPFQYSSLHELVERAERKARAMEMADSKASRLSARPLFIALDGITDPQNLGAVIRSAAAFGVNGVILPERRSASVNAAAWKVSAGAAAHMPIARVVNLTKAIEALKERGYYSIGLDGGGSKLVGETGFETDPLVVVLGSEGKGLSRLTREACDAIASIPITSAVESLNASVAAGIALYATVNARRKAGEAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUY5</accession>
    <name>B8DUY5_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4032 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218982.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1532"/>
    <dbReference type="EnsemblBacteria" id="ACL29814">
        <property type="protein sequence ID" value="ACL29814"/>
        <property type="gene ID" value="BLA_1532"/>
    </dbReference>
    <dbReference type="GeneID" id="66533929"/>
    <dbReference type="KEGG" id="bla:BLA_1532"/>
    <dbReference type="HOGENOM" id="CLU_035793_0_0_11"/>
    <dbReference type="OMA" id="EHRWYLS"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025111">
        <property type="entry name" value="DUF4032"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13224">
        <property type="entry name" value="DUF4032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4032" evidence="2">
        <location>
            <begin position="259"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="482" mass="54410" checksum="039EDA0C8352A874" modified="2009-03-03" version="1">MGITDNPQLDPRALKATSVKAEDPATPGPGPSTLKITAASSDPKMFTLPWEKPLATWPPELLVNLPRGISRHIVRFVHVGDEVYAMKEITRTVAEREYELLRQLQKLNLPTVQPIAVVTGRHDDNGEPLEAILVTKHLRFSMPYRALFARTLRPDTAERLIDALAVLMVRLHLAGFYWGDVSLSNVLFLKDADAFSAFLVDAETGDLQIELTAGQREYDIDLARTNIIGELMDLSSGELLPPDVDEISIGNRLVDRYHSLWSALTDTDNFSPNEMWKIEKRVNRLNELGFDVDELEMKTAEDGKRVLVRPRVVDAGYANRRLLRLTGLDVQENQARRLLNDLDAYRASSWREGEDLEIVATDWMREVFEPTVRMIPREYRSQIEPAQFFHEVLDHRWYMAEKAGHDVPMAEAVQSYIKNVLPQYQLDTKTVNELNADADAGVVDDEYTYDDASNNGAHTAPAAGHDDGYNPEDDPDAAVWAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV17</accession>
    <name>B8DV17_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Large-conductance mechanosensitive channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">mscL</name>
        <name evidence="12" type="ordered locus">BLA_0013</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MscL family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219038.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0013"/>
    <dbReference type="EnsemblBacteria" id="ACL28318">
        <property type="protein sequence ID" value="ACL28318"/>
        <property type="gene ID" value="BLA_0013"/>
    </dbReference>
    <dbReference type="GeneID" id="66532387"/>
    <dbReference type="KEGG" id="bla:BLA_0013"/>
    <dbReference type="HOGENOM" id="CLU_095787_1_0_11"/>
    <dbReference type="OMA" id="AWIIFLM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00115">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019823">
        <property type="entry name" value="Mechanosensitive_channel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001185">
        <property type="entry name" value="MS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="PTHR30266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01264">
        <property type="entry name" value="MECHCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="SSF81330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00220">
        <property type="entry name" value="mscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01327">
        <property type="entry name" value="MSCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACL28318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="166" mass="17525" checksum="59EA7A0270234A3B" modified="2009-03-03" version="1">MIDGFKKFIARGNMVDMAVGVVMGAAVTAVVNSVVDGIINPLVAAIFGKPDLSKTWNWTITNWAGENSVISFGSVLNALLNFLLIALAVYFCIVVPINNLRDMTEKAMAKVKGDDSDVAAEEPDLSPEEQTVILLQDIRNALAAQQPAGAHAAPVATDTTAAPESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV23</accession>
    <name>B8DV23_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Excinuclease ABC subunit A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">BLA_0019</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219044.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0019"/>
    <dbReference type="EnsemblBacteria" id="ACL28324">
        <property type="protein sequence ID" value="ACL28324"/>
        <property type="gene ID" value="BLA_0019"/>
    </dbReference>
    <dbReference type="GeneID" id="66532394"/>
    <dbReference type="KEGG" id="bla:BLA_0019"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.20"/>
    <dbReference type="HOGENOM" id="CLU_001370_2_1_11"/>
    <dbReference type="OMA" id="LMWDLMK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="2"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ACL28324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="833" mass="89737" checksum="3A292C73DDEE3CDC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV26</accession>
    <name>B8DV26_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0022"/>
    <dbReference type="EnsemblBacteria" id="ACL28327">
        <property type="protein sequence ID" value="ACL28327"/>
        <property type="gene ID" value="BLA_0022"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0022"/>
    <dbReference type="HOGENOM" id="CLU_055322_4_2_11"/>
    <dbReference type="OMA" id="PADWTAF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="182" mass="20134" checksum="6F332CD2B92C85CD" modified="2009-03-03" version="1">MKVLMIVGSLRKNSFNKQLAAMAEQELGDRASVSVLDWSEVPVFNQDEEFPTPKSVAEARVAVNEADAIWIFTPEYNHSVPGSLKNLFDWLSRPLEDGTPSVLTGKVMTMSGVGGLNTLRYAFAAWMPSLTLFKMRIVPVPFTGVTLNREMFSTDKLELNAAMRTSLKYQADATLQAIAEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV29</accession>
    <name>B8DV29_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219059.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28330">
        <property type="protein sequence ID" value="ACL28330"/>
        <property type="gene ID" value="BLA_0025"/>
    </dbReference>
    <dbReference type="GeneID" id="66532401"/>
    <dbReference type="KEGG" id="bla:BLA_0025"/>
    <dbReference type="HOGENOM" id="CLU_2506054_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="89" mass="10299" checksum="1FAC9AE240FE7394" modified="2009-03-03" version="1">MALFMLNHHVLAEVAYDSGARTYAVDFPDRQPWLPSGFSFQVCTAYTQVVSCEDSADTTIPADEKIRQMLNEQIEIWHRDWQCTGETWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV48</accession>
    <name>B8DV48_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Possible TetR-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0046</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219318.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0046"/>
    <dbReference type="EnsemblBacteria" id="ACL28349">
        <property type="protein sequence ID" value="ACL28349"/>
        <property type="gene ID" value="BLA_0046"/>
    </dbReference>
    <dbReference type="GeneID" id="66532422"/>
    <dbReference type="KEGG" id="bla:BLA_0046"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.50"/>
    <dbReference type="HOGENOM" id="CLU_069356_44_0_11"/>
    <dbReference type="OMA" id="HDEFANR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="213" mass="24704" checksum="3DB71936F6D5C096" modified="2009-03-03" version="1">MQPSVEESVNTRTRKSPQQREEEILRATVKLISQRGYNGISLRDVASEVGMTQQGVLHYVGNKAGLAAMVMKEFYDPTSMPGDFLASGLPGSDRDAPHFPAYLRYVVRENAKRRDLVQMFAILQAESIDPDHPAHDYFEHRPAIIWQTLSNYQWKLPPQIGTWENFKPLHRMALEAMDGIQLRWLRSDPIDLYDEWIAFERILFPSPVWDNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV69</accession>
    <name>B8DV69_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0067"/>
    <dbReference type="EnsemblBacteria" id="ACL28370">
        <property type="protein sequence ID" value="ACL28370"/>
        <property type="gene ID" value="BLA_0067"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0067"/>
    <dbReference type="HOGENOM" id="CLU_184264_0_0_11"/>
    <dbReference type="OMA" id="GGWKFFA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="80" mass="8809" checksum="EF28D1EF229AF827" modified="2009-03-03" version="1">MKGAVMEKKSSNGWKFFALLFGGLLAAVVGLYIYKQQNPDYDPWEEPWENSSSPVDLTLAQDKTEDDLDQPAADAAKDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV93</accession>
    <name>B8DV93_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Possible DO serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">degP</name>
        <name evidence="5" type="ordered locus">BLA_0091</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218388.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0091"/>
    <dbReference type="EnsemblBacteria" id="ACL28394">
        <property type="protein sequence ID" value="ACL28394"/>
        <property type="gene ID" value="BLA_0091"/>
    </dbReference>
    <dbReference type="GeneID" id="66532467"/>
    <dbReference type="KEGG" id="bla:BLA_0091"/>
    <dbReference type="HOGENOM" id="CLU_020120_3_8_11"/>
    <dbReference type="OMA" id="EIWTHKP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="458"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="564"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="564"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="613" mass="62791" checksum="3076522868B5AECC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVA3</accession>
    <name>B8DVA3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28404">
        <property type="protein sequence ID" value="ACL28404"/>
        <property type="gene ID" value="BLA_0101"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0101"/>
    <dbReference type="HOGENOM" id="CLU_3388247_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="32" mass="3455" checksum="F5C68B6E7B42CA7A" modified="2009-03-03" version="1">MAIVTHIKALPLLEQPAHDLRIAGEQPRAPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVB9</accession>
    <name>B8DVB9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable LysR-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218415.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0117"/>
    <dbReference type="EnsemblBacteria" id="ACL28420">
        <property type="protein sequence ID" value="ACL28420"/>
        <property type="gene ID" value="BLA_0117"/>
    </dbReference>
    <dbReference type="GeneID" id="66532492"/>
    <dbReference type="KEGG" id="bla:BLA_0117"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.121"/>
    <dbReference type="HOGENOM" id="CLU_039613_6_2_11"/>
    <dbReference type="OMA" id="WKKNQTF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="299" mass="33666" checksum="072526AAF9D2A052" modified="2009-03-03" version="1">MDIRTLRHFVAVVQEEGISAAADVLRMSQPALSRQMKELENELGVTLFERGNRGRSISLTKEGRVFYRRARQIIELADRARAEVHMHDEIAGTIHITAAESNLMNIVALAIAQTRLLYPRITFDIHDDNGPNNVERLNNGIADFAVIMQPIDMTRFDHLSLPGANPLGIGMRADDPIAANETITNELIRDMPLITSTGANQRRDLSGWLTQGTTLNIVSHVNLAYNAACLVRNGVGYMLTVNDLTEFSDPEHDLVWRPLDPPLDIRLSVIWRKDRDLSRVCQLFLQQLRTVITQIRTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVC4</accession>
    <name>B8DVC4_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">crcB</name>
        <name evidence="10" type="ordered locus">BLA_0122</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218420.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28425">
        <property type="protein sequence ID" value="ACL28425"/>
        <property type="gene ID" value="BLA_0122"/>
    </dbReference>
    <dbReference type="GeneID" id="66532497"/>
    <dbReference type="KEGG" id="bla:BLA_0122"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.128"/>
    <dbReference type="HOGENOM" id="CLU_114342_2_0_11"/>
    <dbReference type="OMA" id="FALICMC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL28425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="124" mass="13563" checksum="2B4E86ABA6A45BE0" modified="2009-03-03" version="1">MGTFLLVCICGGLGAVARFMLNTSIQRWWHRAYPLSTFIINIIAALCAGTAAAAYFYQTVNYSTYLLFVAGFLGGFSTFSTAINEMVSLTRTRQLAVAAFYFLTTLVVPFCAVVLGWFFGSIGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVE1</accession>
    <name>B8DVE1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sialic acid-specific 9-O-acetylesterase</fullName>
            <ecNumber evidence="4">3.1.1.53</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0139</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.53" evidence="4"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218446.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0139"/>
    <dbReference type="EnsemblBacteria" id="ACL28442">
        <property type="protein sequence ID" value="ACL28442"/>
        <property type="gene ID" value="BLA_0139"/>
    </dbReference>
    <dbReference type="GeneID" id="66532514"/>
    <dbReference type="KEGG" id="bla:BLA_0139"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.147"/>
    <dbReference type="HOGENOM" id="CLU_015150_0_0_11"/>
    <dbReference type="OMA" id="PCEFKAC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106331">
        <property type="term" value="F:sialate 4-O-acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106330">
        <property type="term" value="F:sialate 9-O-acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005181">
        <property type="entry name" value="SASA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039329">
        <property type="entry name" value="SIAE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22901">
        <property type="entry name" value="PTHR22901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03629">
        <property type="entry name" value="SASA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SASA" evidence="3">
        <location>
            <begin position="120"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="SASA" evidence="3">
        <location>
            <begin position="308"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="565" mass="61558" checksum="A2120C9B0F52676D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVE3</accession>
    <name>B8DVE3_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Beta-glucosidase</fullName>
            <ecNumber evidence="3 11">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">BLA_0141</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3 11"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218448.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="SMR" id="B8DVE3"/>
    <dbReference type="STRING" id="442563.BLA_0141"/>
    <dbReference type="CAZy" id="GH1">
        <property type="family name" value="Glycoside Hydrolase Family 1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28444">
        <property type="protein sequence ID" value="ACL28444"/>
        <property type="gene ID" value="BLA_0141"/>
    </dbReference>
    <dbReference type="GeneID" id="66532516"/>
    <dbReference type="KEGG" id="bla:BLA_0141"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.149"/>
    <dbReference type="HOGENOM" id="CLU_001859_1_0_11"/>
    <dbReference type="OMA" id="WHVCEHG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017736">
        <property type="entry name" value="Glyco_hydro_1_beta-glucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03356">
        <property type="entry name" value="BGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6 11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="420"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 10">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACL28444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="460" mass="52143" checksum="7AB749B652E10AEE" modified="2009-03-03" version="1">MTMTFPKGFQFGTATAAYQIEGAVDEDGRTPSIWDVFSHAPGRVLNGDTGDKADDFYHRWQDDLKLVRDLGVNAYRFSIGVPRVIPTPDGKPNEKGLDFYERIVDQLLEYGIDPIVTLYHWDLPQYLNEDPYRDGWLNRETAFRMAEYAGIVAKRLGDRVHTYTTLNEPWCSAHLSYGGTEHAPGLGAGPLAFRAAHHLNLAHGLMCEAVRAEAGAKPDLSVTLNLQVNRGDADAVHRVDLIANRVFLDPMLRGYYPDELFAITKGICDWDFVHDGDLKLINQPIDVLGLNYYSTNLLAMSDRPQFPQSTEASTAPGASDIDWLPTDGPHTQMGWNIDPDALYNTLVRLNDDYDHIPLVVTENGMACPDEVEVGPDGVKMVHDDDRIDYLRRHLEAVHRAIEEGANVIGYFVWSLMDNFEWAFGYDRRFGLTYVDYDTEERIRKDSYNWYRNFIAEHSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVH4</accession>
    <name>B8DVH4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28475">
        <property type="protein sequence ID" value="ACL28475"/>
        <property type="gene ID" value="BLA_0173"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0173"/>
    <dbReference type="HOGENOM" id="CLU_1088454_0_0_11"/>
    <dbReference type="OMA" id="RAHENEF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="251" mass="27744" checksum="6BFE7559A7F97FE2" modified="2009-03-03" version="1">MNDVNPYAAAAHIEVLPLTPTRQSIERALVEWMTQTGRPASDLSVSALCKKAFVARSTFYANYRHMGQVYESVENRLLRQLFECAVPMRVRADGTDETMRSFNAFVKVLHAHENEFRLVLVRQPSSRFVALWKQSLEYHVWHRLFETERGGAAAVDAVAEWGDGAAPGTSNGGSATSQEGLPAGTDADATNRNELPVRQGPATVNRALVFDMAATAFIAGVTFWLRTPQAVSLPEIRASVVKLVNNIDEIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVH9</accession>
    <name>B8DVH9_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">amt</name>
        <name evidence="10" type="ordered locus">BLA_0178</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218495.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0178"/>
    <dbReference type="EnsemblBacteria" id="ACL28480">
        <property type="protein sequence ID" value="ACL28480"/>
        <property type="gene ID" value="BLA_0178"/>
    </dbReference>
    <dbReference type="GeneID" id="66532554"/>
    <dbReference type="KEGG" id="bla:BLA_0178"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.188"/>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_11"/>
    <dbReference type="OMA" id="MACWNSN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002229">
        <property type="entry name" value="RhesusRHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="PTHR43029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00342">
        <property type="entry name" value="RHESUSRHD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="9">
        <location>
            <begin position="10"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL28480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="431" mass="45002" checksum="A46815AAB6413B91" modified="2009-03-03" version="1">MSQLDSGNAAWILTSACLVFLMTPGVALFYGGMVRAKAVLNMLIMEAAALSVTMIIWGLWGWSIAYAGNSIGGVFGDPATGFLLRDTMVAQDGVFTSASLNSNNYPASVDVAFQAAFAMITVALICGAIAERVKYSTWMIFVALWITFDYAPMAHMVWNGGLLSADGAISQALGAAAHDFAGGTVVHINAAVAALIIVLIIGKRKGFGVEPMRPHNVPFVMLGAFLLWFGWFGFNAGSAFAANGVAGYAWVSTSLAAAAAMLTWGFTEKIRTGHYTAMGAASGIVAGLVAITPAADVVSPIWAIVLGAIAGVVTCLACSLKFKLGYDDSLDVVGVHGVGGLVGTVLLGFFMEGTGLFYSGKWNQLGVQLIIAIIAIAFSAVITTIIAFALEKTIGWRVTQAQEVAGIDLADQGERAYDFAGTASSVIREMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVJ7</accession>
    <name>B8DVJ7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II secretion system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218513.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0196"/>
    <dbReference type="EnsemblBacteria" id="ACL28498">
        <property type="protein sequence ID" value="ACL28498"/>
        <property type="gene ID" value="BLA_0196"/>
    </dbReference>
    <dbReference type="GeneID" id="66532570"/>
    <dbReference type="KEGG" id="bla:BLA_0196"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.206"/>
    <dbReference type="HOGENOM" id="CLU_093395_0_0_11"/>
    <dbReference type="OMA" id="RSRAEWW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867647" evidence="2">
        <location>
            <begin position="23"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="244" mass="25355" checksum="0F815C92F0A5C059" modified="2009-03-03" version="1">MAFVAALAAALSVLLMIWAAPAAVSWRLQTVESGVADHACEPACGISVMLSSIIASLQAGAALEPALERAFDSVFPERRCGGARARHMRDPTTSGDGHAVGVYAVCDGEGNVDVTQMARLFAACRLPHERASHCAQVACGVAVASAVSLELGCPAARCLEAVRAGYLRARLQDDLRANAFAMPKSTARMLLALPAVVVFLGELLGADPLGMLFGSAQGRAMLCLGTICYVGGLLWMQRLLAADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVK4</accession>
    <name>B8DVK4_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Aspartokinase</fullName>
            <ecNumber evidence="6 9">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">askA</name>
        <name evidence="12" type="ordered locus">BLA_0203</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 10">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="6 9"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218520.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0203"/>
    <dbReference type="EnsemblBacteria" id="ACL28505">
        <property type="protein sequence ID" value="ACL28505"/>
        <property type="gene ID" value="BLA_0203"/>
    </dbReference>
    <dbReference type="GeneID" id="66532577"/>
    <dbReference type="KEGG" id="bla:BLA_0203"/>
    <dbReference type="HOGENOM" id="CLU_009116_3_0_11"/>
    <dbReference type="OMA" id="MLEMSSC"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04261">
        <property type="entry name" value="AAK_AKii-LysC-BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041740">
        <property type="entry name" value="AKii-LysC-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="11">
        <location>
            <begin position="3"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00016273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACL28505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="254" mass="26827" checksum="DC9AB4BFB86128A2" modified="2009-03-03" version="1">MALIVQKYGGSSVADADSIKRVARRIIETKNAGNDVAVVVSAMGDTTDDLIDQAMSIDSNPPAREMDMLMTAGERISMSLLAMAIHAAGSHAYSFTGSQAGFMTDAQFGAAHIRAVNPDRVRRALNKGSVAIVAGFQGQSERGDATTLGRGGSDTSAVALAVALGADVCEIYTDVDGVFTADPRIVPTARRIPAIGYDEILEMSSCGSKVLALRCVEYAQRFKMPLHVRSSFSHRPGTLVLPDGVDPNSLPNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVM4</accession>
    <name>B8DVM4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219297.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0223"/>
    <dbReference type="EnsemblBacteria" id="ACL28525">
        <property type="protein sequence ID" value="ACL28525"/>
        <property type="gene ID" value="BLA_0223"/>
    </dbReference>
    <dbReference type="GeneID" id="66532597"/>
    <dbReference type="KEGG" id="bla:BLA_0223"/>
    <dbReference type="HOGENOM" id="CLU_033323_5_1_11"/>
    <dbReference type="OMA" id="DPRKRQC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="219" mass="24911" checksum="6082E637556B538B" modified="2009-03-03" version="1">MPATTINFVRHGKVYNPDHLLYERLPDFHLSERGRRMAQATGRYIAQSPQLNTAVAVYSSPLDRTRETANEILLELNKVRAERGQEALGLLTDERIIEAGNEFRGTRIGHGEGALWKPRNLKLVRNLWTPSWGESYRSIAARVQDFALEKVHEYPGEQIVVVTHESPIWSYRHMLETGHPEHNMLLRKTALASVTSITYDSETGKVLSITYADPAKHID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVM6</accession>
    <name>B8DVM6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28527">
        <property type="protein sequence ID" value="ACL28527"/>
        <property type="gene ID" value="BLA_0225"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0225"/>
    <dbReference type="HOGENOM" id="CLU_041900_3_3_11"/>
    <dbReference type="OMA" id="FESHTSW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_ISL3" evidence="1">
        <location>
            <begin position="174"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="443" mass="50262" checksum="5E40D036242CC0C8" modified="2009-03-03" version="1">MNEETRPEPEFSVFDPQRFLGLDEMGLRVLSWRRLGRPDGPGLRQIRCEPDSHDARWCPSCGAYARVRSSWLRTLAHVPYGDDAVHLLVRVRRYECVPCSRSWSDDLEAVGAGRGVLSVPAVMWALRRVCLDSMTVSACARLLHVAWAVVDRAVRERGMLLLEQADRFSSVRAIGVDEHVWRHGAFGDRYVTVIVDLTPRCDGRPARLLDMVPGRSAQVLREWMQARGGEFTRRVGVVAMDAFAGWKQAVESVVPHAVEVIDPFHVVQLAAARVTKVRCRLQRDATGRRGVKGDRLYDCRRALLTSDEYLGARGRARLMALFAIQANRDLMLAHDAYQRVIHAYRCDDRRRGERMMRELIDDLTGPGRYKGCRELASLGRVLKRRMRDILALFRHPRSSNGPTEAINGRLETLRGNAMGFANTTSYIQRCLIHSSQLKDILTH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVN7</accession>
    <name>DDL_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="2">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ddl</name>
        <name type="ordered locus">BLA_0236</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268324.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DVN7"/>
    <dbReference type="SMR" id="B8DVN7"/>
    <dbReference type="STRING" id="442563.BLA_0236"/>
    <dbReference type="EnsemblBacteria" id="ACL28538">
        <property type="protein sequence ID" value="ACL28538"/>
        <property type="gene ID" value="BLA_0236"/>
    </dbReference>
    <dbReference type="GeneID" id="66532612"/>
    <dbReference type="KEGG" id="bla:BLA_0236"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.251"/>
    <dbReference type="HOGENOM" id="CLU_039268_0_1_11"/>
    <dbReference type="OMA" id="NTTPGMT"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01205">
        <property type="entry name" value="D_ala_D_alaTIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00843">
        <property type="entry name" value="DALA_DALA_LIGASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00844">
        <property type="entry name" value="DALA_DALA_LIGASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000117449" description="D-alanine--D-alanine ligase">
        <location>
            <begin position="1"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="149"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="189"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <sequence length="378" mass="40445" checksum="23FCACC423C71CB1" modified="2009-03-03" version="1">MAKTRVAVLYGGKADEHSISCISAASFMRALDPELFEAVPIGITKTGTWFVDGQDPLGWNLAEGLPEAVETPDSREVVLTIGDGGDGFHARNADGSLDSLGHIDVVLPALHGPFGEDGTIQGLFEMMGVPYVGCGVLASAACMDKHYTKVLLRAAGIPVAPGITLDTRHYDASDEFATDGEEFLRQVNEAGLQYPLFVKPSRAGSSFGVTKVEQIGDAAALAAAVFEASRHDWRVLVEQGIDAREIECAVVRIHPTDPTRAALPGEVVLDRRSEGDDQFYDFDSKYMDSQASHTEIPAKIGDDLIARVRETAVRAFDAVDGMGLSRVDTFVTADGDVLVNEINTLPGCTSISMFPQAWEAMGIPFRTVVTDLIEGALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVP3</accession>
    <name>B8DVP3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_0242</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268997.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0242"/>
    <dbReference type="EnsemblBacteria" id="ACL28544">
        <property type="protein sequence ID" value="ACL28544"/>
        <property type="gene ID" value="BLA_0242"/>
    </dbReference>
    <dbReference type="GeneID" id="66532618"/>
    <dbReference type="KEGG" id="bla:BLA_0242"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.257"/>
    <dbReference type="HOGENOM" id="CLU_055257_2_2_11"/>
    <dbReference type="OMA" id="ADEQWRE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010540">
        <property type="entry name" value="CmpB_TMEM229"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06541">
        <property type="entry name" value="ABC_trans_CmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL28544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="288" mass="32853" checksum="DE1B1E3B03A9FEDC" modified="2009-03-03" version="1">MWLAAVEKTFVWFLLYSFVGWVWETGLNIVMKRRFVDRGILNGPICPIYGFGAALAIFVLHDEHSLIAVFLSSGVLACTLEYITSWGIEKLFHMRLWDYSNKPFNINGRVYLNGFLFFAAGCTVVKEWVQPAVMRMLDRLDPLWLNIVSITLFVILMADVAVTLAGLISMNGKLGRAEEYIKSVKKEQIAKMDVHITAADERIEQIEQHAEGVASRVKESVYEHVGVHVDGARERMRDGELAEKLHGTFNWQQRRLLDAYPEMKPEHGRSVIGEIRAQLAKYGRKHNA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVQ6</accession>
    <name>RS16_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsP</name>
        <name type="ordered locus">BLA_0255</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268360.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DVQ6"/>
    <dbReference type="SMR" id="B8DVQ6"/>
    <dbReference type="STRING" id="442563.BLA_0255"/>
    <dbReference type="EnsemblBacteria" id="ACL28557">
        <property type="protein sequence ID" value="ACL28557"/>
        <property type="gene ID" value="BLA_0255"/>
    </dbReference>
    <dbReference type="GeneID" id="66532630"/>
    <dbReference type="KEGG" id="bla:BLA_0255"/>
    <dbReference type="HOGENOM" id="CLU_100590_1_0_11"/>
    <dbReference type="OMA" id="FDRALYW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020592">
        <property type="entry name" value="Ribosomal_S16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00732">
        <property type="entry name" value="RIBOSOMAL_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000196338" description="30S ribosomal protein S16">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="156" mass="17069" checksum="D45D65F47D669A44" modified="2009-03-03" version="1">MATKIRLKRMGKKFYAVYRVVVMDSRTKRDGRAIEEIGLYNPNTQPSTIEIKSDRAQYWLGVGAQPTDQVLNLLKITGDWQKFKGLKGAEGTLKTAAAKPEAAVLVEEAENKAQKLKAAKAEAAAKAAEAETPAEVQHDDEKVELADVEESAPESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVQ8</accession>
    <name>B8DVQ8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0257</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268364.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0257"/>
    <dbReference type="EnsemblBacteria" id="ACL28559">
        <property type="protein sequence ID" value="ACL28559"/>
        <property type="gene ID" value="BLA_0257"/>
    </dbReference>
    <dbReference type="GeneID" id="66532632"/>
    <dbReference type="KEGG" id="bla:BLA_0257"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.272"/>
    <dbReference type="HOGENOM" id="CLU_052333_1_1_11"/>
    <dbReference type="OMA" id="NLTFPRW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="126"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="389" mass="42373" checksum="A85651828C205BBA" modified="2009-03-03" version="1">MIIALWVILVLLLVWISLSELPAGWDGHAPLPYLIALSPFAWIGITAVAIWSGCLREWPLMACAIVGLIASLLRKTAYYMNDLKTPNTGELIARKLAEKRESENLTISSNSAAVENLANGHFNVFTLNCRYGEANAHEIVNTVRTNDIAVLALQEMSPDLVTELHDAGLDDLLPFHQFGDPSSSDNGGFNGLWLRVEPAEQTPTGVPIPAADVPTVTLPVTSTFNITFASAHPKSPQRSCKDWSAGIIGLGALAKSANKDRDRNADDSCNNREIAVLMGDLNSSIVHPSFRELLASGFHDAALVEARGEHPTYPSWLKWPRIVIDHILFTDFMTASNVRAVFIDGTDHLGLTATLTIRDTRTQANAAARESWPSSLPPLPAKSRRKTAD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVS0</accession>
    <name>COAD_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="1">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaD</name>
        <name type="ordered locus">BLA_0269</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial CoaD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268387.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DVS0"/>
    <dbReference type="SMR" id="B8DVS0"/>
    <dbReference type="STRING" id="442563.BLA_0269"/>
    <dbReference type="EnsemblBacteria" id="ACL28571">
        <property type="protein sequence ID" value="ACL28571"/>
        <property type="gene ID" value="BLA_0269"/>
    </dbReference>
    <dbReference type="GeneID" id="66532644"/>
    <dbReference type="KEGG" id="bla:BLA_0269"/>
    <dbReference type="HOGENOM" id="CLU_100149_1_1_11"/>
    <dbReference type="OMA" id="EFQMALM"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02163">
        <property type="entry name" value="PPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00151">
        <property type="entry name" value="PPAT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001980">
        <property type="entry name" value="PPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PTHR21342:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01020">
        <property type="entry name" value="LPSBIOSNTHSS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01510">
        <property type="entry name" value="coaD_prev_kdtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000123264" description="Phosphopantetheine adenylyltransferase">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="90"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="124"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00151"/>
        </source>
    </evidence>
    <sequence length="159" mass="17508" checksum="E2B2DF9F52C7818F" modified="2009-03-03" version="1">MTIAVCPGSFDPVTNGHIDVITRCCRLFDEVHVVVAVNAMKKPLFTETERVDIIKHALADSGMTNYVVAWTDGLITDYCRKVDSPVIVKGLRQNGDYEAELGMALVNRHLAYVETMFLPANPVLEHISSSVVKDVARHGGDITGMVPDYVVPLLEKALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVT4</accession>
    <name>B8DVT4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding protein of ABC transporter system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_0283</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0283"/>
    <dbReference type="EnsemblBacteria" id="ACL28585">
        <property type="protein sequence ID" value="ACL28585"/>
        <property type="gene ID" value="BLA_0283"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0283"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OMA" id="FARAIMS"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="16"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="66"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL28585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="281" mass="29886" checksum="A87E15DCB78EFCD3" modified="2009-03-03" version="1">MPYPDGAPMGGQSLALQGIDLVMDYNTSASGNPAATQPAAWQMGQPLALNHANFQLGEGERVAIMGPSGSGKSTLLHVLAGIMKPTAGQVLFRGANIDRIPDAERTRMRRQAFGFVFQSGQLLPELPAIENVALPLMLGGMAYSQATDQAAMWLERMGLRNLMRNRPGQMSGGQMQRVAIARALCVNPAIIFADEPTGALDQNTGHEVMNLLMQAAAANNAAVVLVTHDPNIAAYCDRTVSMRDGMILDAANRRAGMQRQPQNDAPAQAVQMGAQPQGALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVT7</accession>
    <name>B8DVT7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinyl-diaminopimelate desuccinylase</fullName>
            <ecNumber evidence="2">3.5.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dapE</name>
        <name evidence="2" type="ordered locus">BLA_0286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0286"/>
    <dbReference type="EnsemblBacteria" id="ACL28588">
        <property type="protein sequence ID" value="ACL28588"/>
        <property type="gene ID" value="BLA_0286"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0286"/>
    <dbReference type="HOGENOM" id="CLU_021802_1_0_11"/>
    <dbReference type="OMA" id="LNSHHDT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009014">
        <property type="term" value="F:succinyl-diaminopimelate desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010174">
        <property type="entry name" value="Succinyl-DAP_deSuclase_DapE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01900">
        <property type="entry name" value="dapE-gram_pos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="197"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="403" mass="43278" checksum="9C39C54FA58C4E7C" modified="2009-03-03" version="1">MIDRAGEPLKLTVDAGVGEQAALTDLCMQVMRVYSVSDDETHLTDMTEAFLRTLPHLDVQRHGDTLVARTNLGRDRRVVLAGHLDVVPVIDNFPPKLLEPGDPLILPGVAEAHPGERVVWGRGATDMKSSDAVLLYLAATLTNPKYDLTYVFYDHEEVAAEKNGLRKVAEAHPDWIAGDFAIIGEPTSCGIEGGCNGTIRFDVVTHGIAAHSARAWMGHNAIHDAAEILRRLNEHTDATVSVDGLVYREGLNATLISGGKGTNVIPDECRVHVNYRFAPDKSLAEAKALMMGADCGAELGNGEHQATGGVFEGFGIEMKDESPSARPGMDSELTRSLAALAKARTGKDPEAKLGWTDVARFSQLGVPAVNFGAGSPLLAHKHDEQVAEGELTLMAGILRDWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVV6</accession>
    <name>B8DVV6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L-lactate dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.1.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ldh</name>
        <name evidence="6" type="ordered locus">BLA_0305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the LDH/MDH superfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.27" evidence="6"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268463.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="SMR" id="B8DVV6"/>
    <dbReference type="STRING" id="442563.BLA_0305"/>
    <dbReference type="EnsemblBacteria" id="ACL28607">
        <property type="protein sequence ID" value="ACL28607"/>
        <property type="gene ID" value="BLA_0305"/>
    </dbReference>
    <dbReference type="GeneID" id="66532684"/>
    <dbReference type="KEGG" id="bla:BLA_0305"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.327"/>
    <dbReference type="HOGENOM" id="CLU_045401_1_2_11"/>
    <dbReference type="OMA" id="IVSHYDD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018177">
        <property type="entry name" value="L-lactate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00064">
        <property type="entry name" value="L_LDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="5">
        <location>
            <begin position="155"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL28607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="323" mass="35116" checksum="7BE1DA0636B08AA6" modified="2009-03-03" version="1">MGICTKIGIVGMGHVGAHVANSLVLQGIADELYMTEICSGERDRSKKLAAEVQDLGDSLAFCPHNVALHNCGDDYAQLAQCDVIVNCAGDVSLSSKDRDGELFFTTDTAKTFIKTIADAGFHGIWITIANPCDVVATEIWKESGMDPRRIIGTGTALDSSRLKYVLSRVTGYDQHSITAYMLGEHGNSQFAAWSNVYFGGKPLSQLAMEQPERFAFDYAELEAEARKGGYVTYAGKHCTEFAVADAACRLVRAVISNEHYITACSTLLTGEYGEEGFFISLPCVVGADGVEEVMRLDLSDAEIDEFRKSCAHVKENLARTHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVW0</accession>
    <name>B8DVW0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0309"/>
    <dbReference type="EnsemblBacteria" id="ACL28611">
        <property type="protein sequence ID" value="ACL28611"/>
        <property type="gene ID" value="BLA_0309"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0309"/>
    <dbReference type="HOGENOM" id="CLU_022361_0_0_11"/>
    <dbReference type="OMA" id="YHGDIEY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018702">
        <property type="entry name" value="DUF2207_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09972">
        <property type="entry name" value="DUF2207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="571" mass="61511" checksum="9BA349F95146C8A3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVX5</accession>
    <name>B8DVX5_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Adenosylhomocysteine nucleosidase</fullName>
            <ecNumber evidence="2">3.2.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mtnN</name>
        <name evidence="7" type="ordered locus">BLA_0324</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 1/2.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.9" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268494.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0324"/>
    <dbReference type="EnsemblBacteria" id="ACL28626">
        <property type="protein sequence ID" value="ACL28626"/>
        <property type="gene ID" value="BLA_0324"/>
    </dbReference>
    <dbReference type="GeneID" id="66532703"/>
    <dbReference type="KEGG" id="bla:BLA_0324"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.348"/>
    <dbReference type="HOGENOM" id="CLU_031248_2_0_11"/>
    <dbReference type="OMA" id="DQFVHSK"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008782">
        <property type="term" value="F:adenosylhomocysteine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008930">
        <property type="term" value="F:methylthioadenosine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010049">
        <property type="entry name" value="MTA_SAH_Nsdase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01704">
        <property type="entry name" value="MTA/SAH-Nsdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="6">
        <location>
            <begin position="4"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL28626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="230" mass="24581" checksum="727BE906B3BA4278" modified="2009-03-03" version="1">MQTVAIISALDEEAAHIADSLDNMTVTERASLSVARGTLTTDAGEELDVAVTVGGMGLVNAAATTQFLIDLVHPEAVIFSGIAGNLNKSLHINDIVLGKTLRYLDTDMRLVGQWKPGTSEFHSDPALLQIAEGALDEMGINHIQGTIASGNYFVDTPQKVSQVIEQTHADAVEMEGAAVAHVAARNDVPALVIRAMSDSADTDYEEFKDFDISEYADTAARLVVRILRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVZ3</accession>
    <name>B8DVZ3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268531.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0342"/>
    <dbReference type="EnsemblBacteria" id="ACL28644">
        <property type="protein sequence ID" value="ACL28644"/>
        <property type="gene ID" value="BLA_0342"/>
    </dbReference>
    <dbReference type="GeneID" id="66532721"/>
    <dbReference type="KEGG" id="bla:BLA_0342"/>
    <dbReference type="HOGENOM" id="CLU_057829_0_0_11"/>
    <dbReference type="OMA" id="EHREDRF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="407" mass="44769" checksum="54ABEF8B47E39F98" modified="2009-03-03" version="1">MDYESLSTIVLVVIVAILMVSWLPRRTVQGMKQVIKHQSDRYSASLHLIDEGDGTRFSDARTVELKGTPMASPHTVRDREYVAQVRDLRRAAARRRKILVGALLGISVLVFVLAVILVFSPYFTLIPIALMCVVLALGAHASRQAREWEDRHAQRQRELKERKVRENKRVVEERTRAAHPEPSARRQMQDGSQTDVMEAREIHQALQRAREEQARAIARRKAQDTRDHHADEASLRSGMRAEHADVDAAVQAAEEATHNPGHLTIREERAAQMSDETNELAQINASSAPDAFDMAVNQDLISFSLGSDPFDGPEVVQSMEIKSTRQVSKAVPKDSSSAKPADAGAAESRDAAADNADVKEAQTVSAVSVNDSVAFHNSEAQANVEAPDASSDSLGVDLQSILARRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW00</accession>
    <name>B8DW00_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase IV</fullName>
            <shortName evidence="3">Pol IV</shortName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dinB</name>
        <name evidence="6" type="ordered locus">BLA_0349</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268548.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0349"/>
    <dbReference type="EnsemblBacteria" id="ACL28651">
        <property type="protein sequence ID" value="ACL28651"/>
        <property type="gene ID" value="BLA_0349"/>
    </dbReference>
    <dbReference type="GeneID" id="66532731"/>
    <dbReference type="KEGG" id="bla:BLA_0349"/>
    <dbReference type="HOGENOM" id="CLU_012348_1_0_11"/>
    <dbReference type="OMA" id="CKPDGLL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01113">
        <property type="entry name" value="DNApol_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0515">Mutator protein</keyword>
    <keyword evidence="3 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="5">
        <location>
            <begin position="23"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Substrate discrimination" evidence="3">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL28651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="438" mass="47941" checksum="C2B66C8FDAC37ABE" modified="2009-03-03" version="1">MSTAPRIEAAKRDWGHDETGCTILHIDMDAFFASLEIARHPEFRGKPVIVGTGNRAVVSAASYEARKYGINSAMPAARAHQLCPNGIFLPVDHHYYSAVSHEIFHTVFREVTDRIEQVSVDECYMDVSGALLAWHSPTRIAQWLRAQVAERFGITCSVGIAGNKLVAKMASTNAKPNGMLLIPLDKHAQFVQLMPLRGIPGLGPAQEKRLNAWGINSVSQLARCSVEELIQATGSKAAATHLWEASHGIDPCTLTLHAPEKSIGQERTFDTDCNDLATASTLIKQCCDKVASILRAKGLMARTLTVKLRFPDLAYSTKQMQLEQPTDAASTLYPHAIDLLLRMMGMPADCRGTEVKLTRPIRLAGISTSTLTKREETVIQPTLDELLEENERVAPMPQASSSIPSPANGTRSTRLRCAEEAVDQIRRKFGQDSAHLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW31</accession>
    <name>B8DW31_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rpmD</name>
        <name evidence="8" type="ordered locus">BLA_0380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268605.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0380"/>
    <dbReference type="EnsemblBacteria" id="ACL28682">
        <property type="protein sequence ID" value="ACL28682"/>
        <property type="gene ID" value="BLA_0380"/>
    </dbReference>
    <dbReference type="GeneID" id="66532763"/>
    <dbReference type="KEGG" id="bla:BLA_0380"/>
    <dbReference type="HOGENOM" id="CLU_131047_2_0_11"/>
    <dbReference type="OMA" id="ALFQIAH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_B">
        <property type="entry name" value="Ribosomal_L30_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_L30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002211">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L30" evidence="7">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="60" mass="6535" checksum="5950BFB79A241C9E" modified="2009-03-03" version="1">MAKLKITLVHGVAHANKKQKATVQTLALRKIGQSTVLEDNSSTRGMIAVVRHLVNVEEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW32</accession>
    <name>B8DW32_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">rplO</name>
        <name evidence="10" type="ordered locus">BLA_0381</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268606.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0381"/>
    <dbReference type="EnsemblBacteria" id="ACL28683">
        <property type="protein sequence ID" value="ACL28683"/>
        <property type="gene ID" value="BLA_0381"/>
    </dbReference>
    <dbReference type="GeneID" id="66532764"/>
    <dbReference type="KEGG" id="bla:BLA_0381"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.408"/>
    <dbReference type="HOGENOM" id="CLU_055188_4_1_11"/>
    <dbReference type="OMA" id="FKNINRV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_L15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="PTHR12934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="9">
        <location>
            <begin position="34"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL28683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="152" mass="16197" checksum="B3F355075543F3A8" modified="2009-03-03" version="1">MANEETTILQMHDLKPAPGARKDRIRVGRGEGSKGKTSGRGDKGTKKRYQVRPGFEGGQLPLYMRLPKLRGFRSPFKTEYQVVNIAALNDLFPQGGEITVADLVAKGAVRANRPVKVLGEGEATAAFTLKGVKASASAKSKIEAAGGSISED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW34</accession>
    <name>B8DW34_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Adenylate kinase</fullName>
            <shortName evidence="6">AK</shortName>
            <ecNumber evidence="6 8">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">adk</name>
        <name evidence="9" type="ordered locus">BLA_0383</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6 8"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268609.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0383"/>
    <dbReference type="EnsemblBacteria" id="ACL28685">
        <property type="protein sequence ID" value="ACL28685"/>
        <property type="gene ID" value="BLA_0383"/>
    </dbReference>
    <dbReference type="GeneID" id="66532766"/>
    <dbReference type="KEGG" id="bla:BLA_0383"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.410"/>
    <dbReference type="HOGENOM" id="CLU_032354_4_1_11"/>
    <dbReference type="OMA" id="FHNRMRV"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMP" evidence="6">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL28685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="190" mass="20800" checksum="F35D5E1322779CEC" modified="2009-03-03" version="1">MRLLIMGPQGVGKGTQAKLLAEHYGIPTISTGDIFRANIKNKTELGKKVLEYTSQGFLVPDELTNEIVRDRLAQDDAKNGWILDGYPRNVAQVSALDEILEGLGEQLDAVVALTAPTNVLLERMAKRAKEEGRADDTPEAIQNRLNTYDKETTPVLDIYQQRGKLVTVNGVGEIDAISEEIVKALDAKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW64</accession>
    <name>B8DW64_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">O-acetylhomoserine sulfhydrylase</fullName>
            <ecNumber evidence="3">4.4.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619712.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0413"/>
    <dbReference type="EnsemblBacteria" id="ACL28715">
        <property type="protein sequence ID" value="ACL28715"/>
        <property type="gene ID" value="BLA_0413"/>
    </dbReference>
    <dbReference type="GeneID" id="66532797"/>
    <dbReference type="KEGG" id="bla:BLA_0413"/>
    <dbReference type="HOGENOM" id="CLU_018986_7_1_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080146">
        <property type="term" value="F:L-cysteine desulfhydrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044540">
        <property type="term" value="F:L-cystine L-cysteine-lyase (deaminating)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="81" mass="9079" checksum="B818CC649692E0B7" modified="2009-03-03" version="1">MDGGREQVARILDGTHVFTYVPNIGDARSLIVDPARITHREVSPEFRRMSGVDDNLIRLSIGLEDTADLIADLEQAIRRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW66</accession>
    <name>B8DW66_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Large tegument protein</fullName>
            <ecNumber evidence="3">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.6.99.5" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268683.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28717">
        <property type="protein sequence ID" value="ACL28717"/>
        <property type="gene ID" value="BLA_0415"/>
    </dbReference>
    <dbReference type="GeneID" id="66532800"/>
    <dbReference type="KEGG" id="bla:BLA_0415"/>
    <dbReference type="HOGENOM" id="CLU_780022_0_0_11"/>
    <dbReference type="OMA" id="FEMVYSK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="353" mass="36338" checksum="35C70B47C4E2D201" modified="2009-03-03" version="1">MNPNENNGAQPSNDLPPYAQPTPAPQPAQGSPSPQGQQPAYANAQSAPQQPQSVSQTPHDAPQFAQNTPQGAPAGTTTVDMKESVNKFADALGKQHLKIGNHEVAYGNLVTVVGALLAIIGVFLPFASISAFGVSMSVSLMPHGDGWILLIGAVVIAVLAVLRQEIAALTVTIIYTLLVIYEIAAAGSKISQSGYGTLLQLSYGAGMWLLIIAIIVMLIGTIFAFYNKQRAKNAQNGAPAMPVQNPAYDASYQDNGWQFGVPAQSDPSNVDNSQWQFGVENPPADAGVQQGTPVAPAPNAAAPVPPAVAHEPFNAAPDASATPAAPAAPAAPAAPAQPTIPPASQDPDSQDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW74</accession>
    <name>B8DW74_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">2,3-bisphosphoglycerate-dependent phosphoglycerate mutase</fullName>
            <shortName evidence="4">BPG-dependent PGAM</shortName>
            <shortName evidence="4">PGAM</shortName>
            <shortName evidence="4">Phosphoglyceromutase</shortName>
            <shortName evidence="4">dPGM</shortName>
            <ecNumber evidence="4 5">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gpm</name>
        <name evidence="4" type="synonym">gpmA</name>
        <name evidence="6" type="ordered locus">BLA_0423</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="4 5"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0423"/>
    <dbReference type="EnsemblBacteria" id="ACL28725">
        <property type="protein sequence ID" value="ACL28725"/>
        <property type="gene ID" value="BLA_0423"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0423"/>
    <dbReference type="HOGENOM" id="CLU_033323_1_5_11"/>
    <dbReference type="OMA" id="RMLPYWY"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046538">
        <property type="term" value="F:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PTHR11931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="74"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="87"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="153"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="246"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="4">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL28725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="311" mass="34636" checksum="C08F3C9B42814F81" modified="2009-03-03" version="1">MWPSGNTVAPCGICRGSRSPSRWCSSVSPCPSECAEIVAFADYPANRADMAMHVHLTRRVARLGHMTYKLVLLRHGQSEWNKTNQFTGWVDVPLTEKGREEAKNGGKLMKDKGVLPDIVFTSLLRRAINTANIALDEADRLWIPVKRDWRLNERHYGALQGKNKTEIREEYGDEKFMLWRRSYGTPPPEIDPNDQYAQNNDPRYAGDPVPEAECLADVVARVEPYWEAEIIPELKSGKTVLIAAHGNSLRAIVKMLDGLTEEEIAKVNIPTAIPLVYELDENFKPIKKGGEYLDPEAAAAGAAAVAAQGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW88</accession>
    <name>B8DW88_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">trmB</name>
        <name evidence="3" type="ordered locus">BLA_0438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268728.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0438"/>
    <dbReference type="EnsemblBacteria" id="ACL28739">
        <property type="protein sequence ID" value="ACL28739"/>
        <property type="gene ID" value="BLA_0438"/>
    </dbReference>
    <dbReference type="GeneID" id="66532823"/>
    <dbReference type="KEGG" id="bla:BLA_0438"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.468"/>
    <dbReference type="HOGENOM" id="CLU_050910_0_0_11"/>
    <dbReference type="OMA" id="PDPWHKS"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01057">
        <property type="entry name" value="tRNA_methyltr_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="PTHR23417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00091">
        <property type="entry name" value="TIGR00091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="260"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="281" mass="31200" checksum="006FA0F4AF5FC455" modified="2009-03-03" version="1">MTEQNRNLEESGNGGAANNPLHGRKVLSFVRRSARLDARLQRALDNYADEYILSDIALSEGSLDPCEGFVFSRDYVQGQWGNDNPLTVEIGSGQGENVVAAAAEHPERNFLALEVYDPGVAHTVLLAGKRGLRNLRVAQINAPELFAVMEPGVLDEVWTFFPDPWPKMRHHKRRIVQPELARDVHASLGVDGVWRIATDIEDYALHVHEVMDARRDFENLGTLTVSLPVEHVGKGNAESAAALPHADFMESERFDGRVLTNFEKKGLAAGRVIHDFAYRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWE9</accession>
    <name>B8DWE9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218199.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28800">
        <property type="protein sequence ID" value="ACL28800"/>
        <property type="gene ID" value="BLA_0501"/>
    </dbReference>
    <dbReference type="GeneID" id="61076259"/>
    <dbReference type="GeneID" id="66533632"/>
    <dbReference type="KEGG" id="bla:BLA_0501"/>
    <dbReference type="HOGENOM" id="CLU_2749635_0_0_11"/>
    <dbReference type="OMA" id="RIEEHQD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="70" mass="8246" checksum="F3A7DA3FBCFAAEB4" modified="2009-03-03" version="1">MVDMSDKMKENFEEIKARIDEHKDDFEDIKKSVGDLTDKLKDVKEGWETSRAEKGDKKEVAEHEETHQTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWG5</accession>
    <name>B8DWG5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Predicted integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">BLA_0517</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM175 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28816">
        <property type="protein sequence ID" value="ACL28816"/>
        <property type="gene ID" value="BLA_0517"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0517"/>
    <dbReference type="HOGENOM" id="CLU_1438498_0_0_11"/>
    <dbReference type="OMA" id="WMYSELT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010617">
        <property type="entry name" value="TMEM175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06736">
        <property type="entry name" value="TMEM175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="104"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACL28816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="194" mass="21344" checksum="D11CB7C70A13841B" modified="2009-03-03" version="1">MSKERVVAFTDAVLAIIMTILVLDLDKPDPLTWSGFGKLWPQFLAYAFSFFWLGSMWVHLHIEWSGVKLVDQPVLWTSITLLFFCSLIPYSTSLVAGNVLSWDLAIKIVGIMITLTIWPPAMLVFTLAAAMFLFLKSASAERRMQVKIKKDALANNGMATPDDVAAVGGSAEEYLAAIEAAKQAAKEADEGDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWG7</accession>
    <name>B8DWG7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">M-like protein Szp3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28818">
        <property type="protein sequence ID" value="ACL28818"/>
        <property type="gene ID" value="BLA_0519"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0519"/>
    <dbReference type="HOGENOM" id="CLU_1044538_0_0_11"/>
    <dbReference type="OMA" id="YQQANYQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="266" mass="28271" checksum="E83EFBCB19BEE7DA" modified="2009-03-03" version="1">MQQGYAPPSYQAPSYQQANYQPESGDGGKRRRRWPVVVAIITVVAIVGGVVGGIIYKNKHDEAYARCQTAVSEFSEARKALLDTTSDSPALQKLVRNALGVDKILDAAADAASAAEGTVAQQGCAANATIIQLNLVANTLNSATESLRKSTAQIVRGASADTDNTGDESESAASSDTEDVAQAKRNLQEAIDQGRALLDTLKQRYADSAVGRQLTAGFEAALDLAQEKFDESGIKDSRYYKAAQATLDEATNAVNAWIDRQAQKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWH5</accession>
    <name>B8DWH5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Possible XorII very-short-patch-repair endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">vsr</name>
        <name evidence="6" type="ordered locus">BLA_0527</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the Vsr family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28826">
        <property type="protein sequence ID" value="ACL28826"/>
        <property type="gene ID" value="BLA_0527"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0527"/>
    <dbReference type="HOGENOM" id="CLU_111913_1_0_11"/>
    <dbReference type="OMA" id="VEFWTAK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00221">
        <property type="entry name" value="Vsr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004603">
        <property type="entry name" value="DNA_mismatch_endonuc_vsr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03852">
        <property type="entry name" value="Vsr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00632">
        <property type="entry name" value="vsr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL28826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="164" mass="18769" checksum="1BB6F04AAD871460" modified="2009-03-03" version="1">MGTSADSGDSKYARGTRSYTMSRIRGKDTSIERLVRSYLFARGFRFRKNDRRYPGHPDIVLPKYHTIVFVNGCFWHMHEGCPKFKMPGSNVGFWTAKLTRNRERDGAQHEQLRAMGWRVIDVWECELERQSRDARLQSLASQILDAPVEGAVENGGETADTGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWH6</accession>
    <name>B8DWH6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218241.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28827">
        <property type="protein sequence ID" value="ACL28827"/>
        <property type="gene ID" value="BLA_0528"/>
    </dbReference>
    <dbReference type="GeneID" id="66533658"/>
    <dbReference type="KEGG" id="bla:BLA_0528"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.556"/>
    <dbReference type="HOGENOM" id="CLU_625095_0_0_11"/>
    <dbReference type="OMA" id="MFAYDAL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="522" mass="59245" checksum="01F526724761C37A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWJ5</accession>
    <name>RPOC_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit beta'</fullName>
            <shortName evidence="1">RNAP subunit beta'</shortName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RNA polymerase subunit beta'</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Transcriptase subunit beta'</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpoC</name>
        <name type="ordered locus">BLA_0547</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218268.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DWJ5"/>
    <dbReference type="SMR" id="B8DWJ5"/>
    <dbReference type="STRING" id="442563.BLA_0547"/>
    <dbReference type="PRIDE" id="B8DWJ5"/>
    <dbReference type="EnsemblBacteria" id="ACL28846">
        <property type="protein sequence ID" value="ACL28846"/>
        <property type="gene ID" value="BLA_0547"/>
    </dbReference>
    <dbReference type="GeneID" id="66533677"/>
    <dbReference type="KEGG" id="bla:BLA_0547"/>
    <dbReference type="HOGENOM" id="CLU_000524_3_1_11"/>
    <dbReference type="OMA" id="YRNIRVE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01322">
        <property type="entry name" value="RNApol_bact_RpoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012754">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02386">
        <property type="entry name" value="rpoC_TIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000214492" description="DNA-directed RNA polymerase subunit beta'">
        <location>
            <begin position="1"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1325"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1331"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="536"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="538"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="540"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="895"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="974"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="981"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="984"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="1345" mass="149448" checksum="F698DFD5136BC004" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWK9</accession>
    <name>B8DWK9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable transcriptional regulator with cyclic nucleotide-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_0563</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0563"/>
    <dbReference type="EnsemblBacteria" id="ACL28860">
        <property type="protein sequence ID" value="ACL28860"/>
        <property type="gene ID" value="BLA_0563"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0563"/>
    <dbReference type="HOGENOM" id="CLU_075053_3_2_11"/>
    <dbReference type="OMA" id="VLCRDFG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="3">
        <location>
            <begin position="35"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="4">
        <location>
            <begin position="172"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="253" mass="28459" checksum="4926F6C3234DDCEC" modified="2009-03-03" version="1">MNQSAERMPSGAMSDEPAGMGDARERRNPLLETALFKQVSEEQARELVPYLHHEEYDKGEYIFTEGDTDQRMYVIQEGRVKLTRQSVDKRVQLLSIHTRGELLGEIPVFDPQGGPRTANAVAMVDGTQVVWLDHDALFAWLSKYPGVAVDMLQVLANRMRANNERIADLVFSDVPGRLAKTLLSLASRFGKPVEEGLQVPHDLTQEEMAQLVGSSRETVNKALMDFANRGWIARNGRTIIIYQPGALIRRSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWM6</accession>
    <name>B8DWM6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0580"/>
    <dbReference type="EnsemblBacteria" id="ACL28877">
        <property type="protein sequence ID" value="ACL28877"/>
        <property type="gene ID" value="BLA_0580"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0580"/>
    <dbReference type="HOGENOM" id="CLU_020572_0_0_11"/>
    <dbReference type="OMA" id="KRIRWWG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025101">
        <property type="entry name" value="DUF4012"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13196">
        <property type="entry name" value="DUF4012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="558" mass="61657" checksum="6B4197A2F34AFE7B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWM9</accession>
    <name>B8DWM9_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="4 6">4.2.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rfbB</name>
        <name evidence="8" type="ordered locus">BLA_0583</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:17221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="EC" id="4.2.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="4 6"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0583"/>
    <dbReference type="EnsemblBacteria" id="ACL28880">
        <property type="protein sequence ID" value="ACL28880"/>
        <property type="gene ID" value="BLA_0583"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0583"/>
    <dbReference type="HOGENOM" id="CLU_007383_1_14_11"/>
    <dbReference type="OMA" id="EWCQHVQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="7">
        <location>
            <begin position="19"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="347" mass="39317" checksum="9973913B1A75BE28" modified="2009-03-03" version="1">MVVAKLMPMTDAFIPKNIIVTGGCGFIGSNFVHYVYNNHPDVHITVLDALTYAGNLENIKPILGDRVEFVHGNICDAQLLDELVPGHDAIVHYAAESHNDNSIANPEPFVKTNVEGTFRLLEAARKYDVRFHHISTDEVYGDLALDDPAKFTEETPYHPSSPYSSTKASSDMLVRAWHRTYGLRTTISNCSNNYGPYQHVEKFIPRQITNIIEGIRPKLYGDGLNVRDWIHTEDHSSAVWTILTTGRLGETYLIGANGERNNLTVLHDILRVMGQPEDAFDWVKDRPGHDRRYAIDSTKLQTELGWRPTHTDFESGLRQTVQWYIDNPQWWEPAKAATEAKYKAQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWQ5</accession>
    <name>B8DWQ5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218350.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28906">
        <property type="protein sequence ID" value="ACL28906"/>
        <property type="gene ID" value="BLA_0613"/>
    </dbReference>
    <dbReference type="GeneID" id="66533744"/>
    <dbReference type="KEGG" id="bla:BLA_0613"/>
    <dbReference type="HOGENOM" id="CLU_085284_0_0_11"/>
    <dbReference type="OMA" id="NDEAYAV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="284" mass="31134" checksum="8D4C4E7F09AD30B6" modified="2009-03-03" version="1">MFNGKKKAPKNDWRQSIMSLGQVKNEANESESQTTRRMPFGRTGRTDRPQSQHMPTATMPNGPATGMQVAAQAAPPQKRKRFKVLIYAFAFLMVFALGVGAGSSNASKPAGTVPSAAVAPTEQIDAKENDAELKRREEALNKQAEELDKLKRELDEQQKSQSERQTQLDEREKSIASKEEAKKQAEVEAAQRKKAEQEQAAAAEKARAEAEAAERERAQAQAAQAAAEEAARQQEQAPQVVEQQTSRIVHPGAFCSTAGETGVSQKGVGYTCKADNSGRLRWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWR7</accession>
    <name>B8DWR7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619785.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0625"/>
    <dbReference type="EnsemblBacteria" id="ACL28918">
        <property type="protein sequence ID" value="ACL28918"/>
        <property type="gene ID" value="BLA_0625"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0625"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.655"/>
    <dbReference type="HOGENOM" id="CLU_066817_0_0_11"/>
    <dbReference type="OMA" id="INSEWTR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870851" evidence="1">
        <location>
            <begin position="26"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="336" mass="36474" checksum="387B89E5A4B98DA8" modified="2009-03-03" version="1">MNTRRKAVSLGAAGLALCMCVTLGACEGQLPEPVQATASASASPNLTTEQEKAIRKQLLEVIEQCNNAKSADGLDRAMSGPELEIRRSELAVAQKTGNLDPKTDIPDAITQTIIPTDSGWPRSVFTITTTTQDQQSKRLLVFDQESARQNYKLWGVARLFQGVQMPKFTVPQIGAQMGTDNDDNLKMTPKEAVKRYADVLQNGDKSQYAGDFDNDYLRQELATLSQTVQQGMERNKGTQTQTFEPVDGQMRIMRAADGGDLVVAQINSVWTRAAGEGRESQPASDSEKALFGDAKATSTMRVTYVNVVALYIPSAKANAKITAVGAERQPVKVEAI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWS2</accession>
    <name>ATPB_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase subunit beta</fullName>
            <ecNumber evidence="1">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F1 sector subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-ATPase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpD</name>
        <name type="ordered locus">BLA_0630</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219179.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DWS2"/>
    <dbReference type="SMR" id="B8DWS2"/>
    <dbReference type="STRING" id="442563.BLA_0630"/>
    <dbReference type="PRIDE" id="B8DWS2"/>
    <dbReference type="EnsemblBacteria" id="ACL28923">
        <property type="protein sequence ID" value="ACL28923"/>
        <property type="gene ID" value="BLA_0630"/>
    </dbReference>
    <dbReference type="GeneID" id="66533761"/>
    <dbReference type="KEGG" id="bla:BLA_0630"/>
    <dbReference type="HOGENOM" id="CLU_022398_0_2_11"/>
    <dbReference type="OMA" id="GFNMIMD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0139">CF(1)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000166572" description="ATP synthase subunit beta">
        <location>
            <begin position="1"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="178"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01347"/>
        </source>
    </evidence>
    <sequence length="495" mass="54090" checksum="5E5F511C062469C1" modified="2009-03-03" version="1">MAENQANAAADEAAEPIVGHVTRIQGSVIDVEFPVGHMPDIYNALTVEIKQMGQQEEGEVKDSVITLEVEQHLGDSTARCVALKSTDGLVRGAIVHDTGGPIEVPVGDVTKGHVFDVSGHILNKKPGEKIVIKERWPIHRNPPAFDQLESKTQMFETGIKVIDLLTPYVQGGKIGLFGGAGVGKTVLIQEMIQRVAQNHGGVSVFAGVGERTREGNDLIGEMDEAGVLEKTALVFGQMDEQPGTRLRVPLTALTMAEYFRDVQNQDVLLFIDNIFRFTQAGSEVSTLLGRMPSAVGYQPNLADEMGSLQERITSTRGHSITSLQAIYVPADDYTDPAPATTFAHLDATTELSRDIASRGIYPAVDPLASTSRILDPRYVGQAHYDCANRVKAILQRNKELQDIIALIGIDELGEEDKTTVNRARKIEQFLGQNFYVAEKFTGVPGSYVPAEETIEAFTRICDGVYDNVPEQAFSGIGGIEDLEKKWHKMQKEYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWT2</accession>
    <name>B8DWT2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28933">
        <property type="protein sequence ID" value="ACL28933"/>
        <property type="gene ID" value="BLA_0640"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0640"/>
    <dbReference type="HOGENOM" id="CLU_780028_0_0_11"/>
    <dbReference type="OMA" id="AGYCENA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="381" mass="43893" checksum="CE10FC99CAA32A6A" modified="2009-03-03" version="1">MKKDTAEVSMEIDSKMLVASLRNYAEAKHMQLQDVGKQLGFSKDRTKSIFTGRSKLTGDDVLRILMNVDIPLPELKRYRQLWRLRREVLNFERPDDFEQFVDGLNVSATLFPRKVQGSLARSDNERVSTELARDMMARENWYVLRNGWVCALKVEGKWVTFTPFAPDFMTAARAMIGLKWIHRKTETSIPFIDWGAVRGGCPSSEETSRFVGRELLKYIQSKPDRFPLDDEFRGMVAGKAMGEFQQNRILELEKSLNTVKEIAESSLKYSLSTEKDEYGISPAEIYSSVFDYLESNVTNLYGIRRLLLEDGITIPPQLEEECERVLGLNERHYKYSLYIEPILAVNDLPDRLASPTKAERVQYEKLRADSEEKSKKSKSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSJ0</accession>
    <name>B8DSJ0_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">clpB</name>
        <name evidence="14" type="ordered locus">BLA_0676</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer; The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0676"/>
    <dbReference type="EnsemblBacteria" id="ACL28969">
        <property type="protein sequence ID" value="ACL28969"/>
        <property type="gene ID" value="BLA_0676"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0676"/>
    <dbReference type="HOGENOM" id="CLU_005070_4_2_11"/>
    <dbReference type="OMA" id="SKMMQGE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
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        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
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        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="13">
        <location>
            <begin position="5"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="864"/>
            <end position="899"/>
        </location>
    </feature>
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        <location>
            <begin position="403"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="884"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACL28969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="899" mass="98635" checksum="318D91F291075EC9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSJ8</accession>
    <name>B8DSJ8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269237.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0684"/>
    <dbReference type="EnsemblBacteria" id="ACL28977">
        <property type="protein sequence ID" value="ACL28977"/>
        <property type="gene ID" value="BLA_0684"/>
    </dbReference>
    <dbReference type="GeneID" id="66533817"/>
    <dbReference type="KEGG" id="bla:BLA_0684"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.713"/>
    <dbReference type="HOGENOM" id="CLU_054156_0_0_11"/>
    <dbReference type="OMA" id="MQEQSMH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022603">
        <property type="entry name" value="DUF3152"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11350">
        <property type="entry name" value="DUF3152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3152" evidence="2">
        <location>
            <begin position="154"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="303" mass="34037" checksum="214D38F4EBE150CA" modified="2009-03-03" version="1">MTGSHKQNSIRSSRQSSPRRKRRLPKRVYIMRRVVVLLVTVLWIVFVWLSVAGEARALFQARNLQASSNAGAASRWKPTHFHDAQIERANTERSESAEHSENTHAEQDAQAIAALEAPLSDEQRHEILDKARQAAYEDNKTPVVLHYCVATNGNVGSAEGFANTVFRVLNNPQGWPRAGVIFAPTHDTNACEFTIMLAESSKLAEYSQGCSAEYSCRVGTDVIINKKRWDEAVEHWFAHGETLSQYRTMVLNHEVGHVLGHVDNETVCEGEGKRAPLMQEQSMDLRGCTPNAWPLDNELWTAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSK6</accession>
    <name>B8DSK6_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpsF</name>
        <name evidence="6" type="ordered locus">BLA_0692</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds together with S18 to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219090.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0692"/>
    <dbReference type="EnsemblBacteria" id="ACL28985">
        <property type="protein sequence ID" value="ACL28985"/>
        <property type="gene ID" value="BLA_0692"/>
    </dbReference>
    <dbReference type="GeneID" id="66533825"/>
    <dbReference type="KEGG" id="bla:BLA_0692"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.721"/>
    <dbReference type="HOGENOM" id="CLU_113441_5_3_11"/>
    <dbReference type="OMA" id="ITEASPM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00473">
        <property type="entry name" value="bS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00360">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020814">
        <property type="entry name" value="Ribosomal_S6_plastid/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_S6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="PTHR21011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="SSF54995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL28985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="95" mass="10885" checksum="E3E0300F44C779D6" modified="2009-03-03" version="1">MSAHNYELMFIADPELDENGLKKLTNQHMEIVTKEGGSVENIDIWGRRKLAYEIDGKTEGNYVVVTYSCEPATNDELDRVLNLNESIVRTKILRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSP2</accession>
    <name>B8DSP2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable prephenate dehydrogenase</fullName>
            <ecNumber evidence="3">1.3.1.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tyrA</name>
        <name evidence="3" type="ordered locus">BLA_0728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.1.12" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218709.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0728"/>
    <dbReference type="EnsemblBacteria" id="ACL29021">
        <property type="protein sequence ID" value="ACL29021"/>
        <property type="gene ID" value="BLA_0728"/>
    </dbReference>
    <dbReference type="GeneID" id="66533489"/>
    <dbReference type="KEGG" id="bla:BLA_0728"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.759"/>
    <dbReference type="HOGENOM" id="CLU_055968_1_0_11"/>
    <dbReference type="OMA" id="MWRDICL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="2">
        <location>
            <begin position="28"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="364" mass="40577" checksum="E3A8C226B0F4BDC5" modified="2009-03-03" version="1">MHEETIKQWDRDNAGEPQIAPEGIECPKHVAIVGLGLIGGSLARRLRESGCHVSAWNHRDHPYANARAAGIDCKDTLEELVAEEPDVLMLCNPLVAMPQVLQTIKPIINPQKTTLSDVGSVKGPVRTQVSEVGLLDCYVGAHPMAGNEHSGWVAADPTLFDDALWAVTFGLHTQYRRVVQIAGMITRGVRNTMIVIDDVTHDREASLISHMPHVLSTALINEMTSDANNAIASALSAGSWRDMTRVALTDPDRTRAMVVENAHNVEELLHRMIDWLSEFANALHEEDETEIRHFFAEGQPYRDYKAQINAGKVSDSTETIFQSLRIDPEHWREQLLKSAQRGEYIVRFTSGHRLIAEQHPSIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSP6</accession>
    <name>B8DSP6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BLA_0732</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0732"/>
    <dbReference type="EnsemblBacteria" id="ACL29025">
        <property type="protein sequence ID" value="ACL29025"/>
        <property type="gene ID" value="BLA_0732"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0732"/>
    <dbReference type="HOGENOM" id="CLU_001265_46_6_11"/>
    <dbReference type="OMA" id="EIFPTKD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="50"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="469" mass="50503" checksum="DC175489CA3DB662" modified="2009-03-03" version="1">MTTAELGLGAATPIDGPSPEREPLANAEATTLTRNERLDRLPFNKAHRKLLMASGIGWAFDAMDVGLVSFVVTAIAADPHFNLDATQKSWVLSIGFIGMAIGAALGGFLADKLGRKTVFTATMIVFGLANGAMAFSWTLLALLAARFVIGLGLGAELPVASTLVSEFSPAKQRGRITVLLESFWAVGWILAAMIGYFVIPNTGDWGWRWALLIGAIPLLYAIVARRHLPESVRFLEARGDNERAEASVRYFEQASGVAAVPSKPARKLGRIRMRELVGRKYLGITLAIWATWFFVNFSYYGAFTWMPSLLADQFGSLTKSFGYTLAISIAQLPGYFLAAFLVERWGRRKTLSVFLAVSALAAFLFSQSATVAQVLCFGMLLSASNLGAWGVMYAVTPEIYPTRMRSTAAGAAAAVGRIAAIVAPLLVPWFLTMSGGNKSVAFIVFAVAFVLACVAALFLPERTGESLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSR0</accession>
    <name>B8DSR0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase</fullName>
            <ecNumber evidence="5">6.3.2.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">murE</name>
        <name evidence="5" type="ordered locus">BLA_0746</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurCDEF family. MurE subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.13" evidence="5"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218689.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0746"/>
    <dbReference type="EnsemblBacteria" id="ACL29039">
        <property type="protein sequence ID" value="ACL29039"/>
        <property type="gene ID" value="BLA_0746"/>
    </dbReference>
    <dbReference type="GeneID" id="66533507"/>
    <dbReference type="KEGG" id="bla:BLA_0746"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.777"/>
    <dbReference type="HOGENOM" id="CLU_022291_4_2_11"/>
    <dbReference type="OMA" id="CFMEVSS"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008765">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005761">
        <property type="entry name" value="UDP-N-AcMur-Glu-dNH2Pim_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01085">
        <property type="entry name" value="murE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="4">
        <location>
            <begin position="123"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="3">
        <location>
            <begin position="354"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="516" mass="56969" checksum="1A07B5E1C0B6AC12" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSS8</accession>
    <name>B8DSS8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218662.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29057">
        <property type="protein sequence ID" value="ACL29057"/>
        <property type="gene ID" value="BLA_0764"/>
    </dbReference>
    <dbReference type="GeneID" id="66533526"/>
    <dbReference type="KEGG" id="bla:BLA_0764"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.796"/>
    <dbReference type="HOGENOM" id="CLU_2434918_0_0_11"/>
    <dbReference type="OMA" id="PPHKERH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="90" mass="10393" checksum="323A3E1641725CDB" modified="2009-03-03" version="1">MNQQPHADIDYDPNADTILSAHDWAINTDMTVTEYATNIQAFRNETLQDWEATTPDELRHMADHIRHDYADTLDAIANQWEQHNQGDTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>B8DST0</accession>
    <name>B8DST0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218660.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29059">
        <property type="protein sequence ID" value="ACL29059"/>
        <property type="gene ID" value="BLA_0766"/>
    </dbReference>
    <dbReference type="GeneID" id="66533528"/>
    <dbReference type="KEGG" id="bla:BLA_0766"/>
    <dbReference type="HOGENOM" id="CLU_2614898_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="78" mass="8671" checksum="C989E115893E5DA2" modified="2009-03-03" version="1">MGKPQEQPDMIHTGDTHYEQARAHRIAHDLLTAAAQALMHGTPPHYPRLNRADPYSDAVTATILHQLATTTTTTKEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSU5</accession>
    <name>B8DSU5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidoglycan synthetase</fullName>
            <ecNumber evidence="5">2.4.1.129</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsI</name>
        <name evidence="5" type="ordered locus">BLA_0782</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.129" evidence="5"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218641.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0782"/>
    <dbReference type="EnsemblBacteria" id="ACL29074">
        <property type="protein sequence ID" value="ACL29074"/>
        <property type="gene ID" value="BLA_0782"/>
    </dbReference>
    <dbReference type="GeneID" id="66533544"/>
    <dbReference type="KEGG" id="bla:BLA_0782"/>
    <dbReference type="HOGENOM" id="CLU_009289_6_5_11"/>
    <dbReference type="OMA" id="HGKEEYY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="4">
        <location>
            <begin position="62"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="3">
        <location>
            <begin position="277"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="598" mass="63990" checksum="F67418AA2BEC420B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSX4</accession>
    <name>B8DSX4_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">ftsZ</name>
        <name evidence="11" type="ordered locus">BLA_0811</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="6">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the FtsZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218598.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0811"/>
    <dbReference type="EnsemblBacteria" id="ACL29103">
        <property type="protein sequence ID" value="ACL29103"/>
        <property type="gene ID" value="BLA_0811"/>
    </dbReference>
    <dbReference type="GeneID" id="66533573"/>
    <dbReference type="KEGG" id="bla:BLA_0811"/>
    <dbReference type="HOGENOM" id="CLU_024865_2_2_11"/>
    <dbReference type="OMA" id="GNPSIGQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 6 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="9">
        <location>
            <begin position="15"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="10">
        <location>
            <begin position="209"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="334"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="334"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="23"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="110"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL29103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="418" mass="43435" checksum="92CB11349D7C5DC6" modified="2009-03-03" version="1">MSEIAQTDNFNDTTIIKVVGVGGAGGNAVNRMIAEGLQNVEFVAINTDAKDLLRSDADVKISLSDASSRGLGAGADPEKGAKAAQDHQSEIEEAVKGADMVFVTCGEGGGTGTGASPLVARAARQQGALTIAVVTRPFSFEGPQRAASAALGIDNLREEVDALIVIPNDRLLELDDSSIGIVDAFRTADTALLAGVQGITDLLTINPYIHVDFSDITSILQNSGTALFGIGAARGEDRAAQAAEIAISSPLLEESIDGASGVLINIAASNDLKLAEVNQAVGFVREAAHPEAQIIFGLALDDAYGDEMRVTVIAAGFNDKKKLAQANEDAQAAASAPQRTVKPVTKTATASGQPTILTSPIPSTGPVFEEEKKTDEKIVAQQPTPKQRSEYDASSDTSSYPYTALGDLGDLDIPEFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSY3</accession>
    <name>B8DSY3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Possible permease protein of ABC transporter system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_0820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269208.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0820"/>
    <dbReference type="EnsemblBacteria" id="ACL29112">
        <property type="protein sequence ID" value="ACL29112"/>
        <property type="gene ID" value="BLA_0820"/>
    </dbReference>
    <dbReference type="GeneID" id="66533582"/>
    <dbReference type="KEGG" id="bla:BLA_0820"/>
    <dbReference type="HOGENOM" id="CLU_046113_2_1_11"/>
    <dbReference type="OMA" id="LDIPRMF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="70"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="270" mass="29303" checksum="E584B9CC3F454747" modified="2009-03-03" version="1">MAFHSSLRNHTDRPRRQAWRHWPTVVTVVALLLIWQVWVDAAHPPVTMVSSPTQIVRSAIISWPTLWPATCMTFIEGVCGFAIACVLGVLLGIGIHCSRTAYAALFPLLTAAQTLPLISIAPLFLIWFGFEPVGKIVIVAVFAIFPIVVQTMRGLAAVPAFYDDVAMTCGASRAWTLFHVDLRVAARQIFGGVRVSAAYVFATAATAEYLGARSGLGIWLQAAYNSFQTPRIFAATFVIIIMTGLLLLAVHAVERLTIGAPADDDDPDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT06</accession>
    <name>B8DT06_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable solute-binding protein for glutamate/aspartate ABC transporter system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_0843</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218550.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0843"/>
    <dbReference type="EnsemblBacteria" id="ACL29135">
        <property type="protein sequence ID" value="ACL29135"/>
        <property type="gene ID" value="BLA_0843"/>
    </dbReference>
    <dbReference type="GeneID" id="66533605"/>
    <dbReference type="KEGG" id="bla:BLA_0843"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.878"/>
    <dbReference type="HOGENOM" id="CLU_019602_18_4_11"/>
    <dbReference type="OMA" id="FDKSEPY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870470" evidence="3">
        <location>
            <begin position="27"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="4">
        <location>
            <begin position="64"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="302" mass="32331" checksum="23D952D93A4FDD55" modified="2009-03-03" version="1">MSSLFKQLGKAVAAAGAAVMMITAVAACGPSASTPSEAGSASGNTQNSTNAKARTLDEIKKSGELRVAVFSDKAPFGYVDKDGKYAGYDIEFAQALADGLGVKPVYTSVDPAARVDVLASNKVDVTLANFTETPERAEKVDFSKPYMKVALGIVAPDAAPIKDVKDLNGKTLIVAKGTTAETYFEKNHPEIKLQKYDQYADAYNALLDGRGDAMSTDNTEVLAWAKANKGYRVDVTEIGDVDVIAAAVQKGNKELLDYINDEIVKLGKENFFHKDFEKTLKPVYGDEVNPDDIVVESGVIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT27</accession>
    <name>B8DT27_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0864"/>
    <dbReference type="EnsemblBacteria" id="ACL29156">
        <property type="protein sequence ID" value="ACL29156"/>
        <property type="gene ID" value="BLA_0864"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0864"/>
    <dbReference type="HOGENOM" id="CLU_062186_0_1_11"/>
    <dbReference type="OMA" id="CAGKMKK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="304" mass="34380" checksum="B9CDBCC529222308" modified="2009-03-03" version="1">MPGLAPGIEPDGVVHHTVMADGTHMNGWCLLVAIDGEDGEVLAWQWCDRESAAAYKALSEQIAPPDVLICDGMKGIGKACAEAWPGTRIQRRLIHVQRDTRADLTSRPRLEAGRELKGPADAPARIHDPEHAARWGEAPDAWHERWKTMLAERTFAKDHPDDPRAATSTSGWWWTHLPLRRAYPRLERLFRNGTLFCFLDPELLEHGPVARDSNRLEGGVNAKLKLMLPNHRGLPPKHMRRACEWHCHMKSNDPDPTRILKEHDRKSKTKQAAPQENDMPQPTLGTGIDWNEFHTSTRYPNSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT30</accession>
    <name>B8DT30_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29159">
        <property type="protein sequence ID" value="ACL29159"/>
        <property type="gene ID" value="BLA_0867"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0867"/>
    <dbReference type="HOGENOM" id="CLU_1188074_0_0_11"/>
    <dbReference type="OMA" id="SGLDQMF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="232" mass="26771" checksum="0A8516F0DCA14DAF" modified="2009-03-03" version="1">MLMIRENDLETVLANRRNFIGIAPRLESALTIITGVFYVASAVVMEDLWWKIPMYVLGAIVTIYGIAGVIRKPYTTKQLFKEIAGMNAIASSIIAITEPGISDSNKYLVYWDTKWKCWFFPNRRSTPSVPDDERDLRNYLHAEFKVPQDDCTLEYKTDGESTKYSTEHDEMRYYDYRIYRGVVSALPDSWSVDGPFDVGGHRCKWMTIDEMLADEETDRINHDVIVLVRDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT32</accession>
    <name>B8DT32_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein possibly involved in ATP-driven polysaccharide export</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rgpDc</name>
        <name evidence="7" type="ordered locus">BLA_0869</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0869"/>
    <dbReference type="EnsemblBacteria" id="ACL29161">
        <property type="protein sequence ID" value="ACL29161"/>
        <property type="gene ID" value="BLA_0869"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0869"/>
    <dbReference type="HOGENOM" id="CLU_000604_101_6_11"/>
    <dbReference type="OMA" id="KMAFLNW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="26"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="63"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="448" mass="49953" checksum="ED3114D94D2F1A95" modified="2009-03-03" version="1">MDKPVVLDVEHVDKWFKLPTEQATGLKQAFINWTKGIKGFKKQQVLKDVTFQVHQGEFFGIVGRNGGGKSTLLKIISQIYYPNRGSVNVTGKLVPFIELGVGFNPELTGRENVYLNGALLGFTPEEVDAMYDDIVEFAELGEFMDQKLKNYSSGMQVRLAFSVAIKAQGDILVLDEVLAVGDEAFQRKCDDYFTKVRQDPTKTVILVTHDMSAIKRYCTRAMFIKDGEVAAIGDRETVSESYTLANLEAIDQENEEKARKALEAGHEEYPNGLNERCPLLRTYGVSPLMLTSADTFRFAVEYQFDETDDFYLAIALHDVRRGGITFDTGARNPQMHMTKPGHHTVYFEMPLDLFNNGEFRLITSLRTPTPGDGKMTDAVAVALDDNACTFAIRDPRNSNYALINNRALYIKPISEEEAEDAAAEQKAARKETADTAADANTVFESGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT41</accession>
    <name>B8DT41_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine amidotransferase, class-II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269244.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0878"/>
    <dbReference type="EnsemblBacteria" id="ACL29170">
        <property type="protein sequence ID" value="ACL29170"/>
        <property type="gene ID" value="BLA_0878"/>
    </dbReference>
    <dbReference type="GeneID" id="66533857"/>
    <dbReference type="KEGG" id="bla:BLA_0878"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.918"/>
    <dbReference type="HOGENOM" id="CLU_078990_0_0_11"/>
    <dbReference type="OMA" id="GYEQEGW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="289" mass="31400" checksum="7CC69AA85360732E" modified="2009-03-03" version="1">MCRLLGYATANENISLREVLGAQSTDAFRELSEIHNDGWGTAMVKEPDQTAHVTDGGAPSPSTGSAIYRNTIAARYDSIFGDLASVPVRGGIWHLRLASSNLPLVLENQQPFYASGLSFIHNGDISDAQGRNITTNRAYPVDHTLVQSTGGRSDSAIYFAIVLQYLGYGYELEEALAQAVRELRGAYPDSSYNCIIQSRDQLIVLEAHDNGPTQQDVLDVYAQYGRAAEAADYRTVRYREITGADGARKGVVAASSGFAQPADEGWKDLGNNRMIVASNRTGAFRVRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT73</accession>
    <name>B8DT73_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Permease of ABC transporter possibly for oligosaccharides</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_0910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269248.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0910"/>
    <dbReference type="EnsemblBacteria" id="ACL29202">
        <property type="protein sequence ID" value="ACL29202"/>
        <property type="gene ID" value="BLA_0910"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0910"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.953"/>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_11"/>
    <dbReference type="OMA" id="EYAIFFR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="72"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="278" mass="30947" checksum="92086C0351F297ED" modified="2009-03-03" version="1">MQEKPKHGALWTIFFSMISIAWVFPIFLVLLNSFKGKAYISRNAFAFPVGDTFVGLENYKRGIESTNFFASFGWTVLITVGSVCLILVCTSMCAWWIVRVNNWAAKLLYTLFLFNMIVPFQMVMFTLSKLADMLKLNTPWGLCFIYLGFGAGLAVFIFTGVVKGIPQSLEESAMIDGASVPRIFFQVVVPIMKPSIVSVAILEAMWVWNDYLLPYLTLDLGKYKTISVAVQYLKGGYGSVDMGAMMACLVLAIIPIIVFYLICQKYIVKGVMAGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT89</accession>
    <name>B8DT89_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RelA/SpoT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">relA</name>
        <name evidence="3" type="synonym">spoT</name>
        <name evidence="3" type="ordered locus">BLA_0926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0926"/>
    <dbReference type="EnsemblBacteria" id="ACL29218">
        <property type="protein sequence ID" value="ACL29218"/>
        <property type="gene ID" value="BLA_0926"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0926"/>
    <dbReference type="HOGENOM" id="CLU_077095_0_0_11"/>
    <dbReference type="OMA" id="VWATIEH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RelA_SpoT" evidence="2">
        <location>
            <begin position="82"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="262" mass="29758" checksum="94D312FD3BCFA1B8" modified="2009-03-03" version="1">MILDRQKRMNTAEIRARLTAAGHSLGLDGTEEGERGVDLITDFINQMQIYEGAMYEISTKLEILDSEFQVQFSHNPIHHLERRLKSTESILGKLDRRGLPYTVEAIRDNLFDVAGIRVICNYRDDVYSVANYLSAQSDIQVLRVKDYIRNPKQNGYRSLHVIYAVPVFLSSGAHYTPVEVQFRTIAMDYWASLEHALRYKTDLPDDKHAEHSQTLLDCARALQNVETQMQTIHRDINGAPQGGEAPTANEDSPIRNATLKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT94</accession>
    <name>B8DT94_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CinA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0931"/>
    <dbReference type="EnsemblBacteria" id="ACL29223">
        <property type="protein sequence ID" value="ACL29223"/>
        <property type="gene ID" value="BLA_0931"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0931"/>
    <dbReference type="HOGENOM" id="CLU_030805_1_0_11"/>
    <dbReference type="OMA" id="VEHALNM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA" evidence="1">
        <location>
            <begin position="13"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="193" mass="20805" checksum="1C27027F2F1EF58C" modified="2009-03-03" version="1">MADVQRYCDEQARHILAHCDVRGLKIACAESLTAGLLADSFVRIPGASSVFLGSAVTYDIHAKAMVLGVDAELLRTHGAVDPEVARQMARGAAHLFYQEQYAHGVVGLSTTGVAGPGPDEGKPAGTVYIGFDVPCFSHSVIQERDFALRLALRGSRELVRHLTVACVLGKMREFTGSSQEKIPIMETRETHEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTB1</accession>
    <name>B8DTB1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent helicase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">lhr</name>
        <name evidence="4" type="ordered locus">BLA_0950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619884.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0950"/>
    <dbReference type="EnsemblBacteria" id="ACL29240">
        <property type="protein sequence ID" value="ACL29240"/>
        <property type="gene ID" value="BLA_0950"/>
    </dbReference>
    <dbReference type="GeneID" id="66533437"/>
    <dbReference type="KEGG" id="bla:BLA_0950"/>
    <dbReference type="HOGENOM" id="CLU_002025_3_1_11"/>
    <dbReference type="OMA" id="LPFWHGD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="31"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="335"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="1557" mass="168876" checksum="66B7029AB8D9D98E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTB8</accession>
    <name>B8DTB8_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="4">dUTPase</shortName>
            <ecNumber evidence="4">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">dut</name>
        <name evidence="6" type="ordered locus">BLA_0957</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>dUTP + H2O = diphosphate + dUMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="4"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0957"/>
    <dbReference type="EnsemblBacteria" id="ACL29247">
        <property type="protein sequence ID" value="ACL29247"/>
        <property type="gene ID" value="BLA_0957"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0957"/>
    <dbReference type="HOGENOM" id="CLU_068508_1_3_11"/>
    <dbReference type="OMA" id="YAAFVHP"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00116">
        <property type="entry name" value="dUTPase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="PTHR11241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="5">
        <location>
            <begin position="29"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="74"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="91"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="155" mass="16490" checksum="F97ABB340E8CB784" modified="2009-03-03" version="1">MFDEAYVEPERTEVLVAPVNPAQPVELHYMHAGDAGADLVTTAHVELGPFQRALVPTGVRIALPAGYVGLVHPRSGLAVKQGVTVLNAPGTIDAGYRGEIKVPLINLDPEHTAVFEPGDRIAQLVIQRYVQAEFIEASVLPGSDRAERGFGSSGV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTD1</accession>
    <name>TIG_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trigger factor</fullName>
            <shortName evidence="1">TF</shortName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">PPIase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tig</name>
        <name type="ordered locus">BLA_0970</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FKBP-type PPIase family. Tig subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619893.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DTD1"/>
    <dbReference type="SMR" id="B8DTD1"/>
    <dbReference type="STRING" id="442563.BLA_0970"/>
    <dbReference type="EnsemblBacteria" id="ACL29260">
        <property type="protein sequence ID" value="ACL29260"/>
        <property type="gene ID" value="BLA_0970"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0970"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1013"/>
    <dbReference type="HOGENOM" id="CLU_033058_3_0_11"/>
    <dbReference type="OMA" id="KGIKTQF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00303">
        <property type="entry name" value="Trigger_factor_Tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005215">
        <property type="entry name" value="Trig_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008880">
        <property type="entry name" value="Trigger_fac_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037041">
        <property type="entry name" value="Trigger_fac_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008881">
        <property type="entry name" value="Trigger_fac_ribosome-bd_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036611">
        <property type="entry name" value="Trigger_fac_ribosome-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560">
        <property type="entry name" value="PTHR30560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05698">
        <property type="entry name" value="Trigger_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05697">
        <property type="entry name" value="Trigger_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003095">
        <property type="entry name" value="Trigger_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102735">
        <property type="entry name" value="SSF102735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00115">
        <property type="entry name" value="tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0697">Rotamase</keyword>
    <feature type="chain" id="PRO_1000198143" description="Trigger factor">
        <location>
            <begin position="1"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="1">
        <location>
            <begin position="166"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00303"/>
        </source>
    </evidence>
    <sequence length="461" mass="50081" checksum="576ADA92622E1B58" modified="2009-03-03" version="1">MKISVRNLEPTKAKLTITVDQDEFDPYLEDARKEIAEQITVPGFRKGHVPGKLVDQRVGFGAVAGEAVNKALPDMYAKALDEKDIRPMDQPQIEVVEMPQSAADDTKLKFTATVERRPEFELPNLEGLEIAVDKAEVSDDDVNNRLGTLRQRFATLVGVDRPAQKGDFANIDLTAQTDGETVDSQEGVSYEIGSGTMLDGLDEALEGLSAGEETTFESTLEGGDHEGEKAQVKVKVNSVKAEELPELDDDFAQEASEFDTLDELKAEIRKNIEADAEGRQATIARDAFIETLEEGLDIPLPKGVRNNMVEQQLKSMGVEAGKATSDQKKEAEEAVDKMLKDQMVLDALAEKLDVQVSQSDVFNFLGSIAQQYGMDPNMFIQALMRNGQIGSARREVARSRACSPGCVRWKFTVDGEPLDLSGFLGSEEAEAQAEEDESVAAAAAAAAVADNLTSDDGTDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTE5</accession>
    <name>B8DTE5_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal kinase</fullName>
            <ecNumber evidence="1">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.35" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217655.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0984"/>
    <dbReference type="EnsemblBacteria" id="ACL29274">
        <property type="protein sequence ID" value="ACL29274"/>
        <property type="gene ID" value="BLA_0984"/>
    </dbReference>
    <dbReference type="GeneID" id="66533403"/>
    <dbReference type="KEGG" id="bla:BLA_0984"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1027"/>
    <dbReference type="HOGENOM" id="CLU_046496_2_0_11"/>
    <dbReference type="OMA" id="AIHDISC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PTHR10534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="2">
        <location>
            <begin position="36"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="289" mass="31495" checksum="C30AD47A486EC574" modified="2009-03-03" version="1">MPEVLYERNREYIPRIAAVHDMCGYGKCSLTAAIPILSAAGCDVCPVPTALFSAHTRYKVFTMEDTTDMLGGYLDAWQQEGVELDGVYSGFLGSPDQVAIIQRLYREYPKSLRFVDPVMGDAGEMYATYTAQLCEAMGALVDGADLLMPNLTESSILTGTEYPGQDITNEQVRQIIGNLFDMGAKNVVLKGIDHNDGRIRNFVANAKEGVDRMTECVHEKLPYMCHGTGDAFASAMIGGVMAGLDLAAASRLAGEFVHNAMVQTKFQPDYQDRGVSFELSLGDLTSLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTE6</accession>
    <name>B8DTE6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-acetylhomoserine (Thiol)-lyase</fullName>
            <ecNumber evidence="5">2.5.1.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cysD</name>
        <name evidence="5" type="ordered locus">BLA_0985</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.49" evidence="5"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619897.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0985"/>
    <dbReference type="EnsemblBacteria" id="ACL29275">
        <property type="protein sequence ID" value="ACL29275"/>
        <property type="gene ID" value="BLA_0985"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0985"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1028"/>
    <dbReference type="HOGENOM" id="CLU_018986_4_0_11"/>
    <dbReference type="OMA" id="TYTLFAH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003961">
        <property type="term" value="F:O-acetylhomoserine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="440" mass="47809" checksum="3326FFEDCF7C6472" modified="2009-03-03" version="1">MSAQETHTPYHFETLQLHVGQESADPASDARAVPIYQTTSYVFHDFDHAEARFGLADPGNIYGRLTNTTQGVFEDRIAALEGGTAGLAVASGAAAVEYAVRNITQAGDHIVAAKNIYGGTFNLLRHTLPRDGITTTFVDANDPHAFEEAIADNTKLVYFETFGNPNADLPDFDAITEIAHRAHLPVIVDNTFATPYLFRPLEHGADIVVESVTKFIGGHGTTLGGVIVEGGDFKWDAVPGKFPTLTEPDPSYHGLNFYEALGPVSFVTRIRAVLLRDTGATLSPFSAFLLLQGTETLSLRVERHVENALKVIDYLKTVPEVESISHPSIEGRPDHDLYEKYFPNGAGSIFTFDIRGGKDAARVFIDNLHLFSLLANVADAKSLVIHPASTTHSQESETELEDQGIHQGTIRLSIGTEYIDDIIDDLKGGFEAVRASGFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTF4</accession>
    <name>B8DTF4_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="2">P5C reductase</shortName>
            <shortName evidence="2">P5CR</shortName>
            <ecNumber evidence="2">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">proC</name>
        <name evidence="5" type="ordered locus">BLA_0993</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217670.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0993"/>
    <dbReference type="EnsemblBacteria" id="ACL29283">
        <property type="protein sequence ID" value="ACL29283"/>
        <property type="gene ID" value="BLA_0993"/>
    </dbReference>
    <dbReference type="GeneID" id="66533394"/>
    <dbReference type="KEGG" id="bla:BLA_0993"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1036"/>
    <dbReference type="HOGENOM" id="CLU_042344_3_1_11"/>
    <dbReference type="OMA" id="VVRVMTN"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="3">
        <location>
            <begin position="2"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="4">
        <location>
            <begin position="166"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="264" mass="27301" checksum="0CE8369D133140FA" modified="2009-03-03" version="1">MKVGFIGYGNMAQAIAQGLTRAHAVDGNDIVACAAHFDKLERNIAAVGGTAMHTPQEVVAAADMVVVAIKPYQVEDVLAPMAGALADDSKMLVSLAAGWDLARYQTLFGGAATGIHIQCTIPNTPMAVAQGVLICENVNTLTPSQCQGFVDLFSRISLIEEVDTAHMGIAMCIAGCAPAFTDMYLEALGDAGVKYGLQRATAYRLAAKMIEGVGALCLDSGVHPGAMKDAVCSPGGTTIKGVAELENRAFRGAVISAVDAIEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTK5</accession>
    <name>B8DTK5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative binding protein-dependent transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_1046</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1046"/>
    <dbReference type="EnsemblBacteria" id="ACL29334">
        <property type="protein sequence ID" value="ACL29334"/>
        <property type="gene ID" value="BLA_1046"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1046"/>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="238" mass="26260" checksum="66BAD13126F4A147" modified="2009-03-03" version="1">MAILFALLLNQKFKGRGLIRTLIFVPYVVSEVIVGTGWSLLLQKKGAVNQILESLGMHGVDWLANPKVAIWTLLLLISWKYIGFAVILMLAGMQSIPEELYEAAKVDGAGFWQIQKSITLPLLGATLRIWVFLSMIGSLQLFDLVYIIWGQYVSTTAGVSTMATYMVREGRGAGNYGYGSAVALIIFVISLIVALTYQHFVLNRDLDGALTEKKASKKRKKRQTAEDEALAVAMEGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTP2</accession>
    <name>B8DTP2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP binding protein of ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_1083</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218790.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1083"/>
    <dbReference type="EnsemblBacteria" id="ACL29371">
        <property type="protein sequence ID" value="ACL29371"/>
        <property type="gene ID" value="BLA_1083"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1083"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1136"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OMA" id="EVFCLIG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="36"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="68"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="284" mass="31049" checksum="E98E57D757242BCF" modified="2009-03-03" version="1">MSEATRKTKSNSDESTATQTPKASVATDIAAAIPAVEAKQVHKAFGDLHVLKGIDLTVEPGTVTVILGPSGSGKSTFLRLINQLETITGGEIDVDGEMIGYKKLPNGELQTLNDKEIARQRAKLGMVFQKFNLFPHMTALENVMEAPVHVLHMPKAEARKLAIKELERVGLGERLDYYPAQLSGGQQQRVAIARALAMKPEIMLFDEPTSALDPELVGEVLNVMRSLANDGMTMIVVTHEIGFAKEVADQIVFMDGGVVVERGTPDIIDHPKEERFQDFLQHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTR3</accession>
    <name>B8DTR3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218818.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29392">
        <property type="protein sequence ID" value="ACL29392"/>
        <property type="gene ID" value="BLA_1104"/>
    </dbReference>
    <dbReference type="GeneID" id="66532928"/>
    <dbReference type="KEGG" id="bla:BLA_1104"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1158"/>
    <dbReference type="HOGENOM" id="CLU_2217894_0_0_11"/>
    <dbReference type="OMA" id="FQWITIG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="113" mass="12253" checksum="0EF31ED1016C2951" modified="2009-03-03" version="1">MTQGMENRTMAQCEGADDKCNICPVRSWVQQHRTLLIVCFGVLGVLLLLMLGSRKTVLNIANQPSQAGGNAAKVMVIDNHGFSMFQWLTIGNGSNNRPTNSGNTSNCANAKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTS4</accession>
    <name>B8DTS4_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">S-ribosylhomocysteine lyase</fullName>
            <ecNumber evidence="4 14">4.4.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">AI-2 synthesis protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 14">Autoinducer-2 production protein LuxS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">luxS</name>
        <name evidence="15" type="ordered locus">BLA_1115</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 14">Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:17753"/>
            <dbReference type="ChEBI" id="CHEBI:29484"/>
            <dbReference type="ChEBI" id="CHEBI:58195"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.4.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="14">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the LuxS family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.21" evidence="4 14"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218832.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1115"/>
    <dbReference type="EnsemblBacteria" id="ACL29403">
        <property type="protein sequence ID" value="ACL29403"/>
        <property type="gene ID" value="BLA_1115"/>
    </dbReference>
    <dbReference type="GeneID" id="66532938"/>
    <dbReference type="KEGG" id="bla:BLA_1115"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1168"/>
    <dbReference type="HOGENOM" id="CLU_107531_2_1_11"/>
    <dbReference type="OMA" id="GPMGCLT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043768">
        <property type="term" value="F:S-ribosylhomocysteine lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009372">
        <property type="term" value="P:quorum sensing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00091">
        <property type="entry name" value="LuxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037005">
        <property type="entry name" value="LuxS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003815">
        <property type="entry name" value="S-ribosylhomocysteinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35799">
        <property type="entry name" value="PTHR35799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02664">
        <property type="entry name" value="LuxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006160">
        <property type="entry name" value="AI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01487">
        <property type="entry name" value="LUXSPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0071">Autoinducer synthesis</keyword>
    <keyword evidence="9 14" id="KW-0408">Iron</keyword>
    <keyword evidence="10 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0673">Quorum sensing</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ACL29403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="166" mass="18532" checksum="F93FD3168E09EA49" modified="2009-03-03" version="1">MADEPNTQSKPVVESFQLDHTKVKAPYVRYIDTETGPNGDVISNYDLRLVQPNENAIPTGGLHTIEHTIAVLLRERIPGYIDCSPFGCRTGFHLLTWGEHSTEDVAKALKESLEFIANEATWDDVPATTIESCGNYRDHSLFTAKEWAKDILAQGISSDPFERKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTW5</accession>
    <name>B8DTW5_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Guanylate kinase</fullName>
            <ecNumber evidence="2 9">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">gmk</name>
        <name evidence="11" type="ordered locus">BLA_1156</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for recycling GMP and indirectly, cGMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + GMP = ADP + GDP</text>
            <dbReference type="Rhea" id="RHEA:20780"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2 9"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218887.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1156"/>
    <dbReference type="EnsemblBacteria" id="ACL29444">
        <property type="protein sequence ID" value="ACL29444"/>
        <property type="gene ID" value="BLA_1156"/>
    </dbReference>
    <dbReference type="GeneID" id="66532981"/>
    <dbReference type="KEGG" id="bla:BLA_1156"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1214"/>
    <dbReference type="HOGENOM" id="CLU_001715_1_1_11"/>
    <dbReference type="OMA" id="EWAVVHG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:guanylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="10">
        <location>
            <begin position="16"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL29444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="209" mass="23311" checksum="3CE5A825B83B9126" modified="2009-03-03" version="1">MSEQSRQSQATERQGGRLIVLTGPTAVGKGTVETALRKAHPEVWVSVSATTRDPRPGERDGVNYWFISEPEFLRRQEAGEFLETAVVHGMAHYGTPLEPVREHLAGNVPTILEIDLQGARRVKERAKELGLDVVYVFIAPPSFDELKKRLIGRGTETPEQQAKRLETAKVELAAEPEFDVTIVNEQVDKAARDLWNVIAQEYGLPQDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTW6</accession>
    <name>B8DTW6_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Dihydroxy-acid dehydratase</fullName>
            <shortName evidence="15">DAD</shortName>
            <ecNumber evidence="14 15">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">ilvD</name>
        <name evidence="16" type="ordered locus">BLA_1157</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="15">Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13 15">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12 15">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14 15"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619949.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1157"/>
    <dbReference type="EnsemblBacteria" id="ACL29445">
        <property type="protein sequence ID" value="ACL29445"/>
        <property type="gene ID" value="BLA_1157"/>
    </dbReference>
    <dbReference type="GeneID" id="66532982"/>
    <dbReference type="KEGG" id="bla:BLA_1157"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1215"/>
    <dbReference type="HOGENOM" id="CLU_014271_4_2_11"/>
    <dbReference type="OMA" id="TQGRNMA"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 15" id="KW-0408">Iron</keyword>
    <keyword evidence="8 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="518"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="15">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="15">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ACL29445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="619" mass="66339" checksum="BDB32B8AB6FCAA08" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTY5</accession>
    <name>B8DTY5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">von Willebrand factor, type A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218926.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1176"/>
    <dbReference type="EnsemblBacteria" id="ACL29464">
        <property type="protein sequence ID" value="ACL29464"/>
        <property type="gene ID" value="BLA_1176"/>
    </dbReference>
    <dbReference type="GeneID" id="66533001"/>
    <dbReference type="KEGG" id="bla:BLA_1176"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1235"/>
    <dbReference type="HOGENOM" id="CLU_069615_2_0_11"/>
    <dbReference type="OMA" id="TGSMAVK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="80"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="334" mass="35441" checksum="80A5AB7FCF5FF862" modified="2009-03-03" version="1">MSTFGFAPALGWIGGSLVAAVMVACAVTCVVLHARRGADGTDETLWSCVRRVLACVIVALMAFTPSMVTKTTSRAISTTDVVIVSDITPSMGVQDARYGSKSDLSRLEAAKSAIADIVRDYPNSSFSAVSVGASGAVDVPLTPDTRAITNWAQSLDTEDSSSSSGSSLDVVIDPLLRALKSIRDAHPDDRIVLYIITDGEQTVRNTRRTFSSLRHYIDDACVIGVGSTTGGRIPSKTAGQWVTDPSTGQPGVSIMDEGQIRSLADELSGKVVITSANDTVASAQIAQQAGSWREDDTQKERTRINPIVWPLAIALAALLAWELGTWIATSRRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTY7</accession>
    <name>B8DTY7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218928.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1178"/>
    <dbReference type="EnsemblBacteria" id="ACL29466">
        <property type="protein sequence ID" value="ACL29466"/>
        <property type="gene ID" value="BLA_1178"/>
    </dbReference>
    <dbReference type="GeneID" id="66533003"/>
    <dbReference type="KEGG" id="bla:BLA_1178"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1237"/>
    <dbReference type="HOGENOM" id="CLU_130886_0_0_11"/>
    <dbReference type="OMA" id="RNRIAQT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="170" mass="19094" checksum="86075DBE6E429AD8" modified="2009-03-03" version="1">MIVAIDTQNLHPRGTIAITQSLWIALICDIVLALILIVACCVLSGTRRRPETTGSQDEETLPKKEWAARVNQVVARHDAQDITRDEAFAQLAAIARDFASNMSGRRMQANTLTDLRRLRRTGVAVNWDLLRQTIAALYPPEFAQAEHPQARGVSVRQAADWVLDLIERWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU00</accession>
    <name>B8DU00_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UspA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">uspA</name>
        <name evidence="3" type="ordered locus">BLA_1191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218155.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1191"/>
    <dbReference type="EnsemblBacteria" id="ACL29479">
        <property type="protein sequence ID" value="ACL29479"/>
        <property type="gene ID" value="BLA_1191"/>
    </dbReference>
    <dbReference type="GeneID" id="66533017"/>
    <dbReference type="KEGG" id="bla:BLA_1191"/>
    <dbReference type="HOGENOM" id="CLU_049301_2_3_11"/>
    <dbReference type="OMA" id="HHAPLQV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="15"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="188"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="325" mass="35202" checksum="E13CDD9965D3BF80" modified="2009-03-03" version="1">MEPATVQSLNPQGDLVVGVDGSQESFGALRWALRQAALSGQTVNAVYGWSYSWDMGPEPTTDEELAKLRTQIAEKLRDWVKDAAEGIDIDSDQIRLTSFRASGTSALLEIGSDAQQIVVGRRTLGRVARWFSGSLSSSLAEESQIPVTIIRVENEDQSVQDEIANALTPGSQEVHFELPAPDTPRTSRPIVVGVDGSPTSRRALEFSAWLANLNHAPLHVMYCWQLKDMTDIPGYETSVPPLDVAQQHAEQVVQHLIASSTLPEGLTIKADVFHISAGKGLVSASRYCRHIVVGSRGLSGADAHFLGSVSKQLINLAECNLTIVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU03</accession>
    <name>B8DU03_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate--tRNA(Asp/Asn) ligase</fullName>
            <ecNumber evidence="7">6.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">AspRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Non-discriminating aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">ND-AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">aspS</name>
        <name evidence="10" type="ordered locus">BLA_1194</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx)</text>
            <dbReference type="Rhea" id="RHEA:18349"/>
            <dbReference type="Rhea" id="RHEA-COMP:9710"/>
            <dbReference type="Rhea" id="RHEA-COMP:9711"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218152.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1194"/>
    <dbReference type="EnsemblBacteria" id="ACL29482">
        <property type="protein sequence ID" value="ACL29482"/>
        <property type="gene ID" value="BLA_1194"/>
    </dbReference>
    <dbReference type="GeneID" id="66533019"/>
    <dbReference type="KEGG" id="bla:BLA_1194"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1256"/>
    <dbReference type="HOGENOM" id="CLU_014330_3_2_11"/>
    <dbReference type="OMA" id="YQLDVEM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050560">
        <property type="term" value="F:aspartate-tRNA(Asn) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
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        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="148"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="7">
        <location>
            <begin position="205"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="567"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="227"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="544"/>
            <end position="547"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for tRNA non-discrimination" evidence="7">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="site" description="Important for tRNA non-discrimination" evidence="7">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL29482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="600" mass="67277" checksum="EDA41298E1722389" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU06</accession>
    <name>B8DU06_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218147.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1197"/>
    <dbReference type="ESTHER" id="bifa0-b8du06">
        <property type="family name" value="AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29485">
        <property type="protein sequence ID" value="ACL29485"/>
        <property type="gene ID" value="BLA_1197"/>
    </dbReference>
    <dbReference type="GeneID" id="66533022"/>
    <dbReference type="KEGG" id="bla:BLA_1197"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1259"/>
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    <dbReference type="OMA" id="ILMHGFK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="34"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="262" mass="28249" checksum="0DEDF3635AD3CF16" modified="2009-03-03" version="1">MTTSTHTEEITVMRDGLRLHGRIDAPQGEPKGPVVILMHGFMADLGYEPGSLLQQVSDQLVEAGFTSVRFDFNGRGNSDGSFANSDVCNQVEDAIAVLNFVRDRFEPAEISLLGHSQGGVIAGMTAGMYADVVHSLVLLSPAASIKDDALRGRVLGVPFDPYHIPRRIALADGKHEVAGKYSRIAKTIPVYEAAAMFKGPALAIQGEQDKVIDPSCAHNYGNAMANCTVSLYTNLDHKFNGDDRMRAIGEAVAFLQTHHEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU12</accession>
    <name>B8DU12_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable DEAD box-like helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1203"/>
    <dbReference type="EnsemblBacteria" id="ACL29491">
        <property type="protein sequence ID" value="ACL29491"/>
        <property type="gene ID" value="BLA_1203"/>
    </dbReference>
    <dbReference type="GeneID" id="66533028"/>
    <dbReference type="KEGG" id="bla:BLA_1203"/>
    <dbReference type="HOGENOM" id="CLU_017075_0_0_11"/>
    <dbReference type="OMA" id="DEFHFYA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021904">
        <property type="entry name" value="DUF3516"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12029">
        <property type="entry name" value="DUF3516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="54"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="252"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="862" mass="97029" checksum="C4B3D84C516F679B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU17</accession>
    <name>B8DU17_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29496">
        <property type="protein sequence ID" value="ACL29496"/>
        <property type="gene ID" value="BLA_1208"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1208"/>
    <dbReference type="HOGENOM" id="CLU_3285593_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="50" mass="5728" checksum="4981200584411D81" modified="2009-03-03" version="1">MNETWATRRFMSGDDMATALNPRTPRRAEITDEMQRRADQIIMTALESAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU23</accession>
    <name>B8DU23_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_1214</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218126.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1214"/>
    <dbReference type="EnsemblBacteria" id="ACL29502">
        <property type="protein sequence ID" value="ACL29502"/>
        <property type="gene ID" value="BLA_1214"/>
    </dbReference>
    <dbReference type="GeneID" id="66533038"/>
    <dbReference type="KEGG" id="bla:BLA_1214"/>
    <dbReference type="HOGENOM" id="CLU_095994_1_1_11"/>
    <dbReference type="OMA" id="FQVGKNG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001890">
        <property type="entry name" value="RNA-binding_CRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017924">
        <property type="entry name" value="RNA-binding_YhbY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035920">
        <property type="entry name" value="YhbY-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01985">
        <property type="entry name" value="CRS1_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01103">
        <property type="entry name" value="CRS1_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75471">
        <property type="entry name" value="SSF75471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00253">
        <property type="entry name" value="RNA_bind_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51295">
        <property type="entry name" value="CRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CRM" evidence="3">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="101" mass="11299" checksum="FFC1BEBF13617A78" modified="2009-03-03" version="1">MALTKKQVRQLRAMANQLKPLVQIGKGDLSDNVIKQADETIEKRELIKVQVLDGSGIDAKEAAQGLADRMGAEVVQVIGNRAVLYRRSHRDDIEHIQLVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU25</accession>
    <name>B8DU25_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cobalt import ATP-binding/permease protein CbiO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cbiO</name>
        <name evidence="10" type="ordered locus">BLA_1216</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218124.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1216"/>
    <dbReference type="EnsemblBacteria" id="ACL29504">
        <property type="protein sequence ID" value="ACL29504"/>
        <property type="gene ID" value="BLA_1216"/>
    </dbReference>
    <dbReference type="GeneID" id="66533040"/>
    <dbReference type="KEGG" id="bla:BLA_1216"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1278"/>
    <dbReference type="HOGENOM" id="CLU_000604_38_1_11"/>
    <dbReference type="OMA" id="RTHWRVM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="526"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="567"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="604"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="744"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="8"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="273"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="307"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL29504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="765" mass="82428" checksum="EB03E5E7208E974B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU26</accession>
    <name>B8DU26_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Riboflavin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_1217</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic riboflavin transporter (P-RFT) (TC 2.A.87) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218122.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1217"/>
    <dbReference type="EnsemblBacteria" id="ACL29505">
        <property type="protein sequence ID" value="ACL29505"/>
        <property type="gene ID" value="BLA_1217"/>
    </dbReference>
    <dbReference type="GeneID" id="66533041"/>
    <dbReference type="KEGG" id="bla:BLA_1217"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1279"/>
    <dbReference type="HOGENOM" id="CLU_086673_0_0_11"/>
    <dbReference type="OMA" id="MFLEFPI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032217">
        <property type="term" value="F:riboflavin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009825">
        <property type="entry name" value="ECF_substrate-spec-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025720">
        <property type="entry name" value="RibU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38438">
        <property type="entry name" value="PTHR38438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07155">
        <property type="entry name" value="ECF-ribofla_trS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037778">
        <property type="entry name" value="UCP037778_transp_RibU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="198" mass="21008" checksum="73443D0FC5667A8D" modified="2009-03-03" version="1">MSVFSHPDSISPNQVSGSHSTGAADRGRWSTQRIAMYALFVALAMAVSFIEIPLMPAAPWLKYDPSGIVCILAGFAFGPSGAVIVSVLGFVPHLFVNPLGAVMAILVALGYSLPVAFIYRRRSTRTGALTGILLGAAVALAAAIVGNLFITPLYAHMSMQQVASMIVPILLPFNLLKFAINGVVSFLCYRPVCKLIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU63</accession>
    <name>B8DU63_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1254"/>
    <dbReference type="EnsemblBacteria" id="ACL29542">
        <property type="protein sequence ID" value="ACL29542"/>
        <property type="gene ID" value="BLA_1254"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1254"/>
    <dbReference type="HOGENOM" id="CLU_104072_0_0_11"/>
    <dbReference type="OMA" id="TFVDKYC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="34"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="161" mass="18308" checksum="5508CE5D121349A4" modified="2009-03-03" version="1">MLDDGGIHAIVNAYGADILSHEQMQIERDSLQHGAVTTYEHSIAVACLSVKIADRLHLWHHVNLRSLVRAALLHDYFLYDWHEKDNGSHRLHGFRHPYTAERNARADFELDDIVSNSIRTHMFPLTPIPPKYLEGVIVNIADTLCAIRETLSPSRFHAAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU67</accession>
    <name>B8DU67_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hemolysin-like protein with S4 domain found in bacteria and plants</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TlyA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1258"/>
    <dbReference type="EnsemblBacteria" id="ACL29546">
        <property type="protein sequence ID" value="ACL29546"/>
        <property type="gene ID" value="BLA_1258"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1258"/>
    <dbReference type="HOGENOM" id="CLU_058015_1_0_11"/>
    <dbReference type="OMA" id="VLMVKPQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004538">
        <property type="entry name" value="Haemolysin_A/TlyA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32319:SF0">
        <property type="entry name" value="PTHR32319:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005578">
        <property type="entry name" value="TlyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="2">
        <location>
            <begin position="11"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="259" mass="27952" checksum="8C017F30013F9AF3" modified="2009-03-03" version="1">MEYEHTGMREERLDVVVANATGESRSKAQRLIKTGKVHVNGHPQTKPAYAVQPESTISVHMAMEDDYVSRGALKLLGAFNAFAPAGFTSVEGKHCLDIGASTGGFCDVLLRRGAAQVIALDVGHGQLDPRIADDPRVIEMSGVNMRYVGVDDLPYRPDVIVSDVSFISLTYLMAAIAEVAAPAAQIVLLVKPQFEVGQKGRLGKNGIVTDPSLREQALERVERCAREHGLQVVASAPSPIEGTHGNAEYLLYLRMSQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU86</accession>
    <name>B8DU86_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_1278</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1278"/>
    <dbReference type="EnsemblBacteria" id="ACL29565">
        <property type="protein sequence ID" value="ACL29565"/>
        <property type="gene ID" value="BLA_1278"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1278"/>
    <dbReference type="HOGENOM" id="CLU_093751_0_0_11"/>
    <dbReference type="OMA" id="VSHNHRA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004509">
        <property type="entry name" value="Competence_ComEA_HhH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00426">
        <property type="entry name" value="TIGR00426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870499" evidence="2">
        <location>
            <begin position="17"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="3">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="3">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="236" mass="24740" checksum="DC4BACDC093EDA92" modified="2009-03-03" version="1">MTRLRHLGGPSSRSMAAGSSTGPGFSIQMPSVPLPPPPGVQEPSVTASNEQSSGGVREVSGDDQKAGALLSSLTVVNDDDFEAERGVRRLERPRFELEPKHALLCIMVLVCALATTLTLLVQQAANMGALDTQATTNASSHTTATASPSDRDSTPSTAAPEPSPSASDNKQDTLVNINTADEAQLQEIKGIGPVTAARIIEYRTQHGAFASLDDLVNVPGIGMKTVEKLRPWACAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU93</accession>
    <name>B8DU93_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein involved in colicin uptake</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218029.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29572">
        <property type="protein sequence ID" value="ACL29572"/>
        <property type="gene ID" value="BLA_1285"/>
    </dbReference>
    <dbReference type="GeneID" id="66533111"/>
    <dbReference type="KEGG" id="bla:BLA_1285"/>
    <dbReference type="HOGENOM" id="CLU_1583321_0_0_11"/>
    <dbReference type="OMA" id="YHEHTTS"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="168" mass="18689" checksum="56BF6EA673603C3B" modified="2009-03-03" version="1">MEPVQPNMPKSSDDHGDTSSTASSTHRNASIIVMLCLAIVFAAGAALIVHNMNVSHLTHARHMCAAASDKLRIAMNTYTYLHDSEASKAYHLGTYDVQDPNVLVQFAKEYEEKAPEITGCNADSVEELQRRTGRIMENTGWYTTHHDRLKELTELVNESRRDTVSGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUA9</accession>
    <name>B8DUA9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, TetR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_1301</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218004.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29588">
        <property type="protein sequence ID" value="ACL29588"/>
        <property type="gene ID" value="BLA_1301"/>
    </dbReference>
    <dbReference type="GeneID" id="66533127"/>
    <dbReference type="KEGG" id="bla:BLA_1301"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1363"/>
    <dbReference type="HOGENOM" id="CLU_100170_0_0_11"/>
    <dbReference type="OMA" id="NWIIVNG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TetR_C_33" evidence="4">
        <location>
            <begin position="84"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="189" mass="21505" checksum="426D7F1CCDC68554" modified="2009-03-03" version="1">MPRPPRFTQEEVAVAAFDIVRGGGEESLTARSLAEKLGCSVKPIFGLFDTMDEVRQAVWEQANAWYIERLDAAMSAGDRPPYLASGLAYIEFARTEPNLFTLLFMHRRTPEQMEQSSIQLRPVIEIIARQLGVGYDEAYAFHMRMWVYVHGIASMIVTGYLDWDEAFAEHSLSDMFHALSEYTETKQGE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUE8</accession>
    <name>RUVA_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Holliday junction ATP-dependent DNA helicase RuvA</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ruvA</name>
        <name type="ordered locus">BLA_1342</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with RuvB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RuvA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217958.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DUE8"/>
    <dbReference type="SMR" id="B8DUE8"/>
    <dbReference type="STRING" id="442563.BLA_1342"/>
    <dbReference type="EnsemblBacteria" id="ACL29627">
        <property type="protein sequence ID" value="ACL29627"/>
        <property type="gene ID" value="BLA_1342"/>
    </dbReference>
    <dbReference type="GeneID" id="66533167"/>
    <dbReference type="KEGG" id="bla:BLA_1342"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1404"/>
    <dbReference type="HOGENOM" id="CLU_087936_2_1_11"/>
    <dbReference type="OMA" id="VGMAVQC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009379">
        <property type="term" value="C:Holliday junction helicase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14332">
        <property type="entry name" value="UBA_RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00031">
        <property type="entry name" value="DNA_helic_RuvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013849">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvA_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000085">
        <property type="entry name" value="RuvA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011114">
        <property type="entry name" value="RuvA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036267">
        <property type="entry name" value="RuvA_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07499">
        <property type="entry name" value="RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01330">
        <property type="entry name" value="RuvA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46929">
        <property type="entry name" value="SSF46929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00084">
        <property type="entry name" value="ruvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_1000195119" description="Holliday junction ATP-dependent DNA helicase RuvA">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00031"/>
        </source>
    </evidence>
    <sequence length="207" mass="22053" checksum="E4F0D07E33D15DF0" modified="2009-03-03" version="1">MIGMLKGRVESVDTSNAVVDVHGVGFELRMPSNDLTAMHMGQDVKIYTSMSVSQDAITLFGFLDARSKRMFLQLQKVSGVGPKVALSLLSTLAPDDLAQAIHDGDDKALSRAPGLGRKGAQKIILELKGSIDVDKIETGEPTSTQRIPTDKGVEQVVEGLMSLGWKQADAQQAVDSVISSSGIALPLEEGNVPTVLRLALTSLDRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUF7</accession>
    <name>B8DUF7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217946.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29636">
        <property type="protein sequence ID" value="ACL29636"/>
        <property type="gene ID" value="BLA_1351"/>
    </dbReference>
    <dbReference type="GeneID" id="66533177"/>
    <dbReference type="KEGG" id="bla:BLA_1351"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1413"/>
    <dbReference type="HOGENOM" id="CLU_208319_0_0_11"/>
    <dbReference type="OMA" id="IDHGKYY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="59" mass="7015" checksum="1E841A8AB71FF69C" modified="2009-03-03" version="1">MVWIIAAIVILAISVYFANEYRLDRKAHRLRDGSEEDRRLASELQDIARNMDEGKYLYR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUG2</accession>
    <name>HRCA_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heat-inducible transcription repressor HrcA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hrcA</name>
        <name type="ordered locus">BLA_1356</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HrcA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217935.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DUG2"/>
    <dbReference type="SMR" id="B8DUG2"/>
    <dbReference type="STRING" id="442563.BLA_1356"/>
    <dbReference type="EnsemblBacteria" id="ACL29641">
        <property type="protein sequence ID" value="ACL29641"/>
        <property type="gene ID" value="BLA_1356"/>
    </dbReference>
    <dbReference type="GeneID" id="66533187"/>
    <dbReference type="KEGG" id="bla:BLA_1356"/>
    <dbReference type="HOGENOM" id="CLU_050019_2_0_11"/>
    <dbReference type="OMA" id="DYPGTMG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00081">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002571">
        <property type="entry name" value="HrcA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021153">
        <property type="entry name" value="HrcA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023120">
        <property type="entry name" value="WHTH_transcript_rep_HrcA_IDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34824">
        <property type="entry name" value="PTHR34824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01628">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005485">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00331">
        <property type="entry name" value="hrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_1000118290" description="Heat-inducible transcription repressor HrcA">
        <location>
            <begin position="1"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="366" mass="39638" checksum="0859C2B9C3A0AD13" modified="2009-03-03" version="1">MSSTRRMQILRAVVEDYIRQQEPIGSGALAAKHHLGVSPATIRNDMAALEDEGYLTQPHTSAGRIPTEKGYRYFVNSLSTPIPLTAEQRESISSALSGSASLQDTLQRAARILSTITGQYAMVSAPSLSRSLMRHVELLPLAAHTLLLVTITETGRVVQRLVSTDTLPNTEQTQCICETINTHCRLLTFRQCAQSIRTLPTDSEGGFTPQLRDAIAAVFSDMENEERPNELFTSGAASLTHQHIDAASLAPLFDALEEQVVLMRLMYDLTGQPGQEGVGVAIGSETHTPGLLHASVVSSGYGQSSTPSANVEHEEYDTGTKPTMPIAVIGSIGPTHMNYAVTMAAVHAVSRYLTEFLRVGHNGWQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUH7</accession>
    <name>B8DUH7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29656">
        <property type="protein sequence ID" value="ACL29656"/>
        <property type="gene ID" value="BLA_1371"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1371"/>
    <dbReference type="HOGENOM" id="CLU_3305409_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="39" mass="4308" checksum="7910FA1D56A0D884" modified="2009-03-03" version="1">MTAGTGIAGDFHEIIGKMPPGSWRMALENRHVSPYRLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUI7</accession>
    <name>B8DUI7_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Alkyl hydroperoxide reductase C</fullName>
            <ecNumber evidence="4 11">1.11.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 11">Peroxiredoxin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ahpC</name>
        <name evidence="13" type="ordered locus">BLA_1381</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>a hydroperoxide + H(+) + NADH = an alcohol + H2O + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:62628"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.11.1.26"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.26" evidence="4 11"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217905.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1381"/>
    <dbReference type="EnsemblBacteria" id="ACL29666">
        <property type="protein sequence ID" value="ACL29666"/>
        <property type="gene ID" value="BLA_1381"/>
    </dbReference>
    <dbReference type="GeneID" id="66533211"/>
    <dbReference type="KEGG" id="bla:BLA_1381"/>
    <dbReference type="HOGENOM" id="CLU_042529_21_3_11"/>
    <dbReference type="OMA" id="FWYPKDF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102039">
        <property type="term" value="F:alkylhydroperoxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017559">
        <property type="entry name" value="AhpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF121">
        <property type="entry name" value="PTHR10681:SF121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03137">
        <property type="entry name" value="AhpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="2"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="10">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACL29666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="187" mass="21151" checksum="5E7B33ED1B58F7E3" modified="2009-03-03" version="1">MSMLQHNLIDFSVEAYHDGALETIGKEDLLGHWSVLFFYPADFSFVCPTELEDLQDHYAEFKKAGCEIYSVSCDTQWVHKAWHDANEKIGKVQYPMLADTTGKLARDLETYNEESGLAERGDFIIDPEGKVVAYEVISSNVGRNAEEILRRVKASQFVYEHGDQVCPAKWEPGDETLEPSLDLVGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUM3</accession>
    <name>B8DUM3_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proton-translocating NAD(P)(+) transhydrogenase</fullName>
            <ecNumber evidence="3">7.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">BLA_1417</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269096.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1417"/>
    <dbReference type="EnsemblBacteria" id="ACL29702">
        <property type="protein sequence ID" value="ACL29702"/>
        <property type="gene ID" value="BLA_1417"/>
    </dbReference>
    <dbReference type="GeneID" id="66533246"/>
    <dbReference type="KEGG" id="bla:BLA_1417"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1481"/>
    <dbReference type="HOGENOM" id="CLU_137885_1_1_11"/>
    <dbReference type="OMA" id="FVVTDRM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024605">
        <property type="entry name" value="NADP_transhyd_a_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12769">
        <property type="entry name" value="PNTB_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="PNTB_4TM" evidence="11">
        <location>
            <begin position="8"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACL29702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="103" mass="10871" checksum="FB077CA716DC59AE" modified="2009-03-03" version="1">MPDLVVSITLFILALIIGIEVIGKVPATLHTPLMSGANSIHGIVIVGVVIVAAEANNWLSYVFIFLAAVLGTMNVVGGYVVTDRMLEMFKSNKDDAKGKGGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUP4</accession>
    <name>B8DUP4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29723">
        <property type="protein sequence ID" value="ACL29723"/>
        <property type="gene ID" value="BLA_1439"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1439"/>
    <dbReference type="HOGENOM" id="CLU_3040822_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867545" evidence="1">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="54" mass="5589" checksum="859C3AE70C92B459" modified="2009-03-03" version="1">MVIQHMHTAFRRTAGIGVALATLCADVVIAAPNAANAAPADTGSPGCRRPRAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUP5</accession>
    <name>B8DUP5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29724">
        <property type="protein sequence ID" value="ACL29724"/>
        <property type="gene ID" value="BLA_1440"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1440"/>
    <dbReference type="HOGENOM" id="CLU_2314685_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="99" mass="11222" checksum="148F176C0F136753" modified="2009-03-03" version="1">MPAMTRHPNAIGCGLRYGKPCVMRAMRGGGTSNTQGKATKMRRRMHAIGKRHTLMEIPCKRMHALIVEDLWNPRMAARKMHTSGKRRLHMRSCIASPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUP9</accession>
    <name>B8DUP9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methylase of polypeptide chain release factors</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29728">
        <property type="protein sequence ID" value="ACL29728"/>
        <property type="gene ID" value="BLA_1444"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1444"/>
    <dbReference type="HOGENOM" id="CLU_1821641_0_0_11"/>
    <dbReference type="OMA" id="RCVANID"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="126" mass="14395" checksum="CE9DDF89205EACD4" modified="2009-03-03" version="1">MDYDEKDPDNNTIAAIGWHDGLSQKEVWSCSAGWWKLEPGRAVRCDIGIVLNPDNVVVCVAKIKGIVKREDMRMWFLGDLAGERYEPWIGKTFERNDSKNPIAYFDEHAIIPPESVTNKMTILNSR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUT6</accession>
    <name>PHK_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable phosphoketolase</fullName>
            <ecNumber evidence="1">4.1.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">BLA_1483</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the XFP family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.-" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217768.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DUT6"/>
    <dbReference type="SMR" id="B8DUT6"/>
    <dbReference type="STRING" id="442563.BLA_1483"/>
    <dbReference type="EnsemblBacteria" id="ACL29765">
        <property type="protein sequence ID" value="ACL29765"/>
        <property type="gene ID" value="BLA_1483"/>
    </dbReference>
    <dbReference type="GeneID" id="66533313"/>
    <dbReference type="KEGG" id="bla:BLA_1483"/>
    <dbReference type="HOGENOM" id="CLU_013954_2_0_11"/>
    <dbReference type="OMA" id="LSTMDHC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01403">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023962">
        <property type="entry name" value="Phosphoketolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PTHR31273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="chain" id="PRO_1000184576" description="Probable phosphoketolase">
        <location>
            <begin position="1"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01403"/>
        </source>
    </evidence>
    <sequence length="825" mass="92502" checksum="0E1D963806C61797" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUX0</accession>
    <name>B8DUX0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-glucosidase</fullName>
            <ecNumber evidence="2">3.2.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">agl</name>
        <name evidence="2" type="ordered locus">BLA_1517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.10" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015940200.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1517"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29799">
        <property type="protein sequence ID" value="ACL29799"/>
        <property type="gene ID" value="BLA_1517"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1517"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1588"/>
    <dbReference type="HOGENOM" id="CLU_006462_1_1_11"/>
    <dbReference type="OMA" id="RDWYWWR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="31"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="611" mass="68790" checksum="6FE41D48C7B1C3FB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUX9</accession>
    <name>B8DUX9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable NhaP-type Na(+)/H(+) exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BLA_1526</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218973.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1526"/>
    <dbReference type="EnsemblBacteria" id="ACL29808">
        <property type="protein sequence ID" value="ACL29808"/>
        <property type="gene ID" value="BLA_1526"/>
    </dbReference>
    <dbReference type="GeneID" id="66533923"/>
    <dbReference type="KEGG" id="bla:BLA_1526"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1601"/>
    <dbReference type="HOGENOM" id="CLU_005912_6_2_11"/>
    <dbReference type="OMA" id="TYNTEHC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004705">
        <property type="entry name" value="Cation/H_exchanger_CPA1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="PTHR10110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00831">
        <property type="entry name" value="a_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 6" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="7">
        <location>
            <begin position="9"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="690" mass="76391" checksum="B40BEFCFD5A83727" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUY8</accession>
    <name>B8DUY8_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BLA_1535</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1535"/>
    <dbReference type="EnsemblBacteria" id="ACL29817">
        <property type="protein sequence ID" value="ACL29817"/>
        <property type="gene ID" value="BLA_1535"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1535"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1611"/>
    <dbReference type="HOGENOM" id="CLU_000288_135_6_11"/>
    <dbReference type="OMA" id="MTTPYIV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="546"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="10"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="347"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL29817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="653" mass="70333" checksum="7139AA2E2B43510B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUZ1</accession>
    <name>B8DUZ1_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="6">2.1.1.182</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmA</name>
        <name evidence="6 9" type="synonym">ksgA</name>
        <name evidence="9" type="ordered locus">BLA_1538</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:19609"/>
            <dbReference type="Rhea" id="RHEA-COMP:10232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10233"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.182"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="6"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218989.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1538"/>
    <dbReference type="EnsemblBacteria" id="ACL29820">
        <property type="protein sequence ID" value="ACL29820"/>
        <property type="gene ID" value="BLA_1538"/>
    </dbReference>
    <dbReference type="GeneID" id="66533936"/>
    <dbReference type="KEGG" id="bla:BLA_1538"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1616"/>
    <dbReference type="HOGENOM" id="CLU_041220_1_1_11"/>
    <dbReference type="OMA" id="KEEEPYF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="8">
        <location>
            <begin position="42"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL29820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="297" mass="31985" checksum="4245F67BB04DC910" modified="2009-03-03" version="1">MGTAQADGGNLLGAADIRRIAAEEGITPTKKFGQNFVIDPGTVRKIVREAGVDAGDQVMEVGPGLGSLTLAILETGADLTAVEIDPPLAQRLPQTIAEFMPNATNRFRVVNMDALKVTPSQLPQLADAATFTLVANLPYNVATPILLTLLERFGNLDSFLVMVQKEVAERLSAQPGSKVYGTPSVKLAWYGTAKSVGNIGRNVFWPAPNVDSALVRFERHAADDPRNPNNRSVGRDLVFRLIDASFAQRRKTLHAALRKIVPSGAFERAGIDPTRRGETLDIDEFVALATACKELEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV00</accession>
    <name>B8DV00_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative partitioning or sporulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219005.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1547"/>
    <dbReference type="EnsemblBacteria" id="ACL29829">
        <property type="protein sequence ID" value="ACL29829"/>
        <property type="gene ID" value="BLA_1547"/>
    </dbReference>
    <dbReference type="GeneID" id="66533945"/>
    <dbReference type="KEGG" id="bla:BLA_1547"/>
    <dbReference type="HOGENOM" id="CLU_037612_8_0_11"/>
    <dbReference type="OMA" id="VQCEYFA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="55"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="324" mass="35285" checksum="963B8862D808026C" modified="2009-03-03" version="1">MTHQGSSPEFESAEDTIARIFSDHENSGVGSEIADASTRLHALERLKFKQPAQTRRIAVANQKGGVGKTSTTVNLAAALALAGMNVLVIDMDPQGNASTALGAKHNSGDPSVYDVIEGRAGIADVMQTCPEFPTLQVVPASIDLSGAELEISDLPNRNDLLDEALDKFLDESEIHYDYVFVDCAPSLGLLVINAMCAVNEMLIPIQAEYYALEGLGQLINTIGLVQTHFNPLLLVSTMLVTMFDKRTLLSREVYQEVKTHYPSIVLDTTIPRTVKISEAPSFGETVITYDPRGLGAISYREAAYEINERSQIVLETIASRRNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV19</accession>
    <name>B8DV19_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0015"/>
    <dbReference type="EnsemblBacteria" id="ACL28320">
        <property type="protein sequence ID" value="ACL28320"/>
        <property type="gene ID" value="BLA_0015"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0015"/>
    <dbReference type="HOGENOM" id="CLU_065947_1_0_11"/>
    <dbReference type="OMA" id="RLNWRLM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002725">
        <property type="entry name" value="YgjP-like_metallopeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01863">
        <property type="entry name" value="DUF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF45" evidence="2">
        <location>
            <begin position="43"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="252" mass="29303" checksum="7B181289182C15B9" modified="2009-03-03" version="1">MPFNSVPRARSISRRAQFDRSTRAREVLNVDGLQVNVLRKKNRNMYLRVKPPYGAIEVTAPVRMPQHTIVEFVRERRSWVDEALHKMAQARSRTFASPDLDPDVGGSRTTVLRDARDPGSPRMETPHETSSFTWNEEYVERARRSIEQQLPDLLSKWTPIVGKSPTKITLRTMTSRWGSCTPKTGRIRLNLQLGLMDPQFLEYVLVHELTHLWESGHGRTFQERMSLVLPNWKELRRELNRCTIFDVPQSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV40</accession>
    <name>B8DV40_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PemI-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219074.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28341">
        <property type="protein sequence ID" value="ACL28341"/>
        <property type="gene ID" value="BLA_0036"/>
    </dbReference>
    <dbReference type="GeneID" id="66532412"/>
    <dbReference type="KEGG" id="bla:BLA_0036"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.37"/>
    <dbReference type="HOGENOM" id="CLU_150554_1_1_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="4"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="86" mass="9360" checksum="E3F7B87FD5A9E253" modified="2009-03-03" version="1">MTMLTLSKWGNAQAVRLPKAMREQVGMPDDSQIEATVENGAIVLKPARSAKRAIRVANLASVFKDRKEPYRACEDDFGAPAGNEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV77</accession>
    <name>B8DV77_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pknB</name>
        <name evidence="11" type="ordered locus">BLA_0075</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218367.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0075"/>
    <dbReference type="EnsemblBacteria" id="ACL28378">
        <property type="protein sequence ID" value="ACL28378"/>
        <property type="gene ID" value="BLA_0075"/>
    </dbReference>
    <dbReference type="GeneID" id="66532450"/>
    <dbReference type="KEGG" id="bla:BLA_0075"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.80"/>
    <dbReference type="HOGENOM" id="CLU_000288_135_2_11"/>
    <dbReference type="OMA" id="DPDYRYQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="13"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="398"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="466"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="538"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="598"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="639"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL28378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="710" mass="75544" checksum="285644F93C5759AE" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVA1</accession>
    <name>B8DVA1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218396.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28402">
        <property type="protein sequence ID" value="ACL28402"/>
        <property type="gene ID" value="BLA_0099"/>
    </dbReference>
    <dbReference type="GeneID" id="66532476"/>
    <dbReference type="KEGG" id="bla:BLA_0099"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.105"/>
    <dbReference type="HOGENOM" id="CLU_163177_0_0_11"/>
    <dbReference type="OMA" id="CAHTVFA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="87" mass="9566" checksum="65619BB32CE20BBF" modified="2009-03-03" version="1">MGILFINGGEIGGNTAHLGHAFLEGRDFTQIDLAGKRLFFLFRGGAPTQQMYERGEYTINRFAGLYGMDYMGMARNASEARALAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVA7</accession>
    <name>B8DVA7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218401.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0105"/>
    <dbReference type="EnsemblBacteria" id="ACL28408">
        <property type="protein sequence ID" value="ACL28408"/>
        <property type="gene ID" value="BLA_0105"/>
    </dbReference>
    <dbReference type="GeneID" id="66532480"/>
    <dbReference type="KEGG" id="bla:BLA_0105"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.109"/>
    <dbReference type="HOGENOM" id="CLU_070025_0_0_11"/>
    <dbReference type="OMA" id="QSAQIGY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="17"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="153"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="255" mass="28204" checksum="883AAB4DE260BF65" modified="2009-03-03" version="1">MAGITEQPNERLKETDPQFAERMLHFADVEVARDPETELEPTTRYLAILATLLGCQGADEFRIQLGRALDAGLTPVQAKEVVHQAVDYLGIGRVRPFLAITNEVLEARGVALPLPDQTTTTMENRLEAGNAKQVELFGEGMDKSYERSKVNYWLADNCFGDYYTRTGLTNLQREMITFCYLAAQGSVEPQLLAHTKANIALGNTADFLRTVVLQNLPYIGYPRTLNALRIVAEADKAKQGAAFNLQALAWGRAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVD8</accession>
    <name>B8DVD8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="WP_012619645.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28439">
        <property type="protein sequence ID" value="ACL28439"/>
        <property type="gene ID" value="BLA_0136"/>
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    <dbReference type="GO" id="GO:0006355">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014795">
        <property type="entry name" value="Vibrio_phage_ICP1_Orf50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35401">
        <property type="entry name" value="PTHR35401"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08681">
        <property type="entry name" value="DUF1778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="98" mass="11422" checksum="BF2506D94196264A" modified="2009-03-03" version="1">MYGVMPYNIVMATMTRTARIDMRLTEEEKRLIEQASAATGSRLTTWCINNLINDAKRDLHANAIIRLSDEAFDRFVENLDRPLTEKQQQFLAYQPEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVE4</accession>
    <name>B8DVE4_BIFA0</name>
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        <submittedName>
            <fullName evidence="2">Beta-D-mannosidase</fullName>
        </submittedName>
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        <name evidence="2" type="ordered locus">BLA_0142</name>
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    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0142"/>
    <dbReference type="EnsemblBacteria" id="ACL28445">
        <property type="protein sequence ID" value="ACL28445"/>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1217905_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867564" evidence="1">
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            <begin position="26"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="250" mass="27463" checksum="25788874AD0A0B57" modified="2009-03-03" version="1">MRGRTMKVKKIAAIALASACAFSMAAVDFNGHRKPVWYASRDFFAPRLATIQPRTSEEYRETHSWEGVKVDADHLELIVLNDTNEPYKGSWAVNRVDFDGNVLATQQIDDVELDAASHKGFPLNEEIVDFGDANNELIVAVPSDDSFARVIYNPAEILTQELDAPADAFTTKAKRTADGVELTVTANDYVRDLFCMVGKVDDKATVEEGLVSLLPGESVTFHIGTDYAGDPADFAAANVLRSANDLKRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVE7</accession>
    <name>B8DVE7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218453.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0145"/>
    <dbReference type="EnsemblBacteria" id="ACL28448">
        <property type="protein sequence ID" value="ACL28448"/>
        <property type="gene ID" value="BLA_0145"/>
    </dbReference>
    <dbReference type="GeneID" id="66532520"/>
    <dbReference type="KEGG" id="bla:BLA_0145"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.153"/>
    <dbReference type="HOGENOM" id="CLU_1150112_0_0_11"/>
    <dbReference type="OMA" id="VIIAPHK"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="243" mass="26623" checksum="55A37CD9B940AB23" modified="2009-03-03" version="1">MEGKQPKLTPEQREAIDTLSSTPQYQGESKIKIFMKIPAKDKAAYSRTHFLVPLLAAVIVIALGTFVIVRLVSPVPRPALYAAAVSGSTPMGEADKLKDDYAKKLGKDVIIDDYFDMNKDGLSKLQTMIGNEQIDVVIAPHDVFAKLASFGYFDNLKTTLPAAEYAKVGKYAMAFHGFDDSRVTDAIDESGSGQGKSEPYGLLLEHAPRWDRIEGADDDALVGIAANTQQLDTAKNFIQYLYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVF5</accession>
    <name>B8DVF5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">aapA</name>
        <name evidence="10" type="ordered locus">BLA_0153</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268961.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0153"/>
    <dbReference type="EnsemblBacteria" id="ACL28456">
        <property type="protein sequence ID" value="ACL28456"/>
        <property type="gene ID" value="BLA_0153"/>
    </dbReference>
    <dbReference type="GeneID" id="66532527"/>
    <dbReference type="KEGG" id="bla:BLA_0153"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.161"/>
    <dbReference type="HOGENOM" id="CLU_007946_9_3_11"/>
    <dbReference type="OMA" id="AIMCIVP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="477"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="9">
        <location>
            <begin position="40"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL28456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="514" mass="56729" checksum="D910BCC6958DDA0B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVJ9</accession>
    <name>B8DVJ9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0198"/>
    <dbReference type="EnsemblBacteria" id="ACL28500">
        <property type="protein sequence ID" value="ACL28500"/>
        <property type="gene ID" value="BLA_0198"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0198"/>
    <dbReference type="HOGENOM" id="CLU_157938_0_1_11"/>
    <dbReference type="OMA" id="CAAKERA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025338">
        <property type="entry name" value="DUF4244"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14029">
        <property type="entry name" value="DUF4244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="106" mass="11716" checksum="A8A231FAB0211457" modified="2009-03-03" version="1">MGNTTYRPTKQARRDMEHNEVILFEHRRHGVGERINAASDRLLRAQVGLEARWRALMSQPEEGAATAEYAVVLVAATGFAAVLVALMKSDTVKTLLTNIVKKALNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVL0</accession>
    <name>B8DVL0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol 1-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219311.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0209"/>
    <dbReference type="EnsemblBacteria" id="ACL28511">
        <property type="protein sequence ID" value="ACL28511"/>
        <property type="gene ID" value="BLA_0209"/>
    </dbReference>
    <dbReference type="GeneID" id="66532583"/>
    <dbReference type="KEGG" id="bla:BLA_0209"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.221"/>
    <dbReference type="HOGENOM" id="CLU_050011_0_0_11"/>
    <dbReference type="OMA" id="GTKEWAD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017815">
        <property type="entry name" value="Myo-inos-1-P_Synthase_actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03450">
        <property type="entry name" value="mycothiol_INO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inos-1-P_synth" evidence="2">
        <location>
            <begin position="190"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="380" mass="41594" checksum="CCE04BC4B1BB2695" modified="2009-03-03" version="1">MSIRVAIAGVGNCASSLVQGVEYYKDTKDEDKIPGLMHNNFGGYRVRDIEFVTAFDVDADKVGKDLSEAIGASQNNTIKFADVPNLGVEVLRGPTHDGLGEYYREMITESDEEPVDVAQVLRDKKVDVLVSYLPVGSEEADKAYAQAAMDAGVAFVNCLPVFIASDPEWAQKFRDAGVPIIGDDIKSQVGATITHRVLARLFEDRGVRLDRTYQLNVGGNMDFMNMLQRSRLESKKISKTRAVTSVVPHEMDPHNVHIGPSDYVAWLDDRKFAFVRLEGTTFGDVPLSLEYKLQVWDSPNSAGIVIDAVRAAKIALDRGLAGPVLAPSSYFMKSPAVQHEDTEARQLVEAFIKGDVEANEEELNADVAAAKAAGKDVWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVM3</accession>
    <name>B8DVM3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219298.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0222"/>
    <dbReference type="EnsemblBacteria" id="ACL28524">
        <property type="protein sequence ID" value="ACL28524"/>
        <property type="gene ID" value="BLA_0222"/>
    </dbReference>
    <dbReference type="GeneID" id="66532596"/>
    <dbReference type="KEGG" id="bla:BLA_0222"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.234"/>
    <dbReference type="HOGENOM" id="CLU_870617_0_0_11"/>
    <dbReference type="OMA" id="NDAYDTM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="314" mass="34615" checksum="D1DB65844D03FBCF" modified="2009-03-03" version="1">MTFNDEHAVEQVASLPAMKTAVRSGTDLTELWPLTTAERMDNDAKYAENLQVRLTLTMARVLVGTTEVTLPDAEFVYEGADAIPGRPQEVVDALLAANDAYEQLNPYSDSHDFSLLFEAAETLTAGWSEATQKQLGEILDDCTAYIHDTDQKRVTGLDHRFAVVLVTFAQMLRVLRSQIIANLGSDSPHTGGASSDRVRHLERVALPLLPFINEFAETLGVPRICVTADQWHGLLAAFATPNGDDDSADSARVLAESLLPLAAAEWRKHREDILWDPAEAKRAAKEEDERKNKEALAAKFAHIKDDPSKPEVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVN5</accession>
    <name>B8DVN5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipid/glycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268317.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0234"/>
    <dbReference type="EnsemblBacteria" id="ACL28536">
        <property type="protein sequence ID" value="ACL28536"/>
        <property type="gene ID" value="BLA_0234"/>
    </dbReference>
    <dbReference type="GeneID" id="66532610"/>
    <dbReference type="KEGG" id="bla:BLA_0234"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.249"/>
    <dbReference type="HOGENOM" id="CLU_027938_4_1_11"/>
    <dbReference type="OMA" id="QYNTGRV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="88"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="329" mass="37173" checksum="6A0C655E60409F40" modified="2009-03-03" version="1">MVSKGKPSPRRAVKPLSDAQVRKLAAEYALVDPTRPFPIGRMEPNQREIDELNPKITHRLVEGAAKVLRASCKVRAWGLENVPVEGAYITCATHVTQFDVFVPMVAMFQMGRRPRYMAKAEMGKWPVIGKWFRAVGMQPVPRRSGKAREIEEASVQILTSNHALTIWPEGTVTRDPKKWPMSMKNGAGFIALEASRRVGHQIPLFCAVTWGAASINHWWPWPRKNVVMCYDTQLDYSDLLANMDSWGDDPPTELANELVRRVRVRMKEVMANIRGTAAPDTFYDYRIEKEVPEVPPFSDPHEIDRRAEEAEVRVGESVESADSASSHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVQ2</accession>
    <name>B8DVQ2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268356.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0251"/>
    <dbReference type="EnsemblBacteria" id="ACL28553">
        <property type="protein sequence ID" value="ACL28553"/>
        <property type="gene ID" value="BLA_0251"/>
    </dbReference>
    <dbReference type="GeneID" id="66532626"/>
    <dbReference type="KEGG" id="bla:BLA_0251"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.266"/>
    <dbReference type="HOGENOM" id="CLU_075826_1_0_11"/>
    <dbReference type="OMA" id="FNWLMPY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004398">
        <property type="entry name" value="RNA_MeTrfase_RsmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004553">
        <property type="entry name" value="CHP00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00095">
        <property type="entry name" value="TIGR00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="191" mass="20755" checksum="31025C63E9BB7ADC" modified="2009-03-03" version="1">MRVITGRFKGVPLTTPRSETRPTTDRTKEAMFSRLDSTGILSGARVLDLFGGTGALGIEALSRGANELVVVEASGPAAKLIAHTLTALRHNPAWEESMNARIVHAKAERYAAKAKVGEPFDVVLIDPPYAFSTADCERLLGDLTARGLVARDGMIVLERSVRTERPEAPVGWQITDARDYGETAVYTYRAQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVR7</accession>
    <name>RL32_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmF</name>
        <name type="ordered locus">BLA_0266</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268380.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DVR7"/>
    <dbReference type="STRING" id="442563.BLA_0266"/>
    <dbReference type="EnsemblBacteria" id="ACL28568">
        <property type="protein sequence ID" value="ACL28568"/>
        <property type="gene ID" value="BLA_0266"/>
    </dbReference>
    <dbReference type="GeneID" id="66532641"/>
    <dbReference type="KEGG" id="bla:BLA_0266"/>
    <dbReference type="HOGENOM" id="CLU_129084_1_1_11"/>
    <dbReference type="OMA" id="HRACRHC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000195959" description="50S ribosomal protein L32">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="64" mass="7083" checksum="0C3D16ABECA71E8F" modified="2009-03-03" version="1">MALPKYKMSRANTRTRRSTWKAKAAQTITCPNCGAPTLAHVACPSCGSYRGRVYREAIRSAHTK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVU0</accession>
    <name>RL27_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmA</name>
        <name type="ordered locus">BLA_0289</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268424.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DVU0"/>
    <dbReference type="SMR" id="B8DVU0"/>
    <dbReference type="STRING" id="442563.BLA_0289"/>
    <dbReference type="EnsemblBacteria" id="ACL28591">
        <property type="protein sequence ID" value="ACL28591"/>
        <property type="gene ID" value="BLA_0289"/>
    </dbReference>
    <dbReference type="GeneID" id="66532666"/>
    <dbReference type="KEGG" id="bla:BLA_0289"/>
    <dbReference type="HOGENOM" id="CLU_095424_4_0_11"/>
    <dbReference type="OMA" id="GKDHTLH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_L27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000146509" description="50S ribosomal protein L27">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="83" mass="8906" checksum="8CFA9F402872C345" modified="2009-03-03" version="1">MAHKKGASSSRNGRDSNPQYLGVKKFGGEAVVAGNIIVRQRGTKFHAGKNVGVGKDHTLFALADGNVQFGVRRDRKVVDVVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVY3</accession>
    <name>B8DVY3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable solute binding protein of ABC transporter system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0332"/>
    <dbReference type="EnsemblBacteria" id="ACL28634">
        <property type="protein sequence ID" value="ACL28634"/>
        <property type="gene ID" value="BLA_0332"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0332"/>
    <dbReference type="HOGENOM" id="CLU_016838_0_1_11"/>
    <dbReference type="OMA" id="LTEQMPK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870525" evidence="1">
        <location>
            <begin position="30"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="302" mass="32567" checksum="A42C85C1DDAAA444" modified="2009-03-03" version="1">MKRLLRTLTILLAALATIFAVAGCSNSKAGDTQIDKEKVITVIASTNVWGSVAKQLGGQYVDVTSILNNTGTDAHDYEPSTNDISKFQHAQVAILNGAGYDEWAAKAAGQSKAIVIDAAAAGGKKTGDNPHVWFSAAVRNKTADEITAAYIKLMPSEKAEFEKLNKDWHTEEDDLEAQLQTVAQADGKMPYGAIESVGDYLAQDMGMTDVTPKGYKNATSNESEPTASDIKSFTEALKKGDMKMLIANSQEKSQLSDQLTDAADSGNIPVVDITEQMPSQYKTLNEWLKAIAEQIQATQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVZ6</accession>
    <name>B8DVZ6_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber evidence="17">1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">murB</name>
        <name evidence="19" type="ordered locus">BLA_0345</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 17">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 17">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 17">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 17">Belongs to the MurB family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98" evidence="17"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0345"/>
    <dbReference type="EnsemblBacteria" id="ACL28647">
        <property type="protein sequence ID" value="ACL28647"/>
        <property type="gene ID" value="BLA_0345"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0345"/>
    <dbReference type="HOGENOM" id="CLU_035304_0_1_11"/>
    <dbReference type="OMA" id="MQNIGAY"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.78.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00037">
        <property type="entry name" value="MurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003170">
        <property type="entry name" value="MurB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011601">
        <property type="entry name" value="MurB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036635">
        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21071">
        <property type="entry name" value="PTHR21071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 17" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 17" id="KW-0132">Cell division</keyword>
    <keyword evidence="12 17" id="KW-0133">Cell shape</keyword>
    <keyword evidence="16 17" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 17" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 17" id="KW-0274">FAD</keyword>
    <keyword evidence="9 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 17" id="KW-0521">NADP</keyword>
    <keyword evidence="14 17 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13 17" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="18">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="active site" evidence="17">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="active site" evidence="17">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ACL28647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="372" mass="40214" checksum="8E368C06303BE6AF" modified="2009-03-03" version="1">MIGGGSNMLASDDEFHGVVIRDARRNIIVPDEAAPVEGGDYTVHVNAEAGVNWDDLVQFCVERGLEGLEGLSGIPGTVGASVVQNIGAYGQEVASAVESVEVWDREEKKTLDMSNVDMQFGYRFSLLKRSMYKAPGVPNAQYYPTPRYIVLSVTFALVHTGTGTVNYPQLASALNVNLHDRMPIDRIRAAVLEVRASKGMLEDATRYREPIMMGTKRADQVEAAIAAQHAFREQHDGAARDMIIDIASDTGTNSDPNRRSCGSFFMNPIISEADAARLPEDAPRFPATLPDGSTGVKTSAAWLIDHAGFHKGYKLSDDARAGLSTLHTLSITNRGGATCNDIVKLADAIRDGVRKQFGVTLIPEPVLVNVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW09</accession>
    <name>B8DW09_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aldehyde-alcohol dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">adh</name>
        <name evidence="6" type="ordered locus">BLA_0358</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268561.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0358"/>
    <dbReference type="EnsemblBacteria" id="ACL28660">
        <property type="protein sequence ID" value="ACL28660"/>
        <property type="gene ID" value="BLA_0358"/>
    </dbReference>
    <dbReference type="GeneID" id="66532741"/>
    <dbReference type="KEGG" id="bla:BLA_0358"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.384"/>
    <dbReference type="HOGENOM" id="CLU_007207_1_0_11"/>
    <dbReference type="OMA" id="QWFKVPP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008774">
        <property type="term" value="F:acetaldehyde dehydrogenase (acetylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08178">
        <property type="entry name" value="AAD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034789">
        <property type="entry name" value="AAD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012079">
        <property type="entry name" value="Bifunc_Ald-ADH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000111">
        <property type="entry name" value="ALDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="24"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-ADH" evidence="5">
        <location>
            <begin position="481"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL28660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="915" mass="99641" checksum="383147AA7747EFA4" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW12</accession>
    <name>RS10_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsJ</name>
        <name type="ordered locus">BLA_0361</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268570.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DW12"/>
    <dbReference type="SMR" id="B8DW12"/>
    <dbReference type="STRING" id="442563.BLA_0361"/>
    <dbReference type="EnsemblBacteria" id="ACL28663">
        <property type="protein sequence ID" value="ACL28663"/>
        <property type="gene ID" value="BLA_0361"/>
    </dbReference>
    <dbReference type="GeneID" id="66532744"/>
    <dbReference type="KEGG" id="bla:BLA_0361"/>
    <dbReference type="HOGENOM" id="CLU_122625_1_3_11"/>
    <dbReference type="OMA" id="QFEIRVH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000196287" description="30S ribosomal protein S10">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <sequence length="102" mass="11570" checksum="A9A5AE9A04CBE326" modified="2009-03-03" version="1">MAGQKIRIRLKSYDHEVIDQSAKKIVETVTNAGATVVGPVPLPTEKNVYCVIRSPHKYKDSREHFEMRTHKRLIDIVDPTPKAVDSLMHIDLPADVNIEIKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW14</accession>
    <name>RL4_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplD</name>
        <name type="ordered locus">BLA_0363</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268574.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DW14"/>
    <dbReference type="SMR" id="B8DW14"/>
    <dbReference type="STRING" id="442563.BLA_0363"/>
    <dbReference type="PRIDE" id="B8DW14"/>
    <dbReference type="EnsemblBacteria" id="ACL28665">
        <property type="protein sequence ID" value="ACL28665"/>
        <property type="gene ID" value="BLA_0363"/>
    </dbReference>
    <dbReference type="GeneID" id="66532746"/>
    <dbReference type="KEGG" id="bla:BLA_0363"/>
    <dbReference type="HOGENOM" id="CLU_041575_5_0_11"/>
    <dbReference type="OMA" id="PQVHILE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000165987" description="50S ribosomal protein L4">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="218" mass="23446" checksum="82A78B42BC984BB3" modified="2009-03-03" version="1">MANVTLNVTDNNGKEAGTLEAPEALFGFTAEEVQAHVPLIHQVVVAQRAAARQGTHAVKNRGAVSGGGRKPWKQKGTGRARQGSIRAPQWYHGGVAHGPVPRDYSQRTPKKMKAAALRYALSDRANNGRVAVVDFQLDAPSTKKAIAALAPVVADNFTTVVLSRDNVNEWLSVRNIPTVYPIFADQLNTYDVITAQYVVFSKDGLEAFVAAKTAAKEA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW22</accession>
    <name>RS17_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsQ</name>
        <name type="ordered locus">BLA_0371</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268589.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DW22"/>
    <dbReference type="SMR" id="B8DW22"/>
    <dbReference type="STRING" id="442563.BLA_0371"/>
    <dbReference type="EnsemblBacteria" id="ACL28673">
        <property type="protein sequence ID" value="ACL28673"/>
        <property type="gene ID" value="BLA_0371"/>
    </dbReference>
    <dbReference type="GeneID" id="66532754"/>
    <dbReference type="KEGG" id="bla:BLA_0371"/>
    <dbReference type="HOGENOM" id="CLU_073626_1_0_11"/>
    <dbReference type="OMA" id="HPMYGKF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000166461" description="30S ribosomal protein S17">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <sequence length="86" mass="10080" checksum="2A4D049F89A3BAB0" modified="2009-03-03" version="1">MAEERNFRKVRRGYVVSDKMDKTISVELELRTTHPLYGKVVRSTRTVKAHDENNQAHVGDLVSIMETRPLSKTKRWRLDSIIERAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW37</accession>
    <name>RS11_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsK</name>
        <name type="ordered locus">BLA_0386</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268616.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DW37"/>
    <dbReference type="SMR" id="B8DW37"/>
    <dbReference type="STRING" id="442563.BLA_0386"/>
    <dbReference type="EnsemblBacteria" id="ACL28688">
        <property type="protein sequence ID" value="ACL28688"/>
        <property type="gene ID" value="BLA_0386"/>
    </dbReference>
    <dbReference type="GeneID" id="66532769"/>
    <dbReference type="KEGG" id="bla:BLA_0386"/>
    <dbReference type="HOGENOM" id="CLU_072439_5_0_11"/>
    <dbReference type="OMA" id="KWGVAHI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019981">
        <property type="entry name" value="Ribosomal_S11_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03632">
        <property type="entry name" value="uS11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000165531" description="30S ribosomal protein S11">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <sequence length="132" mass="13975" checksum="2FBC8D9321D0ABB8" modified="2009-03-03" version="1">MAAQKQAARKTRRRDRKSIPVGQAHIKSTFNNTIISITDPSGAVVSWASGGDVGFKGSRKSTPYAAGMAAESAARKAMEHGVKKVDVFVKGPGSGRETAIRSLQSAGLEVGSITDVTPQAFNGVRPPKRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW41</accession>
    <name>B8DW41_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268624.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0390"/>
    <dbReference type="EnsemblBacteria" id="ACL28692">
        <property type="protein sequence ID" value="ACL28692"/>
        <property type="gene ID" value="BLA_0390"/>
    </dbReference>
    <dbReference type="GeneID" id="66532774"/>
    <dbReference type="KEGG" id="bla:BLA_0390"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.418"/>
    <dbReference type="HOGENOM" id="CLU_074299_0_0_11"/>
    <dbReference type="OMA" id="IEMDCAR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867654" evidence="1">
        <location>
            <begin position="32"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="303" mass="32733" checksum="7C2632A05312A74D" modified="2009-03-03" version="1">MQTRHRFLSVCARTVAVALTTLAFVGVTACSAPRIAGRSEQEQELGTCERFLETAQSYSNTMGDANIPLYLRYFTASLAQHDWLNVALQCPSQFGDATMRSAQAQHFTRLAANHFGFAYAPLTVTKLDTVDSLDLPGEALATIALAEDRAGFAAEVLAGRYDSFTPTSANTSSDAEFVRRLASNATLLTMSDNHKEAAARLTMLSKGAQDIRRKVYDTRMLTTSEVNATDPATGLRTRTPAIVEMDCAREQLQRIDDLPASDIATAQSQSSDALLQLSLLIATHAVTAFGLGYPSADYALFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW54</accession>
    <name>B8DW54_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pgm</name>
        <name evidence="13" type="ordered locus">BLA_0403</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268650.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0403"/>
    <dbReference type="EnsemblBacteria" id="ACL28705">
        <property type="protein sequence ID" value="ACL28705"/>
        <property type="gene ID" value="BLA_0403"/>
    </dbReference>
    <dbReference type="GeneID" id="66532787"/>
    <dbReference type="KEGG" id="bla:BLA_0403"/>
    <dbReference type="HOGENOM" id="CLU_016950_8_1_11"/>
    <dbReference type="OMA" id="DIYKIYA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05801">
        <property type="entry name" value="PGM_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005852">
        <property type="entry name" value="PGM_a-D-Glc-sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PTHR22573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01132">
        <property type="entry name" value="pgm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="10">
        <location>
            <begin position="39"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="11">
        <location>
            <begin position="216"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="12">
        <location>
            <begin position="332"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="9">
        <location>
            <begin position="498"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACL28705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="558" mass="60439" checksum="9A71464805A8093E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW83</accession>
    <name>B8DW83_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">OsmC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268719.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0433"/>
    <dbReference type="EnsemblBacteria" id="ACL28734">
        <property type="protein sequence ID" value="ACL28734"/>
        <property type="gene ID" value="BLA_0433"/>
    </dbReference>
    <dbReference type="GeneID" id="66532818"/>
    <dbReference type="KEGG" id="bla:BLA_0433"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.462"/>
    <dbReference type="HOGENOM" id="CLU_114057_0_0_11"/>
    <dbReference type="OMA" id="TELWVER"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="137" mass="15086" checksum="51FB7AE378C26C75" modified="2009-03-03" version="1">MSKRIWVERNKDGSWDAFSDDGAHIKFGKGRGQFTPGDLMKIALAGCAALSSNFAIESTLGEGKGAKIVVDGTYDADNDSYINFNETLMIDATDADLSPEDVEKLKKRVRAHVDKGCTVKHTYEQVTPVRMDIEVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWB4</accession>
    <name>B8DWB4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable glycosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.175</ecNumber>
            <ecNumber evidence="3">2.4.1.226</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.175" evidence="3"/>
    <dbReference type="EC" id="2.4.1.226" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268787.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0466"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28765">
        <property type="protein sequence ID" value="ACL28765"/>
        <property type="gene ID" value="BLA_0466"/>
    </dbReference>
    <dbReference type="GeneID" id="66532851"/>
    <dbReference type="KEGG" id="bla:BLA_0466"/>
    <dbReference type="HOGENOM" id="CLU_025996_17_0_11"/>
    <dbReference type="OMA" id="AQVHNDM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047238">
        <property type="term" value="F:glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050510">
        <property type="term" value="F:N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="341" mass="38946" checksum="83086C44BC663998" modified="2009-03-03" version="1">MLKVSIIIPAWNEKERIVDCLDNATRQTVMPHEVLVVDNRSTDHTVEIVERYIAEHPDLPVKLLHQDEEQGLIPTRNYGLNHATGDILGRVDADCMLKPDWVEVVRGIFTEDAEAMGATGPVTYYDMPAHKIALRGDDSVRRHTYRADGGQVLLFGSNMALRASAWKLIHDEVCLDKEDVMHEDIDISLHLLGRGLKTVYSGRMICGISARRMDTSFKSFRNYMRRFKNTFAAHPEHWRNHKSERTLYLMYPWLHAMFPIYRQYLESKDINPAVRIWFREQAKLARKEGDPLADLPGIEKFVEETPTDIPGLEEIDENTAFDPDGAPQSEDSSITGTTTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWG0</accession>
    <name>B8DWG0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CRISPR-associated HD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BLA_0512</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0512"/>
    <dbReference type="EnsemblBacteria" id="ACL28811">
        <property type="protein sequence ID" value="ACL28811"/>
        <property type="gene ID" value="BLA_0512"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0512"/>
    <dbReference type="HOGENOM" id="CLU_010520_0_0_11"/>
    <dbReference type="OMA" id="PDMWGSR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035011">
        <property type="entry name" value="Cas3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006483">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031:SF539">
        <property type="entry name" value="PTHR24031:SF539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51643">
        <property type="entry name" value="HD_CAS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD Cas3-type" evidence="6">
        <location>
            <begin position="812"/>
            <end position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL28811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="1007" mass="111877" checksum="E955AC3E25D0464F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWG1</accession>
    <name>B8DWG1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0513"/>
    <dbReference type="EnsemblBacteria" id="ACL28812">
        <property type="protein sequence ID" value="ACL28812"/>
        <property type="gene ID" value="BLA_0513"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0513"/>
    <dbReference type="HOGENOM" id="CLU_053140_0_0_11"/>
    <dbReference type="OMA" id="MWDSTGP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013403">
        <property type="entry name" value="CRISPR-assoc_prot_GSU0053"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09617">
        <property type="entry name" value="Cas_GSU0053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02570">
        <property type="entry name" value="cas7_GSU0053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="397" mass="43150" checksum="2289C31414DA06A2" modified="2009-03-03" version="1">MRKLTVQDLNEAAKIGGSNALTEVTSLAPAAGMGSIVAPAKYTAGNGSTYVYEKRWVNDECVDTVLIDSRTSQANRLEDYISRAIEVGHPIFSKMPQVRVRYEMIPGDESSVRYFDDVQLPHRAVDAHIRIAEFSESDKVKYMAARNSSLEDLSAMLAISPVTVMFGCWDSTRNKNQLRIPASFNGEIYAVLADQTHESPIHRAGARIDPVAAGVHLTKNEAKKIAERIKGTMNDKKLSKFASSGDGSTIVIGAIPPSTDANALDGIAVRSITRTHVLSFSMLRAMRFGKGPEGDEAIRVLLAAALINAMVGSNAELHLRENCFLVEADEPKTVLDRRGGKHDDLEMLTLEDADELLAQAYAQAQKKAGIDWHGQIITVQGDPAVIESASAADDDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWG9</accession>
    <name>B8DWG9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Anaerobic ribonucleoside-triphosphate reductase</fullName>
            <ecNumber evidence="8">1.17.4.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nrdD</name>
        <name evidence="8" type="ordered locus">BLA_0521</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.17.4.2" evidence="8"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218231.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0521"/>
    <dbReference type="EnsemblBacteria" id="ACL28820">
        <property type="protein sequence ID" value="ACL28820"/>
        <property type="gene ID" value="BLA_0521"/>
    </dbReference>
    <dbReference type="GeneID" id="66533650"/>
    <dbReference type="KEGG" id="bla:BLA_0521"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.549"/>
    <dbReference type="HOGENOM" id="CLU_002707_2_0_11"/>
    <dbReference type="OMA" id="YSYDRVP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008998">
        <property type="term" value="F:ribonucleoside-triphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01675">
        <property type="entry name" value="RNR_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019777">
        <property type="entry name" value="Form_AcTrfase_GR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001150">
        <property type="entry name" value="Gly_radical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012833">
        <property type="entry name" value="NrdD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13597">
        <property type="entry name" value="NRDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02487">
        <property type="entry name" value="NrdD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00850">
        <property type="entry name" value="GLY_RADICAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51149">
        <property type="entry name" value="GLY_RADICAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0556">Organic radical</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="7">
        <location>
            <begin position="30"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine radical" evidence="6">
        <location>
            <begin position="662"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycine radical" evidence="5">
        <location>
            <position position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="808" mass="91618" checksum="773D29A68F1F4B9B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWL1</accession>
    <name>B8DWL1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TM2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BLA_0565</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0565"/>
    <dbReference type="EnsemblBacteria" id="ACL28862">
        <property type="protein sequence ID" value="ACL28862"/>
        <property type="gene ID" value="BLA_0565"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0565"/>
    <dbReference type="HOGENOM" id="CLU_081297_1_1_11"/>
    <dbReference type="OMA" id="HTGMGIA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="7">
        <location>
            <begin position="77"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="154" mass="16704" checksum="85C0750866391BD1" modified="2009-03-03" version="1">MSDPNGYQPQGGDQQNNGVSGAAQAPQYTQPAQNYAAPQYTQSQGGYNGQYQDPNAYAQQNYTYAQPPAAYPTYLPRNKYVAAALALFFGIFGLHNFYLGYTGKGVAQVLISVLTFGIGAIAVMIWAIVEAIQILTADYGTEHHRDARGVELQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWP5</accession>
    <name>B8DWP5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Excalibur</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218335.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0599"/>
    <dbReference type="EnsemblBacteria" id="ACL28896">
        <property type="protein sequence ID" value="ACL28896"/>
        <property type="gene ID" value="BLA_0599"/>
    </dbReference>
    <dbReference type="GeneID" id="66533729"/>
    <dbReference type="KEGG" id="bla:BLA_0599"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.631"/>
    <dbReference type="HOGENOM" id="CLU_043034_1_0_11"/>
    <dbReference type="OMA" id="DKSPDSW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="DUF1524"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="DUF1524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1524" evidence="1">
        <location>
            <begin position="94"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="242" mass="26364" checksum="FBD6F017CCC2DF1C" modified="2009-03-03" version="1">MARRFKRKYGVTPLERILIILLIAVVVGATLGVILPRINNGIAEITGRYTATGTAAETLNKLAVVDRPNGDGYDRDLFGFRETDDDGNGCDVREDILARDLTDVAYVTRNGCKVKSGVLNDPYTGKVIHFTRGQNTSAAVQIDHVVALQNAWQSGAKDWNARKRMQFANDPYNLLAVDGPANQGKGSASAAYWLPTNASYRCDYVARQIGVKDKYGLSVTSSEKRAMQSVLHGCPGQEIPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWQ7</accession>
    <name>B8DWQ7_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homoserine kinase</fullName>
            <shortName evidence="5">HK</shortName>
            <shortName evidence="5">HSK</shortName>
            <ecNumber evidence="5">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">thrB</name>
        <name evidence="8" type="ordered locus">BLA_0615</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="5"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219201.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0615"/>
    <dbReference type="EnsemblBacteria" id="ACL28908">
        <property type="protein sequence ID" value="ACL28908"/>
        <property type="gene ID" value="BLA_0615"/>
    </dbReference>
    <dbReference type="GeneID" id="66533746"/>
    <dbReference type="KEGG" id="bla:BLA_0615"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.646"/>
    <dbReference type="HOGENOM" id="CLU_041243_0_1_11"/>
    <dbReference type="OMA" id="CANRIPH"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="6">
        <location>
            <begin position="91"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="7">
        <location>
            <begin position="240"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="327" mass="34938" checksum="79C55DF72BF9A545" modified="2009-03-03" version="1">MDPVTRKVHVRVPATSANLGSGFDTVGLALDYHDELEFTLSSDPLNMAAQILITGEGENTLPRDESHLVVSTFRRACSRFGLSKCGFIMEAHNNIPQARGMGSSAEAIVAGISAAYAFSHEGELDRDVIFQYAADLEGHPDNVAPAVYGGMTVSWTEDGQSEIVQGEVVNTGFRSVNYLVDAGVRASIFVPDYELSTAQARAALLNTVPFADAVFNVSRMGLLIGAMNPSALAGEQDPNELLFTATQDKLHQSYRAPLMKPSAELIDLLREHGYAAAVSGAGPCVCVLHNGDASDDLNQIATAQLASGHWRVLHLNVDTQGVQVARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWQ8</accession>
    <name>B8DWQ8_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 17">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="6 17">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">thrA</name>
        <name evidence="20" type="ordered locus">BLA_0616</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH</text>
            <dbReference type="Rhea" id="RHEA:15757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 17">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="6 17"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219200.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0616"/>
    <dbReference type="EnsemblBacteria" id="ACL28909">
        <property type="protein sequence ID" value="ACL28909"/>
        <property type="gene ID" value="BLA_0616"/>
    </dbReference>
    <dbReference type="GeneID" id="66533747"/>
    <dbReference type="KEGG" id="bla:BLA_0616"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.647"/>
    <dbReference type="HOGENOM" id="CLU_009116_1_0_11"/>
    <dbReference type="OMA" id="LMFYGPG"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016204">
        <property type="entry name" value="HDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000098">
        <property type="entry name" value="Homoser_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14 17" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9 17" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="13 17" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="11 16 17" id="KW-0521">NADP</keyword>
    <keyword evidence="12 17 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="19">
        <location>
            <begin position="351"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="13"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ACL28909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="436" mass="46122" checksum="FEB2B8E900A1E87B" modified="2009-03-03" version="1">MAEQNAPIRVGLLGAGTVGSQTARILVEQKDELGQRIGRPLEISGIACLDPNEVDFPWIDKSLLTSDTMSVVKNADIVVELIGGTGVARTFVLEALNNGASVVTANKALLAKYGPELYKAAEDNHADIYFEAAVGGAIPIVRPLRESLVGDQVKSMLGIVNGTTNYILDEMTTKGLDFDVALKEAQEKGYAEADPTGDIEGYDAANKAAIMATLGFHTNVGIDDVTVEGITHITADDIAAATAEGKVVKLLAVVDHTEDGVSARVYPALIRNEHPLASVHGSFNAVFLHAEYADDLMFYGRGAGGAPTASAVVGDIVTVARHIASGCTGPAIRMYNDYPIAPLSSAKASFAVRFLIHDKPGVLLQVAKEFADRGISINGVNQDLKPTATEPGYDGEIQQLRLVTHMTDETTLREAVDAVCQLDSVTGDPSIIRVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWQ9</accession>
    <name>B8DWQ9_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="2">DAP decarboxylase</shortName>
            <shortName evidence="2">DAPDC</shortName>
            <ecNumber evidence="2">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">lysA</name>
        <name evidence="5" type="ordered locus">BLA_0617</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219199.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0617"/>
    <dbReference type="EnsemblBacteria" id="ACL28910">
        <property type="protein sequence ID" value="ACL28910"/>
        <property type="gene ID" value="BLA_0617"/>
    </dbReference>
    <dbReference type="GeneID" id="66533748"/>
    <dbReference type="KEGG" id="bla:BLA_0617"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.648"/>
    <dbReference type="HOGENOM" id="CLU_026444_0_1_11"/>
    <dbReference type="OMA" id="YCRSMAS"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="4">
        <location>
            <begin position="54"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="3">
        <location>
            <begin position="243"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="4">
        <location>
            <begin position="269"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="372"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="486"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="529" mass="57114" checksum="DF015C5601DA58D9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWU3</accession>
    <name>B8DWU3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Voltage-gated chloride channel family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">eriC</name>
        <name evidence="7" type="ordered locus">BLA_0651</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28944">
        <property type="protein sequence ID" value="ACL28944"/>
        <property type="gene ID" value="BLA_0651"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0651"/>
    <dbReference type="HOGENOM" id="CLU_015263_1_1_11"/>
    <dbReference type="OMA" id="NPYYRVL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="467"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="467"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL28944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="523" mass="57376" checksum="E5909EAD82DD383D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWU7</accession>
    <name>B8DWU7_BIFA0</name>
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        <recommendedName>
            <fullName evidence="5">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pyrophosphate phospho-hydrolase</fullName>
            <shortName evidence="5">PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">ppa</name>
        <name evidence="6" type="ordered locus">BLA_0655</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0655"/>
    <dbReference type="EnsemblBacteria" id="ACL28948">
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    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0655"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.683"/>
    <dbReference type="HOGENOM" id="CLU_073198_1_1_11"/>
    <dbReference type="OMA" id="DEPTFPG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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        </ligand>
    </feature>
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        </location>
    </feature>
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        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL28948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="169" mass="18984" checksum="B85FBBE65F6DA3AD" modified="2009-03-03" version="1">MAETFNVVVEIPRGSKNKYEVDQASGRVFLDRTLFTAMGYPDEYGYIDGTVGEDGDPLDALVMLTDSVFPGCVVKCRAVGLYHMVDEEGGDDKVLCVPDDVRYDNIKNIDDVSKFHKAEIKHFFEQYKALEPGKEVMPGDFFADVETAEKEIKEAKERLAKSKNEDITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWU9</accession>
    <name>B8DWU9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Possible transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0657</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0657"/>
    <dbReference type="EnsemblBacteria" id="ACL28950">
        <property type="protein sequence ID" value="ACL28950"/>
        <property type="gene ID" value="BLA_0657"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0657"/>
    <dbReference type="HOGENOM" id="CLU_000445_30_2_11"/>
    <dbReference type="OMA" id="SPMEIRN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="134"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="134"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="255" mass="27976" checksum="6766D8F40C45760B" modified="2009-03-03" version="1">MTDLTLMTFSTDPTTVLPSLTLLSHRVRVLPMDASSLVRMPENTILLLDARDDLASAKTLCRLLHASGLSTPIVLILTEGGFTVVNGEWGVSDVIVNTASPAEVEGRLRLVTERVATYNVMPNALANSGPEDEDGLIRSGDLVVDTNGYTANLRGVPIDLAYKEFELLKYLVQHPGRVFTRAQLLQEVWGYDYYGGTRTVDVHVRRLRAKLGGEYEHLIGTVRNVGYRFDPPEEESANNTAREAAEMGSPTSADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSI7</accession>
    <name>B8DSI7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA/rRNA methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.34</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.34" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219112.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0673"/>
    <dbReference type="EnsemblBacteria" id="ACL28966">
        <property type="protein sequence ID" value="ACL28966"/>
        <property type="gene ID" value="BLA_0673"/>
    </dbReference>
    <dbReference type="GeneID" id="66533806"/>
    <dbReference type="KEGG" id="bla:BLA_0673"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.701"/>
    <dbReference type="HOGENOM" id="CLU_085947_0_0_11"/>
    <dbReference type="OMA" id="TDRYQHV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009020">
        <property type="term" value="F:tRNA (guanosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052665">
        <property type="term" value="F:tRNA (uracil-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="1">
        <location>
            <begin position="154"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="269" mass="30049" checksum="9E3C4F374D540C51" modified="2009-03-03" version="1">MHEPNPIDVLAKASGEPEFREVGVGPWAEMHLQEPRPDDPRFDAALLDEGDRRNVLDRYRYWSVEAIKADLDARGRHMFEVAVENWTHDFNIGSMVRTANAFTANRVHIVGPHKWNRKGALMTELYQHVVHHPSIRACVDDWHARIAQERTEARQRIETAQTAAQAGVLSPADAARELVYARHDLNIAQNAKVIAMDIIDGAVPMETYRFPERCLLLFGAEGPGLSKKALELADDVVYISQFGSVRSINAGAAAAVTMHAWIAQHAHIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSK1</accession>
    <name>B8DSK1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28980">
        <property type="protein sequence ID" value="ACL28980"/>
        <property type="gene ID" value="BLA_0687"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0687"/>
    <dbReference type="HOGENOM" id="CLU_3363514_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="35" mass="4020" checksum="A4373C001D930B48" modified="2009-03-03" version="1">MFNRWESTTTALDKLMMETAQGAQQDSNDHGNLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSN3</accession>
    <name>B8DSN3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218724.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29012">
        <property type="protein sequence ID" value="ACL29012"/>
        <property type="gene ID" value="BLA_0719"/>
    </dbReference>
    <dbReference type="GeneID" id="66533480"/>
    <dbReference type="KEGG" id="bla:BLA_0719"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.750"/>
    <dbReference type="HOGENOM" id="CLU_1233059_0_0_11"/>
    <dbReference type="OMA" id="MDMTKPT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="224" mass="24913" checksum="902C56BCC3D1237E" modified="2009-03-03" version="1">MTKPTDSPAAKLPMPRGFKLFIALAVLMVVGAAISLFDKSEFYADVFIEISVFCVFLAGFFTNTRTLQFAYLVGANIYVIVCLGAFSTVFFTKMNQGVGVLLIIQIIFSCLNLVPIIIYHLTDREFFYTYQRQLIYPTLFFVFVLLGHLPGGDVLTSEVSHEIFSLIIFAQAFEIMDAIHKVGKAHHMAAYAINTQPLGTKLVPDTDDADDSEGSLDEPEDVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSN4</accession>
    <name>B8DSN4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dipeptide transport ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dppD</name>
        <name evidence="6" type="ordered locus">BLA_0720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269171.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0720"/>
    <dbReference type="EnsemblBacteria" id="ACL29013">
        <property type="protein sequence ID" value="ACL29013"/>
        <property type="gene ID" value="BLA_0720"/>
    </dbReference>
    <dbReference type="GeneID" id="66533481"/>
    <dbReference type="KEGG" id="bla:BLA_0720"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.751"/>
    <dbReference type="HOGENOM" id="CLU_000604_86_4_11"/>
    <dbReference type="OMA" id="RVCVMQR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="27"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="417"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="64"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="455"/>
            <end position="462"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="680" mass="75174" checksum="FB051C32F516DD0F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSP8</accession>
    <name>B8DSP8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobyrinic acid a,c-diamide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218702.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0734"/>
    <dbReference type="EnsemblBacteria" id="ACL29027">
        <property type="protein sequence ID" value="ACL29027"/>
        <property type="gene ID" value="BLA_0734"/>
    </dbReference>
    <dbReference type="GeneID" id="66533495"/>
    <dbReference type="KEGG" id="bla:BLA_0734"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.765"/>
    <dbReference type="HOGENOM" id="CLU_037612_1_0_11"/>
    <dbReference type="OMA" id="CEFFALR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="26"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="279" mass="30563" checksum="BD19036814D0BCAB" modified="2009-03-03" version="1">MPTDLLGREYETFPVPEPLRQHGPARVIAMCNQKGGVGKTTSSINIAGALAQYGRRVLIVDFDPQGAATVGLGINANALENTIYTALFNPRMDVHEVIQHTKFDGLDIIPANIDLSAAEVQLVTEVGREQILASVLRPIINEYDAIIIDCQPSLGLLTVNALTAADGVIIPVAAEFFALRGVALLMQSIEKVQSRINPSLEIYGVLVTMFTRTLHSDEVLQRIYEAFGDKVFHSVISRSIKLPDANVAAAPITFFAHNHKTAKEYREVAREMIYRDIVA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSS1</accession>
    <name>DTD_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-aminoacyl-tRNA deacylase</fullName>
            <shortName evidence="1">DTD</shortName>
            <ecNumber evidence="1">3.1.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gly-tRNA(Ala) deacylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dtd</name>
        <name type="ordered locus">BLA_0757</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DTD family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218676.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DSS1"/>
    <dbReference type="SMR" id="B8DSS1"/>
    <dbReference type="STRING" id="442563.BLA_0757"/>
    <dbReference type="EnsemblBacteria" id="ACL29050">
        <property type="protein sequence ID" value="ACL29050"/>
        <property type="gene ID" value="BLA_0757"/>
    </dbReference>
    <dbReference type="GeneID" id="66533517"/>
    <dbReference type="KEGG" id="bla:BLA_0757"/>
    <dbReference type="HOGENOM" id="CLU_076901_1_0_11"/>
    <dbReference type="OMA" id="GVFQAHM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043908">
        <property type="term" value="F:Ser(Gly)-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00563">
        <property type="entry name" value="Dtyr_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="PTHR10472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="SSF69500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00256">
        <property type="entry name" value="TIGR00256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_1000146184" description="D-aminoacyl-tRNA deacylase">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Gly-cisPro motif, important for rejection of L-amino acids" evidence="1">
        <location>
            <begin position="146"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00518"/>
        </source>
    </evidence>
    <sequence length="159" mass="17479" checksum="B5AF38B8ADABB562" modified="2009-03-03" version="1">MRIVLQKVSHAGVTVTDEAIGELDTTFTEQTIAAGYVLLVGVSDADGTRQIDWLAHKISNLRVFEDEQGKMNLSIHDVGGSILSISQFTLFADTRKGNRPSFVRAGKPEHAERVWLEFNEALRAQGLQVKEGRFGAHMNVSLVNDGPVTILFDTEELGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSS3</accession>
    <name>B8DSS3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619826.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29052">
        <property type="protein sequence ID" value="ACL29052"/>
        <property type="gene ID" value="BLA_0759"/>
    </dbReference>
    <dbReference type="GeneID" id="66533519"/>
    <dbReference type="KEGG" id="bla:BLA_0759"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.790"/>
    <dbReference type="HOGENOM" id="CLU_1253918_0_0_11"/>
    <dbReference type="OMA" id="HMETREI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="218" mass="24613" checksum="FE52DAA056BC742F" modified="2009-03-03" version="1">METREIAPLLDRRVKIYDRSLNMSTVVDIAEDVDAPARFSVTDIPVEGKEGLMLALDINYSGFPRDEYDVIGMRLYSTDPARTWIINANLLRALRIEDCKNYAVSLVLLRYRPGTPISDFDYMPYNFWNDLHYVAQAREESGSLDLKAFARLYSVATKIMKNPREVLAGGFGVSKPAVAKWAAKARAEGLYTAYTPAEKDRLRAAEIKALNEPIPDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8DST8</accession>
    <name>B8DST8_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">UDP-N-acetylmuramate--L-alanine ligase</fullName>
            <ecNumber evidence="4 11">6.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">UDP-N-acetylmuramoyl-L-alanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 15" type="primary">murC</name>
        <name evidence="15" type="ordered locus">BLA_0775</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine</text>
            <dbReference type="Rhea" id="RHEA:23372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.8" evidence="4 11"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619829.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0775"/>
    <dbReference type="EnsemblBacteria" id="ACL29067">
        <property type="protein sequence ID" value="ACL29067"/>
        <property type="gene ID" value="BLA_0775"/>
    </dbReference>
    <dbReference type="GeneID" id="66533537"/>
    <dbReference type="KEGG" id="bla:BLA_0775"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.808"/>
    <dbReference type="HOGENOM" id="CLU_028104_2_1_11"/>
    <dbReference type="OMA" id="DITYQLR"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008763">
        <property type="term" value="F:UDP-N-acetylmuramate-L-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00046">
        <property type="entry name" value="MurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005758">
        <property type="entry name" value="UDP-N-AcMur_Ala_ligase_MurC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01082">
        <property type="entry name" value="murC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 11" id="KW-0133">Cell shape</keyword>
    <keyword evidence="10 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="12">
        <location>
            <begin position="40"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="14">
        <location>
            <begin position="142"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="13">
        <location>
            <begin position="369"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="144"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ACL29067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="525" mass="55621" checksum="72B359F8DEFA1433" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSW1</accession>
    <name>HIS4_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="1">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisA</name>
        <name type="ordered locus">BLA_0798</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218614.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DSW1"/>
    <dbReference type="SMR" id="B8DSW1"/>
    <dbReference type="STRING" id="442563.BLA_0798"/>
    <dbReference type="EnsemblBacteria" id="ACL29090">
        <property type="protein sequence ID" value="ACL29090"/>
        <property type="gene ID" value="BLA_0798"/>
    </dbReference>
    <dbReference type="GeneID" id="66533560"/>
    <dbReference type="KEGG" id="bla:BLA_0798"/>
    <dbReference type="HOGENOM" id="CLU_048577_1_1_11"/>
    <dbReference type="OMA" id="EWLHLVD"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04732">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01014">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010188">
        <property type="entry name" value="HisA/PriA_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023016">
        <property type="entry name" value="Isoase_HisA-like_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="PTHR43090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01919">
        <property type="entry name" value="hisA-trpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000148953" description="1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01014"/>
        </source>
    </evidence>
    <sequence length="242" mass="25670" checksum="B147BE460A6D871E" modified="2009-03-03" version="1">MSLTLLPAVDVRDGKAVRLRQGESGSETDYGSPLDAARTWVDAGAQWIHLVDLDAAFGTGDNRAQLREIVRQLGDKVNIEMSGGVRDDASLDAALDAGAARVNIGTAALENPEWTARVIDKYGDKVAVGLDVRGHTLAARGWVKEGGGLFETMRFLDDAGCSRYVVTDVTRDGMMSGPNIDLLREVAERTDARVTASGGISKLDDLRAIKELLPLGVDSAILGKSLYAGAFTLEEALAVANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSZ2</accession>
    <name>B8DSZ2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Potential cell surface flocculin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218576.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0829"/>
    <dbReference type="EnsemblBacteria" id="ACL29121">
        <property type="protein sequence ID" value="ACL29121"/>
        <property type="gene ID" value="BLA_0829"/>
    </dbReference>
    <dbReference type="GeneID" id="66533590"/>
    <dbReference type="KEGG" id="bla:BLA_0829"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.863"/>
    <dbReference type="HOGENOM" id="CLU_510630_0_0_11"/>
    <dbReference type="OMA" id="DYYLNAC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019932">
        <property type="entry name" value="CHP03543"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03543">
        <property type="entry name" value="divI1A_rptt_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="533" mass="56561" checksum="BE3FBDAE8734F05A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT00</accession>
    <name>B8DT00_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHP C-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0837"/>
    <dbReference type="EnsemblBacteria" id="ACL29129">
        <property type="protein sequence ID" value="ACL29129"/>
        <property type="gene ID" value="BLA_0837"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0837"/>
    <dbReference type="HOGENOM" id="CLU_067347_1_0_11"/>
    <dbReference type="OMA" id="CTWGGAT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="289" mass="31682" checksum="59BB649D5A95DFEE" modified="2009-03-03" version="1">MPTRPPQEGWDLHCHTVFSDGTRTPREMVQEAKSLGLHGVAIADHDTTAGWEEAGQASHDLHLPLMRGTEITAQDGNVSVHMLAYLYDPRNRHICDLFEKTRRSRVERTKKMVALLAKDYPISWQSVLEQTKEGSRTTIGRPHIADALVAAGVYANRNEAFADAVSTHSKYYIPTPSPSTSEVVRAVEGAGGVSVIAHAADPSRNRVLLSNEQIARLADEGLDGLEVWHRGNPEDQRARLLALAQRYHLLVTGGSDWHGAGKPNALGENLTDDATVAEIVRRGAIPLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT01</accession>
    <name>B8DT01_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">BLA_0838</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VKOR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218559.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0838"/>
    <dbReference type="EnsemblBacteria" id="ACL29130">
        <property type="protein sequence ID" value="ACL29130"/>
        <property type="gene ID" value="BLA_0838"/>
    </dbReference>
    <dbReference type="GeneID" id="66533600"/>
    <dbReference type="KEGG" id="bla:BLA_0838"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.872"/>
    <dbReference type="HOGENOM" id="CLU_082938_0_0_11"/>
    <dbReference type="OMA" id="FQWRWSI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12922">
        <property type="entry name" value="VKOR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012932">
        <property type="entry name" value="VKOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041714">
        <property type="entry name" value="VKOR_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038354">
        <property type="entry name" value="VKOR_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07884">
        <property type="entry name" value="VKOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00756">
        <property type="entry name" value="VKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="VKc" evidence="12">
        <location>
            <begin position="29"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACL29130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="222" mass="24480" checksum="342079382A6C648A" modified="2009-03-03" version="1">MERHPEQPSPPQSSTTFTDLKPHGWRNGATWTYLVMLLASGVALLVSFVLSAETLQMARHPGQSLGCDVNAVLSCSTVAQAWQSEIVKFGELSFPNAFFGIAAESVFVTIAVIGMARMTMPKWFATCTWLGSLAALAYSYWLTSQSLFVINALCPWCLVLMFATTIQFMAVSHATVTVQHLPPHASSLRTYYRLNIDLMVDAVWIVALITLILVKDGAMLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT11</accession>
    <name>B8DT11_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_0848</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218543.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0848"/>
    <dbReference type="EnsemblBacteria" id="ACL29140">
        <property type="protein sequence ID" value="ACL29140"/>
        <property type="gene ID" value="BLA_0848"/>
    </dbReference>
    <dbReference type="GeneID" id="66533610"/>
    <dbReference type="KEGG" id="bla:BLA_0848"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.884"/>
    <dbReference type="HOGENOM" id="CLU_077375_0_1_11"/>
    <dbReference type="OMA" id="MTWSEMQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="16"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="219" mass="23416" checksum="CAA4C7D0FD3168DD" modified="2009-03-03" version="1">MSETLEILQDNLGKALWDTFFMVGVATLVGVVLGTALAVLLYLTQHRLFTPNHAVNEMVGFVVNAIRSMPFLILLVVLIPLIQLLIGDPYTPTGGAIALSIAAVPFFARVAESAFQEVDEGLLEAAISTGAPLRQIIFGAIFPQALPSYIRGIVLTIISLLGYSAMVGTIGAGGIGDLAIQYGYNRYETGVLVAIVLLLIVLVQVIQWVGDRIAVRVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT12</accession>
    <name>B8DT12_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methionine import ATP-binding protein MetN 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BLA_0849</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218542.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0849"/>
    <dbReference type="EnsemblBacteria" id="ACL29141">
        <property type="protein sequence ID" value="ACL29141"/>
        <property type="gene ID" value="BLA_0849"/>
    </dbReference>
    <dbReference type="GeneID" id="66533611"/>
    <dbReference type="KEGG" id="bla:BLA_0849"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.885"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_3_11"/>
    <dbReference type="OMA" id="HIQNQPV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033232">
        <property type="term" value="F:ABC-type D-methionine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03258">
        <property type="entry name" value="ABC_MetN_methionine_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026253">
        <property type="entry name" value="ABC_MetN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041701">
        <property type="entry name" value="MetN_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018449">
        <property type="entry name" value="NIL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43166:SF5">
        <property type="entry name" value="PTHR43166:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09383">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00930">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="14"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="394" mass="42855" checksum="98EFEEB120350543" modified="2009-03-03" version="1">MGVQNTDSSTIIELNHISVTFREGGRTVEAVKDVTMHVREGEIFGIVGFSGAGKSTLVRTINLLERPTEGQVIIDGHDVTDLKGGALRELRKKIGFIFQGFNLIDNVTVGRNVEFALKAGGWPKKGRRARVEELLDIVGLAEKADSYPSSLSGGQKQRVSIARALANSPRILLCDEATSALDLETTEEILTLLKRINTELGITIVFITHQFDVAKAIFDDVAVMEQGVIVEQGTTFDVFSSPHHPTTQALVERYLGIAIPEQLVPQLPPGRLIELRYRDGGAFRPLISEVAQHHDVSINVLHGNVGYFGTQAVGTLIVLVSARQGGQQGAQIVQDAIDELAEHVHSWRELSEDLNDDLGHSVDEAFAGEAAADRLIGTYGDVNDVRTDNEEVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT17</accession>
    <name>B8DT17_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDP-galactopyranose mutase</fullName>
            <ecNumber evidence="5">5.4.99.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glf</name>
        <name evidence="5" type="ordered locus">BLA_0854</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.9" evidence="5"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219209.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0854"/>
    <dbReference type="EnsemblBacteria" id="ACL29146">
        <property type="protein sequence ID" value="ACL29146"/>
        <property type="gene ID" value="BLA_0854"/>
    </dbReference>
    <dbReference type="GeneID" id="66533834"/>
    <dbReference type="KEGG" id="bla:BLA_0854"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.891"/>
    <dbReference type="HOGENOM" id="CLU_042118_0_0_11"/>
    <dbReference type="OMA" id="INVHKYG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008767">
        <property type="term" value="F:UDP-galactopyranose mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004379">
        <property type="entry name" value="UDP-GALP_mutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015899">
        <property type="entry name" value="UDP-GalPyranose_mutase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03275">
        <property type="entry name" value="GLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00031">
        <property type="entry name" value="UDP-GALP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GLF" evidence="4">
        <location>
            <begin position="158"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="394" mass="45104" checksum="98059BA856866738" modified="2009-03-03" version="1">MTANEQNATPDLVIVGAGIFGLTIAQQAVEKLGVNVTIIDIRDHIGGNAYSYMDPETGAEIHKYGAHLFHTSNSRVWEYVNRFTKFTDYVHRVYATHDGEVFPLPINLGTINQFFRANYTPAQAKALIDEQAGELAGTDPANLNDQGISLIGRPLYEAFIKNYTAKQWQTDPSELPASIIKRLPVRFNYNNRYFKDTWEGLPADGYTAWLERMIDDPRITVKLETDFFDETQPLNKRALLEAGVPVVYTGPVDRYFDYDLGELKWRTVDFKEVRYDEGDHFGCAVMNFSDADVPYTRAIEFKNFNPERAAEQNPNKTVVWEEYSRFANRDDEPYYPINTDEDKALYAQYKAKAADEPNVVFGGRLGTYAYYDMDQVFNQALISYEKQVEPLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT33</accession>
    <name>B8DT33_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BLA_0870</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0870"/>
    <dbReference type="EnsemblBacteria" id="ACL29162">
        <property type="protein sequence ID" value="ACL29162"/>
        <property type="gene ID" value="BLA_0870"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0870"/>
    <dbReference type="HOGENOM" id="CLU_060703_2_0_11"/>
    <dbReference type="OMA" id="GFAWFQK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="19"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL29162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="278" mass="32285" checksum="A6B76CA2C01EB9CD" modified="2009-03-03" version="1">MNTLSQRLKSRYGYAMTVLRGLVKTDFKMRYQGSFLGVAWSVLKPLMLFAVMYVVFAKFMRMTDGTPTYPVVLLLGISSWQFVTETVGIGLRSIVDRGDLLRKVHFPNYIVVVSASIGSLISLAINYVVILIFAIFMRVQFTWRVLWLPINVLELYIIALALALILSTFYVFYRDVLHIWEVLQQIIFYAMPIIYPLSFITDKHPEYRTIANLELMNPIAQTIQDIRHNFIAPATQPTVWNTFGSWWVKMIPIAITVLLLWFGVYIFRKNSRRFAEVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT40</accession>
    <name>B8DT40_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative HD superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0877"/>
    <dbReference type="EnsemblBacteria" id="ACL29169">
        <property type="protein sequence ID" value="ACL29169"/>
        <property type="gene ID" value="BLA_0877"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0877"/>
    <dbReference type="HOGENOM" id="CLU_073842_0_0_11"/>
    <dbReference type="OMA" id="AQFARNH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="62"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="249" mass="27831" checksum="44662D7388C074B4" modified="2009-03-03" version="1">MHRKCAQSQAAYDLIHTHCQIIAQITRQLIHRQNALFMRRCTLPDDALERTGDYPTLAGERIADAIGSPEEDRFVVPPTDGVTGGMVPPRYIDVEKATIGALLHDIGTYAVLKNDGSNGEPLSFDGPRYVEHGLIGYELLLNEGYDESIAEFARNHTGCGLTREDVIDQHLPLPPADYVPVNLEQEVVMVADKYHSKSVPPKFLTASAYARKAARFGAENKQRWLELVRKYGEPDVPALAEHYHMRLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT46</accession>
    <name>B8DT46_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Probable permease protein of ABC transporter system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BLA_0883</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219246.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29175">
        <property type="protein sequence ID" value="ACL29175"/>
        <property type="gene ID" value="BLA_0883"/>
    </dbReference>
    <dbReference type="GeneID" id="66533862"/>
    <dbReference type="KEGG" id="bla:BLA_0883"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.923"/>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_11"/>
    <dbReference type="OMA" id="RVMHDLR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="39"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="353"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="387"/>
            <end position="394"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL29175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="597" mass="67723" checksum="E1236D6613770259" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT50</accession>
    <name>B8DT50_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219290.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0887"/>
    <dbReference type="EnsemblBacteria" id="ACL29179">
        <property type="protein sequence ID" value="ACL29179"/>
        <property type="gene ID" value="BLA_0887"/>
    </dbReference>
    <dbReference type="GeneID" id="66533866"/>
    <dbReference type="KEGG" id="bla:BLA_0887"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.929"/>
    <dbReference type="HOGENOM" id="CLU_150484_0_0_11"/>
    <dbReference type="OMA" id="VAVLWHI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="148" mass="16373" checksum="6A75ECE491ACCCE5" modified="2009-03-03" version="1">MDALPHARAHRPCMPARRAGMPLRAARRRHAASRTASQAPRRRSSAKRLASTLHTAHTPNKGLLHPPPPPLALTPQSASDPNTPMDALWHIARTMPPLRKWVVVNRAADANLLEYISQQGGPGVRQALELVLESLELQRSSMQRMRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT56</accession>
    <name>B8DT56_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-D-glucosideglucohydrolase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bglX</name>
        <name evidence="3" type="ordered locus">BLA_0893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0893"/>
    <dbReference type="CAZy" id="GH3">
        <property type="family name" value="Glycoside Hydrolase Family 3"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29185">
        <property type="protein sequence ID" value="ACL29185"/>
        <property type="gene ID" value="BLA_0893"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0893"/>
    <dbReference type="HOGENOM" id="CLU_004542_5_1_11"/>
    <dbReference type="OMA" id="TLITDWD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="2">
        <location>
            <begin position="724"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="807" mass="87804" checksum="CF98A7E7A52FCACB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT74</accession>
    <name>B8DT74_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Permease of ABC transporter possibly for oligosaccharides</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_0911</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0911"/>
    <dbReference type="EnsemblBacteria" id="ACL29203">
        <property type="protein sequence ID" value="ACL29203"/>
        <property type="gene ID" value="BLA_0911"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0911"/>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_11"/>
    <dbReference type="OMA" id="IVTVWQY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="93"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="307" mass="34339" checksum="5976288361ED66F8" modified="2009-03-03" version="1">MNRDMALPHSGVGRTRRGESRHAMISMAGKAIRRWWALFVLPTFVAFFIGFLVPFIYGIYLSFCSFTTVTDAKFIGWQNYARAIKDKEFLHALGFSTLMTIVTTIVINVVAFAIAYLLTKSIRGSNLFRSVFFMPNLIGGIILGYIWMLLLNGVLAHWERSLTYSAKYGFWGLVILVCWQQIGYMMIIYIAGMQSLPTDVLEAAEVDGANGRQVMFRIIIPLMMPSITVCSFLTVTNGFKLYDQNLALTNGAPQNMSEGLALNITRTFYGRIGWEGVGQAKAVLFFILVAIVALIQNKITTSKEVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT87</accession>
    <name>B8DT87_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dihydrodipicolinate reductase, N-terminus domain protein</fullName>
            <ecNumber evidence="5">1.17.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dapB</name>
        <name evidence="5" type="ordered locus">BLA_0924</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.17.1.8" evidence="5"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217579.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0924"/>
    <dbReference type="EnsemblBacteria" id="ACL29216">
        <property type="protein sequence ID" value="ACL29216"/>
        <property type="gene ID" value="BLA_0924"/>
    </dbReference>
    <dbReference type="GeneID" id="66533462"/>
    <dbReference type="KEGG" id="bla:BLA_0924"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.967"/>
    <dbReference type="HOGENOM" id="CLU_050509_1_0_11"/>
    <dbReference type="OMA" id="TIPVGKC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045760">
        <property type="entry name" value="DAP_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19328">
        <property type="entry name" value="DAP_DH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="3">
        <location>
            <begin position="9"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="DAP_DH_C" evidence="4">
        <location>
            <begin position="143"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="341" mass="36782" checksum="CA6CBB87D45706E9" modified="2009-03-03" version="1">MEPIRAIQFGCGKMAKYTVRYMHDKGMQIVGAIDVNPDVVGMDVGEFAGIGPLNVTISDDADAVLDSCDADIAVVTLFSFMDDIEPMCEACLSRGISVITTCEEAIYPWTTNPAVTNRLDRIAKENGATMVGSGMQDIFWINMVAQVAGGCNSMTKISGATSYNVEDYGLALAKAHGVGLTAEQFEEQLAHPDEVVPSYVWNSNESLVQRLGLTIKSQTQRAVPYFSDVDVYSETMGETIPAGVCIGMSAVVTTETMQGLTIETSCIGKVYGPDDGDMCDWRIEGEPDTEFHVVKPATVEHTCATMVNRIPNVLNAPAGYVTVDQLPEINHLSYPAAMYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT95</accession>
    <name>B8DT95_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217589.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0932"/>
    <dbReference type="EnsemblBacteria" id="ACL29224">
        <property type="protein sequence ID" value="ACL29224"/>
        <property type="gene ID" value="BLA_0932"/>
    </dbReference>
    <dbReference type="GeneID" id="66533454"/>
    <dbReference type="KEGG" id="bla:BLA_0932"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.975"/>
    <dbReference type="HOGENOM" id="CLU_1552299_0_0_11"/>
    <dbReference type="OMA" id="PGTARMR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="104"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="171" mass="19290" checksum="E60A6E9E70ABB129" modified="2009-03-03" version="1">MEQMTMVNEQVEVKSVETPEQVRSGSARMRELTPAQRRAVMFAQQQVLRARAAKKAKDEHQAALARMWQEEDAETARPRAMVHRRETVGEVKEVSLRKAIGHVLRDLRTRDHKTLREVSEKAGVSLGYLSEVERGQKEASSELLASISESLGLSTSQMLRMVADYLDSVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTA6</accession>
    <name>B8DTA6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217606.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0943"/>
    <dbReference type="EnsemblBacteria" id="ACL29235">
        <property type="protein sequence ID" value="ACL29235"/>
        <property type="gene ID" value="BLA_0943"/>
    </dbReference>
    <dbReference type="GeneID" id="66533443"/>
    <dbReference type="KEGG" id="bla:BLA_0943"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.986"/>
    <dbReference type="HOGENOM" id="CLU_1018045_0_0_11"/>
    <dbReference type="OMA" id="IRDALIM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="234" mass="26024" checksum="E4C1BA5679DFF022" modified="2009-03-03" version="1">MVSNNEHNEEAEMNREDGGIAGLGMHPLPVARLGGMRREYFERMTDIGTASAAARWIADLLPPWLTWLREPEMKPQDLDDEVQLMLVTGFNISLAVRDAIIMTVVADESQWDEGVISRFAAHPHDKDVAQSMSAMLTAAFEEPESDERRCVRVVELLHTMSGRLPAECTRQLRAVRAYLKWWRGDESALHDALGVLEEDERVTLAAIVAAAVTRHVYPAHAGRAETEDAPIAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTC7</accession>
    <name>B8DTC7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619891.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0966"/>
    <dbReference type="EnsemblBacteria" id="ACL29256">
        <property type="protein sequence ID" value="ACL29256"/>
        <property type="gene ID" value="BLA_0966"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0966"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1009"/>
    <dbReference type="HOGENOM" id="CLU_191180_0_1_11"/>
    <dbReference type="OMA" id="HRMGPYK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="66" mass="7711" checksum="CC61C0669A673E24" modified="2009-03-03" version="1">MTEPQEWYYNTVTGEVELGPQSPMQNRLGLGLSGEDAEKALEIAKKRNKKWEDQDRDWNNWGTDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTF0</accession>
    <name>B8DTF0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Possible transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BLA_0989</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217665.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0989"/>
    <dbReference type="EnsemblBacteria" id="ACL29279">
        <property type="protein sequence ID" value="ACL29279"/>
        <property type="gene ID" value="BLA_0989"/>
    </dbReference>
    <dbReference type="GeneID" id="66533398"/>
    <dbReference type="KEGG" id="bla:BLA_0989"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1032"/>
    <dbReference type="HOGENOM" id="CLU_012341_1_0_11"/>
    <dbReference type="OMA" id="VFPFEWG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870483" evidence="7">
        <location>
            <begin position="32"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="499"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="736"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="786"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="831"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="21"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="296"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="769"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL29279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="868" mass="90740" checksum="FB844A6861C2039E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTF5</accession>
    <name>B8DTF5_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding ATPase YchF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ychF</name>
        <name evidence="7" type="ordered locus">BLA_0994</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217671.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0994"/>
    <dbReference type="EnsemblBacteria" id="ACL29284">
        <property type="protein sequence ID" value="ACL29284"/>
        <property type="gene ID" value="BLA_0994"/>
    </dbReference>
    <dbReference type="GeneID" id="66533393"/>
    <dbReference type="KEGG" id="bla:BLA_0994"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1037"/>
    <dbReference type="HOGENOM" id="CLU_018395_0_1_11"/>
    <dbReference type="OMA" id="VLRCFDN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00092">
        <property type="entry name" value="TIGR00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="3"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="6">
        <location>
            <begin position="276"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="364" mass="40120" checksum="7112C62B875E009B" modified="2009-03-03" version="1">MSLTIGIVGLPNVGKSTMFNALTRNNVLAENYPFATIEPNTGIVPLPDKRLPVLAELVHTDKIVPATVTFVDIAGIVKGASEGEGLGNKFLANIREADAICEVVRAFEDDDIIHVNGHVDPDDDIDTINTELILADLQTIDNALPKLEKDLRGKKIEKSYMDAVLKAKEILESGRTIDQAAQAGEIKKEEVYDLHLLTAKPFIYVFNVDDSELQNEELKQRLAKSVAPAPAIFLNAQFESELTELDEADAREMLEDAGLDESGLDQLARVGFDILGLQTFLTAGEKEVRAWQIHKGWTAPQAAGVIHTDFEKGFIKAEVVSYDDFVEAYGSMAKIKEEGKLRLEGKDYVMQDGDIVEFKFNVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTH3</accession>
    <name>B8DTH3_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FeoA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619907.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1012"/>
    <dbReference type="EnsemblBacteria" id="ACL29302">
        <property type="protein sequence ID" value="ACL29302"/>
        <property type="gene ID" value="BLA_1012"/>
    </dbReference>
    <dbReference type="GeneID" id="66533375"/>
    <dbReference type="KEGG" id="bla:BLA_1012"/>
    <dbReference type="HOGENOM" id="CLU_150646_11_0_11"/>
    <dbReference type="OMA" id="FCIKTLD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="2">
        <location>
            <begin position="10"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="88" mass="9616" checksum="AA68B52F887B83C7" modified="2009-03-03" version="1">MSSTSPSHSLTLETCPLNTDVVIRAIALDERHRFRMLELGLRDGVTVRVVQKSNFGGRVVAKGTERIALDESTARSIHVTTTTAQTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTH5</accession>
    <name>B8DTH5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleoside 2-deoxyribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217694.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1014"/>
    <dbReference type="EnsemblBacteria" id="ACL29304">
        <property type="protein sequence ID" value="ACL29304"/>
        <property type="gene ID" value="BLA_1014"/>
    </dbReference>
    <dbReference type="GeneID" id="66533373"/>
    <dbReference type="KEGG" id="bla:BLA_1014"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1059"/>
    <dbReference type="HOGENOM" id="CLU_132496_0_0_11"/>
    <dbReference type="OMA" id="MIAQSVE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007710">
        <property type="entry name" value="Nucleoside_deoxyribTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05014">
        <property type="entry name" value="Nuc_deoxyrib_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="154" mass="16749" checksum="B5FD894196D4FBCB" modified="2009-03-03" version="1">MSNFDSNETIQFTSSKPVYDFYVAGPYETAEQVESMERLEKVLNDRGMSVYRPRFAMDVNVSGPQAVFANRIAAIANSRAVIANMDDNDAGAVFALAYGYALGKPVYAYCEGILPNGRISLMVDQAATAVLDGPADLESLLDSGRVKPLDLDQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTI8</accession>
    <name>B8DTI8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BLA_1029</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217714.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1029"/>
    <dbReference type="EnsemblBacteria" id="ACL29317">
        <property type="protein sequence ID" value="ACL29317"/>
        <property type="gene ID" value="BLA_1029"/>
    </dbReference>
    <dbReference type="GeneID" id="66533360"/>
    <dbReference type="KEGG" id="bla:BLA_1029"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1075"/>
    <dbReference type="HOGENOM" id="CLU_046113_1_2_11"/>
    <dbReference type="OMA" id="LRWHPGY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="110"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="302" mass="32243" checksum="95ECFED65FFB8855" modified="2009-03-03" version="1">MTQSATNESGNPYRDASSMGTTGAPARSAAYAVPAAEHTKTASRIGTRFIPWHHGRAPRFCALWASTVLIVLAWALATGGPAHNRSLPSPGEVWQALLALHSEGLLLPSIGVSLYRVSLGVALGVVTAVPAGIIAGSSTIGHAIMDKPIHMLRAVPFPALSPLLIVLLGIGETMKVALIAIGAFALIYVNVRDGVRGIDPKLLELAQAYHLPKRTVFAKILLRGTLPRFMTGLRFALTVSWIALVTCETVNSSAGIGYILSRSQQFYRTDQMVLCIVLYAFLGLFSEWLVGALERLVVPCAH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTL4</accession>
    <name>RF1_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptide chain release factor 1</fullName>
            <shortName evidence="1">RF-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">prfA</name>
        <name type="ordered locus">BLA_1055</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Methylated by PrmC. Methylation increases the termination efficiency of RF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218748.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DTL4"/>
    <dbReference type="SMR" id="B8DTL4"/>
    <dbReference type="STRING" id="442563.BLA_1055"/>
    <dbReference type="EnsemblBacteria" id="ACL29343">
        <property type="protein sequence ID" value="ACL29343"/>
        <property type="gene ID" value="BLA_1055"/>
    </dbReference>
    <dbReference type="GeneID" id="66532884"/>
    <dbReference type="KEGG" id="bla:BLA_1055"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1103"/>
    <dbReference type="HOGENOM" id="CLU_036856_0_1_11"/>
    <dbReference type="OMA" id="ISDHRVG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000193470" description="Peptide chain release factor 1">
        <location>
            <begin position="1"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="1">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00093"/>
        </source>
    </evidence>
    <sequence length="365" mass="40948" checksum="78FD6734FD62C3D4" modified="2009-03-03" version="1">MASEEFPAAKTALEEYENIERQMGEQEVWSNPDKMRKLGRRQAQLGTIVNAYRTWLNIRNDLDAAQEMAGEDPDFAQEAKRLESELPEAEEKLRTALIPRDPDDARDVIMEIKAGAGGEEAALFAGDLLRMYMRYAEKRGWGVTIQSENSTELGGVKDVQMAIRAKGNPSPEEGVWASLKYEGGVHRVQRIPVTESQGRIQTSAAGVIVFPEADEDDDEIEIDPKDLKIDIFMSSGPGGQSVNTTYSAVRMTHIPTGIVVSMQDEKSQIQNRAAALRVLKSRLLAMKHEQEAAEAADMRHSQVRSLDRSERIRTYNFPENRIVDHRTNYKAYNLDAVLDGDLQAVIDSDIQADEEQRLASQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTM0</accession>
    <name>B8DTM0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted hydrolases of the HAD superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218756.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1061"/>
    <dbReference type="EnsemblBacteria" id="ACL29349">
        <property type="protein sequence ID" value="ACL29349"/>
        <property type="gene ID" value="BLA_1061"/>
    </dbReference>
    <dbReference type="GeneID" id="66532890"/>
    <dbReference type="KEGG" id="bla:BLA_1061"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1109"/>
    <dbReference type="HOGENOM" id="CLU_044146_5_1_11"/>
    <dbReference type="OMA" id="APHNNEE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="282" mass="31352" checksum="0C45C85698A6ECAE" modified="2009-03-03" version="1">MAEVEWTEIKEPQDIKLVVADMDATLLDADGQIPAGFWPMLDRLNQKGVTFVPASGRQYQTLQQMFSRSVRPMSFIAENGNIVSLDGNVIETHTVSRDLVKQVIDICDKAAETGEYNIGLVVCGLNAAYIQRTDEEFIAEVSKYYAKVEPVNNLREVLDYVDEKFLKLAIFDFEPAEPMAKDLLAGIEQPYEYVLSGKHWADIMDSRVSKGDGVVVLQKALGVGVDETAVFGDYLNDVPMFEHARYSFAVANAHPQVRAAAAYIAPANTEEGVIRVVDRIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTN3</accession>
    <name>B8DTN3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29362">
        <property type="protein sequence ID" value="ACL29362"/>
        <property type="gene ID" value="BLA_1074"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1074"/>
    <dbReference type="HOGENOM" id="CLU_3230229_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="43" mass="4771" checksum="5BD406C2239BE35E" modified="2009-03-03" version="1">MKKQDNTEGRQTRRSYNATRIVAIVVVCAMLVGFAMPLIFAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTN8</accession>
    <name>B8DTN8_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">smpB</name>
        <name evidence="4" type="ordered locus">BLA_1079</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SmpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218775.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1079"/>
    <dbReference type="EnsemblBacteria" id="ACL29367">
        <property type="protein sequence ID" value="ACL29367"/>
        <property type="gene ID" value="BLA_1079"/>
    </dbReference>
    <dbReference type="GeneID" id="66532905"/>
    <dbReference type="KEGG" id="bla:BLA_1079"/>
    <dbReference type="HOGENOM" id="CLU_108953_2_1_11"/>
    <dbReference type="OMA" id="WTNHSAR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
        <property type="term" value="P:trans-translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00086">
        <property type="entry name" value="smpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="163" mass="19026" checksum="B84E63B2E2A57BB3" modified="2009-03-03" version="1">MAKKEQSNEKMIAQNRRARHDYEIEDTYEAGLALTGTEVKSLREGRASLAESFISIDKRGEVWLEGANIPEYLNGTWNNHAPKRKRKLLLHGAQIDKLRRQIQAKGYTIVPLQLYFNEDGRAKLKIALARGKKEYDKRQALREEQDKREALRMMRYKNMHARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTR2</accession>
    <name>B8DTR2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29391">
        <property type="protein sequence ID" value="ACL29391"/>
        <property type="gene ID" value="BLA_1103"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1103"/>
    <dbReference type="HOGENOM" id="CLU_1988282_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="150" mass="16569" checksum="B9A2855934C3C26D" modified="2009-03-03" version="1">MVGEHLPPFFMIASTRSVPDSYVAMMFLPLFCVRCGVPRRGFYGLHGLPSGFTEFANGEVLAQSHCHVEVRVAAAGLWLCRVPCVVLMRGTSYLLFAAAVVVPVYCLVFWLLTGSYHPSTIAAFLLVEWLCVGVGVYMLRSVRSLDDYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTT8</accession>
    <name>B8DTT8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UMUC-like DNA-repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_1129</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619940.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1129"/>
    <dbReference type="EnsemblBacteria" id="ACL29417">
        <property type="protein sequence ID" value="ACL29417"/>
        <property type="gene ID" value="BLA_1129"/>
    </dbReference>
    <dbReference type="GeneID" id="66532953"/>
    <dbReference type="KEGG" id="bla:BLA_1129"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1183"/>
    <dbReference type="HOGENOM" id="CLU_012348_5_1_11"/>
    <dbReference type="OMA" id="FWRVGKG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="3">
        <location>
            <begin position="6"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="498" mass="54894" checksum="AF6789FA418B812A" modified="2009-03-03" version="1">MGERTYLAVDLKSFYASAECVARGLDPLDANLVVADVSRTSKTICLAVSPALKSFGLGSRARLFEVEERVGVLNEQRRLRAPGHRLAGSSVSAAQLQADPRLGIEYIAAKPRMSYYLDTSAKIYGIYLNYASKEDIHVYSVDEVFIDVTKYLKYFGCSAHELARRIVADILEQTGITATAGIGANLYLAKVAMDIVAKHIPADEDGVRIAELDERRYRELLWSHRPLTDFWRVGRGIARKLERQGIMTMGDIARCSLGRAGEYYNEDLLYRFFGVNAETLIDHAWGWEPCTIADIKAYTPENSSLSIGQVLARPYPHTQAHTVASEMADCLAQDLAAKGAVTDQVVLTVGFDRESLMDGRYLGPVGKDHYGRPVPKSVHGSCDLGRFTSSATAIRQAVVDVFERIADSRLYVRRLTVVAGRVRMLGETQTFEQPSLFEDLEGSQTQQQATADRKELSLQRTVNALRSRFGAASVIKGVNLDEGATGMERSKQIGGHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTU7</accession>
    <name>B8DTU7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218864.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29426">
        <property type="protein sequence ID" value="ACL29426"/>
        <property type="gene ID" value="BLA_1138"/>
    </dbReference>
    <dbReference type="GeneID" id="66532962"/>
    <dbReference type="KEGG" id="bla:BLA_1138"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1194"/>
    <dbReference type="HOGENOM" id="CLU_1460314_0_0_11"/>
    <dbReference type="OMA" id="GECESFN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="194" mass="21037" checksum="BF10852565D32544" modified="2009-03-03" version="1">MRSVNLLPNEGIVAQFDSVRCESPDFKGCESGELTFTTMSLIFSYTQVKVFGKDIEHTFLWALHDIKVVDGRPQLIIDKGDAHQCDILLRKGKLELRMDSHADLVTLANGINKLITGNDEDIVGAPKTFISGIASMLSDAGKEVTEAFGLRNTANPKSAESKMVSRACAGCGAPLHGRQGTSVTCEYCGRSEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTX5</accession>
    <name>B8DTX5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative proteasome component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Pup ligase/Pup deamidase family. Pup deamidase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218903.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1166"/>
    <dbReference type="EnsemblBacteria" id="ACL29454">
        <property type="protein sequence ID" value="ACL29454"/>
        <property type="gene ID" value="BLA_1166"/>
    </dbReference>
    <dbReference type="GeneID" id="66532991"/>
    <dbReference type="KEGG" id="bla:BLA_1166"/>
    <dbReference type="HOGENOM" id="CLU_040524_1_0_11"/>
    <dbReference type="OMA" id="RRFHVIT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022366">
        <property type="entry name" value="Pup_deamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004347">
        <property type="entry name" value="Pup_ligase/deamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42307">
        <property type="entry name" value="PTHR42307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03136">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03688">
        <property type="entry name" value="pupylate_PafA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="534" mass="59894" checksum="165F9C08A81FF829" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU28</accession>
    <name>B8DU28_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619969.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1219"/>
    <dbReference type="EnsemblBacteria" id="ACL29507">
        <property type="protein sequence ID" value="ACL29507"/>
        <property type="gene ID" value="BLA_1219"/>
    </dbReference>
    <dbReference type="GeneID" id="66533043"/>
    <dbReference type="KEGG" id="bla:BLA_1219"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1281"/>
    <dbReference type="HOGENOM" id="CLU_017584_4_2_11"/>
    <dbReference type="OMA" id="NPTGHFL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="55"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="387" mass="43474" checksum="249A6337716EC67D" modified="2009-03-03" version="1">MRFSSRIDVSQPNPIAACEAEAKARGVDLDKLNDSNPTAHGLAPQLLPQVYRAQPRGQMEARRRLARAIGCPDPERLYLLSSTSQAYAWLMMLLCDPGEAVLAPKPGYPLIESIARLCGVKTVEYQLQFDGSWYMDIAALRTILERDGQAGRHIRALIVINPNNPTGQYVKPSEREHLIELCREFGIALIADEVFFDYALEPFEGNRRFAGERRVLTFALDGFSKRLAAPHAKVGWIEVSGPDDDVREAMRRLDVIADDFLPMSELIAERMDDMIAELDSQHDRVQERISRNLESLHRLLDADDLGVVSVLRAEGGWNVLLRFPSFIDENELVTTMIRDNATSGQPGYFFDMEANGYLAISLLPVPDLFDAHVRLVLSAVRHCVEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU41</accession>
    <name>B8DU41_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218103.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29520">
        <property type="protein sequence ID" value="ACL29520"/>
        <property type="gene ID" value="BLA_1232"/>
    </dbReference>
    <dbReference type="GeneID" id="66533056"/>
    <dbReference type="KEGG" id="bla:BLA_1232"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1295"/>
    <dbReference type="HOGENOM" id="CLU_148495_0_0_11"/>
    <dbReference type="OMA" id="PTDYTIN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="146" mass="16239" checksum="A7CD4A79EC39B720" modified="2009-03-03" version="1">MPNGAGYTKPPQNQSNGVYFAPICVSSEGLSDAQSRKLDEDIDECKDLHVSAIDLGHQTQLGNPEFYGDPEVALIDCLHRGNLMPKDYTINKYWLQFEAYMNGTKAGSVPDDWFSFDLNDSAMLTCLASDKSPLLQTRLEAWKPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU42</accession>
    <name>B8DU42_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269077.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1233"/>
    <dbReference type="EnsemblBacteria" id="ACL29521">
        <property type="protein sequence ID" value="ACL29521"/>
        <property type="gene ID" value="BLA_1233"/>
    </dbReference>
    <dbReference type="GeneID" id="66533057"/>
    <dbReference type="KEGG" id="bla:BLA_1233"/>
    <dbReference type="HOGENOM" id="CLU_989244_0_0_11"/>
    <dbReference type="OMA" id="WLPDRAP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="284" mass="30415" checksum="F1A7CFFA1E0D6837" modified="2009-03-03" version="1">MLGMPHTVESAPASSQEYSGTQQVNVVPTIAADRQLPGNATGTVTENWMAGELRSGSRAYQVNDRTVVALHTATPLYRDLKVGDRGEDVRSLNDELSRLGYDSVPQSGEYNRNTGNGWRQLMVDAGNSDGAGEDDMNLRLSDTMWIPPDSVKVQGWSATRGSAVQAGAPLGTVPGGLVRLAIRGGKPSDEGRPLTVFGVAAPLAPGTTDITDGELLQRIAATEGYQGKSAEERAAGMDPAHAQQGDPDPTRAGRFGVRHQWDLGMHRHRHVRQSPCRTGAHHHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU44</accession>
    <name>B8DU44_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29523">
        <property type="protein sequence ID" value="ACL29523"/>
        <property type="gene ID" value="BLA_1235"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1235"/>
    <dbReference type="HOGENOM" id="CLU_2153404_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="111" mass="12233" checksum="D4C1176FC07F5267" modified="2009-03-03" version="1">MRCDYRHLIQRRLNKRNNCDWRAVISMAMAPTNVPEHMANGARQEASITDATSPMAMRAQYAQINAHALNAPNPAQTSTSVQMPSSSAGFDSPNAARRRIPVAVHAPQAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU79</accession>
    <name>B8DU79_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal silencing factor RsfS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsfS</name>
        <name evidence="3" type="ordered locus">BLA_1270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with ribosomal protein L14 (rplN).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619987.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1270"/>
    <dbReference type="EnsemblBacteria" id="ACL29558">
        <property type="protein sequence ID" value="ACL29558"/>
        <property type="gene ID" value="BLA_1270"/>
    </dbReference>
    <dbReference type="GeneID" id="66533093"/>
    <dbReference type="KEGG" id="bla:BLA_1270"/>
    <dbReference type="HOGENOM" id="CLU_092688_2_0_11"/>
    <dbReference type="OMA" id="VVHVFQK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="PTHR21043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="137" mass="15440" checksum="F8BAC1500099D6EF" modified="2009-03-03" version="1">MNALEQSINSVRVAATAADGMKAEDVVAYNVGDKLGICDLMMIASASNERQVLAIAEEVEKQLFLKDGGRKPRSREGVEEAQWVLLDYGDFIIHIMHDEARDFYNLERLWRDCEPVDLELEHPESRGIKSSDADTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU87</accession>
    <name>B8DU87_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ComEC/Rec2-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BLA_1279</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1279"/>
    <dbReference type="EnsemblBacteria" id="ACL29566">
        <property type="protein sequence ID" value="ACL29566"/>
        <property type="gene ID" value="BLA_1279"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1279"/>
    <dbReference type="HOGENOM" id="CLU_027482_0_0_11"/>
    <dbReference type="OMA" id="YDCQTDI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004477">
        <property type="entry name" value="ComEC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03772">
        <property type="entry name" value="Competence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00360">
        <property type="entry name" value="ComEC_N-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Competence" evidence="7">
        <location>
            <begin position="282"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="586" mass="63519" checksum="73E4D39A9376EE8E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUA4</accession>
    <name>EFTS_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor Ts</fullName>
            <shortName evidence="1">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tsf</name>
        <name type="ordered locus">BLA_1296</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the EF-Ts family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218011.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DUA4"/>
    <dbReference type="SMR" id="B8DUA4"/>
    <dbReference type="STRING" id="442563.BLA_1296"/>
    <dbReference type="EnsemblBacteria" id="ACL29583">
        <property type="protein sequence ID" value="ACL29583"/>
        <property type="gene ID" value="BLA_1296"/>
    </dbReference>
    <dbReference type="GeneID" id="66533122"/>
    <dbReference type="KEGG" id="bla:BLA_1296"/>
    <dbReference type="HOGENOM" id="CLU_047155_0_0_11"/>
    <dbReference type="OMA" id="DAGMMDC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000189861" description="Elongation factor Ts">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="1">
        <location>
            <begin position="84"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <sequence length="285" mass="30074" checksum="42E0CD8FB8AE9FA0" modified="2009-03-03" version="1">MAAITAALIKQVREETGAGMMDVKKALTEADGDVARAKEIIRAKGIQAAGKREGRKAQEGTIASTVIDSAAGQTGYAVELNSETDFVAKTPKFIDFADTVLADAVKAGADDIDAVLAAPSQDGTVKEAVEEASALFGEHVKVGQFAKIEGPKVEIYAHKKSVEMPPSIVAMIATDEAGAAVAHEAALQISAMGAQWLTRDDVPEDVVETERRVATEKSLAEGKPEKIVPKIVEGRLNAFFKENVLLEQAYVKDPSKTIGDLFKEVGGQALAFARLEVGKAPEADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUC4</accession>
    <name>B8DUC4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Possible CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pgsA</name>
        <name evidence="14" type="ordered locus">BLA_1316</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AD011</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217985.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1316"/>
    <dbReference type="EnsemblBacteria" id="ACL29603">
        <property type="protein sequence ID" value="ACL29603"/>
        <property type="gene ID" value="BLA_1316"/>
    </dbReference>
    <dbReference type="GeneID" id="66533141"/>
    <dbReference type="KEGG" id="bla:BLA_1316"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1378"/>
    <dbReference type="HOGENOM" id="CLU_051314_6_1_11"/>
    <dbReference type="OMA" id="GTTLYWW"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACL29603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="208" mass="23146" checksum="B9F5CF8D878E1ECC" modified="2009-03-03" version="1">MDLKEKFSRKKYSPEPRDVVFTIPNIISLLRIISIPIIAWLITEHSMVWALVVLALSFASDGLDGLIARKFNQVSKIGQLLDPIADRLLILCSILALGICHVVPWWMLILVALRDVTMAVLTVVLAQHNYGPLPVHFVGKTGTAVLMISIVGLMVADIERQMPVFEMLHYAAISCAIWGIGLYWMAGILYMRQGIGLLQADGRQKAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUG0</accession>
    <name>B8DUG0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphotransferase enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the fructosamine kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217937.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1354"/>
    <dbReference type="EnsemblBacteria" id="ACL29639">
        <property type="protein sequence ID" value="ACL29639"/>
        <property type="gene ID" value="BLA_1354"/>
    </dbReference>
    <dbReference type="GeneID" id="66533185"/>
    <dbReference type="KEGG" id="bla:BLA_1354"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1417"/>
    <dbReference type="HOGENOM" id="CLU_036517_0_2_11"/>
    <dbReference type="OMA" id="GNVMWTP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="PTHR12149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006221">
        <property type="entry name" value="Ketosamine-3-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="264" mass="29252" checksum="EBB48A84121CC24B" modified="2009-03-03" version="1">MGAEYRKSRRNAPRGFFECEGKGLEWLGEAQAQGGPRVVKVYGWGDDYLDIERVTPAMPTGKAAFEFGAALAHMHDAGAPYFGSAPKGYDGTCYFGPLQDPVPMDTGEWRDPATYLAEGRLRPMVQMGIERGSLRDADMDLTNEVIDALPELLGRAGEDRPARVHGDLWSGNVMWTADTGETQAVLIDPAAHGGHREEDLAMLHLFGMSYLTEITDGYMSVHPLKAGWQERITIWQLYPIAGHCVFFGGGYVSEYRQMCRSLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUH0</accession>
    <name>B8DUH0_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">secG</name>
        <name evidence="11" type="ordered locus">BLA_1364</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SecG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217926.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1364"/>
    <dbReference type="EnsemblBacteria" id="ACL29649">
        <property type="protein sequence ID" value="ACL29649"/>
        <property type="gene ID" value="BLA_1364"/>
    </dbReference>
    <dbReference type="GeneID" id="66533195"/>
    <dbReference type="KEGG" id="bla:BLA_1364"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1427"/>
    <dbReference type="HOGENOM" id="CLU_094156_7_1_11"/>
    <dbReference type="OMA" id="WFACIVV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01651">
        <property type="entry name" value="SECGEXPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL29649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="82" mass="8632" checksum="5DD94FCD0F57A905" modified="2009-03-03" version="1">MTVVKLILQIVLVVLSLLLTLLILMHKGKGGGLSDMFGGGLTQNAGSSGVAEKNLNRWTVIIALIWVAIIIALGLFTKFGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUI6</accession>
    <name>B8DUI6_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="9">4.2.1.136</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ADP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nnrD</name>
        <name evidence="12" type="ordered locus">BLA_1380</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 9 10">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 9 10">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="9"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1380"/>
    <dbReference type="EnsemblBacteria" id="ACL29665">
        <property type="protein sequence ID" value="ACL29665"/>
        <property type="gene ID" value="BLA_1380"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1380"/>
    <dbReference type="HOGENOM" id="CLU_024853_4_0_11"/>
    <dbReference type="OMA" id="HNGGDAL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052857">
        <property type="term" value="F:NADPHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030677">
        <property type="entry name" value="Nnr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017184">
        <property type="entry name" value="Nnr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0520">NAD</keyword>
    <keyword evidence="9 10" id="KW-0521">NADP</keyword>
    <keyword evidence="9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="11">
        <location>
            <begin position="11"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="456"/>
            <end position="460"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACL29665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="582" mass="60765" checksum="D3D5559A8693CEF0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUK2</accession>
    <name>B8DUK2_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspartate transcarbamylase</fullName>
            <shortName evidence="5">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">pyrB</name>
        <name evidence="9" type="ordered locus">BLA_1396</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014483163.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1396"/>
    <dbReference type="EnsemblBacteria" id="ACL29681">
        <property type="protein sequence ID" value="ACL29681"/>
        <property type="gene ID" value="BLA_1396"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1396"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1460"/>
    <dbReference type="HOGENOM" id="CLU_043846_1_2_11"/>
    <dbReference type="OMA" id="FPTEREY"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="23"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="168"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL29681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="337" mass="37021" checksum="2D48D9BDC3FD0914" modified="2009-03-03" version="1">MKGEPLSSVQQHADGQSIVGTSVITLDDLTVTQIEELLHKAQYIDSHRKEVAHTCDGRVLATLFYEPSTRTRLSFETAMLRLGGKVIGFAGSQLSSATKGESISDTLKTVSNYVDVVAIRHPKEGAALVAADASSVPVINAGDGGHMHPTQTLADLATLQSRFGRVNGLTIGLCGDLTFGRTVHSLIETLCRFGNVRFVLISPKELRTPQYVLNRINATPTCSYEEVTDLSTVIGDLDALYMTRVQKERFFNEDDYLRLRDTYILDEGKLAKAKPTMAVLHPLPRVNEIATEVDVDPRAAYFEQVKNGMLMRMALESSVLGDELPGYEQYANQEVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUK3</accession>
    <name>B8DUK3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yneG</name>
        <name evidence="1" type="ordered locus">BLA_1397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217885.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29682">
        <property type="protein sequence ID" value="ACL29682"/>
        <property type="gene ID" value="BLA_1397"/>
    </dbReference>
    <dbReference type="GeneID" id="66533981"/>
    <dbReference type="KEGG" id="bla:BLA_1397"/>
    <dbReference type="HOGENOM" id="CLU_132148_0_0_11"/>
    <dbReference type="OMA" id="QHATGTC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020378">
        <property type="entry name" value="DUF4186"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13811">
        <property type="entry name" value="DUF4186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="160" mass="17959" checksum="2876572D54962C32" modified="2009-03-03" version="1">MNGHDDESTWVEHTLVRLGESQFRAKFVLSEADRSYARDKGRHVIDRHAHEMLRARVGEAQPSNDGRQTPWRGHPVFTAQHATATCCRGCIEKWHGIAKGRPLTDAEVNRLADLVMAWIDRDLTNHPARDAVAGARSAQADARRVKAAHAKAPRYVQPEL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUK6</accession>
    <name>METE_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cobalamin-independent methionine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Methionine synthase, vitamin-B12 independent isozyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">metE</name>
        <name type="ordered locus">BLA_1400</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21196"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58140"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
            <dbReference type="EC" id="2.1.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015940177.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DUK6"/>
    <dbReference type="SMR" id="B8DUK6"/>
    <dbReference type="STRING" id="442563.BLA_1400"/>
    <dbReference type="PRIDE" id="B8DUK6"/>
    <dbReference type="EnsemblBacteria" id="ACL29685">
        <property type="protein sequence ID" value="ACL29685"/>
        <property type="gene ID" value="BLA_1400"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1400"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1464"/>
    <dbReference type="HOGENOM" id="CLU_013175_0_0_11"/>
    <dbReference type="OMA" id="KVMKGML"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0486">Methionine biosynthesis</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000123778" description="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase">
        <location>
            <begin position="1"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="706"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="442"/>
            <end position="444"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="442"/>
            <end position="444"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="526"/>
            <end position="527"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="572"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="610"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="610"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="616"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="653"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="655"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="677"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="738"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00172"/>
        </source>
    </evidence>
    <sequence length="767" mass="86685" checksum="97D9FF6BD4D45AB4" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUM1</accession>
    <name>B8DUM1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217859.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1415"/>
    <dbReference type="EnsemblBacteria" id="ACL29700">
        <property type="protein sequence ID" value="ACL29700"/>
        <property type="gene ID" value="BLA_1415"/>
    </dbReference>
    <dbReference type="GeneID" id="66533244"/>
    <dbReference type="KEGG" id="bla:BLA_1415"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1479"/>
    <dbReference type="HOGENOM" id="CLU_029375_6_3_11"/>
    <dbReference type="OMA" id="YIGMGWH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FSH1" evidence="1">
        <location>
            <begin position="205"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="333" mass="37031" checksum="F32F838920A08101" modified="2009-03-03" version="1">MTKRISSAWPYMGAAAGTMLACGMILAAGETIFSVTFDSQSNRSLFRNKSRSAFAQHDPAHRAAEDTQAQLWFEQTRHAEQIRSYDGLKLHAWRFDANTAAPLPHTHAICMHGYTGGPEEMAPWAYHYANLGMRVLVPAQRAHELSEGRFVGMGWLEREDLLRWVNSIVARDPDARILLHGNSMGAATILDVCADPRLARNVVCAVVDSGFSSEYDQMLDSVSAMLHLPKWMAKPMVDCASLVNRLSLGFGFRQANAIEQLHRTTLPILFIQGDQDDIVSPHMLGRLYTACASPVKARLQVHGAGHILGLTTDRNLYWSTVDAFLRRCLHMAD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUN4</accession>
    <name>GLGC_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucose-1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ADP-glucose pyrophosphorylase</fullName>
            <shortName evidence="1">ADPGlc PPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ADP-glucose synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glgC</name>
        <name type="ordered locus">BLA_1428</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.27" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217843.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DUN4"/>
    <dbReference type="SMR" id="B8DUN4"/>
    <dbReference type="STRING" id="442563.BLA_1428"/>
    <dbReference type="EnsemblBacteria" id="ACL29713">
        <property type="protein sequence ID" value="ACL29713"/>
        <property type="gene ID" value="BLA_1428"/>
    </dbReference>
    <dbReference type="GeneID" id="66533258"/>
    <dbReference type="KEGG" id="bla:BLA_1428"/>
    <dbReference type="HOGENOM" id="CLU_029499_14_1_11"/>
    <dbReference type="OMA" id="YRMDFSQ"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00624">
        <property type="entry name" value="GlgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005836">
        <property type="entry name" value="ADP_Glu_pyroP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023049">
        <property type="entry name" value="GlgC_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02091">
        <property type="entry name" value="glgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00808">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00809">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword id="KW-0321">Glycogen metabolism</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000147220" description="Glucose-1-phosphate adenylyltransferase">
        <location>
            <begin position="1"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="182"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00624"/>
        </source>
    </evidence>
    <sequence length="415" mass="45956" checksum="E5C8263255A89B40" modified="2009-03-03" version="1">MAKKNPKILSIVLAGGEGTRLMPLTRDRAKPAVPFGGVYRLIDFPLSNLVNSGYSQVIVLTQYKSHSLDRHISQLWRFSTLLGNYVSPVPAQQRLGKHWYLGSADAVYQTINIIEDVQPDIVVIVGADHVYRMDFEQMVNQHIESGAEFTVAGIRQPIEQSSQFGVIEVDPEHPNMIKSFQEKPKETTGLPDNPNEILASMGNYVANTDALFNALSIDSKAENTKHDMGGDIAPFFAERNEAGVYDFSRNEIPGATTTDHAYWRDVGTIRQFYDAHMDLISYIPEFNLYNMEWPIYTSSGNLPPAKFVHAAGDRIGHATDSIVSPGVIVSGGEIHHSVISPNVRVHSWSQVNDSILFDNVEINRRARVNRAILDKNVVLTENSTVGLDVEHDLARGFTVTSDGITVVPKGTVVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUQ7</accession>
    <name>B8DUQ7_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative pre-16S rRNA nuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_1452</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YqgF HJR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217816.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1452"/>
    <dbReference type="EnsemblBacteria" id="ACL29736">
        <property type="protein sequence ID" value="ACL29736"/>
        <property type="gene ID" value="BLA_1452"/>
    </dbReference>
    <dbReference type="GeneID" id="66533282"/>
    <dbReference type="KEGG" id="bla:BLA_1452"/>
    <dbReference type="HOGENOM" id="CLU_098240_0_0_11"/>
    <dbReference type="OMA" id="PMGWTAQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000967">
        <property type="term" value="P:rRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16964">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00651">
        <property type="entry name" value="Nuclease_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005227">
        <property type="entry name" value="YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33317">
        <property type="entry name" value="PTHR33317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03652">
        <property type="entry name" value="RuvX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00250">
        <property type="entry name" value="RNAse_H_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="YqgFc" evidence="3">
        <location>
            <begin position="3"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="163" mass="18132" checksum="4310C18E4B412F38" modified="2009-03-03" version="1">MPGIWLGLDLGNARVGVAASNPERSFAYPEGNIRVYGDYFQVFDDVLDLIEDKAEEGTPVTAIAIGLPLQMDGSAGSSAKKAQRWAKSLRRRLESEMEDQDSHIGVMPDIIFIDERLTTVDAHRRLFDANVSSKQHRAVVDQQSAVEILQTALDRARDNTEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUR9</accession>
    <name>B8DUR9_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-amylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">amy</name>
        <name evidence="10" type="ordered locus">BLA_1466</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217797.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1466"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29748">
        <property type="protein sequence ID" value="ACL29748"/>
        <property type="gene ID" value="BLA_1466"/>
    </dbReference>
    <dbReference type="GeneID" id="66533296"/>
    <dbReference type="KEGG" id="bla:BLA_1466"/>
    <dbReference type="HOGENOM" id="CLU_024572_2_0_11"/>
    <dbReference type="OMA" id="FFHWYYP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013776">
        <property type="entry name" value="A-amylase_thermo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001021">
        <property type="entry name" value="Alph-amls_thrmst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="9">
        <location>
            <begin position="9"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001021-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001021-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL29748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="500" mass="56022" checksum="7173B532435E5BD5" modified="2009-03-03" version="1">MAIDKPNHETMLQCFEWYLPESHNLWRWLSSQAPSVAHAGFTTAWLPPAYKGQAGDSDVGYGVYDMYDLGEFDAKGSVPTKYGSRMEYLQAIRAMQGNGVRVFADIVFNHRMGADGTEPVRTHEVNVDDRTRSDSTVVERTLNTVYDFPERGGVYSTFKWNWSDFTGTDYTTDDGTTGIMRFDGKQWSDNVSHERGNFDYIMGDDVDVNEPEVARELTDWGIWYTTTTGVDGFRLDAVKSIDAGFFAPWLRTMQRYGNHPGIAVGEYWSGDASELTSYLHDCNHCMMLFDVALHFRFEQASKNPEGFDLRGLAADTLYEREPTYACTFVDNHDTQPGQALESWVQPWFKPLAYACILLRDNVLPCVFFGDYYGVPHDLIPPMRFLPHMVWIRAHLLGDQVEAQPGDTAHSLCWVVEGNHPVCVVLNTGSSEVHRQVRNAALASHTLIDVCHPDAPATTDTQGQGMMRCPPRSCAIYIDADDYGVMLEALSGTPAAGTVCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUS5</accession>
    <name>B8DUS5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217789.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1472"/>
    <dbReference type="EnsemblBacteria" id="ACL29754">
        <property type="protein sequence ID" value="ACL29754"/>
        <property type="gene ID" value="BLA_1472"/>
    </dbReference>
    <dbReference type="GeneID" id="66533302"/>
    <dbReference type="KEGG" id="bla:BLA_1472"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1540"/>
    <dbReference type="HOGENOM" id="CLU_060318_0_0_11"/>
    <dbReference type="OMA" id="SDGWPNA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="335" mass="36270" checksum="ECA64BCC9A3B3266" modified="2009-03-03" version="1">MGFKDNLQYLRGSHNMTQEQLAMLIGVSRQSVSKWESEKAYPEMDKLLMLCDMFGVSLDDLVMGDVRNGIAMSANHVEDGLPKAPMPEMEGSALPQDITGYEEHMRKFDLMIPTGVSAIIFGVSIGNLFDSDNSILGNSDANEVAMFLCIAIGTLVGLALLIPAGLAHSAFKRQHPYVEDFYTESDRAAARKVLAIALIAGIALIMAGIAVNVWADETLHVDEGWPSTALLMFVAVGVWCIVFGGMQYGRLDIADYNKESEEQHVQENGTESIYDKGNGAVCGIIMITAPIVGLTLLFCFDGGPHGMFWMSWVIGGFLCAIASIVTGLIKSTKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUS9</accession>
    <name>B8DUS9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_1476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1476"/>
    <dbReference type="EnsemblBacteria" id="ACL29758">
        <property type="protein sequence ID" value="ACL29758"/>
        <property type="gene ID" value="BLA_1476"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1476"/>
    <dbReference type="HOGENOM" id="CLU_083878_1_0_11"/>
    <dbReference type="OMA" id="QFSDELC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="280" mass="31614" checksum="153679879C440AFA" modified="2009-03-03" version="1">MDSKQRFLQIYHEFIKDDNMLPSELYIVSFRYITIYHLIFGYITLYTWTSAHPTYPSPYHDIMSTYEMRTRLIIVEGLPDSGKSTTAAMVAAELEARGRNVVCVEEGAADHPADVGDHDFPDFASERATILDTWRAFAAHAEPDTTYVFNCVLLQNPMCETMMRFGMSEDESRRYISDIAAIIAPLHPVVIYIDEPGAKSAIDGVLDERGDGWLNAVIDYHTAQGYGEAHGLRGYEGYIACLEERRERELRILRSLPVDSHIIPPSSDAKRISTVVDAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUU9</accession>
    <name>B8DUU9_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13 14">UvrABC system protein B</fullName>
            <shortName evidence="13">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 20" type="primary">uvrB</name>
        <name evidence="20" type="ordered locus">BLA_1496</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 13 14">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217749.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1496"/>
    <dbReference type="EnsemblBacteria" id="ACL29778">
        <property type="protein sequence ID" value="ACL29778"/>
        <property type="gene ID" value="BLA_1496"/>
    </dbReference>
    <dbReference type="GeneID" id="66533328"/>
    <dbReference type="KEGG" id="bla:BLA_1496"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1566"/>
    <dbReference type="HOGENOM" id="CLU_009621_2_1_11"/>
    <dbReference type="OMA" id="EYVDRMV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13 14" id="KW-0228">DNA excision</keyword>
    <keyword evidence="9 13 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 13 14" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 14" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="33"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="436"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="17">
        <location>
            <begin position="659"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="618"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="655"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin" evidence="13">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ACL29778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="703" mass="79573" checksum="F3B697BC11F37ABA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUV4</accession>
    <name>B8DUV4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP binding protein of ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">troB</name>
        <name evidence="5" type="ordered locus">BLA_1501</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217743.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1501"/>
    <dbReference type="EnsemblBacteria" id="ACL29783">
        <property type="protein sequence ID" value="ACL29783"/>
        <property type="gene ID" value="BLA_1501"/>
    </dbReference>
    <dbReference type="GeneID" id="66533333"/>
    <dbReference type="KEGG" id="bla:BLA_1501"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1571"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_11"/>
    <dbReference type="OMA" id="FDRGLPM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="12"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="303" mass="32896" checksum="1CC37F23892E483F" modified="2009-03-03" version="1">MADRMTPMQPCIVCHDIAISRGGRTIWSEGTFTIPRGSATAIVGTNGAGKTTLMKAELGLIPLSHGTMTVLGKPAGEMNAHIGYVPQSYASDIDSSLTAEQSVLLGLTGTRFGFHIISKKERDKAREAMEFVGVLDKAPYRLSQLSGGLRQRVAIAQALVSDPELLMLDEPLANLDLASQRSTVHILAKLNRELGMTIQVVAHDLNMLLPILTGAVYLLDGHPHFAKLNEVLDSKLLTHLYGTQVQVVTTPQGDMFVTPNADNIGCNDHPDMHSSSDVAQFHHHEDVRMDDDHAHIDRKGNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUV9</accession>
    <name>B8DUV9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator of two-component system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_1506</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015940194.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1506"/>
    <dbReference type="EnsemblBacteria" id="ACL29788">
        <property type="protein sequence ID" value="ACL29788"/>
        <property type="gene ID" value="BLA_1506"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1506"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1576"/>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_11"/>
    <dbReference type="OMA" id="LAEVWDW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="13"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="142"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="142"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="239" mass="26341" checksum="82ED1635539A6A8D" modified="2009-03-03" version="1">MSAPSNDNEVRRTILVVEDEPTLATAIAQRLTNEGWTARVAGDGATAVKAADKLHPDLIIMDLMLPVMDGIEATKRIEAQHPIPVLMLTARDDEADVVIGLGVGADDYMSKPFSMRELVARERALLRRVDRAKVIAHKSENDCILDFGTLVIDPAKRQVTLDGKEVHLTPTEFDLLTTLAKQPHSVLTREQLLEEVWDWVDASSTRTVDSHVKALRHKLGASTIRTVHGVGYAFEPPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUW0</accession>
    <name>B8DUW0_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BLA_1507</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217736.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1507"/>
    <dbReference type="EnsemblBacteria" id="ACL29789">
        <property type="protein sequence ID" value="ACL29789"/>
        <property type="gene ID" value="BLA_1507"/>
    </dbReference>
    <dbReference type="GeneID" id="66533339"/>
    <dbReference type="KEGG" id="bla:BLA_1507"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1577"/>
    <dbReference type="HOGENOM" id="CLU_000445_89_3_11"/>
    <dbReference type="OMA" id="RRFEVWP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="79"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="141"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL29789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="366" mass="40930" checksum="E386BA43FE76E7EC" modified="2009-03-03" version="1">MTDEAYNRRMRRSQHRRDAKRRLVRYCSTLKVEITMLIVVATVGAFLLAWVFSKTKINDWLALPVTLIVILVFTYATSRHLTDPLGQMRDAAERLSDGDYTARVPDFSNKYDEVGQLARAFNDMAEELQHEDQLRRDMIANVAHELRTPVSALQAMVENMADGVVEPNEKNMESILAQTHRLTDLISFLLDLSRIEAGSSSLNIEEFNFADFIDETIAPLKLLDSSRGHDIETHIPSNIVMEGDVDRLRQLYTNIIANALKHSLDDASVLVEAHVDDSRGTVVTNIVNFGSQIPEDVRHKIFQRFVMGITTRGSESGGTGLGLSIAKWAATLHGGSIHVVDDSRGVDFEIVLPLHPDVEGTGPRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUY1</accession>
    <name>B8DUY1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218975.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1528"/>
    <dbReference type="EnsemblBacteria" id="ACL29810">
        <property type="protein sequence ID" value="ACL29810"/>
        <property type="gene ID" value="BLA_1528"/>
    </dbReference>
    <dbReference type="GeneID" id="66533925"/>
    <dbReference type="KEGG" id="bla:BLA_1528"/>
    <dbReference type="HOGENOM" id="CLU_524469_0_0_11"/>
    <dbReference type="OMA" id="MPPPAEM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="519" mass="53162" checksum="4D6C86174AC6CC99" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUY2</accession>
    <name>DCDB_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dCTP deaminase, dUMP-forming</fullName>
            <ecNumber evidence="1">3.5.4.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Bifunctional dCTP deaminase:dUTPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">DCD-DUT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dcd</name>
        <name type="ordered locus">BLA_1529</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dCTP + 2 H2O = diphosphate + dUMP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19205"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.5.4.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dCTP deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.30" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218977.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DUY2"/>
    <dbReference type="SMR" id="B8DUY2"/>
    <dbReference type="STRING" id="442563.BLA_1529"/>
    <dbReference type="EnsemblBacteria" id="ACL29811">
        <property type="protein sequence ID" value="ACL29811"/>
        <property type="gene ID" value="BLA_1529"/>
    </dbReference>
    <dbReference type="GeneID" id="66533926"/>
    <dbReference type="KEGG" id="bla:BLA_1529"/>
    <dbReference type="HOGENOM" id="CLU_087476_2_0_11"/>
    <dbReference type="OMA" id="FENHRYP"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00667"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033973">
        <property type="term" value="F:dCTP deaminase (dUMP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008829">
        <property type="term" value="F:dCTP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006229">
        <property type="term" value="P:dUTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00146">
        <property type="entry name" value="dCTP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011962">
        <property type="entry name" value="dCTP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02274">
        <property type="entry name" value="dCTP_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000123137" description="dCTP deaminase, dUMP-forming">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="101"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="127"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for bifunctional activity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="193" mass="21687" checksum="F704B96D3E2359AA" modified="2009-03-03" version="1">MLLSDRDIRAAHAEGHISLDPWTDEMVQPASIDVRLDRFFRLFNNHAYTYVDPAENQGELTEQFEVGPDEPWILHPGEFALGSTWEYVKIDETLAARLEGKSSLGRLGILTHSTAGFIDPGFEGHITLELSNVSTLPVKLWPGMKIGQMCFFQLSSPSEHPYGSETTGSHYQGQRGPTPSRSYQNFYRAQITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUZ6</accession>
    <name>B8DUZ6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_1543</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218996.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1543"/>
    <dbReference type="EnsemblBacteria" id="ACL29825">
        <property type="protein sequence ID" value="ACL29825"/>
        <property type="gene ID" value="BLA_1543"/>
    </dbReference>
    <dbReference type="GeneID" id="66533941"/>
    <dbReference type="KEGG" id="bla:BLA_1543"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1621"/>
    <dbReference type="HOGENOM" id="CLU_377534_0_0_11"/>
    <dbReference type="OMA" id="EQASWLN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046112">
        <property type="entry name" value="DUF6049"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19516">
        <property type="entry name" value="DUF6049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870912" evidence="3">
        <location>
            <begin position="44"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="721"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="749" mass="80326" checksum="0D190637C871EDD8" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV09</accession>
    <name>B8DV09_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219021.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0004"/>
    <dbReference type="EnsemblBacteria" id="ACL28310">
        <property type="protein sequence ID" value="ACL28310"/>
        <property type="gene ID" value="BLA_0004"/>
    </dbReference>
    <dbReference type="GeneID" id="66532377"/>
    <dbReference type="KEGG" id="bla:BLA_0004"/>
    <dbReference type="HOGENOM" id="CLU_087206_2_1_11"/>
    <dbReference type="OMA" id="VWAANMK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007922">
        <property type="entry name" value="DUF721/UPF0232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05258">
        <property type="entry name" value="DciA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="167" mass="18849" checksum="E5971909F42F1239" modified="2009-03-03" version="1">MSEPPIAVTLKLDERALPAEEFEHVSARAGLIAERRVKREEALENFGKPGRDEVAFGSLFAGIAKRAGWVPHMKLAQLRHDWASIVGDVIARNTWVGAIDNGVLTIHAKSPSWTTQLTFMLPELREKVLERLNGLDIRDIRVTGPQAHGPATRRKQYVRQNMHYRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV53</accession>
    <name>B8DV53_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219327.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28354">
        <property type="protein sequence ID" value="ACL28354"/>
        <property type="gene ID" value="BLA_0051"/>
    </dbReference>
    <dbReference type="GeneID" id="66532427"/>
    <dbReference type="KEGG" id="bla:BLA_0051"/>
    <dbReference type="HOGENOM" id="CLU_193543_0_0_11"/>
    <dbReference type="OMA" id="AITSASC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870814" evidence="2">
        <location>
            <begin position="33"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="75" mass="8051" checksum="A37847B8671173C0" modified="2009-03-03" version="1">MNINSTARARLYALTAVACAIWLFQNCVEANASGDLLSWSNIILSICLIIVTGYCAVNAVLGWNTKSADTEDPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV55</accession>
    <name>B8DV55_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219332.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28356">
        <property type="protein sequence ID" value="ACL28356"/>
        <property type="gene ID" value="BLA_0053"/>
    </dbReference>
    <dbReference type="GeneID" id="66532429"/>
    <dbReference type="KEGG" id="bla:BLA_0053"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.58"/>
    <dbReference type="HOGENOM" id="CLU_143998_1_0_11"/>
    <dbReference type="OMA" id="RIAWFAP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="113" mass="12199" checksum="2EB41733F54C3A7F" modified="2009-03-03" version="1">MGAAEIVVTVVTAVACLGMGVFLGSLPFKRDELTEWHMKYQQLGGVLACGIVIVLMLLGYDLASWLAIAALAVGVAVSRIPVVRRGLLARFPELHPAERQSPLRKGTSKKRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV63</accession>
    <name>B8DV63_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BLA_0061</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0061"/>
    <dbReference type="EnsemblBacteria" id="ACL28364">
        <property type="protein sequence ID" value="ACL28364"/>
        <property type="gene ID" value="BLA_0061"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0061"/>
    <dbReference type="HOGENOM" id="CLU_027127_0_0_11"/>
    <dbReference type="OMA" id="FADWFNV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037041">
        <property type="entry name" value="Trigger_fac_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE" evidence="7">
        <location>
            <begin position="49"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE" evidence="7">
        <location>
            <begin position="229"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE_2" evidence="8">
        <location>
            <begin position="413"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="157"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL28364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="558" mass="61614" checksum="2401045B4E6D5413" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV88</accession>
    <name>B8DV88_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">rRNA (Guanine-N1-)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rrmA</name>
        <name evidence="4" type="ordered locus">BLA_0086</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218383.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0086"/>
    <dbReference type="EnsemblBacteria" id="ACL28389">
        <property type="protein sequence ID" value="ACL28389"/>
        <property type="gene ID" value="BLA_0086"/>
    </dbReference>
    <dbReference type="GeneID" id="66532461"/>
    <dbReference type="KEGG" id="bla:BLA_0086"/>
    <dbReference type="HOGENOM" id="CLU_050931_2_0_11"/>
    <dbReference type="OMA" id="MTPHGWR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016718">
        <property type="entry name" value="rRNA_m1G-MeTrfase_A_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018249">
        <property type="entry name" value="MyrA_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="3">
        <location>
            <begin position="133"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="140"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR018249-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR018249-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="317" mass="34786" checksum="8FF0EBC3C9F3D5CB" modified="2009-03-03" version="1">MSPEKLARFADSWKYFVCPLCREELRLEGTSLRCERGHTYDVARQGYVNLAPGARQSEYYSRESFEHRGQILSAGYYSHIVDAVLSAVGRYCGQIAASIDFAGLRTRSGAQLRGARGRADLRSSGPQMRAPVILDVGCGEGFYARAVQAAHPDATVLAFDISKDSVQLAAREDAGCAVRWFVGNLAELPVRDGAVDCVLDVFSPVNYAEFTRVLGGSGVVIKVVPGARHDEQLRELARGQLRHGDYSNEQVVGQFAEHFDVLERRLVSQTFPMPADDVLAFARMTPLLFNVDVDSLDLSRIHELTVEAEILVGSVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVC0</accession>
    <name>B8DVC0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative xylanase/chitin deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0118"/>
    <dbReference type="EnsemblBacteria" id="ACL28421">
        <property type="protein sequence ID" value="ACL28421"/>
        <property type="gene ID" value="BLA_0118"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0118"/>
    <dbReference type="HOGENOM" id="CLU_034359_1_0_11"/>
    <dbReference type="OMA" id="DMNVLWD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="177"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="375" mass="42099" checksum="6C685054DC51BBD9" modified="2009-03-03" version="1">MLLVLALGAGAWYMWQYHWRTLSIEVDGTAYSAKADTTVAAFMRDHRDFERKPGRLLSVEGKVLEPSGGNTVSVKFDGKQIEPADWDHTRFEKNGTLTVTPGTDLTEEHTVEQRKVPFKTDINLNGGPVQIVTQQGEDGLQEFWVGRQSKKTAAKTVIRKQEPLIVKSFAPRPEGKKVIALTFDDGPSIYSDKILDILKQNKVKATFFELGEQSLEFPKVEQRIVREGHQIASHSVSHPYFPNMSAQEQRQEIESSLSDIKKASDVSTRTFRAPYGAFGVDEWKNNATLIDRNVLWDVDTLDWKRPGEKQITKEVVDYVHNGAVVLMHSGGGDRSQTVKALPEIIKQLKKKGYSFVTIDELCKMAGLPEAAEPSR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVC2</accession>
    <name>PURA_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenylosuccinate synthetase</fullName>
            <shortName evidence="1">AMPSase</shortName>
            <shortName evidence="1">AdSS</shortName>
            <ecNumber evidence="1">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purA</name>
        <name type="ordered locus">BLA_0120</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218418.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DVC2"/>
    <dbReference type="SMR" id="B8DVC2"/>
    <dbReference type="STRING" id="442563.BLA_0120"/>
    <dbReference type="EnsemblBacteria" id="ACL28423">
        <property type="protein sequence ID" value="ACL28423"/>
        <property type="gene ID" value="BLA_0120"/>
    </dbReference>
    <dbReference type="GeneID" id="66532495"/>
    <dbReference type="KEGG" id="bla:BLA_0120"/>
    <dbReference type="HOGENOM" id="CLU_029848_0_0_11"/>
    <dbReference type="OMA" id="FHHAKPI"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000116452" description="Adenylosuccinate synthetase">
        <location>
            <begin position="1"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="38"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="40"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="298"/>
            <end position="304"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="330"/>
            <end position="332"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="412"/>
            <end position="414"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <sequence length="428" mass="46348" checksum="7C201885149B874A" modified="2009-03-03" version="1">MPGIVLIGAQWGDEGKGKATDLIGTKVDYVARFNGGNNAGHTVVVGDESYALHLLPSGIISPTATPVIGNGVVVDPEVLLEEIEGLESRGIDCSRLLVSESAHVIAPYHRMIDKVTERFAGKKKIGTTGRGIGPAYADKINRVGIRIADLFHEDVLRDKVSNALHQKNQMLVKLYNRRAFDVEATVQELLEVGVKLKPYVANTSLILNNALDDGKTVLFEGGQATMLDIDHGTYPFVTSSNPTAGGACTGTGVGPTKIDRVIGVSKAYVTRVGEGPFPTELFDENGEWLRAQGHEYGVTTGRPRRCGWFDAVVNRYATQVNGLTDIVLTKLDVLTGLDEIPVCVAYDVNGVRYDDMPTDQSAFAAAKPIYGMMPGWSEDISQVHAFEDLPQTCQDYVKRLEELSGCRISAIGTGPQRDHIIEVHSLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVK6</accession>
    <name>B8DVK6_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="12">ASA dehydrogenase</shortName>
            <shortName evidence="12">ASADH</shortName>
            <ecNumber evidence="7 12">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">asd</name>
        <name evidence="14" type="ordered locus">BLA_0205</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7 12"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218522.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0205"/>
    <dbReference type="EnsemblBacteria" id="ACL28507">
        <property type="protein sequence ID" value="ACL28507"/>
        <property type="gene ID" value="BLA_0205"/>
    </dbReference>
    <dbReference type="GeneID" id="66532579"/>
    <dbReference type="KEGG" id="bla:BLA_0205"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.216"/>
    <dbReference type="HOGENOM" id="CLU_049966_0_0_11"/>
    <dbReference type="OMA" id="CEEEMKM"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005986">
        <property type="entry name" value="Asp_semialdehyde_DH_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01296">
        <property type="entry name" value="asd_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="12 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="13">
        <location>
            <begin position="10"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="165"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACL28507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="356" mass="38088" checksum="33BED2B517E7B32B" modified="2009-03-03" version="1">MVQINDRGVNVAVLGATGQVGMVMRRVLDERDFPVKDLRFLASAHSAGKVLNWRGHDITVEDVATADLSGIDIAIFSAGGGTSKVWAPKFAEAGAYVIDNSSQWRMHDDVPLVVAEVNPDDLDEIPTGIVANPNCTTMAIMPVLKPLADKFGLKRLIVSSYQAVSGAGRAGVEQLMNEAKAAVDQGADKLVFGGDAIDFPEPTKVARTIAFNEVPFIGDIVDDGSQETDEEQKLRNESRKILHLPDLKASCTCVRVGVFTAHGMSVNAEFENPVSVEEAKEVLASAPAVELTDIPTAQLAAGKTPSFVGRIRVDQAVDDNKGLAFFVTNDNLRKGAALNAVELAEIVARKHFADQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVL9</accession>
    <name>B8DVL9_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Formate--tetrahydrofolate ligase</fullName>
            <ecNumber evidence="2">6.3.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fhs</name>
        <name evidence="7" type="ordered locus">BLA_0218</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.3" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219302.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0218"/>
    <dbReference type="EnsemblBacteria" id="ACL28520">
        <property type="protein sequence ID" value="ACL28520"/>
        <property type="gene ID" value="BLA_0218"/>
    </dbReference>
    <dbReference type="GeneID" id="66532592"/>
    <dbReference type="KEGG" id="bla:BLA_0218"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.231"/>
    <dbReference type="HOGENOM" id="CLU_030416_0_0_11"/>
    <dbReference type="OMA" id="WDGEDDQ"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL28520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="505" mass="54039" checksum="4E1D589ABC43054D" modified="2009-03-03" version="1">MTLIENFTKPYGLVDKIDAFGYLDSLKNNPDAPRKQGKVVLVTADTPLKASRGEGKTTTTIALIDALNERGIDAAAVLRQPSMGITAAGSKGGASGGGKASLTHPELIDWGLCGEMGSIEAAQNLLVSFAEKAIDDGLLDTVLVPRVSEVPSRSLRQITVDRGKGNVPERVVLTPTCELMQIVVLSRSMEEIADRVAHMIAGTKDGKPVTFGEFIDLWRITNILTDAVKPAKTETVNGSPVYVHGGPFANVSIGIPTLVSVEMACALHDVVIVEAGYGADAGAQKWLDIACREYGAQWPSAAVVVTRATTWRDDPALQWRYPFHVDRLEKLGIPTFPLINLWEGEDDQIPALRETAEELGFRDPIVGNLFRDGGEALAPQLDAFVEAVSDEALPERPKSFKGESLREKIEFVCGNAYGVPADRVIDKAGFAESEAEAERLCADAGIDFADLALVAVKSPATMTDNDAAPADERTVTLKKVEVHSGAGLVQVNLTTSLTTPMPKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVM2</accession>
    <name>B8DVM2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GtrA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BLA_0221</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219299.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0221"/>
    <dbReference type="EnsemblBacteria" id="ACL28523">
        <property type="protein sequence ID" value="ACL28523"/>
        <property type="gene ID" value="BLA_0221"/>
    </dbReference>
    <dbReference type="GeneID" id="66532595"/>
    <dbReference type="KEGG" id="bla:BLA_0221"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.233"/>
    <dbReference type="HOGENOM" id="CLU_083873_6_3_11"/>
    <dbReference type="OMA" id="FKHREDM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="10"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="185" mass="21629" checksum="95D6F791EBCA8C3D" modified="2009-03-03" version="1">MRKLIEQILKFGVVGAIAFIIDWGILNLLVGVFHMHNVIAGTISFFISLVFNYFASMKYVFKHRPDMARWMEMAIFLFSSLVGLFLNALIIWLSTYGMNRDAFITQHAEYLLRTNMGKLVATVIVAIWNFIIRKWLLDDTHTNAMNRLRRKGNVLSEEELEAKWEKSFSHRLGMWSIEHTPKGWE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVN1</accession>
    <name>LEUD_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-isopropylmalate dehydratase small subunit</fullName>
            <ecNumber evidence="1">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Alpha-IPM isomerase</fullName>
            <shortName evidence="1">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">leuD</name>
        <name type="ordered locus">BLA_0230</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LeuD family. LeuD type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218172.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DVN1"/>
    <dbReference type="SMR" id="B8DVN1"/>
    <dbReference type="STRING" id="442563.BLA_0230"/>
    <dbReference type="EnsemblBacteria" id="ACL28532">
        <property type="protein sequence ID" value="ACL28532"/>
        <property type="gene ID" value="BLA_0230"/>
    </dbReference>
    <dbReference type="GeneID" id="66532606"/>
    <dbReference type="KEGG" id="bla:BLA_0230"/>
    <dbReference type="HOGENOM" id="CLU_081378_0_1_11"/>
    <dbReference type="OMA" id="AFTTHTG"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword id="KW-0432">Leucine biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000149403" description="3-isopropylmalate dehydratase small subunit">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="226" mass="25854" checksum="12E7623C6FCB319A" modified="2009-03-03" version="1">MEKLTTITATGVPLRRSNVDTDQIIPAVFLKRVTRTGFDDALFYAWRRDPNFVLNQPEYRDGRILVAGPDFGIGSSREHAVWALHDYGFRVVIASRFADIFYGNTAKNGVLAAIMPQESIELIWKMLEEEPGRQMTVDLETRTVTIDDVVLPFEVNDYVRWRLMNGYDDIDLTLQHEDDIAAYERMRAEKFPFKPKTLPAITEEAETVESAREPEAVEWAGPLADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVQ4</accession>
    <name>B8DVQ4_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome maturation factor RimM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">rimM</name>
        <name evidence="6" type="ordered locus">BLA_0253</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Binds ribosomal protein S19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The PRC barrel domain binds ribosomal protein S19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RimM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619680.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0253"/>
    <dbReference type="EnsemblBacteria" id="ACL28555">
        <property type="protein sequence ID" value="ACL28555"/>
        <property type="gene ID" value="BLA_0253"/>
    </dbReference>
    <dbReference type="GeneID" id="66532628"/>
    <dbReference type="KEGG" id="bla:BLA_0253"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.268"/>
    <dbReference type="HOGENOM" id="CLU_077636_0_0_11"/>
    <dbReference type="OMA" id="DEFYHAD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00014">
        <property type="entry name" value="Ribosome_mat_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011961">
        <property type="entry name" value="16S_RimM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002676">
        <property type="entry name" value="RimM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036976">
        <property type="entry name" value="RimM_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01782">
        <property type="entry name" value="RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02273">
        <property type="entry name" value="16S_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RimM" evidence="4">
        <location>
            <begin position="18"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="PRC" evidence="5">
        <location>
            <begin position="106"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL28555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="217" mass="23730" checksum="6083CDDF553E4AC9" modified="2009-03-03" version="1">MHTNSVPDPQQPQELLRVCRIGKAQGLKGEVSVELYTDDPHARFAPGEVLYARESAADALRPYTVAAARTFKNRWYVRFEGVDDRNAAEALRNTVLYGEPQELDDDEFYPKDLLGLEVYLESEVSAANADDAPEGAEFEFTDLGKVVDVIEGAQWLLKIRMPNREAFLLPFVEALVPEVNLEEGYLTVDPPGGLVPGIGEPDIADTADSVGAAPPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVT1</accession>
    <name>B8DVT1_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6 7">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">rplS</name>
        <name evidence="8" type="ordered locus">BLA_0280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6 7">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268407.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0280"/>
    <dbReference type="EnsemblBacteria" id="ACL28582">
        <property type="protein sequence ID" value="ACL28582"/>
        <property type="gene ID" value="BLA_0280"/>
    </dbReference>
    <dbReference type="GeneID" id="66532657"/>
    <dbReference type="KEGG" id="bla:BLA_0280"/>
    <dbReference type="HOGENOM" id="CLU_103507_2_2_11"/>
    <dbReference type="OMA" id="TITVYYE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018257">
        <property type="entry name" value="Ribosomal_L19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01015">
        <property type="entry name" value="RIBOSOMAL_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="121" mass="13647" checksum="EECD7B7FDC6C24D2" modified="2009-03-03" version="1">MVNAIEAFDAKHMKPADEIPAFRPGDTVDVNVKIQEGNNSRIQTFTGVVIGRQGAGVRETFIVRKISFGTGVERRFPLHSPSIDSIKVVRRGRVRRAKLYYLRNLRGKAARIVERRDNSAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-10-13" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVU1</accession>
    <name>OBG_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GTPase Obg</fullName>
            <ecNumber evidence="1">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GTP-binding protein Obg</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">obg</name>
        <name type="ordered locus">BLA_0290</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268427.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DVU1"/>
    <dbReference type="SMR" id="B8DVU1"/>
    <dbReference type="STRING" id="442563.BLA_0290"/>
    <dbReference type="EnsemblBacteria" id="ACL28592">
        <property type="protein sequence ID" value="ACL28592"/>
        <property type="gene ID" value="BLA_0290"/>
    </dbReference>
    <dbReference type="GeneID" id="66532667"/>
    <dbReference type="KEGG" id="bla:BLA_0290"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.310"/>
    <dbReference type="HOGENOM" id="CLU_011747_1_0_11"/>
    <dbReference type="OMA" id="VVFDWEP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01454">
        <property type="entry name" value="GTPase_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036346">
        <property type="entry name" value="GTP-bd_prot_GTP1/OBG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015349">
        <property type="entry name" value="OCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="PTHR11702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09269">
        <property type="entry name" value="DUF1967"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102741">
        <property type="entry name" value="SSF102741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="SSF82051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03595">
        <property type="entry name" value="Obg_CgtA_exten"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51881">
        <property type="entry name" value="OCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000385743" description="GTPase Obg">
        <location>
            <begin position="1"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Obg" evidence="3">
        <location>
            <begin position="2"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="1">
        <location>
            <begin position="169"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="OCT" evidence="2">
        <location>
            <begin position="382"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="521"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="533"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="175"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="200"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="221"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="301"/>
            <end position="304"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="330"/>
            <end position="332"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="570" mass="61793" checksum="DB16528E86B4F56C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVY1</accession>
    <name>B8DVY1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphate ABC transporter, ATP-binding protein</fullName>
            <ecNumber evidence="6">3.6.3.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pstB</name>
        <name evidence="6" type="ordered locus">BLA_0330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.27" evidence="6"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268508.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0330"/>
    <dbReference type="EnsemblBacteria" id="ACL28632">
        <property type="protein sequence ID" value="ACL28632"/>
        <property type="gene ID" value="BLA_0330"/>
    </dbReference>
    <dbReference type="GeneID" id="66532709"/>
    <dbReference type="KEGG" id="bla:BLA_0330"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.354"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OMA" id="TIDICRV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015850">
        <property type="entry name" value="ABC_transpr_PstB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423:SF3">
        <property type="entry name" value="PTHR43423:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL28632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="259" mass="28647" checksum="ACA3494EE505AAB7" modified="2009-03-03" version="1">MGQQIDIRHLNIYYGSFLAVEDVNLHIAANKVTAFIGPSGCGKSTVLRTLDRMHEITPGAHVKGDVLLEGKNLYAKDVDPVAVRRDVGMVFQRPNPFPTMSIRENVLAGVSLNNRKISKSDADDLVEWALRGANLWNEVKDRLDNPGIGLSGGQQQRLCIARAVAVHPQVLLMDEPCSALDPISTLAVEDLIEELKQDYTIVIVTHNMQQAARIADYTAFFNLKAVGQPGHLEYFADTSTMFNNPQNEEAERYVSGRFG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW19</accession>
    <name>RS3_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsC</name>
        <name type="ordered locus">BLA_0368</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268583.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DW19"/>
    <dbReference type="SMR" id="B8DW19"/>
    <dbReference type="STRING" id="442563.BLA_0368"/>
    <dbReference type="EnsemblBacteria" id="ACL28670">
        <property type="protein sequence ID" value="ACL28670"/>
        <property type="gene ID" value="BLA_0368"/>
    </dbReference>
    <dbReference type="GeneID" id="66532751"/>
    <dbReference type="KEGG" id="bla:BLA_0368"/>
    <dbReference type="HOGENOM" id="CLU_058591_0_2_11"/>
    <dbReference type="OMA" id="KTNPIGN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000165477" description="30S ribosomal protein S3">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="1">
        <location>
            <begin position="43"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="277" mass="31569" checksum="E2929FA2692F2D2F" modified="2009-03-03" version="1">MGQKINPFGYRLGITESHRSKWFSDSNKVGERYRDFVLEDDAIRKVMNKDLERAGVSRIIIERTRDRVRVDIHTARPGIVIGRRGAEAERVRAKLEKLTGKQVQLNIFEVKNPAIDAQLVAQGIAEQLTNRVTFRRAMRKAQQDAMRAGAKGIRIKLSGRLGGAEMSRSEFYREGRVPLQTLRALIDYGFFEAKTTYGRIGVKVWIYKGDMTEREFEEQQAQQGNNRPGRRGGDRRPRRGQRAGQRPTGQNQVKTGPDQQMEAEVSKEAAVEPETKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW35</accession>
    <name>B8DW35_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">infA</name>
        <name evidence="5" type="ordered locus">BLA_0384</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IF-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268611.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0384"/>
    <dbReference type="EnsemblBacteria" id="ACL28686">
        <property type="protein sequence ID" value="ACL28686"/>
        <property type="gene ID" value="BLA_0384"/>
    </dbReference>
    <dbReference type="GeneID" id="66532767"/>
    <dbReference type="KEGG" id="bla:BLA_0384"/>
    <dbReference type="HOGENOM" id="CLU_151267_1_0_11"/>
    <dbReference type="OMA" id="AHVSGKM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="72" mass="8406" checksum="801E0D33F3EA9DB5" modified="2009-03-03" version="1">MAKDGVIEVEGRVVEALPNAMFRVELENKHIVLATISGKMRKNYIRILPQDRVVLEMSPYDLNRGRITYRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW87</accession>
    <name>B8DW87_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5 8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">galE</name>
        <name evidence="10" type="ordered locus">BLA_0437</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5 8"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268726.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0437"/>
    <dbReference type="EnsemblBacteria" id="ACL28738">
        <property type="protein sequence ID" value="ACL28738"/>
        <property type="gene ID" value="BLA_0437"/>
    </dbReference>
    <dbReference type="GeneID" id="66532822"/>
    <dbReference type="KEGG" id="bla:BLA_0437"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.466"/>
    <dbReference type="HOGENOM" id="CLU_007383_1_10_11"/>
    <dbReference type="OMA" id="KVMTGQY"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="9">
        <location>
            <begin position="3"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL28738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="336" mass="37102" checksum="C0146A27383A455F" modified="2009-03-03" version="1">MTVLVTGGCGYIGAHVVHALHEAGEDVVVVDDLSYGKPNRIGNARLYGMDIATPGAGERLAEIMEAENVDSVIHFAARKQVGESVEKPLWYYQQNINGMLNVLEGMKEAGVKKLVFSSSAATYGVPPVDVVPEDVEPMVPINPYGQTKLFGEWMARACEQPYGIRFCGLRYFNVAGCGPVQLEDPAILNLIPMLFDRLKQGKAPAIFGDDYPTPDGTCVRDYIHVSDLADAHIAALKYLDRDERKYDVFNVGTGEGTSVRQIVDEVKKVTGLPFKETVMGRRAGDPPHLIGSPERINTEMGWHAKYDVEDIVESAWNAWQANPDHHIDVETWKQTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW90</accession>
    <name>B8DW90_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">5'-nucleotidase</fullName>
            <ecNumber evidence="1">3.1.3.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.5" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268732.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0440"/>
    <dbReference type="EnsemblBacteria" id="ACL28741">
        <property type="protein sequence ID" value="ACL28741"/>
        <property type="gene ID" value="BLA_0440"/>
    </dbReference>
    <dbReference type="GeneID" id="66532826"/>
    <dbReference type="KEGG" id="bla:BLA_0440"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.471"/>
    <dbReference type="HOGENOM" id="CLU_060123_0_0_11"/>
    <dbReference type="OMA" id="IRTLMAW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010394">
        <property type="entry name" value="5-nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31367">
        <property type="entry name" value="PTHR31367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06189">
        <property type="entry name" value="5-nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="331" mass="36400" checksum="FA8E50172D2FDD9E" modified="2009-03-03" version="1">MGQTLDNKALVIGVASSALFDLGESDQIFREEGVEAYERYQNEHLDEPFRPGVAFPFISKLLEFNSVFDGDDQGVEVVVLSRNSPRTGLRVMNSIEHYGLDITRSVFRSGISPFEYMKAFDMALFLSADDADVREAVAEGFPAGCVLPLSDSGNRGDGTAAEATHVHESGEELRVAFDFDGVLAGDSAERVFREAQVSDPANALEKYNEHEADLANRPIEEGPLKRLLEGINILQNAAREYREANPAAQTPNLRVALVTARSGKAQKRAVNTLEDWGLTVDDAFFLGGLNKAPFLNRMQPDIFFDDQMGNLDRYTLSIPSVHIPFGAHNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW91</accession>
    <name>B8DW91_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268736.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28742">
        <property type="protein sequence ID" value="ACL28742"/>
        <property type="gene ID" value="BLA_0441"/>
    </dbReference>
    <dbReference type="GeneID" id="66532827"/>
    <dbReference type="KEGG" id="bla:BLA_0441"/>
    <dbReference type="HOGENOM" id="CLU_110255_0_0_11"/>
    <dbReference type="OMA" id="KQIHHEP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="191" mass="22165" checksum="58953CB05AA1595E" modified="2009-03-03" version="1">MQPNKTLSVNGEPFEVLRLLGKGKGGYSFLVRSQSHSKTEYVLKQMHHEPMPFLQPNDKVQAEIRDYRRLCELGIRLPAMLDIDIAKERILKEYIDGPTVYNLVLTDQMDDSYVDQVREMAKRLQSHRLNIDYFPTNFVVENGLVYYIDFECTAYTRERSFDGWGVTYWSKTPEFLRFVAAHAPHAPAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWB1</accession>
    <name>B8DWB1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable permease of ABC transporter system for sugars</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BLA_0463</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268783.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0463"/>
    <dbReference type="EnsemblBacteria" id="ACL28762">
        <property type="protein sequence ID" value="ACL28762"/>
        <property type="gene ID" value="BLA_0463"/>
    </dbReference>
    <dbReference type="GeneID" id="66532845"/>
    <dbReference type="KEGG" id="bla:BLA_0463"/>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_11"/>
    <dbReference type="OMA" id="SCIWQFT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="116"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL28762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="326" mass="36035" checksum="BA83CD42EA4CED1A" modified="2009-03-03" version="1">MTTTVSTDIQNTRNARRIERDRQRRIAQDERAERKRSRKNGFTNVANPRKSTLLTIVCAVFAIYCLFPFLYILINSTKTQADFTSTFGLGFGKTFALWDNIKTVFTYQDGIFGRWFLNTLFYVIVGAGGATLLAIMGGYALAKFRFPGRKAVFAVIIGAISVPGIALAVPQFLLFAKLGLTNTPWAMIIPSLISPFGLYLMWIFSEQAVPTELLEAARVDGASEARTFFTVALPLLSPGIVTCALFTIVATWNNYFLPLIMLKDANWYPLTIGLNQWKDQASTAGGQAIQNLVITGSMITIIPLVVAFLLLQKYWQSGLAAGAVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWC1</accession>
    <name>B8DWC1_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="1 2">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hpt</name>
        <name evidence="4" type="ordered locus">BLA_0473</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="1 2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268795.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0473"/>
    <dbReference type="EnsemblBacteria" id="ACL28772">
        <property type="protein sequence ID" value="ACL28772"/>
        <property type="gene ID" value="BLA_0473"/>
    </dbReference>
    <dbReference type="GeneID" id="66532858"/>
    <dbReference type="KEGG" id="bla:BLA_0473"/>
    <dbReference type="HOGENOM" id="CLU_073615_0_0_11"/>
    <dbReference type="OMA" id="TMDWMAV"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="3">
        <location>
            <begin position="17"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="187" mass="21014" checksum="DC72238A98701051" modified="2009-03-03" version="1">MRIVDVQNEIDHELITHDEIMKRIQEAADQVSEDYKHTLPLLVCVLKGAANTMTAFAQAMSIQVELDYMSLSSYGAGTSSSGTITVRQDLSRDVRGRDVIIVEDIIDSGRTLDWLVNELKSRGAKSVEIFALLEKPARRVIDVDVKYKGFEIPDEFVVGFGLDYDERYRNLDSIAVLKPEVYEGAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWC2</accession>
    <name>B8DWC2_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">ftsH</name>
        <name evidence="9" type="ordered locus">BLA_0474</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268796.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0474"/>
    <dbReference type="MEROPS" id="M41.015"/>
    <dbReference type="EnsemblBacteria" id="ACL28773">
        <property type="protein sequence ID" value="ACL28773"/>
        <property type="gene ID" value="BLA_0474"/>
    </dbReference>
    <dbReference type="GeneID" id="66532859"/>
    <dbReference type="KEGG" id="bla:BLA_0474"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.503"/>
    <dbReference type="HOGENOM" id="CLU_000688_16_2_11"/>
    <dbReference type="OMA" id="QYGMTER"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="250"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="667"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="481"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="258"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="556"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL28773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="698" mass="76833" checksum="64816F639820DF81" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWE3</accession>
    <name>B8DWE3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PE-PGRS family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619744.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0495"/>
    <dbReference type="EnsemblBacteria" id="ACL28794">
        <property type="protein sequence ID" value="ACL28794"/>
        <property type="gene ID" value="BLA_0495"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0495"/>
    <dbReference type="HOGENOM" id="CLU_668453_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="433" mass="47211" checksum="5EF2D7BCA16529A7" modified="2009-03-03" version="1">MPRAGAGSGSGRSSSGHDGGSRMSSGHRPSMPGSGRRAGGGGSAGFPQSSGSTGSGGFDVGDLFRAAGIGMAGGYNAGRRSTRNRYGRRSMPFPEEIFDAMGQQPNYGRQQTPGPYSAGPFGTGAPGAGQGPFSPAGGPPVAPPTMQTPFGGNNNGGKKPNGGLTGLMPLIGILAALVIFLLIFMMPSCSNNEPNRNDYNVTVPESTYNRTKLDSGLPYDSNCIDDQLGWFENRTSAAKRLKVFYDKTGIQPYILFAKYNPQLKTDDEKQAWAREWYDDHIDNEDTLLFVYFAEQDVDNDVGYMTLVNGKHVSSIMDAQATEIFWTYLDEYWYSDRSTDDAIVATFDSTADRIMTKTTTKNDVHKWVIIAVIVIGMLAIGAVITWMLIKRKREHEQYVERMVTTPLEEARDPILEKYDQADHNDQVGQEQKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWE5</accession>
    <name>B8DWE5_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="10">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 15" type="primary">ileS</name>
        <name evidence="15" type="ordered locus">BLA_0497</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="10"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218193.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0497"/>
    <dbReference type="EnsemblBacteria" id="ACL28796">
        <property type="protein sequence ID" value="ACL28796"/>
        <property type="gene ID" value="BLA_0497"/>
    </dbReference>
    <dbReference type="GeneID" id="66533629"/>
    <dbReference type="KEGG" id="bla:BLA_0497"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.526"/>
    <dbReference type="HOGENOM" id="CLU_001493_1_1_11"/>
    <dbReference type="OMA" id="KMMAPFT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="PTHR42780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="13">
        <location>
            <begin position="35"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="14">
        <location>
            <begin position="746"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="10">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="10">
        <location>
            <begin position="653"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="656"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ACL28796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="1107" mass="125145" checksum="1823E70BEB2C98E4" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWF4</accession>
    <name>B8DWF4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted NADPH-dependent reductase</fullName>
            <ecNumber evidence="2">1.6.5.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.6.5.2" evidence="2"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218203.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0506"/>
    <dbReference type="EnsemblBacteria" id="ACL28805">
        <property type="protein sequence ID" value="ACL28805"/>
        <property type="gene ID" value="BLA_0506"/>
    </dbReference>
    <dbReference type="GeneID" id="66533636"/>
    <dbReference type="KEGG" id="bla:BLA_0506"/>
    <dbReference type="HOGENOM" id="CLU_055322_4_2_11"/>
    <dbReference type="OMA" id="NDWIMNE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="7"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="188" mass="20486" checksum="7294B830CDB5D01E" modified="2009-03-03" version="1">MADKPTIAFVETSLTDGSFEADLAKEIMGIVGDRAEAITIDYEDLPLAGEDPEYPLPEAALAVRDKLGNADAVWVVVSEYKKEIPDSLRNLFDWLSLPSTKDEEGKNVLDQKPVAISGVGGFEELHPRIMVGDLLEDAGMRLFPVEVGLSVPDEAVETGDWAMTGADQEALRTQADDFLTFVSENEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWG2</accession>
    <name>B8DWG2_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="11">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">cas1</name>
        <name evidence="13" type="ordered locus">BLA_0514</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="11"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0514"/>
    <dbReference type="EnsemblBacteria" id="ACL28813">
        <property type="protein sequence ID" value="ACL28813"/>
        <property type="gene ID" value="BLA_0514"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0514"/>
    <dbReference type="HOGENOM" id="CLU_466793_0_0_11"/>
    <dbReference type="OMA" id="FAYCPRL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042211">
        <property type="entry name" value="CRISPR-assoc_Cas1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013343">
        <property type="entry name" value="CRISPR-assoc_prot_Cas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022765">
        <property type="entry name" value="Dna2/Cas4_DUF83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01930">
        <property type="entry name" value="Cas_Cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00372">
        <property type="entry name" value="cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas_Cas4" evidence="12">
        <location>
            <begin position="14"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACL28813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="535" mass="60774" checksum="BD68CF4DFE43F5BD" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWL2</accession>
    <name>B8DWL2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28863">
        <property type="protein sequence ID" value="ACL28863"/>
        <property type="gene ID" value="BLA_0566"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0566"/>
    <dbReference type="HOGENOM" id="CLU_3212968_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="44" mass="4909" checksum="182982E93E901FC9" modified="2009-03-03" version="1">MCCNCNEEAPFNYSNGFQTYARPTSGPYIATTHIPSEYGPVYVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWL4</accession>
    <name>B8DWL4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protease II</fullName>
            <ecNumber evidence="3">3.4.21.83</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ptrB</name>
        <name evidence="3" type="ordered locus">BLA_0568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.83" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0568"/>
    <dbReference type="EnsemblBacteria" id="ACL28865">
        <property type="protein sequence ID" value="ACL28865"/>
        <property type="gene ID" value="BLA_0568"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0568"/>
    <dbReference type="HOGENOM" id="CLU_011290_0_1_11"/>
    <dbReference type="OMA" id="NMGAGHG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9_N" evidence="2">
        <location>
            <begin position="32"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="591"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="821" mass="90878" checksum="20CB8EA40C480A7E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWM0</accession>
    <name>B8DWM0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">trx</name>
        <name evidence="2" type="ordered locus">BLA_0574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218306.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0574"/>
    <dbReference type="EnsemblBacteria" id="ACL28871">
        <property type="protein sequence ID" value="ACL28871"/>
        <property type="gene ID" value="BLA_0574"/>
    </dbReference>
    <dbReference type="GeneID" id="66533702"/>
    <dbReference type="KEGG" id="bla:BLA_0574"/>
    <dbReference type="HOGENOM" id="CLU_090389_10_4_11"/>
    <dbReference type="OMA" id="QRVDMIN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="131" mass="14111" checksum="0AC7C6AE24254166" modified="2009-03-03" version="1">MAVKELTSADFEQAVKGNEIALFDFFATWCGPCKAFSPIFDKVADENPDIFFGKIDIDKNQELANAANVQAVPTLMIVKKGHVIYQEAGALREADLNDLIGQAKALDVEAALAAAKAAGTDQDELIEEHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWN0</accession>
    <name>B8DWN0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cps2F</name>
        <name evidence="2" type="ordered locus">BLA_0584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218316.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0584"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28881">
        <property type="protein sequence ID" value="ACL28881"/>
        <property type="gene ID" value="BLA_0584"/>
    </dbReference>
    <dbReference type="GeneID" id="66533712"/>
    <dbReference type="KEGG" id="bla:BLA_0584"/>
    <dbReference type="HOGENOM" id="CLU_025996_2_1_11"/>
    <dbReference type="OMA" id="IKYRQHG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="321" mass="36722" checksum="64A5F1CF44DD289A" modified="2009-03-03" version="1">MQPEIEILMATYNGAEYIEQQIESIQQQSVPNWKLSISDDCSSDGTLGILQRMANHDTRINIVSQGVKYGSPQANFTFLMSQASGQYVFLADQDDIWHTNKLELFMQRMHNAEARYGKNAPILAFSDLVVVDANNHVIAPSFLRFIGRNPHRTQLNELLAQNLVTGCASAMNTALLNVIQSWDPENANRMIMHDWCYALIAATLGHVVYVDEATVNYRQHGDNAMGAHSYSALKTFMSLVIHRNSIRRQRVTHMNHMLDQATYIRDALSDLQQTRNLIILDQYCALPQMTKRQRTHTLFAYEFWPNKFMDRIVQLATIRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWN5</accession>
    <name>B8DWN5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EpsQ protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">epsQ</name>
        <name evidence="2" type="ordered locus">BLA_0589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218321.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28886">
        <property type="protein sequence ID" value="ACL28886"/>
        <property type="gene ID" value="BLA_0589"/>
    </dbReference>
    <dbReference type="GeneID" id="66533717"/>
    <dbReference type="KEGG" id="bla:BLA_0589"/>
    <dbReference type="HOGENOM" id="CLU_023845_9_1_11"/>
    <dbReference type="OMA" id="HVCAIPL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="297" mass="33941" checksum="BB77227B6E00CD6E" modified="2009-03-03" version="1">MRCAGIVTYNPDLERLRANLNNTASQVDAVFVFDNGSENVADIRSLADSEYTTLRVEADPNNRGIAFALNRLLDAAKEHGFKHMLLLDQDSVPTEGMCDELERHLTGSVALVCPFILDRNRMTEEEWQAQKMPPLERLTHAAKHGAITSGSLVDVAAALEVGGFDDNLFIDYVDFDFNERLILNGYEIVKDNTVYLLHEKGKSERTWLKVPRNTSAGVQWQPLYKLGYSPMRCYYQSRNRIVYWKKYHRHTGGEGLTEIPLLMALSLLFENHRIAKLRAYSRGIHDGMKMKIVEYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWP9</accession>
    <name>B8DWP9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beta-1,4-galactosyltransferase enhancer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cpsF</name>
        <name evidence="8" type="ordered locus">BLA_0603</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218339.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0603"/>
    <dbReference type="CAZy" id="GT1">
        <property type="family name" value="Glycosyltransferase Family 1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28900">
        <property type="protein sequence ID" value="ACL28900"/>
        <property type="gene ID" value="BLA_0603"/>
    </dbReference>
    <dbReference type="GeneID" id="66533733"/>
    <dbReference type="KEGG" id="bla:BLA_0603"/>
    <dbReference type="HOGENOM" id="CLU_064541_3_0_11"/>
    <dbReference type="OMA" id="VYDRIDT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="154" mass="18151" checksum="EA9A9C79475BA923" modified="2009-03-03" version="1">MVHKRKPRLCFVSSSGGHWEQLQKLLPLAEKYEGFFVTEKTQFETPRAKYFMKQTDLKDKFMVPKMIVNSARALVIWIKERPDFIITTGTMVAYPFYLLAVLFHKKFIFIETFGRANMPTEAGKKMEKHSDLFIVQWESQKKFYTKAIYGGCLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWS6</accession>
    <name>B8DWS6_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit b</fullName>
            <shortName evidence="13">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">atpF</name>
        <name evidence="16" type="ordered locus">BLA_0634</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="function">
        <text evidence="11 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12 13">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219173.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0634"/>
    <dbReference type="EnsemblBacteria" id="ACL28927">
        <property type="protein sequence ID" value="ACL28927"/>
        <property type="gene ID" value="BLA_0634"/>
    </dbReference>
    <dbReference type="GeneID" id="66533765"/>
    <dbReference type="KEGG" id="bla:BLA_0634"/>
    <dbReference type="HOGENOM" id="CLU_079215_5_0_11"/>
    <dbReference type="OMA" id="FAWKPIL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005864">
        <property type="entry name" value="ATP_synth_F0_bsu_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="SSF81573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01144">
        <property type="entry name" value="ATP_synt_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13 14" id="KW-0138">CF(0)</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 13 14" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="51"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ACL28927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="175" mass="19304" checksum="7580D777194053D5" modified="2009-03-03" version="1">MTIAANGVDLFLPETYDIVWSLIILIIVALFFYKFFLPKFQSVFDERTAKIEGGLAKAEQAQKDAEEAKKKYQAQLSTARVEASKIRDDARAEASHIIADARSRAETEAAQITANAERSLESQQQKAMVNLKGEVGSLATSLASKILGSELQDSAVQTQMIDQMLADMENDESKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWT6</accession>
    <name>B8DWT6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219156.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0644"/>
    <dbReference type="EnsemblBacteria" id="ACL28937">
        <property type="protein sequence ID" value="ACL28937"/>
        <property type="gene ID" value="BLA_0644"/>
    </dbReference>
    <dbReference type="GeneID" id="66533777"/>
    <dbReference type="KEGG" id="bla:BLA_0644"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.672"/>
    <dbReference type="HOGENOM" id="CLU_749475_0_0_11"/>
    <dbReference type="OMA" id="YQREFIY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="DUF262"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="DUF262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="314"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="372" mass="43549" checksum="983DD48E72930BC0" modified="2009-03-03" version="1">MQITENRIKVRDVYENYENDDEEGVVGYDDRLDIRPRYQREFVYKDAKRDAVIDTVLQGLPLNVMYWAKTGDDTYEVLDGQQRTISLMEYVDGNFSIKYENNAMNFDNLPEDVQERILDYELLVYICDGTDSEKLKWFKTINIAGERLTNQELRNAVYAGPWVSDAKRYFSKTNCPAARYGNSKGCNGYVKGESIRQEILETAIEWIADRDGTTVDGYMSAHQNDPTAQELWSYFRTVIEWTESLFPVYRREMKGLPWGLWYNQYHEQKYDPKALEDRVSELMADDDVTRKSGVYEYLLTGHERVLNIRAFTDRDRRAAYEKQKGICPLCQQHFELSEMQADHNIPWSKGGKTILENCVMLCVKDNIKKSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSJ4</accession>
    <name>B8DSJ4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FctX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fctX</name>
        <name evidence="5" type="ordered locus">BLA_0680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0680"/>
    <dbReference type="EnsemblBacteria" id="ACL28973">
        <property type="protein sequence ID" value="ACL28973"/>
        <property type="gene ID" value="BLA_0680"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0680"/>
    <dbReference type="HOGENOM" id="CLU_019392_0_0_11"/>
    <dbReference type="OMA" id="WNILNVG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022464">
        <property type="entry name" value="Strep_pil_isopept_link"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038174">
        <property type="entry name" value="Strep_pil_link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12892">
        <property type="entry name" value="FctA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870462" evidence="3">
        <location>
            <begin position="51"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="850"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="189"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="879" mass="94623" checksum="CFB6154688D69F3C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSK4</accession>
    <name>B8DSK4_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpsR</name>
        <name evidence="6" type="ordered locus">BLA_0690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219092.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0690"/>
    <dbReference type="EnsemblBacteria" id="ACL28983">
        <property type="protein sequence ID" value="ACL28983"/>
        <property type="gene ID" value="BLA_0690"/>
    </dbReference>
    <dbReference type="GeneID" id="66533823"/>
    <dbReference type="KEGG" id="bla:BLA_0690"/>
    <dbReference type="HOGENOM" id="CLU_148710_1_0_11"/>
    <dbReference type="OMA" id="QKKYCRF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018275">
        <property type="entry name" value="Ribosomal_S18_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00057">
        <property type="entry name" value="RIBOSOMAL_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL28983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="82" mass="9401" checksum="EEFD0B4113F152E2" modified="2009-03-03" version="1">MSRKRPQPPVKPFKKKPNPLKAAKITEIDYKDVALLRKFISDRGKIRSRRITGVTVQEQRKIATAIKNAREMALLPYATNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSL5</accession>
    <name>B8DSL5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable efflux-type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0701"/>
    <dbReference type="EnsemblBacteria" id="ACL28994">
        <property type="protein sequence ID" value="ACL28994"/>
        <property type="gene ID" value="BLA_0701"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0701"/>
    <dbReference type="HOGENOM" id="CLU_1425480_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="190" mass="20510" checksum="FEC7E990C3F376BF" modified="2009-03-03" version="1">MPAHALSLGQFPTVISRNLNLSIIATGIMAFVGILTETMTNVLLPVLMGLFTVSTATVQWLTTGYLLMVAVVISVSSYCNRRFTNRATFIIAMVLCIAALAAIAPTLHADSNAVFNTLQQLGGVVGTTVMALCLSIVQFGHGEVGSRDYMEATKQGGEWALIVVSVFVFVAILANLRAFLNERRQNVRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSL9</accession>
    <name>B8DSL9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative phosphoglycerate mutase family protein</fullName>
            <ecNumber evidence="1">5.4.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.2.-" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219365.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0705"/>
    <dbReference type="EnsemblBacteria" id="ACL28998">
        <property type="protein sequence ID" value="ACL28998"/>
        <property type="gene ID" value="BLA_0705"/>
    </dbReference>
    <dbReference type="GeneID" id="66533895"/>
    <dbReference type="KEGG" id="bla:BLA_0705"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.736"/>
    <dbReference type="HOGENOM" id="CLU_033323_13_1_11"/>
    <dbReference type="OMA" id="WLIWRDG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="222" mass="24413" checksum="B99687A3DCD5FA95" modified="2009-03-03" version="1">MESAGKLVLLRHGQTVWSQSGQYTGRTNIPLTPVGREQAAAAGERLRATFPNGFTPSNIYTSDLARAMETAELAGFAEHNVTADLEEWDYGRAEGRTREQLNAAAGYEWNVWRDGPHSLDETLSGTRVEVFEDGSEITVVNGEGEALEDAAARTRTVIEQVLPALLAGENVLLVAHAHILRILTSQWLDLAPDFGRKLHLDTAHYSVLGIYKGDHVIYSWNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSN5</accession>
    <name>B8DSN5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable permease protein of ABC-transporter for peptides</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dppC</name>
        <name evidence="7" type="ordered locus">BLA_0721</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218722.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0721"/>
    <dbReference type="EnsemblBacteria" id="ACL29014">
        <property type="protein sequence ID" value="ACL29014"/>
        <property type="gene ID" value="BLA_0721"/>
    </dbReference>
    <dbReference type="GeneID" id="66533482"/>
    <dbReference type="KEGG" id="bla:BLA_0721"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.752"/>
    <dbReference type="HOGENOM" id="CLU_028518_1_4_11"/>
    <dbReference type="OMA" id="PSPPTWM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="113"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="318" mass="34039" checksum="B824C80EB04E4CD5" modified="2009-03-03" version="1">MTDITNKPLPGQERFVAPLDETPLLSVDNVDESAPATSMWADAWRTLRKNPMFIISGIVILFILFVAIFPGVFTRTNPNYCNLENSLDGSQPGHPFGFDLQGCDVYARVVYGARTSISVGVLTTIIVVAVGTLIGAIAGFFGGWVDAVLSRLVDIFLAIPMLLGAIVVLQMFRTSSSIWKVVLVLALFGWVSTARIARGAVLSSKNLEFNTASTALGSTPMRNLFRHILPNSVAPIIVIGTTSLGSYIVSEATLSFLGIGLPPSVVSWGGDISKAQTVLRTDPMVLFYPSLALAITVLAFIMMGDAVKDALDPKSRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSV6</accession>
    <name>B8DSV6_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">hflX</name>
        <name evidence="10" type="ordered locus">BLA_0793</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619834.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0793"/>
    <dbReference type="EnsemblBacteria" id="ACL29085">
        <property type="protein sequence ID" value="ACL29085"/>
        <property type="gene ID" value="BLA_0793"/>
    </dbReference>
    <dbReference type="GeneID" id="66533555"/>
    <dbReference type="KEGG" id="bla:BLA_0793"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.826"/>
    <dbReference type="HOGENOM" id="CLU_019597_7_0_11"/>
    <dbReference type="OMA" id="AEMKTGR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006809">
        <property type="entry name" value="GTP-binding_hflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="9">
        <location>
            <begin position="274"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="280"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="305"/>
            <end position="309"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="327"/>
            <end position="330"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="394"/>
            <end position="397"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL29085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="506" mass="55591" checksum="AC4367CA2D20EED4" modified="2009-03-03" version="1">MGNPRYTEDSQTTDSQNVLDGQSQVLLDDDHAGWRGEDETWREREGRNELKHVAGLGELEDVTEVEYRKVRLEKVVLVGVWSSRESTFAQAEESLRELAALAETAGAEVCDGVLQQRSRPDGTSYVGSGKAREIADIVAANDADTIIVDADLPPSQRRALEDLTHVKVVDRTAVILDIFAQHATSREGKAQVELAQLQYMLPRLRGWGAALSRQAGGRAAGADAGIGSRGPGETKIEMDRRVIRTRIARLRKQIKEMSGTREVKRGSRRRYGLPTIAVVGYTNAGKSSLTNRLTGSTELVENALFATLDTAVRRTQTRDGRLYAYVDTVGFVRRLPTNLVEAFKSTLEEIADADLIVHVVDASHPDPFSQIDAVNEVLQTIDGVERLPVITVFNKADLIDDAKRERLHALAPDAHIVSSATGEGVDALRADVESMLVDPDVHVEALLPYTEGSLLAKVREYGRLESLEYRDDGIMLQAFVDERLAARIMDVALHETDAPEHGEGGE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSX3</accession>
    <name>SEPF_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell division protein SepF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">sepF</name>
        <name type="ordered locus">BLA_0810</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Localizes to the division site, in a FtsZ-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SepF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218599.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DSX3"/>
    <dbReference type="SMR" id="B8DSX3"/>
    <dbReference type="STRING" id="442563.BLA_0810"/>
    <dbReference type="EnsemblBacteria" id="ACL29102">
        <property type="protein sequence ID" value="ACL29102"/>
        <property type="gene ID" value="BLA_0810"/>
    </dbReference>
    <dbReference type="GeneID" id="66533572"/>
    <dbReference type="KEGG" id="bla:BLA_0810"/>
    <dbReference type="HOGENOM" id="CLU_078499_0_2_11"/>
    <dbReference type="OMA" id="RQITTIH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01197">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023052">
        <property type="entry name" value="Cell_div_SepF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007561">
        <property type="entry name" value="Cell_div_SepF/SepF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038594">
        <property type="entry name" value="SepF-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35798">
        <property type="entry name" value="PTHR35798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04472">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0717">Septation</keyword>
    <feature type="chain" id="PRO_1000164528" description="Cell division protein SepF">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="156" mass="17130" checksum="87D90BEAA5EAD759" modified="2009-03-03" version="1">MAGFMKRTMSYLGMSDVVPEDEDDEVIDEEPESSFDTDRSVTPIPAASTQPSTSQRKSVAPFHANINRITTIHPQSYEDAQLVGRALRDGIPVVLNLTDVSQSQAYRIIDFSSGVVFGISGSIERVTERVFLLSPARVDIVAEDTESGMSDNLFEN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSX7</accession>
    <name>THIM_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydroxyethylthiazole kinase</fullName>
            <ecNumber evidence="1">2.7.1.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">4-methyl-5-beta-hydroxyethylthiazole kinase</fullName>
            <shortName evidence="1">TH kinase</shortName>
            <shortName evidence="1">Thz kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiM</name>
        <name type="ordered locus">BLA_0814</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Thz kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.50" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619839.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DSX7"/>
    <dbReference type="SMR" id="B8DSX7"/>
    <dbReference type="STRING" id="442563.BLA_0814"/>
    <dbReference type="EnsemblBacteria" id="ACL29106">
        <property type="protein sequence ID" value="ACL29106"/>
        <property type="gene ID" value="BLA_0814"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0814"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.848"/>
    <dbReference type="HOGENOM" id="CLU_019943_0_1_11"/>
    <dbReference type="OMA" id="KRPLVHN"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004417">
        <property type="term" value="F:hydroxyethylthiazole kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01170">
        <property type="entry name" value="THZ_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00228">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000417">
        <property type="entry name" value="Hyethyz_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02110">
        <property type="entry name" value="HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000513">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01099">
        <property type="entry name" value="HYETHTZKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000383822" description="Hydroxyethylthiazole kinase">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="303" mass="31354" checksum="3C89F1F5D4BA0A97" modified="2009-03-03" version="1">MTTASTTPNSDTSNLHEVAPDDPIRERIRQAAQNVREQTPLAQSFTNFVTINLVANAQLAAGGTAAMSFLPNDVTSLASSCGATYINVGTLLPFYRDALQEISEHLSRHGCKWVLDPVAAGVGVARTEILKGFKDYPPTVIRANASEALVLHDMWQLGDAAGTDEHNGPAGVEAADSVDAAITAATDLAAYLALHSPTHTGAVAVSGEVDLVTDGRLVYRLPGGSAMMTKITGAGCSLGGVTATYLAVADALVASLAASMLYNVSSGAAERASHGPGSFQTAFLDALWNVTPEEIASAPLYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSZ1</accession>
    <name>B8DSZ1_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">1-deoxy-D-xylulose 5-phosphate reductoisomerase</fullName>
            <shortName evidence="7">DXP reductoisomerase</shortName>
            <ecNumber evidence="7">1.1.1.267</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">1-deoxyxylulose-5-phosphate reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">dxr</name>
        <name evidence="11" type="ordered locus">BLA_0828</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.267"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXR family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="7"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218577.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0828"/>
    <dbReference type="EnsemblBacteria" id="ACL29120">
        <property type="protein sequence ID" value="ACL29120"/>
        <property type="gene ID" value="BLA_0828"/>
    </dbReference>
    <dbReference type="GeneID" id="66533589"/>
    <dbReference type="KEGG" id="bla:BLA_0828"/>
    <dbReference type="HOGENOM" id="CLU_035714_1_0_11"/>
    <dbReference type="OMA" id="PIDSEHF"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00183">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013644">
        <property type="entry name" value="DXP_reductoisomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026877">
        <property type="entry name" value="DXPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036169">
        <property type="entry name" value="DXPR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="PTHR30525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08436">
        <property type="entry name" value="DXP_redisom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13288">
        <property type="entry name" value="DXPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006205">
        <property type="entry name" value="Dxp_reductismrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69055">
        <property type="entry name" value="SSF69055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00243">
        <property type="entry name" value="Dxr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DXP_reductoisom" evidence="8">
        <location>
            <begin position="8"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="DXP_redisom_C" evidence="9">
        <location>
            <begin position="150"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="DXPR_C" evidence="10">
        <location>
            <begin position="266"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="11"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL29120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="396" mass="42252" checksum="3FE46C5F8214F9DD" modified="2009-03-03" version="1">MEAEHQRVIILGSTGSIGTQALDVINRHRDRFEVAGLAAGGSHVELLAEQAASFHVPLVVVSNPQAEEPLRQALDAKGAHATQIRSGQDEVVALAGAGASVVLNGITGSIGLEPSIAALQADSQLALANKESVVAGGHLLFDAQTREHQINPVDSEHSAIWQSLRAGTHAEVSKLIVTASGGPFRGWTREQMESVTPQQALNHPTWNMGPVVTINSSTLMNKGLEVIEASRLFDVAADNIEVTVHPQSIVHSMVEFCDGATISQASPPDMRLPIALGLSAPVRLDDVARGCDWTKASEWTFEPLDNDAFPAVNLARQCLKASEKHTTVLNAANEQAVHAFLDGRLAYLDIVPSVAETIEQMDAQLSANPLFESVAEVEELEREARVRANEIIAAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT13</accession>
    <name>B8DT13_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_0850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NlpA lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218541.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0850"/>
    <dbReference type="EnsemblBacteria" id="ACL29142">
        <property type="protein sequence ID" value="ACL29142"/>
        <property type="gene ID" value="BLA_0850"/>
    </dbReference>
    <dbReference type="GeneID" id="66533612"/>
    <dbReference type="KEGG" id="bla:BLA_0850"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.886"/>
    <dbReference type="HOGENOM" id="CLU_067080_0_1_11"/>
    <dbReference type="OMA" id="HIEPMGV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004872">
        <property type="entry name" value="Lipoprotein_NlpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30429">
        <property type="entry name" value="PTHR30429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03180">
        <property type="entry name" value="Lipoprotein_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870472" evidence="5">
        <location>
            <begin position="45"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="298" mass="31520" checksum="A389C688D335CDC1" modified="2009-03-03" version="1">MTIATAFTTLKSKRRTLTRAFAAVLAAATLLGTAACGTAQNASAEGIAEPVDGKTTKVTIGVCAGPYGDMVEEVFAPLLKEKGYEVSTKVFNDYVQPDKALASGKIDANLMQHGNYLKKFSADNDLDLISLGQTPTLGLGIYSNKYHSIDEIADGATVAIANDGSNLARSLGVLQQNKLVTIKDGVDATKASVNDITSNPKHLNIKPIDAAQLARSLDTVDVSLVPGNYSWAAGLDPKNALALEQQDDGVIEVFAIAGQNKDTHFAKTVRDLLGSDEFRQAIAASKFKDFGKPASWAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT23</accession>
    <name>B8DT23_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0860"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29152">
        <property type="protein sequence ID" value="ACL29152"/>
        <property type="gene ID" value="BLA_0860"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0860"/>
    <dbReference type="HOGENOM" id="CLU_019973_0_0_11"/>
    <dbReference type="OMA" id="NGWWMCL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045699">
        <property type="entry name" value="GlfT2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040492">
        <property type="entry name" value="GlfT2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19320">
        <property type="entry name" value="GlfT2_domain3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17994">
        <property type="entry name" value="Glft2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glft2_N" evidence="1">
        <location>
            <begin position="58"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="GlfT2_domain3" evidence="2">
        <location>
            <begin position="465"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="645" mass="73011" checksum="EF1BFC3D16C7E0A3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT54</accession>
    <name>B8DT54_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DedA integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dedA</name>
        <name evidence="4" type="ordered locus">BLA_0891</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219284.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0891"/>
    <dbReference type="EnsemblBacteria" id="ACL29183">
        <property type="protein sequence ID" value="ACL29183"/>
        <property type="gene ID" value="BLA_0891"/>
    </dbReference>
    <dbReference type="GeneID" id="66533870"/>
    <dbReference type="KEGG" id="bla:BLA_0891"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.933"/>
    <dbReference type="HOGENOM" id="CLU_044208_6_1_11"/>
    <dbReference type="OMA" id="NYEIGRR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="249" mass="27045" checksum="0422D2878EA3F4C7" modified="2009-03-03" version="1">MGFIQFIANLLKDPRAAIAGWIAMGVAPTLGFVFLIVFIETGVVFFPFLPGDSLLFAAGFFAAPDAATGKSALPLAALLPVVWLAPILGDQCNYFIGHFFGRRIIESGKVKAMTPERLAKTEKMIDRWGPLAVFLGRFFPFIRTFMPFISGISGMRWSRFTPFSVLGGLVWSSLFTLLGYFFGGIPVVQDNFELVIVAILVISLIPTFVGLIKAKTGKKEAPAHAMAEVAEKEATPLVEDLDGNIEHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT76</accession>
    <name>B8DT76_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible solute binding protein of ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0913"/>
    <dbReference type="EnsemblBacteria" id="ACL29205">
        <property type="protein sequence ID" value="ACL29205"/>
        <property type="gene ID" value="BLA_0913"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0913"/>
    <dbReference type="HOGENOM" id="CLU_031285_12_3_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870477" evidence="1">
        <location>
            <begin position="37"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="450" mass="49363" checksum="9C30D147E9C325BD" modified="2009-03-03" version="1">MRKGSKMNRTVKATVGLVAIAAMSLTGLAACGGSSADDGKGKVYFLNFKPEAADQWVALAKKYTDKTGVQVKVQTAASGTYEQTLKSELAKSDAPTIFQVNGPVGYQNWKGYTADLKDTGIYNELNNKDIALKDGDKVVGIPYVMETYGIIYNKDLLKKYTELPGAKIKDVKEIDSFDKLKEVADDMQAKKDQLGIKGAFTSAGFDSSSDWRFKTHLANIPLSYEFKEDGVTTQPETIKGTYLPNFKNIFDLYLKDSTTAPSQLSSKTGDDANSEFALGEAAFYQNGTWAWTDLQKAGMKPDQVGMLPIYIGAKGEENQGLATASSENCLCVNAKASEADQKASKDFLNWVVTSDEGIKALSEDMGFTTPFKTFDKVKSDNPLVEEAVEDSNSGKEQVAWNFTMMPSEEWQNQLGQAMLAYAQGTGSWDDVRKAFVDNWKTEYDNAHANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT93</accession>
    <name>B8DT93_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="14">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="14">2.7.8.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pgsA</name>
        <name evidence="14" type="ordered locus">BLA_0930</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AD011</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="14"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619879.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0930"/>
    <dbReference type="EnsemblBacteria" id="ACL29222">
        <property type="protein sequence ID" value="ACL29222"/>
        <property type="gene ID" value="BLA_0930"/>
    </dbReference>
    <dbReference type="GeneID" id="66533456"/>
    <dbReference type="KEGG" id="bla:BLA_0930"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.973"/>
    <dbReference type="HOGENOM" id="CLU_051314_2_0_11"/>
    <dbReference type="OMA" id="WSMVYYL"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00560">
        <property type="entry name" value="pgsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACL29222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="217" mass="24044" checksum="DABD41901F3F3693" modified="2009-03-03" version="1">METEKSTKQSMWSQWSSPPNLVTLARIVLVVVFLGLYIGGGAWGARNIGMRWGAAIVFIIAASTDKIDGWMARKYNQVTELGKLLDPIADKLLTLGALVVAACFNEFGNMWIGWIVTGLYVVREIGITIMRFFVIDHGGKVIAASQAGKYKTFTLCLGLGLLLIPVWSFTHAVSQPAWLTVYFIVAYALIYFSLILCLYSGYEYLRGVFAKPAVTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTC0</accession>
    <name>B8DTC0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RelA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">relA</name>
        <name evidence="1" type="ordered locus">BLA_0959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0959"/>
    <dbReference type="EnsemblBacteria" id="ACL29249">
        <property type="protein sequence ID" value="ACL29249"/>
        <property type="gene ID" value="BLA_0959"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0959"/>
    <dbReference type="HOGENOM" id="CLU_1988276_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="125" mass="13772" checksum="40EFDB95C115D064" modified="2009-03-03" version="1">MHPNGGCLPRGRPPPLGCRWVESVDDLDALDHDRLERAILRIRGHTVNGGDHSAGGLIGDLAEDRMVAVSLGVQFFITTVRTPPLNRHTLLSAVRKIDGVFDVYRITGAKDSSEPRMRRMRGPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTE0</accession>
    <name>B8DTE0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable iron sulfur protein associated with succinate dehydrogenase/fumarate reductase</fullName>
            <ecNumber evidence="9">1.3.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BLA_0979</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.1" evidence="9"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217646.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0979"/>
    <dbReference type="EnsemblBacteria" id="ACL29269">
        <property type="protein sequence ID" value="ACL29269"/>
        <property type="gene ID" value="BLA_0979"/>
    </dbReference>
    <dbReference type="GeneID" id="66533408"/>
    <dbReference type="KEGG" id="bla:BLA_0979"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1022"/>
    <dbReference type="HOGENOM" id="CLU_044838_1_0_11"/>
    <dbReference type="OMA" id="DGQYFGP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="16"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL29269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="318" mass="35219" checksum="2BAF1B0F2ED04668" modified="2009-03-03" version="1">MSSPSSVIQATVTLRVHRFTPRPERERRHSSSPFGRRGGSPFADSARAGRPRGKSWVQEYELLVRPEDTLLDCLLTIKRDIDPTLAFRYSCGHGMCGSDAVAVNGTPTLLCTAQVQDWVQRLPNISYPDDEGFRRTGDVDDADNANVFEEDLAHQIDEGDHLGVIELAALPGFPVKRDLVADIDSMLEQIRRLKPYLIHHNAIKTREDGKVDVLEYLQNPQELAKYELLSNCIACGVCEGACPVYAGGEAFIGPAALINQARFINDSRDTATEERLEALDTADGVQACQSVRACSRQCPRGIDVGEEIWQLIAQVKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTE2</accession>
    <name>B8DTE2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA protecting protein DprA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dprA</name>
        <name evidence="2" type="ordered locus">BLA_0981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0981"/>
    <dbReference type="EnsemblBacteria" id="ACL29271">
        <property type="protein sequence ID" value="ACL29271"/>
        <property type="gene ID" value="BLA_0981"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0981"/>
    <dbReference type="HOGENOM" id="CLU_029601_2_0_11"/>
    <dbReference type="OMA" id="WPSQLDD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="361" mass="38765" checksum="716CC1DA7466324F" modified="2009-03-03" version="1">MSAKALLQSDDEALARMLLTHCSECANALMTSLLKGCDSEHPGVEALRALLMVACATTEQEQRRARNTLECMFILGTARWGRKARSEGVASFQLASQRWIGRLLQLPTFDPDALCALFTGQGAYTVVIPGSPYWPESLEDLDVRSDWAPPLALWVQGDATALTSCDRPVSIVGSRGVNEYGRHVARNLACQTALNGHLVVSGGAMGIDAAAHWGALEAMNQLGAKVAGRTVAIFAGGLDHCGPTTNMRLFEQICAQHGALVSECTPSTIPEPRRFLLRNRLIAALAYSVVVAQARLRSGALNTAGWANEMNRRLFAVPGEITTPAHAGCNRLIADQQASLLSSTSDIEQLCHETHAPSIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTF2</accession>
    <name>B8DTF2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase sensor of two-component system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0991</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0991"/>
    <dbReference type="EnsemblBacteria" id="ACL29281">
        <property type="protein sequence ID" value="ACL29281"/>
        <property type="gene ID" value="BLA_0991"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0991"/>
    <dbReference type="HOGENOM" id="CLU_345367_0_0_11"/>
    <dbReference type="OMA" id="METIRHE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="556"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="587"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="632"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="684"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="330"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="810"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="847" mass="92415" checksum="BF0D52EBF8346E55" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTG2</accession>
    <name>B8DTG2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619903.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1001"/>
    <dbReference type="EnsemblBacteria" id="ACL29291">
        <property type="protein sequence ID" value="ACL29291"/>
        <property type="gene ID" value="BLA_1001"/>
    </dbReference>
    <dbReference type="GeneID" id="66533386"/>
    <dbReference type="KEGG" id="bla:BLA_1001"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1044"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_1_11"/>
    <dbReference type="OMA" id="FQPGPWM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="269" mass="28958" checksum="724339B71B01C703" modified="2009-03-03" version="1">MTTLITGATGGLGRELALLFANDDHDLLLTARHADQLAELQAKLIKQFHVHVTSVVLDLSDTEAAEKLFRYAQEKGIVIDTLVNCAGFGDWADFMHEDRRKLNAMMQVNMVTLAKLMRLFGEDMVGRHGGRILNIASVAATIPGPYMAAYYASKAFVRSLSVAVAREVRGTGVTVTCICPGSISTGFEKAAAMQGHNFFTMVRPSTPKAIAQFAYRKMQLGRALGYAGAFAKGVAFATRLAPEYLNALCAGFMNGGDPSATTSSENPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTI0</accession>
    <name>B8DTI0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable permease protein of ABC transporter system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29309">
        <property type="protein sequence ID" value="ACL29309"/>
        <property type="gene ID" value="BLA_1019"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1019"/>
    <dbReference type="HOGENOM" id="CLU_000604_61_9_11"/>
    <dbReference type="OMA" id="ALHMSAN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="81" mass="8952" checksum="C3894AD382087CCF" modified="2009-03-03" version="1">MLIFDEATSSVDTRTEQAIAKAMDALMANRTSFVIAHRLSAIRDADLILYMKHGDILEHGTHEQLLAKDGAYANLCNSQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTI1</accession>
    <name>B8DTI1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Carbon starvation protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">cstA</name>
        <name evidence="12" type="ordered locus">BLA_1020</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217702.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1020"/>
    <dbReference type="EnsemblBacteria" id="ACL29310">
        <property type="protein sequence ID" value="ACL29310"/>
        <property type="gene ID" value="BLA_1020"/>
    </dbReference>
    <dbReference type="GeneID" id="66533369"/>
    <dbReference type="KEGG" id="bla:BLA_1020"/>
    <dbReference type="HOGENOM" id="CLU_010531_2_0_11"/>
    <dbReference type="OMA" id="GTISGFH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="P:cellular response to starvation"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="CstA_C"/>
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        <property type="entry name" value="CstA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CstA_5TM"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
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        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="534"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="584"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="645"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="712"/>
            <end position="735"/>
        </location>
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        <location>
            <begin position="72"/>
            <end position="444"/>
        </location>
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        <location>
            <begin position="533"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="782"/>
            <end position="805"/>
        </location>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02554"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13722"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ACL29310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="805" mass="86081" checksum="44E42663B8044CC0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTI6</accession>
    <name>B8DTI6_BIFA0</name>
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        <submittedName>
            <fullName evidence="6">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
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        <name evidence="6" type="ordered locus">BLA_1027</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1027"/>
    <dbReference type="EnsemblBacteria" id="ACL29315">
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867526" evidence="4">
        <location>
            <begin position="28"/>
            <end position="269"/>
        </location>
    </feature>
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        <location>
            <begin position="42"/>
            <end position="258"/>
        </location>
    </feature>
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        <location>
            <begin position="74"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL29315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="269" mass="29938" checksum="484329DB50CF43AB" modified="2009-03-03" version="1">MARLRCVGSTLLSNASRPAPPQPPAYAGCSNWKGSVSMAPVVNMDSASKMFDGRPVLRNVTLTIRQGEFVSLIGRSGCGKSTLLRMIAGLVPPDSGRIDVSGEYAFGFQDARLVPWLKVWDNITLGIDTRRKFRKEAALLALRHVQLPDMADVLPHTLSGGQMQRVSLARALVRQPNLLLLDEPFGALDALTRWDMQDLLLRLRNEHGFATIMVTHDIGEALRLSDRVLVLRNGTIREELRIDRTEVDTDNRPSDFAALERRLHDALHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTK8</accession>
    <name>B8DTK8_BIFA0</name>
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        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
            <ecNumber evidence="3">3.1.1.53</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.53" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29337.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1049"/>
    <dbReference type="EnsemblBacteria" id="ACL29337">
        <property type="protein sequence ID" value="ACL29337"/>
        <property type="gene ID" value="BLA_1049"/>
    </dbReference>
    <dbReference type="GeneID" id="66532878"/>
    <dbReference type="KEGG" id="bla:BLA_1049"/>
    <dbReference type="HOGENOM" id="CLU_015150_2_0_11"/>
    <dbReference type="OMA" id="NDIHPLN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106331">
        <property type="term" value="F:sialate 4-O-acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:sialate 9-O-acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005181">
        <property type="entry name" value="SASA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039329">
        <property type="entry name" value="SIAE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22901">
        <property type="entry name" value="PTHR22901"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SASA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SASA" evidence="2">
        <location>
            <begin position="378"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="641" mass="70542" checksum="A60C87C28A41FC8D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTL5</accession>
    <name>B8DTL5_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Release factor glutamine methyltransferase</fullName>
            <shortName evidence="6">RF MTase</shortName>
            <ecNumber evidence="6">2.1.1.297</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N5-glutamine methyltransferase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein-(glutamine-N5) MTase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein-glutamine N-methyltransferase PrmC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prmC</name>
        <name evidence="9" type="ordered locus">BLA_1056</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="6"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218749.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1056"/>
    <dbReference type="EnsemblBacteria" id="ACL29344">
        <property type="protein sequence ID" value="ACL29344"/>
        <property type="gene ID" value="BLA_1056"/>
    </dbReference>
    <dbReference type="GeneID" id="66532885"/>
    <dbReference type="KEGG" id="bla:BLA_1056"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1104"/>
    <dbReference type="HOGENOM" id="CLU_018398_4_0_11"/>
    <dbReference type="OMA" id="FDARYWE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:protein-(glutamine-N5) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036009">
        <property type="term" value="F:protein-glutamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018364">
        <property type="term" value="P:peptidyl-glutamine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02126">
        <property type="entry name" value="RF_methyltr_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="Release_fac_Glu-N5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03534">
        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PrmC_N" evidence="8">
        <location>
            <begin position="5"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="MTS" evidence="7">
        <location>
            <begin position="128"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="211"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL29344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="304" mass="33590" checksum="DB2FF0C2D4A346B5" modified="2009-03-03" version="1">MTTDQLIHRCAEYLREAGVDTPEHDVKLIMADVLGCSPSDVESAAIMRTDVRALCAKYGRDDDAELVHTFKHMVCRRHAREPLQYIVGHAPFRYLDLKVGPGVFIPRQETELIAQDAIEWVTRHGIYSPRIVDLCAGSGALGLALATEIPGAQVWGVELSPQAAVWTRRNITQISRTYPDITANYHLEIADATCPITLAHLDGTVDVVVSNPPYVPQSQVPQQPEVRDFDPSLALYGGSSDGMLIPEQIIRRAYALLRPGGLFLMEHDISQPDRTVAFARASGFSDARTGADLTYRPRYLVATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTQ7</accession>
    <name>B8DTQ7_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF559 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218811.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1098"/>
    <dbReference type="EnsemblBacteria" id="ACL29386">
        <property type="protein sequence ID" value="ACL29386"/>
        <property type="gene ID" value="BLA_1098"/>
    </dbReference>
    <dbReference type="GeneID" id="66532924"/>
    <dbReference type="KEGG" id="bla:BLA_1098"/>
    <dbReference type="HOGENOM" id="CLU_052626_2_1_11"/>
    <dbReference type="OMA" id="PACTWAM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="entry name" value="DUF559"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04480">
        <property type="entry name" value="DUF559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF559" evidence="1">
        <location>
            <begin position="216"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="306" mass="35386" checksum="0301632FB7EFDD48" modified="2009-03-03" version="1">MSFEESDSLTRLREASEEAARECRRFRAEHRFGLVYVFGMTRALRLAGVEIPRIDLSAHPRLSEQRMQLVVRNKNLEPRVRAQDANHMLAVYVWDAPMDFACLGDDLIFTSPICTWAMLARFLSLEELIVLGDSILRRNTVHRQYSQADFKNYLIALRAVKGRRAPRGIVKCERALTLMRPGTDSSRETKLRLCIVQHGLPMPMINHRIRAINGNVYYLDLAYPDAKIAIEYDGMFHSGQWLHDSDRRNAIEASGWVFIQVTKTSLSDHSHRLMLVRRIAHELEMRTGIHYFVDAQTPLAELVKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTQ9</accession>
    <name>B8DTQ9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29388">
        <property type="protein sequence ID" value="ACL29388"/>
        <property type="gene ID" value="BLA_1100"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1100"/>
    <dbReference type="HOGENOM" id="CLU_3247827_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="42" mass="4439" checksum="C7CA669ADDAF0A53" modified="2009-03-03" version="1">MRSILNMILGLDNTMSGVPVTTMNSAVTLSLMNDGADARVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTR0</accession>
    <name>B8DTR0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269063.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29389">
        <property type="protein sequence ID" value="ACL29389"/>
        <property type="gene ID" value="BLA_1101"/>
    </dbReference>
    <dbReference type="GeneID" id="66533984"/>
    <dbReference type="KEGG" id="bla:BLA_1101"/>
    <dbReference type="HOGENOM" id="CLU_198945_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012550">
        <property type="entry name" value="DUF1706"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40658">
        <property type="entry name" value="PTHR40658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08020">
        <property type="entry name" value="DUF1706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="75" mass="9177" checksum="CE9473B36DFACD5E" modified="2009-03-03" version="1">MIETFNEQISYLCWMITAFSQEELFEPGHRQWASSTPSAWPVWKWIHVNTVAPFTSFRMKIRRWKREMARRDVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTT2</accession>
    <name>B8DTT2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable metal uptake regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fur</name>
        <name evidence="3" type="ordered locus">BLA_1123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218843.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1123"/>
    <dbReference type="EnsemblBacteria" id="ACL29411">
        <property type="protein sequence ID" value="ACL29411"/>
        <property type="gene ID" value="BLA_1123"/>
    </dbReference>
    <dbReference type="GeneID" id="66532947"/>
    <dbReference type="KEGG" id="bla:BLA_1123"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1177"/>
    <dbReference type="HOGENOM" id="CLU_096072_5_0_11"/>
    <dbReference type="OMA" id="YLYGVCT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="133" mass="14652" checksum="41B1D92D3CBEBB4E" modified="2009-03-03" version="1">MGERNTRQKDVIREALQGADDFISAQQLHARLEDAGEHIALATVYRQLGTMADAKQVDTVRLNGQQLFRLCNAGGHHHHLMCVSCGRTVEIDPPSEAWLQSVAQQHDFTIESHTLEVFGLCADCRAARGDCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTV2</accession>
    <name>B8DTV2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Possible glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_1143</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218871.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1143"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29431">
        <property type="protein sequence ID" value="ACL29431"/>
        <property type="gene ID" value="BLA_1143"/>
    </dbReference>
    <dbReference type="GeneID" id="66532967"/>
    <dbReference type="KEGG" id="bla:BLA_1143"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1199"/>
    <dbReference type="HOGENOM" id="CLU_059700_0_0_11"/>
    <dbReference type="OMA" id="GFHFAKP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="36"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="207"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="400" mass="44589" checksum="5FFC0F2E580A170D" modified="2009-03-03" version="1">MEAHNEAASPQSASDNATDRPLTIALVVDTFGNRGNGTSNSALQWAQELERQGHKVRLVGINAPEYPARENHIPLVSWISAKQQMHFAQPSATLFDRAFDGVDVVHIYTPFKFGRHAMAAARAKGLPVTAGFHVQPENVMYSAGPARWIPGMDRFIYWLFRRWLYSRVDAIHVPTNLGKQLLLDHGYAKPIFVISNGYAPRFIPKEQRKGDAAPQIPVRIIASGRLSNEKNHVELIEAICRCAHADDIHLTIAGTGPIRNKLVRFAKRKLKRPASIGFHKNSTMPQLLRSADLLVHPSIADLESVSVIEGMASGLVPVIADSKLSAAGQFSLCPQSSYPVGDVDALAERIDWWIDHPRELNTWGDTYARHTKDTYSVEESVRRFVEMERQIISDHTVSSR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTV4</accession>
    <name>RS12_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpsL</name>
        <name type="ordered locus">BLA_1145</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">With S4 and S5 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619944.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DTV4"/>
    <dbReference type="SMR" id="B8DTV4"/>
    <dbReference type="STRING" id="442563.BLA_1145"/>
    <dbReference type="EnsemblBacteria" id="ACL29433">
        <property type="protein sequence ID" value="ACL29433"/>
        <property type="gene ID" value="BLA_1145"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1145"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1202"/>
    <dbReference type="HOGENOM" id="CLU_104295_1_2_11"/>
    <dbReference type="OMA" id="SPALEKC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_B">
        <property type="entry name" value="Ribosomal_S12_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_S12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_1000134616" description="30S ribosomal protein S12">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-methylthioaspartic acid" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <sequence length="123" mass="13579" checksum="540507851933C745" modified="2009-03-03" version="1">MPTIEQLVRKGRRGKPKKSKTLALKGSPLRRGVCTRVYTTTPKKPNSALRKVARVRLSSGIEVTAYIPGEGHNLQEHSIVLVRGGRVKDLPGVRYHIVRGALDTQGVKDRKQGRSLYGAKKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTW4</accession>
    <name>B8DTW4_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">OMP decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pyrF</name>
        <name evidence="9" type="ordered locus">BLA_1155</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218886.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1155"/>
    <dbReference type="EnsemblBacteria" id="ACL29443">
        <property type="protein sequence ID" value="ACL29443"/>
        <property type="gene ID" value="BLA_1155"/>
    </dbReference>
    <dbReference type="GeneID" id="66532980"/>
    <dbReference type="KEGG" id="bla:BLA_1155"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1213"/>
    <dbReference type="HOGENOM" id="CLU_060704_0_0_11"/>
    <dbReference type="OMA" id="QSAFFER"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011995">
        <property type="entry name" value="OMPdecase_type-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375">
        <property type="entry name" value="PTHR43375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02127">
        <property type="entry name" value="pyrF_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="8">
        <location>
            <begin position="30"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL29443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="323" mass="34458" checksum="1F9B6C65FBAC12F2" modified="2009-03-03" version="1">MTQSLTDKEREAMHSDFGLRLSNSMKQYGPLCVGIDPHRGVLENWGYSVDAEGAELFAMRMLQAASGRAAAVKFQLSMFERYGSRGFVALERALYAARQMELITIVDCLHGGLSTTISAIADAYFKPDAPMLADAITLLPYYGARSLGGVINDALDNGRGVFIASLTSNPEGASLQTAIRQNGEYKGKTVAYGIAATAQKYNKSVKGLGSVGLIIGATISQWLQESGIEPGDFTGPILSPGYGWQGAEGSDLKNVFHGTNGNVLVTVSRAISQSGPDMDALIESTQTIAADVRKALREAIDGTSTAPRGHMANPKGLRTWEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTY1</accession>
    <name>B8DTY1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenylosuccinate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">purB</name>
        <name evidence="4" type="ordered locus">BLA_1172</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218916.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1172"/>
    <dbReference type="EnsemblBacteria" id="ACL29460">
        <property type="protein sequence ID" value="ACL29460"/>
        <property type="gene ID" value="BLA_1172"/>
    </dbReference>
    <dbReference type="GeneID" id="66532997"/>
    <dbReference type="KEGG" id="bla:BLA_1172"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1230"/>
    <dbReference type="HOGENOM" id="CLU_025566_2_0_11"/>
    <dbReference type="OMA" id="TQVNPCD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006188">
        <property type="term" value="P:IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013539">
        <property type="entry name" value="PurB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08328">
        <property type="entry name" value="ASL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="2">
        <location>
            <begin position="17"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C" evidence="3">
        <location>
            <begin position="349"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="481" mass="53500" checksum="36CA3C762EAF45CA" modified="2009-03-03" version="1">MNLSEISPAIALTPLDGRYHAQTAALVEYLSEPALNRERMRVEVEWMILLANGFAGNDWKPIVTGVKPLTEQEQAFLRSIPEEFGAQGIARHAAHEAVTHHDVKAVEYYIDDYLDSAEQVLGAPTQLTDLKTLVHFACTSEDINNLSIARCVKNAIEHVWLPGADAIVDLLAQRAEEFKDMPLLSLTHGQPATPTTLGKELAVYVYRLGRQLKHVREQEYLGKINGATGTFGAHLAALPNVDWVAVSREFVENRMGLTWNPLTTQIESHDWQAELFDTISHTNRIMHNLCVDTWMYISRGVFAQVPVKGATGSSTMPHKVNPIRFENAEANFEISCSLLDTLAATLVESRWQRDLTDSTTQRNIGSALGYSVLAHNNLLGGLKSVHPNTQVMDRELDENWEVLGEPIQTAMRAQELAGRSGMERPYEKVKELMRGHSISQADVESFIDSLDFDDETAARLKALTPATYVGLASMLVGYDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTY6</accession>
    <name>B8DTY6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">von Willebrand factor, type A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1177"/>
    <dbReference type="EnsemblBacteria" id="ACL29465">
        <property type="protein sequence ID" value="ACL29465"/>
        <property type="gene ID" value="BLA_1177"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1177"/>
    <dbReference type="HOGENOM" id="CLU_046646_1_0_11"/>
    <dbReference type="OMA" id="DAPGWWT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="98"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="352" mass="38777" checksum="FE54254756DD031B" modified="2009-03-03" version="1">MLRWQWPWALVAALLIAALVCLTIVMVSSHRRAYHDEARIYGVQDDLETEHAGALMRVWRRLNRIAVALLACALVLSCILVGRPAHVDAQDEQSSNRDIILCLDVSGSTLPYDHQVLSTYLNLLQHFKGERIGLSIFNSSSRTVFPLTDDYAMVTEQLTQANDMLKGVQTQDDIDKMSDEQYQQIADWLEGTQNRKNATSLIGDGLVGCAAMLPGFAYSKADTAQSRSREASIVLATDNVVSGSPTYSLAQALDLTSQAGINVDGLYSGPQSSEGDATTNEMRQLIERHGGLFLTQSNSASIDELVREIDGRRSHEAQAQSQTALTDVPGWWTLAVAILLAGWLVMAWRLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU09</accession>
    <name>B8DU09_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Permease protein of ABC transporter for glutamate</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gluC</name>
        <name evidence="8" type="ordered locus">BLA_1200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218144.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1200"/>
    <dbReference type="EnsemblBacteria" id="ACL29488">
        <property type="protein sequence ID" value="ACL29488"/>
        <property type="gene ID" value="BLA_1200"/>
    </dbReference>
    <dbReference type="GeneID" id="66533025"/>
    <dbReference type="KEGG" id="bla:BLA_1200"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1262"/>
    <dbReference type="HOGENOM" id="CLU_019602_1_0_11"/>
    <dbReference type="OMA" id="WQSMKLV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="17"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="225" mass="24519" checksum="CA7BF54577A607E5" modified="2009-03-03" version="1">MEGFISLFRSYNIPGAFLVNIELTLWAALFSTILGLILVMMRISPVSSLRKVSAGYVELFKNMPLTIIMVFMVLGAFAQLKLSFSDNFQTNFFWLAVTGLSLYTAAFVAESLRSGINTVPKGQAEAARAMGLNFMQSATLIIMPQAIRGSVAPLGNTLIALLKNSTVAAAASVATETSSLMSEMIEFRPDVIIQIFLIFAMGYVILILPIGILTTYLSNKLAVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU11</accession>
    <name>B8DU11_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyphosphate kinase 2 superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218141.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1202"/>
    <dbReference type="EnsemblBacteria" id="ACL29490">
        <property type="protein sequence ID" value="ACL29490"/>
        <property type="gene ID" value="BLA_1202"/>
    </dbReference>
    <dbReference type="GeneID" id="66533027"/>
    <dbReference type="KEGG" id="bla:BLA_1202"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1264"/>
    <dbReference type="HOGENOM" id="CLU_048699_1_2_11"/>
    <dbReference type="OMA" id="RTHYENV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016776">
        <property type="term" value="F:phosphotransferase activity, phosphate group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022300">
        <property type="entry name" value="PPK2-rel_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03709">
        <property type="entry name" value="PPK2_rel_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPK2" evidence="2">
        <location>
            <begin position="77"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="322" mass="36858" checksum="41AA687B346686AB" modified="2009-03-03" version="1">MASDKKNGRGSKKGESITVAERKARKVAERLAREAKSSETLSAVWSLPPAQLLRFHSHTHLVDIDAGSKPGFDGDQEAGERFIADSSSEIANYQRLMYANGIHGDTHRVLIVLQGMDASGKGGIVRHVFSQVDPMGIHYHGFGKPSEEDLAHDYLWRIRRELPSNGWISIFDRSQYEDIVMPRITGSLPEETWRARYGQINDFEAELAGSGCAIIKIFLVSSRQAQRQHFLRRLDDPTRYWKFDPSDLEARDRWDDYMAAWQEVFERTSTSIAPWYLIPADKRWYSRMVVSELLRTTMKNFNQTWPPLDADRDEALARLGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU35</accession>
    <name>B8DU35_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Glutamine synthetase</fullName>
            <ecNumber evidence="5">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glnA</name>
        <name evidence="7" type="ordered locus">BLA_1226</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="5"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218110.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1226"/>
    <dbReference type="EnsemblBacteria" id="ACL29514">
        <property type="protein sequence ID" value="ACL29514"/>
        <property type="gene ID" value="BLA_1226"/>
    </dbReference>
    <dbReference type="GeneID" id="66533050"/>
    <dbReference type="KEGG" id="bla:BLA_1226"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1288"/>
    <dbReference type="HOGENOM" id="CLU_017290_1_2_11"/>
    <dbReference type="OMA" id="PHPHEFE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="6">
        <location>
            <begin position="106"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-AMP-tyrosine" evidence="3">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR604809-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL29514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="478" mass="53116" checksum="7B8CA5A0CFCA0C28" modified="2009-03-03" version="1">MTPLKTKADAEALVNQEGIEYVSVRFTDLIGVQQHFTVPASEFLKDAFDEGMPFDGSSIEGFQAINESDMKLVPDIETAFVDPFRKHKTLDVAFSIVDPLTDEPYSRDPRQVAAKAEAYLKSTGVADTASFAPEAEFFIFDKVRFGNDMRGSFYEVDSIEAPWNSGLDVEEDGTPNIGFKNRVKRGYFPVPPADHTQDLRDDMVANLQKVGLILERAHHEVAGAGQQEINYRFNSLQHAGDDLMKYKYVIHETAALAGKAATFMPKPIAGDNGTGMHCHQSLWKDGKPLFYDEKNYGGLSDMARWYIGGLIKHSSSVLAFTNPSLNSYHRLVPGFEAPVNLVYSARNRSAAIRIPLAGTSPAAKRIEFRAPDPSCNPFLAFSAQLMAGLDGILNHIEPPEPVDKDLYELPPEEHAGIKQVPSSLAEALDALEEDHDFLTAGDVFTEDLIETWIDLKRGEIDQARLQPTPLEYELYFHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU47</accession>
    <name>B8DU47_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_1238</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218095.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1238"/>
    <dbReference type="EnsemblBacteria" id="ACL29526">
        <property type="protein sequence ID" value="ACL29526"/>
        <property type="gene ID" value="BLA_1238"/>
    </dbReference>
    <dbReference type="GeneID" id="66533060"/>
    <dbReference type="KEGG" id="bla:BLA_1238"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1301"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OMA" id="CTSIGVM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="26"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="60"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="239" mass="26294" checksum="90E1376C671FE98C" modified="2009-03-03" version="1">MTMHTETETPTTHSAMADGETSVPILQLKDVSYAYAKGGRNVLSDINYTFPSGSVTAIVGPSGAGKTTLLSLISGLTTPTGGEVLFEGHNLAKMDRYCYRSRDIGVIFQSFNLLPGLTVLENIMLTMDASGKRFDRPKRDIALDLLKQVHLPERYANERILHLSGGEQQRVAIARALSTNPQVVIADEPTGNLDPATQDDIMRIFIELAHEQNKCVIIVTHSPQIAERSDRVFQLSKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU49</accession>
    <name>B8DU49_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218091.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29528">
        <property type="protein sequence ID" value="ACL29528"/>
        <property type="gene ID" value="BLA_1240"/>
    </dbReference>
    <dbReference type="GeneID" id="66533062"/>
    <dbReference type="KEGG" id="bla:BLA_1240"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1303"/>
    <dbReference type="HOGENOM" id="CLU_2491572_0_0_11"/>
    <dbReference type="OMA" id="HRIRYGQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="86" mass="9155" checksum="ACD6247229F7DF7A" modified="2009-03-03" version="1">MFIVHNAIRNLWRNKGRSVLIIIVATIIAAASTIGFAIVQAAQRARASALENTTIGAQISLDRNKIMQSANSSGQKPDMGSFGKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU81</accession>
    <name>B8DU81_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted flavin-nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218046.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1273"/>
    <dbReference type="EnsemblBacteria" id="ACL29560">
        <property type="protein sequence ID" value="ACL29560"/>
        <property type="gene ID" value="BLA_1273"/>
    </dbReference>
    <dbReference type="GeneID" id="66533098"/>
    <dbReference type="KEGG" id="bla:BLA_1273"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1335"/>
    <dbReference type="HOGENOM" id="CLU_118461_2_0_11"/>
    <dbReference type="OMA" id="AVPVMEI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="4"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="134" mass="14880" checksum="7FC8E0E59772B8B5" modified="2009-03-03" version="1">MAQLTEDMKEFIKNNLAWVATVNQDGIPDLGPKMSMFVLDDNHLAYHERTAGQTYRNLENGSPLVVAFANFEQKKGYRFRGEVVLHTDDAIYDEQVKLANERGTKVPACVPVLEISEIEDLSAGAKAGTVISHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU84</accession>
    <name>B8DU84_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Solute binding protein of ABC transporter system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_1276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269083.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1276"/>
    <dbReference type="EnsemblBacteria" id="ACL29563">
        <property type="protein sequence ID" value="ACL29563"/>
        <property type="gene ID" value="BLA_1276"/>
    </dbReference>
    <dbReference type="GeneID" id="66533101"/>
    <dbReference type="KEGG" id="bla:BLA_1276"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1338"/>
    <dbReference type="HOGENOM" id="CLU_019602_18_4_11"/>
    <dbReference type="OMA" id="GFRSRLM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870885" evidence="2">
        <location>
            <begin position="33"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="40"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="296" mass="32015" checksum="22D3DAFAF21178F5" modified="2009-03-03" version="1">MHARLRTISRAILTISLAVGLCGCGTSVNVSAPGQAKGPVMSIGVPADEPGVGWYHDGEYSGLSVEVAKYVAKVLGYGDEQLFFHSQTPATRLDRLDDGSVDFAMVTFAYDGGKNALEMDHTQTADGTRYEVSGPYLVARNQLLVRADDARRLPDVQSLDGRTVCTVAGEYSGEQLHDRHPRIKILQRADYSECSASLLVGQSDAIAGPQPILAGLRKDGGTRYLHLQEDSYGTQAFGIAVKADQRKLMELIDTALQQMVDDGAWDAQIDAMETELGMHVDLSLNPVTVARSQDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU88</accession>
    <name>B8DU88_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase III, delta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">holA</name>
        <name evidence="1" type="ordered locus">BLA_1280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269085.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1280"/>
    <dbReference type="EnsemblBacteria" id="ACL29567">
        <property type="protein sequence ID" value="ACL29567"/>
        <property type="gene ID" value="BLA_1280"/>
    </dbReference>
    <dbReference type="GeneID" id="66533105"/>
    <dbReference type="KEGG" id="bla:BLA_1280"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1342"/>
    <dbReference type="HOGENOM" id="CLU_052338_0_0_11"/>
    <dbReference type="OMA" id="QQMRGWT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005790">
        <property type="entry name" value="DNA_polIII_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01128">
        <property type="entry name" value="holA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="320" mass="34842" checksum="70BBBBBA85234A64" modified="2009-03-03" version="1">MTAATLCLLIYGGDEYLNEQNARDAVYRLLEEHRDAELARVDARSADANSFDEAVSPSLLSQRSVVWVEHAEDADSGLLDAIVAYANETNRDPEASPVVMQCAATLKGRSVEALMRRNNIPVDTVPKLDKAKDKLNYVYQQFQSRGRRIDPQAAQQLVNVLGDHVGELAAMIRQLCFDFDDDPMRVNRVNQYLTGNPKVTGFNVADLAMGGKTARAVIALRSALAQGTEPIALIGALALQMRNLAKAAAIRQGDISKTKAAVNEWALRTANGRLGGWTSQGISACMQRLAWADEQCKSRGGDPIYALENTIELIGAKGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUA1</accession>
    <name>B8DUA1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Possible long-chain-fatty acid CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fadD</name>
        <name evidence="3" type="ordered locus">BLA_1293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218015.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1293"/>
    <dbReference type="EnsemblBacteria" id="ACL29580">
        <property type="protein sequence ID" value="ACL29580"/>
        <property type="gene ID" value="BLA_1293"/>
    </dbReference>
    <dbReference type="GeneID" id="66533119"/>
    <dbReference type="KEGG" id="bla:BLA_1293"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1355"/>
    <dbReference type="HOGENOM" id="CLU_000022_45_5_11"/>
    <dbReference type="OMA" id="PRIWTKF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="29"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="691" mass="75797" checksum="32DCF033FA5AA4CC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUA8</accession>
    <name>B8DUA8_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable dual-specificity RNA methyltransferase RlmN</fullName>
            <ecNumber evidence="12">2.1.1.192</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">23S rRNA (adenine(2503)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">23S rRNA m2A2503 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ribosomal RNA large subunit methyltransferase N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA (adenine(37)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA m2A37 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">rlmN</name>
        <name evidence="14" type="ordered locus">BLA_1300</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42916"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10282"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43332"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10485"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="12">Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the radical SAM superfamily. RlmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.192" evidence="12"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1300"/>
    <dbReference type="EnsemblBacteria" id="ACL29587">
        <property type="protein sequence ID" value="ACL29587"/>
        <property type="gene ID" value="BLA_1300"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1300"/>
    <dbReference type="HOGENOM" id="CLU_029101_0_2_11"/>
    <dbReference type="OMA" id="QVGCSLD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070040">
        <property type="term" value="F:rRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002935">
        <property type="term" value="F:tRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01849">
        <property type="entry name" value="RNA_methyltr_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027492">
        <property type="entry name" value="RNA_MTrfase_RlmN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006004">
        <property type="entry name" value="CHP00048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00275">
        <property type="entry name" value="adenosine_C2_methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00048">
        <property type="entry name" value="rRNA_mod_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="135"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="12">
        <location>
            <begin position="204"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="12">
        <location>
            <begin position="261"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="active site" description="S-methylcysteine intermediate" evidence="12">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACL29587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="393" mass="43366" checksum="67F417B90B5A512D" modified="2009-03-03" version="1">MTDDNQVSETVETGITEGGRSGAFRDVLSKNHARRGKPPVHFADLTDDERIAKAKELGLPKFRVRQLANHYYGHFDADAGYFTDFPAGKRDEVAREFFPTLIREVTRQVADDGQTIKTLWELFDGSKIESVLMRYPNRTTLCISSQVGCGMGCPFCATGQLGLTRNMSTGEILEQVRIAAAMMERGEVAGGPGRLSNVVFMGMGEPMGNYRAIVSAVRQISAMPPEGFGISARNITVSTVGVVPGIRRLAQEGMPVRLAVSLHAPNNALRDELVPMNRRFNVDEVLDAAHDYYLASKRRVSIEYALMRGINDQEIHARQLANRLNHYGDNWAHVNPIPLNPIEGSKWTASKPEDERRFLEILHNAGITATLRDTRGQDIDGACGQLAAKTNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUC5</accession>
    <name>B8DUC5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_1317</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0749 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1317"/>
    <dbReference type="EnsemblBacteria" id="ACL29604">
        <property type="protein sequence ID" value="ACL29604"/>
        <property type="gene ID" value="BLA_1317"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1317"/>
    <dbReference type="HOGENOM" id="CLU_040273_1_1_11"/>
    <dbReference type="OMA" id="RVRDRDM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010273">
        <property type="entry name" value="DUF881"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37313">
        <property type="entry name" value="PTHR37313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05949">
        <property type="entry name" value="DUF881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL29604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="280" mass="30939" checksum="FB7E5E818E472E10" modified="2009-03-03" version="1">MPPRRRGKHYDASLRLIDDLVNRPMDALYNDSRLVTKPDSKLTFWGTRIIVLIICVAVGFAGCLFVRLLNTDPRKQVRQQLASQLEAQNTHIDELEKQIADMRADVDRQSQSALPSQVEQEVRRNEAAAGATAVEGEGIVLTVADPMVTNSNAQEGSLPREKSTNRLRVVTDTDLQLLVSLMWKAGAEAISINDNRLGVQTSIRTAGNSILIGTTPVSSPYRIQAIGNKNELANRMGQKELSTLYQEFKDAGMTLQTSKENMIRLKAATPGQVSNAKEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUE0</accession>
    <name>B8DUE0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable membrane channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BLA_1334</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217966.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1334"/>
    <dbReference type="EnsemblBacteria" id="ACL29619">
        <property type="protein sequence ID" value="ACL29619"/>
        <property type="gene ID" value="BLA_1334"/>
    </dbReference>
    <dbReference type="GeneID" id="66533159"/>
    <dbReference type="KEGG" id="bla:BLA_1334"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1396"/>
    <dbReference type="HOGENOM" id="CLU_057061_0_0_11"/>
    <dbReference type="OMA" id="IFKALMY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="PTHR19139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="296"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACL29619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="340" mass="35789" checksum="A1BBB97C1175DCB5" modified="2009-03-03" version="1">MTDTTTTASVQPKKGHDLWARALSEFAGSLLICFAIYLMCTFGSAFYNVNLAFVTVCVGVIYAAMTAIFARISGAQFNPAVTVAAMLTSKTKVWDGICYIVAQILGAIVAGGLLRLVLPTSESVAANQWYAMAVNGYDKGSSLYTSLNSLGLTFSITVAIIVELLASIIVVAAAMVSMRKHGKVRSDYALVMGVAYAAASAMSFPVTGASINPARATGIAVFAQGQGLTQEPLAQLWVFWVTAILAAAIVALVIIVSQLLGTPKTSVDSDVAEAAMAQAGEVPAEDEAEAVQIAEAENYNVPLTGEQTDNDYSVIEEEDAEEETEQDDSQTDSADGVERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUG8</accession>
    <name>B8DUG8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217928.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1362"/>
    <dbReference type="EnsemblBacteria" id="ACL29647">
        <property type="protein sequence ID" value="ACL29647"/>
        <property type="gene ID" value="BLA_1362"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1362"/>
    <dbReference type="HOGENOM" id="CLU_017584_4_2_11"/>
    <dbReference type="OMA" id="WRMGWII"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="559" mass="62803" checksum="A9A8C1ED2FF79E1B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUH8</accession>
    <name>B8DUH8_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">UvrABC system protein A</fullName>
            <shortName evidence="13">UvrA protein</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">uvrA</name>
        <name evidence="16" type="ordered locus">BLA_1372</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms a heterotetramer with UvrB during the search for lesions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ABC transporter superfamily. UvrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1372"/>
    <dbReference type="EnsemblBacteria" id="ACL29657">
        <property type="protein sequence ID" value="ACL29657"/>
        <property type="gene ID" value="BLA_1372"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1372"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1436"/>
    <dbReference type="HOGENOM" id="CLU_001370_0_2_11"/>
    <dbReference type="OMA" id="PFEGIIP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00205">
        <property type="entry name" value="UvrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0742">SOS response</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="669"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="801"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="87"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <begin position="702"/>
            <end position="709"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ACL29657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="1010" mass="112134" checksum="8588FB581825B52C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUI4</accession>
    <name>B8DUI4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217910.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1378"/>
    <dbReference type="EnsemblBacteria" id="ACL29663">
        <property type="protein sequence ID" value="ACL29663"/>
        <property type="gene ID" value="BLA_1378"/>
    </dbReference>
    <dbReference type="GeneID" id="66533208"/>
    <dbReference type="KEGG" id="bla:BLA_1378"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1442"/>
    <dbReference type="HOGENOM" id="CLU_070025_0_0_11"/>
    <dbReference type="OMA" id="YQATAYC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="175"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="257" mass="28752" checksum="292A444273A99160" modified="2009-03-03" version="1">MFEELHRKMNRFWNADRTLNETDPEFIGIFSEFAYDTVVNEPGANDEKLDDHARCMAIIAAIIGAQGMDAFEMMLPISYHSGVTSVELKEIVYEATPLIGFAHTLPYLKRINDYLNVENVELPLAPQSAIDKQNRTQEGASLRRTLFGESADSDEEFRKMGAGHIDSWISGDYLGAYLTRNGLSLQEREMIAFCLLMAQPDCANELRGHIMANLRVGNTAHFLIAVASQCLPYIGYPRAMNAVKTIAEVAHSDKQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUL0</accession>
    <name>B8DUL0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Possible glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glgA</name>
        <name evidence="5" type="ordered locus">BLA_1404</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014483165.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1404"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29689">
        <property type="protein sequence ID" value="ACL29689"/>
        <property type="gene ID" value="BLA_1404"/>
    </dbReference>
    <dbReference type="GeneID" id="66533233"/>
    <dbReference type="KEGG" id="bla:BLA_1404"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1468"/>
    <dbReference type="HOGENOM" id="CLU_009583_2_3_11"/>
    <dbReference type="OMA" id="TREYPPD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009250">
        <property type="term" value="P:glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011875">
        <property type="entry name" value="M1P_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02149">
        <property type="entry name" value="glgA_Coryne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="15"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="203"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="414" mass="45786" checksum="BC4C230BEFE3783B" modified="2009-03-03" version="1">MKVDILTREYPPHVYGGAGVHVEELAKVLAERIDVTVRAFDGPRESEAAQHDGRGSLRVIGYDVPTELDGDNAAIRTFGVDLQMANDVDSELVHAHTWYTCLAGRMAQLLHDIPLVITAHSLEPFRPWKREQLGGGYNLSSWAERDAYEHADRIIAVSGGMREDILAAYPNVDPNKVVVVHNGITLADFETPAPDDAGWAVFDRYHIDRDKPTLLFVGRITRQKGLPYLLQALHFVDPDIQVVLCAGAPDTPEIGKEVKEAVARLNEERGNIIWIEEMLPKHELNALEHGCDAFICPSIYEPLGIVNLEAMACGLPVVATATGGIPEVVVDGVTGYLVPIEQKHDGTGTPTNPERFVHDLADAINEMFADPQRAKDMGERGRERARDKFSWESIADQTVAVYRSVLEERAAQHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUN2</accession>
    <name>B8DUN2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible tRNA/rRNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tnsR</name>
        <name evidence="2" type="ordered locus">BLA_1426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217846.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1426"/>
    <dbReference type="EnsemblBacteria" id="ACL29711">
        <property type="protein sequence ID" value="ACL29711"/>
        <property type="gene ID" value="BLA_1426"/>
    </dbReference>
    <dbReference type="GeneID" id="66533256"/>
    <dbReference type="KEGG" id="bla:BLA_1426"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1490"/>
    <dbReference type="HOGENOM" id="CLU_021322_3_3_11"/>
    <dbReference type="OMA" id="GYHVHRG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="1">
        <location>
            <begin position="126"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="290" mass="32091" checksum="7B3755E5F47B69F0" modified="2009-03-03" version="1">MQLVHLESIDDPQVEAYTNLTELQLRNRLEPSKGIFIAESPKVITRALAAGRQPISLLVEEPWIEGMADIFAFIDEHWGDDIPVYVASPEQLRRITGYRLHRGALAAMHRWELPTVAEVCANATRIAVLENIVDHTNVGAIMRSAAALDVDAVLVTPSCSDPLYRRAIRVSMGTVFQVPWTRIGGDDVHYWPWQGLEELHGLGFTTAAMALSDDSISLDDLVWRLHANDNTHIDKLALIFGTEGDGLSRHTIANADLTVKIPMSHDVDSLNVAASSAVAFYSTRDLKHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUQ0</accession>
    <name>B8DUQ0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_1445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217824.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29729">
        <property type="protein sequence ID" value="ACL29729"/>
        <property type="gene ID" value="BLA_1445"/>
    </dbReference>
    <dbReference type="GeneID" id="66533275"/>
    <dbReference type="KEGG" id="bla:BLA_1445"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1511"/>
    <dbReference type="HOGENOM" id="CLU_1736986_0_0_11"/>
    <dbReference type="OMA" id="GMPDGEF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL29729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="150" mass="17237" checksum="75520C1C340036B6" modified="2009-03-03" version="1">MPDGEFRELNIMAFDDKPFYRELIDDEHGTNIYDEAIDRLWQTVQLLEITITAANTHIAFIDLDSELIAFDEEDPKTLPSLCLGQIPRLTGSLSVFRRHPQAAEPADLVLFETASFTIGEEWFDMMIHGANALDVAYRHARRRLRTSRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUQ9</accession>
    <name>B8DUQ9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015940187.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1455"/>
    <dbReference type="EnsemblBacteria" id="ACL29738">
        <property type="protein sequence ID" value="ACL29738"/>
        <property type="gene ID" value="BLA_1455"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1455"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1522"/>
    <dbReference type="HOGENOM" id="CLU_132014_1_0_11"/>
    <dbReference type="OMA" id="FSYGVRR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009293">
        <property type="entry name" value="UPF0478"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06103">
        <property type="entry name" value="DUF948"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="133" mass="13834" checksum="9A446EAE52439EF4" modified="2009-03-03" version="1">MGAGEIAGLIAAIAFAILAGFLIYPLIRLGKMFDQIAETVKQTGDHALPALDEGVTTVKQVNKSLGDVNEISGAASSSMNNLGALMNLYGSFLGKPIIKLASTFYAVKVTAASFMNKGKKNQPASAEQKGKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUT8</accession>
    <name>B8DUT8_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetate kinase</fullName>
            <ecNumber evidence="6">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">ackA</name>
        <name evidence="8" type="ordered locus">BLA_1485</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the acetokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="6"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269103.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1485"/>
    <dbReference type="EnsemblBacteria" id="ACL29767">
        <property type="protein sequence ID" value="ACL29767"/>
        <property type="gene ID" value="BLA_1485"/>
    </dbReference>
    <dbReference type="GeneID" id="66533315"/>
    <dbReference type="KEGG" id="bla:BLA_1485"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1554"/>
    <dbReference type="HOGENOM" id="CLU_020352_0_1_11"/>
    <dbReference type="OMA" id="KIITCHI"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="211"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="285"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="333"/>
            <end position="337"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="410" mass="44598" checksum="BC4F85130538A53D" modified="2009-03-03" version="1">MAKTVLVINSGSSSIKYQLVDLESGEGIASGIVEKIGEPIDGHYKYEYNGEKHELDEKVENHEQGLKRVLGFFEEYGPSLEETGIIAVGHRVVQGGDTFPNPALVTPDTTAKVEELAVLAPLHNGPEAKGARVMRELLPEIPQVYVFDSSFFQQLPKASSTYALNKEVADKYKIKRYGAHGTSHWFVSSQIPEFLGIDAEAAKGLKQIVLHIGNGASASAELGGRPIETSMGLTPLEGLVMGSRTGDIDPAAVFHLMRNADMNVDELDDLFNKKSGMMGMTGFGDMREVHRLVAEGDENAKLALDIYVHRIVSYIGAYTAQLGGLDVLTFTAGVGENDEIVRRMVCEKLAPFGVKLDNDKNDTRSKEPRIISTPDSTVTVVVYPTNEELAIAQRANEIVTAGEDTYGNKI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUV2</accession>
    <name>FOLD_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="1">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="1">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="1" type="primary">folD</name>
        <name type="ordered locus">BLA_1499</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="1"/>
    <dbReference type="EC" id="3.5.4.9" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217745.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DUV2"/>
    <dbReference type="SMR" id="B8DUV2"/>
    <dbReference type="STRING" id="442563.BLA_1499"/>
    <dbReference type="EnsemblBacteria" id="ACL29781">
        <property type="protein sequence ID" value="ACL29781"/>
        <property type="gene ID" value="BLA_1499"/>
    </dbReference>
    <dbReference type="GeneID" id="66533331"/>
    <dbReference type="KEGG" id="bla:BLA_1499"/>
    <dbReference type="HOGENOM" id="CLU_034045_3_0_11"/>
    <dbReference type="OMA" id="HIVGRPM"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0486">Methionine biosynthesis</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0554">One-carbon metabolism</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000185596" description="Bifunctional protein FolD">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="168"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <sequence length="297" mass="31127" checksum="3AB0E41C538D0A58" modified="2009-03-03" version="1">MAIVLDGKKVAGQIKADLASRVAGLARMGMVPGLGTVLVGDDPGSMKYVEGKHRDCEEVGIASIRRQLPATATTEDVLAVVRDLNEDPACTGYIIQLPLPAHIDSNAIIGAIDPTKDADGMHPYNLGELVLHVRGDITTPLPCTPRGVLALLDAYGIELAGRNVCVLGRGITIGRTIGLMLTRSGVNATVTLCHTGTRNIEEHIRRADVVIAAVGVAGFVQVEHVKPGAVLIDVGVSRVFDEQAGRMRIVGDVDSEAHAVAGAYSPNPGGVGPMTRAMLLANVVEQAERMAGIREDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUV6</accession>
    <name>B8DUV6_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase</fullName>
            <shortName evidence="7">MECDP-synthase</shortName>
            <shortName evidence="7">MECPP-synthase</shortName>
            <shortName evidence="7">MECPS</shortName>
            <ecNumber evidence="3 7 8">4.6.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">ispF</name>
        <name evidence="10" type="ordered locus">BLA_1503</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP</text>
            <dbReference type="Rhea" id="RHEA:23864"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="4.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the IspF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.12" evidence="3 7 8"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1503"/>
    <dbReference type="EnsemblBacteria" id="ACL29785">
        <property type="protein sequence ID" value="ACL29785"/>
        <property type="gene ID" value="BLA_1503"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1503"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1573"/>
    <dbReference type="HOGENOM" id="CLU_084630_1_0_11"/>
    <dbReference type="OMA" id="QHFGTGR"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008685">
        <property type="term" value="F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00554">
        <property type="entry name" value="MECDP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00107">
        <property type="entry name" value="IspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003526">
        <property type="entry name" value="MECDP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020555">
        <property type="entry name" value="MECDP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036571">
        <property type="entry name" value="MECDP_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43181">
        <property type="entry name" value="PTHR43181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02542">
        <property type="entry name" value="YgbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69765">
        <property type="entry name" value="SSF69765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00151">
        <property type="entry name" value="ispF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01350">
        <property type="entry name" value="ISPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YgbB" evidence="9">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="8"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="58"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="132"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL29785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="161" mass="16776" checksum="037FFA7C07DD72C2" modified="2009-03-03" version="1">MRNGLGFDAHRFADARNPRPFFLACLEWEGNGVEGDSDGDVAVHALIDALSSATGLGDIGTLFGVGADSRGAGMRGEAMLRETLRLVHAHGFEPVSMSISIIGNQPKIGCRRDEAQQRMSQICGCPVGITATTTDGMGFTGRGEGLAAIASVLVRKTVASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUV7</accession>
    <name>B8DUV7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Possible transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217740.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1504"/>
    <dbReference type="EnsemblBacteria" id="ACL29786">
        <property type="protein sequence ID" value="ACL29786"/>
        <property type="gene ID" value="BLA_1504"/>
    </dbReference>
    <dbReference type="GeneID" id="66533336"/>
    <dbReference type="KEGG" id="bla:BLA_1504"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1574"/>
    <dbReference type="HOGENOM" id="CLU_048259_1_2_11"/>
    <dbReference type="OMA" id="DMKVMIP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042215">
        <property type="entry name" value="CarD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CarD_TRCF" evidence="2">
        <location>
            <begin position="2"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="198" mass="22417" checksum="CF58F188BD88FE0A" modified="2009-03-03" version="1">MGYKVGDMVVYPRHGAARVEEILQRTVKGVTREYLKLSVLSSDDLEIFVPVDNLKKVGVRDIVDGDEVSRVFEILRTPIVEKEMNWSRRYKLNVEKIATGDVNNIAEVVRDLSQRDVDEHGLSAGEKRMLTKARSILTSEIALSEELSEEETQRLLDVNLGYAEPQEGDAEHHTEVPEEPAQDTLARLESESKKSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUW3</accession>
    <name>B8DUW3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type transport system involved in resistance to organic solvents, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217732.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1510"/>
    <dbReference type="EnsemblBacteria" id="ACL29792">
        <property type="protein sequence ID" value="ACL29792"/>
        <property type="gene ID" value="BLA_1510"/>
    </dbReference>
    <dbReference type="GeneID" id="66533343"/>
    <dbReference type="KEGG" id="bla:BLA_1510"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1581"/>
    <dbReference type="HOGENOM" id="CLU_534927_0_0_11"/>
    <dbReference type="OMA" id="YGDSEYQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043777">
        <property type="entry name" value="DUF5719"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18986">
        <property type="entry name" value="DUF5719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="514" mass="53139" checksum="1FCB1021C9C37BCC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUW4</accession>
    <name>B8DUW4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015940196.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1511"/>
    <dbReference type="EnsemblBacteria" id="ACL29793">
        <property type="protein sequence ID" value="ACL29793"/>
        <property type="gene ID" value="BLA_1511"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1511"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1582"/>
    <dbReference type="HOGENOM" id="CLU_2285959_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="101" mass="10978" checksum="73DF7E15D4721A22" modified="2009-03-03" version="1">MGFGGIYVVTDGHDASGRASAQLLANITSCSGVQSVVSNAKGTYYRFTLNPPAEQHIDDAGIVEQSHNPWRIAWLWCLGIIVFLYCIVAIPRTHASNEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV16</accession>
    <name>B8DV16_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multidrug transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BLA_0011</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219035.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28317">
        <property type="protein sequence ID" value="ACL28317"/>
        <property type="gene ID" value="BLA_0011"/>
    </dbReference>
    <dbReference type="GeneID" id="66532384"/>
    <dbReference type="KEGG" id="bla:BLA_0011"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.11"/>
    <dbReference type="HOGENOM" id="CLU_001265_10_13_11"/>
    <dbReference type="OMA" id="AMFLRPI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="50"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="440" mass="47462" checksum="4382A4EE63F21089" modified="2009-03-03" version="1">MTAGNNTHRKTSSATDSATDSTQRQSNPSGYTTSAGERAAGKARERLITRDVALIMAATFFYMTSSMMGTPIIAGFSQSLGASGALMGFLAGALSLSALICRPIAGNLSDRTSKRKLAVIGALIFLASNLGYYFVPNTAWLLAARILNGVGFACISVCLSTWLSMLLPISRMGAGMGLYGTMNALAQAVGPDLGIRASKAIGYRNTFLIAVGLTCCIVICVLLIKDGGKPPRARLGRQQGGERHHIRLDSLFEPRVIPIALIFMLFAIPYFANQSFIVDYANARHAHVIVSLFFPCYAITLLISRIVLRNWFDTKSFLFFMVTGTICQIVMLASLTVMRNNWFVMLAGLATVGAYGMMSSVTQARAVLIAGKARSGMANTTYYAGIDLGMFLGPLIGGFLYGGLPIIWFYPALLLTMPVAWIVYAFAHRTIQSSERAPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV39</accession>
    <name>B8DV39_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0035"/>
    <dbReference type="EnsemblBacteria" id="ACL28340">
        <property type="protein sequence ID" value="ACL28340"/>
        <property type="gene ID" value="BLA_0035"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0035"/>
    <dbReference type="HOGENOM" id="CLU_161929_1_2_11"/>
    <dbReference type="OMA" id="WAGAKEC"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004386">
        <property type="entry name" value="Toxin_YafQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15738">
        <property type="entry name" value="YafQ_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="64" mass="7004" checksum="0B2D555BB2BA7059" modified="2009-03-03" version="1">MIENSPASIAVLKQRHNMHTLAGKWQGRNECHVANAGDGPVIWSCNGKVAFFEHTGSHDELFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV50</accession>
    <name>B8DV50_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Hemolysins-like proteins containing CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">BLA_0048</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219322.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0048"/>
    <dbReference type="EnsemblBacteria" id="ACL28351">
        <property type="protein sequence ID" value="ACL28351"/>
        <property type="gene ID" value="BLA_0048"/>
    </dbReference>
    <dbReference type="GeneID" id="66532424"/>
    <dbReference type="KEGG" id="bla:BLA_0048"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.52"/>
    <dbReference type="HOGENOM" id="CLU_015237_4_0_11"/>
    <dbReference type="OMA" id="DLMIPRV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="216"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="279"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACL28351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="451" mass="48898" checksum="302790382335505D" modified="2009-03-03" version="1">MSLGLNILLIFVFLLLGSVFAGTELALVSLRGSQIDQMEQEDARGKRVAKIARDPNTFLSTVQIGVTLSGFLSASFGESSISPFIVPVVEGWGVPSNVAAPLTTIVLTLVISYCSIVISEMVPKRIAMQRNEQIARAVVPAISAFAKVCRPIIWLIGKNTNGIVRLLGFDPNETESEVSDEELRVLVSSNTNLTKDERTILDDVFDASETIVAEVMRPRADVVFLDGDTPLADAAAQVRELPYSRYPVIGKSFDDVLGFVHVRDLLDVRDPNAKTVADVTREGISLPGTSKLLPSLSLLRKRGIHLAVVIDEYGGTDGIVTLEDMTEELVGDIRDEYDLPEDTPKDKLPTDVFVDGVATIDGGMTIEDFADLTGIELEDGPYETVAGYFLAHSGKMGEVGDHLVVDDAYTMTITKVDGRRIETIEVRKGTANGGTEVSDDQQANDPEHSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV51</accession>
    <name>B8DV51_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carbonic anhydrase</fullName>
            <ecNumber evidence="3">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">icfA</name>
        <name evidence="7" type="ordered locus">BLA_0049</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + hydrogencarbonate = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619617.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0049"/>
    <dbReference type="EnsemblBacteria" id="ACL28352">
        <property type="protein sequence ID" value="ACL28352"/>
        <property type="gene ID" value="BLA_0049"/>
    </dbReference>
    <dbReference type="GeneID" id="66532425"/>
    <dbReference type="KEGG" id="bla:BLA_0049"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.53"/>
    <dbReference type="HOGENOM" id="CLU_053879_4_1_11"/>
    <dbReference type="OMA" id="GHEGCGA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="PTHR11002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00704">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL28352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="225" mass="25111" checksum="CDA15E508577B3C3" modified="2009-03-03" version="1">MTDSTQETTANSTWSRMLAGNRRFAEGNAEHPWRDKETRESLIDTQNPDAAVLSCSDSRVPPEIIFDAGLGDMFTVRTAGEMLDQAVLQTLEYAVSSLHVSLLVVLSHQHCAAVAQAEKELDALTEHLTHEITDAQERERIMEDLDEVIASSSSEFLKNIGISVWQARMAGLDSRDDYEQVHIAHTIEQLVTSSEMIRDALAHERLMIVGARYRLDTGLVEVLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV74</accession>
    <name>B8DV74_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0749 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218364.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0072"/>
    <dbReference type="EnsemblBacteria" id="ACL28375">
        <property type="protein sequence ID" value="ACL28375"/>
        <property type="gene ID" value="BLA_0072"/>
    </dbReference>
    <dbReference type="GeneID" id="66532447"/>
    <dbReference type="KEGG" id="bla:BLA_0072"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.76"/>
    <dbReference type="HOGENOM" id="CLU_040273_2_1_11"/>
    <dbReference type="OMA" id="IKVMDQR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010273">
        <property type="entry name" value="DUF881"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37313">
        <property type="entry name" value="PTHR37313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05949">
        <property type="entry name" value="DUF881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="265" mass="28438" checksum="FECF64E0CD0EBF38" modified="2009-03-03" version="1">MAKHGARHVRKTSVVGSMAVLVVVALVGYLVVTNLRVNKSATVSNDAAELIEHRVQRVDELQSEVNKLGSQIDDYNTLLRNNEMQSGNSEEAGQSTMLPAVTGPGVTVTLNDSSMWRSAVDSSGSTADIDKYVVHQQDVEAVVDALWAGGAESMQIMDQRVLPTSAVICSGNVLLLQGRKYSPPFTISAIGPVDGMLQSLDDSRAIQIYKQYVDAFGLGYDVEVNRSLTFQRTPLVLNPLRYAKAFESGGSNESANGGQTTSATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV83</accession>
    <name>B8DV83_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Forkhead-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218378.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0081"/>
    <dbReference type="EnsemblBacteria" id="ACL28384">
        <property type="protein sequence ID" value="ACL28384"/>
        <property type="gene ID" value="BLA_0081"/>
    </dbReference>
    <dbReference type="GeneID" id="66532456"/>
    <dbReference type="KEGG" id="bla:BLA_0081"/>
    <dbReference type="HOGENOM" id="CLU_047963_1_1_11"/>
    <dbReference type="OMA" id="FKSEVQP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022128">
        <property type="entry name" value="FhaA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042287">
        <property type="entry name" value="FhaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12401">
        <property type="entry name" value="DUF3662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="156"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="233" mass="25618" checksum="93DFC6AB0C52F76E" modified="2009-03-03" version="1">MSVLDRFEKSVEGAVNGVFAKFGSKDLQPVDLSSALEREIDAEAMPVGRDRTVAPNEYRFKLSTPDFDRIESWGSEAMANELADNLTQYAKSQHYAFVGPVVVIFEEDLQLTKGNFKLTSESVQGNAVPVTTDEQAEDCPMLEVNNNQYLLTKDKTILGRGSGCDIVIDDPGISRKHLEIDITDNGVIARDLGSTNGTYVEGHQVPAATLLDGNTITIGRTRILYWASSQDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV95</accession>
    <name>B8DV95_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218390.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0093"/>
    <dbReference type="EnsemblBacteria" id="ACL28396">
        <property type="protein sequence ID" value="ACL28396"/>
        <property type="gene ID" value="BLA_0093"/>
    </dbReference>
    <dbReference type="GeneID" id="66532469"/>
    <dbReference type="KEGG" id="bla:BLA_0093"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.99"/>
    <dbReference type="HOGENOM" id="CLU_528603_0_0_11"/>
    <dbReference type="OMA" id="WDSDMED"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045425">
        <property type="entry name" value="DUF6508"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20118">
        <property type="entry name" value="DUF6508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="509" mass="58929" checksum="07B5B23BA969A3F6" modified="2009-03-03" version="1">MEDFEFLHEHEKGFEPSGEFIESRSKVPILEYGMDYYCFADIVIGPVLPAVYLTNPLFATDNEGKPHYYGRERVGRYPGGTWWDWGPDEPKSSTMRIEPVPISPVNVMGETVVPYERWVESYRNLPGTPFYSSLDDSGDYCDKASVFDPHGREAYRRAMFYMEEAMRVHRAYSDEDERQRFHDCVKLAEILFRHAAGRGDARAWVALGKIYKEDLNNGDYFNSYYTASIKGHPPMIEQPPIGERARICFERAAELGDPEALVFLGDLRIEGMVCERDESAAFELYRRAYALVDERHAMHYIKASAALRLARCLEYGVGCEIDLMQARDLYRFAHTYLRAIARTYFWWFARERREAMAHDQDLTQLLSHPSHVQRVALSRMGTPHPYESVTKFLPMLESMGEFGDVVNPFYVSYNGIVLRFMDEVNRVLDRQPDLGFFDYLGLLHAKLLDAPIDVVDPADYDARTVMAMIIYVVRQEKFGEGLMLHSLNHGLIQRWLRRLVQIDDERASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV99</accession>
    <name>B8DV99_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BLA_0097</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218394.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0097"/>
    <dbReference type="EnsemblBacteria" id="ACL28400">
        <property type="protein sequence ID" value="ACL28400"/>
        <property type="gene ID" value="BLA_0097"/>
    </dbReference>
    <dbReference type="GeneID" id="66532474"/>
    <dbReference type="KEGG" id="bla:BLA_0097"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.103"/>
    <dbReference type="HOGENOM" id="CLU_035990_6_2_11"/>
    <dbReference type="OMA" id="FYESHAT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018142">
        <property type="term" value="P:protein-DNA covalent cross-linking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="SSF143081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL28400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="213" mass="24086" checksum="C47C59143C8E35A4" modified="2009-03-03" version="1">MCAHYLGLTDAELERLVDELTMQCQRSRARVGADDEFAGVGVEAYPKSVVPIIVPKFDTAVGVPELEPGSLETARAQWGFEQQWTPQPVFNTRIESADKPMWRAPMEHDRCVIACRWFYESHGSEMAVSARTGRKIKQQYVFRVPDEPVMLIGGVRRGSQFSMVTTQANADMEPIHPRMPLIVRQGELDLWLGPDYRALADRSDIPLESKPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVA6</accession>
    <name>B8DVA6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0104"/>
    <dbReference type="EnsemblBacteria" id="ACL28407">
        <property type="protein sequence ID" value="ACL28407"/>
        <property type="gene ID" value="BLA_0104"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0104"/>
    <dbReference type="HOGENOM" id="CLU_679103_0_0_11"/>
    <dbReference type="OMA" id="YSERNIK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="456" mass="50222" checksum="363F2B6E1F027436" modified="2009-03-03" version="1">MGRERQSQETARGNGFHRVRAIIIACVVVIGLLAGVAVRLSTWWHAYRVPSMTGQTIARVSADSSVTDDVSQWYSQWKGRRQEIGVAPQYQLSSVRIRTVQRLPNIASRYDQSDGRNIYVRLDATVRPRFASIQRITDVHGCQTYAVESGINESCVFTSEPRQDGYRIAQVMEPIMYQRLAYPEQFEKTEPDPTAPVLDGRNGYRLSKERLEVTYDGGTTWREVPDGVARIVGGINANTTLWLEPSRYVITPQFTAFVGYDEGTHTAQLLYSWDAGSTWLTSALGHGVQAPSYISVVGDRIGVAYGYGDTLGSVGYAMVAGTLPELRADAEAVWRQIPMYMQYPSDLTMAGWVNDTTVIVGQAGSLHVSSDSGATWRELGIPKEPGLEGKLGYYPFDTPTHVWVEDGTAYLAMGQGEDADYAPNGTVVEAVFSYDPATDACTFIRQQPAPTPMPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVB7</accession>
    <name>B8DVB7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted nucleoside-diphosphate-sugar epimerases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218413.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0115"/>
    <dbReference type="EnsemblBacteria" id="ACL28418">
        <property type="protein sequence ID" value="ACL28418"/>
        <property type="gene ID" value="BLA_0115"/>
    </dbReference>
    <dbReference type="GeneID" id="66532490"/>
    <dbReference type="KEGG" id="bla:BLA_0115"/>
    <dbReference type="HOGENOM" id="CLU_025711_0_3_11"/>
    <dbReference type="OMA" id="RLRPPCN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="10"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="262" mass="28622" checksum="4DF84CDAE62AEFEB" modified="2009-03-03" version="1">MKPTHVLVVGASGSIGRHAVEKARAAGYRVRALVRDPSRIHFGCGVEVVQGDLTSVESMRQALDGIDGIVFTHGSNGGPTLTETVDYGAVRNALEALDGRPARIALMTSIGVTNMDNDYNRSTEAHDWKRHSERLVRASGNEYTIVRPGWFDMEGADEHQLKFEQGDRRDPMGPQDGSAARRQVAQTLVDALGCKEADHKTLELIDVAGTAQTDAELASMFAALQPDTGLDGVLDRDNFPECTQPKRVREQIARIETMRAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVC8</accession>
    <name>B8DVC8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type branched-chain amino acid transport systems ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">livF</name>
        <name evidence="5" type="ordered locus">BLA_0126</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218424.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0126"/>
    <dbReference type="EnsemblBacteria" id="ACL28429">
        <property type="protein sequence ID" value="ACL28429"/>
        <property type="gene ID" value="BLA_0126"/>
    </dbReference>
    <dbReference type="GeneID" id="66532501"/>
    <dbReference type="KEGG" id="bla:BLA_0126"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.132"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OMA" id="MARALMM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="30"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="63"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="271" mass="29527" checksum="4842696968A1A446" modified="2009-03-03" version="1">MPDTATLTPTEAPDVSTLDRSHIHAGEPLLDADNLVAGYLPGVNILNGASLTLHDGEIVGIIGPNGAGKSTLLKSLFGLVHIHSGKLTLKGQDITNLRADKLVSRGVGFVPQTENVFPSLTIAENMHMGAYQAPKLFNERFDYVCSIFPKLGDRRNQLAGQLSGGERQMVAMGRALMMQPSVLLLDEPSAGLSPMMQDETFIRVRQVNKAGVSVVIVEQNARRCLQICDRGYVLDQGRNAYSCRGRDLMNDPKVISLYLGNLEEEVEKENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVD2</accession>
    <name>B8DVD2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sucrose symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">scrT</name>
        <name evidence="7" type="ordered locus">BLA_0130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0130"/>
    <dbReference type="EnsemblBacteria" id="ACL28433">
        <property type="protein sequence ID" value="ACL28433"/>
        <property type="gene ID" value="BLA_0130"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0130"/>
    <dbReference type="HOGENOM" id="CLU_040011_0_0_11"/>
    <dbReference type="OMA" id="RYYGFFE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="13"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL28433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="433" mass="46104" checksum="B989D20AC634C574" modified="2009-03-03" version="1">MVSADGHRPTKAELVRLGIGFTVSAVACAIPWVALSTVILPRVFELIDNSSKEAMLGLVNSIGAIVALLANIIFGTLSDMTRSRFGKRTPWIVGGGIITGLAIGAIAFTRNEALIIFLWCVAQMGYNMMLAPYVAVMSDRVPDKVRGTISGFYGAGIAVGQTLGSVVGAAFLRQGQSGLFSAWMMGLGIFSLTGIFVVAMWPREKSSRFEEQSEHVTVKSVLLNFRPPRHAPDFYYALVGRTLMMGGYWMITTYQLYIAQDYIYAGDPNAKDKAATIIATMGVITLVVSLIAAVTAGPITDRLGRRKLPVALASCLFAVGAAMPLFFRSPMGMYLFAAVAGLGYGVYNAIDQALNVAVLPNPKEAGKDLGILNLANTLSTVIGTAMTSLVVSIVKSSMHVSTTPAVAYAWVFGVAIVIVLAAAALIMRIRNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVF4</accession>
    <name>B8DVF4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Large transmembrane protein possibly involved in transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0152"/>
    <dbReference type="EnsemblBacteria" id="ACL28455">
        <property type="protein sequence ID" value="ACL28455"/>
        <property type="gene ID" value="BLA_0152"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0152"/>
    <dbReference type="HOGENOM" id="CLU_005531_0_1_11"/>
    <dbReference type="OMA" id="NFIWKRM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038766">
        <property type="entry name" value="Membrane_comp_ABC_pdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30287">
        <property type="entry name" value="PTHR30287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="487"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="536"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="611"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="858"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="914"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="953"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="319"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="991" mass="107003" checksum="17B4E7460A7D9E35" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVI7</accession>
    <name>B8DVI7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC1 family protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0186</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0186"/>
    <dbReference type="EnsemblBacteria" id="ACL28488">
        <property type="protein sequence ID" value="ACL28488"/>
        <property type="gene ID" value="BLA_0186"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0186"/>
    <dbReference type="HOGENOM" id="CLU_006533_0_2_11"/>
    <dbReference type="OMA" id="ADTFRRN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="543"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="567"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="169"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="606" mass="66950" checksum="BD3B6E02A984DCC7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVK5</accession>
    <name>B8DVK5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aspartokinase</fullName>
            <ecNumber evidence="4">2.7.2.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">askB</name>
        <name evidence="4" type="ordered locus">BLA_0204</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="4"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0204"/>
    <dbReference type="EnsemblBacteria" id="ACL28506">
        <property type="protein sequence ID" value="ACL28506"/>
        <property type="gene ID" value="BLA_0204"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0204"/>
    <dbReference type="HOGENOM" id="CLU_009116_4_1_11"/>
    <dbReference type="OMA" id="VNVLMIS"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="3">
        <location>
            <begin position="27"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="3">
        <location>
            <begin position="107"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="180" mass="18620" checksum="B49BF430679CF42F" modified="2009-03-03" version="1">MGDLFPDLGQETPIISGVAHDNSESLVTVRGVTDEPGMAGRVFTRLAELGVNVDMIVQAGASTGTADISFTIPGSDAARVETALTAAQDTLGYKSFDVNPNVGKVAVVGVGMKTHSGLAARFFQALSEEGINVLMISTSEIRIAALVPLSQLNDAVRALHSAYGLDADKVEAVVYGGTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVM7</accession>
    <name>B8DVM7_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="9">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">gltX</name>
        <name evidence="13" type="ordered locus">BLA_0226</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="9"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619672.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0226"/>
    <dbReference type="EnsemblBacteria" id="ACL28528">
        <property type="protein sequence ID" value="ACL28528"/>
        <property type="gene ID" value="BLA_0226"/>
    </dbReference>
    <dbReference type="GeneID" id="66532600"/>
    <dbReference type="KEGG" id="bla:BLA_0226"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.238"/>
    <dbReference type="HOGENOM" id="CLU_015768_6_1_11"/>
    <dbReference type="OMA" id="WDEGPFF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020752">
        <property type="entry name" value="Glu-tRNA-synth_I_codon-bd_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="11">
        <location>
            <begin position="19"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_2" evidence="12">
        <location>
            <begin position="360"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="270"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACL28528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="516" mass="57626" checksum="141B5AA091A0910C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVP0</accession>
    <name>B8DVP0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BLA_0239</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268327.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0239"/>
    <dbReference type="EnsemblBacteria" id="ACL28541">
        <property type="protein sequence ID" value="ACL28541"/>
        <property type="gene ID" value="BLA_0239"/>
    </dbReference>
    <dbReference type="GeneID" id="66532615"/>
    <dbReference type="KEGG" id="bla:BLA_0239"/>
    <dbReference type="HOGENOM" id="CLU_072498_0_0_11"/>
    <dbReference type="OMA" id="VGWWIIN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL28541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="274" mass="29268" checksum="11F071F6486542C4" modified="2009-03-03" version="1">MEHVLDWLKANSGRIIFLAIVIALAFVVTRLLSRGLRKVLEHNKIPQASIFINIARVLVWVVALTIVLHPVFGVSPASLFTALGIGGLAISLGLKDSIANTIGGFTLMFSHVIQPGDTVSINDTTGVVQDINWRQTVVRERNGNLMMIPNSVLNTTALEKLDPANECLVTIPFTAKPDVDTAKLAQDLLSTVNTHARSLMNPKYKAVVRYTGFTSDGVSGNIVAYAKHGVALTALSDAIARAVHSSKLNLNFTASSLVGIDESGALTGKSTSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVP7</accession>
    <name>B8DVP7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable PfkB family carbohydrate (Sugar) kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268342.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0246"/>
    <dbReference type="EnsemblBacteria" id="ACL28548">
        <property type="protein sequence ID" value="ACL28548"/>
        <property type="gene ID" value="BLA_0246"/>
    </dbReference>
    <dbReference type="GeneID" id="66532622"/>
    <dbReference type="KEGG" id="bla:BLA_0246"/>
    <dbReference type="HOGENOM" id="CLU_027634_7_0_11"/>
    <dbReference type="OMA" id="IGGCALN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="22"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="351" mass="37558" checksum="D1CA34737439B3B7" modified="2009-03-03" version="1">MLSDILHSIQAKRDHEPTVISLGQVWVDSMIKVPEFPAPGSFMNAESIARSVNGSFAVLEAASRMGAQTELAGILGTGPWSDMIRRALKRVNVRHTGITNKGLDNGLRLVINDGQERSFISAPGAEVRTDAHTFDDMHPKSGDVVHISGASLMNTGAVAVGSFISRPECAPDVRDFRIVLTPTSMMSTVNERLLEDIVLLHPIWVLNRQQGRAIADRLGIEVDETATMRVDGGFDDSMSALCDGLADVLRAPVVLRAGSRGAWVRRHGEPVQHIDGFETKATHIRSAGPTHTGALCALLANGWNLESAVQIANAAASIAITKGINGVPQCPTYDEAVALVTKALKDAEHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVQ0</accession>
    <name>B8DVQ0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rhs family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0249</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0249"/>
    <dbReference type="EnsemblBacteria" id="ACL28551">
        <property type="protein sequence ID" value="ACL28551"/>
        <property type="gene ID" value="BLA_0249"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0249"/>
    <dbReference type="HOGENOM" id="CLU_227350_0_0_11"/>
    <dbReference type="OMA" id="FSGRCEK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3050">
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022464">
        <property type="entry name" value="Strep_pil_isopept_link"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038174">
        <property type="entry name" value="Strep_pil_link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12892">
        <property type="entry name" value="FctA"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03786">
        <property type="entry name" value="strep_pil_rpt"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2557"/>
            <end position="2577"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="144"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2521"/>
            <end position="2549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="2582" mass="276562" checksum="486408E633A5FF84" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVR5</accession>
    <name>B8DVR5_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Acetolactate synthase</fullName>
            <ecNumber evidence="4 8">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ilvB</name>
        <name evidence="12" type="ordered locus">BLA_0264</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 8"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0264"/>
    <dbReference type="EnsemblBacteria" id="ACL28566">
        <property type="protein sequence ID" value="ACL28566"/>
        <property type="gene ID" value="BLA_0264"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0264"/>
    <dbReference type="HOGENOM" id="CLU_013748_1_3_11"/>
    <dbReference type="OMA" id="CFGTSGP"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="11">
        <location>
            <begin position="32"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="9">
        <location>
            <begin position="223"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="10">
        <location>
            <begin position="421"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACL28566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="642" mass="68908" checksum="0B61DD1B10974836" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVY4</accession>
    <name>RL10_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplJ</name>
        <name type="ordered locus">BLA_0333</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268511.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DVY4"/>
    <dbReference type="SMR" id="B8DVY4"/>
    <dbReference type="STRING" id="442563.BLA_0333"/>
    <dbReference type="EnsemblBacteria" id="ACL28635">
        <property type="protein sequence ID" value="ACL28635"/>
        <property type="gene ID" value="BLA_0333"/>
    </dbReference>
    <dbReference type="GeneID" id="66532712"/>
    <dbReference type="KEGG" id="bla:BLA_0333"/>
    <dbReference type="HOGENOM" id="CLU_092227_1_0_11"/>
    <dbReference type="OMA" id="VRDQKQA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002363">
        <property type="entry name" value="Ribosomal_L10_eubac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01109">
        <property type="entry name" value="RIBOSOMAL_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000195528" description="50S ribosomal protein L10">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00362"/>
        </source>
    </evidence>
    <sequence length="173" mass="18812" checksum="1CE983CAC8807EB0" modified="2009-03-03" version="1">MKRPEKEAVVAELTEQFRNASAVYLTEYRGLTVPQISDLREKLGRDTSYTVAKNTLFRIAAKEAGIEGLDEMLKGPSAVVFVDGDFIEAAKVLRDFAKTNKALIVKGGFADGTVYDAEGAKQLADLKSRPELLAELAGALKGTMSKAAYLFNALPTKVVRTIDALRDKQEKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW04</accession>
    <name>B8DW04_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">4-alpha-glucanotransferase</fullName>
            <ecNumber evidence="3 7">2.4.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Amylomaltase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 7">Disproportionating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">malQ</name>
        <name evidence="8" type="ordered locus">BLA_0353</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the disproportionating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="3 7"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268554.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0353"/>
    <dbReference type="CAZy" id="GH77">
        <property type="family name" value="Glycoside Hydrolase Family 77"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28655">
        <property type="protein sequence ID" value="ACL28655"/>
        <property type="gene ID" value="BLA_0353"/>
    </dbReference>
    <dbReference type="GeneID" id="66532736"/>
    <dbReference type="KEGG" id="bla:BLA_0353"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.379"/>
    <dbReference type="HOGENOM" id="CLU_022072_1_0_11"/>
    <dbReference type="OMA" id="GPVGQNW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102500">
        <property type="term" value="F:beta-maltose 4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003385">
        <property type="entry name" value="Glyco_hydro_77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32438">
        <property type="entry name" value="PTHR32438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02446">
        <property type="entry name" value="Glyco_hydro_77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00217">
        <property type="entry name" value="malQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="722" mass="81241" checksum="C21D634F4154F350" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW11</accession>
    <name>B8DW11_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0360"/>
    <dbReference type="EnsemblBacteria" id="ACL28662">
        <property type="protein sequence ID" value="ACL28662"/>
        <property type="gene ID" value="BLA_0360"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0360"/>
    <dbReference type="HOGENOM" id="CLU_064238_1_0_11"/>
    <dbReference type="OMA" id="MRERKNP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025576">
        <property type="entry name" value="YwiC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14256">
        <property type="entry name" value="YwiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="261" mass="28608" checksum="A3B1788F2EBBAC19" modified="2009-03-03" version="1">MRDWRSNEPGAWVIVLMPALSAFLVSGPTWNSVWLLVLWCLCYCVQFSAARWAKSHGRARYRMPMLVYAALLVCAGLPFVFRFPGMLWWAPIYCVLCAGSLICAWRRREHSIPANICAVLASSTMAIPVASLGTHGGDAPALAHLLPFGQSILPPLGVEIAGAYALTLFGSVLYVKTMIREQGNTRYLAASWIWHILVMAIGFLYSPIYGWLGAILLARAVVMPVATRNMRKTAKIAGIGECVTSLVSFVMITYAATVLIP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW18</accession>
    <name>RL22_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplV</name>
        <name type="ordered locus">BLA_0367</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="1">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269021.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DW18"/>
    <dbReference type="SMR" id="B8DW18"/>
    <dbReference type="STRING" id="442563.BLA_0367"/>
    <dbReference type="PRIDE" id="B8DW18"/>
    <dbReference type="EnsemblBacteria" id="ACL28669">
        <property type="protein sequence ID" value="ACL28669"/>
        <property type="gene ID" value="BLA_0367"/>
    </dbReference>
    <dbReference type="GeneID" id="66532750"/>
    <dbReference type="KEGG" id="bla:BLA_0367"/>
    <dbReference type="HOGENOM" id="CLU_083987_3_3_11"/>
    <dbReference type="OMA" id="KRIQPRA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_L22/L17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000166045" description="50S ribosomal protein L22">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <sequence length="119" mass="13309" checksum="3FDAFEDE00FE6438" modified="2009-03-03" version="1">MEAKAIARHVRVTPRKARRMVDLIRGKKATEAITILKFAPQDASTPVLKVLQSAIANARVKADKAGEPFRENDLYIKETYVDEGVTLKRFRARAQGRAARINKRTSHITVVVASKEGDR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW27</accession>
    <name>RS8_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsH</name>
        <name type="ordered locus">BLA_0376</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268594.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DW27"/>
    <dbReference type="SMR" id="B8DW27"/>
    <dbReference type="STRING" id="442563.BLA_0376"/>
    <dbReference type="EnsemblBacteria" id="ACL28678">
        <property type="protein sequence ID" value="ACL28678"/>
        <property type="gene ID" value="BLA_0376"/>
    </dbReference>
    <dbReference type="GeneID" id="66532759"/>
    <dbReference type="KEGG" id="bla:BLA_0376"/>
    <dbReference type="HOGENOM" id="CLU_098428_0_1_11"/>
    <dbReference type="OMA" id="FDQGYIL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_B">
        <property type="entry name" value="Ribosomal_S8_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000165308" description="30S ribosomal protein S8">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <sequence length="132" mass="14481" checksum="FADAB87AFDD8B291" modified="2009-03-03" version="1">MTMTDPIADMLTRLRNASAAKHETVDMPYSKFKKNIAEILKREGYIADFTAKEARVGQTLEVTLKYGPHGERSIQGIKRVSKPGLRRYAKSDALPMPLGGLGIAIISTSSGLLTQKECLDRGIGGEIVAYVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW47</accession>
    <name>B8DW47_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA repair protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">radA</name>
        <name evidence="8" type="ordered locus">BLA_0396</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RecA family. RadA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268631.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0396"/>
    <dbReference type="MEROPS" id="S16.A04"/>
    <dbReference type="EnsemblBacteria" id="ACL28698">
        <property type="protein sequence ID" value="ACL28698"/>
        <property type="gene ID" value="BLA_0396"/>
    </dbReference>
    <dbReference type="GeneID" id="66532780"/>
    <dbReference type="KEGG" id="bla:BLA_0396"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.424"/>
    <dbReference type="HOGENOM" id="CLU_018264_0_1_11"/>
    <dbReference type="OMA" id="FELMRLA"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01498">
        <property type="entry name" value="RadA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004504">
        <property type="entry name" value="DNA_repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041166">
        <property type="entry name" value="Rubredoxin_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18073">
        <property type="entry name" value="Rubredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RECA_2" evidence="7">
        <location>
            <begin position="77"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Lon-protease-like" evidence="5">
        <location>
            <begin position="385"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="RadA KNRFG motif" evidence="5">
        <location>
            <begin position="286"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="106"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="491" mass="51596" checksum="60A7625C33E9FEC5" modified="2009-03-03" version="1">MAKKTVNYVCTECGWSGGKWYGRCPECGQWGTIEEFHEAPAATGARTPAPGRTSRTPISVPNVQSAAKPITSISTDTVNRLPTGFGEFDRVLGGGIVPGSVVLIAGEPGIGKSTLLLETAGNIAKSVAAAHSRTPDGSDSEPHDAHAGTHDSVLYISGEESQAQVRLRASRIGAVEENLLLAATTDLSTVLGLIDSVRPALAIVDSAQTIVSQDVDGISGGSTQVREVASALIDSAKSLDVPVLLVGHVTKDGSIAGPRTLEHLVDVVCQFEGESQTALRLLRAVKNRFGPTDEVGCFDMSGEGIEEVRDPAGLFLSSQNEPVEGTCVTFTLDGHRSLAVEVQSLVTNSVLPTPRRAVNGVDPSRIAMLVAVLYRHGGISLLQNDLYISTIAGGQAKEPGCDLAITAAMASAALNKPIAKNVCAIGEISLTGQVRPVPRLEYRLREAQRLGFTKAIVPATQKPLKMEGMTLAPATNLKDALAFLHLAKQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW78</accession>
    <name>B8DW78_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">phoU</name>
        <name evidence="5" type="ordered locus">BLA_0428</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PhoU family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268709.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0428"/>
    <dbReference type="EnsemblBacteria" id="ACL28729">
        <property type="protein sequence ID" value="ACL28729"/>
        <property type="gene ID" value="BLA_0428"/>
    </dbReference>
    <dbReference type="GeneID" id="66532813"/>
    <dbReference type="KEGG" id="bla:BLA_0428"/>
    <dbReference type="HOGENOM" id="CLU_078518_1_0_11"/>
    <dbReference type="OMA" id="WKHGIET"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="4">
        <location>
            <begin position="16"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="4">
        <location>
            <begin position="134"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="226" mass="25288" checksum="56E78D575E1E8534" modified="2009-03-03" version="1">MRVIFNEGLKAVADDLDHMARDVRDAIRLAGEALLHQDLDAAQTVIDNDASIDDLSTRIMDQCVELLARQNPVATDLRVIVSTMRLATTFERMGDLARHIAESARRTYPNSPVPQNLVPTFAKMQQFLDITGGRLVDMLADRDTAIAEQIIRDDDQLDDLHLKIMQYADSAEWEGTNEQLINVVLIARFMERLGDHAVSAARRVVFIVSGFDPTKTPSRDEGTDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW86</accession>
    <name>B8DW86_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Low molecular weight protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ptpA</name>
        <name evidence="4" type="ordered locus">BLA_0436</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619723.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0436"/>
    <dbReference type="EnsemblBacteria" id="ACL28737">
        <property type="protein sequence ID" value="ACL28737"/>
        <property type="gene ID" value="BLA_0436"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0436"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.465"/>
    <dbReference type="HOGENOM" id="CLU_071415_2_1_11"/>
    <dbReference type="OMA" id="TGSWHVG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="3">
        <location>
            <begin position="8"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="178" mass="20289" checksum="4328A710986E330B" modified="2009-03-03" version="1">MGTKPQPYTVMTVCTGNICRSPMAEIILRHEFEERGLGDRARVESSGVSSEEHGNPIDRRAVKVLREHGYDIPPEHFAHRITPNEIAETNLFLPMTASHMGALMHMLPLSKRSHVFMYRSFDPNLPDPQPGRESDIDLVDPWYGGQRDFEISIDQIEEVAPYIVDYVEKQLEAQDATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DW99</accession>
    <name>B8DW99_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0449</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268762.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0449"/>
    <dbReference type="EnsemblBacteria" id="ACL28750">
        <property type="protein sequence ID" value="ACL28750"/>
        <property type="gene ID" value="BLA_0449"/>
    </dbReference>
    <dbReference type="GeneID" id="66532834"/>
    <dbReference type="KEGG" id="bla:BLA_0449"/>
    <dbReference type="HOGENOM" id="CLU_054007_0_0_11"/>
    <dbReference type="OMA" id="MRLGYNV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024534">
        <property type="entry name" value="DUF2220"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024537">
        <property type="entry name" value="DUF3322"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09983">
        <property type="entry name" value="DUF2220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11795">
        <property type="entry name" value="DUF3322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3322" evidence="3">
        <location>
            <begin position="11"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2220" evidence="2">
        <location>
            <begin position="201"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="406" mass="44846" checksum="2C81D54E0141F80F" modified="2009-03-03" version="1">MTDTATLKTPADVRGDVARIVQRELFAAESPWPRTIHIPWPKETQLVADVAGVHAANNALKEFAARFGCQTDFISRKMGTAVSLVAHIHVPDEATALAIAGPTLRRPRERVLARAAQLEQRCHVDHALAMDVVRRLNNESDVDFGLFVEAAQWFGRHWAEVPGLTAREIPLPGFSAKWLAGSRSRRRAAICTVLGVDRLPLRERPGEVRYRYMDQRFAAEPDRVATSVQCVPERPVSLAVIVENKDTYQAMGPIDGAVCVFGSGFAVNRVPELLPWLAGDGVRVVYWGDIDAAGFEILSGLRASGVACESVLMDRMTYAEYERFGTTRDAASHEIRCGEPKHGLHLSPEEYALYRDLCTGELAVPRIEQERIPIAEFMRLISAGRSDGSDGARADQCHSQSLRTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWA3</accession>
    <name>B8DWA3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_0455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268769.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0455"/>
    <dbReference type="EnsemblBacteria" id="ACL28754">
        <property type="protein sequence ID" value="ACL28754"/>
        <property type="gene ID" value="BLA_0455"/>
    </dbReference>
    <dbReference type="GeneID" id="66532838"/>
    <dbReference type="KEGG" id="bla:BLA_0455"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.484"/>
    <dbReference type="HOGENOM" id="CLU_037628_1_0_11"/>
    <dbReference type="OMA" id="VYTEFMG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="331" mass="36268" checksum="CAE707013B1553E0" modified="2009-03-03" version="1">MVTRKDIAEQAGVSQSTVSRLLNGDPTLKVKADTRRRIMRTAAELGYRAFTSRSIAVLNVPPQFDELQDAYFQSLQTELRKVAAEQGTTLTFFDSIDSLIAHADDHDGFVATGPTSFQRTDLAHLRDALRYGVFIDTNPAPDWFDSVRPDLSQTMLDALDTLLVDGYTCIGYIGGVGSIMGLHNHTEDIRSLAFSDWSKRLGLPNEQYIYADGPFTVSNGRALAARLLTDHPDDLPNALVIGSDPMAVGVLQAFAEAGVRVPTDIAVVSVDNLPIAQYTAPPLSSYAIDLHELVYAALTTLTDAIARDRHVRRHVLLSTELVRRESLPSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWB8</accession>
    <name>B8DWB8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0470"/>
    <dbReference type="EnsemblBacteria" id="ACL28769">
        <property type="protein sequence ID" value="ACL28769"/>
        <property type="gene ID" value="BLA_0470"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0470"/>
    <dbReference type="HOGENOM" id="CLU_025319_1_0_11"/>
    <dbReference type="OMA" id="GWAVMPL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="477"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="508"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="554" mass="59667" checksum="5CF4FF55095AB993" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWE7</accession>
    <name>B8DWE7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein-tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218195.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0499"/>
    <dbReference type="EnsemblBacteria" id="ACL28798">
        <property type="protein sequence ID" value="ACL28798"/>
        <property type="gene ID" value="BLA_0499"/>
    </dbReference>
    <dbReference type="GeneID" id="66533630"/>
    <dbReference type="KEGG" id="bla:BLA_0499"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.529"/>
    <dbReference type="HOGENOM" id="CLU_057546_0_0_11"/>
    <dbReference type="OMA" id="YIFRSGM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="256" mass="28882" checksum="A5D3542F7115A2B6" modified="2009-03-03" version="1">MRVVSRKLPLPTVENCRDLGGIHTEQGRMVRPGLLVRSANLHDARHDDLETLAHRGISNVIDLRTDPERDLKPDRLLEDWSFYALPTFRETKALRLQLRDIVTRPGTFIEDLYPRLVLDDAAVACWKRMFRLLIDEPGGYLFHCTQGKDRTGIAAALILAALEVPEDVIRDDYLQTNLYMSTEMPAFVDTFEALLGPKAHADIDEFLVASPLYFQTYIDATASFGGPVGYLRTAIGLSEADLRALRDFYLTDDASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWF5</accession>
    <name>B8DWF5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Possible XorII very-short-patch-repair endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">vsr</name>
        <name evidence="7" type="ordered locus">BLA_0507</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the Vsr family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218204.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28806">
        <property type="protein sequence ID" value="ACL28806"/>
        <property type="gene ID" value="BLA_0507"/>
    </dbReference>
    <dbReference type="GeneID" id="66533637"/>
    <dbReference type="KEGG" id="bla:BLA_0507"/>
    <dbReference type="HOGENOM" id="CLU_111913_1_0_11"/>
    <dbReference type="OMA" id="HDCYLFK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00221">
        <property type="entry name" value="Vsr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004603">
        <property type="entry name" value="DNA_mismatch_endonuc_vsr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03852">
        <property type="entry name" value="Vsr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00632">
        <property type="entry name" value="vsr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL28806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="170" mass="19939" checksum="552E30297758DFFA" modified="2009-03-03" version="1">MNKARKGAQWYARTIHCPGDTGGVAQSPSHPESPYARGTRSYTMSRIRGKDTSIEKTVRSYLFARGFRFRKNDKRYPGHPDIVLPKYRTIVFVNGCFWHMHEGCESFHMPKSNVEFWAAKLTRNRDRDRRQHEQLRQMGWRVIDVWECELRGDAREARLERLVGQIAEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWI9</accession>
    <name>B8DWI9_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C-terminal fibronectin type III domain-containing protein</fullName>
            <ecNumber evidence="6">3.1.3.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_0541</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.48" evidence="6"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0541"/>
    <dbReference type="EnsemblBacteria" id="ACL28840">
        <property type="protein sequence ID" value="ACL28840"/>
        <property type="gene ID" value="BLA_0541"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0541"/>
    <dbReference type="HOGENOM" id="CLU_001730_1_0_11"/>
    <dbReference type="OMA" id="NNHRCTH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870842" evidence="4">
        <location>
            <begin position="22"/>
            <end position="1943"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="1449"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="1542"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1525"/>
            <end position="1550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL28840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="1943" mass="205157" checksum="67A54AB4CFEDEA75" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWJ7</accession>
    <name>B8DWJ7_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269224.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0549"/>
    <dbReference type="EnsemblBacteria" id="ACL28848">
        <property type="protein sequence ID" value="ACL28848"/>
        <property type="gene ID" value="BLA_0549"/>
    </dbReference>
    <dbReference type="GeneID" id="66533679"/>
    <dbReference type="KEGG" id="bla:BLA_0549"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.578"/>
    <dbReference type="HOGENOM" id="CLU_075791_0_1_11"/>
    <dbReference type="OMA" id="FTARIVH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="221" mass="23811" checksum="45BDDAD032ABF434" modified="2009-03-03" version="1">MSSPQSPRRGTTRTTGGRKRMTAAERKRLYRRRRIVFFSALAVVLALAVFTVYSLVRGAVSVHGMAGASAAPALSRAEVPAAPQRSKVETCTPGDVDVQLVPDATSVGVGGSLDFTERVAYVGKSPEGCRMNTAADSLVLTITSGSDVIWRSDVCEAAYRPRLFFADVTDEQKIAWNTNRTGTSCVADDQLPKVDRGTYVAQLSLKDDPKVQSKPQTITVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWJ8</accession>
    <name>B8DWJ8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Probable A/G-specific adenine glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">mutY</name>
        <name evidence="12" type="ordered locus">BLA_0550</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AD011</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0550"/>
    <dbReference type="EnsemblBacteria" id="ACL28849">
        <property type="protein sequence ID" value="ACL28849"/>
        <property type="gene ID" value="BLA_0550"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0550"/>
    <dbReference type="HOGENOM" id="CLU_012862_2_0_11"/>
    <dbReference type="OMA" id="WNNAIME"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="PTHR42944"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="11">
        <location>
            <begin position="99"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACL28849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="354" mass="39146" checksum="B9D9B5F48C905473" modified="2009-03-03" version="1">MVTAYCGQSTVRPCRSGQSAVRCCAMVSDMADASPRTKSRKRAQATPEQTVGERRARELERSARQALRELATWWQTSARDLPWRYGRTTPWGVLVCEVMSQQTQMSRVVPYWEAWMSQWPDAASLAAAEKSEVIRAWGRLGYPRRALRLQECAEVVARDYDDRLPREYDELMALPSVGDYTASAVLSFAYGERVAVIDTNIRRALSRAFLGVESLGGSCTPLERALAWVVLPKAVEQSVLWNQAVMELGALVCTAKAPQCEQCPLQPQCEFVKAGMPGLGEKRTRPRQRFHGTDRQVRGSILQALRALPAGGALTHAQAEGLCADAVQLDRCIASLDDDGLIEILPGHAMRLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWJ9</accession>
    <name>B8DWJ9_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative tRNA (cytidine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.207</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (cytidine/uridine-2'-O-)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yibK</name>
        <name evidence="4" type="ordered locus">BLA_0551</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could methylate the ribose at the nucleotide 34 wobble position in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine = 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43088"/>
            <dbReference type="Rhea" id="RHEA-COMP:10333"/>
            <dbReference type="Rhea" id="RHEA-COMP:10334"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74508"/>
            <dbReference type="ChEBI" id="CHEBI:74511"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(34) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43084"/>
            <dbReference type="Rhea" id="RHEA-COMP:10331"/>
            <dbReference type="Rhea" id="RHEA-COMP:10332"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.207" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0551"/>
    <dbReference type="EnsemblBacteria" id="ACL28850">
        <property type="protein sequence ID" value="ACL28850"/>
        <property type="gene ID" value="BLA_0551"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0551"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.581"/>
    <dbReference type="HOGENOM" id="CLU_110125_1_0_11"/>
    <dbReference type="OMA" id="AGLDYWH"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18094">
        <property type="entry name" value="SpoU-like_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01885">
        <property type="entry name" value="tRNA_methyltr_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016914">
        <property type="entry name" value="tRNA_cyt/urid_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42971">
        <property type="entry name" value="PTHR42971"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029256">
        <property type="entry name" value="SpoU_TrmH_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR029256-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="169" mass="18742" checksum="3337CE8EBFE079FD" modified="2009-03-03" version="1">MMTAREAAETPTTTPHLCYYSPRIPGNTGSAIRLCAVTGTILHLVEPLGFNLRDTKLRRAGLDYHDMAHVVLHPNFEDLVESMPNSRIIAFTAHATKLYTEVEYKPTDILLFGPEPGNIPDPMDIMAGPHVAEQVRLPMRPSLRSLNLTNCASIAIYEAWRQLGFDGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWL3</accession>
    <name>B8DWL3_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">3-IPM-DH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Beta-IPM dehydrogenase</fullName>
            <shortName evidence="3">IMDH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">leuB</name>
        <name evidence="5" type="ordered locus">BLA_0567</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218298.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0567"/>
    <dbReference type="EnsemblBacteria" id="ACL28864">
        <property type="protein sequence ID" value="ACL28864"/>
        <property type="gene ID" value="BLA_0567"/>
    </dbReference>
    <dbReference type="GeneID" id="66533695"/>
    <dbReference type="KEGG" id="bla:BLA_0567"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.598"/>
    <dbReference type="HOGENOM" id="CLU_031953_0_1_11"/>
    <dbReference type="OMA" id="EYDLGAR"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01035">
        <property type="entry name" value="LeuB_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023698">
        <property type="entry name" value="LeuB_actb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="4">
        <location>
            <begin position="9"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL28864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="346" mass="37467" checksum="5F3D6711C43DEA39" modified="2009-03-03" version="1">MTQNAKQYTIAVIPGDGIGKEVTPWAQQALEKATEGVATFEYEPFDLGAERYLRDGEILPDEDLERIKSTDAILLGAVGDPRIKAGILERGLLLKLRFALDQYVNLRPSKLYPGVESPLANPGEIDFVVVREGTEGLYCGAGGAIRRGTEHEVATEVSINTAYGVERVVRYAFELAMKRRKHVTLVHKKNVLVNAGDMWQNIVNKVAAEYPEVQHDYSHIDAATIYLVTDPSRFDVILTDNLFGDILTDEAGAVVGGVGYSASGCINASNEYPSMFEPIHGSAPDIAGQGIANPTAAILSAAMLLRHLGFDDAAAKIDAAVELDIAENGSRQRSTDEVGRDILARL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWS4</accession>
    <name>ATPA_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase subunit alpha</fullName>
            <ecNumber evidence="1">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F1 sector subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-ATPase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpA</name>
        <name type="ordered locus">BLA_0632</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219176.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DWS4"/>
    <dbReference type="SMR" id="B8DWS4"/>
    <dbReference type="STRING" id="442563.BLA_0632"/>
    <dbReference type="PRIDE" id="B8DWS4"/>
    <dbReference type="EnsemblBacteria" id="ACL28925">
        <property type="protein sequence ID" value="ACL28925"/>
        <property type="gene ID" value="BLA_0632"/>
    </dbReference>
    <dbReference type="GeneID" id="66533763"/>
    <dbReference type="KEGG" id="bla:BLA_0632"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.663"/>
    <dbReference type="HOGENOM" id="CLU_010091_2_1_11"/>
    <dbReference type="OMA" id="LQAPGVM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1_ATPase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0139">CF(1)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000166520" description="ATP synthase subunit alpha">
        <location>
            <begin position="1"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="520"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="173"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Required for activity" evidence="1">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="546" mass="58987" checksum="73BB353714D66C6A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWS5</accession>
    <name>ATPD_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F(1) sector subunit delta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-type ATPase subunit delta</fullName>
            <shortName evidence="1">F-ATPase subunit delta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpH</name>
        <name type="ordered locus">BLA_0633</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="1">This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase delta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269232.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DWS5"/>
    <dbReference type="SMR" id="B8DWS5"/>
    <dbReference type="STRING" id="442563.BLA_0633"/>
    <dbReference type="PRIDE" id="B8DWS5"/>
    <dbReference type="EnsemblBacteria" id="ACL28926">
        <property type="protein sequence ID" value="ACL28926"/>
        <property type="gene ID" value="BLA_0633"/>
    </dbReference>
    <dbReference type="GeneID" id="66533764"/>
    <dbReference type="KEGG" id="bla:BLA_0633"/>
    <dbReference type="HOGENOM" id="CLU_088880_0_0_11"/>
    <dbReference type="OMA" id="FRFGRIV"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020781">
        <property type="entry name" value="ATPase_OSCP/d_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="PTHR11910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00389">
        <property type="entry name" value="ATPASE_DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0139">CF(1)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000382061" description="ATP synthase subunit delta">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01416"/>
        </source>
    </evidence>
    <sequence length="277" mass="30996" checksum="8F013CF6420229F8" modified="2009-03-03" version="1">MQGEASRLADRESRDSFAAKLRESGNDAWEIGNELFTITYVFDHNPRIPRALTDPGRPTEDKVALLNNLLGKQALPLTMEILTDLVGRSWSRAGDIDNAIEDFAVDAMMYQADDEKKTLKVSVQLAQLQSALLNLPVVRSDLSDSQGPLNVRYELLHALIDGADFDRITVRLAEHCTRNPRNRRYLESVQWLINKFSRHMGESMVTVTTATPLSDEQSDKLARIYTKKTGRPVHIHSVVDPTVMGGMRIQVGDEVTDNTVVAQLENLKRKVKAGVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWU1</accession>
    <name>B8DWU1_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BLA_0649</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219149.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0649"/>
    <dbReference type="EnsemblBacteria" id="ACL28942">
        <property type="protein sequence ID" value="ACL28942"/>
        <property type="gene ID" value="BLA_0649"/>
    </dbReference>
    <dbReference type="GeneID" id="66533782"/>
    <dbReference type="KEGG" id="bla:BLA_0649"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.677"/>
    <dbReference type="HOGENOM" id="CLU_056175_0_0_11"/>
    <dbReference type="OMA" id="KPLHTIG"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACL28942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="367" mass="39349" checksum="8469B7766CF37A9C" modified="2009-03-03" version="1">MTKILIDDIIPIIVIMALGYVCGKLSYFDNDQRQGLNKLVLNIALPAALFISIVKATREMLAQDAVLTILGFIGIIVMFMLSYYLCRLMFHHSIQEAAVCALIAGSPTIGFLGFAVLDPIYGDTVSTNLVIAIISIVVNAVTIPIGMYLINLGQSKDRERLSKAAVTNSKGQVSIANPKDDIAVDPNKDAKTDKTAEVMISKSSNMGKKKNQNLEALINALKQPVCWAPLLAIVLVLIGVRVPSGFAPTFDLIAKANSGVAVLAAGLALSTVKFSLGWETIWNTFYRLILTPAAFLGVGLLLGMGSNVNKLSMLVMAVALPPAFSGIIISSRYNIYVKEGASTTAVSTVAFAVTCLLWIWLVPLCCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWU8</accession>
    <name>B8DWU8_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219139.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0656"/>
    <dbReference type="EnsemblBacteria" id="ACL28949">
        <property type="protein sequence ID" value="ACL28949"/>
        <property type="gene ID" value="BLA_0656"/>
    </dbReference>
    <dbReference type="GeneID" id="66533789"/>
    <dbReference type="KEGG" id="bla:BLA_0656"/>
    <dbReference type="HOGENOM" id="CLU_090966_0_0_11"/>
    <dbReference type="OMA" id="GWCFLPD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL28949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="282" mass="29772" checksum="4169E697DF4E03EF" modified="2009-03-03" version="1">MSETQHGNDARNAAADGELTADSTLTAQMAPDYRPVAPVAPFSRSVWLQIALYVVLVALACIPGSNAVSSVMFSLTGFVVGVMIMLFAFFTPLRDGIPGRVTGVILGLLGMIFASTPMLGEFVFGSMGSPSRPQLGSPGTLAVCAWFAGVGALLVVLVVVAFGRQMARLDRSHLIVQLSHMVMDGACTVLCSGWCFLPMLMQGFGESKAESANGELWVWIAGVVAIVVFAVGLGFMDRVWYRDSRPLEGAQAPWVGFALIPVMLTGGLVALATLVVQLTLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DSJ6</accession>
    <name>B8DSJ6_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0682</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219102.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0682"/>
    <dbReference type="EnsemblBacteria" id="ACL28975">
        <property type="protein sequence ID" value="ACL28975"/>
        <property type="gene ID" value="BLA_0682"/>
    </dbReference>
    <dbReference type="GeneID" id="66533815"/>
    <dbReference type="KEGG" id="bla:BLA_0682"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.711"/>
    <dbReference type="HOGENOM" id="CLU_059988_1_0_11"/>
    <dbReference type="OMA" id="PLEWHMI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="3">
        <location>
            <begin position="33"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="285" mass="31050" checksum="3ACBE2F904371CAA" modified="2009-03-03" version="1">MTAYMDHKDLANEVIDEVRAQQIADGVHRVMDRIAAAEERAGRPAGDVRLLAATKTRDVGEIMAAIDAGVPMIGENRPQEVVAKIDGLRYQCKQRGYVIGAYDFDLTVDADPTYAEPEDLKEAPFIPFHLIGQLQSNKISKILPTVNTVESVDSLELAEKIARRCMVRGRSMGVLLEVNESGEESKSGCAPDQALELAEQIAALGGVELQGLMTVGAHVRDERRIREGFAHLRGLRERIQSLGMPGTARCVELSMGMSGDLEYAIAEGATIVRVGSAIFGERDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT20</accession>
    <name>B8DT20_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glucan mod. protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29149">
        <property type="protein sequence ID" value="ACL29149"/>
        <property type="gene ID" value="BLA_0857"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0857"/>
    <dbReference type="HOGENOM" id="CLU_014385_0_0_11"/>
    <dbReference type="OMA" id="LRYQVPY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="298"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="689" mass="76890" checksum="7C0B46FD4C61AA6E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT72</accession>
    <name>B8DT72_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_0909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219254.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0909"/>
    <dbReference type="EnsemblBacteria" id="ACL29201">
        <property type="protein sequence ID" value="ACL29201"/>
        <property type="gene ID" value="BLA_0909"/>
    </dbReference>
    <dbReference type="GeneID" id="66533889"/>
    <dbReference type="KEGG" id="bla:BLA_0909"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.952"/>
    <dbReference type="HOGENOM" id="CLU_081578_2_2_11"/>
    <dbReference type="OMA" id="WINILML"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006938">
        <property type="entry name" value="DUF624"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04854">
        <property type="entry name" value="DUF624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="200" mass="22376" checksum="B3C86F8FB558266D" modified="2009-03-03" version="1">MKFLSPDSRFMQGWNDLTDAIWINMLMLVTSLPVVTAGAALCAGSTALRKSQRGQGTVTRNYFAAFRENLAKATLLWLIFGICGAAIAYSWIVLQITPLLIPKFALTIIWAIGFEWAFYLQARFENPLGQTLRNAYVFGVVYFPATLACVAIDVVFVGLLVAAWFYMPQGLFLLVVLGYGCMLALHVPILEYALRRYTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8DT82</accession>
    <name>B8DT82_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator of two-component system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BLA_0919</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217574.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0919"/>
    <dbReference type="EnsemblBacteria" id="ACL29211">
        <property type="protein sequence ID" value="ACL29211"/>
        <property type="gene ID" value="BLA_0919"/>
    </dbReference>
    <dbReference type="GeneID" id="66533467"/>
    <dbReference type="KEGG" id="bla:BLA_0919"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.962"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OMA" id="WTANDGD"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="141"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACL29211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="218" mass="23826" checksum="751C3C660C62E81F" modified="2009-03-03" version="1">MKVAIVDDDPIVCSSIGTILTTTGTAEVVWTAHDGAAAVVAYARQKPDVLLIDVQMPGTDGLEASERILVLTTFADPEYIRRAIELGTKGYLIKQDVASVIPAVQAVMAGQVVLGADVLRNLPMHDASGNVEEPKASPLPDDPRFAHLTDREHDIVELVAEELDNREIAAKLFLSEGTVRNRISGILAKTHISNRTKLAIEWLTSHDRHIHDHHIEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTD8</accession>
    <name>B8DTD8_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="1">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>9-ribosyl-trans-zeatin 5'-phosphate + H2O = D-ribose 5-phosphate + trans-zeatin</text>
            <dbReference type="Rhea" id="RHEA:48564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16522"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:87947"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate = D-ribose 5-phosphate + N(6)-dimethylallyladenine</text>
            <dbReference type="Rhea" id="RHEA:48560"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17660"/>
            <dbReference type="ChEBI" id="CHEBI:57526"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217644.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0977"/>
    <dbReference type="EnsemblBacteria" id="ACL29267">
        <property type="protein sequence ID" value="ACL29267"/>
        <property type="gene ID" value="BLA_0977"/>
    </dbReference>
    <dbReference type="GeneID" id="66533410"/>
    <dbReference type="KEGG" id="bla:BLA_0977"/>
    <dbReference type="HOGENOM" id="CLU_058336_0_4_11"/>
    <dbReference type="OMA" id="MFVKYSQ"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102682">
        <property type="term" value="F:N6-(Delta2-isopentenyl)-adenosine 5'-monophosphate phosphoribohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="267" mass="29145" checksum="B520C6AB1D2E2E77" modified="2009-03-03" version="1">MQSNNEENANGGQTMNHAEEPLGRTYSQGPVLLRGKMIPSESTSERFLRNDSDTDWLHRDPWRVLRIQAEFVDGFGSLAELGPAVSIFGSARVEPNTKDYKAAVAMGAKIAERDIAVITGGGPGIMEAANKGAAKAGGKSVGLGIELPHEQGLNKWINLGMTFRYFFVRKTMFMKYSSGVIVCPGGFGTLDETFEALTLVQTQKVAKMPIVLFDSAYWRGLFDWIDGPVRERGMISNIDPDLVTITDDIDEAVDVATSMVPRQTGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTG4</accession>
    <name>B8DTG4_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="6">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="6">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="6">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">msrA</name>
        <name evidence="8" type="ordered locus">BLA_1003</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 6">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="6"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217682.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1003"/>
    <dbReference type="EnsemblBacteria" id="ACL29293">
        <property type="protein sequence ID" value="ACL29293"/>
        <property type="gene ID" value="BLA_1003"/>
    </dbReference>
    <dbReference type="GeneID" id="66533384"/>
    <dbReference type="KEGG" id="bla:BLA_1003"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1046"/>
    <dbReference type="HOGENOM" id="CLU_031040_1_0_11"/>
    <dbReference type="OMA" id="GEFIPYI"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="PTHR10173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4 6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MsrB" evidence="7">
        <location>
            <begin position="181"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL29293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="330" mass="36843" checksum="FC25B4C8F4486C7B" modified="2009-03-03" version="1">MQRTEAAAPETHVAYMAGGCFWGLERAMQNVDGVLDTTVGYAQSITPDPTYRMVCSGTTHAVETVRIDYNPTRVSLRTLTLLFLSIIDPFSVDRQGNDVGSQYRSGLYPAGAHAAEQRAVYEQALDELAQRSGSTPAVEIEDLRNFTIAEPEHQDYLLANPTGYCHIPLSVIDHMRERQRHIERIWSLSPEQYAVTQQSATEPPFHNEYDRLFDPGIYVDRVSGEPLFFSTDKFDSGCGWPSFSTPIDQGSVRMVKDYSLPLHPRLEVRAVQSDSHLGHVFADGPRERGGMRYCMNSASLRFVPRDRMAEEGYGDLVGELDARLSASAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTK4</accession>
    <name>B8DTK4_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_1045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1045"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL29333">
        <property type="protein sequence ID" value="ACL29333"/>
        <property type="gene ID" value="BLA_1045"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1045"/>
    <dbReference type="HOGENOM" id="CLU_005856_0_0_11"/>
    <dbReference type="OMA" id="MRDDVDL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="531"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="585"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="607"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="629"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="707"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="737"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="763"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="808"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="133"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="1004" mass="109135" checksum="493676516DC96B79" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTT3</accession>
    <name>B8DTT3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lysyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">lysX</name>
        <name evidence="10" type="ordered locus">BLA_1124</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619938.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1124"/>
    <dbReference type="EnsemblBacteria" id="ACL29412">
        <property type="protein sequence ID" value="ACL29412"/>
        <property type="gene ID" value="BLA_1124"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1124"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1178"/>
    <dbReference type="HOGENOM" id="CLU_017891_0_0_11"/>
    <dbReference type="OMA" id="MEPAYGF"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="LPG_synthase_C" evidence="9">
        <location>
            <begin position="528"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="877"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACL29412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="922" mass="101409" checksum="A0DC96DB5C4B83C9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8DTT6</accession>
    <name>PUR5_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="1">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purM</name>
        <name type="ordered locus">BLA_1127</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIR synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218847.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DTT6"/>
    <dbReference type="SMR" id="B8DTT6"/>
    <dbReference type="STRING" id="442563.BLA_1127"/>
    <dbReference type="EnsemblBacteria" id="ACL29415">
        <property type="protein sequence ID" value="ACL29415"/>
        <property type="gene ID" value="BLA_1127"/>
    </dbReference>
    <dbReference type="GeneID" id="66532951"/>
    <dbReference type="KEGG" id="bla:BLA_1127"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1181"/>
    <dbReference type="HOGENOM" id="CLU_047116_0_0_11"/>
    <dbReference type="OMA" id="EPLFMTD"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000148268" description="Phosphoribosylformylglycinamidine cyclo-ligase">
        <location>
            <begin position="1"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00741"/>
        </source>
    </evidence>
    <sequence length="344" mass="36617" checksum="7D8CBF4B7771D930" modified="2009-03-03" version="1">MPQAYENAGVSVEAGYEVVKRIKSHVARTNRPGVVSGIGGFGGLFDLASLGYNEPVLISGTDGVGTKLVIAKLMDKHDTIGIDCVAMCVNDVVAQGAQPLFFLDYIACGKNDPAVLEQVVSGVADGCVQAGAALIGGETAEMPGMYDEDEYDLAGFTVGCVERSKIVDGSTIEAGDVLIGLPSTGVHSNGFSLVRKALFEQAGYTVHTRLPELDDRELGDVLLTPTKIYVKALMPLFEANLVRGVAHITGGGFIENVPRMLPEGLAASIELGSWPVPPIFDVIEKAGDVDHMEMYNIFNMGLGMVVAIRPDRVDEAMNLLEHAGEKAYRVGHVIEQVNERVDLA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DU64</accession>
    <name>SYY_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="1">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tyrS</name>
        <name type="ordered locus">BLA_1255</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218069.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DU64"/>
    <dbReference type="SMR" id="B8DU64"/>
    <dbReference type="STRING" id="442563.BLA_1255"/>
    <dbReference type="EnsemblBacteria" id="ACL29543">
        <property type="protein sequence ID" value="ACL29543"/>
        <property type="gene ID" value="BLA_1255"/>
    </dbReference>
    <dbReference type="GeneID" id="66533077"/>
    <dbReference type="KEGG" id="bla:BLA_1255"/>
    <dbReference type="HOGENOM" id="CLU_024003_0_3_11"/>
    <dbReference type="OMA" id="YMMAKDS"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="PTHR11766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_1000189258" description="Tyrosine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="S4 RNA-binding" evidence="1">
        <location>
            <begin position="373"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="241"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02006"/>
        </source>
    </evidence>
    <sequence length="440" mass="48651" checksum="D3D0D0A6A2812761" modified="2009-03-03" version="1">MAHVIDFKEAGFDSVLDELEWRGLISQSTDRDRLAHTLNGEPVHYYCGFDPTAPSLHIGNLVQLIIMRHLQEAGHHPIALVGGATGLIGDPRQSGERILNPKDIVEQWCERLRIQIGGILEQEGSNPVTFVSNYDWTATMNVLDFLRDIGKNFRVGTMISKDIVARRLNSEEGISFTEFSYQVLQGNDYLYLYDHYDCVLELGGSDQWGNLTSGLDLIHKVRGVNVNVMASPIITDANGKKFGKSEGNAVWLDPNMLSVYKFYQFWLNRPDVEMASLLKAFTFLPKAEIERLVEATDTNPGAREAQRVLAWEVTSLVHGDEPTRKAIDASASLFGRGGDLADIDLETLESVLDGLKVENEAGEKVFAQALPGDRIAQAGVSAGLFKSISEARKTIKSGGVYVNNVRVEDEEQLLGDGDFLKGRFVVLRRGKKALGVVARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUB5</accession>
    <name>B8DUB5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uracil-DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BLA_1307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004217998.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1307"/>
    <dbReference type="EnsemblBacteria" id="ACL29594">
        <property type="protein sequence ID" value="ACL29594"/>
        <property type="gene ID" value="BLA_1307"/>
    </dbReference>
    <dbReference type="GeneID" id="66533133"/>
    <dbReference type="KEGG" id="bla:BLA_1307"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.1369"/>
    <dbReference type="HOGENOM" id="CLU_075800_0_0_11"/>
    <dbReference type="OMA" id="GFCYPGK"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="1">
        <location>
            <begin position="28"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACL29594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="196" mass="22558" checksum="DC646400D48D8C6E" modified="2009-03-03" version="1">MDTIESITKQIMDDPRDAEFTKRGEKPVFSAPSTALITIVGQSPSLDAQTRGLCWNDRSGDTLRKWLDVDKETFYDSGKFALVPMDFYYLGDVPGDKGMEEPREWVAPTYHPEIMKLLPDVKLTILAGSNAVKYYLNQWSKARLEDTVKHFQEYLPKYFPIVHPSGRTDIWRTEHPWFDETVVPALREHVHAILGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DUT3</accession>
    <name>B8DUT3_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetracycline resistance protein TetW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tetW</name>
        <name evidence="3" type="ordered locus">BLA_1480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL29762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_1480"/>
    <dbReference type="EnsemblBacteria" id="ACL29762">
        <property type="protein sequence ID" value="ACL29762"/>
        <property type="gene ID" value="BLA_1480"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_1480"/>
    <dbReference type="HOGENOM" id="CLU_002794_13_0_11"/>
    <dbReference type="OMA" id="ESYVNNE"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="2">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL29762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="412" mass="45832" checksum="9F642CE9830F463B" modified="2009-03-03" version="1">MKIINIGILAHVDAGKTTLTESLLYASGAISEPGSVEKGTTRTDTMLLERQRGITIQAAVTSFQWHRCKVNIVDTPGHMDFLAEVYRSLAVLDGAILVISAKDGVQAQTRILFHALRKMNIPTVIFINKIDQAGVDLQSVVQSVRDKLSADIIIKQTVSLSPEIVLEENTDIEAWDAVIENNDKLLEKYIAGEPISREKLVREEQRRVQDASLFPVYYGSAKKGLGIQPLMDAVTGLFQPIGEQGSAALCGSVFKVEYTDCGQRRVYLRLYSGTLRLRDTVALAGREKLKITEMRIPSKGEIVRTDTAYPGEIVILPSDSVRLNDVLGDPTRLPRKRWREDPLPMLRTSIAPKTAAQRERLLDALTQLADTDPLLRCEVDSITHEIILSFLGRVQLEVVSALLSEKYSLKQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DV12</accession>
    <name>B8DV12_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BLA_0007</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219028.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0007"/>
    <dbReference type="EnsemblBacteria" id="ACL28313">
        <property type="protein sequence ID" value="ACL28313"/>
        <property type="gene ID" value="BLA_0007"/>
    </dbReference>
    <dbReference type="GeneID" id="66532380"/>
    <dbReference type="KEGG" id="bla:BLA_0007"/>
    <dbReference type="HOGENOM" id="CLU_046697_2_0_11"/>
    <dbReference type="OMA" id="TRVDPWS"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021949">
        <property type="entry name" value="DUF3566_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12089">
        <property type="entry name" value="DUF3566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3566" evidence="3">
        <location>
            <begin position="61"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACL28313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="178" mass="19101" checksum="45F69A3B7F60FC6A" modified="2009-03-03" version="1">MSNTNPLEPGQQPRAAASSAADNAPRVARSASNTPLIADRDRPEENRPVRPIRNRKKPHARRMNLSLTRVSAWSVAKVSFMLSLAGAIIQIIAVLFLWLLLKAVGVFDQVTQIFSSAGLDSGSINLSNILSLPTVLSAVTIFSIVEMVIITILCTIFALLYNVVSALVGGVHVTLGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2020-02-26" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVA2</accession>
    <name>B8DVA2_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BLA_0100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACL28403">
        <property type="protein sequence ID" value="ACL28403"/>
        <property type="gene ID" value="BLA_0100"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0100"/>
    <dbReference type="HOGENOM" id="CLU_3402291_0_0_11"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACL28403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="30" mass="3378" checksum="1E9A98FD17D2A353" modified="2009-03-03" version="1">MRALPVATPRSADYHMPNMHDHAADWSDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVB0</accession>
    <name>B8DVB0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, LysR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218406.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0108"/>
    <dbReference type="EnsemblBacteria" id="ACL28411">
        <property type="protein sequence ID" value="ACL28411"/>
        <property type="gene ID" value="BLA_0108"/>
    </dbReference>
    <dbReference type="GeneID" id="66532483"/>
    <dbReference type="KEGG" id="bla:BLA_0108"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.112"/>
    <dbReference type="HOGENOM" id="CLU_039613_6_2_11"/>
    <dbReference type="OMA" id="KQGRNIM"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="289" mass="32713" checksum="599213DD0F11F978" modified="2009-03-03" version="1">MEIRELRAFLEVAREENMTRAAGNLHMSQPSLSKLIKSLEHELGAKLFVRRSFGLTLTKEGRVLRERARDLVGMANRIEDEFASLGNITGGTLYFGLAESYQIQYLARQIKILREQAPDLRYHVESGVSAQVLEHLDQGSLDFAVLAQDPDLTKYEALTFPGVDRWGIIVPADHRLASRSYVELDDLVGEPLFCSQQGWKHEIARWAGSRMPDLRLEATFGLAYNAAVFAREGLGVLLTFDRIVDTSADSGIVFRPLKPALETKLHLVWRRNRPLSPIAERFLDQLRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVC6</accession>
    <name>B8DVC6_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BLA_0124</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004218422.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0124"/>
    <dbReference type="EnsemblBacteria" id="ACL28427">
        <property type="protein sequence ID" value="ACL28427"/>
        <property type="gene ID" value="BLA_0124"/>
    </dbReference>
    <dbReference type="GeneID" id="66532499"/>
    <dbReference type="KEGG" id="bla:BLA_0124"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.130"/>
    <dbReference type="HOGENOM" id="CLU_031365_1_0_11"/>
    <dbReference type="OMA" id="KMQALVL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL28427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="327" mass="35259" checksum="7895CA1739A6D7FC" modified="2009-03-03" version="1">MDFMTILSNILGELFAPTTAAYALAAIGLNIHFGMSGLMNMGQAGFMLLGAYGFAITQMNGCDLFTSVLTALVLAAIYGILLGIPTLKLGPDYLAMVTLAAAEIIRIVGRSTSLTWLTGGSAGIAPQNFTEKFENASPLPNGSTKFLLWTYNNNIANSWWLRIVAWVLVAIALLLCWRWFHSPWGRVLKGIREDENAIRSLGKSVTKYKMQALILGGLFGAIAGIVFILPRSLNPDSLGRTVTFYTWTILLLGGAATIMGPVLGSCVLWVLLTAVKETMRVTIPTTVVSSNQIEALGWVIVGVALMLLVIFRPQGILGNKKELAFNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DVS5</accession>
    <name>B8DVS5_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonuclease PH</fullName>
            <shortName evidence="4">RNase PH</shortName>
            <ecNumber evidence="4">2.7.7.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rph</name>
        <name evidence="7" type="ordered locus">BLA_0274</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>phosphate + tRNA(n+1) = a ribonucleoside 5'-diphosphate + tRNA(n)</text>
            <dbReference type="Rhea" id="RHEA:10628"/>
            <dbReference type="Rhea" id="RHEA-COMP:17343"/>
            <dbReference type="Rhea" id="RHEA-COMP:17344"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:173114"/>
            <dbReference type="EC" id="2.7.7.56"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homohexameric ring arranged as a trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.56" evidence="4"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268397.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0274"/>
    <dbReference type="EnsemblBacteria" id="ACL28576">
        <property type="protein sequence ID" value="ACL28576"/>
        <property type="gene ID" value="BLA_0274"/>
    </dbReference>
    <dbReference type="GeneID" id="66532649"/>
    <dbReference type="KEGG" id="bla:BLA_0274"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.291"/>
    <dbReference type="HOGENOM" id="CLU_050858_0_0_11"/>
    <dbReference type="OMA" id="KGKGQGW"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009022">
        <property type="term" value="F:tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11362">
        <property type="entry name" value="RNase_PH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00564">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002381">
        <property type="entry name" value="RNase_PH_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018336">
        <property type="entry name" value="RNase_PH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01966">
        <property type="entry name" value="RNasePH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01277">
        <property type="entry name" value="RIBONUCLEASE_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="RNase_PH" evidence="5">
        <location>
            <begin position="13"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="6">
        <location>
            <begin position="163"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate (substrate) binding" evidence="4">
        <location>
            <begin position="127"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL28576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="246" mass="26736" checksum="E010C2ABEE613167" modified="2009-03-03" version="1">MTVTRADGRAYDELRPVRITRAFTDVPEGSVLIECGNTRVMCTATFTDTVPRWRKDSGLGWVTAEYSMLPRATAQRTDRESVRGKVGGRTHEISRLIGRCLRGVIDMKALGENTIQMDCDVLQADGGTRTASITGAHVALVDALNWAKQNGKIKSVKNVLLDSVSAVSVGVIDGEPMLDLPYVEDSRAMTDMNVAMTGSGKFVEIQGTAEHRPFSRNELGVLLDLATKGNRELQAAQQAALDADLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWB5</accession>
    <name>B8DWB5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BLA_0467</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AD011</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0467"/>
    <dbReference type="EnsemblBacteria" id="ACL28766">
        <property type="protein sequence ID" value="ACL28766"/>
        <property type="gene ID" value="BLA_0467"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0467"/>
    <dbReference type="HOGENOM" id="CLU_031275_6_2_11"/>
    <dbReference type="OMA" id="GAYVKRY"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="453"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="453"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACL28766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="519" mass="57097" checksum="8528B53EA167295F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWC0</accession>
    <name>TILS_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Ile)-lysidine synthase</fullName>
            <ecNumber evidence="1">6.3.4.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA(Ile)-2-lysyl-cytidine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA(Ile)-lysidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tilS</name>
        <name type="ordered locus">BLA_0472</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA(Ile)-lysidine synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012619734.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DWC0"/>
    <dbReference type="SMR" id="B8DWC0"/>
    <dbReference type="STRING" id="442563.BLA_0472"/>
    <dbReference type="EnsemblBacteria" id="ACL28771">
        <property type="protein sequence ID" value="ACL28771"/>
        <property type="gene ID" value="BLA_0472"/>
    </dbReference>
    <dbReference type="GeneID" id="66532857"/>
    <dbReference type="KEGG" id="bla:BLA_0472"/>
    <dbReference type="HOGENOM" id="CLU_018869_1_0_11"/>
    <dbReference type="OMA" id="PWQDPHN"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="PP-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015262">
        <property type="entry name" value="tRNA_Ile_lys_synt_subst-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="PTHR43033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09179">
        <property type="entry name" value="TilS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_1000164316" description="tRNA(Ile)-lysidine synthase">
        <location>
            <begin position="1"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="50"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01161"/>
        </source>
    </evidence>
    <sequence length="382" mass="41836" checksum="180A539818BC0DD9" modified="2009-03-03" version="1">MAYSAAMKAAIGEMRDVLKAHGLGQQSKEFSAHGEHKPHDDAPFVFVACSGGRDSLALAACAQVVCAAWGIRCGAIIVDHHLQDASHKVAQQTAQTCRDLGLEPVLIVDVQVKERGQGIEAAAREARYAALVGTARRWHATAVLLAHTKDDQAESILIDLIRAAGTDAFAGMPQTQLFDDVLVLRPLLGITRAQTTRICEDEGLEYWDDPTNGDAVPLETALPASYPLRSRVRHDLMPYLSAFAGCDMVDRLARTARIARRDVEALNQEAERALAQTVEFEGNMRDLQADRLADDKLGANIDARALERWPEAIRYRVIARTLAACGLAYASRHVAAVDKLVSQWHGQGKVALPSKYSAKRKAHVIRICEDITHANRRCAKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWC5</accession>
    <name>B8DWC5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioesterase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tesB</name>
        <name evidence="3" type="ordered locus">BLA_0477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004268804.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0477"/>
    <dbReference type="EnsemblBacteria" id="ACL28776">
        <property type="protein sequence ID" value="ACL28776"/>
        <property type="gene ID" value="BLA_0477"/>
    </dbReference>
    <dbReference type="GeneID" id="66532862"/>
    <dbReference type="KEGG" id="bla:BLA_0477"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.506"/>
    <dbReference type="HOGENOM" id="CLU_032690_0_1_11"/>
    <dbReference type="OMA" id="SQVWFRT"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="PTHR11066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="301" mass="33660" checksum="B52E9A9E682A62BC" modified="2009-03-03" version="1">MASDTKTPLQRIVDVLKLGEPSQYRDHTYINGESMYFPTGRVYGGQVISQSLIAASKTVPEDRLPHSIHGYFIAPGDIHQDLLFDVENLRDGHSFSARRVNVTQSQGSILTAIASFQTKDQPGVEYFDPMPADVPDPESLPSSVDLMKPYADQSDYAKYYATTSPFDIRYISSPIVLGPDEESHRLDTGKQMLWMRAMGEIEVSQTFHRALLALGCDQVMLEPILRRAGLTLLTPGISFASIDHSMWWYRDIDVTKWHLYVQDTPTAAHGRGLSSAKVYSQEGDLVACMVQEAMIRVPQTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWF0</accession>
    <name>B8DWF0_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter, ATP-binding transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BLA_0502</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0502"/>
    <dbReference type="EnsemblBacteria" id="ACL28801">
        <property type="protein sequence ID" value="ACL28801"/>
        <property type="gene ID" value="BLA_0502"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0502"/>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_11"/>
    <dbReference type="OMA" id="KVFSHEP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="52"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="446"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="479"/>
            <end position="486"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL28801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="685" mass="75278" checksum="C9E0A0E8C4D77718" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWH9</accession>
    <name>GLMM_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoglucosamine mutase</fullName>
            <ecNumber evidence="1">5.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glmM</name>
        <name type="ordered locus">BLA_0531</name>
    </gene>
    <organism>
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23424"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="5.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Activated by phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.10" evidence="1"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004269221.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DWH9"/>
    <dbReference type="SMR" id="B8DWH9"/>
    <dbReference type="STRING" id="442563.BLA_0531"/>
    <dbReference type="EnsemblBacteria" id="ACL28830">
        <property type="protein sequence ID" value="ACL28830"/>
        <property type="gene ID" value="BLA_0531"/>
    </dbReference>
    <dbReference type="GeneID" id="66533661"/>
    <dbReference type="KEGG" id="bla:BLA_0531"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.559"/>
    <dbReference type="HOGENOM" id="CLU_016950_7_0_11"/>
    <dbReference type="OMA" id="PHNPEPL"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05802">
        <property type="entry name" value="GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01554_B">
        <property type="entry name" value="GlmM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006352">
        <property type="entry name" value="GlmM_bact"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01455">
        <property type="entry name" value="glmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000185352" description="Phosphoglucosamine mutase">
        <location>
            <begin position="1"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01554"/>
        </source>
    </evidence>
    <sequence length="454" mass="47765" checksum="927CEEA7CA6BE14C" modified="2009-03-03" version="1">MPRMFGTDGVRGLANRDLTAQLALDLGDAAVRVLGDDGGRETNRHRALIGRDTRVSGDFLSHALAAGMSAGGFDVIDAGIIPTPGVAFLTSVLNVEMGAVISASHNPMPDNGIKFFARGGFKLPDTKEDEIEAVLGQDWERPTGAGVGRVSHDTTTATNLYIDHLVSAIAPEGNEQPLKGLKVVADCANGATSVVAPEALRRAGADVIVINASPDGYNINKNAGSTHPESMQAMVRASGADLGVAFDGDADRCLAADAEGNMVNGDQIMGILARAKKREGKLNHDTLVVTVMSNLGLKLALKEMGIDTVQTNVGDRYVLEEMLRGDYSLGGEQSGHVINREFATTGDGTLTALTLCNEVVKSGKSLKELAADFPQLPQQLINVPNVDKMAAKTNKAVLEAVAREEELLGDTGRVLLRPSGTEPLVRVMAEAATQEQADEVTARLAQIVADELAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWL5</accession>
    <name>B8DWL5_BIFA0</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase component of ABC transporters with duplicated ATPase domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BLA_0569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AD011</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0569"/>
    <dbReference type="EnsemblBacteria" id="ACL28866">
        <property type="protein sequence ID" value="ACL28866"/>
        <property type="gene ID" value="BLA_0569"/>
    </dbReference>
    <dbReference type="KEGG" id="bla:BLA_0569"/>
    <dbReference type="HOGENOM" id="CLU_038931_2_0_11"/>
    <dbReference type="OMA" id="DMFPDAP"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="DUF2183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2183" evidence="2">
        <location>
            <begin position="342"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACL28866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="487" mass="53351" checksum="8CA495BE12E13365" modified="2009-03-03" version="1">MLEAALAQVKREQAERARLAADGDGSTVATQGRTVRSGEGPTDADFDDTQHAGSAETRVITGIANGQAETETPERQWRAPAVALRTTSAATSTDDMPTVAVPLGSLSAAKAPAGRTRLRRNPKLVSSIKRVLRKAITWTFGLWIRFSTAIAKQLHWFPMVKPYVGYGTEEYSRLVCRTILAPADGQPNKPMRGIHAMLEVPAPGQCVQIDIDGVPLRTVQVGTMEVYNPVDSARSVTMDYSVSDSAGYLDLLAEHRLEPGVHMVSCKVTRRPAVEAELFTIPSTAKVGVISDVDDTCMVTQVPTLWKAVYNMLFLSPHKRASVPGMAVMYNKIASMFPGAPFFYLSTSPWNVENSIRNFLKDYGFPDGPLLLRDLDPRPKTFVPSGVQHKLEYAEQLMEDFPDMKFILIGDDGQKDPTTYAEIARRYPGRVLAIGIRQLSPKESGGFGTMSGFSTTQPVPVTDVPVFTGTTGSNIMKTMLPYLRQFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWS9</accession>
    <name>B8DWS9_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homoserine O-acetyltransferase</fullName>
            <shortName evidence="4">HAT</shortName>
            <ecNumber evidence="4">2.3.1.31</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Homoserine transacetylase</fullName>
            <shortName evidence="4">HTA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">metA</name>
        <name evidence="4" type="synonym">metAA</name>
        <name evidence="7" type="ordered locus">BLA_0637</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13701"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="EC" id="2.3.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-acetyl-L-homoserine from L-homoserine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MetA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.31" evidence="4"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219169.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0637"/>
    <dbReference type="EnsemblBacteria" id="ACL28930">
        <property type="protein sequence ID" value="ACL28930"/>
        <property type="gene ID" value="BLA_0637"/>
    </dbReference>
    <dbReference type="GeneID" id="66533768"/>
    <dbReference type="KEGG" id="bla:BLA_0637"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.668"/>
    <dbReference type="HOGENOM" id="CLU_057851_0_1_11"/>
    <dbReference type="OMA" id="WLWFCYQ"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008899">
        <property type="term" value="F:homoserine O-succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019281">
        <property type="term" value="P:L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03131">
        <property type="entry name" value="GATase1_HTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00295">
        <property type="entry name" value="MetA_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005697">
        <property type="entry name" value="HST_MetA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033752">
        <property type="entry name" value="MetA_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20919">
        <property type="entry name" value="PTHR20919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04204">
        <property type="entry name" value="HTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000450">
        <property type="entry name" value="H_ser_succinyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01001">
        <property type="entry name" value="metA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="4 5">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for acyl-CoA specificity" evidence="4">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000450-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACL28930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="342" mass="39500" checksum="6E2B5014D632A012" modified="2009-03-03" version="1">MPIKIPGGLPARAILDSERIFALEKPEAERQRVRPLKMVILNLMPKKIETETQLLRLISKSPLQVEIDFMKTSTHESKHVSADHLVKFYEPLEAYEGNCYDGLIVTGAPVEHLRFEDVDYWDEFKRVLDWSSTHVFSTMYMCWGAMAALYQRYGVHKMDLDEKLFGVFPQFLQDEYCFLTNGFDEIALQPHSRLAGVNEADIAANPELQVLTWGPQAGPGLIATRDFSEVFALGHWEYGKYTLAEEYRRDMAKGMSNVPFPRNYFPNDDPALAPLFSWRAHANLLWRNWLNWVYQTTPYDLSEVPQLRAERRLGTDRSIRHAPCSPRDDQFLPFDTSGYGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DWV0</accession>
    <name>B8DWV0_BIFA0</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Endonuclease III</fullName>
            <ecNumber evidence="9">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">nth</name>
        <name evidence="11" type="ordered locus">BLA_0658</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Bifidobacterium animalis subsp. lactis (strain AD011)</name>
        <dbReference type="NCBI Taxonomy" id="442563"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Bifidobacteriales</taxon>
            <taxon>Bifidobacteriaceae</taxon>
            <taxon>Bifidobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="J. Bacteriol." volume="191" first="678" last="679">
            <title>Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011.</title>
            <authorList>
                <person name="Kim J.F."/>
                <person name="Jeong H."/>
                <person name="Yu D.S."/>
                <person name="Choi S.-H."/>
                <person name="Hur C.-G."/>
                <person name="Park M.-S."/>
                <person name="Yoon S.H."/>
                <person name="Kim D.-W."/>
                <person name="Ji G.E."/>
                <person name="Park H.-S."/>
                <person name="Oh T.K."/>
            </authorList>
            <dbReference type="PubMed" id="19011029"/>
            <dbReference type="DOI" id="10.1128/JB.01515-08"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AD011</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="9"/>
    <dbReference type="EMBL" id="CP001213">
        <property type="protein sequence ID" value="ACL28951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004219134.1">
        <property type="nucleotide sequence ID" value="NC_011835.1"/>
    </dbReference>
    <dbReference type="STRING" id="442563.BLA_0658"/>
    <dbReference type="EnsemblBacteria" id="ACL28951">
        <property type="protein sequence ID" value="ACL28951"/>
        <property type="gene ID" value="BLA_0658"/>
    </dbReference>
    <dbReference type="GeneID" id="66533791"/>
    <dbReference type="KEGG" id="bla:BLA_0658"/>
    <dbReference type="PATRIC" id="fig|442563.4.peg.686"/>
    <dbReference type="HOGENOM" id="CLU_012862_3_3_11"/>
    <dbReference type="OMA" id="QIIWYGR"/>
    <dbReference type="Proteomes" id="UP000002456">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01083">
        <property type="entry name" value="nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="10">
        <location>
            <begin position="45"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACL28951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002456"/>
        </source>
    </evidence>
    <sequence length="247" mass="27883" checksum="65B58D33089A2BC0" modified="2009-03-03" version="1">MAGESRKARITRMHRQYETLCEFIPTVKCQLDFHTPFELLVATILSAQTTDKRVNSITPELFGTYPTAAALADARLEDVESIIRPLGFYHVKAEHIIAVARQIVERFGGQIPQTMEELTSLPGVGRKTANVVLGNAFRVPGFPVDTHVIRVTGRLHWRDDWMKTSTTPERIEQEITGCFPESEWTDLSHRLIIFGRNICTSRSPECENCPLLPTCPSAGEFLEIAAERKARATRRAPRKPRSRKTAK</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>